CN1184433A - Electrotransport device having reusable controller - Google Patents
Electrotransport device having reusable controller Download PDFInfo
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- CN1184433A CN1184433A CN96193927A CN96193927A CN1184433A CN 1184433 A CN1184433 A CN 1184433A CN 96193927 A CN96193927 A CN 96193927A CN 96193927 A CN96193927 A CN 96193927A CN 1184433 A CN1184433 A CN 1184433A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0432—Anode and cathode
- A61N1/044—Shape of the electrode
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0448—Drug reservoir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
- A61N1/303—Constructional details
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0432—Anode and cathode
- A61N1/0436—Material of the electrode
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
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- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Electrotherapy Devices (AREA)
- Processing Of Solid Wastes (AREA)
- Pinball Game Machines (AREA)
- Crushing And Pulverization Processes (AREA)
- Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
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Abstract
An electrotransport system (10) includes a reusable controller (12) having a power source (20) and a separable disposable drug-containing unit (30) which contain both a donor electrode (32) and a counter electrode (34). A coupling means (26, 28, 36, 38) physically and electrically connects together the controller (12) and the drug unit such that the controller (12) provides electrical current to the drug unit (30) for electrotransport delivery of the drug to a body surface (e.g., the skin) of a patient. The coupling means (26, 28, 36, 38) ensures correct polarity connection of the donor and counter electrodes (32, 34) to the outputs of the controller (12).
Description
The present invention relates to the system that electric drive (electrotransport) transmits medicine, it comprises parts and a controller that re-uses that has the control circuit that is powered of a powder charge.The parts of this powder charge and controller are detachably coupled together them by a bonder, so just set up being electrically connected between these parts and the controller.
" electric drive " used herein this term typically refer to transmit a kind of reagent (such as: medicine), make it pass a kind of film, such as skin, mucosa or fingernail.This transmission is in the help of electromotive force or induces down and finish.For example, a kind of useful treatment reagent blood circulation that can under the inducing that electric drive transmits, enter human body by skin.Electromigration (being also referred to as ionophoresis (iontophoresis)) is an electric drive process of widely using, it and charged ion mobile relevant under the inducing of electricity.The electric drive electro-osmosis of another kind of type with liquid mobile relevant under effect of electric field, comprises the reagent of needs transmission in the liquid.Electric drive-electric the holeization (eletroporation) of another kind of type is with under effect of electric field, and the formation in the temporary transient hole that exists is relevant in the biomembrane.The agent examination can enter in the hole in mode (promptly under the effect of electromotive force) initiatively, or enters in the hole in passive mode (promptly not having the help of electricity).Yet, in the process of above any electric drive, have at least two kinds of processes to take place simultaneously to a certain extent.Corresponding, " electric drive " used herein this term should be invested the most possible explanation, be that it comprises at least a reagent (this reagent may be charged, may be not charged yet, or the both has) the transmission that under the inducing of electricity or by electricity, improves, and no matter this reagent is the transmission of carrying out with any or several mechanism actually.
Electronic driver uses at least two electrodes, and the other parts of they and skin, fingernail, mucosa or body surface electrically contact.One of them electrode is commonly referred to " alms giver " or " initiatively " electrode, is that medicament is sent into intravital electrode.Another electrode is commonly referred to negation or " returning " electrode, is used for making circuit to pass through to form the loop behind the health.For example, if the reagent that transmits is positively charged, i.e. cation, then anode is initiatively or donor electrode, at this moment negative electrode is used for making circuit to become the loop.If reagent is electronegative conversely speaking,, i.e. anion, then negative electrode is a donor electrode.In addition, if contain cation and anion simultaneously in the medicament that transmits, or uncharged or neutral reagent, then anode and negative electrode all are donor electrode.
In addition, the electric drive transfer system needs a container or a reagent source of waiting to transmit reagent usually at least, and reagent is liquid solution or suspension normally.This reagent container comprises sack or cavity, porous sponge or mat and hydrophilic polymers or gel-in-matrix.This alms giver's container is connected with body surface with negative electrode (or negative pole), and is positioned between the two, is used to provide the fixed or renewable reagent source or the medicine source of one or more medicaments or reagent.Electronic driver has a power supply, as being made up of one or more batteries.Usually, a utmost point of power supply links to each other with donor electrode, and the other end links to each other with antielectrode.In addition, some electronic driver has an electric controller, controls the electric current of the electrode of flowing through by it, thereby the transfer rate of reagent is regulated.In addition, passive mobile controlling diaphragm, the binding agent that assurance device contacts with body surface, insulation assembly, and fluid-tight liner other available parts that are electronic driver.
The reagent delivery of all electric drive all uses circuit that power supply (as battery) and electrode are linked up.In some simply install, as disclosed in the United States Patent (USP) 4,474,570 of inventions such as Ariura, should " circuit " be one section conductor wire just, with it battery and electrode are connect.The device that has has used multiple electronic component that the electric current that power supply provides is controlled, and adjusts its amplitude, polarity, conduction time, and waveform etc.Can be referring to the United States Patent (USP) 5,047,007 of inventions such as McNichols.
Now, the business-like percutaneous medicament electric drive transporter (Phoresor that sells by the lomed company of salt lake city, the Utah State for example, the Dupel Iontophoresis system that sells by the Empi company in Sao Paulo, the Minnesota State, the Webster Sweat Inducer that the Wescor company of Lip river, Utah State root sells, 3600 types) use the electrode of desktop supply unit and a pair of and contact skin usually.Donor electrode is equipped with drug solution, and the electrolysed saline solution obtained of bio-compatibility is housed in the antielectrode.Use the lead or the cable of long (such as 1-2 rice) that " satellite " electrode and electric supply installation are linked up.The example of the desktop supply unit of use " satellite " electrode assemblie is open in following patent: the United States Patent (USP) 4 of invention such as Jacobsen, 141,359 (seeing Fig. 3 and 4), the United States Patent (USP) 5 of Laprade invention, the United States Patent (USP) 5 of invention such as 006,108 (see figure 9) and Maurer, 254,081 (seeing Fig. 1 and 2).Supply unit in these devices has the control device that is used for adjusting by the magnitude of current of electrode.Existing business-like electronic driver only allows to be operated on it by trained medical skill personnel.When with " satellite " when electrode is connected to electric supply installation, it is extremely important that to analyse any be to guarantee that electrode and correct polarity joins, the satellite donor electrode that the cation medicament promptly is housed must link to each other with the positive output end of controller, and the satellite donor electrode that the anion medicament is housed must link to each other with the negative output terminal of controller.Connect in order to help the medical skill personnel to carry out correct polarity, adopted following two kinds of methods.First method is that the outfan and the corresponding satellite electrode of controller are made labelling with color.Second method (having obtained employing in the CF indicator of being sold by Scandipharm company) is, controller has the metal pellet electrode of (as, rustless steel), and these electrodes are installed in a side of controller housing.Two electrode slices have different geometry (such as the side of being, is round).It is corresponding with the shape of electrode slice respectively that alms giver's gel of powder charge and the reverse gel that electrolyte is housed have different shapes, can guarantee that like this alms giver and reverse gel are connected with correct (being correct polarity) electrode.
Occurred being worn over small-sized self-contained (self-contained) electric drive transporter on the skin recently, when this device is worn over below the clothes, has seemed not conspicuous, and can wear for a long time.In the electric drive drug delivery devices of this microminiaturization, electronic component preferably also is microminiaturized, can be integrated circuit (being little process chip), or small-sized printed circuit.The amplitude of the circuit control source current of forming by electronic components such as battery, resistance, pulse generator, electric capacity, polarity, references such as conduction time and waveform.This small-sized self-contained electric drive transporter is disclosed in the following patent: the United States Patent (USP) 5,224,927 of Tapper invention for example, the United States Patent (USP) 5,246,418 of inventions such as the United States Patent (USP) 5,224,928 of invention such as Sibalis and Haynes.
Recently, the someone advises adopting the electronic driver that has reusable controller, and this controller is applicable to that the assembly with a plurality of powder charges is used.Only need take off on the assembly slave controller with powder charge simply after intact when medicinal, connect a new assembly that installs medicine and controller just passable then.When adopting this mode, relative more expensive hardware element in the device, (as battery, light emitting diode, circuit hardware etc.) are included in the reusable controller, and relatively cheap alms giver's container and anti-container can be included in the powder charge assembly of disposal type, can reduce the cost of whole electric drive drug delivery devices like this.At Sage, the United States Patent (USP) 5,320,597 of invention such as Jr; The United States Patent (USP) 5,358,483 of Sibalis invention; The United States Patent (USP) 5,135,479 (Figure 12) of invention such as Sibalis; In the UK Patent Application 2 239 803 of Devane etc., the example of the electronic driver that comprises a reusable controller that removably is connected with the powder charge assembly is disclosed.
Have reusable controller, the electronic driver that can use with a plurality of powder charge assemblies, particularly suitable carries out medication management to (for example those the need the long term medical nursing) patient outside the environment of clinic.Unfortunately, guarantee in the existing scheme that the design that the container of the powder charge of electronic driver links to each other with correct electropolar electrode can not guarantee safety.In the environment outside the clinic, when patient needed oneself to change the assembly of examining powder charge termly, this problem was just more outstanding.When patient tended to aging, it is more serious that this problem just becomes.
One object of the present invention is exactly to guarantee the medicine container of powder charge assembly and can polarity connecting correctly between the reusable controller that a plurality of powder charge assemblies use of electronic driver.
The objective of the invention is to guarantee in the electronic driver that the reusable controller that uses together with a plurality of disposable (for example, droppable) powder charge assembly is formed, to connect by correct electrode by one.After the assembly Chinese medicine of powder charge uses up, with unloading down on this assembly slave controller, throw away, change then one new.This 9 controller include an ambipolar power supply (such as: one or several battery), and selectively comprise the circuit of conduction time, frequency and an intensity etc. that are used for the control device electric current.The assembly of powder charge has first and second electrodes, has at least an electrode that treatment reagent to be transmitted (being medicine) is housed.
According to one embodiment of present invention, reusable controller should use at least the assembled joint of a conduction come to use with a limited number of time (such as: disposable) the powder charge assembly be coupled.This assembled joint has different sizes and/or different negative and positive counterparts is housed respectively on different parts, like this assembly of controller and powder charge can only be coupled in one way (that is to say correct polarity connection).
An alternative embodiment of the invention is, wants the parts of a protrusion on the assembly of controller or powder charge, does a corresponding hole on another.The position in the parts that protrude and the hole of respective shapes makes the assembly of controller and powder charge can only be coupled in one way (that is to say that correct polarity connects).
Identical parts are given identical reference number among the figure, wherein
Fig. 1 is the perspective view that has the electronic driver of a reusable controller and an isolating powder charge assembly.These two parts separate among this figure, and these two parts are coupled according to the present invention.
Fig. 2 is the cross-sectional view of Fig. 1 device, displaying be the assembly of controller and the powder charge structure when being coupled.
Fig. 3 is the perspective view that has the electronic driver of a reusable controller and an isolating powder charge assembly.These two parts separate among this figure, and these two parts another kind of embodiment according to the present invention is coupled.
Fig. 4 is the perspective view that has the electronic driver of a reusable controller and an isolating powder charge assembly.These two parts separate among this figure, and they are coupled according to an alternative embodiment of the invention.
Fig. 5 is the controller of another electronic driver and the perspective view of powder charge components apart.The assembly and the controller of powder charge are slidably engaged.
Fig. 6 is the device middle controller of Fig. 5 and the powder charge assembly bottom view when being coupled.
Fig. 7 is the cutaway view that the line 7-7 in Fig. 6 cuts the device in Fig. 5 and 6.
Fig. 8 is the perspective view that has the electronic driver of a reusable controller and an isolating powder charge assembly.These two parts separate among this figure, and they are coupled according to an alternative embodiment of the invention.
Fig. 9 is the top view of powder charge assembly according to another embodiment of the invention.
Figure 10 is the side view of the powder charge assembly shown in Fig. 9.
Figure 11 is a perspective view of showing the assembly coupled modes of the powder charge of explanation in reusable device and Fig. 9 and 10.
Figure 12 is the top view of the coupled system shown in Figure 11.
Figure 13 is the top view of coupled Electric Drive System according to another embodiment of the invention.
Figure 14 is the top view of the powder charge assembly among Figure 13.
Figure 15 is the side view of the powder charge assembly among Figure 14, and the parts that have draw with the form of sectional view.
Figure 16 is the top view of Electric Drive System according to another embodiment of the invention.
Figure 17 is the top view of the powder charge assembly of system shown in Figure 16.
Figure 18 shows is the perspective view of the coupled modes of the reusable controller of the system of explanation in Figure 16 and 17 and powder charge assembly.
Fig. 1 is the perspective view of electronic driver 10, includes a reusable electronic controller 12, can be coupled with powder charge assembly 30 or separate.Controller 12 is can be reusable, that is to say, it can use with the assembly 30 of a plurality of powder charges, for example, and series of identical or proximate powder charge assembly 30.On the other hand, the assembly 30 of powder charge has only the limited operating period usually, is suitable for after using, that is to say that working as the medicine of being adorned uses up after, it is scrapped.
Like this, alms giver's joint pin 36 and jack 26 have just been formed the joint of a press-button type, and this joint makes the output of circuit of circuit board 22 link to each other with the donor electrode of powder charge.Similarly, anti-joint pin 38 and jack 28 are also formed one by behaviour's formula joint, and this joint makes that the output of circuit and the antielectrode 34 of loading electrolyte are connected on the circuit board 22.The joint of two press-button types is except having the above-described effect that is electrically connected, also for providing a kind of separable (that is, impermanent) mechanical connection between the assembly 30 of powder charge and the controller 12.
Two outputs of the circuit on the circuit board 22 have different polarity, and promptly one just is output as, and should link to each other with the anode of powder charge assembly 30; Another is output as negative, should link to each other with the negative electrode of powder charge assembly 30.Polarity was correct when two electrodes must guaranteeing powder charge assembly 30 linked to each other with controller output end, (that is to say inverse time because if polarity connect, if the positive output end of circuit is linked to each other with negative electrode, and when the negative output terminal of circuit linked to each other with anode), electronic driver can transmit medicament hardly.The present invention has guaranteed that correct polarity connects, and in fact polarity can not wrong (promptly connecing anti-) between controller 12 and the powder charge assembly 30.Can be clear that from Fig. 1 and Fig. 2 the diameter of joint pin 36 is bigger than the diameter of joint pin 38.Equally, the internal diameter of jack 28 is bigger than the internal diameter of jack 28.Best, the internal diameter of jack 28 so just can not insert joint pin 36 in the jack 28 less than the diameter of joint pin 36.
According to this embodiment of the present invention, pin 36 and 38 has different sizes.Those skilled in the art know that pin 36 is with 38 except size (being diameter) is different, their shape (for example cross section or other shape) also can have enough difference, connects thereby guarantee can only carry out between controller 12 and the powder charge assembly 39 correct polarity.
Another kind of assurance controller has been described among Fig. 3 and have the alms giver and the powder charge assembly of antielectrode between the method that connects of correct polarity.Reusable controller 12 ' can link to each other with one or more powder charge assemblies 40 respectively.Powder charge assembly 40 has alms giver's joint pin 42, its effect and Fig. 1, and the alms giver's joint pin 36 in 2 is similar.But different with powder charge assembly 30 is that powder charge assembly 40 has a jack 44, the electric connection of antielectrode (not drawing among the figure) in it and the powder charge assembly 40.Jack 44 can engage with the joint pin that stretch out slave controller 12 ' bottom.Like this, powder charge assembly 30 has the positive counterpart (that is, joint pin 42) of a press-button type joint and the cloudy counterpart (that is, jack 44) of a press-button type joint simultaneously.These two press-button type joints are that powder charge assembly 40 and controller 12 ' provide machinery and electric dual coupling.On powder charge assembly 40 and controller 12 ', all join a male contact and a famale connector, can only be coupled by a kind of mode between controller 12 ' and the powder charge assembly 40 like this, just can only be by correct polar phase coupling.
Shown in Figure 4 is by a reusable controller 12 " and the electronic driver that powder charge assembly 50 constitutes.Different with the device 10 shown in Fig. 1 and 2 is reusable controller 12 " there be the 3rd press-button type jack to be used for accepting the 3rd joint pin 56 on the powder charge assembly 50.Like this, joint pin 52 and 54 roles in fact with device 10 in joint pin 36 with 38 the same.The size of supposing joint pin and jack all is identical with shape, then the position of the 3rd joint pin 56 and controller 12 " position of the jack (among the figure draw) of bottom joint pin 56, can not be equidistant with joint pin 52 and 54.Make joint pin 56 nearer than distance joint pin 52, then have only a kind of mode can allow powder charge assembly 50 and controller 12 apart from the distance of joint pin 54 " be connected promptly correct polarity connection.
Another kind of assurance controller 62 and powder charge assembly 80 correct coupled methods have been described among Fig. 5 to 7.Electronic driver 60 comprises a reusable controller 62, and this controller can be coupled with a plurality of same or similar powder charge assemblies 80 continuously.Shown in Fig. 7 is the cutaway view of controller 62 main bodys, draws conveniently in order to make, and shown is a whole cross section.Those skilled in the art know that controller 62 has a power supply and one and similar current control circuit shown in Fig. 2.Controller 62 has two circuit output 68 and 70, and these two outputs and electrode contacts 82 and 84 should be set up respectively and be electrically connected, and polarity was correct when sample can guarantee electrode 88 and 90 are connected with controller 62.Controller 62 includes a clip 64.Powder charge assembly 80 can insert the centre of clip 64 and controller 62.After powder charge assembly 80 inserts this position, groove 86 interlocks in joint pin 66 and the powder charge assembly 80, so just powder charge assembly 80 is located with respect to controller 62, thereby the output of circuit 68 contacts with electrode contacts 82, the output 70 of circuit contacts with electrode contacts 84.Between powder charge assembly and the controller 62 except plug-in type engages, also same press-button type joint guarantee between powder charge assembly 80 and the controller 62 reliably, but separable mechanical connection.This press-button type joint is made up of the joint pin 92 on jack on the controller 62 72 and the powder charge assembly 80.As shown in Figure 7, joint pin 92 inserts in the jack 72.
Shown in Figure 8 is a kind of mode that guarantees that polarity correct between controller 112 and the powder charge assembly 130 connects.Electronic driver 110 comprises a controller 112 that can be continuously be coupled with a plurality of same or similar powder charge assemblies 130.Controller 112 comprises a power supply and one and Fig. 1, the controller 12 similar current control circuits shown in 2.Controller 112 has two jacks (not drawing among Fig. 8) to engage with the joint pin 136 and 138 of powder charge assembly 130.Different with device shown in Fig. 1,2 is that joint pin 136 and 138 is measure-alike.In order to guarantee that joint pin 136 and 138 can engage with the correct jack in controller 112 bottoms, outstanding parts 134 are arranged on the surface of powder charge assembly 130, it is against the bottom of controller 112.As shown in Figure 8, projecting part 134 is quadrate, and it can engage with the square opening (not drawing among Fig. 8) of controller 112 bottoms.Those skilled in the art think that projecting part 134 can have many different shapes, as triangle, rectangle, circle, semicircle etc., and should exceed much enough than the surface of powder charge assembly 130, attempt powder charge assembly 130 and controller are carried out incorrect polarity when being connected as patient guaranteeing, joint pin 138 can not engage with the incorrect jack of controller 112.Preferably projecting part 134 is installed on the higher beam part of rigidity 132.Importantly the projecting part 134 on the crossbeam 132 is not positioned on the mid point of line of joint pin 136 and 138, to guarantee having only a kind of (that is, correct) polarity to connect between controller 112 and powder charge assembly 130.
An embodiment of the electronic driver of being made up of controller 212 210 shown in Fig. 9 to 12, this controller can be coupled with a plurality of same or similar powder charge assemblies 230 continuously.Shown in Fig. 9,10, powder charge assembly 230 has a pair of joint pin 236,238, and they can engage (not drawing among the figure) with the jack below the controller 212.Joint pin 236,238 preferably is contained on the inflexible beam part 232.The projecting part 234 that a wedge shape is arranged on beam part 232.Shown in Figure 11 and 12, breach 235 its shape and size that controller has a wedge type all match with the projecting part 234 of wedge type.Outstanding parts 234 and breach 235 provide key (lock and key) structure intuitively, thereby guide the user that controller 212 and powder charge assembly 212 are coupled with correct polarity intuitively.Higher if desired reliability, controller 212 can be made such mode: projecting part 234 inserts in the controller 212, and with the switch closure in the controller 212, thereby closed circuit makes this device that the electric drive electric current is passed to patient.When projecting part 234 takes off from breach 235, switch opens, the medicament of electric drive transmits and stops.
Shown in Figure 13 to 15 is the electronic driver 310 that comprises reusable controller 312, and this controller can be coupled with a series of identical or similar powder charge assembly 330.Powder charge assembly 330 has a socket 334, is used for engaging with an end of controller 312.The position of press-button type joint is used for guaranteeing: have only when controller 312 1 ends insert socket 334, electrical couplings just can take place with powder charge assembly 330 in controller 312.In other words, the shape of socket 334 and size can only allow it to receive a certain end of controller 312.This selective engagement mode of controller 312 can be realized by any known mode; Comprise that the size at the two ends that suitably change controller 312 and/or shape are or/and provide certain suitable keying mechanism (not shown).Adopt this mode, controller 312 has only an end to engage with socket 334, has so just guaranteed to adopt foregoing press-button type joint to carry out polarity correct between controller 312 and the powder charge assembly 330 and has connected.
Shown in Figure 16 to 18 is another kind of embodiment of the present invention.The same with the system shown in Figure 13 to 15, electric drive is adorned 410 and is comprised controller 412, this controller can only insert in the socket 434 of powder charge assembly 430 with a direction, and this is because the two ends shape (end is flat, and an end is round) inequality of controller 412 and socket 434.The end that socket 434 is only made with controller 412 is complementary, and has only a kind of (just, correct) polarity connected mode like this between controller 412 and the powder charge assembly 430.
Although several embodiment that polarity correct between several controllers of guaranteeing electronic driver and the powder charge assembly that has alms giver and antielectrode is connected have been described in the detailed description of front, but be to be appreciated that above explanation only is the explanation to invention of the present disclosure, rather than limit it.Can know that within the scope and spirit of the present invention those skilled in the art can and change to this disclosed coupling device in shape in material, size, type, or increase or remove some parts.Therefore, the present invention is only limited by following claims.
Claims (27)
1. an electronic driver (10) is used for transmitting medicament and makes its body surface that enters patient, and this device (10) comprising: an assembly (30) that has first and second electrodes (31,32 and 33,34) wherein has at least an electrode that medicament to be transmitted is housed; A controller (12) that has bipolar power supply (20) is used for providing electric current into electrode (31,32 and 33,34); Coupling device (36,26 and 38,28), be used for controller (12) and assembly (30) are carried out electrical couplings and uncoupling, this electronic driver is characterised in that its coupling device, and this device allows first electrode (31,32) to be connected with the predetermined utmost point of bipolar power supply (20), and can stop first electrode (31,32) to be connected with another utmost point of bipolar power supply (20).
2. the device of claim 1, wherein coupling device allow second electrode (33,34) and bipolar power supply (20) another extremely link to each other, and can stop it to be connected with the predetermined utmost point of bipolar power supply (20).
3. the device of claim 1, wherein the predetermined utmost point of bipolar power supply (20) is anodal, and coupled electrode is an anode, and medicament is a cation.
4. the device of claim 1, wherein, the predetermined utmost point of bipolar power supply (20) is a negative pole, and coupled electrode is a negative electrode, and medicament is an anion.
5. the device of claim 1, wherein coupling device comprises the press-button type joint (36,26 and 38,28) of pair of conductive.
6. the device of claim 5, wherein press-button type joint (36,26 and 38,28) is to be made of a kind of material of selecting from the group of metal and carbon combination.
7. the device of claim 6, wherein metal is to select from the group that is made up by silver and rustless steel.
8. the device of claim 1, wherein coupling device also provides the mechanical couplings between assembly (30) and the controller (12).
9. the device of claim 1, wherein coupling device comprises: first bonder (36,26) that has the moon (26) and sun (36) pairing assembly; When the pairing assembly (36,26) of first bonder when connecting, with anastomosing first electrode of power supply (20) (31,32); Second bonder (38,28) that has the moon (28) and sun (38) pairing assembly; When the pairing assembly (38,28) of second bonder when connecting, with anastomosing second electrode of power supply (20) (33,34), and wherein the sun pairing assembly (36) of first bonder can not be coupled with the moon pairing assembly (28) of second bonder.
10. the device of claim 1, wherein coupling device comprises: have first and second first bonders to (52,54) yin, yang pairing assembly; When two pairs of yin, yangs match assemblies (52,54) when connecting, with anastomosing first electrode of power supply (20) (31,32); Second bonder that has the 3rd pair of yin, yang pairing assembly (56); When the 3rd pair of yin, yang pairing assembly connected, with power connection second electrode, and wherein the position of three pairs of yin, yang pairing assemblies only allowed to exist between assembly (50) and the controller (12 ") a kind of electrical connection of mode.
11. the device of claim 10, wherein in order to be electrically connected first electrode and power supply, first, second pairing assembly must all connect.
12. the device of claim 10 wherein has only first pair of pairing assembly to connect in order to be electrically connected first electrode and power supply; The second pair of pairing assembly provides mechanically coupling for assembly and controller.
13. the device of claim 1, wherein coupling device comprises: first bonder (44) that has yin, yang pairing assembly; When the pairing assembly (44) of first bonder when connecting, with first electrode (31,32) of power connection; Second bonder (42) that has yin, yang pairing assembly; When the pairing assembly of second bonder (42) connects, with anastomosing second electrode (33 of power supply (20), 34), and wherein the positive counterpart on first bonder is positioned on the controller (12 '), and the positive counterpart of second bonder is positioned on the assembly (40).
14. the device of claim 1, wherein coupling device comprises: first bonder that has yin, yang pairing assembly; When the pairing assembly of first bonder connects, with first electrode of power connection; Second bonder that has yin, yang pairing assembly; When the pairing assembly of second bonder connects, with second electrode of power connection, and wherein on first bonder cloudy counterpart be positioned on the controller; And the cloudy counterpart on second bonder is positioned on the assembly.
15. the device of claim 1, wherein coupling device comprises: first bonder that has the outer assembly of yin, yang pairing; When the pairing assembly of first bonder connects, with first electrode of power connection; Second bonder that has yin, yang pairing assembly; When the pairing assembly of second bonder connects, with second electrode of power connection; When the positive counterpart of first bonder is connected with the cloudy counterpart of second bonder, when the cloudy counterpart of first bonder is connected with the positive counterpart of second bonder, the position of pairing assembly will make controller and assembly be in one and suspend/orientation of misalignment on.
16. the device of claim 1, wherein ambipolar power supply (20) comprises a battery.
17. the device of claim 1, wherein assembly (30) is scrapped after using once.
18. the device of claim 1, its middle controller (12) can be coupled with a plurality of assemblies (30) continuously.
19. a kind of method of assembly (30) and controller (12) electrical couplings, assembly (30) has first and second electrodes (31,21 and 33,34), and have at least an electrode that medicament to be transmitted is housed, controller (12) has an ambipolar power supply (20), be used for providing electric current for electrode (31,32 and 33,34), this method comprises by a coupling device (36,26 and 38,28) can carry out electric coupling or remove electric coupling controller (12) and assembly (30), this coupling device allows first electrode (31,32), and prevent that another utmost point of first electrode and bipolar power supply is electrically connected with predetermined extremely the linking to each other of bipolar power supply (20).
20. the method for claim 19, the coupling of its middle controller (12) and assembly (30) realizes by the press-button type joint (36,26) of conduction.
21. the method for claim 19, the coupling of its middle controller (12) and assembly (30) realizes by the press-button type joint (36,26 and 38,28) of conduction.
22. the method for claim 19, wherein bipolar power supply (20) comprises a battery.
23. the method for claim 19, comprise take off on assembly (30) slave controller (12) after, assembly (30) is scrapped.
24. the method for claim 19 comprises controller (12) one at a time, is coupled with a plurality of assemblies (30) continuously.
25. the device of claim 1, wherein coupling device comprises the parts of a protrusion on controller (112) or assembly (130).
26. the device of claim 25, wherein the parts of Tu Chuing can be meshed with the opening on another person in assembly (130) and the controller (112).
27. the device of claim 1, wherein the coupling device on the assembly (330,430) comprises socket (334,434), and its middle controller (312,412) can only be coupled in one direction with socket (334,434).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44080395A | 1995-05-15 | 1995-05-15 | |
| US08/440,803 | 1995-05-15 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1184433A true CN1184433A (en) | 1998-06-10 |
| CN1104917C CN1104917C (en) | 2003-04-09 |
Family
ID=23750242
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN96193927.3A Expired - Fee Related CN1104917C (en) | 1995-05-15 | 1996-05-01 | Electrotransport device having reusable controller |
Country Status (14)
| Country | Link |
|---|---|
| JP (4) | JPH11505158A (en) |
| CN (1) | CN1104917C (en) |
| AU (1) | AU714537C (en) |
| BE (1) | BE1009855A5 (en) |
| CA (1) | CA2216731C (en) |
| CH (1) | CH693606A5 (en) |
| DE (1) | DE19681392B4 (en) |
| FR (1) | FR2734162B1 (en) |
| GB (1) | GB2317343B (en) |
| IE (1) | IE960331A1 (en) |
| IT (1) | IT1285873B1 (en) |
| MX (1) | MX9708823A (en) |
| NL (1) | NL1003109C2 (en) |
| WO (1) | WO1996036394A1 (en) |
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|---|---|---|---|---|
| CN104739398A (en) * | 2012-12-31 | 2015-07-01 | 松拓有限公司 | Male end of a telemetric transceiver |
| CN108635667A (en) * | 2018-05-11 | 2018-10-12 | 英纳伟通 Ab | A kind of medical treatment device |
| US11058338B2 (en) | 2012-12-31 | 2021-07-13 | Suunto Oy | Electrode assembly |
| US11944441B2 (en) | 2012-12-31 | 2024-04-02 | Suunto Oy | Electro-mechanic assembly and integrated snap connectors |
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| US8454543B2 (en) * | 2004-03-10 | 2013-06-04 | Vision Quest Industries Incorporated | Electrodes for orthotic device |
| JP2010522041A (en) * | 2007-03-22 | 2010-07-01 | アルザ・コーポレーシヨン | Multi-part electrotransport drug delivery device |
| WO2009046989A2 (en) | 2007-10-11 | 2009-04-16 | Roche Diagnostics Gmbh | Carrier for an infusion system |
| US8190252B2 (en) | 2009-02-12 | 2012-05-29 | Incube Labs, Llc | Iontophoretic system for transdermal delivery of active agents for therapeutic and medicinal purposes |
| WO2011044175A2 (en) | 2009-10-06 | 2011-04-14 | Incube Labs, Llc | Patch and patch assembly for iontophoretic transdermal delivery of active agents for therapeutic and medicinal purposes |
| US8685038B2 (en) | 2009-12-07 | 2014-04-01 | Incube Labs, Llc | Iontophoretic apparatus and method for marking of the skin |
| US8747383B2 (en) | 2009-12-18 | 2014-06-10 | University Medical Pharmaceuticals Corp. | Process and system for iontophoretic wrinkle reduction |
| WO2011139779A1 (en) * | 2010-04-27 | 2011-11-10 | Ndi Medical,Llc | Systems and methods for percutaneous electrical stimulation |
| WO2012129576A2 (en) | 2011-03-24 | 2012-09-27 | Incube Labs, Llc | System and method for biphasic transdermal iontophreotic delivery of therapeutic agents |
| US8428709B1 (en) | 2012-06-11 | 2013-04-23 | Incline Therapeutics, Inc. | Current control for electrotransport drug delivery |
| US8428708B1 (en) | 2012-05-21 | 2013-04-23 | Incline Therapeutics, Inc. | Self-test for analgesic product |
| US8301238B2 (en) | 2011-03-31 | 2012-10-30 | Incline Therapeutics, Inc. | Two-part electrotransport device |
| WO2012154704A2 (en) | 2011-05-06 | 2012-11-15 | Incube Labs, Llc | System and method for biphasic transdermal iontophoretic delivery of therapeutic agents for the control of addictive cravings |
| KR102691282B1 (en) * | 2022-05-19 | 2024-08-05 | 주식회사 밀알 | Electroporation dispenser with disposable cartridge |
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| US4856188A (en) * | 1984-10-12 | 1989-08-15 | Drug Delivery Systems Inc. | Method for making disposable and/or replenishable transdermal drug applicators |
| JPS60145583U (en) * | 1984-03-05 | 1985-09-27 | 日本電気株式会社 | integrated circuit socket |
| IL86076A (en) * | 1988-04-14 | 1992-12-01 | Inventor S Funding Corp Ltd | Transdermal drug delivery device |
| US5320597A (en) * | 1991-02-08 | 1994-06-14 | Becton, Dickinson And Company | Device and method for renewing electrodes during iontophoresis |
| IT1244030B (en) * | 1989-12-21 | 1994-06-28 | Elan Corp Plc | TWO-PART DEVICE FOR THE CONTROLLED ADMINISTRATION OF AN INGREDIENT |
| JPH0561977U (en) * | 1992-01-23 | 1993-08-13 | 昭和電線電纜株式会社 | Plug-in connection |
| JPH0631088U (en) * | 1992-09-28 | 1994-04-22 | 日本エー・エム・ピー株式会社 | Edge connector and contactor used for it |
| US5445609A (en) * | 1993-05-28 | 1995-08-29 | Alza Corporation | Electrotransport agent delivery device having a disposable component and a removable liner |
| US5458569A (en) * | 1993-06-08 | 1995-10-17 | Becton Dickinson And Company | Wearable iontophoresis system |
| FR2709670B1 (en) * | 1993-09-10 | 1995-10-20 | Asulab Sa | Device in three modules for transdermal administration of drugs by electrophoresis or iontophoresis. |
| US5562607A (en) * | 1995-01-18 | 1996-10-08 | Alza Corporation | Electrotransport device having reusable controller power saver |
-
1996
- 1996-05-01 GB GB9724264A patent/GB2317343B/en not_active Expired - Fee Related
- 1996-05-01 JP JP8534863A patent/JPH11505158A/en active Pending
- 1996-05-01 CN CN96193927.3A patent/CN1104917C/en not_active Expired - Fee Related
- 1996-05-01 DE DE19681392T patent/DE19681392B4/en not_active Expired - Fee Related
- 1996-05-01 MX MX9708823A patent/MX9708823A/en unknown
- 1996-05-01 CH CH02675/97A patent/CH693606A5/en not_active IP Right Cessation
- 1996-05-01 AU AU58522/96A patent/AU714537C/en not_active Ceased
- 1996-05-01 WO PCT/US1996/006098 patent/WO1996036394A1/en active Application Filing
- 1996-05-01 CA CA002216731A patent/CA2216731C/en not_active Expired - Fee Related
- 1996-05-03 IE IE960331A patent/IE960331A1/en not_active IP Right Cessation
- 1996-05-14 NL NL1003109A patent/NL1003109C2/en not_active IP Right Cessation
- 1996-05-14 IT IT96TO000397A patent/IT1285873B1/en active IP Right Grant
- 1996-05-14 FR FR9605972A patent/FR2734162B1/en not_active Expired - Fee Related
- 1996-05-15 BE BE9600441A patent/BE1009855A5/en not_active IP Right Cessation
-
2006
- 2006-07-03 JP JP2006182984A patent/JP2006297132A/en active Pending
-
2007
- 2007-12-03 JP JP2007311923A patent/JP2008100096A/en active Pending
-
2008
- 2008-10-22 JP JP2008271620A patent/JP2009039557A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104739398A (en) * | 2012-12-31 | 2015-07-01 | 松拓有限公司 | Male end of a telemetric transceiver |
| CN104739398B (en) * | 2012-12-31 | 2017-11-17 | 松拓有限公司 | Telemetry transceiver male end |
| US11058338B2 (en) | 2012-12-31 | 2021-07-13 | Suunto Oy | Electrode assembly |
| US11944441B2 (en) | 2012-12-31 | 2024-04-02 | Suunto Oy | Electro-mechanic assembly and integrated snap connectors |
| CN108635667A (en) * | 2018-05-11 | 2018-10-12 | 英纳伟通 Ab | A kind of medical treatment device |
Also Published As
| Publication number | Publication date |
|---|---|
| IT1285873B1 (en) | 1998-06-24 |
| ITTO960397A1 (en) | 1997-11-14 |
| IE960331A1 (en) | 1996-11-27 |
| ITTO960397A0 (en) | 1996-05-14 |
| FR2734162A1 (en) | 1996-11-22 |
| MX9708823A (en) | 1998-02-28 |
| NL1003109A1 (en) | 1996-11-18 |
| AU5852296A (en) | 1996-11-29 |
| JPH11505158A (en) | 1999-05-18 |
| CN1104917C (en) | 2003-04-09 |
| AU714537B2 (en) | 2000-01-06 |
| JP2006297132A (en) | 2006-11-02 |
| GB2317343A (en) | 1998-03-25 |
| NL1003109C2 (en) | 1998-04-02 |
| JP2008100096A (en) | 2008-05-01 |
| DE19681392B4 (en) | 2008-10-23 |
| CA2216731A1 (en) | 1996-11-21 |
| WO1996036394A1 (en) | 1996-11-21 |
| DE19681392T1 (en) | 1998-04-23 |
| GB9724264D0 (en) | 1998-01-14 |
| GB2317343B (en) | 1999-06-23 |
| CH693606A5 (en) | 2003-11-14 |
| BE1009855A5 (en) | 1997-10-07 |
| FR2734162B1 (en) | 1999-01-22 |
| CA2216731C (en) | 2008-11-25 |
| AU714537C (en) | 2001-11-08 |
| JP2009039557A (en) | 2009-02-26 |
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Granted publication date: 20030409 Termination date: 20110501 |