CN118355033A - 包含抗NRP2a抗体的组合物和方法 - Google Patents

包含抗NRP2a抗体的组合物和方法 Download PDF

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Publication number
CN118355033A
CN118355033A CN202280080506.0A CN202280080506A CN118355033A CN 118355033 A CN118355033 A CN 118355033A CN 202280080506 A CN202280080506 A CN 202280080506A CN 118355033 A CN118355033 A CN 118355033A
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CN
China
Prior art keywords
cancer
antigen
antibody
optionally
seq
Prior art date
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Pending
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CN202280080506.0A
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English (en)
Chinese (zh)
Inventor
卢克·G·博尔曼
张宇婷
凯特琳·劳奇
莱斯利·A·南格尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
aTyr Pharma Inc
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aTyr Pharma Inc
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Publication date
Application filed by aTyr Pharma Inc filed Critical aTyr Pharma Inc
Publication of CN118355033A publication Critical patent/CN118355033A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN202280080506.0A 2021-10-27 2022-10-27 包含抗NRP2a抗体的组合物和方法 Pending CN118355033A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163272374P 2021-10-27 2021-10-27
US63/272,374 2021-10-27
PCT/US2022/078780 WO2023076998A1 (en) 2021-10-27 2022-10-27 COMPOSITIONS AND METHODS COMPRISING ANTI-NRP2a ANTIBODIES

Publications (1)

Publication Number Publication Date
CN118355033A true CN118355033A (zh) 2024-07-16

Family

ID=86158721

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202280080506.0A Pending CN118355033A (zh) 2021-10-27 2022-10-27 包含抗NRP2a抗体的组合物和方法

Country Status (7)

Country Link
US (1) US20240417476A1 (https=)
EP (1) EP4423142A4 (https=)
JP (1) JP2024540083A (https=)
CN (1) CN118355033A (https=)
AU (1) AU2022375785A1 (https=)
CA (1) CA3234409A1 (https=)
WO (1) WO2023076998A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2019247511B2 (en) 2018-04-06 2025-10-16 Atyr Pharma, Inc. Compositions and methods comprising anti-NRP2 antibodies
CA3156803A1 (en) 2019-10-03 2021-04-08 Atyr Pharma, Inc. Compositions and methods comprising anti-nrp2 antibodies

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7420040B2 (en) * 2006-02-24 2008-09-02 Arius Research Inc. Cytotoxicity mediation of cells evidencing surface expression of TROP-2
AR068723A1 (es) * 2007-10-05 2009-12-02 Glaxo Group Ltd Proteina que se une a antigenos que se une a il-23 humana y sus usos
TWI541021B (zh) * 2009-03-05 2016-07-11 艾伯維有限公司 Ｉｌ－１７結合蛋白
CN102459335B (zh) * 2009-04-17 2015-11-25 伊缪纳斯制药株式会社 特异性结合Aβ寡聚体的抗体及其用途
WO2012144208A1 (ja) * 2011-04-18 2012-10-26 国立大学法人東京大学 抗itm2a抗体を用いる癌の診断および治療
CA2896058A1 (en) * 2012-12-24 2014-07-03 Abbvie Inc. Prolactin receptor binding proteins and uses thereof
KR20160131082A (ko) * 2014-03-12 2016-11-15 프로테나 바이오사이언시즈 리미티드 Lg1-3에 특이적인 항-라미닌4 항체
EP3464349A4 (en) * 2016-05-23 2020-08-26 New York University COMPOSITIONS AND METHODS ASSOCIATED WITH ANTIBODIES TARGETING STAPHYLOCCAL LEUCOTOXINS
KR102758204B1 (ko) * 2017-10-30 2025-01-23 밀테니 비오텍 비.브이. & 씨오. 케이지 표적 세포의 선택적 형질도입을 위한 어댑터-기반 레트로바이러스 벡터 시스템
AU2019247511B2 (en) * 2018-04-06 2025-10-16 Atyr Pharma, Inc. Compositions and methods comprising anti-NRP2 antibodies
KR20210148216A (ko) * 2019-04-01 2021-12-07 지앙수 헨그루이 메디슨 컴퍼니 리미티드 항-클라우딘 18.2 항체 및 이의 응용
WO2021058548A1 (en) * 2019-09-23 2021-04-01 Centro Nacional De Investigaciones Cardiovasculares Carlos Iii (F.S.P.) Antibodies for the diagnosis and/or treatment of atherosclerosis
CA3156803A1 (en) * 2019-10-03 2021-04-08 Atyr Pharma, Inc. Compositions and methods comprising anti-nrp2 antibodies
CN116075525A (zh) * 2020-03-31 2023-05-05 艾莱克特有限责任公司 抗mertk抗体及其使用方法

Also Published As

Publication number Publication date
EP4423142A1 (en) 2024-09-04
US20240417476A1 (en) 2024-12-19
AU2022375785A1 (en) 2024-04-11
EP4423142A4 (en) 2025-10-22
CA3234409A1 (en) 2023-05-04
WO2023076998A1 (en) 2023-05-04
JP2024540083A (ja) 2024-10-31

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SE01 Entry into force of request for substantive examination
CB03 Change of inventor or designer information
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Inventor after: Luke G. Borman

Inventor after: Zhang Yuting

Inventor after: Caitlin lauch

Inventor after: Leslie Ann Green

Inventor before: Luke G. Borman

Inventor before: Zhang Yuting

Inventor before: Caitlin lauch

Inventor before: Leslie A. Nagel