CN118286338A - Traditional Chinese medicine composition, preparation method and application thereof, and nutritional medicated diet and preparation method - Google Patents
Traditional Chinese medicine composition, preparation method and application thereof, and nutritional medicated diet and preparation method Download PDFInfo
- Publication number
- CN118286338A CN118286338A CN202410454593.2A CN202410454593A CN118286338A CN 118286338 A CN118286338 A CN 118286338A CN 202410454593 A CN202410454593 A CN 202410454593A CN 118286338 A CN118286338 A CN 118286338A
- Authority
- CN
- China
- Prior art keywords
- parts
- traditional chinese
- chinese medicine
- medicine composition
- raw materials
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 69
- 239000000203 mixture Substances 0.000 title claims abstract description 68
- 235000005911 diet Nutrition 0.000 title claims abstract description 28
- 230000037213 diet Effects 0.000 title claims abstract description 28
- 235000016709 nutrition Nutrition 0.000 title claims abstract description 27
- 238000002360 preparation method Methods 0.000 title claims abstract description 25
- 239000002994 raw material Substances 0.000 claims abstract description 51
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 43
- 210000000952 spleen Anatomy 0.000 claims abstract description 35
- 239000008280 blood Substances 0.000 claims abstract description 25
- 210000004369 blood Anatomy 0.000 claims abstract description 23
- 241000221638 Morchella Species 0.000 claims abstract description 17
- 244000268590 Euryale ferox Species 0.000 claims abstract description 12
- 235000011194 food seasoning agent Nutrition 0.000 claims abstract description 12
- 241001264174 Cordyceps militaris Species 0.000 claims abstract description 11
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 11
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 11
- 235000008434 ginseng Nutrition 0.000 claims abstract description 11
- 150000003839 salts Chemical class 0.000 claims abstract description 11
- 235000020997 lean meat Nutrition 0.000 claims abstract description 9
- 244000131316 Panax pseudoginseng Species 0.000 claims abstract 2
- 238000002156 mixing Methods 0.000 claims description 31
- 238000000855 fermentation Methods 0.000 claims description 27
- 230000004151 fermentation Effects 0.000 claims description 27
- 239000000284 extract Substances 0.000 claims description 20
- 241000186660 Lactobacillus Species 0.000 claims description 19
- 244000126002 Ziziphus vulgaris Species 0.000 claims description 19
- 238000001914 filtration Methods 0.000 claims description 19
- 229940039696 lactobacillus Drugs 0.000 claims description 19
- 235000006545 Ziziphus mauritiana Nutrition 0.000 claims description 15
- 235000008529 Ziziphus vulgaris Nutrition 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 14
- 238000001694 spray drying Methods 0.000 claims description 12
- 240000002853 Nelumbo nucifera Species 0.000 claims description 11
- 235000006508 Nelumbo nucifera Nutrition 0.000 claims description 11
- 235000006510 Nelumbo pentapetala Nutrition 0.000 claims description 11
- 244000197580 Poria cocos Species 0.000 claims description 11
- 235000008599 Poria cocos Nutrition 0.000 claims description 11
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 11
- 229930006000 Sucrose Natural products 0.000 claims description 11
- 229940079593 drug Drugs 0.000 claims description 11
- 235000013399 edible fruits Nutrition 0.000 claims description 11
- 239000005720 sucrose Substances 0.000 claims description 11
- 244000119298 Emblica officinalis Species 0.000 claims description 10
- 235000015489 Emblica officinalis Nutrition 0.000 claims description 10
- 235000017784 Mespilus germanica Nutrition 0.000 claims description 10
- 235000000560 Mimusops elengi Nutrition 0.000 claims description 10
- 235000007837 Vangueria infausta Nutrition 0.000 claims description 10
- 244000303040 Glycyrrhiza glabra Species 0.000 claims description 9
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims description 9
- 238000011081 inoculation Methods 0.000 claims description 9
- 238000010298 pulverizing process Methods 0.000 claims description 9
- 241001061264 Astragalus Species 0.000 claims description 8
- 235000006533 astragalus Nutrition 0.000 claims description 8
- 235000004879 dioscorea Nutrition 0.000 claims description 8
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims description 8
- 235000011477 liquorice Nutrition 0.000 claims description 8
- 238000005728 strengthening Methods 0.000 claims description 8
- 210000004233 talus Anatomy 0.000 claims description 8
- 244000061520 Angelica archangelica Species 0.000 claims description 7
- 235000001287 Guettarda speciosa Nutrition 0.000 claims description 7
- 244000182216 Mimusops elengi Species 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 35
- 239000000463 material Substances 0.000 abstract description 10
- 235000006487 Euryale ferox Nutrition 0.000 abstract description 7
- 235000015277 pork Nutrition 0.000 abstract description 7
- 240000002769 Morchella esculenta Species 0.000 abstract description 5
- 235000002779 Morchella esculenta Nutrition 0.000 abstract description 5
- 235000014347 soups Nutrition 0.000 abstract description 5
- 210000001124 body fluid Anatomy 0.000 abstract description 4
- 239000010839 body fluid Substances 0.000 abstract description 4
- 238000004519 manufacturing process Methods 0.000 abstract description 4
- 235000013372 meat Nutrition 0.000 abstract description 4
- 230000035764 nutrition Effects 0.000 abstract description 4
- 230000036541 health Effects 0.000 abstract description 3
- 210000000582 semen Anatomy 0.000 abstract description 3
- 239000009636 Huang Qi Substances 0.000 abstract description 2
- 244000299461 Theobroma cacao Species 0.000 abstract description 2
- 235000009470 Theobroma cacao Nutrition 0.000 abstract description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract description 2
- 239000011707 mineral Substances 0.000 abstract description 2
- 238000012545 processing Methods 0.000 abstract description 2
- 235000013343 vitamin Nutrition 0.000 abstract description 2
- 229940088594 vitamin Drugs 0.000 abstract description 2
- 229930003231 vitamin Natural products 0.000 abstract description 2
- 239000011782 vitamin Substances 0.000 abstract description 2
- 241001619461 Poria <basidiomycete fungus> Species 0.000 abstract 1
- 239000009609 fructus phyllanthi Substances 0.000 abstract 1
- 235000013547 stew Nutrition 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 description 23
- 210000002784 stomach Anatomy 0.000 description 14
- 235000009508 confectionery Nutrition 0.000 description 13
- 230000001737 promoting effect Effects 0.000 description 13
- 230000001105 regulatory effect Effects 0.000 description 12
- 206010062717 Increased upper airway secretion Diseases 0.000 description 10
- 208000026435 phlegm Diseases 0.000 description 10
- 206010012735 Diarrhoea Diseases 0.000 description 9
- 240000002624 Mespilus germanica Species 0.000 description 9
- 240000004371 Panax ginseng Species 0.000 description 9
- 230000013872 defecation Effects 0.000 description 9
- 210000003734 kidney Anatomy 0.000 description 8
- 208000024891 symptom Diseases 0.000 description 8
- 206010011224 Cough Diseases 0.000 description 7
- 206010033557 Palpitations Diseases 0.000 description 7
- 229960004192 diphenoxylate Drugs 0.000 description 7
- 210000004072 lung Anatomy 0.000 description 7
- 230000027939 micturition Effects 0.000 description 7
- 206010067484 Adverse reaction Diseases 0.000 description 6
- 206010024642 Listless Diseases 0.000 description 6
- 230000006838 adverse reaction Effects 0.000 description 6
- -1 compound diphenoxylate Chemical class 0.000 description 6
- 206010061428 decreased appetite Diseases 0.000 description 6
- 208000017971 listlessness Diseases 0.000 description 6
- 208000011580 syndromic disease Diseases 0.000 description 6
- 235000019640 taste Nutrition 0.000 description 6
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 5
- 206010022437 insomnia Diseases 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical class [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
- 208000002720 Malnutrition Diseases 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 4
- 206010067482 No adverse event Diseases 0.000 description 4
- 206010047700 Vomiting Diseases 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 4
- 208000022531 anorexia Diseases 0.000 description 4
- 208000002173 dizziness Diseases 0.000 description 4
- 230000007661 gastrointestinal function Effects 0.000 description 4
- 230000001071 malnutrition Effects 0.000 description 4
- 235000000824 malnutrition Nutrition 0.000 description 4
- 208000015380 nutritional deficiency disease Diseases 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 230000008673 vomiting Effects 0.000 description 4
- 244000215068 Acacia senegal Species 0.000 description 3
- 206010010774 Constipation Diseases 0.000 description 3
- 229920000084 Gum arabic Polymers 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 3
- 206010039424 Salivary hypersecretion Diseases 0.000 description 3
- 208000032023 Signs and Symptoms Diseases 0.000 description 3
- 235000010489 acacia gum Nutrition 0.000 description 3
- 239000000205 acacia gum Substances 0.000 description 3
- 230000036528 appetite Effects 0.000 description 3
- 235000019789 appetite Nutrition 0.000 description 3
- 235000021152 breakfast Nutrition 0.000 description 3
- 206010012601 diabetes mellitus Diseases 0.000 description 3
- 238000004090 dissolution Methods 0.000 description 3
- 201000006549 dyspepsia Diseases 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 206010016256 fatigue Diseases 0.000 description 3
- 239000012467 final product Substances 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 210000002216 heart Anatomy 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- 238000010172 mouse model Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 208000026451 salivation Diseases 0.000 description 3
- 239000011885 synergistic combination Substances 0.000 description 3
- 230000002936 tranquilizing effect Effects 0.000 description 3
- 238000005303 weighing Methods 0.000 description 3
- 208000004998 Abdominal Pain Diseases 0.000 description 2
- 208000000044 Amnesia Diseases 0.000 description 2
- 208000031091 Amnestic disease Diseases 0.000 description 2
- 241000213006 Angelica dahurica Species 0.000 description 2
- 206010003591 Ataxia Diseases 0.000 description 2
- 206010007247 Carbuncle Diseases 0.000 description 2
- 208000017667 Chronic Disease Diseases 0.000 description 2
- 206010010947 Coordination abnormal Diseases 0.000 description 2
- 235000002722 Dioscorea batatas Nutrition 0.000 description 2
- 235000006536 Dioscorea esculenta Nutrition 0.000 description 2
- 240000001811 Dioscorea oppositifolia Species 0.000 description 2
- 235000003416 Dioscorea oppositifolia Nutrition 0.000 description 2
- 206010013954 Dysphoria Diseases 0.000 description 2
- 208000000059 Dyspnea Diseases 0.000 description 2
- 206010013975 Dyspnoeas Diseases 0.000 description 2
- 208000008454 Hyperhidrosis Diseases 0.000 description 2
- 206010027514 Metrorrhagia Diseases 0.000 description 2
- 206010059013 Nocturnal emission Diseases 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 208000005392 Spasm Diseases 0.000 description 2
- 206010041497 Spermatorrhoea Diseases 0.000 description 2
- 230000006986 amnesia Effects 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 208000019902 chronic diarrheal disease Diseases 0.000 description 2
- 230000003750 conditioning effect Effects 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- 230000002124 endocrine Effects 0.000 description 2
- 210000003414 extremity Anatomy 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 238000003304 gavage Methods 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 208000016290 incoordination Diseases 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000002203 pretreatment Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 230000035900 sweating Effects 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- UIAGMCDKSXEBJQ-IBGZPJMESA-N 3-o-(2-methoxyethyl) 5-o-propan-2-yl (4s)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound COCCOC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)[C@H]1C1=CC=CC([N+]([O-])=O)=C1 UIAGMCDKSXEBJQ-IBGZPJMESA-N 0.000 description 1
- 206010000077 Abdominal mass Diseases 0.000 description 1
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 1
- 201000000736 Amenorrhea Diseases 0.000 description 1
- 206010001928 Amenorrhoea Diseases 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 206010006895 Cachexia Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 101100117236 Drosophila melanogaster speck gene Proteins 0.000 description 1
- 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 description 1
- 208000005171 Dysmenorrhea Diseases 0.000 description 1
- 206010013935 Dysmenorrhoea Diseases 0.000 description 1
- 208000008967 Enuresis Diseases 0.000 description 1
- 206010016100 Faeces discoloured Diseases 0.000 description 1
- 206010016807 Fluid retention Diseases 0.000 description 1
- 206010017943 Gastrointestinal conditions Diseases 0.000 description 1
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 description 1
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 208000006083 Hypokinesia Diseases 0.000 description 1
- 206010021118 Hypotonia Diseases 0.000 description 1
- 208000019255 Menstrual disease Diseases 0.000 description 1
- 208000019914 Mental Fatigue Diseases 0.000 description 1
- 208000036626 Mental retardation Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 206010062519 Poor quality sleep Diseases 0.000 description 1
- 206010067171 Regurgitation Diseases 0.000 description 1
- 206010042674 Swelling Diseases 0.000 description 1
- 208000009205 Tinnitus Diseases 0.000 description 1
- 206010070863 Toxicity to various agents Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 206010047513 Vision blurred Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 231100000540 amenorrhea Toxicity 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 229940107666 astragalus root Drugs 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- HYPPXZBJBPSRLK-UHFFFAOYSA-N diphenoxylate Chemical compound C1CC(C(=O)OCC)(C=2C=CC=CC=2)CCN1CCC(C#N)(C=1C=CC=CC=1)C1=CC=CC=C1 HYPPXZBJBPSRLK-UHFFFAOYSA-N 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 230000000517 effect on sleep Effects 0.000 description 1
- 208000026500 emaciation Diseases 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 208000017561 flaccidity Diseases 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 238000009499 grossing Methods 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 229940010454 licorice Drugs 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000004570 mortar (masonry) Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229960000715 nimodipine Drugs 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000000447 pesticide residue Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 208000008128 pulmonary tuberculosis Diseases 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 208000013220 shortness of breath Diseases 0.000 description 1
- 230000003860 sleep quality Effects 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 230000004206 stomach function Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 231100000886 tinnitus Toxicity 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
Abstract
The invention provides a traditional Chinese medicine composition, a preparation method and application thereof, and a nutritional medicated diet and a preparation method thereof, belonging to the technical field of traditional Chinese medicine processing. The invention provides a traditional Chinese medicine composition which comprises the following raw materials in parts by weight: morchella, zizyphi fructus, lycii Frutus, semen euryales, rhizoma Dioscoreae, semen Nelumbinis, fructus Phyllanthi, pericarpium Citri Tangerinae and Poria; or Morchella esculenta, glycyrrhrizae radix, fructus Jujubae, radix astragali, ginseng radix, radix Angelicae sinensis and Cordyceps militaris. The invention mixes and stews the traditional Chinese medicine composition, lean meat/pork rib and water for 30-60 minutes, turns off fire and adds 4-8 g of salt for seasoning to obtain the nutritional medicated diet. The invention prepares the medical-edible traditional Chinese medicinal materials into the nutrition bag with medical value, contains rich vitamins and minerals, can tonify qi and nourish blood, invigorate spleen and promote the production of body fluid, invigorate spleen and nourish face, and has very important effects on human health care. And the soup cooked without adding any seasoning can be meat and cocoa, thin but not light, thick but not greasy.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicine processing, and particularly relates to a traditional Chinese medicine composition, a preparation method and application thereof, and a nutritional medicated diet and a preparation method thereof.
Background
The modern society has fast life rhythm and great working pressure, and people are often in a sub-health state, so that people are easy to attack by diseases. In addition, the overload of mental and physical labor of modern society causes frequent stay up, aggravates the consumption of organism, so general physical weakness, deficiency of qi and blood, malnutrition, inappetence, mental retardation, fatigue and weakness etc. are manifested.
People often take medicines to achieve the effect of relieving bad performances, but the medicines can produce side effects on human bodies on one hand, and on the other hand, the medicines can only be taken for a short period, so that the curative effect can be rapidly produced in a short period, and the long-term conditioning and recovery of the bodies are not facilitated. Therefore, a traditional Chinese medicine composition and a medicated diet are required to be developed, and the effects of health care are achieved by combining food materials and traditional Chinese medicines.
Disclosure of Invention
In view of the above, the invention aims to provide a traditional Chinese medicine composition, a preparation method and application thereof, and a nutritional medicated diet and a preparation method thereof, which overcome the problems of inconvenient conditioning of medicines and easy generation of side effects of medicines.
In order to achieve the above object, the present invention provides the following technical solutions:
The invention provides a traditional Chinese medicine composition which comprises the following raw materials in parts by weight: 10-15 parts of morchella, 1-5 parts of Chinese date, 3-5 parts of medlar, 2-5 parts of gorgon euryale seed, 6-8 parts of yam, 5-10 parts of lotus seed, 3-6 parts of emblic leafflower fruit, 5-8 parts of dried orange peel and 12-15 parts of poria cocos;
or 10 to 15 parts of morchella, 12 to 18 parts of liquorice, 1 to 5 parts of Chinese date, 15 to 25 parts of astragalus, 5 to 10 parts of ginseng, 4 to 6 parts of angelica and 5 to 10 parts of cordyceps militaris.
The invention also provides a preparation method of the traditional Chinese medicine composition, which comprises the following steps:
1) Superfine pulverizing the raw materials to 50-70 meshes, mixing with water 5-20 times of the weight of the raw materials, decocting for 2-3 times, and filtering to obtain decoction and medicinal residues;
2) Mixing and fermenting the filtered residues, water accounting for 4-7 times of the weight of the raw materials, sucrose accounting for 9-11% of the weight of the raw materials and lactobacillus, and centrifugally filtering to obtain a fermentation extract;
3) Mixing the decoction and the fermentation extract, and spray drying to obtain the Chinese medicinal composition.
Preferably, the temperature of the decoction in the step 1) is 80-100 ℃, and the time of the decoction is 20-40 min.
Preferably, the inoculation amount of the lactobacillus in the step 2) is 5×10 6～6×106 CFU/mL.
Preferably, the temperature of the fermentation is 40-42 ℃, and the fermentation time is 1-3 days.
Preferably, the air inlet temperature of the spray drying is 150-170 ℃, and the air outlet temperature is 90-110 ℃.
The invention also provides the application of the traditional Chinese medicine composition prepared by the preparation method in preparing medicines for tonifying qi and nourishing blood/strengthening spleen and beautifying.
The invention also provides a nutritional medicated diet, which comprises the traditional Chinese medicine composition and the traditional Chinese medicine composition prepared by the preparation method.
The invention also provides a preparation method of the nutritional medicated diet, which is characterized by comprising the following steps of:
the traditional Chinese medicine composition, the traditional Chinese medicine composition prepared by the preparation method, lean meat/pork rib and water are mixed and stewed for 30-60 minutes, and 4-8 g of salt is added for seasoning after fire is turned off.
Preferably, the mass-volume ratio of the traditional Chinese medicine composition to lean meat/spareribs to water is 30-40 g: 450-550 g: 800-1000 mL.
Compared with the prior art, the invention has the following beneficial effects:
According to the invention, the Morchella esculenta, the Chinese date, the medlar, the gorgon euryale seed, the Chinese yam, the lotus seed, the phyllanthus emblica, the dried orange peel and the poria cocos are mutually compatible, and the synergistic cooperation has the effects of strengthening spleen and nourishing face, clearing fire and reducing dryness and promoting urination, and is used for sub-health people with emaciation, long-term malnutrition, high pressure and people with dull complexion, insomnia and long spots and endocrine disturbance. The morchella, the liquorice, the Chinese date, the astragalus, the ginseng, the Chinese angelica and the cordyceps militaris are mutually compatible, and the synergistic combination has the effects of tonifying qi and nourishing blood, strengthening spleen and promoting the production of body fluid, is suitable for people with deficiency of both qi and blood, and can be used for relieving symptoms such as qi deficiency, blood deficiency or qi-blood deficiency caused by sweating, vomiting, diarrhea or chronic diseases.
The edible materials are commonly used, medicinal and edible traditional Chinese medicinal materials are added, and the mushrooms with medicinal value are prepared into nutrition packages, so that the nutrition packages contain abundant vitamins and minerals, can tonify qi and nourish blood, invigorate spleen and promote salivation, invigorate spleen and nourish face, and have important effects on human health. And the soup cooked without adding any seasoning can be meat and cocoa, thin but not light, thick but not greasy.
According to the invention, the granularity of the medicinal material reaches the cell disruption level through superfine grinding, so that the active ingredients among cells and in cells of the medicinal material are directly released, and the dissolution speed and dissolution rate of the active ingredients in the medicinal material are improved; the active ingredients in the medicinal residues can be reused through the fermentation of the medicinal residues, so that the bitter taste of the traditional Chinese medicine and the heavy metal and pesticide residues are reduced, the release and the dissolution of the active ingredients in the stewing process of the traditional Chinese medicine steamed stuffed bun are facilitated, and the nutrition and the taste of the medicated diet are ensured.
Detailed Description
The invention provides a traditional Chinese medicine composition which comprises the following raw materials in parts by weight: 10-15 parts of morchella, 1-5 parts of Chinese date, 3-5 parts of medlar, 2-5 parts of gorgon euryale seed, 6-8 parts of yam, 5-10 parts of lotus seed, 3-6 parts of emblic leafflower fruit, 5-8 parts of dried orange peel and 12-15 parts of poria cocos;
In the invention, the dosage of the morchella is preferably 12-14 parts; morchella esculenta is sweet and flat; spleen and stomach meridian; has stomach regulating and digestion promoting effects; regulating qi-flowing and eliminating phlegm; primary dyspepsia; cough with excessive phlegm;
The dosage of the jujube is preferably 2-4 parts; jujube is sweet and warm; spleen and stomach meridian; has effects in invigorating spleen and stomach, invigorating qi and blood, tranquilizing mind, regulating nutrient and defensive qi, and regulating drug properties; is mainly used for treating weakness of spleen and stomach, deficiency of qi and blood, anorexia, loose stool, listlessness, debilitation, palpitation and insomnia; the women are dysphoria and incoordination between ying and wei;
The dosage of the medlar is preferably 4 parts; the medlar is neutral and sweet; has effects in nourishing liver and kidney, and improving eyesight; can be used for treating asthenia, soreness of waist and knees, dizziness, tinnitus, internal heat, diabetes, blood deficiency, sallow complexion, and blurred vision;
the dosage of the gorgon fruit is preferably 3-4 parts; gordon euryale seed is sweet, astringent and flat in taste; spleen and kidney meridian entered; has effects in invigorating kidney, stopping nocturnal emission, invigorating spleen, relieving diarrhea, eliminating dampness, and stopping leukorrhagia; is used for treating nocturnal emission, enuresis, frequent urination, spleen deficiency, chronic diarrhea, turbid urine, leukorrhagia;
the dosage of the yam is preferably 7 parts; the yam is sweet and flat; spleen, lung and kidney meridians; has effects in invigorating spleen, nourishing stomach, promoting salivation, tonifying lung, invigorating kidney, and astringing essence; can be used for treating spleen deficiency, anorexia, chronic diarrhea, lung deficiency, asthma, cough, kidney deficiency, spermatorrhea, leukorrhagia, frequent urination, and deficiency heat diabetes;
The dosage of lotus seeds is preferably 6-9 parts; lotus seed taste is sweet and astringent; has effects in invigorating spleen, relieving diarrhea, nourishing heart, and invigorating kidney;
The dosage of the phyllanthus emblica is preferably 4-5 parts; emblic leafflower fruit is bitter, sweet, sour and cool in nature; has effects in clearing heat and relieving sore throat; moistening lung and resolving phlegm; promoting salivation and quenching thirst;
The consumption of the dried orange peel is preferably 13-17 parts; the dried orange peel is pungent and bitter and warm; spleen and lung meridian entered; has the effects of regulating qi-flowing, invigorating spleen, eliminating dampness and resolving phlegm;
The dosage of the poria cocos is preferably 13-14 parts; poria cocos is sweet and flat; warm nature and bland taste; has effects in removing dampness, promoting diuresis, invigorating spleen, regulating stomach function, and tranquilizing mind; mainly treats difficult urination, edema and fullness, phlegm-fluid retention, cough and vomiting, diarrhea, spermatorrhea, stranguria with turbid urine, palpitation and amnesia;
or 10 to 15 parts of morchella, 12 to 18 parts of liquorice, 1 to 5 parts of Chinese date, 15 to 25 parts of astragalus, 5 to 10 parts of ginseng, 4 to 6 parts of angelica and 5 to 10 parts of cordyceps militaris.
In the invention, the dosage of the morchella is preferably 12-14 parts; morchella esculenta is sweet and flat; spleen and stomach meridian; has stomach regulating and digestion promoting effects; regulating qi-flowing and eliminating phlegm; primary dyspepsia; cough with excessive phlegm;
The dosage of the liquorice is preferably 6-7 parts; licorice is sweet and flat; return to heart, lung, spleen and stomach meridians; has effects in invigorating spleen, replenishing qi, clearing away heat and toxic materials, eliminating phlegm, relieving cough, relieving spasm, relieving pain, and regulating the functions of the above materials; can be used for treating weakness of spleen and stomach, listlessness, debilitation, palpitation, short breath, cough with excessive phlegm, abdominal pain, limb spasm, carbuncle, swelling, sore and toxic materials, and relieving drug toxicity and intensity;
The dosage of the jujube is preferably 2-4 parts; jujube is sweet and warm; spleen and stomach meridian; has effects in invigorating spleen and stomach, invigorating qi and blood, tranquilizing mind, regulating nutrient and defensive qi, and regulating drug properties; is mainly used for treating weakness of spleen and stomach, deficiency of qi and blood, anorexia, loose stool, listlessness, debilitation, palpitation and insomnia; the women are dysphoria and incoordination between ying and wei;
The dosage of the astragalus is preferably 18-22 parts; astragalus root is warm in nature and sweet in taste; has effects in invigorating qi, consolidating superficial resistance, removing toxic substances, expelling pus, promoting urination, and promoting granulation;
The dosage of the ginseng is preferably 6-9 parts; ginseng is used for treating fatigue and deficiency, anorexia, listlessness, regurgitation and vomiting of food, stool smooth stool, deficiency cough and dyspnea, spontaneous perspiration and sudden collapse, palpitation, amnesia, dizziness and headache, impotence, frequent urination, diabetes, metrorrhagia and metrostaxis of women, chronic infantile convulsion, and deficiency of all qi, blood and body fluids;
The dosage of the angelica is preferably 5 parts; angelica is sweet, pungent and bitter; sex temperature; liver, heart and spleen channels; has effects in replenishing blood, promoting blood circulation, regulating menstruation, relieving pain, moistening dryness, and smoothing intestine; syndrome of main blood deficiency, menoxenia, amenorrhea, dysmenorrhea, abdominal mass accumulation, metrorrhagia, cold and abdominal pain, flaccidity arthralgia, skin numbness, intestinal dryness and constipation, red dysentery with severe back weight, carbuncle, sore and ulcer, traumatic injury;
the dosage of the cordyceps militaris is preferably 6-9 parts; cordyceps militaris stroma can be used as medicine, has mild taste, can nourish lung and kidney, stop bleeding and resolve phlegm, and can be used for treating pulmonary tuberculosis, senile weakness, anemia and weakness, etc.
The invention also provides a preparation method of the traditional Chinese medicine composition, which comprises the following steps:
1) Superfine pulverizing the raw materials to 50-70 meshes, mixing with water 5-20 times of the weight of the raw materials, decocting for 2-3 times, and filtering to obtain decoction and medicinal residues;
2) Mixing and fermenting the filtered residues, water accounting for 4-7 times of the weight of the raw materials, sucrose accounting for 9-11% of the weight of the raw materials and lactobacillus, and centrifugally filtering to obtain a fermentation extract;
3) Mixing the decoction and the fermentation extract, and spray drying to obtain the Chinese medicinal composition.
In the invention, the raw materials are crushed into 50 to 70 meshes in an ultrafine way, mixed with water which is 5 to 20 times of the weight of the raw materials and decocted for 2 to 3 times, and filtered to obtain decoction and dregs; the mesh number after crushing is preferably 55-65 meshes; the water is preferably used in an amount of 8 to 17 times the weight of the raw materials; the temperature of the decoction is preferably 80-100 ℃, and more preferably 85-95 ℃; the time for the decoction is preferably 20 to 40min, more preferably 25 to 35min.
In the invention, the filtered dregs, water with the weight 4-7 times of the weight of the raw materials, sucrose with the weight 9-11% of the weight of the raw materials and lactobacillus are mixed and fermented, and the fermentation extract is obtained by centrifugal filtration; the water is preferably used in an amount of 5 to 6 times the weight of the raw materials; the consumption of the sucrose is preferably 9.5-10.5% of the weight of the raw materials; the inoculation amount of the lactobacillus is preferably 5 multiplied by 10 6～6×106 CFU/mL; further preferably 5.2X10 6～5.8×106 CFU/mL; the fermentation temperature is preferably 40-42 ℃, and more preferably 41 ℃; the fermentation time is preferably 1 to 3 days, more preferably 1.5 to 2.5 days.
In the invention, the decoction and the fermentation extract are mixed and spray-dried to obtain a traditional Chinese medicine composition; the inlet air temperature of the spray drying is preferably 150-170 ℃, and more preferably 155-165 ℃; the outlet air temperature is preferably 90 to 110 ℃, and more preferably 95 to 105 ℃.
The invention also provides the application of the traditional Chinese medicine composition prepared by the preparation method in preparing medicines for tonifying qi and nourishing blood/strengthening spleen and beautifying.
The invention also provides a nutritional medicated diet, which comprises the traditional Chinese medicine composition and the traditional Chinese medicine composition prepared by the preparation method.
The invention also provides a preparation method of the nutritional medicated diet, which comprises the following steps:
the traditional Chinese medicine composition, the traditional Chinese medicine composition prepared by the preparation method, lean meat/pork rib and water are mixed and stewed for 30-60 minutes, and 4-8 g of salt is added for seasoning after fire is turned off.
In the invention, the mass-volume ratio of the traditional Chinese medicine composition, lean meat/spareribs and water is preferably 30-40 g: 450-550 g: 800-1000 mL; further preferably 32 to 38g: 480-520 g: 850-950 mL; the stewing time is preferably 35-55 min; the salt is preferably used in an amount of 5 to 7g.
The technical solutions provided by the present invention are described in detail below with reference to examples, but they should not be construed as limiting the scope of the present invention.
Example 1
The invention provides a traditional Chinese medicine composition which comprises the following raw materials in parts by weight: 13 parts of morchella, 3 parts of Chinese date, 4 parts of medlar, 4 parts of gorgon fruit, 7 parts of yam, 8 parts of lotus seed, 5 parts of emblic leafflower fruit, 6 parts of dried orange peel and 13 parts of poria cocos.
Superfine pulverizing the raw materials to 60 mesh, mixing with 15 times of water, decocting at 90deg.C for 3 times each for 30min, and filtering to obtain decoction and residue; mixing and fermenting the filtered residues, water accounting for 5 times of the weight of the raw materials, sucrose accounting for 10% of the weight of the raw materials and lactobacillus, and centrifugally filtering the lactobacillus with the inoculation amount of 5.5X10 6 CFU/mL to obtain a fermentation extract; mixing the decoction and the fermentation extract, and spray drying (inlet air temperature is 160deg.C, outlet air temperature is 100deg.C preferably) to obtain Chinese medicinal composition (A).
And (3) mixing 35g of the traditional Chinese medicine composition, 500g of pork rib and 900mL of water, stewing for 60 minutes, and adding 6g of salt for seasoning to obtain the nutritional medicated diet (D).
Example 2
The invention provides a traditional Chinese medicine composition which comprises the following raw materials in parts by weight: 10 parts of morchella, 1 part of Chinese date, 3 parts of medlar, 2 parts of gorgon fruit, 6 parts of yam, 5 parts of lotus seed, 3 parts of emblic leafflower fruit, 5 parts of dried orange peel and 12 parts of poria cocos.
Pulverizing the raw materials into 50 mesh, mixing with water 5 times the weight of the raw materials, decocting at 80deg.C for 2 times each for 20min, and filtering to obtain decoction and residue; mixing and fermenting the filtered residues, water 4 times of the weight of the raw materials, sucrose 9% of the weight of the raw materials and lactobacillus, and centrifugally filtering the lactobacillus with the inoculation amount of 5X 10 6 CFU/mL to obtain a fermentation extract; mixing the decoction and the fermentation extract, and spray drying (inlet air temperature 150 deg.C; outlet air temperature preferably 90 deg.C) to obtain the final product.
And (3) mixing 30g of the traditional Chinese medicine composition, 450g of lean meat and 800mL of water, stewing for 30 minutes, and adding 4g of salt for seasoning to obtain the nutritional medicated diet (E).
Example 3
The invention provides a traditional Chinese medicine composition which comprises the following raw materials in parts by weight: 15 parts of morchella, 5 parts of Chinese date, 5 parts of medlar, 5 parts of gorgon fruit, 8 parts of yam, 10 parts of lotus seed, 6 parts of emblic leafflower fruit, 8 parts of dried orange peel and 15 parts of poria cocos.
Superfine pulverizing the raw materials to 70 mesh, mixing with water 20 times the weight of the raw materials, decocting at 100deg.C for 3 times, 40min each time, and filtering to obtain decoction and residue; mixing and fermenting the filtered residues, water with the weight being 7 times of that of the raw materials, sucrose with the weight being 11% of that of the raw materials and lactobacillus, and centrifugally filtering the mixture with the inoculation amount of the lactobacillus of 6 multiplied by 10 6 CFU/mL to obtain a fermentation extract; mixing the decoction and the fermentation extract, and spray drying (inlet air temperature of 170deg.C and outlet air temperature of 110deg.C) to obtain Chinese medicinal composition (C).
40G of the traditional Chinese medicine composition, 550g of pork ribs and 1000mL of water are mixed and stewed for 60 minutes, and 8g of salt is added for seasoning to obtain the nutritional medicated diet (F).
Example 4
The invention provides a traditional Chinese medicine composition which comprises the following raw materials in parts by weight: 13 parts of morchella, 15 parts of liquorice, 3 parts of Chinese date, 20 parts of astragalus, 8 parts of ginseng, 5 parts of angelica and 8 parts of cordyceps militaris.
Superfine pulverizing the raw materials to 60 mesh, mixing with 15 times of water, decocting at 90deg.C for 3 times each for 30min, and filtering to obtain decoction and residue; mixing and fermenting the filtered residues, water accounting for 5 times of the weight of the raw materials, sucrose accounting for 10% of the weight of the raw materials and lactobacillus, and centrifugally filtering the lactobacillus with the inoculation amount of 5.5X10 6 CFU/mL to obtain a fermentation extract; mixing the decoction and the fermentation extract, and spray drying (inlet air temperature 160 deg.C; outlet air temperature preferably 100deg.C) to obtain the final product.
And (3) mixing 35g of the traditional Chinese medicine composition, 500g of pork rib and 900mL of water, stewing for 60 minutes, and adding 6g of salt for seasoning to obtain the nutritional medicated diet (J).
Example 5
The invention provides a traditional Chinese medicine composition which comprises the following raw materials in parts by weight of 10 parts of Morchella esculenta, 12 parts of Glycyrrhrizae radix, 1 part of fructus Jujubae, 15 parts of radix astragali, 5 parts of Ginseng radix, 4 parts of radix Angelicae sinensis and 5 parts of Cordyceps militaris.
Pulverizing the raw materials into 50 mesh, mixing with water 5 times the weight of the raw materials, decocting at 80deg.C for 2 times each for 20min, and filtering to obtain decoction and residue; mixing and fermenting the filtered residues, water 4 times of the weight of the raw materials, sucrose 9% of the weight of the raw materials and lactobacillus, and centrifugally filtering the lactobacillus with the inoculation amount of 5X 10 6 CFU/mL to obtain a fermentation extract; mixing the decoction and the fermentation extract, and spray drying (inlet air temperature 150 deg.C; outlet air temperature preferably 90 deg.C) to obtain the final product.
And (3) mixing 30g of the traditional Chinese medicine composition, 450g of lean meat and 800mL of water, stewing for 30 minutes, and adding 4g of salt for seasoning to obtain the nutritional medicated diet (K).
Example 6
The invention provides a traditional Chinese medicine composition which comprises the following raw materials in parts by weight: 15 parts of morchella, 18 parts of liquorice, 5 parts of Chinese date, 25 parts of astragalus, 10 parts of ginseng, 6 parts of angelica and 10 parts of cordyceps militaris.
Superfine pulverizing the raw materials to 70 mesh, mixing with water 20 times the weight of the raw materials, decocting at 100deg.C for 3 times, 40min each time, and filtering to obtain decoction and residue; mixing and fermenting the filtered residues, water with the weight being 7 times of that of the raw materials, sucrose with the weight being 11% of that of the raw materials and lactobacillus, and centrifugally filtering the mixture with the inoculation amount of the lactobacillus of 6 multiplied by 10 6 CFU/mL to obtain a fermentation extract; mixing the decoction and the fermentation extract, and spray drying (inlet air temperature of 170deg.C and outlet air temperature of 110deg.C) to obtain Chinese medicinal composition (I).
40G of the traditional Chinese medicine composition, 550g of pork ribs and 1000mL of water are mixed and stewed for 60 minutes, and 8g of salt is added for seasoning to obtain the nutritional medicated diet (L).
Experimental example 1
Selecting 140 volunteers with poor gastrointestinal functions, poor sleep quality and poor face condition of 140 volunteers, respectively dividing the volunteers into 7 groups of 20 persons, and respectively taking the traditional Chinese medicine compositions (A-C) and nutritional medicated diet (D-F) prepared in the examples 1-3 in the experimental groups; the Chinese medicinal composition is orally taken for 1 time each day after breakfast and supper, and 5g each time; the nutritional medicated diet is administered for 21 days every 1 dose, and soup is drunk to eat meat; the control group takes soup prepared by decocting 20g of poria cocos, 20g of Huaishan, 20g of lotus seeds, 20g of semen euryales and 1000mL of water, and 1 dose every other day. The efficacy and safety were evaluated after 21 days.
1. Efficacy test:
Effects on gastrointestinal function: the continuous administration of the product is effective in feeling the gastrointestinal function more general or the appetite is enhanced, and is ineffective in feeling the gastrointestinal function and appetite are not affected.
Effect on sleep: the sleep is obviously improved to be effective after the products are continuously taken, and the sleep is not affected to be effective.
Effect on the surface appearance: the feeling of the product is more sufficient than before the experiment, the face is ruddy, and the feeling of the product is ineffective without greatly influencing the state of spirit and the face.
Experimental results: as shown in table 1, it is clear from table 1 that the traditional Chinese medicine composition and the medicated diet of the present invention have remarkable effects of improving and relieving symptoms such as gastrointestinal dyspepsia, listlessness, and the like, and can feel that the intestines and stomach are clear, the appetite is enhanced, the sleep is better after taking, and then the effects of sufficient spirit, ruddy face, difficult fatigue, etc. are better compared with the traditional four-spirit Shang Jianpi for maintaining the looks, adjusting malnutrition, dull complexion, insomnia, etc.
TABLE 1 Effect of different treatment groups on the effects of invigorating spleen and caring skin
2. Safety evaluation:
Stage 1: safety and no adverse reaction.
2 Stages: is safer, has adverse reaction, and can be continuously administered without any treatment.
3 Stages: has safety problem and moderate adverse reaction, and can be continuously administered after treatment.
4 Stages: the test was discontinued due to adverse reactions.
Experimental results: in the experimental process, no adverse reaction is found, and the safety is good.
Experimental example 2
Animal experiment:
The model preparation is prepared by orally and intragastrically administering a model preparation compound diphenoxylate, establishing a constipation model of the mice, and measuring the first-grain black stool defecation time, the defecation grain number and the defecation weight of the mice within 5 or 6 hours to reflect the defecation condition of the model mice.
Adult male mice were selected and weighing 18-22g, and were divided into 5 groups of 10 animals each. Surgical scissors, ophthalmic forceps, ruler, syringe, balance, activated carbon powder, gum arabic and compound diphenoxylate.
Preparing ink: accurately weighing 100g of gum arabic, adding 800mL of water, boiling until the solution is transparent, weighing 50g of activated carbon (powder) and adding into the solution, boiling for three times, cooling the solution, adding water to 1000mL, keeping the volume at 4 ℃ in a refrigerator, and shaking uniformly before use.
Preparing a compound diphenoxylate suspension: compound diphenoxylate tablet, each tablet contains 2.5mg of compound diphenoxylate. Taking a corresponding amount of compound diphenoxylate tablets, grinding the tablets into powder by a mortar, adding water to 100mL, and preparing the tablets before use.
Dose grouping and time of sample administration: model mice were randomly divided into three high, medium and low dose groups, a blank control group and a model control group. The traditional Chinese medicine composition prepared in the example 1 is given to 2.5 times of human clinical dose in a low dose group, the traditional Chinese medicine composition prepared in the example 1 is given to 5 times of human clinical dose in a medium dose group, and the traditional Chinese medicine composition prepared in the example 1 is given to 10 times of human clinical dose in a high dose group. The administration was continued for 7 days.
The experimental method comprises the following steps: animals in each group were given a 7 day period of time without water withdrawal and no water withdrawal, and the model control group and three dose groups were given a suspension of diphenoxylate (7.5 mg/kg BW) by gavage, and the blank control group was given water gavage. After 0.5 hours, each of the dosing groups was given an ink (5% active carbon powder, 10% gum arabic) with the corresponding test sample, respectively, and the negative and model control groups were given an ink lavage. The black discharge time, number of black discharge particles in 5 or 6 hours and weight of each animal were recorded from the start of ink filling.
Experimental results: as shown in table 2, compared with the model group, the first granule defecation time of each dosage group and the positive control group of the traditional Chinese medicine composition prepared by the invention is obviously shortened, the defecation number is obviously increased, and the gastrointestinal condition can be effectively improved.
Effect of table 2 composition on constipation model mice defecation
| Group of | First granule defecation time/min | Number of bowel movement grains for 3 hours | Number of defecation grains for 6 hours |
| Blank group | 130.28±7.46 | 10.01±2.03 | 10.43±2.14 |
| Model group | 268.43±18.13 | 3.01±0.12 | 5.21±1.34 |
| High dose group | 121.87±2.01 | 8.31±0.96 | 10.18±1.90 |
| Medium dose group | 135.34±2.08 | 4.96±0.32 | 8.97±0.99 |
| Low dose group | 140.32±4.19 | 3.89±0.34 | 5.86±0.76 |
Experimental example 3
Volunteers 140 with symptoms of pale complexion or sallow complexion, dizziness, lassitude of limbs, shortness of breath, lazy speaking, palpitation, diet reduction, pale tongue with thin white coating, weak pulse or weak and powerful and the like are selected, wherein 120 people in the treatment group are equally divided into 6 groups, and 20 people in each group. Control group 20.
Volunteers were grouped and observed using an open, randomized, control method. The treatment group takes the traditional Chinese medicine compositions (G-I) and the nutritional medicated diet (J-L) prepared in the examples 4-6, and the traditional Chinese medicine compositions are orally taken for 1 time each time after breakfast and supper and 5G each time; the nutritional medicated diet is administered by 1 dose every day, and the soup is drunk to eat meat. The control group took eight precious granules (3.5 g x 20 bags/box, national drug standard Z51022270, manufactured by the company of the sunshine pharmaceutical Co., ltd.). 1 bag at a time, and is taken after breakfast and supper by adding warm boiled water. The treatment course is 14 days, and the curative effect and the safety are evaluated after 1 treatment course.
1. Efficacy test:
The effect is shown: the symptoms and signs are obviously improved within 14 days of administration. The integral value of syndrome is reduced by more than or equal to 70 percent.
The method is effective: symptoms and signs are all improved within 14 days of administration. The integral value of syndrome is reduced by more than or equal to 30 percent.
Invalidation: symptoms and signs were not significantly improved or even aggravated within 14 days of administration. The integral reduction value of syndrome is less than 30%.
Note that: the calculation formula (nimodipine method) is: [ (pre-treatment integral-post-treatment integral)/(pre-treatment integral ] ×100%
Evaluation of syndrome curative effect:
the effect is shown: symptoms or signs decreased by 2-grade (3 to 1-grade) after treatment compared to before treatment.
The method is effective: symptoms or signs decreased 1-way (3 to 2 points, 2 to 1 point) after treatment compared to before treatment.
Invalidation: the symptoms or signs are not obviously improved after treatment compared with those before treatment, and the standard is not met.
Table 3 Chinese medical science syndrome observation and record table
Experimental results: as shown in Table 4, the Chinese medicinal composition and the medicated diet disclosed by the invention can effectively relieve symptoms such as dizziness, pale complexion, less qi and lazy speaking, listlessness and hypodynamia, palpitation and inappetence caused by deficiency of qi and blood, and have the effects of tonifying qi and nourishing blood, and strengthening spleen and promoting fluid production.
TABLE 4 influence of different treatment groups on qi and blood deficiency
2. Safety evaluation:
Stage 1: safety and no adverse reaction.
2 Stages: is safer, has adverse reaction, and can be continuously administered without any treatment.
3 Stages: has safety problem and moderate adverse reaction, and can be continuously administered after treatment.
4 Stages: the test was discontinued due to adverse reactions.
Experimental results: in the experimental process, no adverse reaction is found, and the safety is good.
According to the embodiment and experimental example, the morchella, the Chinese date, the medlar, the gorgon euryale seed, the Chinese yam, the lotus seed, the phyllanthus emblica, the dried orange peel and the poria cocos are mutually matched, and the synergistic combination has the effects of strengthening the spleen and maintaining beauty, clearing fire and reducing dryness and promoting urination, and is used for sub-health people with thin body, long-term malnutrition, high pressure, dark complexion, insomnia and long speck and people with endocrine disturbance. The morchella, the liquorice, the Chinese date, the astragalus, the ginseng, the Chinese angelica and the cordyceps militaris are mutually compatible, and the synergistic combination has the effects of tonifying qi and nourishing blood, strengthening spleen and promoting the production of body fluid, is suitable for people with deficiency of both qi and blood, and can be used for relieving symptoms such as qi deficiency, blood deficiency or qi-blood deficiency caused by sweating, vomiting, diarrhea or chronic diseases.
The foregoing is merely a preferred embodiment of the present invention and it should be noted that modifications and adaptations to those skilled in the art may be made without departing from the principles of the present invention, which are intended to be comprehended within the scope of the present invention.
Claims (10)
1. The traditional Chinese medicine composition is characterized by comprising the following raw materials in parts by weight: 10-15 parts of morchella, 1-5 parts of Chinese date, 3-5 parts of medlar, 2-5 parts of gorgon euryale seed, 6-8 parts of yam, 5-10 parts of lotus seed, 3-6 parts of emblic leafflower fruit, 5-8 parts of dried orange peel and 12-15 parts of poria cocos;
or 10 to 15 parts of morchella, 12 to 18 parts of liquorice, 1 to 5 parts of Chinese date, 15 to 25 parts of astragalus, 5 to 10 parts of ginseng, 4 to 6 parts of angelica and 5 to 10 parts of cordyceps militaris.
2. The method for preparing the traditional Chinese medicine composition as claimed in claim 1, which is characterized by comprising the following steps:
1) Superfine pulverizing the raw materials to 50-70 meshes, mixing with water 5-20 times of the weight of the raw materials, decocting for 2-3 times, and filtering to obtain decoction and medicinal residues;
2) Mixing and fermenting the filtered residues, water accounting for 4-7 times of the weight of the raw materials, sucrose accounting for 9-11% of the weight of the raw materials and lactobacillus, and centrifugally filtering to obtain a fermentation extract;
3) Mixing the decoction and the fermentation extract, and spray drying to obtain the Chinese medicinal composition.
3. The method for preparing a Chinese medicinal composition according to claim 2, wherein the temperature of the decoction in the step 1) is 80-100 ℃, and the time of the decoction is 20-40 min.
4. The method for preparing a Chinese medicinal composition according to claim 2, wherein the inoculation amount of the lactobacillus in the step 2) is 5×10 6～6×106 CFU/mL.
5. The method for preparing a Chinese medicinal composition according to claim 2, wherein the fermentation temperature is 40-42 ℃ and the fermentation time is 1-3 days.
6. The method for preparing a Chinese medicinal composition according to claim 2, wherein the spray-drying air inlet temperature is 150-170 ℃ and the air outlet temperature is 90-110 ℃.
7. The application of the traditional Chinese medicine composition prepared by the preparation method of any one of claims 2 to 6 in preparing medicines for tonifying qi and nourishing blood/strengthening spleen and beautifying.
8. A nutritional medicated diet characterized by comprising the traditional Chinese medicine composition according to claim 1 and the traditional Chinese medicine composition prepared by the preparation method according to any one of claims 2-6.
9. The method for preparing the nutritional medicated diet according to claim 8, comprising the following steps:
The traditional Chinese medicine composition prepared by the preparation method of any one of claims 2 to 6 and the traditional Chinese medicine composition of claim 1, lean meat/spareribs and water are mixed and stewed for 30 to 60 minutes, and 4 to 8g of salt is added for seasoning after fire is turned off.
10. The method for preparing a nutritional medicated diet according to claim 9, wherein the mass-to-volume ratio of the traditional Chinese medicine composition, lean meat/spareribs and water is 30-40 g: 450-550 g: 800-1000 mL.
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN118286338A true CN118286338A (en) | 2024-07-05 |
Family
ID=
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103520577A (en) | Medicine-and-food dual-purpose preparation for treating pneumoconiosis, clearing away lung-heat and nourishing heart and preparation method for medicine-and-food dual-purpose preparation | |
| CN103127433B (en) | Chinese medicament for treating lung cancer and preparation method thereof | |
| CN105920514A (en) | Traditional Chinese medicinal composition for treating metabolic syndrome | |
| CN105816788A (en) | Traditional Chinese medicine preparation for treating infantile dyspepsia and preparation method thereof | |
| CN107865181A (en) | Chinese medicine ferment pressed candy and preparation method thereof | |
| CN105852084A (en) | Functional food composition capable of reducing weight and reducing blood lipid and preparation method of functional food composition | |
| CN104940645A (en) | Dendrobium officinale traditional Chinese medicine composition with functions of maintaining beauty and keeping young and preparation of dendrobium officinale traditional Chinese medicine composition | |
| CN106509576A (en) | Powder medicinal granules having efficacy of promoting digestion and preparation method of powder medicinal granules | |
| CN109528966B (en) | Health wine and preparation method thereof | |
| KR20160000695A (en) | Herbal-medicine containing dha for recovering fatigue and enhancing memory, and method of manufacturing the same | |
| CN103816440A (en) | Acne removing composition prepared from medicinal materials with homology of medicine and food | |
| CN106511705A (en) | Traditional Chinese medicine preparation for treating and regulating blood fat and reducing blood pressure and blood sugar and preparation method | |
| CN113785948A (en) | Solid beverage capable of benefiting qi, promoting production of body fluid and relaxing bowel and preparation method thereof | |
| CN102961621A (en) | Traditional Chinese medicine preparation for treating viral cardiac neurosis | |
| CN118286338A (en) | Traditional Chinese medicine composition, preparation method and application thereof, and nutritional medicated diet and preparation method | |
| CN112891436A (en) | Preparation for promoting circulation in organism and preparation method thereof | |
| CN105079391A (en) | Effervescent tablets for preventing oral ulcer and preparation method therefor | |
| CN1044198C (en) | Prescription of weifuyuan capsule and its preparation method | |
| CN116251152B (en) | Traditional Chinese medicine composition for growing and blackening hair, preparation method and application of traditional Chinese medicine preparation | |
| CN106038994A (en) | Food medicine for assisting in blood glucose reducing and preparation method thereof | |
| CN105596998A (en) | Traditional Chinese medicine preparation for alternant overeat and anorexia and preparation method thereof | |
| CN106047617A (en) | Health-care rice wine prepared from American ginseng | |
| CN105434933A (en) | Traditional Chinese medicine pill used for treating hot sweat symptom, and preparation method thereof | |
| CN105232975A (en) | Preparation for improving symptoms of night sweat and preparation method of preparation | |
| CN106668494A (en) | Hui nationality traditional Chinese medicine astragalus membranaceus root stomach cancer-dispersing granules and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication |