CN1181867C - Chinese medicine prepn for treating varicose vein - Google Patents

Chinese medicine prepn for treating varicose vein Download PDF

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CN1181867C
CN1181867C CNB021352933A CN02135293A CN1181867C CN 1181867 C CN1181867 C CN 1181867C CN B021352933 A CNB021352933 A CN B021352933A CN 02135293 A CN02135293 A CN 02135293A CN 1181867 C CN1181867 C CN 1181867C
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radix
chinese medicine
rhizoma
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medicine preparation
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CN1398624A (en
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李正武
李强
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Abstract

The present invention discloses a Chinese medicine preparation for treating varicose varicosity, which relates to a medicine using traditional Chinese medicines as raw materials. The traditional Chinese medicines of angelica, corydalis tuber, safflower, earth worms, red sage roots, paojiazhu, atractylodes rhizomes, phellodendron bark, coix, talcum, honeysuckle stems, arnebia roots, etc. are used as the raw materials, and are processed by the processing steps of pulverization, processing, soaking, decoction, filtration, concentration, extraction, mixture, porphyrization, etc. according to medicinal properties, and medicinal powder is made. The present invention has peculiar formulation, and the present invention which is clinically observed has high curative ratio.

Description

The cirsoid Chinese medicine preparation of a kind of treatment
Affiliated technical field
The present invention relates to the cirsoid medicine of a kind of treatment, is to be the Chinese medicine preparation of raw material with Chinese medicine specifically.
Background technology
Motherland's medical science thinks that the varicosis cause of disease has following 2 points:
1, congenital wall of vein or valve weakness.This kind situation makes wall of vein be easy to expansion, and the valve of near-end produces inadequacy, makes backflow of blood.Backflow of blood has just destroyed the far-end valve gradually, produces varicosis finally, and this is a performance of whole body connective tissue weakness, so the patient often has diseases such as hemorrhoid, hernia simultaneously, and family history is often arranged.
2, occupational factor.The general person that often do not stand often has varicose veins of the lower extremity in various degree, especially to be engaged in labourer that lasting heavy burden stands for seeing more.Owing to often take orthostatic body position, movable less, the chance that lower limb muscles shrinks reduces, and influence venous blood and refluxes, and makes increased pressure, venectasia in the veins of lower extremity, and valve also thereby produce inadequacy, formation varicosis.In addition, intraperitoneal swell thing, gravid uterus etc. are because the Intraabdominal vein of compressing also can make the formation of varicose veins of the lower extremity.
Treatment varicosis adopts operative therapy more at present, promptly strips off art as veins of lower extremity.If operation can not all be stripped off the vein of varicose, the intravenous of the varicose that stays can injection of sclerosing agent, makes wall of vein produce aseptic inflammation, wall is adhered mutually, no longer varicose.Through clinical practice for many years, also can recur after many patient's operations, uncertain therapeutic efficacy is cut, and repeatedly operation also fails to cure.Modus operandi not only has certain misery to patient, and expense is higher, and cure rate is very low.Pharmacotherapy does not also have the preferable medicine of effect at present, for the traditional Chinese medical science, how to control with heat clearing and damp drying in the past, and the treatment of ignored removing heat from blood, invigorate blood circulation, detoxifying, so therapeutic effect is relatively poor.
Summary of the invention
The object of the present invention is to provide the cirsoid Chinese medicine preparation of a kind of treatment, have the very significant advantage of therapeutic effect.
Technical scheme of the present invention is based on the Chinese medicine and pharmacy theory, puts forward in conjunction with clinical practice for many years.Motherland's theory of Chinese medical science is thought: have only damp and hot and make a bet.Because the varicosis sufferer is in lower limb, and patient's root of the tongue yellow fur is thick, moistening, thus the cause of disease damp and hot really due to.Treatment is that the master also should be aided with removing heat from blood outward, invigorate blood circulation, detoxifies divided by heat clearing and damp drying, just can obtain curative effect preferably.
Proportioning raw materials of the present invention (with weight portion):
Radix Angelicae Sinensis 1-15 Rhizoma Corydalis 1-3 Flos Carthami 1-3
Pheretima 1-5 rhizoma sparganic 1-3 Radix Salviae Miltiorrhizae 1-10
Semen Persicae 1-6 Rhizoma Curcumae 1-5 Radix Clematidis 1-5
Fructus Chaenomelis 1-5 big gun Squama Manis 1-9 Radix Bupleuri 1-3
Radix Glycyrrhizae 1-9 Rhizoma Atractylodis 1-12 Cortex Phellodendri 1-12
Radix Achyranthis Bidentatae 1-15 Semen Coicis 1-30 Talcum 1-15
Caulis Akebiae 1-6 Flos Lonicerae 1-15 Radix Rehmanniae 1-15
Radix Scrophulariae 1-15 Caulis Lonicerae 1-30 Radix Arnebiae (Radix Lithospermi) 1-10
Preparing preferred weight of the present invention (part) ratio range is:
Radix Angelicae Sinensis 3-10 Rhizoma Corydalis 1.5-2.5 Flos Carthami 1.5-2.5
Pheretima 2-3 rhizoma sparganic 1.5-2.5 Radix Salviae Miltiorrhizae 3-8
Semen Persicae 1.5-2.5 Rhizoma Curcumae 2-3 Radix Clematidis 2-3
Fructus Chaenomelis 2-3 big gun Squama Manis 2-6 Radix Bupleuri 1.5-2.5
Radix Glycyrrhizae 2-6 Rhizoma Atractylodis 2-11 Cortex Phellodendri 2-11
Radix Achyranthis Bidentatae 2-13 Semen Coicis 2-28 Talcum 2-13
Caulis Akebiae 2-5 Flos Lonicerae 2-13 Radix Rehmanniae 2-13
Radix Scrophulariae 2-13 Caulis Lonicerae 2-28 Radix Arnebiae (Radix Lithospermi) 2-9
Optimum weight of the present invention (part) ratio range is:
Radix Angelicae Sinensis 5 Rhizoma Corydalis 1.7 Flos Carthamis 1.7
Pheretima 2.5 rhizoma sparganic 1.7 Radix Salviae Miltiorrhizaes 5
Semen Persicae 1.7 Rhizoma Curcumae 2.5 Radix Clematidis 2.5
Fructus Chaenomelis 2.5 big gun Squama Manis 2.5 Radix Bupleuri 1.7
Radix Glycyrrhizae 2.5 Rhizoma Atractylodis 10 Cortex Phellodendris 10
Radix Achyranthis Bidentatae 10 Semen Coiciss 26 Talcums 12
Caulis Akebiae 4 Flos Lonicerae 12 Radix Rehmanniae 12
Radix Scrophulariae 12 Caulis Loniceraes 26 Radix Arnebiae (Radix Lithospermi)s 8
The production method that above-mentioned each component is made Chinese medicine preparation of the present invention is:
1, the big gun Squama Manis is worn into coarse powder, Talcum bundle, all the other Chinese medicine fragmentations;
2, the total amount input is carried jar, and the octuple water logging that adds weight was steeped 6 hours, decocted filtration in 40 minutes, adds six times of water gagings again and decocts 30 minutes after-filtration, merges filtrate twice;
3, filtrate concentrates (contracting to 1ml by the 1g crude drug);
4, adding ethanol makes the alcohol amount of containing reach 60-70% to stir evenly, left standstill 24 hours, cross the leaching supernatant, get ethanol and reach relative density more than 1.10;
5, get above-mentioned concentrated solution and add an amount of food starch, dry in the shade, porphyrize, cross 120 mesh sieves and make powder;
6, can incapsulate the in bulk agent by every 0.5g.
The instructions of taking of Chinese medicine preparation of the present invention: three times on the one, each 1 gram is to 3 grams, and one hour ante cibum, boiled water sent down.
Chinese medicine of the present invention shows that through clinical use result following advantage is arranged:
1, because described medical material: but the Radix Angelicae Sinensis blood circulation promoting and enriching, but the Rhizoma Corydalis blood-activating and qi-promoting relieves the pain, but Flos Carthami blood circulation promoting and blood stasis dispelling, but Pheretima clearing heat for calming endogenous wind, the collateral dredging diuresis, but rhizoma sparganic removing blood stasis eliminating stagnation, but Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, but Radix Clematidis wind-damp dispelling, the meridian dredging, stopping numbness pain, but Radix Achyranthis Bidentatae blood circulation promoting and blood stasis dispelling, inducing diuresis for treating stranguria syndrome, conducting blood to flow downwards, but Fructus Chaenomelis relaxing muscles and tendons and activating QI and blood in the collateral, removing dampness to restore normal function of the stomach, but big gun Squama Manis blood circulation promoting and blood stasis dispelling, resolving the hard mass, the pain that disappears is burst dense, but Radix Bupleuri reducing fever by reconciliation, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy, but Radix Glycyrrhizae invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, emergency relieves the pain, relax the property of medicine, Rhizoma Atractylodis can be drying damp and strengthening spleen, expelling wind and removing dampness, but Cortex Phellodendri heat clearing and damp drying, eliminating fire and detoxication, reducing the asthenic fever, but Semen Coicis promoting diuresis to eliminate damp pathogen, clearing away heat and discharging pus, invigorating the spleen to arrest diarrhea, but Talcum relieving stranguria by diuresis, removing summer-heat, but Caulis Akebiae clearing away heat and promoting diuresis, but Flos Lonicerae heat-clearing and toxic substances removing, but Radix Rehmanniae clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting, but Radix Scrophulariae clearing away heat and nourishing YIN, powder detoxifcation, but Caulis Lonicerae heat-clearing and toxic substances removing, dredge the meridian passage, but Radix Arnebiae (Radix Lithospermi) removing heat from blood and promoting blood circulation, the detoxifcation rash.Therefore the present invention not only has the effect of removing damp-heat, and has the effect of relaxing muscles and tendons and activating QI and blood in the collateral, promoting blood circulation and cooling blood because rational compatibility has been given full play to the effect of the Chinese medicine of respectively distinguishing the flavor of.Be used for the treatment of varicosis, curative effect is very remarkable.
2, because the present invention be a pure Chinese medicinal preparation, each component all meets the relevant pharmaceutical control law of country and stipulates that preparation reaches the national drug sanitary standard, therefore, and to the human body nonhazardous and have no side effect.
3, because the present invention is a Chinese medicine preparation, need not decoct, so patient's taking convenience.
For showing the present invention, below provide relevant clinical observation on the therapeutic effect data to cirsoid therapeutic effect.
The present invention selects to have 100 examples of system documentation to be the object of observation from 200 clinographies of filing of Taiyuan neurosurgery specialized rehabilitation hospital, male's 49 examples wherein, and women's 51 examples, age 20-75 year, the course of disease 1 year is surplus 40 year.
Diagnostic classification:
At first the patient is carried out following two kinds of tests, to determine its symptom.
(1) coomb's test Coomb in the wrong: make the patient flat for sleeping in, will suffer from limb and raise, make blood backflow, emptying in the bent vein that expands, tourniquet is twined at 1/3 place on thigh then, and with pointing compressing small saphenous vein near-end (the only cloudy shallow group of venous that break refluxes), allows the patient stand again.If decontrol tourniquet, not loosen finger after, the vein of emptying is full of again immediately fully, this shows the great saphenous vein valvuar insufflciency; If only loosen finger, do not decontrol tourniquet, the vein of emptying also is full of immediately fully, then shows the small saphenous vein valvuar insufflciency; If neither decontrol tourniquet, also do not loosen finger, and the vein of emptying was full of in half a minute, then show shallow, organize communicans valvuar insufflciency between vein deeply.
(2), Bai Erdeshi coomb's test Coomb: allow the patient stand, push down great saphenous vein at thigh root with tourniquet, the vein of varicose is full of obviously, allows the patient firmly stretch the portion of bending knee 10-20 time then.If the vein of varicose disappears, or its full level alleviates, and also do not have the lower limb sense of expanding, and this illustrates that shallow group of venous blood is directed to dark group of intravenous, shows that also dark group of vein is unobstructed; If the degree that the vein of varicose is full of does not alleviate, or increases the weight of, the sense of lower limb distending pain is also arranged, then showing at dark group intravenous has the existence of obstruction.
According to medical history, symptom, generally sufferer is divided into: simple property varicosis, with superficial phlebitis, with three kinds of superficial vein thrombosiss.
Therapeutic Method: press preceding method three times on the one, each 1-3 gram, taking 30 continuously is a course of treatment, generally need treat 1-3 the course of treatment according to the state of an illness, can reach effect preferably.
Curative effect judging standard:
Cure: bent expanding disappears, and subjective symptoms is removed entirely.
Effectively: sx.
Therapeutic outcome:
From clinical manifestation, in the 100 routine objects of observation, simple property varicosis 24 examples are arranged, with superficial vein thrombosis 58 examples, with superficial phlebitis 18 examples.100 routine patients all produce effect after first course of therapy, effective percentage 100%.In the simple property varicosis patient of 24 examples, after first course of therapy, there are 18 examples to cure, after second course of therapy, there are 6 examples to cure cure rate 100% again.58 examples have 20 examples to cure after two course of therapy with among the superficial vein thrombosis patient, have 35 examples to cure cure rate 95% after the 3rd course of therapy again.18 examples have 6 examples to cure after two course of therapy with among the superficial phlebitis patient, have 11 examples to cure cure rate 94% after the 3rd course of therapy again.Integrate, the cure rate of the 100 routine objects of observation can reach 96%, effective percentage 100%, and statistics is listed table 1 in.As seen the present invention has very significant effect to treatment varicosis sufferer.
Table 1 therapeutic effect statistical table
The course of treatment Clinical manifestation (number) Therapeutic effect (%)
Simple property varicosis With the superficial vein thrombosis Companion's superficial phlebitis
First course of treatment Effectively 24 58 18 100%
Cure 18 18%
Second course of treatment Cure 6 20 6 50%
The 3rd course of treatment Cure 35 11 96%
Therapeutic effect Effectively 100% 100% 100% 100%
Cure 100% 95% 94% 96%
In order to prove that the present invention has the verity of significant curative effect, introduce two model cases below:
(1) Yuan Zhongjin, the man, 25 years old, No. 6 first in Sifang District Duchang road, Qingdao City, the makers-up, trouble varicosis is the several years, JIUYUE in 2000 first visit on the 1st, two lower limb severe varicosis (seeing accompanying drawing 1 photo), the scleroma that the affected part is scorching hot, have a Semen phaseoli radiati size surplus in the of 10 belongs to severe varicosis and with superficial phlebitis.Through taking Chinese medicine of the present invention, subjective symptoms alleviates after first course of treatment, and varicose disappear substantially (seeing Fig. 2 photo) is eliminated after 1/3, two course of treatment in scleroma.After the 3rd course of treatment, heal entirely.Repeatedly letter is expressed thanks.
(2) Zhang Guangqing, the man, 27 years old, do manual work in the Shiyan City, Hubei throughout the year outside, found right lower extremity varicosis before 3 years, after increase the weight of calendar year 2001 first visit on April 1 gradually: the inboard severe varicosis of right lower extremity, the affected part is scorching hot, seven, eight scleromas (seeing accompanying drawing 3 photos) are arranged, belong to the thrombotic varicosis of superficial vein.Through taking Chinese medicine of the present invention, after first course of treatment, do not ache at right lower extremity, feel to be clearly better, take after second and third course of treatment varicose disappear, heal entirely (seeing accompanying drawing 4 photos).
Description of drawings:
Fig. 1 advances first visit acropathy feelings photo at present among patient Yuan;
Fig. 2 for patient Yuan Zhongjin through taking the lower limb photo that Chinese medicine of the present invention was mailed after two courses of treatment;
Right lower extremity state of an illness photo when Fig. 3 is patient Zhang Guangqing first visit;
Fig. 4 is patient Zhang Guangqing the takes Chinese medicine of the present invention photo that right lower extremity is healed entirely after three courses of treatment.
The specific embodiment:
Embodiment 1:
Radix Angelicae Sinensis 3 Rhizoma Corydalis 1.5 Flos Carthamis 1.5
Pheretima 2 rhizoma sparganic 1.5 Radix Salviae Miltiorrhizaes 3
Semen Persicae 1.5 Rhizoma Curcumae 2 Radix Clematidis 2
Fructus Chaenomelis 2 big gun Squama Manis 2 Radix Bupleuri 1.5
Radix Glycyrrhizae 2 Rhizoma Atractylodis 2 Cortex Phellodendris 2
Radix Achyranthis Bidentatae 2 Semen Coiciss 2 Talcums 2
Caulis Akebiae 2 Flos Lonicerae 2 Radix Rehmanniae 2
Radix Scrophulariae 2 Caulis Loniceraes 2 Radix Arnebiae (Radix Lithospermi)s 2
Production method is as follows:
1, the big gun Squama Manis is worn into coarse powder, Talcum bundle, all the other Chinese medicine fragmentations;
2, the total amount input is carried jar, and the octuple water logging that adds weight was steeped 6 hours, decocted filtration in 40 minutes, adds six times of water gagings again and decocts 30 minutes after-filtration, merges filtrate twice;
3, filtrate concentrates (contracting to 1ml by the 1g crude drug);
4, adding ethanol makes the alcohol amount of containing reach 60-70% to stir evenly, left standstill 24 hours, cross the leaching supernatant, get ethanol and reach relative density more than 1.10;
5, get above-mentioned concentrated solution and add an amount of food starch, dry in the shade, porphyrize, cross 120 mesh sieves and make powder;
6, can incapsulate the in bulk agent by every 0.5g.
Embodiment 2:
Take by weighing raw material (kilogram) by following proportioning:
Radix Angelicae Sinensis 10 Rhizoma Corydalis 2.5 Flos Carthamis 2.5
Pheretima 3 rhizoma sparganic 2.5 Radix Salviae Miltiorrhizaes 8
Semen Persicae 2.5 Rhizoma Curcumae 3 Radix Clematidis 3
Fructus Chaenomelis 3 big gun Squama Manis 6 Radix Bupleuri 2.5
Radix Glycyrrhizae 6 Rhizoma Atractylodis 11 Cortex Phellodendris 11
Radix Achyranthis Bidentatae 13 Semen Coiciss 28 Talcums 13
Caulis Akebiae 5 Flos Lonicerae 13 Radix Rehmanniae 13
Radix Scrophulariae 13 Caulis Loniceraes 28 Radix Arnebiae (Radix Lithospermi)s 9
Production method is with embodiment 1.

Claims (5)

1, the cirsoid Chinese medicine preparation of a kind of treatment is characterized in that being made by following raw materials according:
Radix Angelicae Sinensis 1-15 Rhizoma Corydalis 1-3 Flos Carthami 1-3
Pheretima 1-5 rhizoma sparganic 1-3 Radix Salviae Miltiorrhizae 1-10
Semen Persicae 1-6 Rhizoma Curcumae 1-5 Radix Clematidis 1-5
Fructus Chaenomelis 1-5 big gun Squama Manis 1-9 Radix Bupleuri 1-3
Radix Glycyrrhizae 1-9 Rhizoma Atractylodis 1-12 Cortex Phellodendri 1-12
Radix Achyranthis Bidentatae 1-15 Semen Coicis 1-30 Talcum 1-15
Caulis Akebiae 1-6 Flos Lonicerae 1-15 Radix Rehmanniae 1-15
Radix Scrophulariae 1-15 Caulis Lonicerae 1-30 Radix Arnebiae (Radix Lithospermi) 1-10.
2, according to the cirsoid Chinese medicine preparation of the described a kind of treatment of claim 1, the weight proportion of its each raw material is:
Radix Angelicae Sinensis 3-10 Rhizoma Corydalis 1.5-2.5 Flos Carthami 1.5-2.5
Pheretima 2-3 rhizoma sparganic 1.5-2.5 Radix Salviae Miltiorrhizae 3-8
Semen Persicae 1.5-2.5 Rhizoma Curcumae 2-3 Radix Clematidis 2-3
Fructus Chaenomelis 2-3 big gun Squama Manis 2-6 Radix Bupleuri 1.5-2.5
Radix Glycyrrhizae 2-6 Rhizoma Atractylodis 2-11 Cortex Phellodendri 2-11
Radix Achyranthis Bidentatae 2-13 Semen Coicis 2-28 Talcum 2-13
Caulis Akebiae 2-5 Flos Lonicerae 2-13 Radix Rehmanniae 2-13
Radix Scrophulariae 2-13 Caulis Lonicerae 2-28 Radix Arnebiae (Radix Lithospermi) 2-9
3, according to the cirsoid Chinese medicine preparation of the described a kind of treatment of claim 2, the weight proportion of its each raw material is:
Radix Angelicae Sinensis 5 Rhizoma Corydalis 1.7 Flos Carthamis 1.7
Pheretima 2.5 rhizoma sparganic 1.7 Radix Salviae Miltiorrhizaes 5
Semen Persicae 1.7 Rhizoma Curcumae 2.5 Radix Clematidis 2.5
Fructus Chaenomelis 2.5 big gun Squama Manis 2.5 Radix Bupleuri 1.7
Radix Glycyrrhizae 2.5 Rhizoma Atractylodis 10 Cortex Phellodendris 10
Radix Achyranthis Bidentatae 10 Semen Coiciss 26 Talcums 12
Caulis Akebiae 4 Flos Lonicerae 12 Radix Rehmanniae 12
Radix Scrophulariae 12 Caulis Loniceraes 26 Radix Arnebiae (Radix Lithospermi)s 8
4, preparation is characterized in that as claim 1,2 or 3 described a kind of methods for the treatment of cirsoid Chinese medicine preparation:
(1), the big gun Squama Manis is worn into coarse powder, Talcum bundle, all the other Chinese medicine fragmentations;
(2), the total amount input carries jar, adds the octuple water logging bubble 6 hours of weight, decocts filtration in 40 minutes, adds 30 minutes after-filtration of six times of water gagings decoctions again, merges filtrate twice;
(3), filtrate concentrates;
(4), adding ethanol makes the alcohol amount of containing reach 60-70% to stir evenly, left standstill 24 hours, cross the leaching supernatant, get ethanol and reach relative density more than 1.10;
(5), get above-mentioned concentrated solution and add an amount of food starch, dry in the shade, porphyrize, cross 120 mesh sieves and make powder.
5, according to the described a kind of method for the treatment of cirsoid Chinese medicine preparation of claim 4, it is characterized in that: the powder that makes is incapsulated by every 0.5 gram make the piece agent.
CNB021352933A 2002-08-01 2002-08-01 Chinese medicine prepn for treating varicose vein Expired - Fee Related CN1181867C (en)

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Application Number Priority Date Filing Date Title
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CN1181867C true CN1181867C (en) 2004-12-29

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Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100358540C (en) * 2006-04-19 2008-01-02 云南雄业制药有限公司 Gelata for curing symptom of red buttock of infants, and preparation method
CN101199792B (en) * 2007-12-17 2010-12-01 朱红民 Medicament compound for treating varicocele
CN101204543B (en) * 2007-12-17 2010-06-02 周祝谦 Medicament composition for varixoflowerlimb
CN101204440B (en) * 2007-12-17 2010-06-23 唐煜 Medicine for varicosity
CN101371864B (en) * 2008-10-20 2010-12-22 郝艳青 Medicament for treating varix and preparation method thereof
CN101485867B (en) * 2009-03-02 2011-09-07 安士强 Chinese medicinal composition for treating varix and preparation method thereof
CN101843676B (en) * 2010-04-28 2011-07-27 于洋 Chinese medicinal preparation for treating varicosity diseases and preparation method thereof
CN103007113A (en) * 2013-01-11 2013-04-03 来玉民 Traditional Chinese medicinal composition for treating phlebitis and method for preparing same
CN104306532A (en) * 2014-09-09 2015-01-28 宋永花 Traditional Chinese medicine used for treating varicose veins of lower limbs

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