CN118161421A - Preparation method of gel-type oxygen-containing water with stable oxygen-containing water in gel network structure and improved long-term stability, and cosmetic composition containing gel-type oxygen-containing water - Google Patents
Preparation method of gel-type oxygen-containing water with stable oxygen-containing water in gel network structure and improved long-term stability, and cosmetic composition containing gel-type oxygen-containing water Download PDFInfo
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- CN118161421A CN118161421A CN202310919521.6A CN202310919521A CN118161421A CN 118161421 A CN118161421 A CN 118161421A CN 202310919521 A CN202310919521 A CN 202310919521A CN 118161421 A CN118161421 A CN 118161421A
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- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 title claims abstract description 221
- 239000001301 oxygen Substances 0.000 title claims abstract description 221
- 229910052760 oxygen Inorganic materials 0.000 title claims abstract description 221
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 199
- 239000002537 cosmetic Substances 0.000 title claims abstract description 29
- 239000000203 mixture Substances 0.000 title claims abstract description 26
- 230000007774 longterm Effects 0.000 title abstract description 12
- 238000002360 preparation method Methods 0.000 title description 20
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims abstract description 74
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- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 63
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- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 63
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- WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 description 2
- 201000004384 Alopecia Diseases 0.000 description 2
- 102100028314 Filaggrin Human genes 0.000 description 2
- 101710088660 Filaggrin Proteins 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
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- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 description 1
- 241000711573 Coronaviridae Species 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
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- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 description 1
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- BAEIUCDXXHCJQG-UHFFFAOYSA-N germanium;hydrate Chemical compound O.[Ge] BAEIUCDXXHCJQG-UHFFFAOYSA-N 0.000 description 1
- 230000036074 healthy skin Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
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- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 description 1
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
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- Cosmetics (AREA)
- Dispersion Chemistry (AREA)
- Inorganic Chemistry (AREA)
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Abstract
The present invention relates to a method for preparing gel-type oxygen-containing water for stabilizing oxygen-containing water in a gel network structure to improve long-term stability and a cosmetic composition containing the same, which improves dissolved oxygen amount and improves stability by capturing oxygen-containing water in the gel network structure, and relates to the following cosmetic composition: in order to trap oxygen-containing water in the gel network structure, polyethylene glycol-240/hexamethylene diisocyanate copolymer di-decyl tetradecyl polyether-20 ether is utilized and sodium hyaluronate or sodium hyaluronate is added to contain dissolved oxygen, so that the stability is maintained to improve long-term stability, and simultaneously, the collagen synthesis, the silk fibroin synthesis and the elastin synthesis are improved, and the effects of moisture preservation, skin improvement and scalp improvement are exerted.
Description
Technical Field
The present invention relates to a method for preparing gel-type oxygen water, which increases the amount of dissolved oxygen and improves the stability by entrapping the oxygen water in a gel network structure, and a cosmetic composition containing the gel-type oxygen water prepared by the above method, and more particularly, to the following cosmetic composition: in order to trap oxygen-containing water in the gel network structure, polyethylene glycol-240/hexamethylene diisocyanate copolymer bis-decyl tetradecyl polyether-20 ETHER (PEG-240/HDI COPOLYMER BIS-DECYLTETRADECETH-20 ETHER) is utilized and sodium hyaluronate (Sodium Hyaluronate) or sodium hyaluronate (Sodium Acetylated Hyaluronate) is added to contain dissolved oxygen, so that the skin improving effect and moisturizing effect are achieved while the long-term stability is stably maintained to improve.
Background
Recently, since the degree of atmospheric pollution is deteriorated by the new coronavirus pneumonia and the omnikoram, dust, soot, and the like, in the case where oxygen in the air is insufficient or contaminated, there is a case where oxygen supply by breathing is not smooth. And, thereby, the supply of oxygen through the skin is also caused to be not smooth, and various skin problems occur, in which oxygen also plays an important role. On the other hand, the so far marketed cosmetics have been left on the conceptual and comment level, and have had a disadvantage of insufficient actual efficacy. Therefore, it is most important for oxygen cosmetics to scientifically study the skin and develop stable oxygen to enable long-term use.
Oxygen in the atmosphere, 21% of which is used as an energy source for the human body, acts as a "battery" in all our activities requiring energy, including digestion. Oxygen absorbed into the body is blown into cells everywhere through the transport of blood. On the other hand, if oxygen in the body is lacking by only 5%, dyspnea occurs, and if oxygen supply to the brain is interrupted for 5 minutes, brain cells start to die. For "skin" surrounding our whole body, the supply of oxygen is also important, and if the oxygen content in the air is reduced to 18% -19%, the skin is perceived to be warm and extremely dry, and it is usually better to re-inhale fresh air.
On the other hand, although there are currently commercialized oxygen cosmetics, oxygen is hardly present or is present in an extremely small amount when the oxygen concentration is measured, and is insufficient to exert substantial efficacy as an oxygen cosmetic. In general, materials mixed in cosmetics containing oxygen should be stable against oxygen change, and thus, selection and stabilization techniques of raw materials should be emphasized not to rancidity.
Accordingly, the present invention relates to a method for preparing gel-type oxygen-containing water, which increases the dissolved oxygen amount and improves the stability by entrapping the oxygen-containing water in a gel network structure, and it is intended to develop a cosmetic composition having long-term stability and a moisturizing effect while having a skin improvement effect by including the same.
Prior art literature
Patent literature
Patent document 1: cosmetic compositions for improving skin color or improving elasticity containing seaweed extract containing a large amount of dissolved oxygen are disclosed in korean patent No. 10-1798055 (authorized at 2017, 11, 09).
Patent document 2: cosmetic compositions for moisturizing and improving skin barrier comprising nanoliposomes containing oxygen-containing water and ceramide and a method for preparing the same are disclosed in korean patent No. 10-2325570 (2021, 11, 08).
Disclosure of Invention
Technical problem
The present invention provides a method for preparing gel-type oxygen water, which increases dissolved oxygen content and stability by trapping oxygen water in a gel network (gel network) structure, and to this end, provides a cosmetic composition containing the gel-type oxygen water as follows: the polyethylene glycol-240/hexamethylene diisocyanate copolymer di-decyl tetradecyl polyether-20 ether component is utilized, and sodium hyaluronate (Sodium Hyaluronate) or sodium hyaluronate (Sodium Acetylated Hyaluronate) is added to the mixture to improve long-term stability and simultaneously effectively capture oxygen so as to exert excellent skin improvement and moisturizing effects.
Technical proposal
The invention provides a preparation method of gel-type oxygen-containing water, which is characterized by comprising the following steps: a step (a) of injecting oxygen into pure water and dissolving to prepare oxygen-containing water; step (b), after the step (a), injecting polyethylene glycol-240/hexamethylene diisocyanate copolymer bis-decyl tetradecyl polyether-20 ether into the oxygen-containing water prepared in the step (a) to form a gel network structure; and a step (c) of adding sodium hyaluronate or sodium hyaluronate to stabilize the gel network structure prepared in the step (b) after the step (b).
The process for producing the gel-type oxygen-containing water of the present invention is characterized in that the polyethylene glycol-240/hexamethylene diisocyanate copolymer bis-decyl tetradecyl polyether-20 ether used in the above step (b) may be added in an amount of 0.001 to 5% by weight based on the total amount of the finally produced gel-type oxygen-containing water.
The method for producing gel-type oxygen-containing water of the present invention is characterized in that, if sodium hyaluronate is used in the step (c), sodium hyaluronate may be added in an amount of 0.0005 to 1% by weight based on the total amount of the finally produced gel-type oxygen-containing water, or if sodium hyaluronate is used in the step (c), sodium hyaluronate may be added in an amount of 0.00001 to 1% by weight based on the total amount of the finally produced gel-type oxygen-containing water.
The method for producing the gel-type oxygen-containing water of the present invention is characterized in that the oxygen content of the oxygen-containing water of the step (a) may be 0.01ppm to 300ppm.
The method for producing gel-type oxygen-containing water of the present invention is characterized in that the skin functional substance that does not react with oxygen can be added to the pure water of the above step (a) together with oxygen and dissolved.
The present invention provides a gel-type oxygen-containing water prepared by the method for preparing a gel-type oxygen-containing water of the present invention.
The present invention provides a cosmetic composition containing the gel-type oxygen-containing water of the present invention.
ADVANTAGEOUS EFFECTS OF INVENTION
The present invention can provide a method for preparing gel-type oxygen-containing water, which increases dissolved oxygen amount and stability by trapping oxygen-containing water in a gel network (gel network) structure, and a cosmetic composition, which is prepared by the above method, increases long-term stability and is effective in skin improvement and moisturization.
Drawings
FIG. 1 shows the molecular structure of polyethylene glycol-240/hexamethylene diisocyanate copolymer bis-decyl tetradecyl polyether-20 ether, sodium hyaluronate and acetylated sodium hyaluronate.
Fig. 2 is a diagram schematically showing a method for producing gel-type oxygen-containing water according to the present invention.
Fig. 3 shows the way in which the cosmetic composition containing oxygenated water of the invention is absorbed into the skin in a human skin structure.
Fig. 4 is a block diagram showing the principle of stabilization by enclosing dissolved oxygen in a gel network structure.
Fig. 5 (a) is a photograph showing an OXYGEN generating apparatus (OXYGEN-NBS 30 type) used in the present invention, and (B) is a photograph showing a dissolved OXYGEN measuring apparatus.
FIG. 6 is an actual photograph showing gelation phenomenon when a mixture comprising polyethylene glycol-240/hexamethylene diisocyanate copolymer bis-decyl tetradecyl polyether-20 ether is dissolved in water.
FIG. 7 is a graph showing the result of the experiment of the thixotropic phenomenon using 3 weight percent of a polymer forming a gel network (polyethylene glycol-240/hexamethylene diisocyanate copolymer bis-decyl tetradecyl polyether-20 ether).
Fig. 8 is a schematic diagram showing the mechanism of action exhibited when the oxygen-containing water of the present invention is absorbed by the skin.
FIG. 9 is a bar graph showing the results of performing a collagen synthesis rate test according to the concentration of oxygen-containing water of the present invention.
FIG. 10 is a bar graph showing the results of experiments on the expression level of filaggrin according to the concentration of oxygen-containing water of the present invention at the cellular level.
Fig. 11 is a graph showing the result of measuring the scalp moisturizing effect of the oxygen-containing water of the present invention.
Fig. 12 is a bar graph showing the results of a clinical experiment of skin elasticity of a toner using the oxygen-containing water of the present invention.
Fig. 13 is a representative photograph showing the effect of improving the skin of a toner using the oxygen-containing water of the present invention observed after 4 weeks of clinical experiment.
FIG. 14 is a bar graph showing cell viability as the concentration of oxygenated water of the present invention increases.
Detailed Description
The invention provides a preparation method of gel-type oxygen-containing water, which is characterized by comprising the following steps: a step (a) of injecting oxygen into pure water and dissolving to prepare oxygen-containing water; step (b), after the step (a), injecting polyethylene glycol-240/hexamethylene diisocyanate copolymer bis-decyl tetradecyl polyether-20 ether into the oxygen-containing water prepared in the step (a) to form a gel network structure; and a step (c) of adding sodium hyaluronate or sodium hyaluronate to stabilize the gel network structure prepared in the step (b) after the step (b).
The present invention has been made in an effort to provide a method for preparing gel-type oxygen-containing water, which can improve the dissolved oxygen content and the stability by trapping the oxygen-containing water in a gel network (gel network) structure, and a cosmetic composition containing the same, which can stably contain highly concentrated oxygen-containing water for a long period of time and can exert remarkable effects in skin improvement, moisture retention, and the like, unlike conventional oxygen-containing water, which has low stability and thus reduced cosmetic availability and effect due to problems such as easy evaporation of oxygen-containing water, oxygen drainage, and the like.
On the other hand, in the method for producing gel-type oxygen-containing water of the present invention, it is preferable to add 0.001 to 5% by weight of the polyethylene glycol-240/hexamethylene diisocyanate copolymer bis-decyl tetradecyl polyether-20 ether used in the above step (b), based on the total amount of the finally produced gel-type oxygen-containing water. More preferably, 0.01 to 3 weight percent of the polyethylene glycol-240/hexamethylene diisocyanate copolymer bis-decyl tetradecyl polyether-20 ether used in the above step (b) is added based on the total amount of finally prepared gel-type oxygen-containing water.
In the method for producing gel-type oxygen-containing water of the present invention, it is preferable that, if sodium hyaluronate is used in the step (c), 0.0005 to 1% by weight of sodium hyaluronate is added based on the total amount of the finally produced gel-type oxygen-containing water, or if sodium hyaluronate is used in the step (c), 0.00001 to 1% by weight of sodium hyaluronate is added based on the total amount of the finally produced gel-type oxygen-containing water. More preferably, 0.001 to 0.5 weight percent of sodium hyaluronate is added based on the total amount of the finally prepared gel-type oxygen-containing water, or 0.0001 to 0.3 weight percent of acetylated sodium hyaluronate is added based on the total amount of the finally prepared gel-type oxygen-containing water.
On the other hand, FIG. 1 shows the molecular structures of the representative substances of polyethylene glycol-240/hexamethylene diisocyanate copolymer bis-decyl tetradecyl polyether-20 ether, sodium hyaluronate and sodium hyaluronate acetylated to form the gel network structure of the present invention, and FIG. 2 is a diagram schematically showing the preparation method of the gel-type oxygen-containing water of the present invention.
In the method for producing gel-type oxygen-containing water of the present invention, on the other hand, the oxygen content of the oxygen-containing water of the above step (a) may be 0.01ppm to 300ppm.
In the method for producing gel-type oxygen-containing water of the present invention, the skin functional substance that does not react with oxygen may be added to the pure water of the step (a) together with oxygen and dissolved.
The invention provides gel-type oxygen-containing water prepared by the method, which is characterized in that the gel-type oxygen-containing water can have thixotropic (thixotropy) property. The thixotropic phenomenon is a phenomenon in which when an external force such as shaking mixing is applied to a high-concentration colloidal solution or a polymer solution, fluidity is exhibited, and when the external force is eliminated, fluidity is not exhibited. The following experiments confirm that the oxygen-containing water of the present invention is gel-like, but has thixotropic properties that it becomes liquid when shaken or applied with an external force and returns to gel-like when the external force is removed.
The present invention also provides a cosmetic composition containing the gel-type oxygen-containing water. The cosmetic composition containing gel-type oxygen-containing water of the present invention can exert effects such as collagen synthesis, silk fibroin synthesis, elastin synthesis, moisture retention, skin improvement, scalp improvement, etc. Fig. 3 shows the way in which the cosmetic composition containing gelled oxygen water of the invention is absorbed into the skin in a skin structure of a human.
The method for producing the gel-type oxygen-containing water of the present invention will be specifically described below by subdividing the steps.
Step (a): preparation of oxygen-containing Water
This step is a process of injecting oxygen into pure water and dissolving to prepare oxygen-containing water.
In this case, water such as mineral water, seawater, deep water, spring water, germanium water, etc., may be used in addition to the above pure water, and more preferably, water having a ph of 4.5 to 9.9 and a viscosity of 1cps to 3000cps or pure water may be used.
Alternatively, oxygen may be injected into the above-selected pure water or water using an oxygen generating device or dissolved using pure oxygen in this step. In this case, the amount of dissolved oxygen can be stabilized by adjusting the dissolution time to dissolve a concentration higher than a desired concentration according to the type and performance of the apparatus. On the other hand, in this step, the oxygen content of the oxygen-containing water is preferably set to 0.01ppm to 300ppm.
On the other hand, in this step, a skin functional substance that does not react with oxygen may be added to the pure water together with oxygen and dissolved. In this case, acetyl hexapeptide-8 or the like can be used as the skin functional substance that does not react with oxygen.
Step (b): injection of gel network polymers
This step is a process of forming a gel network structure by injecting polyethylene glycol-240/hexamethylene diisocyanate copolymer bis-decyl tetradecyl polyether-20 ether into the oxygen-containing water prepared in the above step (a) after the above step (a). In this case, it is preferable to add 0.001 to 5 weight percent of the above-mentioned polyethylene glycol-240/hexamethylene diisocyanate copolymer bis-decyl tetradecyl polyether-20 ether based on the total amount of the finally prepared gel-type oxygen-containing water.
On the other hand, polyethylene glycol-240/hexamethylene diisocyanate copolymer bis-decyl tetradecyl polyether-20 ether is a component used for trapping oxygen-containing water in a gel network structure, and has the following characteristics: as a polymer having thixotropic properties, water can be adsorbed by tens of times, and when subjected to shear stress (SHEAR STRESS), the polymer becomes as viscous as water, and when left to stand for a predetermined period of time, a gel can be formed to trap a large amount of dissolved oxygen.
On the other hand, fig. 4 is a structural diagram showing the principle of stabilization by sealing dissolved oxygen into a gel network structure, and as shown in fig. 4, a polymer such as a spider web generally forms a network and may have an ability to adsorb hundreds of times of water. Therefore, in this step, a large amount of dissolved oxygen can be enclosed with the injection of the high molecular polymer "polyethylene glycol-240/hexamethylene diisocyanate copolymer bis-decyl tetradecyl polyether-20 ether", and the stability can be maintained for a long period of time.
Step (c): adding auxiliary polymer to stabilize oxygen-containing water
This step is a process of stabilizing the gel network structure prepared in the above step (b) by adding sodium hyaluronate or sodium hyaluronate after the above step (b).
In this step, sodium hyaluronate or sodium hyaluronate is added as an auxiliary polymer to the oxo water having a gel network structure formed by injecting the above polyethylene glycol-240/hexamethylene diisocyanate copolymer bis-decyl tetradecyl polyether-20 ether to stabilize the oxo water. In this case, preferably, if sodium hyaluronate is used, 0.0005 to 1 weight percent sodium hyaluronate is added based on the total amount of gel-type oxygen-containing water finally prepared, and if sodium hyaluronate is used, 0.00001 to 1 weight percent sodium hyaluronate is added based on the total amount of gel-type oxygen-containing water finally prepared. More preferably, if sodium hyaluronate is used, 0.001 to 0.5 weight percent sodium hyaluronate based on the total amount of gel-type oxygen-containing water finally prepared, and if sodium hyaluronate is used, 0.0001 to 0.3 weight percent sodium hyaluronate based on the total amount of gel-type oxygen-containing water finally prepared.
On the other hand, after the polymer gel network polymer (polyethylene glycol-240/hexamethylene diisocyanate copolymer bis-decyl tetradecyl polyether-20 ether) is injected in the step (b), sodium hyaluronate or acetylated sodium hyaluronate can be added as an auxiliary polymer to bind with hydroxyl (OH) groups bound to the gel network structure to dissolve more oxygen, and can contain more dissolved oxygen in the gel network structure to keep stable. In this case, the sodium hyaluronate or the sodium hyaluronate may be used alone, or preferably, sodium hyaluronate and sodium hyaluronate are used together.
On the other hand, after adding sodium hyaluronate or sodium hyaluronate as an auxiliary polymer to stabilize oxygen-containing water in this step, it is preferable to fill in a laminated three-layer package. In this case, the laminated three-layer bag may be replaced by a common pet container or plastic container, but for more stable long-term storage, storage in a laminated three-layer tube is a more preferable method.
As described above, with the oxygen-containing water stably enclosed in the gel network structure by the above-described steps, the gel-type oxygen-containing water of the present invention having high long-term stability can be prepared.
On the other hand, it was confirmed by the experiments of the present invention described below that the gel-type oxygen-containing water of the present invention prepared according to the above-described method can exert effects in skin collagen synthesis, increasing the expression level of silk fibroin, promoting elastin synthesis, moisturizing, scalp improvement and skin improvement, and thus can be used as a cosmetic composition.
Hereinafter, the present invention will be described in more detail with reference to the following examples and experimental examples. However, the scope of the claims of the present invention is not limited to the following examples and experimental examples, and includes modifications of the technical ideas equivalent to these.
Example 1: preparation of oxo water comprising polyethylene glycol-240/hexamethylene diisocyanate copolymer bis-decyl tetradecyl polyether-20 ether
In this example, after oxygen was injected into pure water and dissolved to prepare oxygen-containing water, polyethylene glycol-240/hexamethylene diisocyanate copolymer bis-decyltetradecylether-20 ether, sodium hyaluronate and sodium hyaluronate were added in combination as shown in the following table 1 to prepare oxygen-containing water of examples 1-1 to 1-5.
On the other hand, comparative example 1 (dissolved oxygen in pure water) was prepared without using polyethylene glycol-240/hexamethylene diisocyanate copolymer bis-decyl tetradecyl polyether-20 ether, sodium hyaluronate and sodium hyaluronate as a comparative group.
The oxygen injection conditions and the dissolved oxygen amounts of examples 1-1 to 1-5 and comparative example 1, and examples 1-1 to 1-5 and comparative example 1 are summarized in tables 1 and 2 below.
TABLE 1
TABLE 2
As shown in tables 1 and 2, the final oxygen concentration and the oxygen concentration after 24 hours in examples 1-1 to 1-5 of the present invention were significantly higher than those in comparative example 1 in which oxygen was dissolved only in pure water, and in particular, the retention efficiency of the oxygen-containing water in examples 1-3 to 1-5 was 80% or more, and it was found that a large amount of dissolved oxygen could be effectively retained for a long period of time. On the other hand, fig. 5 is a photograph showing the oxygen generating apparatus and the dissolved oxygen measuring apparatus used in the present invention.
Example 2: preparation of oxo water by adding active ingredient to oxo water containing polyethylene glycol-240/hexamethylene diisocyanate copolymer bis-decyl tetradecyl polyether-20 ether, sodium hyaluronate and sodium hyaluronate
In this example, it was confirmed whether or not a component that could affect the oxygen dissolution ability was present, and as an example, acetyl hexapeptide-8 was selected to prepare the oxygen-containing water of the present invention.
In this example, oxygen-containing water of examples 2-1 to 2-4 containing acetyl hexapeptide-8 (AHP-8) as an active ingredient in addition to polyethylene glycol-240/hexamethylene diisocyanate copolymer bis-decyl tetradecyl polyether-20 ether, sodium hyaluronate and sodium hyaluronate was prepared. On the other hand, acetyl hexapeptide-8 (AHP-8) was added to pure water together with oxygen and dissolved to prepare examples 2-1 to 2-4, and comparative example 2, which did not use acetyl hexapeptide-8, was prepared as a comparative group.
The oxygen injection conditions and the dissolved oxygen amounts of examples 2-1 to 2-4 and comparative example 2, and examples 2-1 to 2-4 and comparative example 2 are summarized in tables 3 and 4 below.
TABLE 3 Table 3
TABLE 4 Table 4
As shown in tables 3 and 4, examples 2-1 to 2-4 and comparative example 2 of the present invention all showed excellent final oxygen concentration and retention efficiency, but it was confirmed that the oxygen concentration and retention efficiency were more excellent with the increase in the amount of acetyl hexapeptide-8 added in examples 2-1 to 2-4.
That is, although it is possible to prepare oxygen-containing water having an excellent dissolved oxygen content and high retention efficiency by adding polyethylene glycol-240/hexamethylene diisocyanate copolymer bis-decyl tetradecyl polyether-20 ether, sodium hyaluronate and sodium hyaluronate to oxygen-containing water prepared by dissolving only oxygen in pure water, it is known that oxygen-containing water having a more excellent retention efficiency can be prepared by taking advantage of the synergistic effect of acetyl hexapeptide-8 when it is prepared by adding oxygen together.
Experimental example 1: confirmation of gel Forming ability and thixotropic Properties with concentration of polyethylene glycol-240/hexamethylene diisocyanate copolymer bis-decyl tetradecyl polyether-20 Ether
In this experiment, the gel forming ability and thixotropic properties with the concentration of the polyethylene glycol-240/hexamethylene diisocyanate copolymer bis-decyl tetradecyl polyether-20 ether were confirmed.
First, as a result of confirming the gel forming ability, as shown in fig. 6, it was confirmed that all of 3 samples formed gel well. On the other hand, FIG. 6 is a practical photograph showing gelation phenomenon when polyethylene glycol-240/hexamethylene diisocyanate copolymer bis-decyl tetradecyl polyether-20 ether is dissolved in water, preparing a low concentration at 0.01 weight percent of polyethylene glycol-240/hexamethylene diisocyanate copolymer bis-decyl tetradecyl polyether-20 ether, preparing a medium concentration at 3 weight percent, and preparing a high concentration at 6 weight percent.
As shown in FIG. 6, gels having various viscosities were formed at a low concentration (0.01%), a medium concentration (3%), and a high concentration (6%), and gels were well formed in all 3 samples, and in particular, it was confirmed that the gel forming ability was also increased with an increase in the concentration of the polyethylene glycol-240/hexamethylene diisocyanate copolymer bis-decyl tetradecyl polyether-20 ether.
Thus, since the oxo water of the present invention contains polyethylene glycol-240/hexamethylene diisocyanate copolymer bis-decyl tetradecyl polyether-20 ether, it is known that oxo water excellent in gel forming ability and stability can be produced as compared with the case of using oxo water in which oxygen is simply dissolved in pure water.
As described above, the present invention can prepare "stability improved" oxo water which does not cause oxo water to be easily evaporated or oxygen to be discharged by using the principle that dissolved oxygen is stably locked by using the gel network structure formed by the polyethylene glycol-240/hexamethylene diisocyanate copolymer bis-decyl tetradecyl polyether-20 ether.
On the other hand, fig. 7 is a photograph showing the thixotropic phenomenon by using 3 weight percent of a polymer forming a gel network (polyethylene glycol-240/hexamethylene diisocyanate copolymer bis-decyl tetradecyl polyether-20 ether), and as shown in fig. 7, it was confirmed that the gel formed initially, became a liquid like water when pressure or shaking was applied, and recovered to a gel with high viscosity when it was left to stand again.
Thus, the oxygen-containing water prepared by adding the polyethylene glycol-240/hexamethylene diisocyanate copolymer bis-decyl tetradecyl polyether-20 ether according to the present invention has thixotropic properties, can absorb water swelling (swelling) by several tens times or more, and becomes a liquid state by lowering viscosity upon shaking or application of shear stress (shear), and thus can prevent evaporation of oxygen and remain stable even after long-term storage.
On the other hand, fig. 8 is a schematic view showing the mechanism of action exhibited when the oxygenated water of the present invention is absorbed by the skin, showing that the oxygenated water may have various physiological activities after being absorbed by the skin. As shown in fig. 8, the skin has a structure in which epidermis, a junction between dermis and epidermis, dermis and subcutaneous tissue are connected, and the oxygenated water of the present invention can strengthen collagen at a portion connecting dermis and epidermis to help improve wrinkles, and particularly can contribute to the synthesis of collagen-4 and collagen-7. In addition, elastin as an elastic fiber may be affected, and the moisturizing effect may be improved by promoting synthesis of silk fibroin as a moisturizing factor. Also, the skin barrier strengthening effect can be exerted by correlating with factors such as laminin- γ1, laminin- γ5, laminin- γ10, laminin- γ11, etc.
On the other hand, the above-described effects will be specifically confirmed in experimental examples 2 to 5 described below.
Experimental example 2: confirmation of collagen Synthesis Rate when oxygen-containing Water of the present invention was used
In this experiment, experiments for confirming the collagen synthesis rate with the concentration of oxygen-containing water were conducted using the oxygen-containing water prepared in examples 1 to 3 above.
FIG. 9 is a bar graph showing the results of carrying out a collagen synthesis rate test according to the concentration of oxo water of the present invention, as shown in FIG. 9, in placebo (Placebo) (control group) to which oxo water was not added, the collagen synthesis rate was 105.2%, showing a level of little activity, whereas when oxo water was added at 5ppm, the collagen synthesis rate was 126.5%, when 10ppm was added, 131.6%, when 30ppm was added, 139.6%, and a sharp increase in collagen synthesis rate was confirmed.
On the other hand, acetyl hexapeptide-8 (AHP-8) is a component that contributes to improvement of wrinkles, improvement of skin elasticity, etc. by collagen synthesis effect, and as shown in FIG. 9, the addition of 5ppm of AHP-8 alone shows a collagen synthesis rate of 117.8%. However, when 5ppm of oxygen-containing water (examples 1-3) and 5ppm of AHP-8 were added simultaneously, a significant increase in collagen synthesis rate of 149.7% was confirmed. That is, it is understood that the oxo water of the present invention can exert advantageous effects on the skin such as wrinkle improvement by significantly increasing the collagen synthesis rate.
Experimental example 3: confirmation of the expression level of filaggrin Using the oxygen Water of the present invention
In this experiment, an experiment for confirming the expression level of silk fibroin according to the concentration of oxo water was performed using oxo water prepared in the above examples 1 to 3.
FIG. 10 is a bar graph showing the results of experiments on the expression level of silk fibroin at the cellular level according to the concentration of oxo water of the present invention, in a placebo (control group) to which oxo water was not added, the silk fibroin expression level was 108.6%, showing a level of almost no activity, whereas when oxo water was added at 5ppm, the silk fibroin expression level was 138.5%, 148.7% when 10ppm was added, and 157.3% when 30ppm was added, confirming a sharp increase in silk fibroin expression level.
Further, when AHP-8 (acetyl hexapeptide-8) was added alone at 5ppm, the expression level of silk fibroin was 113.2%. However, when 5ppm of oxo water (examples 1-3) and 5ppm of AHP-8 were added simultaneously, it was confirmed that the amount of silk fibroin expressed increased significantly to 145.5%. That is, it is understood that the oxygen-containing water of the present invention can exert advantageous effects on the skin such as improvement of skin moisture by significantly increasing the expression level of silk fibroin.
Experimental example 4: confirm the scalp moisturizing effect
In this experiment, experiments for confirming the scalp moisturizing effect of the oxygen-containing water of the present invention were performed using the oxygen-containing water prepared in the above examples 1 to 3. The test was carried out for 4 weeks with shampoo and water washing 1 time a day in the morning for 7 subjects, and the moisturizing ability was measured at 1-week intervals.
Fig. 11 is a graph showing the results of measuring the scalp moisturizing effect of the oxygen-containing water of the present invention, wherein the scalp moisturizing effect was 3% before the application of the shampoo, and the moisturizing effect was 17.25% after the addition of 5ppm of oxygen-containing water together with the shampoo for 4 weeks, and it was confirmed that the scalp moisturizing effect was improved by 5.7 times or more than before the application.
On the other hand, when 5ppm of oxygen-containing water and 5ppm of AHP-8 were added together with the shampoo, it was confirmed that the scalp moisturization was improved by more than 2 times before the shampoo was applied.
That is, it is known that the oxygen-containing water of the present invention exhibits a remarkably improved scalp moisturizing effect, and thus can exert an advantageous effect in scalp improvement.
Experimental example 5: confirm skin elasticity and skin improving effect
In this experiment, the toner of preparation example 1 and the toner of comparative example 3 were prepared in accordance with the combination of table 5 below, and an experiment for confirming the skin elasticity and the skin improvement effect was performed. Skin elasticity confirmation test skin elasticity was measured (using a skin elasticity tester) for a total of 4 weeks by applying toner to the face twice a day in the morning and at night, with an interval of 1 week.
Table 5 below shows the combinations of the toners of preparation example 1 containing an oxygen-containing water and the toner of comparative example 3 in which no oxygen-containing water was used.
TABLE 5
Toner combinations of preparation example 1 and comparative example 3
FIG. 12 is a bar graph showing the results of clinical experiments on skin elasticity using the toner of preparation example 1 (containing the oxygen-containing water of examples 1 to 3) and the toner of comparative example 3 (not containing the oxygen-containing water) prepared in accordance with the above-described combination, and as shown in FIG. 12, when the toner of preparation example 1 containing the oxygen-containing water of the present invention was used, the elasticity increased greatly from the time of 1 week, and after 4 weeks, the increase in 10.75% was confirmed, and it was confirmed that the skin elasticity was significantly increased as compared with that before use and in comparative example 3.
On the other hand, fig. 13 shows the results of examining the skin improvement effect by photographing the skin with a microscope after 4 weeks using the toner of preparation example 1 (containing the oxygen-containing water of examples 1 to 3) and the toner of comparative example 3 (not containing the oxygen-containing water) of the present invention. As shown in fig. 13, before the toner of preparation example 1 was used, the skin surface condition was observed to be rough, and the group using the toner of comparative example 3 also observed to have wrinkles and formation of a rough keratin, whereas the toner of preparation example 1 observed to have a healthy skin condition in which a healthy keratin was formed finely.
Experimental example 6: confirmation of cell viability with increasing concentration of oxygenated water according to the present invention
In this experiment, it was intended to confirm the cell viability with increasing concentration of oxygenated water according to the present invention.
FIG. 14 is a bar graph showing cell viability as the concentration of oxygenated water of the present invention increases. As shown in fig. 14, even though the dissolved oxygen in the oxo water of the present invention was increased, the survival rate of cells was not greatly changed, thereby confirming that the oxo water of the present invention was not cytotoxic.
As described above, according to the present invention, oxygen is injected into pure water and dissolved to prepare oxygen-containing water, and after the polyethylene glycol-240/hexamethylene diisocyanate copolymer bis-decyl tetradecyl polyether-20 ether is injected to form a gel network structure, sodium hyaluronate or other auxiliary polymers are added to stabilize the gel network structure, thereby effectively encapsulating oxygen-containing water in the gel network structure, and thus stable gel can be formed, and with the inclusion of the gel-type oxygen-containing water, a cosmetic composition having excellent collagen synthesis rate, silk fibroin expression level, and exhibiting outstanding effects such as scalp moisturization, skin improvement, etc. can be prepared.
On the other hand, the following tables 6 to 10 show the results of the observation of the preparation of shampoo, cleansing liquid, jelly, active oxygen emulsion, and hair conditioner for preventing hair loss, respectively, by using the formulation examples of the cosmetic compositions prepared from the oxygen-containing water of examples 1 to 3 and examples 2 to 3.
TABLE 6
Shampoo for preventing alopecia prepared by using the oxygen-containing water
TABLE 7 preparation of cleansing lotion using the oxygen-containing water of the present invention
TABLE 8 preparation of jelly cream using the oxygen-containing water of the present invention
TABLE 9
Preparation of active oxygen emulsion cream by using the oxygen-containing water of the invention
Table 10
Hair conditioner prepared by using oxygen-containing water
As described above, various cosmetic compositions such as shampoo, cleansing liquid, jelly, active oxygen emulsion, and hair conditioner for preventing alopecia can be prepared using the oxygen-containing water of the present invention, and it is known that the gel-type oxygen-containing water of the present invention can be effectively used in various cosmetic compositions.
Claims (7)
1. A method for preparing gel-type oxygen-containing water, which is characterized by comprising the following steps:
a step (a) of injecting oxygen into pure water and dissolving to prepare oxygen-containing water;
Step (b), after the step (a), injecting polyethylene glycol-240/hexamethylene diisocyanate copolymer bis-decyl tetradecyl polyether-20 ether into the oxygen-containing water prepared in the step (a) to form a gel network structure; and
And (c) after the step (b), adding sodium hyaluronate or sodium hyaluronate to stabilize the gel network structure prepared in the step (b).
2. The method for preparing gel-type oxygen-containing water according to claim 1, wherein the polyethylene glycol-240/hexamethylene diisocyanate copolymer bis-decyl tetradecyl polyether-20 ether used in the above step (b) is added in an amount of 0.001 to 5% by weight based on the total amount of the finally prepared gel-type oxygen-containing water.
3. The method for preparing gel-type oxygen-containing water according to claim 1, wherein,
If sodium hyaluronate is used in step (c), 0.0005 wt% to 1 wt% sodium hyaluronate, or
If sodium hyaluronate is used in the above step (c), 0.00001 to 1 weight percent sodium hyaluronate is added based on the total amount of the finally prepared gel-type oxygen-containing water.
4. The method for producing gel-type oxygen-containing water according to claim 1, wherein the oxygen content of the oxygen-containing water in the step (a) is 0.01ppm to 300ppm.
5. The method for producing gel-type oxygen-containing water according to claim 1, wherein the oxygen-unreacted skin functional substance is added to the pure water of the step (a) together with oxygen and dissolved therein.
6. A gel-type oxygen-containing water, characterized by being prepared by the method for preparing a gel-type oxygen-containing water according to claim 1 or 5.
7. A cosmetic composition comprising the gel-type oxygen-containing water according to claim 6.
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