CN118159293A - 抗癌药、抗癌药的前药、在体外杀灭癌细胞的方法、癌症的治疗方法、以及癌症的治疗装置 - Google Patents

抗癌药、抗癌药的前药、在体外杀灭癌细胞的方法、癌症的治疗方法、以及癌症的治疗装置 Download PDF

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Publication number
CN118159293A
CN118159293A CN202280070780.XA CN202280070780A CN118159293A CN 118159293 A CN118159293 A CN 118159293A CN 202280070780 A CN202280070780 A CN 202280070780A CN 118159293 A CN118159293 A CN 118159293A
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China
Prior art keywords
nitrogen
cancer cells
cancer
cells
prodrug
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Pending
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CN202280070780.XA
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English (en)
Chinese (zh)
Inventor
岩田康嗣
松井裕史
铃木石根
铃木裕司
富田加奈子
杨天景
池田贵文
黒川宏美
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Taiyang Service Co ltd
National Institute of Advanced Industrial Science and Technology AIST
University of Tsukuba NUC
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Taiyang Service Co ltd
National Institute of Advanced Industrial Science and Technology AIST
University of Tsukuba NUC
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Publication of CN118159293A publication Critical patent/CN118159293A/zh
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    • A—HUMAN NECESSITIES
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    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0061—5-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA
    • A—HUMAN NECESSITIES
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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CN202280070780.XA 2021-10-20 2022-10-20 抗癌药、抗癌药的前药、在体外杀灭癌细胞的方法、癌症的治疗方法、以及癌症的治疗装置 Pending CN118159293A (zh)

Applications Claiming Priority (3)

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JP2021-172003 2021-10-20
JP2021172003 2021-10-20
PCT/JP2022/039079 WO2023068325A1 (ja) 2021-10-20 2022-10-20 抗ガン剤、抗ガン剤のプロドラッグ、体外でガン細胞を死滅させる方法、ガンの治療方法、及びガンの治療装置

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CN118159293A true CN118159293A (zh) 2024-06-07

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CN202280070780.XA Pending CN118159293A (zh) 2021-10-20 2022-10-20 抗癌药、抗癌药的前药、在体外杀灭癌细胞的方法、癌症的治疗方法、以及癌症的治疗装置

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US (1) US20240424103A1 (https=)
EP (1) EP4420678A4 (https=)
JP (1) JP7455316B2 (https=)
CN (1) CN118159293A (https=)
WO (1) WO2023068325A1 (https=)

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JPS59203663A (ja) 1983-05-02 1984-11-17 Matsushita Electric Ind Co Ltd 霧化装置
JPH1112197A (ja) * 1997-06-18 1999-01-19 Cosmo Sogo Kenkyusho:Kk 悪性腫瘍診断剤及び治療剤
JP2003096098A (ja) * 2001-09-25 2003-04-03 Nippon Sanso Corp 安定同位体標識抗体及びその製造方法ならびにこれを用いた検出方法
JP4520219B2 (ja) 2004-05-28 2010-08-04 協和発酵バイオ株式会社 ５−アミノレブリン酸の製造法
JP4750638B2 (ja) * 2006-07-19 2011-08-17 独立行政法人 日本原子力研究開発機構 粒子線治療装置
JP5392752B2 (ja) 2009-02-18 2014-01-22 独立行政法人産業技術総合研究所 超低炭素ステンレス鋼製フランジおよび継ぎ手並びに超低炭素ステンレス鋼製封止用弁
JP6234064B2 (ja) * 2012-05-23 2017-11-22 キヤノン株式会社 重合体、前記重合体を用いた核磁気共鳴分析用または磁気共鳴イメージング用の造影剤、化合物、前記重合体を用いた核磁気共鳴分析方法および磁気共鳴イメージング方法
JP2014177421A (ja) * 2013-03-14 2014-09-25 Univ Of Fukui 陽子線治療用増感剤、及びそれを用いた陽子線治療法
JP2016216404A (ja) * 2015-05-22 2016-12-22 国立大学法人北海道大学 陽子線治療用増感剤および陽子線治療方法
US10314551B2 (en) * 2015-06-16 2019-06-11 The Trustees Of Princeton University Detector, three-dimensional direct positron imaging unit, and method to estimate the differential of the radiation dose provided to cancer cells and healthy tissues during hadrotherapy
US10821191B2 (en) * 2015-09-22 2020-11-03 Byondis B.V. SYD985 treatment of T-DM1 refractory cancer patients
EP3266470A1 (en) * 2016-07-06 2018-01-10 Fyzikální ústav AV CR, v.v.i. Device and method for imaging and enhanced proton-therapy treatment using nuclear reactions
WO2018025168A1 (en) * 2016-08-03 2018-02-08 Pfizer Inc. Heteroaryl sulfone-based conjugation handles, methods for their preparation, and their use in synthesizing antibody drug conjugates
EP3641783A4 (en) * 2017-06-22 2021-03-10 University Of Virginia Patent Foundation Proton activated atomic medicine
US11771779B2 (en) * 2018-01-26 2023-10-03 Hadasit Medical Research Services & Development Limited Non-metallic magnetic resonance contrast agent
CN114207127B (zh) * 2019-08-09 2024-11-29 国立研究开发法人产业技术综合研究所 人工基因和基因变异方法
CN112834680B (zh) * 2020-12-31 2023-03-03 苏州海科医药技术有限公司 一种测定肿瘤患者血浆中替加氟、吉美嘧啶和5-氟尿嘧啶浓度的方法

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EP4420678A4 (en) 2025-12-24
US20240424103A1 (en) 2024-12-26
EP4420678A1 (en) 2024-08-28
JPWO2023068325A1 (https=) 2023-04-27
JP7455316B2 (ja) 2024-03-26
WO2023068325A1 (ja) 2023-04-27

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