CN118119642A - 工程化Fc变体 - Google Patents

工程化Fc变体 Download PDF

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Publication number
CN118119642A
CN118119642A CN202280070334.9A CN202280070334A CN118119642A CN 118119642 A CN118119642 A CN 118119642A CN 202280070334 A CN202280070334 A CN 202280070334A CN 118119642 A CN118119642 A CN 118119642A
Authority
CN
China
Prior art keywords
fragment
engineered
amino acid
engineered immunoglobulin
antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202280070334.9A
Other languages
English (en)
Chinese (zh)
Inventor
J·C·P·古约
S·伊里加拉
D·什凯格罗
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of CN118119642A publication Critical patent/CN118119642A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN202280070334.9A 2021-10-28 2022-10-27 工程化Fc变体 Pending CN118119642A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163272955P 2021-10-28 2021-10-28
US63/272,955 2021-10-28
PCT/IB2022/060324 WO2023073599A1 (en) 2021-10-28 2022-10-27 Engineered fc variants

Publications (1)

Publication Number Publication Date
CN118119642A true CN118119642A (zh) 2024-05-31

Family

ID=84366307

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202280070334.9A Pending CN118119642A (zh) 2021-10-28 2022-10-27 工程化Fc变体

Country Status (5)

Country Link
US (1) US20250011428A1 (https=)
EP (1) EP4423123A1 (https=)
JP (1) JP2024541905A (https=)
CN (1) CN118119642A (https=)
WO (1) WO2023073599A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN120718139A (zh) * 2025-08-14 2025-09-30 成都蓉生药业有限责任公司 一种免疫球蛋白Fc变体、基因、表达载体、宿主细胞、多肽、抗体、融合蛋白药物及其应用
WO2026014615A1 (ko) * 2024-07-10 2026-01-15 고려대학교 산학협력단 작용기 기능이 제거된 신규 당화 fc 변이체

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20250065477A (ko) * 2023-11-03 2025-05-13 고려대학교 산학협력단 작용기 기능이 제거된 Fab-arm 교환 방지 Fc 변이체들

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2026014615A1 (ko) * 2024-07-10 2026-01-15 고려대학교 산학협력단 작용기 기능이 제거된 신규 당화 fc 변이체
CN120718139A (zh) * 2025-08-14 2025-09-30 成都蓉生药业有限责任公司 一种免疫球蛋白Fc变体、基因、表达载体、宿主细胞、多肽、抗体、融合蛋白药物及其应用

Also Published As

Publication number Publication date
EP4423123A1 (en) 2024-09-04
WO2023073599A1 (en) 2023-05-04
JP2024541905A (ja) 2024-11-13
US20250011428A1 (en) 2025-01-09

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