CN118021770A - 软性抗胆碱能酯的方法和组合物 - Google Patents
软性抗胆碱能酯的方法和组合物 Download PDFInfo
- Publication number
- CN118021770A CN118021770A CN202410181298.4A CN202410181298A CN118021770A CN 118021770 A CN118021770 A CN 118021770A CN 202410181298 A CN202410181298 A CN 202410181298A CN 118021770 A CN118021770 A CN 118021770A
- Authority
- CN
- China
- Prior art keywords
- hydroxyacetoxy
- cyclopentyl
- phenyl
- methylpyrrolidinium bromide
- cyclodextrin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Inorganic Chemistry (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562217362P | 2015-09-11 | 2015-09-11 | |
| US62/217,362 | 2015-09-11 | ||
| CN201680065967.5A CN108348502A (zh) | 2015-09-11 | 2016-09-06 | 软性抗胆碱能酯的方法和组合物 |
| PCT/US2016/050385 WO2017044412A1 (en) | 2015-09-11 | 2016-09-06 | Methods and compositions for soft anticholinergic esters |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680065967.5A Division CN108348502A (zh) | 2015-09-11 | 2016-09-06 | 软性抗胆碱能酯的方法和组合物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN118021770A true CN118021770A (zh) | 2024-05-14 |
Family
ID=58239861
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202410181298.4A Pending CN118021770A (zh) | 2015-09-11 | 2016-09-06 | 软性抗胆碱能酯的方法和组合物 |
| CN202410181300.8A Pending CN118021797A (zh) | 2015-09-11 | 2016-09-06 | 软性抗胆碱能酯的方法和组合物 |
| CN202410181296.5A Pending CN118045082A (zh) | 2015-09-11 | 2016-09-06 | 软性抗胆碱能酯的方法和组合物 |
| CN201680065967.5A Pending CN108348502A (zh) | 2015-09-11 | 2016-09-06 | 软性抗胆碱能酯的方法和组合物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202410181300.8A Pending CN118021797A (zh) | 2015-09-11 | 2016-09-06 | 软性抗胆碱能酯的方法和组合物 |
| CN202410181296.5A Pending CN118045082A (zh) | 2015-09-11 | 2016-09-06 | 软性抗胆碱能酯的方法和组合物 |
| CN201680065967.5A Pending CN108348502A (zh) | 2015-09-11 | 2016-09-06 | 软性抗胆碱能酯的方法和组合物 |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US11534422B2 (https=) |
| EP (1) | EP3347007B1 (https=) |
| JP (4) | JP7270958B2 (https=) |
| KR (1) | KR102889909B1 (https=) |
| CN (4) | CN118021770A (https=) |
| AU (2) | AU2016318595B2 (https=) |
| ES (1) | ES2942361T3 (https=) |
| IL (1) | IL257970B (https=) |
| MX (1) | MX388831B (https=) |
| MY (1) | MY197265A (https=) |
| WO (1) | WO2017044412A1 (https=) |
| ZA (1) | ZA201801685B (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109044965A (zh) * | 2018-10-17 | 2018-12-21 | 广州大光制药有限公司 | 格隆溴铵的眼用药物组合物及医药用途 |
| CA3174550A1 (en) * | 2020-03-03 | 2021-09-10 | Kaken Pharmaceutical Co., Ltd. | Medicament containing sofpironium bromide |
| KR20240088983A (ko) | 2021-11-01 | 2024-06-20 | 유타대학연구재단 | 침흘림증 치료를 위한 조성물 및 방법 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2879100A (en) | 1999-02-12 | 2000-08-29 | Miles A. Libbey Iii | Formulation and system for intra-oral delivery of pharmaceutical agents |
| WO2001008681A1 (en) | 1999-08-02 | 2001-02-08 | First Horizon Pharmaceutical Corporation | Methods of administration of glycopyrrolate compositions |
| US9198897B2 (en) | 2005-01-19 | 2015-12-01 | Neurohealing Pharmaceuticals, Inc. | Methods and compositions for decreasing saliva production |
| US7417147B2 (en) | 2005-11-10 | 2008-08-26 | Bodor Nicholas S | Soft anticholinergic zwitterions |
| ATE529399T1 (de) | 2005-11-10 | 2011-11-15 | Nicholas S Bodor | Sanfte anticholinerge ester |
| US8071693B2 (en) | 2006-06-22 | 2011-12-06 | Sabic Innovative Plastics Ip B.V. | Polysiloxane/polyimide copolymers and blends thereof |
| US20080260823A1 (en) * | 2007-04-20 | 2008-10-23 | Sciele Pharma, Inc. | Orally disintegrating tablet comprising glycopyrrolate for treating sialorrhea |
| AU2008268465A1 (en) | 2007-06-22 | 2008-12-31 | Sciele Pharma, Inc. | Transdermal delivery system comprising glycopyrrolate to treat sialorrhea |
| CN102016595B (zh) | 2008-03-27 | 2014-08-06 | 哈佛学院院长等 | 三维微流体装置 |
| KR102241660B1 (ko) | 2013-03-15 | 2021-04-19 | 보도르 라보래토리즈, 인크. | 다한증 치료용 항콜린성 글리코피롤레이트 에스테르 |
-
2016
- 2016-09-06 ES ES16844930T patent/ES2942361T3/es active Active
- 2016-09-06 US US15/758,190 patent/US11534422B2/en active Active
- 2016-09-06 JP JP2018513004A patent/JP7270958B2/ja active Active
- 2016-09-06 WO PCT/US2016/050385 patent/WO2017044412A1/en not_active Ceased
- 2016-09-06 MY MYPI2018700940A patent/MY197265A/en unknown
- 2016-09-06 CN CN202410181298.4A patent/CN118021770A/zh active Pending
- 2016-09-06 EP EP16844930.4A patent/EP3347007B1/en active Active
- 2016-09-06 CN CN202410181300.8A patent/CN118021797A/zh active Pending
- 2016-09-06 CN CN202410181296.5A patent/CN118045082A/zh active Pending
- 2016-09-06 AU AU2016318595A patent/AU2016318595B2/en active Active
- 2016-09-06 CN CN201680065967.5A patent/CN108348502A/zh active Pending
- 2016-09-06 MX MX2018003002A patent/MX388831B/es unknown
- 2016-09-06 KR KR1020187009786A patent/KR102889909B1/ko active Active
-
2018
- 2018-03-08 IL IL257970A patent/IL257970B/en active IP Right Grant
- 2018-03-12 ZA ZA2018/01685A patent/ZA201801685B/en unknown
-
2020
- 2020-10-12 JP JP2020171891A patent/JP2021001238A/ja not_active Withdrawn
-
2021
- 2021-06-24 AU AU2021204306A patent/AU2021204306B2/en active Active
-
2022
- 2022-06-23 US US17/848,386 patent/US11951093B2/en active Active
- 2022-07-14 JP JP2022113088A patent/JP7723417B2/ja active Active
-
2023
- 2023-09-20 JP JP2023154001A patent/JP2023164671A/ja active Pending
-
2024
- 2024-03-08 US US18/600,632 patent/US12458625B2/en active Active
-
2025
- 2025-10-23 US US19/367,341 patent/US20260108491A1/en active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| REG | Reference to a national code |
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