JP7270958B2 - 低中毒性抗コリン作動性エステルのための方法および組成物 - Google Patents

低中毒性抗コリン作動性エステルのための方法および組成物 Download PDF

Info

Publication number
JP7270958B2
JP7270958B2 JP2018513004A JP2018513004A JP7270958B2 JP 7270958 B2 JP7270958 B2 JP 7270958B2 JP 2018513004 A JP2018513004 A JP 2018513004A JP 2018513004 A JP2018513004 A JP 2018513004A JP 7270958 B2 JP7270958 B2 JP 7270958B2
Authority
JP
Japan
Prior art keywords
hydroxyacetoxy
cyclopentyl
phenyl
methylpyrrolidinium bromide
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2018513004A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018526420A (ja
JP2018526420A5 (https=
Inventor
ニコラス エス． ボドール，
Original Assignee
ボドール ラボラトリーズ， インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ボドール ラボラトリーズ， インコーポレイテッド filed Critical ボドール ラボラトリーズ， インコーポレイテッド
Publication of JP2018526420A publication Critical patent/JP2018526420A/ja
Publication of JP2018526420A5 publication Critical patent/JP2018526420A5/ja
Application granted granted Critical
Publication of JP7270958B2 publication Critical patent/JP7270958B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Inorganic Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2018513004A 2015-09-11 2016-09-06 低中毒性抗コリン作動性エステルのための方法および組成物 Active JP7270958B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562217362P 2015-09-11 2015-09-11
US62/217,362 2015-09-11
PCT/US2016/050385 WO2017044412A1 (en) 2015-09-11 2016-09-06 Methods and compositions for soft anticholinergic esters

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020171891A Division JP2021001238A (ja) 2015-09-11 2020-10-12 低中毒性抗コリン作動性エステルのための方法および組成物

Publications (3)

Publication Number Publication Date
JP2018526420A JP2018526420A (ja) 2018-09-13
JP2018526420A5 JP2018526420A5 (https=) 2019-10-10
JP7270958B2 true JP7270958B2 (ja) 2023-05-11

Family

ID=58239861

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2018513004A Active JP7270958B2 (ja) 2015-09-11 2016-09-06 低中毒性抗コリン作動性エステルのための方法および組成物
JP2020171891A Withdrawn JP2021001238A (ja) 2015-09-11 2020-10-12 低中毒性抗コリン作動性エステルのための方法および組成物
JP2022113088A Active JP7723417B2 (ja) 2015-09-11 2022-07-14 低中毒性抗コリン作動性エステルのための方法および組成物
JP2023154001A Pending JP2023164671A (ja) 2015-09-11 2023-09-20 低中毒性抗コリン作動性エステルのための方法および組成物

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2020171891A Withdrawn JP2021001238A (ja) 2015-09-11 2020-10-12 低中毒性抗コリン作動性エステルのための方法および組成物
JP2022113088A Active JP7723417B2 (ja) 2015-09-11 2022-07-14 低中毒性抗コリン作動性エステルのための方法および組成物
JP2023154001A Pending JP2023164671A (ja) 2015-09-11 2023-09-20 低中毒性抗コリン作動性エステルのための方法および組成物

Country Status (12)

Country Link
US (4) US11534422B2 (https=)
EP (1) EP3347007B1 (https=)
JP (4) JP7270958B2 (https=)
KR (1) KR102889909B1 (https=)
CN (4) CN118021770A (https=)
AU (2) AU2016318595B2 (https=)
ES (1) ES2942361T3 (https=)
IL (1) IL257970B (https=)
MX (1) MX388831B (https=)
MY (1) MY197265A (https=)
WO (1) WO2017044412A1 (https=)
ZA (1) ZA201801685B (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109044965A (zh) * 2018-10-17 2018-12-21 广州大光制药有限公司 格隆溴铵的眼用药物组合物及医药用途
CA3174550A1 (en) * 2020-03-03 2021-09-10 Kaken Pharmaceutical Co., Ltd. Medicament containing sofpironium bromide
KR20240088983A (ko) 2021-11-01 2024-06-20 유타대학연구재단 침흘림증 치료를 위한 조성물 및 방법

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020055496A1 (en) 1999-02-12 2002-05-09 Mccoy Randall Formulation and system for intra-oral delivery of pharmaceutical agents
US20080260823A1 (en) 2007-04-20 2008-10-23 Sciele Pharma, Inc. Orally disintegrating tablet comprising glycopyrrolate for treating sialorrhea

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001008681A1 (en) 1999-08-02 2001-02-08 First Horizon Pharmaceutical Corporation Methods of administration of glycopyrrolate compositions
US9198897B2 (en) 2005-01-19 2015-12-01 Neurohealing Pharmaceuticals, Inc. Methods and compositions for decreasing saliva production
US7417147B2 (en) 2005-11-10 2008-08-26 Bodor Nicholas S Soft anticholinergic zwitterions
ATE529399T1 (de) 2005-11-10 2011-11-15 Nicholas S Bodor Sanfte anticholinerge ester
US8071693B2 (en) 2006-06-22 2011-12-06 Sabic Innovative Plastics Ip B.V. Polysiloxane/polyimide copolymers and blends thereof
AU2008268465A1 (en) 2007-06-22 2008-12-31 Sciele Pharma, Inc. Transdermal delivery system comprising glycopyrrolate to treat sialorrhea
CN102016595B (zh) 2008-03-27 2014-08-06 哈佛学院院长等 三维微流体装置
KR102241660B1 (ko) 2013-03-15 2021-04-19 보도르 라보래토리즈, 인크. 다한증 치료용 항콜린성 글리코피롤레이트 에스테르

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020055496A1 (en) 1999-02-12 2002-05-09 Mccoy Randall Formulation and system for intra-oral delivery of pharmaceutical agents
US20080260823A1 (en) 2007-04-20 2008-10-23 Sciele Pharma, Inc. Orally disintegrating tablet comprising glycopyrrolate for treating sialorrhea

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ＪＯＵＲＮＡＬ ＯＦ ＰＨＡＲＭＡＣＹ ＡＮＤ ＰＨＡＲＭＡＣＯＬＯＧＹ，２００５年，Ｖ５７ Ｎ１１，Ｐ１４２７－１４３５

Also Published As

Publication number Publication date
US20260108491A1 (en) 2026-04-23
IL257970A (en) 2018-05-31
US11534422B2 (en) 2022-12-27
CN118021770A (zh) 2024-05-14
JP2018526420A (ja) 2018-09-13
EP3347007B1 (en) 2023-03-29
KR20180061220A (ko) 2018-06-07
US12458625B2 (en) 2025-11-04
JP2023164671A (ja) 2023-11-10
IL257970B (en) 2021-04-29
JP2021001238A (ja) 2021-01-07
MY197265A (en) 2023-06-08
KR102889909B1 (ko) 2025-11-24
CN118021797A (zh) 2024-05-14
CA2998357A1 (en) 2017-03-16
US20180250265A1 (en) 2018-09-06
ZA201801685B (en) 2023-12-20
EP3347007A4 (en) 2019-05-08
CN118045082A (zh) 2024-05-17
MX2018003002A (es) 2018-08-01
AU2021204306A1 (en) 2021-07-22
JP7723417B2 (ja) 2025-08-14
CN108348502A (zh) 2018-07-31
MX388831B (es) 2025-03-20
EP3347007A1 (en) 2018-07-18
AU2016318595B2 (en) 2021-07-08
US20220401410A1 (en) 2022-12-22
ES2942361T3 (es) 2023-05-31
AU2021204306B2 (en) 2023-11-09
US20240261262A1 (en) 2024-08-08
US11951093B2 (en) 2024-04-09
AU2016318595A1 (en) 2018-04-26
WO2017044412A1 (en) 2017-03-16
JP2022132446A (ja) 2022-09-08
HK1255558A1 (en) 2019-08-23

Similar Documents

Publication Publication Date Title
JP5941558B2 (ja) シルデナフィルを有効成分として含有し、且つ、苦味の隠蔽された高含量速溶フィルム
KR101720546B1 (ko) 구강 삽입용 투여 제형
US12458625B2 (en) Methods and compositions for soft anticholinergic esters
JP2000063268A (ja) 口腔粘膜付着型徐放性錠剤及び歯周疾患治療剤
JP2000178185A (ja) 口腔粘膜付着型徐放性錠剤
CA2998357C (en) Compositions comprising a soft anticholinergic ester
WO2017044411A1 (en) Methods and compositions for soft anticholinergic zwitterions
HK40110881A (zh) 软性抗胆碱能酯的方法和组合物
HK40110882A (zh) 软性抗胆碱能酯的方法和组合物
HK40111398A (zh) 软性抗胆碱能酯的方法和组合物
HK1255558B (en) Methods and compositions for soft anticholinergic esters
JP2001002590A (ja) 口腔粘膜付着型徐放性錠剤
KR101440808B1 (ko) 실데나필 또는 이의 약제학적으로 허용되는 염을 고함량으로 포함하는 속용필름

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20190829

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20190829

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20200630

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20200929

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20210212

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210611

C60 Trial request (containing other claim documents, opposition documents)

Free format text: JAPANESE INTERMEDIATE CODE: C60

Effective date: 20210611

C11 Written invitation by the commissioner to file amendments

Free format text: JAPANESE INTERMEDIATE CODE: C11

Effective date: 20210623

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20210802

C21 Notice of transfer of a case for reconsideration by examiners before appeal proceedings

Free format text: JAPANESE INTERMEDIATE CODE: C21

Effective date: 20210803

A912 Re-examination (zenchi) completed and case transferred to appeal board

Free format text: JAPANESE INTERMEDIATE CODE: A912

Effective date: 20210910

C211 Notice of termination of reconsideration by examiners before appeal proceedings

Free format text: JAPANESE INTERMEDIATE CODE: C211

Effective date: 20210914

C22 Notice of designation (change) of administrative judge

Free format text: JAPANESE INTERMEDIATE CODE: C22

Effective date: 20220929

C13 Notice of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: C13

Effective date: 20221104

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20230206

C23 Notice of termination of proceedings

Free format text: JAPANESE INTERMEDIATE CODE: C23

Effective date: 20230301

C03 Trial/appeal decision taken

Free format text: JAPANESE INTERMEDIATE CODE: C03

Effective date: 20230327

C30A Notification sent

Free format text: JAPANESE INTERMEDIATE CODE: C3012

Effective date: 20230327

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20230419

R150 Certificate of patent or registration of utility model

Ref document number: 7270958

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250