CN118021675A - Sun-proof synergistic composition and preparation method and application thereof - Google Patents
Sun-proof synergistic composition and preparation method and application thereof Download PDFInfo
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- CN118021675A CN118021675A CN202410128208.5A CN202410128208A CN118021675A CN 118021675 A CN118021675 A CN 118021675A CN 202410128208 A CN202410128208 A CN 202410128208A CN 118021675 A CN118021675 A CN 118021675A
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- sun
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- sunscreen
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- 230000002195 synergetic effect Effects 0.000 title claims abstract description 59
- 239000000203 mixture Substances 0.000 title claims abstract description 53
- 238000002360 preparation method Methods 0.000 title abstract description 10
- 239000000516 sunscreening agent Substances 0.000 claims abstract description 67
- 230000000475 sunscreen effect Effects 0.000 claims abstract description 43
- 239000000126 substance Substances 0.000 claims abstract description 37
- -1 glucosyl rutin Chemical compound 0.000 claims abstract description 29
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 claims abstract description 26
- BNMGUJRJUUDLHW-HCZMHFOYSA-N Madecassoside Chemical compound O([C@@H]1[C@@H](CO)O[C@H]([C@@H]([C@H]1O)O)OC[C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)OC(=O)[C@]12CC[C@H]([C@@H]([C@H]1C=1[C@@]([C@@]3(C[C@@H](O)[C@H]4[C@](C)(CO)[C@@H](O)[C@H](O)C[C@]4(C)[C@H]3CC=1)C)(C)CC2)C)C)[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O BNMGUJRJUUDLHW-HCZMHFOYSA-N 0.000 claims abstract description 26
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Landscapes
- Cosmetics (AREA)
Abstract
The application relates to the technical field of cosmetics, and particularly discloses a sun-proof synergistic composition, a preparation method and application thereof. A synergistic composition for preventing and treating sunscreens contains chemical sunscreen agent (5.5-8.5%), bisabolol (0.3-1%), glucosyl rutin (0.5-1%), madecassoside (0.5-2%), flower/leaf/stem extract of Scutellaria baicalensis (0.5-1%), etc. A preparation method of the sun-proof synergistic composition comprises the step of uniformly mixing all the components to obtain the sun-proof synergistic composition. The application also provides an application of the synergistic composition based on the sun protection in sun protection products. The sun-proof synergistic composition can obviously reduce the irritation of chemical sun-proof agents, has the effects of resisting inflammation and relieving allergy, can reduce the damage of ultraviolet rays to skin, reduces the generation of erythema, and can also obviously improve the SPF value of sun-proof agent combination.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to a sun-proof synergistic composition, a preparation method and application thereof.
Background
Ultraviolet rays have strong injury effect on skin, and are easy to cause rough skin, blacken skin, allergic skin and even photosensitive reaction, so that the skin has symptoms of redness, swelling, pain, itching and the like. Therefore, it is necessary to make suncare in daily life.
Traditional sun-screening products usually only pay attention to a single sun-screening effect, because the chemical sun-screening agent has certain irritation to skin, the chemical sun-screening agent cannot be added at the same time when the SPF value of the sun-screening product is to be increased, and the physical sun-screening agent and the chemical sun-screening agent are usually used cooperatively to increase the SPF value of the sun-screening product in the market, so that the dosage of the chemical sun-screening agent can be reduced, and the irritation of the chemical sun-screening agent to the skin can be reduced. However, physical sunscreens generally remain on the surface of the skin, causing the skin to become dead white, making the makeup very unnatural, and at the same time, blocking pores and dry skin feel.
Therefore, there is a need to further improve the formulation of sun protection products so that the sun protection products not only improve the sun protection effect, but also reduce the amount of sun protection agents used.
Disclosure of Invention
In order to further improve the formula of the sun-screening product, so that the sun-screening product not only can improve sun-screening effect, but also can reduce the dosage of sun-screening agent, the application provides a sun-screening synergistic composition, a preparation method and application thereof. The application discovers that the bisabolol, glucosyl rutin, madecassoside and the flower/leaf/stem extract of the scutellaria baicalensis have good synergistic effect, can obviously reduce the irritation of chemical sunscreens, has the effects of anti-inflammatory and allergy-relieving, can reduce the damage of ultraviolet rays to skin, reduces the generation of erythema, and can also obviously improve the SPF value of the sunscreen composition.
In a first aspect, the application provides a sunscreen synergistic composition, which adopts the following technical scheme:
A sun-proof synergistic composition comprises the following components in percentage by mass: 1% -5% of humectant, 0.02% -0.05% of chelating agent, 2% -3% of emulsifying agent, 5% -9% of emollient, 5.5% -8.5% of chemical sun-screening agent, 0.1% -0.5% of preservative, 0.3% -1% of bisabolol, 0.5% -1% of glucosyl rutin, 0.5% -2% of madecassoside, 0.5% -1% of scutellaria baicalensis flower/leaf/stem extract and the balance of water.
According to the technical scheme, the red medicine alcohol has the effects of moisturizing, resisting inflammation and relieving skin, so that the irritation of ultraviolet rays to the skin can be reduced, and the comfort level of a sun-screening product is improved; glucosyl rutin has very strong absorption effect on ultraviolet rays, and simultaneously has good anti-inflammatory and antioxidant effects; madecassoside has anti-inflammatory, antiallergic, skin soothing effects, and improves the comfort of sunscreen products; the flower/leaf/stem extract of Scutellaria baicalensis Georgi is rich in various active ingredients, has good anti-inflammatory and antioxidant effects, and can also enhance skin resistance and reduce skin injury caused by ultraviolet rays.
The four skin conditioning agents including the bisabolol, the glucosyl rutin, the madecassoside and the flower/leaf/stem extract of the scutellaria baicalensis are added into the sun-proof product, so that the irritation of the chemical sun-proof agent can be obviously reduced, the comfort of the sun-proof product is improved, the unexpected sun-proof synergistic effect on the sun-proof product is achieved, the effective ultraviolet-isolation time of the sun-proof product is further prolonged, the SPF value of the sun-proof product is further improved, and the defect that the sun-proof product is frequently coated after the sun-proof product is coated on the surface layer of the skin is overcome. Specifically, the bisabolol, glucosyl rutin, madecassoside and the flower/leaf/stem extract of scutellaria baicalensis can synergistically improve the photostability and waterproofness of the chemical sunscreen agent and the oxidation resistance of the sunscreen product, and further perform the sun-screening synergistic effect on the sunscreen product.
Preferably, the mass ratio of the bisabolol, the glucosyl rutin, the madecassoside and the scutellaria baicalensis flowers/leaves/stems extract is (0.5-0.6): (0.5-0.6): (0.5-1): (0.8-1).
In the technical scheme, the application further plays a better sun-proof synergistic effect and further improves the water resistance of sun-proof products by further limiting the mass ratio of the bisabolol, the glucosyl rutin, the madecassoside and the flower/leaf/stem extracts of the scutellaria baicalensis.
Preferably, the sunscreen synergistic composition further comprises 0.2% -0.8% stearyl glycyrrhetinate, based on the mass percentage of the sunscreen synergistic composition.
According to the technical scheme, the stearyl glycyrrhetinate skin conditioner is further added, so that the stearyl glycyrrhetinate has the effects of resisting inflammation and allergy and relieving skin, and the comfort level of a sun-screening product can be improved.
According to the sun-proof synergistic composition provided by the application, the stearyl glycyrrhetinate and the bisabolol, glucosyl rutin, madecassoside and the scutellaria baicalensis flower/leaf/stem extracts are matched in a synergistic way, so that the photostability of a chemical sun-proof agent can be further improved, the oxidation resistance of sun-proof products is improved, the sun-proof synergistic effect is further achieved, meanwhile, the water resistance of the sun-proof products can be further remarkably improved, the sun-proof products have better water resistance and are not easy to be washed by water flow, and the problem that the sun-proof products fall off due to excessive sweating in hot summer can be solved.
Preferably, the mass ratio of the bisabolol, the glucosyl rutin, the madecassoside, the scutellaria baicalensis flower/leaf/stem extract and the stearyl glycyrrhetinate is (0.5-0.6): (0.5-0.6): (0.5-1): (0.8-1): (0.5-0.6).
According to the technical scheme, the mass ratio of the bisabolol, the glucosyl rutin, the madecassoside, the scutellaria baicalensis flower/leaf/stem extract and the stearyl glycyrrhetinate is further limited, so that the five components can be better cooperated, the irritation of a sun-proof product is further reduced, the better sun-proof synergy is exerted, and the waterproofness of the sun-proof product is further improved.
Preferably, the emulsifier may be glycerol stearate, PEG-100 stearate, cetostearyl olivate, sorbitan olivate, glycerol stearate citrate, C12-20 alkyl glucoside, cetostearyl glucoside, methyl glucose sesquistearate, PEG-20 methyl glucose sesquistearate, cetostearyl polyether-25, and the like.
Preferably, the emollient may be caprylic/capric triglyceride, C12-15 alcohol benzoate, polydimethylsiloxane, phenyl trimethicone, octyl polymethylsiloxane, ethylhexyl hydroxystearate, butylene glycol dicaprylate/dicaprate, jojoba seed oil, squalane, diphenylsiloxyphenyl trimethicone, tri (ethylhexanoate), octyl dodecanol, diisostearyl malate, cetyl ethylhexanoate, and the like.
Preferably, the chemical sunscreen may be ethylhexyl methoxycinnamate, butylmethoxydibenzoylmethane, octocrylene, methylenebis-benzotriazole tetramethylbutylphenol, bis-ethylhexyloxyphenol methoxyphenyl triazine, hexyl diethylcarbamoylbenzoate, ethylhexyl triazone, phenylbenzimidazole sulfonic acid, ethylhexyl salicylate, homosalate, and the like.
Preferably, the chemical sunscreen is a combination of octyl methoxycinnamate, butyl methoxydibenzoylmethane.
In the technical scheme, the butyl methoxy dibenzoylmethane has good light stability to skin, can absorb ultraviolet rays of 290-320nm, is an efficient UVA and UVB absorber, can obviously improve the SPF value and the PA value of a sun-screening product, prolongs the effective ultraviolet ray isolation time of the sun-screening product, and the octyl methoxycinnamate serving as a chemical sun-screening agent has good light stability to skin, can absorb ultraviolet rays of 290-360nm, is an efficient UVB absorber, can obviously improve the SPF value and the PA value of the sun-screening product, and prolongs the effective ultraviolet ray isolation time of the sun-screening product. By compounding octyl methoxycinnamate, butyl methoxydibenzoylmethane, bisabolol, glucosyl rutin, madecassoside, flos scutellariae sinensis/leaf/stem extract, stearyl glycyrrhetinate, the irritation of the sun-screening product can be further reduced and the SPF value of the sun-screening product can be improved,
In a second aspect, the application provides a preparation method of a sun-proof synergistic composition, which adopts the following technical scheme:
a method for preparing a sun-proof synergistic composition, which is characterized by comprising the following steps:
step one: uniformly mixing humectant, chelating agent, emulsifier, emollient and water at 80-82 ℃;
step two: adding a chemical sun-screening agent into the solution obtained in the step one, uniformly mixing, and preserving heat for 30-40 min;
Step three: cooling to below 40 ℃, adding the rest components while stirring, and uniformly mixing to obtain the sun-proof synergistic composition.
Preferably, the mixing condition in the first step is stirring at 20-30Hz for 5-8min, and the mixing condition in the second step is stirring at 20-30Hz for 3-5min.
In the technical scheme, in the first step, the humectant, the chelating agent, the emulsifier, the emollient and the water are uniformly mixed, and the components interact in the mixing process, so that better stability can be provided for the chemical sun-screening agent added later; in the second step, the chemical sun-screening agent is added into the solution obtained in the first step, and the temperature is kept for 30-40 min, so that the chemical sun-screening agent can fully react with other components, and the stability of the chemical sun-screening agent is further improved. The preparation method provided by the application is simple to operate and easy for industrial production. The preparation method provided by the application can conveniently and rapidly prepare the sun-proof product with excellent sun-proof effect and comfort level, and meets the requirements of consumers on the sun-proof product.
In a third aspect, the application provides a sunscreen synergistic composition, which is applied to a sunscreen product by adopting the following technical scheme:
use of a sunscreen synergistic composition according to the first aspect in a sunscreen product.
In the technical scheme, the sun-proof synergistic composition has double effects, and has a good skin care effect and further improves the sun-proof effect of sun-proof products through skin conditioning agents such as bisabolol, glucosyl rutin, madecassoside, scutellaria baicalensis flower/leaf/stem extracts and the like. The sun-proof synergistic composition can be used as a sun-proof product alone or added into other sun-proof products to be used as a synergistic agent, and can improve sun-proof effect of the sun-proof product while reducing irritation of the sun-proof product. In addition, the sunscreen synergistic composition of the present application may be incorporated into any of the oil-in-water, water-in-oil, all-water or all-oil phase base sunscreen products.
The application has the following beneficial technical effects:
The application discovers in the research that the combination of four skin conditioning agents of bisabolol, glucosyl rutin, madecassoside and scutellaria baicalensis flowers/leaves/stems extract not only has better anti-inflammatory and allergy-relieving effects and ultraviolet injury isolating effects, but also has unexpected synergistic effects of improving the photostability and waterproofness of chemical sunscreens and improving the oxidation resistance of sun-screening products, thereby achieving further sun-screening and synergy effects. The stearyl glycyrrhetinate is further added into the extracts of bisabolol, glucosyl rutin, madecassoside and flowers/leaves/stems of scutellaria baicalensis, so that the photostability of the chemical sun-screening agent can be better improved, the oxidation resistance of the sun-screening product can be improved, and the water resistance of the sun-screening product can be obviously improved.
Detailed Description
For a better description of the objects, technical solutions and advantages of the present invention, the present invention will be further described with reference to the following specific examples.
The sources of some of the substances appearing in the following embodiments are shown in Table 1.
Table 1:
Example 1
A sunscreen synergistic composition comprising the following components:
Water, moisturizer, chelator, emulsifier, emollient, chemical sunscreen, preservative, bisabolol, glucosyl rutin, madecassoside, extract of flowers/leaves/stems of Scutellaria baicalensis, stearyl glycyrrhetinate.
Wherein the humectant is glycerin.
Wherein the chelating agent is disodium edetate.
Wherein the emulsifier is PEG-100 stearate.
Wherein the emollient is caprylic/capric triglyceride.
Wherein the preservative is phenoxyethanol.
Wherein the chemical sun-screening agent is a combination of butyl methoxy dibenzoylmethane and octyl methoxy cinnamate.
Wherein, the dosage of each substance of the sun-proof synergistic composition is shown in Table 2.
The preparation method of the sun-proof synergistic composition comprises the following steps:
step one: the moisturizer, chelator, emulsifier, emollient and water were stirred at 30Hz for 5min at 80 ℃.
Step two: adding a chemical sun-screening agent into the solution obtained in the step one, stirring for 5min at 20Hz, and preserving the heat for 40min.
Step three: cooling to below 40deg.C, adding the rest components under stirring, and stirring at 30Hz for 3min to obtain the sunscreen synergistic composition.
Example 2
Unlike example 1, the sunscreen synergistic composition was prepared by a process comprising the steps of: step one: the moisturizer, chelator, emulsifier, emollient and water were stirred at 20Hz for 8min at 82 ℃.
Step two: adding a chemical sun-screening agent into the solution obtained in the step one, stirring for 3min at 30Hz, and preserving the heat for 30min.
Step three: cooling to below 40deg.C, adding the rest components under stirring, and stirring at 20Hz for 5min to obtain the sunscreen synergistic composition.
Wherein, the dosage of each substance of the sun-proof synergistic composition is shown in Table 2.
Example 3
Unlike example 1, the sunscreen synergistic composition was prepared by a process comprising the steps of: step one: the moisturizer, chelator, emulsifier, emollient and water were stirred at 25Hz for 6min at 81 ℃.
Step two: adding a chemical sun-screening agent into the solution obtained in the step one, stirring for 4min at25 Hz, and preserving the heat for 32min.
Step three: cooling to below 40deg.C, adding the rest components under stirring, and stirring at 25Hz for 4min to obtain the sunscreen synergistic composition.
Wherein, the dosage of each substance of the sun-proof synergistic composition is shown in Table 2.
Example 4
Unlike example 1, the amounts of the various substances in the sunscreen synergistic composition are shown in Table 2.
Table 2:
Example 5
Unlike example 1, the sunscreen synergistic composition was replaced with equivalent amounts of stearyl glycyrrhetinate as water.
Comparative example 1
Unlike example 5, the sunscreen synergistic composition was replaced with equal amounts of bisabolol as water.
Comparative example 2
Unlike example 5, the glucosyl rutin is replaced with water in equal amount.
Comparative example 3
Unlike example 5, the sunscreen synergistic composition has the equivalent amount of madecassoside replaced with water.
Comparative example 4
Unlike example 5, the sun-protecting synergistic composition was replaced with the extract of flower/leaf/stem of Scutellaria baicalensis Georgi in equal amounts with water.
Comparative example 5
Unlike example 5, the sunscreen synergistic composition was replaced with equal amounts of bisabolol, glucosyl rutin, madecassoside and Scutellaria baicalensis flower/leaf/stem extracts as water.
Comparative example
Unlike example 1, the sun protection product was replaced by equal amounts of bisabolol, glucosyl rutin, madecassoside and extract of flowers/leaves/stems of Scutellaria baicalensis, stearyl glycyrrhetinate, butyl methoxydibenzoylmethane.
Efficacy evaluation
Irritation evaluation:
test sample: the sun protection products of example 1 and comparative example above.
Referring to the skin-sealing patch test of cosmetic hygiene standard 2015, 60 subjects were selected, equally divided into 2 groups, 0.02g of the test sample was taken and placed in a patch tester of the same specification, and the patch tester was fixed to the back of the subject by using an external medical adhesive tape patch. Skin reactions were observed and recorded after 30min, 24h, 48h, respectively.
Wherein, the negative reaction is 0; the suspected reaction was 1; a weak positive response (erythema response) of 2; the strong positive reaction (herpes reaction) was 3; the very strong positive reaction (fusion herpes reaction) was 4.
The detection results are shown in Table 3.
Table 3:
SPF value measurement and Water repellency detection:
test sample: the sun protection products of the above examples and comparative examples and sun protection products of the comparative examples.
SPF value measurement: SPF-290 type sun protection factor analyzer was used to determine the SPF value of the test sample (2 mg/cm 2) coated on the medical breathable tape.
Waterproof performance detection: test samples (2 mg/cm 2) were coated on the medical air-permeable tape, then the medical air-permeable tape was immersed in water for 30s and slowly swung back and forth in water, then the immersed SPF value was measured again, and the change rate (%) was calculated, the change rate= (SPF value-immersed SPF value)/SPF value × 100%.
The results of the above detection are shown in Table 4.
Table 4:
In combination with the analysis of example 5 and comparative examples 1 to 5, comparative examples 1 to 5 were not completely added or not added with bisabolol, glucosyl rutin, madecassoside and Scutellaria baicalensis flower/leaf/stem extracts, whereas example 5 clearly had good SPF value and water resistance, and it was found that only the combination of four skin conditioning agents of bisabolol, glucosyl rutin, madecassoside and Scutellaria baicalensis flower/leaf/stem extracts could exert a sun-screening and synergy effects on sun-screening products.
By combining the analysis of the example 1 and the comparison example, it is easy to see that the example 1 has good mildness and good sun-screening effect, and the inventor analyses that the bisabolol, the glucosyl rutin, the madecassoside, the extract of flowers/leaves/stems of the scutellaria baicalensis and the stearyl glycyrrhetinate have obvious synergistic effect, so that the dosage of the chemical sun-screening agent can be reduced, the cost of the sun-screening product can be reduced, the irritation of the chemical sun-screening agent to skin can be reduced, and the SPF value of the sun-screening product can be further improved.
Analysis in combination with example 1 and example 5, wherein example 5 was not supplemented with stearyl glycyrrhetinate, and analysis in combination with the data of table 4, example 1 was found to have a better sunscreen effect and water repellency, and it was found that further addition of stearyl glycyrrhetinate on the basis of bisabolol, glucosyl rutin, madecassoside, and scutellaria baicalensis flower/leaf/stem extracts was essential for improving the water repellency of sunscreen synergistic compositions.
The present embodiment is only for explanation of the present application and is not to be construed as limiting the present application, and modifications to the present embodiment, which may not creatively contribute to the present application as required by those skilled in the art after reading the present specification, are all protected by patent laws within the scope of claims of the present application.
Claims (8)
1. The sun-proof synergistic composition is characterized by comprising the following components in percentage by mass:
1% -5% of humectant, 0.02% -0.05% of chelating agent, 2% -3% of emulsifying agent, 5% -9% of emollient, 5.5% -8.5% of chemical sun-screening agent, 0.1% -0.5% of preservative, 0.3% -1% of bisabolol, 0.5% -1% of glucosyl rutin, 0.5% -2% of madecassoside, 0.5% -1% of scutellaria baicalensis flower/leaf/stem extract and the balance of water.
2. The synergistic sunscreen composition according to claim 1, wherein the mass ratio of bisabolol, glucosyl rutin, madecassoside and scutellaria baicalensis flowers/leaves/stems extract is (0.5-0.6): (0.5-0.6): (0.5-1): (0.8-1).
3. A sunscreen synergistic composition as claimed in claim 1, wherein the sunscreen synergistic composition further comprises 0.2% to 0.8% stearyl glycyrrhetinate by mass percent of the sunscreen synergistic composition.
4. The synergistic sunscreen composition according to claim 1, wherein the mass ratio of bisabolol, glucosyl rutin, madecassoside, scutellaria baicalensis flower/leaf/stem extract, stearyl glycyrrhetinate is (0.5-0.6): (0.5-0.6): (0.5-1): (0.8-1): (0.5-0.6).
5. A sunscreen synergistic composition as claimed in claim 1, wherein the chemical sunscreen is a combination of octyl methoxycinnamate, butyl methoxydibenzoylmethane.
6. A method for preparing the sun-protection synergistic composition as claimed in any one of claims 1 to 5, comprising the steps of:
Step one: uniformly mixing a humectant, a chelating agent, an emulsifying agent, an emollient and water at the temperature of 80-82 ℃;
step two: adding a chemical sun-screening agent into the solution obtained in the step one, uniformly mixing, and preserving heat for 30-40 min;
Step three: cooling to below 40 ℃, adding the rest components while stirring, and uniformly mixing to obtain the sun-proof synergistic composition.
7. The method for preparing a sunscreen synergistic composition as claimed in claim 6, wherein the mixing condition in the first step is stirring at 20-30Hz for 5-8min, and the mixing condition in the second step is stirring at 20-30Hz for 3-5min.
8. Use of a sunscreen synergistic composition as claimed in any one of claims 1 to 5 in a sunscreen product.
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