CN117979946A - 具有增强的颜色稳定性的化妆品组合物 - Google Patents
具有增强的颜色稳定性的化妆品组合物 Download PDFInfo
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- CN117979946A CN117979946A CN202280044581.1A CN202280044581A CN117979946A CN 117979946 A CN117979946 A CN 117979946A CN 202280044581 A CN202280044581 A CN 202280044581A CN 117979946 A CN117979946 A CN 117979946A
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- cosmetic composition
- resorcinol
- composition
- alkyl
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Abstract
本发明涉及化妆品组合物,其包含间苯二酚、官能化的杂芳族化合物和视黄酸前体,涉及有效的方法以改善包含此类皮肤有益剂的组合物的颜色稳定性。已发现,与抗氧化剂、相容性油和乳化聚合物组合的烷基间苯二酚、官能化的杂芳族化合物和视黄酸前体提供所述组合物的改善的颜色稳定性。因此,本发明的组合物涉及如下组合物,其包含乳化聚合物与烷基间苯二酚类、官能化的杂芳族化合物和类维生素A、和抗氧化剂和相容性油的组合的的协同组合。
Description
技术领域
在本文中公开了个人护理组合物。更具体地,在本文中公开了化妆品组合物,其包含与抗氧化剂、相容性油、和乳化聚合物组合的烷基间苯二酚、官能化的杂芳族化合物、和视黄酸前体,以提供该组合物的改善的颜色稳定性。
背景技术
理想皮肤的现代定义目前包括年轻的和有弹性的皮肤,在皮肤各处具有均匀颜色分布和平滑质地。然而,人类皮肤通过例如皮肤病学条件、环境侵害(environmentalabuse)(风、空调、日晒、污染、蓝光)或随时间的衰老(chronoaging)而经受恶化。衰老的个体越来越多地出现面部细纹、皱纹、发黄或灰黄、下垂、色素沉着过度、老年斑和一般的衰老迹象。因此,针对可解决此类可见迹象的“抗衰老”或“预衰老(pre-aging)”化妆品的需求已经大幅增长。
近年来,以视黄酸前体例如视黄醇为特征的化妆品组合物已经变得相当突出。也已知为维生素A的视黄醇,和许多它的酯衍生物以及类维生素A(retinoid)家族成员包括例如视黄醇丙酸酯,当被局部施加时可以有效地减少细纹和皱纹,平滑皮肤,并改善不均匀的皮肤色调以及其它益处。尽管类维生素A的益处,但在化妆品组合物中包含视黄酸前体经常导致组合物具有稳定性方面的困难。
此外,许多人经常单独地或甚至同时地寻找提供均匀皮肤色调益处的化妆品。该行业目前的特点是对具有增强的有效性和稳定性的化妆品均匀色调剂的始终存在的需求。此类试剂的实例包括氢醌、熊果苷、曲酸和官能化的杂芳族化合物。不受理论约束或限制,据信含有官能化的杂芳族化合物例如烟酰胺和/或烟酸酯(nicotinate)的组合物可用于促进均匀皮肤和皮肤水合,同时减少皮肤暗沉和细纹的出现,以及其它益处。间苯二酚,特别是烷基间苯二酚类,例如己基间苯二酚和乙基间苯二酚,提供可用于皮肤局部施加中的提供均匀色调益处的试剂的其它实例。
近年来,含有均匀色调剂例如己基间苯二酚的化妆品组合物已经变得非常突出。然而,含烷基间苯二酚的组合物响应于各种因素例如温度、光和氧化而倾向于变色。获得包含间苯二酚的颜色稳定的化妆品组合物是具有挑战性的。当在与烟酰胺和/或类维生素A化合物相同的组成中存在间苯二酚类时,化妆品组合物中的颜色不稳定性问题加剧,当相比于单独地具有各种皮肤有益剂的组合物时,其导致更突出的颜色降解。因此,具有烷基间苯二酚类、官能化的杂芳族化合物和视黄酸前体的化妆品组合物的颜色不稳定性甚至进一步提出有待克服的挑战。
因此,本发明人已经认识到需要开发具有改善的颜色稳定性的化妆品组合物,该化妆品组合物包含烷基间苯二酚、官能化的杂芳族化合物和视黄酸前体。因此,在本文中公开了化妆品组合物,所述化妆品组合物除了乳化聚合物、抗氧化剂和相容性油之外,还具有与(a)官能化的杂芳族化合物、(b)视黄酸前体、或(c)它们的混合物组合的烷基间苯二酚。
附加信息
已经公开了将乳化聚合物加入至具有间苯二酚类、官能化的杂芳族化合物和/或类维生素A的化妆品组合物中的努力。
美国专利申请公开号2003/165546公开含有类维生素A和卡波姆的稳定的个人护理组合物。
第8,440,172号美国专利描述在pH等于或低于7.0的情况下的苯基苯并咪唑磺酸类的可溶性盐。
PCT公开号WO 2019/011618涉及具有颜色稳定化活性物质的纳米乳状液,任选地包含视黄酸前体、间苯二酚和/或聚合物。
PCT公开号WO 2017/194486报道将视黄酸前体稳定化的方法和具有稳定化的视黄酸前体的皮肤益处组合物。
上述的附加信息均未描述乳化聚合物与间苯二酚、官能化的杂芳族化合物、类维生素A、抗氧化剂和相容性油的特定组合,以获得颜色稳定的化妆品组合物,以用于解决在本文中公开的皮肤衰老迹象。
发明内容
本发明人已经发现,除了使用相容性油载体和抗氧化剂之外还使用乳化聚合物,增强了包含视黄酸前体、官能化的杂芳族化合物和烷基间苯二酚的化妆品组合物的颜色稳定性。
因此,在第一方面,本发明的组合物涉及具有乳化聚合物和抗氧化剂的组合物,所述组合物另外包含烷基间苯二酚、官能化的杂芳族化合物、视黄酸前体、或它们的混合物,以及相容性油。
在第二方面,本发明的组合物涉及化妆品组合物,其在化妆品可接受的载剂中包含:(a)一种或多种的烷基间苯二酚化合物;(b)类维生素A、类维生素A酯衍生物、或它们的共混物中的一种或多种;(c)一种或多种的官能化的杂芳族化合物;(d)聚合乳化剂;(e)抗氧化剂;和(f)相容性油。
在第三方面,公开向皮肤提供抗衰老和/或均匀色调益处的方法,其包括以下步骤:(a)制备根据第二方面的包含烷基间苯二酚、官能化的杂芳族化合物和视黄酸前体的颜色稳定的化妆品组合物,和(b)将所述化妆品组合物施加至需要处理的皮肤。
在考虑到下面的详细描述和实施例时,本发明的化妆品组合物的所有其它方面将变得更明显。
为避免疑义,术语“包含”不意味着限制任何陈述的元素,而是涵盖具有主要或次要功能重要性的未指定元素。因此,所列出的步骤、元素或选项不必是穷尽的。无论何时使用“包括”或“具有”时,这些术语都意味着等效于如上定义的“包含”。
在本文中使用的术语“皮肤”包括在面部、颈部、胸部、背部、手臂、腋窝、臀部、手部、腿部和头皮上的皮肤。在本文中使用的皮肤有益剂意味着包括在局部施加后改善面部或身体特征的组分,例如皮肤特征,和/或对所述特征有益的组分,其中该皮肤有益剂可以是并且优选地是在乳霜(cream)、泵或气溶胶喷雾、浆液(serum)、乳液(lotion)、膏剂(balm)、除臭剂、凝胶或洗涤组合物中的皮肤有益剂。在一个特别优选的实施方案中,所述组合物是免洗型(leave-on)组合物,并且皮肤有益剂是类维生素A化合物和油溶性烷基间苯二酚类。如在本文中使用的“单体”是指在化学反应中经历聚合以产生大分子的离散的、非聚合的化学基团(moiety),而“单元”是指已经经历这种聚合反应并且是聚合物的一部分的单体。“聚合物”是指由至少两个单体单元的聚合形成的反应产物。在本文中,“乳化聚合物”与“聚合物乳化剂”互换地使用,并且是指具有乳化、稳定化和/或增加组合物粘度的潜力的多官能的聚合物成分。在本文中使用的术语“类维生素A(retinoid)”和“视黄酸前体”是指具有与在人皮肤中的维生素A相似的生物活性的维生素A的所有天然类似物和/或合成类似物或它们的衍生物。在本文中使用的与成分相关的术语“衍生物”是指在化合物上的官能团取代。在本文中使用的术语“官能化的”是指化合物具有至少一种官能团取代基,包括在化合物上的酰基、羟基、烷氧基、甲酰胺(酰胺)、羧基或烷氧羰基(酯)取代基。如在本文中使用的“基本上不含”旨在意味着包含少于5重量%,优选地少于2重量%,更优选地少于0.5重量%的组合物。在本文中使用的“保持颜色稳定”描述这样的化妆品组合物,基于在4周时在45℃下在Hunter Lab分光光度计上测量的L*、a*和b*色差,所述化妆品组合物具有六(6)或更小的ΔE。一般来说,在45℃下在4周时ΔE≤6是期望的,而ΔE≥6是不期望的。在本文中使用的术语“相容性”是指具有在16.5至22范围内的汉森总溶解度参数值的油。汉森总溶解度参数基于三个汉森参数而确定,即(限定来自分子间分散力的能量)、/>(限定来自分子间偶极分子间力的能量)、和/>(限定来自分子间氢键的能量)。/>值是根据AllanF.M.Barton的CRC Handbook of Solubility Parameters and other CohesionParameters第二版而获得的。在本文中使用的“环境温度”是指20至25℃的温度
除了在实施例中,或在另外明确指出的情况下,在本说明书中表示材料的量的所有数值都应理解为由“约”修饰。除非另有说明,否则所有量均按组合物的总重量计。
具体实施方式
间苯二酚是一种二羟基苯酚化合物(即1,3-二羟基苯),其特征在于在1位和3位处的醇基(-OH)。间苯二酚类的化学结构可以被改变,产生取代的间苯二酚类,其特征在于在2、4、5或6位处的至少一个取代基。优选的是,该间苯二酚类包含至少一个取代基,所述取代基包含5至11个碳原子,优选地5至9个碳原子。特别优选的是,至少一个取代基包括烷基,更优选地包括不饱和的烷基。
优选地,化妆品组合物的所述间苯二酚类仅在4位被烷基取代,即该间苯二酚类是烷基间苯二酚,更优选地是4-取代的烷基间苯二酚。4-取代的烷基间苯二酚类的示例性的但非限制性的实例包括4-乙基间苯二酚、4-己基间苯二酚、4-苯基乙基间苯二酚、4-环戊基间苯二酚、4-环己基间苯二酚、4-辛基间苯二酚、和它们的混合物。该组合物包含按化妆品组合物的重量计0.001%至10%,优选地0.01%至5%,最优选地0.01%至1%的烷基间苯二酚,包括其中包含的所有范围。特别优选的是,该烷基间苯二酚是4-己基间苯二酚、4-乙基间苯二酚、或它们的混合物。
本发明的组合物包含视黄酸前体,其通常包括视黄醇酯、视黄醇、视黄醛、或它们的混合物,优选地包括视黄醛、视黄醇酯或它们的混合物。期望使用的视黄醇酯的实例包括但不限于:视黄醇棕榈酸酯、视黄醇甲酸酯、视黄醇乙酸酯、视黄醇丙酸酯、视黄醇丁酸酯、视黄醇戊酸酯、视黄醇异戊酸酯、视黄醇己酸酯、视黄醇庚酸酯、视黄醇辛酸酯、视黄醇壬酸酯、视黄醇癸酸酯、视黄醇十一烷酸酯、视黄醇牛磺酸酯、视黄醇十三烷酸酯、视黄醇肉豆蔻酸酯、视黄醇十五烷酸酯、视黄醇十七烷酸酯、视黄醇硬脂酸酯、视黄醇异硬脂酸酯、视黄醇十九烷酸酯、视黄醇花生四烯酸酯、视黄醇山萮酸酯、视黄醇亚油酸酯、和视黄醇油酸酯。优选地,所述酯选自视黄醇棕榈酸酯、视黄醇乙酸酯、视黄醇丙酸酯、和它们的混合物。视黄醇亚油酸酯和视黄醇油酸酯也是优选的。在一个特别优选的实施方案中,视黄酸前体是视黄醇丙酸酯、视黄醇、或它们的混合物。按化妆品组合物的重量计,视黄酸前体以0.001%至5%的量,优选地以0.01%至1%的量,最优选地以0.01%至0.5%的量使用,包括其中包含的所有范围。
通常还期望的是,在具有间苯二酚和/或视黄酸前体的化妆品组合物中包含官能化的杂芳族化合物,以提供皮肤益处。除了烷基间苯二酚和视黄酸前体之外,在本文中公开的化妆品组合物还包含官能化的杂芳族化合物。官能化的杂芳族化合物优选地为羧酸官能化的杂芳族化合物。羧酸官能化的杂芳族化合物可以是任何化妆品可接受的烟酸、吡啶甲酸、或它们的衍生物、或它们的混合物,优选地是烟酸、烟酰胺、烟酸酯、吡啶甲酸、吡啶酰胺、或它们的混合物,更优选地是烟酰胺、吡啶酰胺、或它们的混合物。按化妆品组合物的重量计,官能化的杂芳族化合物通常是以0.01%至10%,优选地0.05%至7%,更优选地0.1%至5%的量存在,包括其中包含的所有范围。
现在已经出人意料地确定,在具有烷基间苯二酚、视黄酸前体和官能化的杂芳族化合物的组合物中使用相容性油可以有助于改善的颜色稳定性。具有16.5至22,优选地16.75至20,更优选地17至19.5的汉森总溶解度参数值的油是最相容的,因此理想地用于此类化妆品组合物中。可以用于在本文中公开的组合物中的油的示例性实例包括肉豆蔻酸异丙酯/>辛酸/癸酸甘油三酯/>和棕榈酸异丙酯/>按化妆品组合物的重量计,相容性油以8重量%至40重量%的量,优选地以10重量%至30重量%的量,最优选地以12重量%至25重量%的量来使用,包括其中包含的所有范围。在一个特别优选的方面,所述化妆品组合物包含15重量%至20重量%的相容性油。
在化妆品组合物的范围内的是,另外包含一种或多种抗氧化剂,该抗氧化剂可以是天然的、天然衍生的、或合成的抗氧化剂,因为还出人意料地已经发现它增强在此类化妆品组合物中的颜色稳定性。抗氧化剂可以是需要用于化妆品组合物中的任何抗氧化剂。此类抗氧化剂的示例性但非限制性实例包括α羟基酸类(例如柠檬酸、乳酸、乙醇酸和扁桃酸)、氨基酸类和它们的衍生物、β-羟基酸类(例如丙酸和水杨酸)、丁基化的羟基甲苯(BHT)、胡萝卜素类、类胡萝卜素、辅酶Q10、双十二烷醇3,3’硫代二丙酸酯、谷胱甘肽、咪唑和它们的衍生物、十八烷醇二-叔-丁基-4-羟基氢化肉桂酸酯、季戊四醇四(二-叔-丁基羟基氢化肉桂酸)酯、肽和它们的衍生物、植物提取物(例如迷迭香(Rosmarinusofficinalis)(rosemary)叶提取物和茶(Camellia sinesis)(绿茶)叶提取物)、多羟基酸类(例如葡糖酸、葡糖酸内酯和乳糖酸)、多酚类(例如花色素苷(anthocyanin)、鞣花酸、类黄酮、单宁)、和白藜芦醇。
可用于本发明的化妆品组合物中用作抗氧化剂的另一类包括维生素。示例性维生素包括但不限于维生素B2、维生素B5(泛醇)、维生素B6、维生素C、维生素E、维生素F、维生素K、叶酸和生物素。也可采用维生素的衍生物。例如,维生素C衍生物包括抗坏血酸四异棕榈酸酯、抗坏血酸磷酸酯镁和抗坏血酸糖苷。维生素E的衍生物包括生育酚乙酸酯、生育酚棕榈酸酯和生育酚亚油酸酯。优选的是,抗氧化剂包含BHT、双十二烷醇3,3’硫代二丙酸酯、十八烷醇二-叔-丁基-4-羟基氢化肉桂酸酯、季戊四醇四(二-叔-丁基羟基氢化肉桂酸)酯、多酚类、或它们的混合物。按化妆品组合物的重量计,在本文中公开的化妆品组合物中存在的抗氧化剂的总重量百分比优选地为0.01%至4%,更优选地为0.02%至3%,最优选地为0.05至2%,包括其中包含的所有范围。基于所述组合物的总重量,在化妆品组合物中存在的抗氧化剂的最小总重量百分比是0.15重量%,优选地是0.20重量%。
还已经发现,相比于缺乏此类乳化聚合物的可比组合物,当类维生素A、烷基间苯二酚和官能化的杂芳族化合物与如上所述的相容性油和抗氧化剂以及乳化聚合物组合添加时,出人意料地观测到还进一步增加的颜色稳定性。乳化聚合物包含至少一个选自丙烯酸或丙烯酸酯甲基丙烯酸烷基酰氨丙基的重复阴离子结构单元。期望的乳化聚合物是由纯丙烯酸单体、或丙烯酸单体和甲基丙烯酸单体的混合物制成的可溶胀的聚合物粉末,优选地是具有以下化学名称的聚合物:丙烯酸(酯)类/C10-30烷基丙烯酸酯交联聚合物(Aerylates/C10-30 Alkyl Acrylate Crosspolymer)、卡波姆、或它们的混合物。在一个方面,所述聚合物是交联的或非交联的均聚物。在另一方面,该聚合物是交联的或非交联的共聚物。乳化聚合物是多官能团的,并能够乳化、稳定化和/或增加组合物的粘度。单独采用聚合物乳化剂或采用聚合物乳化剂与其它额外的聚合物乳化剂的组合是在本发明的组合物的范围内。用于本发明的化妆品组合物中的示例性但非限制性丙烯酸(酯)类/C10-30烷基丙烯酸酯交联聚合物从供应商The Lubrizol Corporation以例如PEMULENTM TR-1、PEMULENTMTR-2、PEMULENTM EZ-4U、Ultrez 20、/>Ultrez 21、1382和/>ETD 2020的商品名商业可获得。用于本组合物中的理想的卡波姆包括/>Ultrez 10和/>980,二者均由TheLubrizol Corporation商业销售。按所述组合物的总重量计,乳化聚合物以0.01%至5%的量,优选地以0.02%至4%的量,更优选地以0.03%至3%的量被包含在所述化妆品组合物中。还更优选的是,按所述化妆品组合物的重量计,所述聚合物以0.04重量%至2重量%,最优选地以0.05重量%至1重量%的量被包含在所述化妆品组合物中,包括其中包含的所有范围。
本领域普通技术人员将擅长于识别在本文中公开的乳化聚合物的任何中和需求,以实现需要的和/或最大粘度。可以采用本领域已知的可接受用于个人护理产品和/或医药产品中的任何pH调节剂,以产生具有皮肤可接受的pH值的化妆品组合物,通常所述pH值在4至8的范围内。在一个优选的实施方案中,该化妆品组合物的pH为4.25至7.5,最优选地为5至7。传统的缓冲液或pH调节剂包括常见的添加剂,例如氢氧化钠、氢氧化钾、盐酸、柠檬酸、三乙醇胺和氨甲基丙醇。在本文中公开的化妆品组合物的粘度优选地为1,000至120,000厘泊(cps),更优选地为5,000至80,000cps,所述粘度在环境温度和1s-1的剪切速率的条件下用应变控制平行板流变仪测得,该流变仪从供应商例如T.A.Instruments以Discovery名称商业可获得。可替代地,粘度也可以使用布鲁克菲尔德粘度计(20rpm的速度,转子5,升降架关闭,在环境温度下持续一(1)分钟)来测量。该化妆品组合物可以配制成具有1,000至4,000毫帕斯卡-秒(mPas)的粘度的浆液、具有4,000至10,000mPas的粘度的乳液、具有10,000至20,000mPas的粘度的流体乳霜或具有20,000至100,000mPas或以上的粘度的乳霜。
在本文中公开的化妆品组合物基本上不含额外的表面活性剂,也就是说,按所述组合物的重量计,化妆品组合物包含小于5%,优选地小于2%,更优选地小于0.5%的表面活性剂,部分由于所述乳化聚合物的乳化性质。
然而,本领域普通技术人员将认识到是否存在组合物特定的需要,以包含额外的表面活性剂,所述额外的表面活性剂涵盖相关领域中已知的作为乳化剂的材料的类别。同样,选择使用的任选存在的表面活性剂按化妆品组合物的重量计不会超过5%,优选地不超过2%,更优选地不超过0.5%的表面活性剂的最大包含水平。技术人员还将有见识地基于常见(common)因素选择需要的合适的表面活性剂或表面活性剂组合,所述常见因素包括但不限于表面活性剂的亲水-亲脂平衡(HLB)值、化妆品组合物的pH和化妆品组合物的电解质含量。
乳化剂可选自阴离子表面活性剂、非离子表面活性剂、阳离子表面活性剂和两性表面活性剂。特别优选的非离子表面活性剂是具有以下的那些:与每摩尔疏水物2至100摩尔环氧乙烷或环氧丙烷缩合的C10-C20脂肪醇或脂肪酸疏水物;与2至20摩尔环氧烷缩合的C2-C10烷基酚类;乙二醇的单脂肪酸酯和二脂肪酸酯;脂肪酸单甘油酯;脱水山梨糖醇单-和二-C8-C20脂肪酸;和聚氧乙烯脱水山梨糖醇;以及它们的组合。烷基多糖苷类和糖类脂肪酰胺(例如甲基葡糖酰胺类)也是合适的非离子乳化剂。其它还优选的非离子表面活性剂包括硬脂酸甘油酯、乙二醇硬脂酸酯和硬脂酰胺AMP。
优选的阴离子乳化剂包括烷基醚硫酸盐类和烷基醚磺酸盐类、烷基硫酸酯盐类和烷基磺酸酯盐类、烷基苯磺酸盐类、烷基和二烷基磺基琥珀酸酯盐类、C8-C20酰基羟乙基磺酸酯盐类、C8-C20酰基甲基羟乙基磺酸酯盐类、C8-C20酰基甲基牛磺酸盐类、C8-C20烷基醚磷酸盐类、烷基醚羧酸盐类、和它们的组合。
可使用的阳离子乳化剂包括例如棕榈酰氨丙基三甲基氯化铵、二硬脂基二甲基氯化铵、二酯季铵化合物类(例如二硬脂酰乙基二甲基氯化铵)、和它们的混合物。
通过LabScan XE设备(Hunter Associates Laboratory,Inc.Reston,Virginia)的使用,来确定颜色稳定性。LabScan XE测量颜色数据。在小瓶中或在测量元件中容纳的处于不同储存阶段的样品被装载至LabScan XE测量端口上。通过遵循在相关仪器菜单和计算机软件中指定的测量程序,测量和计算颜色(a*、b*和L*),以得出颜色变化数据(ΔE)值。作为参考,大约三的ΔE是可明显地检测到自原始样品的颜色变化的阈值。
还出人意料地已经发现,用本发明的化妆品组合物制成的其它组合物为该组合物本身提供良好的稳定性和颜色稳定性,以及当被施加至皮肤时抗衰老和均匀色调的益处。
在本文中公开的化妆品组合物还可包含化妆品上可接受的载剂(vehicle)以用作在该组合物中的皮肤有益剂的稀释剂、分散剂或载体(carrier),以便当该组合物被施加至皮肤时促进该组合物的分布。这种化妆品上可接受的载剂可以是水性的、无水的或乳状液(emulsion)。在水和乳化剂的存在下,油性载体会形成作为载体的乳状液系统。优选地,所述组合物是水性的或乳状液,特别是油包水或水包油乳状液,优选地是水包油乳状液。所述化妆品组合物通常会是但不限于以乳霜或乳液的形式。
所采用的合适载体包括水、海水、玫瑰水(例如,突厥蔷薇(Rosa Damascena)花水)、茶(例如,茶(Camellia Sinensis)叶水)、库拉索芦荟(Aloe Barbadensis)(芦荟)叶汁、金缕梅(例如,北美金缕梅(Hamamelis Virginiana)提取物)、薰衣草水(例如,狭叶薰衣草(Lavendula Angustifolia)花水)、葡萄水(例如,葡萄(Vitis Vinifera)果水和葡萄汁)。在一个最优选的实施方案中,水是载体。基于化妆品组合物的重量,水的量可以是5重量%至85重量%,更优选地是15重量%至75重量%,最优选地是30重量%至70重量%,并且包括其中包含的所有范围。在没有其它化妆品辅料的情况下,化妆品上可接受的载剂可以形成该组合物的平衡。除了水之外,期望的载体类别包括但不限于硅酮、多元醇、脂肪酸、烃、甘油三酯、蜡类和增稠剂。
硅酮可分为挥发性和非挥发性种类。量可以是例如按所述组合物的重量计0.01%至8%,更优选地是0.1%至6%。在本文中使用的术语“挥发性”是指那些在环境温度下具有可测量的蒸气压的材料。挥发性硅油优选地选自含有3至9个,优选地含有4至5个硅原子的环状(环聚二甲基硅氧烷(cyclomethicone))或线性聚二甲基硅氧烷类(polydimethylsiloxanes)。
在该组合物中可用的非挥发性硅酮包括聚烷基硅氧烷、聚烷基芳基硅氧烷和聚醚硅氧烷共聚物。在本文中可用的基本上非挥发性的聚烷基硅氧烷包括例如在25℃下具有5×10-6至0.1m2/s的粘度的聚二甲基硅氧烷类。乳化和非乳化硅酮弹性体也适合用于在本文中公开的化妆品组合物中。
在本文中公开的化妆品组合物中可以任选地包含通常为多元醇型材料的常规保湿剂。典型的多元醇包括甘油(即丙三醇)、丙二醇(propylene glycol)、丙二醇(propanediol)、双丙甘醇、聚丙二醇、聚乙二醇、山梨糖醇、羟丙基山梨糖醇、己二醇、1,3-丁二醇、异戊二醇、1,2,6-己三醇、乙氧基化的甘油、丙氧基化的甘油、和它们的混合物。一个最优选的实施方案包括甘油、丙二醇、或它们的混合物。使用的保湿剂的量可以是按化妆品组合物的重量计0.1%至25%,优选地是0.5%至20%,更优选地是1%至15%。
脂肪酸也可以是可用的载体。术语“脂肪”是指在10到30个碳原子之间的碳链长度。该类别的示例是壬酸、月桂酸、肉豆蔻酸、棕榈酸、硬脂酸、异硬脂酸、羟基硬脂酸、油酸、亚油酸、蓖麻油酸、花生酸、山萮酸、芥酸和它们的组合。当使用时,在该组合物中存在0.01至5重量%的脂肪酸。
蜡类和蜡酯类也是适合用于化妆品组合物中。这些蜡类包括动物衍生的蜡类或来自动物副产品的那些(例如,蜂蜡、鲸蜡、中国蜡、羊毛蜡、紫虫胶蜡)、植物衍生的蜡类(例如,三山萮精蜡、巴西棕榈蜡、小烛树蜡、杨梅蜡、霍霍巴蜡、橙蜡、米糠蜡、向日葵蜡、蓖麻蜡、大豆蜡)、矿物蜡类(例如,褐煤蜡、微晶蜡、地蜡)、和天然蜡的合成衍生物。使用的蜡和蜡酯的量可以是按所述组合物的重量计0.01%至10%,优选地是0.1%至8%。
除了可用作相容性油的具有在本发明的化妆品组合物的范围内的汉森总溶解度参数值的甘油三酯油类之外,甘油三酯类是另一组可用作载体的材料。示例性但非限制性的实例是葵花籽油、棉籽油、芥花籽油、葡萄籽油、大豆油、蓖麻油、琉璃苣油、橄榄油、牛油树脂、霍霍巴油、和它们的混合物。单甘油酯类和甘油二酯类也可以是可用的。这些类别的示例是甘油单硬脂酸酯和甘油二硬脂酸酯。甘油三酯类的量可以是按所述组合物的重量计0.01%至10%,优选地是0.1%至8%。
除了先前在本文中描述的乳化聚合物之外,所述化妆品组合物还可以任选地包含一种或多种增稠剂,优选地所述增稠剂的量为按所述组合物的重量计0.05%至3%,更优选地是0.1%至2%,甚至更优选地是0.2%至1%。可用的增稠剂包括多糖类,所述多糖类包括淀粉类、天然/合成树胶类和纤维素类。期望的淀粉类包括木薯淀粉、玉米淀粉、马铃薯淀粉、淀粉辛烯基琥珀酸铝和羟丙基淀粉磷酸钠。期望的树胶包括黄原胶、菌核胶、果胶、刺梧桐胶、阿拉伯胶、琼脂、瓜耳胶、角叉菜胶、藻酸盐胶、和它们的组合。期望的纤维素类包括羟丙基纤维素、羟丙基甲基纤维素、乙基纤维素和羧基甲基纤维素钠。用作增稠剂的合成聚合物也是期望使用的,包括牛磺酸酯共聚物。
在本文中公开的化妆品组合物中可以任选地包括香精、皮肤有益剂、固定剂和研磨剂。皮肤有益剂包括但不限于遮光剂、着色剂、保湿剂、润肤剂、包藏剂、植物提取物、光学剂、均匀色调剂、抗炎剂、抗痤疮剂、防晒剂、抗氧化剂、光稳定剂、表面活性剂、皱纹减少剂、脱屑促进剂、去角质剂、它们的混合物等。按所述化妆品组合物的重量计,这些物质中的每一种可以以0.05重量%至5重量%,优选地以0.1重量%至3重量%的量存在。
在所述化妆品组合物中可以任选地包含烃。期望的烃可包括矿物油、矿脂和聚α-烯烃。优选的挥发性烃的实例包括:多癸烷类(polydecanes),例如异癸烷和异十二烷;C7-C8至C12-C15异链烷烃类。
类维生素A助促进剂也可以是可用的成分,以加入用于在本文中公开的组合物中,例如脂肪酸类和它们的衍生物。例如Granger等人的几项美国专利(美国专利号5,759,556、5,759,556、5,756,109、5,747,051、5,716,627、5,811,110、5,536,740、5,747,051、5,599,548、5,955092、5,885,595、5,759,556、5,693,330、7,959,913、8,226,933和8,409,550)中所述,术语“类维生素A助促进剂”用于统称已经被确定能增强视黄醇酯和视黄醇向视黄酸的酶促转化的化合物,该酶促转化作为在皮肤表皮中的天然视黄醇代谢过程的一部分。单独的助促进剂或与其它助促进剂化合物组合的助促进剂有助于增强视黄酸前体的功效。术语“脂肪”是指10到30个碳原子之间的碳链长度。该类别的示例是壬酸、月桂酸、肉豆蔻酸、棕榈酸、硬脂酸、异硬脂酸、羟基硬脂酸、油酸、亚油酸、蓖麻油酸、花生酸、山萮酸、芥酸和它们的组合。此类脂肪酸的优选的衍生物包括脂肪醇,例如鲸蜡醇、月桂醇、肉豆蔻醇、棕榈醇、鲸蜡硬脂醇、硬脂醇和油醇;脂肪酯,例如2-乙基-己基肉豆蔻酸酯、硬脂酸异丙酯和异硬脂醇棕榈酸酯、三亚油酸三异丙酯和三月桂醇柠檬酸酯、月桂醇棕榈酸酯、肉豆蔻醇乳酸酯、油醇芥酸酯(oleyl eurcate)和硬脂醇油酸酯、椰油醇-辛酸酯/癸酸酯(椰油醇-辛酸酯和椰油醇-癸酸酯的共混物)、丙二醇肉豆蔻醇醚乙酸酯、己二酸二异丙酯和鲸蜡醇辛酸酯;和脂肪酰胺类,例如椰油酰胺单乙醇酰胺(CMEA)、蓖麻油单乙醇酰胺、亚油酰单乙醇酰胺(linoleoyl monoethanolamide)(LAMEA)、棕榈酰胺单乙醇酰胺和亚油酰胺二乙醇酰胺。
此类助促进剂化合物的其它示例性但非限制性实例包括类胡萝卜素、类黄酮、环状和非环状香精、抗真菌剂(antimicotics)(例如,联苯苄唑、氯咪巴唑、克霉唑、益康唑、酮康唑、咪康唑)、磷脂类似物、脲、磷脂酰乙醇胺(phosphatiylethanolamine)、磷脂酰胆碱、鞘磷脂、天然着色剂(例如,香豆素)、喹啉类、异喹啉类、美替拉酮、和它们的混合物。在一个实施方案中,脂肪酸、脂肪醇、脂肪酰胺、氯咪巴唑、或它们的混合物可用作类维生素A助促进剂。在一个特别优选的实施方案中,12-羟基硬脂酸、鲸蜡醇、鲸蜡硬脂醇、CMEA、LAMEA、氯咪巴唑、或它们的混合物用作类维生素A助促进剂。当使用时,在所述组合物中存在0.01重量%至5重量%的类维生素A助促进剂化合物。
可选地包含防晒剂和光稳定剂在化妆品组合物的范围内。可用于化妆品组合物中的防晒剂和光稳定剂包括材料例如辛基甲氧基肉桂酸酯(OMK)、水杨酸乙基己酯、苯基苯并咪唑磺酸(恩索利唑(Ensulizole))、对甲氧基肉桂酸乙基己酯,作为PARSOL 可获得、阿伏苯宗(Avobenzene)(丁基甲氧基二苯甲酰基甲烷),作为PARSOL />可获得、和二苯酮-3,也已知为氧苯酮。可使用无机防晒剂活性物质,例如微细二氧化钛(优选地,具有小于150纳米(nm),最优选地小于100nm的粒径)和氧化锌,聚乙烯和各种其它聚合物也是期望的防晒剂。期望使用的其它防晒剂包括对氨基苯甲酸(PABA)、辛基二甲基-PABA、对甲氧基肉桂酸2-乙氧基乙酯、二苯酮-1、二苯酮-2、二苯酮-6、二苯酮-8、二苯酮-9、二苯酮-12、高甲基水杨酸酯(homomethyl salicylate)、薄荷醇邻氨基苯甲酸酯、二苯酮-4、三乙醇胺水杨酸酯、对苯二亚甲基二樟脑磺酸(terephthalylidene dicamphor sulfonic acid)、二奥克三唑(bisoctriazole)、二乙基己氧基苯酚甲氧基苯基三嗪、苯基二苯并咪唑四磺酸二钠(bisdisulizoledisodium)、甲酚曲唑三硅氧烷(diometriazole trisiloxane)、辛基三嗪酮、二乙基己基丁酰胺基三嗪酮(iscotrizinol)、聚硅氧烷-15、异戊烯基-4-甲氧基肉桂酸酯、它们的混合物等。同样期望使用的是奥克立林(octocrylene)。按化妆品组合物的重量计,防晒剂或光稳定剂的量当存在时通常可以是以0.1%至20%,优选地以0.5%至15%,最佳地以0.75%至10%的量存在。
期望使用的其它额外的任选存在的皮肤有益剂包括矿物质和皮肤营养物,例如:牛奶;镁、钙、铜、锌和其它金属组分;曲酸;氢醌和熊果苷;糖类同分异构体;十一碳烯酰苯丙氨酸;鞘脂类、磷脂类(例如植物鞘氨醇)、神经酰胺类(例如神经酰胺1、神经酰胺3、神经酰胺3B和神经酰胺6)和假神经酰胺类;尿囊素;焦谷氨酸(PCA)盐衍生物,包括PCA锌和PCA钠;岩芹酸;共轭的亚油酸;十八烷酸;透明质酸和它的盐衍生物;和它们的混合物等。当使用时,此类皮肤有益剂总共占化妆品组合物的重量的0.001%至12%。
在化妆品组合物中可任选地包含多种植物性提取物。该提取物可以或者是可溶解于水或者是可溶解于油中,分别被携载在亲水性或疏水性的溶剂中。在一个优选的实施方案中,水或乙醇是提取溶剂。示例性实例包括:那些从绿茶、西洋蓍草、洋甘菊、甘草、芦荟、温州蜜柑(citrus unshui)、柳树皮、苜蓿、藻类(algae)、金缕梅、鼠尾草、麝香草和迷迭香中提取的那些;以及油类,例如从沙棘、辣木、阿干树(argan)、鳄梨、金盏花、海藻(algal)和马鲁拉树(marula)中提取的那些。可使用大豆提取物,特别是当需要包含视黄醇时。当使用时,此类提取物优选地以按化妆品组合物的重量计0.001重量%至12重量%的总量使用。
任选地,在本文中公开的化妆品组合物中也可以包含一种或多种着色剂。着色剂包括天然或合成来源的染料或颜料。选择使用的染料可以是有机的或无机的,并且是水溶性的或油溶性的。水溶性染料的示例性和非限制性实例包括例如D&C Yellow 8、D&CYellow 10、D&C Orange 4、D&C Red 6、D&C Red 22、D&C Red 28、D&C Red 33、D&C Green 5或亚甲基蓝。油溶性染料包括例如D&C Red 17、D&C Green 6、β-胡萝卜素、D&C Violet 2、D&C Yellow 11、D&C Orange 5和喹啉黄。期望使用的颜料特别地选自如在本领域中已知的矿物颜料、有机颜料、色淀、和它们的混合物。示例性但非限制性的实例包括:矿物颜料,例如二氧化钛、赭石类(黄赭石、红赭石、棕赭石、氢氧化铁)、金属氧化物(氧化锌、氧化锆、氧化铁、氧化铈、氧化铬)、锰紫、群青蓝、水合铬和铁蓝,或金属粉末(铝、青铜或铜粉);有机颜料,例如亚硝基、硝基、偶氮、酞菁、二嗪、呫吨、芘、喹啉、蒽醌、三苯基甲烷、荧烷、喹吖啶酮、金属络合物、异吲哚啉酮、异吲哚啉、紫环酮、二萘嵌苯、二酮基吡咯并吡咯、靛蓝、硫靛、二噁嗪、三苯基甲烷和喹啉酮(quinophthalone)化合物;和色淀(特别是衍生自钙盐、钡盐、铝盐和锶盐的那些),例如D&C Red No.6Barium Lake、D&C Red No.7Calcium Lake、D&C RedNo.27Aluminum Lake、D&C Red No.28Aluminum Lake、D&C Red No.33Aluminum Lake、FD&CRed No.40Aluminum Lake、FD&C Yellow No.5Aluminum Lake、FD&C Yellow No.6AluminumLake、D&C Yellow No.10Aluminum Lake、D&C Orange No.5Aluminum Lake和F&D BlueNo.1Aluminum Lake。还期望在本文中公开的化妆品组合物中包含珍珠母类,例如涂有金属氧化物、氯氧化铋或天然颜料的天然云母。期望使用的其它着色剂包括白垩、活性炭和碳黑。当着色剂被使用时,相对于化妆品组合物的重量,化妆品组合物包含0.01重量%至20重量%,优选地0.1重量%至15重量%,更优选地0.5重量%至10重量%的着色剂。
根据需要可以将防腐剂加入至本发明的化妆品组合物中,以防止潜在有害微生物的生长。化妆品化学家熟悉合适的防腐剂,并常规地选择它们以满足防腐剂测试和产品稳定性测试。防腐剂体系的选择应考虑组合物的用途以及防腐剂与配制物中的其它成分之间可能的不相容性。用于本文中公开的化妆品组合物的防腐剂的典型实例包括但不限于:碘丙炔醇丁基氨甲酸酯(IPBC)、苯氧乙醇、乙基己基甘油、1,2-辛二醇、羟苯甲酯、羟苯丙酯、咪唑烷基脲、脱氢乙酸钠、丙二醇、对羟基苯甲酸的烷基酯、羟基苯乙酮、DMDM乙内酰脲衍生物、氯咪巴唑、丙酸盐和各种季铵化合物。防腐剂优选地以按所述组合物的重量计0.01%至2%的量使用。
当制备本发明的化妆品组合物时,通过常规方法混合需要的成分。如果适用,油相和水相使用标准混合器和混合叶片来分别地混合,并在大气压下被加热至通常22至85℃的温度。在达到需要的温度后,向所述水相添加所述油相以形成乳状液。随后,不按特定顺序添加并混合化妆品组合物中的其它成分。
在本文中公开的化妆品组合物是适合用于局部施加至人类皮肤的组合物,包括免洗型(leave-on)和洗去型(wash-off)产品。优选地,所述术语涵盖流体液体,特别是润肤霜(moisturizer),而不是化妆产品(make-up product)。最优选的是免洗型组合物。在本文中使用的与组合物相关的术语“免洗型”是指施加至皮肤或擦在皮肤上并留在皮肤上的组合物。
许多类型的包装可以用于储存和递送本发明的化妆品组合物。包装的选择取决于个人护理最终用途和组合物本身的粘度。作为实例,用于皮肤的免洗型乳液和乳霜通常使用塑料容器,其中在分配端处的开口由合适的封闭物覆盖。常规的封闭物包括带翻盖的铰链盖、螺旋盖和非气溶胶泵。作为另一个实例,如果所述组合物是流体且具有较低粘度,则待用于止汗剂、除臭剂和脱毛剂的适当包装包括在分配端具有滚珠涂抹器的容器。如果所述组合物是以棒(stick)形式,则具有伸缩(propel-repel)机构的容器是合适的,其中该棒被固定在平台上朝向分配孔口。如果该组合物是以气溶胶形式,那么由推进剂加压且具有喷嘴的金属罐是合适的。一般来说,贴片、瓶子、管子、滚珠涂抹器、挤压容器或有盖广口瓶是优选的。
在另一方面,本发明的组合物涉及向皮肤提供抗衰老和/或均匀色调益处的方法,其包括以下步骤:(a)制备根据第二方面的包含烷基间苯二酚、官能化的杂芳族化合物和视黄酸前体的颜色稳定的化妆品组合物,和(b)将所述化妆品组合物施加至需要处理的皮肤。
现在,以下在具体的非限制性实施例的上下文中,将描述所述化妆组合物,以有助于对本发明的化妆品组合物的更好的理解。本领域普通技术人员将认识到,在不偏离本发明的组合物的教导的情况下,可实施与所给出的实施例不同的本发明的组合物的变体。
实施例
通过在中等剪切、22℃至85℃和大气压的条件下混合提及的成分,制成了所有样品。所有数据均采集自CRC Handbook of Solubility Parameters and Other CohesionParameters,第二版(Allan F.M Barton)。
实施例1:具有3%的烟酰胺、0.4%的4-己基间苯二酚和0.3%的视黄醇丙酸酯的配制物
成分 | 重量百分比(wt%) |
水 | 余量 |
甘油 | 3.50 |
螯合剂 | 0.10 |
聚合物/增稠剂 | 0.50 |
烟酰胺 | 3.00 |
中和剂 | 0.20 |
防腐剂 | 0.20 |
鲸蜡醇 | 0.50 |
乳化剂类 | 0.50 |
抗氧化剂类 | 0.20 |
油 | 15.0 |
4-己基间苯二酚 | 0.40 |
视黄醇丙酸酯 | 0.30 |
根据本发明的化妆品组合物,通过将上述成分组合,制成了乳状液化妆品组合物。可改变所选择的抗氧化剂、油类和聚合物/增稠剂的包含水平和特定特性(identity),以观测每个因素对所述组合物的颜色稳定性的影响。
实施例2:在组合物中评估的不同类型的表面活性剂
实施例2证明了,在具有抗氧化剂和乳化聚合物的相容性油载体中包含烷基间苯二酚(例如,4-己基间苯二酚)、官能化的杂芳族化合物(例如,烟酰胺)和视黄酸前体(例如,视黄醇丙酸酯)的组合物,在经受45℃的条件4周后,都产生了需要的ΔE值,而不论在此类组合物中的表面活性剂选择。样品1是说明目前公开的化妆品组合物的主要组合物,举例说明优异的2.9的ΔE值。在随后的实施例中,样品1被引用作为阳性对照,其它样品与该阳性对照进行比较和分析。总之,在实施例2中的数据表明了,在化妆品组合物中存在的表面活性剂的特性(identity)对该组合物是否具有改善的颜色稳定性没有很大贡献。
实施例3:在组合物中评估的不同类型的乳化聚合物
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在实施例3中评估的所有样品包含了与0.4wt%的4-己基间苯二酚、3wt%的烟酰胺和0.33wt%的视黄醇丙酸酯组合的0.2wt%的抗氧化剂和15wt%的相容性油。聚合物以足以达到浆液样粘度的量被包含在所有样品中,因此特定聚合物(例如ACULYNTM 33)以更高的浓度使用,以建立需要的粘度并构建高负荷的油性成分。尽管乳化聚合物的类型不同,样品1和样品5至样品11产生了需要的ΔE值,并且出人意料地发现了,此类聚合物具有丙烯酸(酯)类/C10-30烷基丙烯酸酯交联聚合物或卡波姆化学名称。通过改变丙烯酸(酯)类/C10-30烷基丙烯酸酯交联聚合物的包含水平,特别是PEMULENTM EZ-4U的包含水平,配制了样品1、样品1a和样品1b,并且在4周45℃条件下,所有这些样品证实了优异的颜色稳定性(即,表现出小于3的ΔE值)。然而,样品12至样品19包含了本发明的化妆品组合物的范围之外的乳化聚合物,并且没有产生需要的ΔE值,如果能够测量出ΔE值的话,考虑到样品15、样品18和样品19被观察到分离。
实施例4:在组成中评估的不同类型和量的抗氧化剂
进行了实验,以评估改变在化妆品组合物中的抗氧化剂的特性和包含水平的影响,其中结果被显示在实施例4中。在实施例4中给出的所有样品包含了与0.4wt%的4-己基间苯二酚、3wt%的烟酰胺和0.33wt%的视黄醇丙酸酯组合的恒定类型和浓度的相容性油。在缺乏任何抗氧化剂的样品20中,ΔE值测得为10.3,超过可接受的6的ΔE限值。在样品21中,当相比于阳性对照样品1时,各种抗氧化剂(即季戊四醇四(二-叔-丁基羟基氢化肉桂酸)酯和双十二烷醇3,3’硫代二丙酸酯)的包含水平降低了一半,但仍观测到可接受的6的ΔE值。在样品22和样品23中,尽管改变抗氧化剂的组合,但仍产生了需要的组合物颜色稳定性。
实施例5:在组合物中评估的不同类型和量的相容性油
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在实施例5示出的样品评估了改变根据本发明的化妆品组合物适合使用的相容性油载体的类型和包含水平的影响,而将抗氧化剂、乳化聚合物、烷基间苯二酚、官能化的杂芳族化合物和视黄酸前体的类型和包含水平保持不变。
按所述组合物的重量计,样品24的相容性油的总量为10重量%,而在样品25中的相容性油的总量为按所述组合物的重量计20重量%。样本24和样本25二者都产生了在需要范围内的ΔE值。因此,实施例5表明了,总共以按所述组合物的重量计10重量%至20重量%的相容性油的使用产生了需要的ΔE值,因此产生了颜色稳定性。样品26至样品28在15%的一致水平下改变了油的类型,其中只有含有棕榈酸异丙酯的样品26产生了在可接受的范围内的ΔE值,而分别含有聚二甲基硅氧烷和异十六烷的样品27和样品28产生了在可接受的范围之外的ΔE值。对于样品29,相容性油的总量为按所述组合物的重量计5重量%,而在样品30中,相容性油的总量为按所述组合物的重量计7.5重量%。由于样品29和样品30二者都是在所公开的化妆品组合物的范围之外的情况下制备的,因此得到的ΔE值超过了6的所需上限。
Claims (12)
1.化妆品组合物,其包含:
(a)烷基间苯二酚;
(b)视黄酸前体;
(c)官能化的杂芳族化合物;
(d)抗氧化剂;
(e)按所述化妆品组合物的重量计,8%至40%的至少一种相容性油,其中所述油具有16.5至22的汉森总溶解度参数;和
(f)乳化聚合物;其中所述官能化的杂芳族化合物包含羧酸官能化的杂芳族化合物,并且另外其中所述化妆品组合物包含0.001重量%至5重量%的所述官能化的杂芳族化合物;其中所述羧酸官能化的杂芳族化合物包括烟酸、吡啶甲酸、烟酸酯、烟酰胺、吡啶酰胺、或它们的混合物;其中所述乳化聚合物包括丙烯酸(酯)类/C10-30烷基丙烯酸酯交联聚合物、卡波姆、或它们的混合物,并且另外其中所述化妆品组合物包含0.01重量%至5重量%的乳化聚合物。
2.根据权利要求1所述的化妆品组合物,其中所述烷基间苯二酚在4-位具有烷基取代基。
3.根据前述权利要求中的任意一项所述的化妆品组合物,其中所述烷基间苯二酚包括4-己基间苯二酚、4-乙基间苯二酚、4-苯基乙基间苯二酚、4-环戊基间苯二酚、4-环己基间苯二酚、4-辛基间苯二酚、和它们的混合物,并且另外其中所述化妆品组合物包含0.001重量%至10重量%的烷基间苯二酚。
4.根据前述权利要求中的任意一项所述的化妆品组合物,其中所述视黄酸前体包括视黄醇酯类、视黄醇、视黄醛酯、视黄酸、和它们的混合物,并且另外其中所述化妆品组合物包含0.001重量%至5重量%的所述视黄酸前体。
5.根据前述权利要求中的任意一项所述的化妆品组合物,其中所述抗氧化剂包括丁基化的羟基甲苯、双十二烷醇3,3’硫代二丙酸酯、十八烷醇二-叔-丁基-4-羟基氢化肉桂酸酯、季戊四醇四(二-叔-丁基羟基氢化肉桂酸)酯、多酚类、或它们的混合物,并且另外其中,所述化妆品组合物包含0.01重量%至4重量%,优选地0.02重量%至3重量%的抗氧化剂。
6.根据前述权利要求中的任意一项所述的化妆品组合物,其中所述化妆品组合物包含按所述化妆品组合物的重量计至少0.2%的抗氧化剂。
7.根据前述权利要求中的任意一项所述的化妆品组合物,其中,所述化妆品组合物包含具有16.75至20,优选地17至19.5的汉森总溶解度参数的相容性油。
8.根据前述权利要求中的任意一项所述的化妆品组合物,其中,所述化妆品组合物包含10重量%至30重量%,优选地12重量%至25重量%,更优选地15重量%至20重量%的相容性油。
9.根据前述权利要求中的任意一项所述的化妆品组合物,其中所述化妆品组合物包含选自肉豆蔻酸异丙酯、棕榈酸异丙酯、辛酸/癸酸甘油三酯、或它们的混合物的相容性油。
10.根据前述权利要求中的任意一项所述的化妆品组合物,其中所述化妆品组合物基本上不含额外的表面活性剂。
11.根据前述权利要求中的任意一项所述的化妆品组合物,其中所述化妆品组合物另外包含12-羟基硬脂酸、防晒剂、磷脂、神经酰胺、或它们的混合物中的至少一种。
12.根据前述权利要求中的任意一项所述的化妆品组合物,其中所述化妆品组合物在45℃下在4周时具有小于或等于6的ΔE值。
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US5599548A (en) | 1995-05-08 | 1997-02-04 | Elizabeth Arden Co., Division Of Conopco, Inc. | Skin care compositions containing fatty acid amides and retinol or retinyl ester |
US5536740A (en) | 1995-06-01 | 1996-07-16 | Elizabeth Arden Company, Division Of Conopco, Inc. | Skin care compositions containing dimethyl imidazolidinone and retinol or retinyl ester |
US5693330A (en) | 1996-04-25 | 1997-12-02 | Elizabeth Arden Co., Division Of Conopco, Inc. | Skin care compositions containing melinamide and a retinoid |
US5716627A (en) | 1996-04-25 | 1998-02-10 | Elizabeth Arden Co., Division Of Conopco, Inc. | Skin care compositions containing fatty acid amides, azoles, and retinol or retinyl ester |
US5885595A (en) | 1996-05-13 | 1999-03-23 | Elizabeth Arden Co., Division Of Conopco, Inc. | Cosmetic composition with a retinol fatty acid ester |
US5756109A (en) | 1996-09-27 | 1998-05-26 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Skin care compositions containing geranyl geraniol and retinol or retinyl esters |
US5955092A (en) | 1996-09-27 | 1999-09-21 | Elizabeth Arden Co., Division Of Conopco, Inc. | Skin care compositions containing an n-substituted fatty acid amide and retinol or retinyl ester |
US5759556A (en) | 1996-09-27 | 1998-06-02 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Skin care compositions containing certain cyclic aliphatic unsaturated compounds and retinol or retinyl ester |
US5747051A (en) | 1996-09-27 | 1998-05-05 | Elizabeth Arden Co., Division Of Conopco, Inc. | Skin care compositions containing an amide of a hydroxy fatty acid and a retinoid |
CZ20024220A3 (cs) | 2000-06-30 | 2003-06-18 | Unilever N. V. | Prostředek pro péči o pleť |
US20030165546A1 (en) | 2002-03-04 | 2003-09-04 | The Procter & Gamble Company | Stable personal care compositions containing a retinoid |
BRPI0721862B1 (pt) | 2007-07-09 | 2016-03-15 | Symrise Ag | preparação compreendendo sais solúveis estáveis de ácido fenilbenzimidazol sulfônico, e uso de aminoácidos básicos |
CN109152713B (zh) | 2016-05-12 | 2021-11-02 | 联合利华知识产权控股有限公司 | 稳定视黄酸前体的方法和具有稳定视黄酸前体的皮肤有益组合物 |
US20210000707A1 (en) | 2017-07-12 | 2021-01-07 | Conopco, Inc., D/B/A Unilever | Nanoemulsions with color stabilized actives |
US20220323324A1 (en) * | 2019-10-25 | 2022-10-13 | Conopco, Inc., D/B/A Unilever | Cosmetic composition with enhanced color stability |
WO2021228502A1 (en) * | 2020-05-09 | 2021-11-18 | Unilever Ip Holdings B.V. | Personal care composition with visually distinct aqueous and oil phase |
WO2021228503A1 (en) * | 2020-05-09 | 2021-11-18 | Unilever Ip Holdings B.V. | Personal care composition with visually distinct aqueous and oil phase |
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