CN1179745C - Chinese medicine preparation for curing choleithiasis and cholecystitis and production method thereof - Google Patents
Chinese medicine preparation for curing choleithiasis and cholecystitis and production method thereof Download PDFInfo
- Publication number
- CN1179745C CN1179745C CNB031175597A CN03117559A CN1179745C CN 1179745 C CN1179745 C CN 1179745C CN B031175597 A CNB031175597 A CN B031175597A CN 03117559 A CN03117559 A CN 03117559A CN 1179745 C CN1179745 C CN 1179745C
- Authority
- CN
- China
- Prior art keywords
- calculus
- cholecystitis
- chinese medicine
- medicine preparation
- grams
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003814 drug Substances 0.000 title claims abstract description 24
- 238000002360 preparation method Methods 0.000 title claims abstract description 23
- 201000001352 cholecystitis Diseases 0.000 title claims abstract description 19
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 10
- 241000218176 Corydalis Species 0.000 claims abstract description 18
- 244000025254 Cannabis sativa Species 0.000 claims description 25
- 238000000034 method Methods 0.000 claims description 19
- 238000011282 treatment Methods 0.000 claims description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 7
- 238000000605 extraction Methods 0.000 claims description 7
- 239000000843 powder Substances 0.000 claims description 6
- 229940079593 drug Drugs 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 3
- 239000000706 filtrate Substances 0.000 claims description 3
- 239000008187 granular material Substances 0.000 claims description 3
- 238000002347 injection Methods 0.000 claims description 3
- 239000007924 injection Substances 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 239000006187 pill Substances 0.000 claims description 3
- 239000002775 capsule Substances 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 239000002994 raw material Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 abstract description 11
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract description 6
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 abstract description 4
- 210000000941 bile Anatomy 0.000 abstract description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract description 4
- 231100000331 toxic Toxicity 0.000 abstract description 4
- 230000002588 toxic effect Effects 0.000 abstract description 4
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 abstract description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract description 2
- 241000194032 Enterococcus faecalis Species 0.000 abstract description 2
- 241000191967 Staphylococcus aureus Species 0.000 abstract description 2
- 239000003613 bile acid Substances 0.000 abstract description 2
- BPYKTIZUTYGOLE-UHFFFAOYSA-N billirubin-IXalpha Natural products N1C(=O)C(C)=C(C=C)C1=CC1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(C=C3C(=C(C=C)C(=O)N3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-UHFFFAOYSA-N 0.000 abstract description 2
- 229910052791 calcium Inorganic materials 0.000 abstract description 2
- 239000011575 calcium Substances 0.000 abstract description 2
- 238000001727 in vivo Methods 0.000 abstract description 2
- 230000003908 liver function Effects 0.000 abstract description 2
- HVYWMOMLDIMFJA-UHFFFAOYSA-N 3-cholesterol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)CCCC(C)C)C1(C)CC2 HVYWMOMLDIMFJA-UHFFFAOYSA-N 0.000 abstract 1
- 241000193830 Bacillus <bacterium> Species 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 abstract 1
- 241001633683 Centipeda <firmicute> Species 0.000 abstract 1
- 206010008616 Cholecystitis and cholelithiasis Diseases 0.000 abstract 1
- 208000037386 Typhoid Diseases 0.000 abstract 1
- 230000003405 preventing effect Effects 0.000 abstract 1
- 201000008297 typhoid fever Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 description 8
- 239000000284 extract Substances 0.000 description 8
- 201000001883 cholelithiasis Diseases 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 208000015924 Lithiasis Diseases 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 208000000913 Kidney Calculi Diseases 0.000 description 2
- 206010029148 Nephrolithiasis Diseases 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 2
- 229940023488 pill Drugs 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 206010007027 Calculus urinary Diseases 0.000 description 1
- 241001649190 Campsis Species 0.000 description 1
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 description 1
- 244000192528 Chrysanthemum parthenium Species 0.000 description 1
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 206010020524 Hydronephrosis Diseases 0.000 description 1
- 241000218180 Papaveraceae Species 0.000 description 1
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 description 1
- 208000006568 Urinary Bladder Calculi Diseases 0.000 description 1
- 208000009911 Urinary Calculi Diseases 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000002279 cholagogic effect Effects 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 235000008384 feverfew Nutrition 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 229940100691 oral capsule Drugs 0.000 description 1
- 230000008058 pain sensation Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The present invention relates to a traditional Chinese medicine preparation for curing chololith and cholecystitis and a production method thereof. The traditional Chinese medicine preparation is mainly prepared from Herba Lysimachiae and accessorily prepared from small centipeda herb and corydalis according to the conventional technology. The prepared preparation has a chololith preventing action mechanism that the preparation increases the concentration of bile acid in bile, reduces the content of cholesterin, calcium and HCO3, reduces the percentage of bilirubin and unconjugated bilirubin and improves the liver function in vivo. The present invention has can kill colibacillus and typhoid bacillus, can inhibit streptococcus faecalis and staphylococcus aureus, can also obviously increase the bile flow, can reduce acetic acid torsion reaction and can cure cholecystitis and cholelithiasis. The present invention has the advantages of no toxic and side effect, exact curative effect and low cost and is easily accepted by patients.
Description
Technical field: the present invention is a kind of Chinese medicine preparation and production method thereof for the treatment of calculus and cholecystitis, belongs to technical field of medicaments.
Technical background: in the modern life, owing to the influence of some living habit, suffer from calculous patient's quantity in continuous increase, the sickness rate of cholecystitis also constantly rises simultaneously, for the reasonable Therapeutic Method of calculosis is operative treatment, but its expense has wound, pain sensation strong than higher, patient; With Western medicine calculosis and cholecystitis thereof have been treated certain effect, but its expense height, toxic and side effects are big, taboo are arranged for other complication that produces by this class disease; Some enterprises of China also utilize herbal development, produced the medicine of some treatments, but the problem that exists is: the medicine formation is numerous and diverse, preparation method is complicated, and cost height and effect are imprecise.
Summary of the invention: the objective of the invention is to: provide a kind of Chinese medicine preparation and production method thereof for the treatment of calculus and cholecystitis according to minority area, Guizhou Province national prescription handed down from one's ancestors; This medicine is for calculosis, as: disease such as disease such as cholelithiasis, renal calculus and cholecystitis has reasonable therapeutic effect and does not have toxic and side effects, and in addition, its preparation method is easy, and medical material is easily got and is easy to get, low production cost.The present invention constitutes like this: the Chinese medicine preparation of treatment calculus and cholecystitis: be prepared from the calculus grass; If calculate according to composition by weight: then it is prepared from calculus grass 2000-3500, Herba Centipedae 100-200; Wherein the calculus grass has the effect of lithodialysis, calculus, anti-inflammatory analgesic, is used for diseases such as cholelithiasis, red duct ligation stone, cholecystitis, renal calculus, hydronephrosis, vesical calculus; Add Herba Centipedae and play the urinary calculus removing effect of assisting; In order to obtain better effect, this product is calculated according to composition by weight: be prepared from calculus grass 2000-3500, Herba Centipedae 100-200, Rhizoma Corydalis 100-200; Add the Rhizoma Corydalis main purpose and be to play analgesic activity, remove patient's misery; Prescription is more accurately: it forms fully with calculus grass 2700 grams, Herba Centipedae 150 grams, Rhizoma Corydalis 150 restraints.The production method of the Chinese medicine preparation of this treatment calculus and cholecystitis, water are carried or the method for alcohol extraction extracts from the calculus grass that the common process according to pharmacy is prepared into any pharmaceutical formulation with it after the active ingredient; Perhaps calculate according to composition by weight: water is carried or the method for alcohol extraction extracts the active ingredient of calculus grass 2000-3500, Herba Centipedae 100-200, and the common process according to pharmacy is prepared into medicinal oral preparation or injection with it then; Also can calculate according to composition by weight: water is carried or the method for alcohol extraction extracts the active ingredient of calculus grass 2000-3500, Herba Centipedae 100-200, Rhizoma Corydalis 100-200, and the common process according to pharmacy is prepared into capsule preparations, tablet, granule, pill, oral liquid with it then; Method is the most accurately: calculus grass 270 grams, Herba Centipedae 15 grams, Rhizoma Corydalis 15 grams are pulverized, sieved, standby, remaining calculus grass, Herba Centipedae, Rhizoma Corydalis are decocted with water three times, each 3 hours again, gradation filters, merging filtrate, being concentrated into relative density is 1.3 (80 degrees centigrade), adds the fine drug powder that obtains, mixing, drying incapsulate after being ground into fine powder.Compared with prior art: the present invention has the effect of cholagogic and lithagogue, promoting blood circulation and stopping pain, be used for dampness-heat in the liver and gallbladder pent up due to cholecystitis, cholelithiasis; During use, oral capsule preparation, a 4-6 grain, three times on the one.The calculus grass that uses among the present invention originates in Guizhou Province as the dry herb of Radix campsis plant Westerner grass, and Herba Centipedae is that dry herb, the Rhizoma Corydalis of feverfew Herba Centipedae is the dry tuber of papaveraceae plant corydalis; The mechanism that the anti-in vivo masonry of this medicine is used is to improve bile acid concentration in the bile, cholesterol reducing, calcium and HCO
3 -Content reduces bilirubin and unconjugated bilirubin percentage rate, improves liver function; This product has killing action to escherichia coli and Bacillus typhi, streptococcus faecalis and staphylococcus aureus there is inhibitory action, can also obviously increase bile flow, reduce the acetic acid twisting reaction, for cholecystitis, cholelithiasis therapeutical effect is arranged, this medicine does not have toxic and side effects, and therapeutic effect is definite, cost is low, is easy to accept into the patient.
Embodiments of the invention 1: the method that water is carried extracts from 10 kilograms of calculus grass that the common process according to pharmacy is prepared into tablet with it after the active ingredients.
Embodiments of the invention 2: the method with alcohol extraction extracts the active ingredient that calculus grass 2000 grams, Herba Centipedae 100 restrain, and the common process according to pharmacy is prepared into medicinal oral preparation with it then.
Embodiments of the invention 3: the method that water is carried extracts the active ingredient of calculus grass 3500 grams, Herba Centipedae 200 grams, and the common process according to pharmacy is prepared into the pharmaceutical injection agent with it then.
Embodiments of the invention 4: the method that water is carried extracts the active ingredient of calculus grass 2000 grams, Herba Centipedae 100 grams, Rhizoma Corydalis 100 grams, and the common process according to pharmacy is prepared into granule with it then.
Embodiments of the invention 5: extract with the active ingredient with calculus grass 3500 grams, Herba Centipedae 200 grams, Rhizoma Corydalis gram 200 of the method for alcohol extraction, the common process according to pharmacy is prepared into pill with it then.
Embodiments of the invention 6: calculus grass 270 grams, Herba Centipedae 15 grams, Rhizoma Corydalis 15 grams are pulverized, sieved, standby, remaining calculus grass, Herba Centipedae, Rhizoma Corydalis are decocted with water three times, each 3 hours again, gradation filters, merging filtrate, being concentrated into relative density is 1.3 (80 degrees centigrade), adds the fine drug powder that obtains, mixing, drying incapsulate after being ground into fine powder.
Claims (6)
1, a kind of Chinese medicine preparation for the treatment of calculus and cholecystitis, it is characterized in that: it is made by following raw materials in weight portion: calculus grass 2000-3500, Herba Centipedae 100-200.
2, the Chinese medicine preparation of treatment calculus according to claim 1 and cholecystitis is characterized in that: wherein also can add Rhizoma Corydalis 100-200.
3, the Chinese medicine preparation of treatment calculus according to claim 2 and cholecystitis, it is characterized in that: wherein the weight proportion of each raw material is: calculus grass 2700 grams, Herba Centipedae 150 grams, Rhizoma Corydalis 150 grams.
4, the production method of the Chinese medicine preparation of treatment calculus according to claim 1 and cholecystitis is characterized in that: water or alcohol extraction calculus grass, Herba Centipedae, the common process according to pharmacy is prepared into medicinal oral preparation or injection with it then.
5, the production method of the Chinese medicine preparation of treatment calculus according to claim 2 and cholecystitis, it is characterized in that: water or alcohol extraction calculus grass, Herba Centipedae, Rhizoma Corydalis, the common process according to pharmacy is prepared into capsule, tablet, granule, pill, oral liquid with it then.
6, the production method of the Chinese medicine preparation of treatment calculus according to claim 3 and cholecystitis, it is characterized in that: calculus grass 270 grams, Herba Centipedae 15 grams, Rhizoma Corydalis 15 grams are pulverized, sieved, standby, remaining calculus grass, Herba Centipedae, Rhizoma Corydalis are decocted with water three times, each 3 hours again, gradation filters, merging filtrate, relative density is 1.3 when being concentrated into 80 degrees centigrade, add the fine drug powder obtain, mixing, drying incapsulate after being ground into fine powder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031175597A CN1179745C (en) | 2003-03-25 | 2003-03-25 | Chinese medicine preparation for curing choleithiasis and cholecystitis and production method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031175597A CN1179745C (en) | 2003-03-25 | 2003-03-25 | Chinese medicine preparation for curing choleithiasis and cholecystitis and production method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1454641A CN1454641A (en) | 2003-11-12 |
| CN1179745C true CN1179745C (en) | 2004-12-15 |
Family
ID=29260142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB031175597A Expired - Lifetime CN1179745C (en) | 2003-03-25 | 2003-03-25 | Chinese medicine preparation for curing choleithiasis and cholecystitis and production method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1179745C (en) |
-
2003
- 2003-03-25 CN CNB031175597A patent/CN1179745C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CN1454641A (en) | 2003-11-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee |
Owner name: GUIZHOU KANGNUO PHARMACEUTICAL CO., LTD. Free format text: FORMER NAME OR ADDRESS: ZHOU PINXI |
|
| CP03 | Change of name, title or address |
Address after: 550002, No. 16, building 2, Hang Seng building, new street, Guiyang, Guizhou Patentee after: Guizhou Kangnuo Pharmaceutical Co.,Ltd. Address before: 551700 Yingbin group, Yingbin street, Haizi Town, Guizhou, Bijie Patentee before: Zhou Pinxi |
|
| ASS | Succession or assignment of patent right |
Owner name: CHEN ZHANGYUN Free format text: FORMER OWNER: GUIZHOU KANGNUO PHARMACEUTICAL CO., LTD. Effective date: 20070525 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20070525 Address after: 550002, Guizhou, Guiyang province Nanming District No. 110 Patentee after: Chen Changyun Address before: 550002, No. 16, building 2, Hang Seng building, new street, Guiyang, Guizhou Patentee before: Guizhou Kangnuo Pharmaceutical Co.,Ltd. |
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| ASS | Succession or assignment of patent right |
Owner name: GUIZHOU ZHENGXIN PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: CHEN ZHANGYUN Effective date: 20110324 |
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| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 550002 NO. 110, HUINONG LANE, NANMING DISTRICT, GUIYANG CITY, GUIZHOU PROVINCE TO: 550009 CHANGBA INDUSTRIAL ZONE, XIAOHE DISTRICT, GUIYANG CITY, GUIZHOU PROVINCE |
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| TR01 | Transfer of patent right |
Effective date of registration: 20110324 Address after: 550009, Guizhou, Guiyang Province Creek District dam Industrial Zone Patentee after: GUIZHOU ZHENGXIN PHARMACEUTICAL Co.,Ltd. Address before: 550002, Guizhou, Guiyang province Nanming District No. 110 Patentee before: Chen Changyun |
|
| C56 | Change in the name or address of the patentee |
Owner name: GUIZHOU BAILING GROUP ZHENGXIN PHARMACEUTICAL CO., Free format text: FORMER NAME: GUIZHOU ZHENGXIN PHARMACEUTICAL CO., LTD. |
|
| CP01 | Change in the name or title of a patent holder |
Address after: 550009, Guizhou, Guiyang Province Creek District dam Industrial Zone Patentee after: Guizhou Bailing Enterprise Group Zhengxin Pharmaceutical Co.,Ltd. Address before: 550009, Guizhou, Guiyang Province Creek District dam Industrial Zone Patentee before: GUIZHOU ZHENGXIN PHARMACEUTICAL Co.,Ltd. |
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| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20041215 |