CN117944984A

CN117944984A - Embryo and ovum vitrification freezing carrier device for auxiliary reproduction

Info

Publication number: CN117944984A
Application number: CN202410164831.6A
Authority: CN
Inventors: 王健君; 高文姬
Original assignee: Songshan Lake Materials Laboratory
Current assignee: Songshan Lake Materials Laboratory
Priority date: 2024-02-05
Filing date: 2024-02-05
Publication date: 2024-04-30

Abstract

The invention provides an embryo and ovum vitrification freezing carrier device for auxiliary reproduction, which belongs to the technical field of cell vitrification freezing equipment and comprises the following components: a housing having a receiving compartment and a top opening, the top opening being provided with an openable closure; the pipe rack is arranged in the accommodating bin and is used for accommodating a plurality of cell collecting pipes; the lifting device is connected with the pipe frame and used for driving the pipe frame to move towards the top opening of the accommodating bin so that only the upper section part of the cell collecting pipe extends out of the top opening; the auxiliary reproduction embryo and ovum vitrification freezing carrier device is characterized in that a pipe frame is arranged in a containing bin through a lifting device, when a cell collecting pipe is taken, the pipe frame is lifted through the lifting device, only the upper section part of the cell collecting pipe extends out of the top opening of the containing bin, and the lower section part of the cell collecting pipe is continuously kept in the containing bin, so that other cell collecting pipes on the pipe frame cannot be heated too high when the cell collecting pipe is selected for a long time.

Description

Embryo and ovum vitrification freezing carrier device for auxiliary reproduction

Technical Field

The invention relates to the technical field of cell vitrification freezing equipment, in particular to an embryo and ovum vitrification freezing carrier device for auxiliary reproduction.

Background

The auxiliary reproduction technology is short for human auxiliary reproduction technology, and refers to technology for gestating sterile couples by adopting medical auxiliary means, and comprises two major technologies of artificial insemination, in vitro fertilization-embryo transplantation and derivative technology thereof. At present, in artificial assisted reproduction treatment, under the action of ovulation-promoting drugs, a plurality of ova can be obtained, and after in vitro fertilization, a plurality of embryos can be obtained, but only 1-3 embryos can be implanted when the embryos are implanted. In order to prevent conception failure or other reasons, the residual high-quality embryo or ovum is frozen and preserved, and the frozen embryo or ovum can be thawed, transplanted or fertilized in the next period, so that the utilization rate of the embryo and ovum is improved. Embryos are frozen at a temperature below-196 ℃ and stopped from developing and can be stored for years.

In the prior art, a plurality of cell collecting pipes are generally placed on a pipe rack, the pipe rack is placed in a liquid nitrogen tank, the cell collecting pipes are immersed in liquid nitrogen, and then embryos are frozen at a temperature of minus 196 ℃.

However, when the cell collecting pipes are taken out of the liquid nitrogen tank, the pipe frame is required to be taken out of the liquid nitrogen tank, all the cell collecting pipes are required to be completely separated from the liquid nitrogen tank, and then the required cell collecting pipes are found out.

Disclosure of Invention

Therefore, the technical problem to be solved by the invention is to overcome the defect that the temperature of the rest of the cell collecting pipes is easily increased to cause irreversible damage because all the cell collecting pipes need to be completely separated from a liquid nitrogen tank when the cell collecting pipes are searched by the refrigeration equipment in the prior art, thereby providing an embryo and ovum vitrification freezing carrier device for auxiliary reproduction.

In order to solve the technical problems, the invention provides an embryo and ovum vitrification freezing carrier device for auxiliary reproduction, comprising:

a housing having a receiving compartment with a top opening, the top opening being provided with an openable closure;

the pipe rack is arranged in the accommodating bin and is used for accommodating a plurality of cell collecting pipes;

And the lifting device is connected with the pipe frame and is used for driving the pipe frame to move towards the top opening of the accommodating bin so that only the upper section part of the cell collecting pipe extends out of the top opening.

Optionally, the shell comprises a shell and an inner container, and an interlayer suitable for being set to negative pressure is arranged between the shell and the inner container.

Optionally, the shell is steel material, the inner bag is aluminum alloy material, the shell with connect through the bracing piece that a plurality of intervals set up between the inner bag.

Optionally, the shell is provided with a vacuumizing hole and a pressure gauge which are communicated with the interlayer.

Optionally, a one-way valve for pumping air outwards in one way is arranged on the vacuumizing hole.

Optionally, the method further comprises: the base has the holding tank that the opening was up, the casing sets up in the holding tank of base, the interior bottom wall of holding tank with be provided with vertical bradyseism subassembly between the casing, the inside wall of holding tank with be provided with horizontal bradyseism subassembly between the casing.

Optionally, a rubber pad is arranged at the bottom of the base.

Optionally, the longitudinal cushioning assembly includes: the rolling device comprises a shell body, a first elastic piece, an arc-shaped shell and a rolling ball, wherein the upper end of the first elastic piece is connected with the arc-shaped shell, the arc-shaped shell is supported below the rolling ball, the first elastic piece has elastic supporting force for supporting the rolling ball, and the rolling ball can be rollably supported at the bottom of the shell body.

Optionally, the transverse cushioning member comprises: the ball end of the ball slide rod is abutted to the side wall of the shell, and the second elastic piece is provided with elastic force for driving the ball slide rod to face the shell in an abutting mode.

Optionally, the lifting device is connected with the pipe rack through a vertical screw rod, and the vertical screw rod is provided with at least two symmetrically arranged.

Optionally, the lifting device includes: the driving wheel is rotationally connected to the accommodating bin, is matched with the vertical screw rod through threads, and is rotationally driven to lift the vertical screw rod.

Optionally, the driving wheels are provided with a plurality of driving wheels which are arranged around the top opening of the accommodating bin at intervals, the driving wheels are connected through a transmission belt, and at least one driving wheel is provided with an operating handle.

The technical scheme of the invention has the following advantages:

1. The invention provides an embryo and ovum vitrification freezing carrier device for auxiliary reproduction, wherein a pipe frame for arranging a cell collecting pipe is arranged in a containing bin through a lifting device, when the cell collecting pipe is taken, the pipe frame is lifted through the lifting device, only the upper section part of the cell collecting pipe extends out of the top opening of the containing bin, and the lower section part of the cell collecting pipe is continuously kept in the containing bin, so that other cell collecting pipes on the pipe frame can not be heated too high when the cell collecting pipe is selected for a long time.

2. According to the embryo and ovum vitrification freezing carrier device for auxiliary reproduction, provided by the invention, the negative pressure is arranged through the interlayer between the inner container and the outer shell, so that the heat preservation effect of the inner container is further improved, and the low-temperature state in the inner container is ensured to be more durable.

3. The embryo and ovum vitrification freezing carrier device for auxiliary reproduction provided by the invention can reduce the vibration of the shell as much as possible in the running process through the arrangement of the base.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings that are needed in the description of the embodiments or the prior art will be briefly described, and it is obvious that the drawings in the description below are some embodiments of the present invention, and other drawings can be obtained according to the drawings without inventive effort for a person skilled in the art.

FIG. 1 is a front cross-sectional view of one embodiment of an auxiliary reproductive embryo and ovum vitrification freezing vector device provided in an example of the present invention;

FIG. 2 is a front view of FIG. 1;

FIG. 3 is an enlarged view of area a of FIG. 1;

FIG. 4 is an enlarged view of region b of FIG. 1;

FIG. 5 is an enlarged view of region c of FIG. 1;

fig. 6 is a top view of the lift assembly of fig. 1.

Reference numerals illustrate:

1. A base; 2. a housing;

3. a longitudinal shock absorbing assembly; 301. a first elastic member; 302. an arc-shaped shell; 303. a rolling ball;

4. a horizontal cushioning assembly; 401. a second elastic member; 402. a ball head slide bar;

5. an inner container; 501. a top opening; 502. a support rod;

6. A vacuum hole;

7. A lifting assembly; 701. a support tube; 702. a driving wheel; 703. a vertical screw; 704. a transmission belt; 705. an operation handle;

8. A bottom plate; 9. a perforated plate; 10. a cell collection tube; 11. a pressure gauge; 12. a cover; 13. a cover body; 14. insulating foam blocks; 15. and a rubber pad.

Detailed Description

The following description of the embodiments of the present invention will be made apparent and fully in view of the accompanying drawings, in which some, but not all embodiments of the invention are shown. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.

In the description of the present invention, it should be noted that the directions or positional relationships indicated by the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. are based on the directions or positional relationships shown in the drawings, are merely for convenience of describing the present invention and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a specific orientation, be configured and operated in a specific orientation, and thus should not be construed as limiting the present invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.

In the description of the present invention, it should be noted that, unless explicitly specified and limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be either fixedly connected, detachably connected, or integrally connected, for example; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present invention can be understood by those of ordinary skill in the art according to the specific circumstances.

In addition, the technical features of the different embodiments of the present invention described below may be combined with each other as long as they do not collide with each other.

As shown in fig. 1, a specific embodiment of the auxiliary reproduction embryo and ovum vitrification frozen carrier device provided in this embodiment includes: a housing 2, a pipe rack and a lifting device, wherein the housing 2 is provided with a containing bin, the containing bin is provided with a top opening 501, and an openable sealing cover 12 is arranged on the top opening 501; the pipe frame is arranged in the accommodating bin, and a plurality of cell collecting pipes 10 can be placed on the pipe frame; the lifting device is connected with the pipe frame and is used for driving the pipe frame to move towards the top opening 501 of the accommodating bin so that the upper section part of the cell collecting pipe 10 extends out of the top opening 501. Specifically, the shape of the top opening 501 is adapted to the shape of the pipe rack, and may be, for example, a circular hole or a square hole. The lifting device may be a cylinder, an oil cylinder, an electric push rod, a manual lifting device, or the like, and is not particularly limited in this embodiment. In addition, it may further include: the cover body 13, the rotatable setting of cover body 13 is in the top of casing 2 also can direct lock be in the top of casing 2, be provided with the heat preservation foam piece 14 that is used for thermal-insulated in the cover body 13, the heat preservation foam piece 14 is last to have and is used for keeping away the recess of position elevating gear. Through the setting of lid 13 can be favorable to holding the heat preservation at storehouse top more, in addition, when setting up behind the lid 13, closing cap 12 with hold and set up the cooperation that just leaves certain gap between the open-top 501 in storehouse, be convenient for hold the discharge after the liquid nitrogen volatilizees in the storehouse, the material of closing cap 12 can be polyurethane foam.

The auxiliary reproduction embryo and ovum vitrification freezing carrier device provided by the embodiment is characterized in that the pipe frame for arranging the cell collecting pipe 10 is arranged in the accommodating bin through the lifting device, when the cell collecting pipe 10 is taken, the pipe frame is lifted through the lifting device, only the upper section part of the cell collecting pipe 10 extends out of the top opening 501 of the accommodating bin, and the lower section part of the cell collecting pipe 10 is continuously kept in the accommodating bin, so that when the cell collecting pipe 10 is selected for a long time, other cell collecting pipes 10 on the pipe frame cannot be heated too high.

As shown in fig. 1, in the auxiliary reproduction embryo and ovum vitrification freezing carrier device provided in this embodiment, the casing 2 includes a housing and an inner container 5, the inner container 5 is disposed inside the housing, and an interlayer suitable for being set to negative pressure is disposed between the inner container 5 and the housing. Specifically, the casing 2 and the liner 5 are fixedly connected at the top, the liner 5 extends downward to the inside of the casing 2, and maintains a space with the inner wall of the casing 2 to form the interlayer, and the interlayer is connected between the casing 2 and the inner wall through a plurality of support rods 502 arranged at intervals. When in use, negative pressure is arranged through the interlayer between the inner container 5 and the outer shell, so that the heat preservation effect of the inner container 5 is further improved, and the low-temperature state in the inner container 5 is ensured to be more durable.

As shown in fig. 1, the inner container 5 is made of aluminum alloy, and is internally adapted to be provided with liquid nitrogen when in use, so as to keep the cell collecting tube 10 at a low temperature.

As shown in fig. 2, the casing is made of steel, and is provided with a vacuumizing hole 6 and a pressure gauge 11 which are communicated with the interlayer. During operation, the interlayer is set to be negative pressure through the vacuumizing hole 6, and the negative pressure state of the interlayer is monitored through the pressure gauge 11, so that the heat preservation effect on the liner 5 is ensured.

As shown in fig. 2, the vacuumizing hole 6 is provided with a one-way valve for pumping air outwards in a one-way, and the convenience in vacuumizing is improved through the arrangement of the one-way valve.

As shown in fig. 1, the auxiliary reproduction embryo and ovum vitrification frozen carrier device provided in this embodiment further includes: the base 1, base 1 has the holding tank that the opening was up, casing 2 sets up in the holding tank of base 1, the interior diapire of holding tank with be provided with vertical bradyseism subassembly 3 between the casing 2, the inside wall of holding tank with be provided with horizontal bradyseism subassembly between the casing 2. By providing the base 1, the vibration of the housing 2 can be reduced as much as possible during operation. Of course, in some alternative embodiments, the base 1 may be omitted.

As shown in fig. 1, in the embryo and ovum vitrification freezing carrier device for auxiliary reproduction provided in this embodiment, a rubber pad 15 is provided at the bottom of the base 1, and the rubber pad 15 contacts with the bottom surface, so that the vibration-proof and anti-slip effects on the base 1 can be improved.

As shown in fig. 1 and 3, in the auxiliary reproduction embryo and ovum vitrification frozen carrier device provided in this embodiment, the longitudinal shock absorbing member 3 includes: the rolling device comprises a first elastic piece 301, an arc-shaped shell 302 and a rolling ball 303, wherein the upper end of the first elastic piece 301 is connected with the arc-shaped shell 302, the arc-shaped shell 302 is supported below the rolling ball 303, the first elastic piece 301 has elastic supporting force for supporting the rolling ball 303, and the rolling ball 303 is rollably supported at the bottom of the shell 2. Specifically, the first elastic member 301 may be a spring. The longitudinal shock absorbing assembly 3 is provided with four groups distributed in four corners on the inner bottom wall of the accommodating groove of the base 1. When in use, the four groups of rolling balls 303 are respectively abutted against four corners of the bottom of the shell 2, and in the running process, the shell 2 can slide on the rolling balls 303 along the horizontal direction, and the arrangement of the arc-shaped shell 302 can improve the rolling flexibility of the rolling balls 303.

As shown in fig. 1 and 4, in the auxiliary reproduction embryo and ovum vitrification frozen carrier device provided in this embodiment, the transverse shock absorbing member includes: the ball-end of the ball-end sliding rod 402 is abutted to the side wall of the shell 2, and the second elastic piece 401 has elastic force for driving the ball-end sliding rod 402 to be abutted to the shell 2. In particular, the second elastic member 401 may be a spring. When in use, the ball end of the ball head slide bar 402 is abutted against the side wall of the shell 2, and in the running process, the shell 2 can slide along the vertical direction on the ball end of the ball head slide bar 402, and the slidability between the arc-shaped ball end and the side wall of the shell 2 can be improved.

As shown in fig. 1 and 5, in the auxiliary reproduction embryo and ovum vitrification freezing carrier device provided in this embodiment, the lifting device is connected with the pipe rack through a vertical screw 703, and the vertical screw 703 has at least two symmetrically arranged screws. Through the vertical screw 703 of symmetry setting, can be steady connect the pipe support to carry out steady lift to the pipe support. Specifically, the pipe rack comprises a bottom plate 8 and a perforated plate 9 arranged above the bottom plate 8 at intervals in parallel, wherein a plurality of through holes for penetrating through the cell collecting pipe 10 are formed in the perforated plate 9, and the bottom plate 8 is used for receiving the bottom end of the cell collecting pipe 10; the bottom plate 8 and the perforated plate 9 are connected through a plurality of vertical rods, and at least part of the vertical rods extend upwards to be connected with the vertical screw 703. In this embodiment, the lifting device lifts the pipe rack through a plurality of vertical screws 703, and in some alternative embodiments, the lifting device may also lift the pipe rack through cooperation of an air cylinder, an oil cylinder or an electric push rod with a guide rod.

As shown in fig. 6, in the auxiliary reproduction embryo and ovum vitrification frozen carrier device provided in the present embodiment, the lifting device includes: the driving wheel 702 is rotatably connected to the accommodating bin, the driving wheel 702 is in threaded fit with the vertical screw 703, and the driving wheel 702 drives the vertical screw 703 to lift through rotation. Specifically, a supporting pipe 701 is vertically arranged at the top of the accommodating bin, the driving wheel 702 is rotatably connected to the top end of the supporting pipe 701, the vertical screw 703 passes through the supporting pipe 701 and is in threaded fit with the driving wheel 702, and when the driving wheel 702 rotates on the supporting pipe 701, the vertical screw 703 can be driven to lift. The driving wheel 702 is provided with a plurality of driving wheels 702 which are arranged around the top opening 501 of the accommodating bin at intervals, the plurality of driving wheels 702 are connected through a transmission belt 704, an operating handle 705 is arranged on one driving wheel 702, and the diameter of the driving wheel 702 provided with the operating handle 705 is larger, so that the rotating force can be applied more in a labor-saving way.

Application method

In the auxiliary reproduction embryo and ovum vitrification freezing carrier device provided by the embodiment, when in use, as shown in figure 1, the cover body 13 is firstly opened to expose the liner 5 in the shell 2 and the lifting device thereon; as shown in fig. 6, the cover 12 on the liner 5 is opened, the operating handle 705 of the lifting device is rotated, and the vertical screw 703 is raised by the synchronous rotation of the plurality of driving wheels 702, thereby raising the pipe rack. When the pipe frame is lifted to enable the upper section of the cell collecting pipe 10 to extend out of the top opening 501 of the inner container 5, the required cell collecting pipe 10 is clamped by long tweezers, in the process, the cell collecting pipe 10 cannot completely leave the inner container 5, and the temperature cannot be raised too fast in the process of searching the cell collecting pipe 10.

It is apparent that the above examples are given by way of illustration only and are not limiting of the embodiments. Other variations or modifications of the above teachings will be apparent to those of ordinary skill in the art. It is not necessary here nor is it exhaustive of all embodiments. And obvious variations or modifications thereof are contemplated as falling within the scope of the present invention.

Claims

1. An assisted reproductive embryo and ovum vitrification frozen carrier device, comprising:

a housing (2) having a receiving compartment with a top opening (501), said top opening (501) being provided with an openable closure (12);

a pipe rack arranged in the accommodating bin, wherein the pipe rack is used for accommodating a plurality of cell collecting pipes (10);

And the lifting device is connected with the pipe frame and is used for driving the pipe frame to move towards the top opening (501) of the accommodating bin so that only the upper section part of the cell collecting pipe (10) extends out of the top opening (501).

2. Auxiliary reproduction embryo and ovum vitrification freezing carrier device according to claim 1, characterized in that the housing (2) comprises an outer shell and an inner container (5), between which outer shell and the inner container (5) there is an interlayer adapted to be set to negative pressure.

3. The embryo and ovum vitrification freezing carrier device for auxiliary reproduction according to claim 2, wherein the outer shell is made of steel material, the inner container (5) is made of aluminum alloy material, and the outer shell and the inner container (5) are connected through a plurality of support rods (502) arranged at intervals.

4. An auxiliary reproduction embryo and ovum vitrification frozen carrier device according to claim 3, characterized in that the outer shell is provided with a vacuum-pumping hole (6) and a pressure gauge (11) which are communicated with the interlayer.

5. The auxiliary reproduction embryo and ovum vitrification frozen carrier device as set forth in claim 4, wherein a one-way valve for pumping air outwards in one way is arranged on the vacuumizing hole (6).

6. The assisted reproductive embryo and ovum vitrification frozen carrier device as set forth in claim 1, further comprising: base (1) has the holding tank of opening up, casing (2) set up in the holding tank of base (1), the interior bottom wall of holding tank with be provided with vertical bradyseism subassembly (3) between casing (2), the inside wall of holding tank with be provided with horizontal bradyseism subassembly between casing (2).

7. Auxiliary reproduction embryo and ovum vitrification frozen carrier device according to claim 6, characterized in that the bottom of the base (1) is provided with a rubber pad (15).

8. Auxiliary reproduction embryo and ovum vitrification frozen carrier device according to claim 6, characterized in that the longitudinal shock absorbing member (3) comprises: the novel rolling device comprises a first elastic piece (301), an arc-shaped shell (302) and a rolling ball (303), wherein the upper end of the first elastic piece (301) is connected with the arc-shaped shell (302), the arc-shaped shell (302) is supported below the rolling ball (303), the first elastic piece (301) has elastic supporting force for supporting the rolling ball (303), and the rolling ball (303) is rollably supported at the bottom of the shell (2).

9. The assisted reproductive embryo and ovum vitrification frozen carrier device as set forth in claim 6, wherein the lateral shock absorbing assembly includes: the ball head sliding rod comprises a first elastic piece (401) and a ball head sliding rod (402), wherein one end of the first elastic piece (401) is connected with the ball head sliding rod (402), the ball head end of the ball head sliding rod (402) is abutted to the side wall of the shell (2), and the first elastic piece (401) has elastic force for driving the ball head sliding rod (402) to face the shell (2) in an abutted mode.

10. Auxiliary reproduction embryo and ovum vitrification freezing vector device according to any of claims 1-9, characterized in that the lifting device is connected to the tube rack by means of a vertical screw (703), the vertical screw (703) having at least two symmetrically arranged.

11. The auxiliary reproductive embryo and ovum vitrification freezing vector device as set forth in claim 10, wherein the elevating device comprises: the driving wheel (702) is rotatably connected to the accommodating bin, the driving wheel (702) is in threaded fit with the vertical screw (703), and the driving wheel (702) drives the vertical screw (703) to lift through rotation.

12. Auxiliary reproduction embryo and ovum vitrification frozen carrier device according to claim 11, characterized in that the driving wheel (702) has a plurality of spaced around the top opening (501) of the holding compartment, a plurality of the driving wheels (702) are connected by a transmission belt (704), at least one driving wheel (702) is provided with an operating handle (705).