CN117881446A - 注入器装置部件表面修改 - Google Patents
注入器装置部件表面修改 Download PDFInfo
- Publication number
- CN117881446A CN117881446A CN202180101884.8A CN202180101884A CN117881446A CN 117881446 A CN117881446 A CN 117881446A CN 202180101884 A CN202180101884 A CN 202180101884A CN 117881446 A CN117881446 A CN 117881446A
- Authority
- CN
- China
- Prior art keywords
- stopper
- injection
- syringe
- barrier
- injector device
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000004048 modification Effects 0.000 title description 43
- 238000012986 modification Methods 0.000 title description 43
- 230000033001 locomotion Effects 0.000 claims abstract description 94
- 238000000034 method Methods 0.000 claims abstract description 57
- 238000004519 manufacturing process Methods 0.000 claims abstract description 25
- 239000000463 material Substances 0.000 claims description 148
- 230000004888 barrier function Effects 0.000 claims description 131
- 238000007789 sealing Methods 0.000 claims description 93
- 229920002313 fluoropolymer Polymers 0.000 claims description 37
- 239000004811 fluoropolymer Substances 0.000 claims description 37
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims description 30
- 239000004810 polytetrafluoroethylene Substances 0.000 claims description 30
- 229920000642 polymer Polymers 0.000 claims description 12
- 238000012546 transfer Methods 0.000 claims description 11
- 230000002708 enhancing effect Effects 0.000 claims description 10
- 238000010438 heat treatment Methods 0.000 claims description 10
- 230000002829 reductive effect Effects 0.000 claims description 10
- 230000001939 inductive effect Effects 0.000 claims description 8
- 230000009467 reduction Effects 0.000 claims description 7
- 239000007924 injection Substances 0.000 description 333
- 238000002347 injection Methods 0.000 description 333
- 229940090044 injection Drugs 0.000 description 328
- 239000010410 layer Substances 0.000 description 100
- 210000004027 cell Anatomy 0.000 description 78
- 229960005486 vaccine Drugs 0.000 description 42
- 230000007547 defect Effects 0.000 description 35
- 102000005962 receptors Human genes 0.000 description 34
- 108020003175 receptors Proteins 0.000 description 34
- 102000001805 Bromodomains Human genes 0.000 description 33
- -1 polytetrafluoroethylene Polymers 0.000 description 33
- 108050009021 Bromodomains Proteins 0.000 description 28
- 108091000080 Phosphotransferase Proteins 0.000 description 25
- 102000020233 phosphotransferase Human genes 0.000 description 25
- 108090000623 proteins and genes Proteins 0.000 description 24
- 235000018102 proteins Nutrition 0.000 description 20
- 102000004169 proteins and genes Human genes 0.000 description 20
- 230000037303 wrinkles Effects 0.000 description 18
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 16
- 230000007246 mechanism Effects 0.000 description 16
- 239000011734 sodium Substances 0.000 description 16
- 229910052708 sodium Inorganic materials 0.000 description 16
- 239000000725 suspension Substances 0.000 description 15
- 239000004812 Fluorinated ethylene propylene Substances 0.000 description 13
- 108700020796 Oncogene Proteins 0.000 description 13
- 238000003780 insertion Methods 0.000 description 13
- 230000037431 insertion Effects 0.000 description 13
- 229920009441 perflouroethylene propylene Polymers 0.000 description 13
- 238000012545 processing Methods 0.000 description 13
- 102000001253 Protein Kinase Human genes 0.000 description 12
- 239000007788 liquid Substances 0.000 description 12
- 230000001225 therapeutic effect Effects 0.000 description 12
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 description 11
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 description 11
- 238000005259 measurement Methods 0.000 description 11
- 229960001972 panitumumab Drugs 0.000 description 11
- 108060006633 protein kinase Proteins 0.000 description 11
- 239000000126 substance Substances 0.000 description 11
- 239000002131 composite material Substances 0.000 description 10
- 229920001577 copolymer Polymers 0.000 description 10
- 210000000056 organ Anatomy 0.000 description 10
- 230000008569 process Effects 0.000 description 10
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 9
- 230000000694 effects Effects 0.000 description 9
- 229920001971 elastomer Polymers 0.000 description 9
- 108090000765 processed proteins & peptides Proteins 0.000 description 9
- BFKJFAAPBSQJPD-UHFFFAOYSA-N tetrafluoroethene Chemical group FC(F)=C(F)F BFKJFAAPBSQJPD-UHFFFAOYSA-N 0.000 description 9
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 8
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 8
- 229940022663 acetate Drugs 0.000 description 8
- 239000011324 bead Substances 0.000 description 8
- 238000010276 construction Methods 0.000 description 8
- 239000003814 drug Substances 0.000 description 8
- 210000002919 epithelial cell Anatomy 0.000 description 8
- 210000004907 gland Anatomy 0.000 description 8
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 8
- 210000004379 membrane Anatomy 0.000 description 8
- 239000012528 membrane Substances 0.000 description 8
- GRVOTVYEFDAHCL-RTSZDRIGSA-N morphine sulfate pentahydrate Chemical compound O.O.O.O.O.OS(O)(=O)=O.O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O.O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O GRVOTVYEFDAHCL-RTSZDRIGSA-N 0.000 description 8
- 210000002569 neuron Anatomy 0.000 description 8
- 239000002245 particle Substances 0.000 description 8
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 7
- 241000282414 Homo sapiens Species 0.000 description 7
- 101001059454 Homo sapiens Serine/threonine-protein kinase MARK2 Proteins 0.000 description 7
- 102000002265 Human Growth Hormone Human genes 0.000 description 7
- 108010000521 Human Growth Hormone Proteins 0.000 description 7
- 239000000854 Human Growth Hormone Substances 0.000 description 7
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 7
- 108010029485 Protein Isoforms Proteins 0.000 description 7
- 102000001708 Protein Isoforms Human genes 0.000 description 7
- 102100028904 Serine/threonine-protein kinase MARK2 Human genes 0.000 description 7
- 239000008121 dextrose Substances 0.000 description 7
- 239000011521 glass Substances 0.000 description 7
- 229940102213 injectable suspension Drugs 0.000 description 7
- 239000005060 rubber Substances 0.000 description 7
- 230000003248 secreting effect Effects 0.000 description 7
- 108010001127 Insulin Receptor Proteins 0.000 description 6
- QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 description 6
- 229910052770 Uranium Inorganic materials 0.000 description 6
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 6
- 238000011049 filling Methods 0.000 description 6
- GMVPRGQOIOIIMI-DWKJAMRDSA-N prostaglandin E1 Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O GMVPRGQOIOIIMI-DWKJAMRDSA-N 0.000 description 6
- 230000003746 surface roughness Effects 0.000 description 6
- XRASPMIURGNCCH-UHFFFAOYSA-N zoledronic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CN1C=CN=C1 XRASPMIURGNCCH-UHFFFAOYSA-N 0.000 description 6
- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 description 5
- 108091005575 Bromodomain-containing proteins Proteins 0.000 description 5
- UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 description 5
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 5
- 108010051696 Growth Hormone Proteins 0.000 description 5
- 102000003746 Insulin Receptor Human genes 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
- 102100038803 Somatotropin Human genes 0.000 description 5
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 5
- 102100033782 UDP-galactose translocator Human genes 0.000 description 5
- 108010059993 Vancomycin Proteins 0.000 description 5
- 241000700605 Viruses Species 0.000 description 5
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 5
- 229960000548 alemtuzumab Drugs 0.000 description 5
- 229940024606 amino acid Drugs 0.000 description 5
- 150000001413 amino acids Chemical class 0.000 description 5
- 210000000270 basal cell Anatomy 0.000 description 5
- 229960005395 cetuximab Drugs 0.000 description 5
- 239000003792 electrolyte Substances 0.000 description 5
- XTULMSXFIHGYFS-VLSRWLAYSA-N fluticasone furoate Chemical compound O([C@]1([C@@]2(C)C[C@H](O)[C@]3(F)[C@@]4(C)C=CC(=O)C=C4[C@@H](F)C[C@H]3[C@@H]2C[C@H]1C)C(=O)SCF)C(=O)C1=CC=CO1 XTULMSXFIHGYFS-VLSRWLAYSA-N 0.000 description 5
- PIZALBORPSCYJU-QSQMUHTISA-H gadofosveset Chemical compound O.[Na+].[Na+].[Na+].[Gd+3].C1CC(OP([O-])(=O)OC[C@@H](CN(CCN(CC([O-])=O)CC([O-])=O)CC(=O)[O-])N(CC([O-])=O)CC([O-])=O)CCC1(C=1C=CC=CC=1)C1=CC=CC=C1 PIZALBORPSCYJU-QSQMUHTISA-H 0.000 description 5
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 5
- 229960003297 gemtuzumab ozogamicin Drugs 0.000 description 5
- 239000000122 growth hormone Substances 0.000 description 5
- 229940088597 hormone Drugs 0.000 description 5
- 239000005556 hormone Substances 0.000 description 5
- 239000002502 liposome Substances 0.000 description 5
- 229960004715 morphine sulfate Drugs 0.000 description 5
- 229940067082 pentetate Drugs 0.000 description 5
- 102000014187 peptide receptors Human genes 0.000 description 5
- 108010011903 peptide receptors Proteins 0.000 description 5
- 239000008194 pharmaceutical composition Substances 0.000 description 5
- 229920001296 polysiloxane Polymers 0.000 description 5
- 210000002248 primary sensory neuron Anatomy 0.000 description 5
- 230000001105 regulatory effect Effects 0.000 description 5
- 229960004641 rituximab Drugs 0.000 description 5
- 229920002545 silicone oil Polymers 0.000 description 5
- 229910052725 zinc Inorganic materials 0.000 description 5
- 239000011701 zinc Substances 0.000 description 5
- METKIMKYRPQLGS-GFCCVEGCSA-N (R)-atenolol Chemical compound CC(C)NC[C@@H](O)COC1=CC=C(CC(N)=O)C=C1 METKIMKYRPQLGS-GFCCVEGCSA-N 0.000 description 4
- ITPDYQOUSLNIHG-UHFFFAOYSA-N Amiodarone hydrochloride Chemical compound [Cl-].CCCCC=1OC2=CC=CC=C2C=1C(=O)C1=CC(I)=C(OCC[NH+](CC)CC)C(I)=C1 ITPDYQOUSLNIHG-UHFFFAOYSA-N 0.000 description 4
- 102100023995 Beta-nerve growth factor Human genes 0.000 description 4
- 102000019034 Chemokines Human genes 0.000 description 4
- 108010012236 Chemokines Proteins 0.000 description 4
- 102100030013 Endoribonuclease Human genes 0.000 description 4
- 108010079345 Follicle Stimulating Hormone Proteins 0.000 description 4
- 102000012673 Follicle Stimulating Hormone Human genes 0.000 description 4
- 108010072051 Glatiramer Acetate Proteins 0.000 description 4
- 108060003199 Glucagon Proteins 0.000 description 4
- 102000051325 Glucagon Human genes 0.000 description 4
- 101000640793 Homo sapiens UDP-galactose translocator Proteins 0.000 description 4
- PCIOHQNIRPWFMV-WXXKFALUSA-N Ibutilide fumarate Chemical compound OC(=O)\C=C\C(O)=O.CCCCCCCN(CC)CCCC(O)C1=CC=C(NS(C)(=O)=O)C=C1.CCCCCCCN(CC)CCCC(O)C1=CC=C(NS(C)(=O)=O)C=C1 PCIOHQNIRPWFMV-WXXKFALUSA-N 0.000 description 4
- XDXDZDZNSLXDNA-TZNDIEGXSA-N Idarubicin Chemical compound C1[C@H](N)[C@H](O)[C@H](C)O[C@H]1O[C@@H]1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2C[C@@](O)(C(C)=O)C1 XDXDZDZNSLXDNA-TZNDIEGXSA-N 0.000 description 4
- 102000051628 Interleukin-1 receptor antagonist Human genes 0.000 description 4
- 108700021006 Interleukin-1 receptor antagonist Proteins 0.000 description 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 4
- 102000043136 MAP kinase family Human genes 0.000 description 4
- 108091054455 MAP kinase family Proteins 0.000 description 4
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 description 4
- 108010025020 Nerve Growth Factor Proteins 0.000 description 4
- 239000002033 PVDF binder Substances 0.000 description 4
- 229920001774 Perfluoroether Polymers 0.000 description 4
- 239000004698 Polyethylene Substances 0.000 description 4
- 239000004743 Polypropylene Substances 0.000 description 4
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 4
- 102000009516 Protein Serine-Threonine Kinases Human genes 0.000 description 4
- 108010009341 Protein Serine-Threonine Kinases Proteins 0.000 description 4
- LOUPRKONTZGTKE-WZBLMQSHSA-N Quinine Chemical compound C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-WZBLMQSHSA-N 0.000 description 4
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 4
- 108010009978 Tec protein-tyrosine kinase Proteins 0.000 description 4
- GKLVYJBZJHMRIY-OUBTZVSYSA-N Technetium-99 Chemical compound [99Tc] GKLVYJBZJHMRIY-OUBTZVSYSA-N 0.000 description 4
- 102100038126 Tenascin Human genes 0.000 description 4
- 108010008125 Tenascin Proteins 0.000 description 4
- 108010050144 Triptorelin Pamoate Proteins 0.000 description 4
- NIJJYAXOARWZEE-UHFFFAOYSA-N Valproic acid Chemical compound CCCC(C(O)=O)CCC NIJJYAXOARWZEE-UHFFFAOYSA-N 0.000 description 4
- 210000001130 astrocyte Anatomy 0.000 description 4
- 229960002274 atenolol Drugs 0.000 description 4
- 230000008859 change Effects 0.000 description 4
- 238000000748 compression moulding Methods 0.000 description 4
- 230000007423 decrease Effects 0.000 description 4
- 230000001419 dependent effect Effects 0.000 description 4
- GQPXYJNXTAFDLT-UHFFFAOYSA-L disodium;(2,5-dioxo-4,4-diphenylimidazolidin-1-yl)methyl phosphate Chemical compound [Na+].[Na+].O=C1N(COP([O-])(=O)[O-])C(=O)NC1(C=1C=CC=CC=1)C1=CC=CC=C1 GQPXYJNXTAFDLT-UHFFFAOYSA-L 0.000 description 4
- AVAACINZEOAHHE-VFZPANTDSA-N doripenem Chemical compound C=1([C@H](C)[C@@H]2[C@H](C(N2C=1C(O)=O)=O)[C@H](O)C)S[C@@H]1CN[C@H](CNS(N)(=O)=O)C1 AVAACINZEOAHHE-VFZPANTDSA-N 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 229940082789 erbitux Drugs 0.000 description 4
- HQQADJVZYDDRJT-UHFFFAOYSA-N ethene;prop-1-ene Chemical group C=C.CC=C HQQADJVZYDDRJT-UHFFFAOYSA-N 0.000 description 4
- 229920000295 expanded polytetrafluoroethylene Polymers 0.000 description 4
- 210000002950 fibroblast Anatomy 0.000 description 4
- 239000000945 filler Substances 0.000 description 4
- VRQHBYGYXDWZDL-OOZCZQCLSA-N fosaprepitant dimeglumine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.O([C@@H]([C@@H]1C=2C=CC(F)=CC=2)O[C@H](C)C=2C=C(C=C(C=2)C(F)(F)F)C(F)(F)F)CCN1CC1=NN(P(O)(O)=O)C(=O)N1 VRQHBYGYXDWZDL-OOZCZQCLSA-N 0.000 description 4
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 description 4
- 229960004666 glucagon Drugs 0.000 description 4
- 238000009499 grossing Methods 0.000 description 4
- 239000003102 growth factor Substances 0.000 description 4
- 230000002209 hydrophobic effect Effects 0.000 description 4
- 229960000905 indomethacin Drugs 0.000 description 4
- 238000001802 infusion Methods 0.000 description 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 4
- 238000001990 intravenous administration Methods 0.000 description 4
- GURKHSYORGJETM-WAQYZQTGSA-N irinotecan hydrochloride (anhydrous) Chemical compound Cl.C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 GURKHSYORGJETM-WAQYZQTGSA-N 0.000 description 4
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N iron oxide Inorganic materials [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 4
- 210000002510 keratinocyte Anatomy 0.000 description 4
- 230000000670 limiting effect Effects 0.000 description 4
- 229940118179 lovenox Drugs 0.000 description 4
- 239000000314 lubricant Substances 0.000 description 4
- 239000010687 lubricating oil Substances 0.000 description 4
- 239000011159 matrix material Substances 0.000 description 4
- 238000002844 melting Methods 0.000 description 4
- 230000008018 melting Effects 0.000 description 4
- 229960000485 methotrexate Drugs 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 229960002009 naproxen Drugs 0.000 description 4
- 229940053128 nerve growth factor Drugs 0.000 description 4
- 210000004498 neuroglial cell Anatomy 0.000 description 4
- 229920003023 plastic Polymers 0.000 description 4
- 239000004033 plastic Substances 0.000 description 4
- 229920000052 poly(p-xylylene) Polymers 0.000 description 4
- 229920000573 polyethylene Polymers 0.000 description 4
- 229920001155 polypropylene Polymers 0.000 description 4
- 229920002981 polyvinylidene fluoride Polymers 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 102000003998 progesterone receptors Human genes 0.000 description 4
- 108090000468 progesterone receptors Proteins 0.000 description 4
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 4
- 239000002356 single layer Substances 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 210000000130 stem cell Anatomy 0.000 description 4
- 230000008093 supporting effect Effects 0.000 description 4
- 229910052713 technetium Inorganic materials 0.000 description 4
- GKLVYJBZJHMRIY-UHFFFAOYSA-N technetium atom Chemical compound [Tc] GKLVYJBZJHMRIY-UHFFFAOYSA-N 0.000 description 4
- 230000002381 testicular Effects 0.000 description 4
- 229940124597 therapeutic agent Drugs 0.000 description 4
- 229920001169 thermoplastic Polymers 0.000 description 4
- 229920002725 thermoplastic elastomer Polymers 0.000 description 4
- 239000004416 thermosoftening plastic Substances 0.000 description 4
- 238000011282 treatment Methods 0.000 description 4
- 229940126307 triamcinolone acetate Drugs 0.000 description 4
- YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 description 4
- IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 description 4
- 229960001082 trimethoprim Drugs 0.000 description 4
- 229960001572 vancomycin hydrochloride Drugs 0.000 description 4
- LCTORFDMHNKUSG-XTTLPDOESA-N vancomycin monohydrochloride Chemical compound Cl.O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 LCTORFDMHNKUSG-XTTLPDOESA-N 0.000 description 4
- 230000001720 vestibular Effects 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 229960004276 zoledronic acid Drugs 0.000 description 4
- BXTJCSYMGFJEID-XMTADJHZSA-N (2s)-2-[[(2r,3r)-3-[(2s)-1-[(3r,4s,5s)-4-[[(2s)-2-[[(2s)-2-[6-[3-[(2r)-2-amino-2-carboxyethyl]sulfanyl-2,5-dioxopyrrolidin-1-yl]hexanoyl-methylamino]-3-methylbutanoyl]amino]-3-methylbutanoyl]-methylamino]-3-methoxy-5-methylheptanoyl]pyrrolidin-2-yl]-3-met Chemical compound C([C@H](NC(=O)[C@H](C)[C@@H](OC)[C@@H]1CCCN1C(=O)C[C@H]([C@H]([C@@H](C)CC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)CCCCCN1C(C(SC[C@H](N)C(O)=O)CC1=O)=O)C(C)C)OC)C(O)=O)C1=CC=CC=C1 BXTJCSYMGFJEID-XMTADJHZSA-N 0.000 description 3
- HMLGSIZOMSVISS-ONJSNURVSA-N (7r)-7-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-(2,2-dimethylpropanoyloxymethoxyimino)acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical compound N([C@@H]1C(N2C(=C(C=C)CSC21)C(O)=O)=O)C(=O)\C(=N/OCOC(=O)C(C)(C)C)C1=CSC(N)=N1 HMLGSIZOMSVISS-ONJSNURVSA-N 0.000 description 3
- GMVPRGQOIOIIMI-UHFFFAOYSA-N (8R,11R,12R,13E,15S)-11,15-Dihydroxy-9-oxo-13-prostenoic acid Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CCCCCCC(O)=O GMVPRGQOIOIIMI-UHFFFAOYSA-N 0.000 description 3
- 229930182837 (R)-adrenaline Natural products 0.000 description 3
- BQCIDUSAKPWEOX-UHFFFAOYSA-N 1,1-Difluoroethene Chemical compound FC(F)=C BQCIDUSAKPWEOX-UHFFFAOYSA-N 0.000 description 3
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 3
- ZXCIEWBDUAPBJF-MUUNZHRXSA-N 2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCCOC[C@@H](OC(C)=O)COP([O-])(=O)OCC[N+](C)(C)C ZXCIEWBDUAPBJF-MUUNZHRXSA-N 0.000 description 3
- VOMKSBFLAZZBOW-UHFFFAOYSA-N 3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-2-methyl-4-oxo-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-9-yl hexadecanoate Chemical compound FC1=CC=C2C(C3CCN(CC3)CCC3=C(C)N=C4N(C3=O)CCCC4OC(=O)CCCCCCCCCCCCCCC)=NOC2=C1 VOMKSBFLAZZBOW-UHFFFAOYSA-N 0.000 description 3
- ZHSKUOZOLHMKEA-UHFFFAOYSA-N 4-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoic acid;hydron;chloride Chemical compound Cl.ClCCN(CCCl)C1=CC=C2N(C)C(CCCC(O)=O)=NC2=C1 ZHSKUOZOLHMKEA-UHFFFAOYSA-N 0.000 description 3
- XAUDJQYHKZQPEU-KVQBGUIXSA-N 5-aza-2'-deoxycytidine Chemical compound O=C1N=C(N)N=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 XAUDJQYHKZQPEU-KVQBGUIXSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- KWTQSFXGGICVPE-WCCKRBBISA-N Arginine hydrochloride Chemical compound Cl.OC(=O)[C@@H](N)CCCN=C(N)N KWTQSFXGGICVPE-WCCKRBBISA-N 0.000 description 3
- 102100032306 Aurora kinase B Human genes 0.000 description 3
- 108010006654 Bleomycin Proteins 0.000 description 3
- 108030001720 Bontoxilysin Proteins 0.000 description 3
- 102100029895 Bromodomain-containing protein 4 Human genes 0.000 description 3
- 101710126815 Bromodomain-containing protein 4 Proteins 0.000 description 3
- LIRCDOVJWUGTMW-ZWNOBZJWSA-N Chloramphenicol succinate Chemical compound OC(=O)CCC(=O)OC[C@@H](NC(=O)C(Cl)Cl)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 LIRCDOVJWUGTMW-ZWNOBZJWSA-N 0.000 description 3
- 108010078777 Colistin Proteins 0.000 description 3
- 229920000089 Cyclic olefin copolymer Polymers 0.000 description 3
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 3
- 108010000437 Deamino Arginine Vasopressin Proteins 0.000 description 3
- 102100038595 Estrogen receptor Human genes 0.000 description 3
- 108010008165 Etanercept Proteins 0.000 description 3
- 102000008175 FSH Receptors Human genes 0.000 description 3
- 108010060374 FSH Receptors Proteins 0.000 description 3
- 241000714174 Feline sarcoma virus Species 0.000 description 3
- 102000000393 Ghrelin Receptors Human genes 0.000 description 3
- 108010016122 Ghrelin Receptors Proteins 0.000 description 3
- 101000610970 Homo sapiens Mitochondrial thiamine pyrophosphate carrier Proteins 0.000 description 3
- 108010057186 Insulin Glargine Proteins 0.000 description 3
- COCFEDIXXNGUNL-RFKWWTKHSA-N Insulin glargine Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(=O)NCC(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 COCFEDIXXNGUNL-RFKWWTKHSA-N 0.000 description 3
- JUZNIMUFDBIJCM-ANEDZVCMSA-N Invanz Chemical compound O=C([C@H]1NC[C@H](C1)SC=1[C@H](C)[C@@H]2[C@H](C(N2C=1C(O)=O)=O)[C@H](O)C)NC1=CC=CC(C(O)=O)=C1 JUZNIMUFDBIJCM-ANEDZVCMSA-N 0.000 description 3
- AMDBBAQNWSUWGN-UHFFFAOYSA-N Ioversol Chemical compound OCCN(C(=O)CO)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I AMDBBAQNWSUWGN-UHFFFAOYSA-N 0.000 description 3
- 239000004472 Lysine Substances 0.000 description 3
- 108091022875 Microtubule Proteins 0.000 description 3
- 102000029749 Microtubule Human genes 0.000 description 3
- 102100040420 Mitochondrial thiamine pyrophosphate carrier Human genes 0.000 description 3
- CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 description 3
- 102100021867 Natural resistance-associated macrophage protein 2 Human genes 0.000 description 3
- 108010003541 Platelet Activating Factor Proteins 0.000 description 3
- 102000000033 Purinergic Receptors Human genes 0.000 description 3
- 108010080192 Purinergic Receptors Proteins 0.000 description 3
- 206010039491 Sarcoma Diseases 0.000 description 3
- 102100032008 Solute carrier family 40 member 1 Human genes 0.000 description 3
- 229940100514 Syk tyrosine kinase inhibitor Drugs 0.000 description 3
- 102100040296 TATA-box-binding protein Human genes 0.000 description 3
- 239000004699 Ultra-high molecular weight polyethylene Substances 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 229940060202 adenoscan Drugs 0.000 description 3
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 3
- 229960000711 alprostadil Drugs 0.000 description 3
- 229960003234 amiodarone hydrochloride Drugs 0.000 description 3
- 239000003708 ampul Substances 0.000 description 3
- 229960004238 anakinra Drugs 0.000 description 3
- WZPBZJONDBGPKJ-VEHQQRBSSA-N aztreonam Chemical compound O=C1N(S([O-])(=O)=O)[C@@H](C)[C@@H]1NC(=O)C(=N/OC(C)(C)C(O)=O)\C1=CSC([NH3+])=N1 WZPBZJONDBGPKJ-VEHQQRBSSA-N 0.000 description 3
- 229940035070 baclofen injection Drugs 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- CPFJLLXFNPCTDW-BWSPSPBFSA-N benzatropine mesylate Chemical compound CS([O-])(=O)=O.O([C@H]1C[C@H]2CC[C@@H](C1)[NH+]2C)C(C=1C=CC=CC=1)C1=CC=CC=C1 CPFJLLXFNPCTDW-BWSPSPBFSA-N 0.000 description 3
- 239000003124 biologic agent Substances 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000000988 bone and bone Anatomy 0.000 description 3
- 229940053031 botulinum toxin Drugs 0.000 description 3
- BMQGVNUXMIRLCK-OAGWZNDDSA-N cabazitaxel Chemical compound O([C@H]1[C@@H]2[C@]3(OC(C)=O)CO[C@@H]3C[C@@H]([C@]2(C(=O)[C@H](OC)C2=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=3C=CC=CC=3)C[C@]1(O)C2(C)C)C)OC)C(=O)C1=CC=CC=C1 BMQGVNUXMIRLCK-OAGWZNDDSA-N 0.000 description 3
- 229930195731 calicheamicin Natural products 0.000 description 3
- HXCHCVDVKSCDHU-LULTVBGHSA-N calicheamicin Chemical compound C1[C@H](OC)[C@@H](NCC)CO[C@H]1O[C@H]1[C@H](O[C@@H]2C\3=C(NC(=O)OC)C(=O)C[C@](C/3=C/CSSSC)(O)C#C\C=C/C#C2)O[C@H](C)[C@@H](NO[C@@H]2O[C@H](C)[C@@H](SC(=O)C=3C(=C(OC)C(O[C@H]4[C@@H]([C@H](OC)[C@@H](O)[C@H](C)O4)O)=C(I)C=3C)OC)[C@@H](O)C2)[C@@H]1O HXCHCVDVKSCDHU-LULTVBGHSA-N 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 229960004407 chorionic gonadotrophin Drugs 0.000 description 3
- DHSUYTOATWAVLW-WFVMDLQDSA-N cilastatin Chemical compound CC1(C)C[C@@H]1C(=O)N\C(=C/CCCCSC[C@H](N)C(O)=O)C(O)=O DHSUYTOATWAVLW-WFVMDLQDSA-N 0.000 description 3
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 description 3
- 230000006835 compression Effects 0.000 description 3
- 238000007906 compression Methods 0.000 description 3
- 108700033697 corticorelin ovine Proteins 0.000 description 3
- 238000000151 deposition Methods 0.000 description 3
- 239000008355 dextrose injection Substances 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- SLYTULCOCGSBBJ-UHFFFAOYSA-I disodium;2-[[2-[bis(carboxylatomethyl)amino]-3-(4-ethoxyphenyl)propyl]-[2-[bis(carboxylatomethyl)amino]ethyl]amino]acetate;gadolinium(3+) Chemical compound [Na+].[Na+].[Gd+3].CCOC1=CC=C(CC(CN(CCN(CC([O-])=O)CC([O-])=O)CC([O-])=O)N(CC([O-])=O)CC([O-])=O)C=C1 SLYTULCOCGSBBJ-UHFFFAOYSA-I 0.000 description 3
- HKXBNHCUPKIYDM-CGMHZMFXSA-N doxercalciferol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C HKXBNHCUPKIYDM-CGMHZMFXSA-N 0.000 description 3
- 229960005153 enoxaparin sodium Drugs 0.000 description 3
- 229960005139 epinephrine Drugs 0.000 description 3
- 229940011871 estrogen Drugs 0.000 description 3
- 239000000262 estrogen Substances 0.000 description 3
- 230000003325 follicular Effects 0.000 description 3
- 229940044880 fosaprepitant dimeglumine Drugs 0.000 description 3
- 229960003023 gadofosveset trisodium Drugs 0.000 description 3
- 210000004602 germ cell Anatomy 0.000 description 3
- 210000002768 hair cell Anatomy 0.000 description 3
- 229960005472 ibutilide fumarate Drugs 0.000 description 3
- 229960001176 idarubicin hydrochloride Drugs 0.000 description 3
- 210000000987 immune system Anatomy 0.000 description 3
- 239000003112 inhibitor Substances 0.000 description 3
- 238000007913 intrathecal administration Methods 0.000 description 3
- 238000010253 intravenous injection Methods 0.000 description 3
- 210000003734 kidney Anatomy 0.000 description 3
- RGLRXNKKBLIBQS-XNHQSDQCSA-N leuprolide acetate Chemical compound CC(O)=O.CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)CC1=CC=C(O)C=C1 RGLRXNKKBLIBQS-XNHQSDQCSA-N 0.000 description 3
- 102000004311 liver X receptors Human genes 0.000 description 3
- 108090000865 liver X receptors Proteins 0.000 description 3
- 230000001050 lubricating effect Effects 0.000 description 3
- 229940076783 lucentis Drugs 0.000 description 3
- 238000003754 machining Methods 0.000 description 3
- 235000010355 mannitol Nutrition 0.000 description 3
- PLBHSZGDDKCEHR-LFYFAGGJSA-N methylprednisolone acetate Chemical compound C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@](O)(C(=O)COC(C)=O)CC[C@H]21 PLBHSZGDDKCEHR-LFYFAGGJSA-N 0.000 description 3
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical group CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 3
- 210000004688 microtubule Anatomy 0.000 description 3
- RAHBGWKEPAQNFF-UHFFFAOYSA-N motesanib Chemical compound C=1C=C2C(C)(C)CNC2=CC=1NC(=O)C1=CC=CN=C1NCC1=CC=NC=C1 RAHBGWKEPAQNFF-UHFFFAOYSA-N 0.000 description 3
- 230000035772 mutation Effects 0.000 description 3
- CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 description 3
- QEEJLLNYQOBRRM-KSHGRFHLSA-N ovine crf Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H]1N(CCC1)C(=O)[C@H]1N(CCC1)C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CO)[C@@H](C)CC)[C@@H](C)O)C(C)C)[C@@H](C)O)C1=CN=CN1 QEEJLLNYQOBRRM-KSHGRFHLSA-N 0.000 description 3
- 229960000635 paliperidone palmitate Drugs 0.000 description 3
- 229960002621 pembrolizumab Drugs 0.000 description 3
- 229960002087 pertuzumab Drugs 0.000 description 3
- 229960002516 physostigmine salicylate Drugs 0.000 description 3
- HZOTZTANVBDFOF-PBCQUBLHSA-N physostigmine salicylate Chemical compound OC(=O)C1=CC=CC=C1O.C12=CC(OC(=O)NC)=CC=C2N(C)[C@@H]2[C@@]1(C)CCN2C HZOTZTANVBDFOF-PBCQUBLHSA-N 0.000 description 3
- XDJYMJULXQKGMM-UHFFFAOYSA-N polymyxin E1 Natural products CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O XDJYMJULXQKGMM-UHFFFAOYSA-N 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- 229940092597 prolia Drugs 0.000 description 3
- 229960003471 retinol Drugs 0.000 description 3
- 235000020944 retinol Nutrition 0.000 description 3
- 239000011607 retinol Substances 0.000 description 3
- 210000004918 root sheath Anatomy 0.000 description 3
- ZNSIZMQNQCNRBW-UHFFFAOYSA-N sevelamer Chemical compound NCC=C.ClCC1CO1 ZNSIZMQNQCNRBW-UHFFFAOYSA-N 0.000 description 3
- PTJRZVJXXNYNLN-UHFFFAOYSA-M sodium;2h-pyrazolo[3,4-d]pyrimidin-1-id-4-one Chemical compound [Na+].[O-]C1=NC=NC2=C1C=NN2 PTJRZVJXXNYNLN-UHFFFAOYSA-M 0.000 description 3
- LXLBEOAZMZAZND-UHFFFAOYSA-M sodium;hydroxy-[1-hydroxy-3-[methyl(pentyl)amino]-1-phosphonopropyl]phosphinate Chemical compound [Na+].CCCCCN(C)CCC(O)(P(O)(O)=O)P(O)([O-])=O LXLBEOAZMZAZND-UHFFFAOYSA-M 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 229960004739 sufentanil Drugs 0.000 description 3
- GGCSSNBKKAUURC-UHFFFAOYSA-N sufentanil Chemical compound C1CN(CCC=2SC=CC=2)CCC1(COC)N(C(=O)CC)C1=CC=CC=C1 GGCSSNBKKAUURC-UHFFFAOYSA-N 0.000 description 3
- 229960003604 testosterone Drugs 0.000 description 3
- CIJQTPFWFXOSEO-NDMITSJXSA-J tetrasodium;(2r,3r,4s)-2-[(2r,3s,4r,5r,6s)-5-acetamido-6-[(1r,2r,3r,4r)-4-[(2r,3s,4r,5r,6r)-5-acetamido-6-[(4r,5r,6r)-2-carboxylato-4,5-dihydroxy-6-[[(1r,3r,4r,5r)-3-hydroxy-4-(sulfonatoamino)-6,8-dioxabicyclo[3.2.1]octan-2-yl]oxy]oxan-3-yl]oxy-2-(hydroxy Chemical compound [Na+].[Na+].[Na+].[Na+].O([C@@H]1[C@@H](COS(O)(=O)=O)O[C@@H]([C@@H]([C@H]1O)NC(C)=O)O[C@@H]1C(C[C@H]([C@@H]([C@H]1O)O)O[C@@H]1[C@@H](CO)O[C@H](OC2C(O[C@@H](OC3[C@@H]([C@@H](NS([O-])(=O)=O)[C@@H]4OC[C@H]3O4)O)[C@H](O)[C@H]2O)C([O-])=O)[C@H](NC(C)=O)[C@H]1C)C([O-])=O)[C@@H]1OC(C([O-])=O)=C[C@H](O)[C@H]1O CIJQTPFWFXOSEO-NDMITSJXSA-J 0.000 description 3
- 229940114462 tobramycin injection Drugs 0.000 description 3
- 229960000575 trastuzumab Drugs 0.000 description 3
- 229960001612 trastuzumab emtansine Drugs 0.000 description 3
- VXKHXGOKWPXYNA-PGBVPBMZSA-N triptorelin Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 VXKHXGOKWPXYNA-PGBVPBMZSA-N 0.000 description 3
- DFHAXXVZCFXGOQ-UHFFFAOYSA-K trisodium phosphonoformate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)P([O-])([O-])=O DFHAXXVZCFXGOQ-UHFFFAOYSA-K 0.000 description 3
- 229920000785 ultra high molecular weight polyethylene Polymers 0.000 description 3
- 239000011800 void material Substances 0.000 description 3
- BMKDZUISNHGIBY-ZETCQYMHSA-N (+)-dexrazoxane Chemical compound C([C@H](C)N1CC(=O)NC(=O)C1)N1CC(=O)NC(=O)C1 BMKDZUISNHGIBY-ZETCQYMHSA-N 0.000 description 2
- OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 description 2
- NMWKYTGJWUAZPZ-WWHBDHEGSA-N (4S)-4-[[(4R,7S,10S,16S,19S,25S,28S,31R)-31-[[(2S)-2-[[(1R,6R,9S,12S,18S,21S,24S,27S,30S,33S,36S,39S,42R,47R,53S,56S,59S,62S,65S,68S,71S,76S,79S,85S)-47-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-3-phenylpropanoyl]amino]-4-oxobutanoyl]amino]-3-carboxypropanoyl]amino]-18-(4-aminobutyl)-27,68-bis(3-amino-3-oxopropyl)-36,71,76-tribenzyl-39-(3-carbamimidamidopropyl)-24-(2-carboxyethyl)-21,56-bis(carboxymethyl)-65,85-bis[(1R)-1-hydroxyethyl]-59-(hydroxymethyl)-62,79-bis(1H-imidazol-4-ylmethyl)-9-methyl-33-(2-methylpropyl)-8,11,17,20,23,26,29,32,35,38,41,48,54,57,60,63,66,69,72,74,77,80,83,86-tetracosaoxo-30-propan-2-yl-3,4,44,45-tetrathia-7,10,16,19,22,25,28,31,34,37,40,49,55,58,61,64,67,70,73,75,78,81,84,87-tetracosazatetracyclo[40.31.14.012,16.049,53]heptaoctacontane-6-carbonyl]amino]-3-methylbutanoyl]amino]-7-(3-carbamimidamidopropyl)-25-(hydroxymethyl)-19-[(4-hydroxyphenyl)methyl]-28-(1H-imidazol-4-ylmethyl)-10-methyl-6,9,12,15,18,21,24,27,30-nonaoxo-16-propan-2-yl-1,2-dithia-5,8,11,14,17,20,23,26,29-nonazacyclodotriacontane-4-carbonyl]amino]-5-[[(2S)-1-[[(2S)-1-[[(2S)-3-carboxy-1-[[(2S)-1-[[(2S)-1-[[(1S)-1-carboxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid Chemical compound CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc4c[nH]cn4)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]4CCCN4C(=O)[C@H](CSSC[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](Cc4c[nH]cn4)NC(=O)[C@H](Cc4ccccc4)NC3=O)[C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N3CCC[C@H]3C(=O)N[C@@H](C)C(=O)N2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)C(C)C)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1)C(=O)N[C@@H](C)C(O)=O NMWKYTGJWUAZPZ-WWHBDHEGSA-N 0.000 description 2
- BZPCMSSQHRAJCC-UHFFFAOYSA-N 1,2,3,3,4,4,5,5,5-nonafluoro-1-(1,2,3,3,4,4,5,5,5-nonafluoropent-1-enoxy)pent-1-ene Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)=C(F)OC(F)=C(F)C(F)(F)C(F)(F)C(F)(F)F BZPCMSSQHRAJCC-UHFFFAOYSA-N 0.000 description 2
- ZYRBXTNFHYZHSK-UHFFFAOYSA-N 1-(2,4,6-Trimethoxyphenyl)-1,3-butanedione Chemical compound COC1=CC(OC)=C(C(=O)CC(C)=O)C(OC)=C1 ZYRBXTNFHYZHSK-UHFFFAOYSA-N 0.000 description 2
- UOTMYNBWXDUBNX-UHFFFAOYSA-N 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxyisoquinolin-2-ium;chloride Chemical compound Cl.C1=C(OC)C(OC)=CC=C1CC1=NC=CC2=CC(OC)=C(OC)C=C12 UOTMYNBWXDUBNX-UHFFFAOYSA-N 0.000 description 2
- OZOMQRBLCMDCEG-CHHVJCJISA-N 1-[(z)-[5-(4-nitrophenyl)furan-2-yl]methylideneamino]imidazolidine-2,4-dione Chemical compound C1=CC([N+](=O)[O-])=CC=C1C(O1)=CC=C1\C=N/N1C(=O)NC(=O)C1 OZOMQRBLCMDCEG-CHHVJCJISA-N 0.000 description 2
- MFWNKCLOYSRHCJ-AGUYFDCRSA-N 1-methyl-N-[(1S,5R)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]-3-indazolecarboxamide Chemical compound C1=CC=C2C(C(=O)NC3C[C@H]4CCC[C@@H](C3)N4C)=NN(C)C2=C1 MFWNKCLOYSRHCJ-AGUYFDCRSA-N 0.000 description 2
- KJCVRFUGPWSIIH-UHFFFAOYSA-N 1-naphthol Chemical compound C1=CC=C2C(O)=CC=CC2=C1 KJCVRFUGPWSIIH-UHFFFAOYSA-N 0.000 description 2
- NCYCYZXNIZJOKI-IOUUIBBYSA-N 11-cis-retinal Chemical compound O=C/C=C(\C)/C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-IOUUIBBYSA-N 0.000 description 2
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 2
- VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 description 2
- ZCXUVYAZINUVJD-AHXZWLDOSA-N 2-deoxy-2-((18)F)fluoro-alpha-D-glucose Chemical compound OC[C@H]1O[C@H](O)[C@H]([18F])[C@@H](O)[C@@H]1O ZCXUVYAZINUVJD-AHXZWLDOSA-N 0.000 description 2
- WUIABRMSWOKTOF-OYALTWQYSA-N 3-[[2-[2-[2-[[(2s,3r)-2-[[(2s,3s,4r)-4-[[(2s,3r)-2-[[6-amino-2-[(1s)-3-amino-1-[[(2s)-2,3-diamino-3-oxopropyl]amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[(2r,3s,4s,5s,6s)-3-[(2r,3s,4s,5r,6r)-4-carbamoyloxy-3,5-dihydroxy-6-(hydroxymethyl)ox Chemical compound OS([O-])(=O)=O.N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1NC=NC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C WUIABRMSWOKTOF-OYALTWQYSA-N 0.000 description 2
- MEAPRSDUXBHXGD-UHFFFAOYSA-N 3-chloro-n-(4-propan-2-ylphenyl)propanamide Chemical compound CC(C)C1=CC=C(NC(=O)CCCl)C=C1 MEAPRSDUXBHXGD-UHFFFAOYSA-N 0.000 description 2
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 2
- 102000007469 Actins Human genes 0.000 description 2
- 108010085238 Actins Proteins 0.000 description 2
- 229940124963 Afluria Drugs 0.000 description 2
- 102100032187 Androgen receptor Human genes 0.000 description 2
- 102100022014 Angiopoietin-1 receptor Human genes 0.000 description 2
- 108010052412 Apelin Proteins 0.000 description 2
- 102000018746 Apelin Human genes 0.000 description 2
- 108091023037 Aptamer Proteins 0.000 description 2
- 102000004000 Aurora Kinase A Human genes 0.000 description 2
- 108090000461 Aurora Kinase A Proteins 0.000 description 2
- 108090000749 Aurora kinase B Proteins 0.000 description 2
- 102100026630 Aurora kinase C Human genes 0.000 description 2
- 108090000805 Aurora kinase C Proteins 0.000 description 2
- 241000271566 Aves Species 0.000 description 2
- 102100024507 BMP-2-inducible protein kinase Human genes 0.000 description 2
- 108010039209 Blood Coagulation Factors Proteins 0.000 description 2
- 102000015081 Blood Coagulation Factors Human genes 0.000 description 2
- 206010006187 Breast cancer Diseases 0.000 description 2
- 208000026310 Breast neoplasm Diseases 0.000 description 2
- DTPWZYSUQQHRKD-VIUAGAKSSA-N CC(O)=O.CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O Chemical compound CC(O)=O.CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O DTPWZYSUQQHRKD-VIUAGAKSSA-N 0.000 description 2
- WEDIKSVWBUKTRA-WTKGVUNUSA-N CC[C@H](C)[C@H](NC(=O)CN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc3c[nH]cn3)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccccc3)C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](Cc3c[nH]cn3)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)NC1=O)[C@@H](C)O)[C@@H](C)CC Chemical compound CC[C@H](C)[C@H](NC(=O)CN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc3c[nH]cn3)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccccc3)C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](Cc3c[nH]cn3)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)NC1=O)[C@@H](C)O)[C@@H](C)CC WEDIKSVWBUKTRA-WTKGVUNUSA-N 0.000 description 2
- 108010040163 CREB-Binding Protein Proteins 0.000 description 2
- 102100021975 CREB-binding protein Human genes 0.000 description 2
- 108010069682 CSK Tyrosine-Protein Kinase Proteins 0.000 description 2
- 101100098709 Caenorhabditis elegans taf-1 gene Proteins 0.000 description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 2
- 102100034279 Calcium-binding mitochondrial carrier protein Aralar2 Human genes 0.000 description 2
- 102000014914 Carrier Proteins Human genes 0.000 description 2
- 108010077544 Chromatin Proteins 0.000 description 2
- 235000001258 Cinchona calisaya Nutrition 0.000 description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 2
- GJSURZIOUXUGAL-UHFFFAOYSA-N Clonidine Chemical compound ClC1=CC=CC(Cl)=C1NC1=NCCN1 GJSURZIOUXUGAL-UHFFFAOYSA-N 0.000 description 2
- 239000004713 Cyclic olefin copolymer Substances 0.000 description 2
- 102000004127 Cytokines Human genes 0.000 description 2
- 108090000695 Cytokines Proteins 0.000 description 2
- 102100027907 Cytoplasmic tyrosine-protein kinase BMX Human genes 0.000 description 2
- 101100481408 Danio rerio tie2 gene Proteins 0.000 description 2
- 108010013198 Daptomycin Proteins 0.000 description 2
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 2
- 101100108136 Drosophila melanogaster Adck1 gene Proteins 0.000 description 2
- 102100036109 Dual specificity protein kinase TTK Human genes 0.000 description 2
- NVTRPRFAWJGJAJ-UHFFFAOYSA-L EDTA monocalcium salt Chemical compound [Ca+2].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O NVTRPRFAWJGJAJ-UHFFFAOYSA-L 0.000 description 2
- 229940126626 Ektomab Drugs 0.000 description 2
- 108010061435 Enalapril Proteins 0.000 description 2
- 101710199605 Endoribonuclease Proteins 0.000 description 2
- 108010032976 Enfuvirtide Proteins 0.000 description 2
- UOACKFBJUYNSLK-XRKIENNPSA-N Estradiol Cypionate Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H](C4=CC=C(O)C=C4CC3)CC[C@@]21C)C(=O)CCC1CCCC1 UOACKFBJUYNSLK-XRKIENNPSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- ITIONVBQFUNVJV-UHFFFAOYSA-N Etomidoline Chemical compound C12=CC=CC=C2C(=O)N(CC)C1NC(C=C1)=CC=C1OCCN1CCCCC1 ITIONVBQFUNVJV-UHFFFAOYSA-N 0.000 description 2
- 108010022894 Euchromatin Proteins 0.000 description 2
- 102100031560 Excitatory amino acid transporter 3 Human genes 0.000 description 2
- 108010011459 Exenatide Proteins 0.000 description 2
- HTQBXNHDCUEHJF-XWLPCZSASA-N Exenatide Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 HTQBXNHDCUEHJF-XWLPCZSASA-N 0.000 description 2
- 229940126611 FBTA05 Drugs 0.000 description 2
- 102000018233 Fibroblast Growth Factor Human genes 0.000 description 2
- 108050007372 Fibroblast Growth Factor Proteins 0.000 description 2
- 102100037362 Fibronectin Human genes 0.000 description 2
- 229940124946 Flucelvax Drugs 0.000 description 2
- 229940124894 Fluzone Drugs 0.000 description 2
- 241000027294 Fusi Species 0.000 description 2
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 description 2
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 description 2
- 229940124897 Gardasil Drugs 0.000 description 2
- 101800001586 Ghrelin Proteins 0.000 description 2
- 102400000442 Ghrelin-28 Human genes 0.000 description 2
- 102000034615 Glial cell line-derived neurotrophic factor Human genes 0.000 description 2
- 108091010837 Glial cell line-derived neurotrophic factor Proteins 0.000 description 2
- 108090000079 Glucocorticoid Receptors Proteins 0.000 description 2
- 102100033417 Glucocorticoid receptor Human genes 0.000 description 2
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 description 2
- 102100039619 Granulocyte colony-stimulating factor Human genes 0.000 description 2
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 2
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 description 2
- 101710198286 Growth hormone-releasing hormone receptor Proteins 0.000 description 2
- 102100033365 Growth hormone-releasing hormone receptor Human genes 0.000 description 2
- 229940124914 Havrix Drugs 0.000 description 2
- 102000003745 Hepatocyte Growth Factor Human genes 0.000 description 2
- 108090000100 Hepatocyte Growth Factor Proteins 0.000 description 2
- 102100022623 Hepatocyte growth factor receptor Human genes 0.000 description 2
- 108090001101 Hepsin Proteins 0.000 description 2
- 102000004989 Hepsin Human genes 0.000 description 2
- 102100022846 Histone acetyltransferase KAT2B Human genes 0.000 description 2
- 102100038885 Histone acetyltransferase p300 Human genes 0.000 description 2
- 101000762370 Homo sapiens BMP-2-inducible protein kinase Proteins 0.000 description 2
- 101000935548 Homo sapiens Cytoplasmic tyrosine-protein kinase BMX Proteins 0.000 description 2
- 101000659223 Homo sapiens Dual specificity protein kinase TTK Proteins 0.000 description 2
- 101000866302 Homo sapiens Excitatory amino acid transporter 3 Proteins 0.000 description 2
- 101001027128 Homo sapiens Fibronectin Proteins 0.000 description 2
- 101000882390 Homo sapiens Histone acetyltransferase p300 Proteins 0.000 description 2
- 101001018026 Homo sapiens Lysosomal alpha-glucosidase Proteins 0.000 description 2
- 101000934489 Homo sapiens Nucleosome-remodeling factor subunit BPTF Proteins 0.000 description 2
- 101001123492 Homo sapiens Prolactin-releasing peptide receptor Proteins 0.000 description 2
- 101000878540 Homo sapiens Protein-tyrosine kinase 2-beta Proteins 0.000 description 2
- 101000617778 Homo sapiens SNF-related serine/threonine-protein kinase Proteins 0.000 description 2
- 101000693598 Homo sapiens Serine/threonine-protein kinase SBK1 Proteins 0.000 description 2
- 101000654491 Homo sapiens Serine/threonine-protein kinase SIK3 Proteins 0.000 description 2
- 101000595531 Homo sapiens Serine/threonine-protein kinase pim-1 Proteins 0.000 description 2
- 101000740162 Homo sapiens Sodium- and chloride-dependent transporter XTRP3 Proteins 0.000 description 2
- 101000869719 Homo sapiens Sodium-dependent phosphate transporter 2 Proteins 0.000 description 2
- 101000821972 Homo sapiens Solute carrier family 4 member 11 Proteins 0.000 description 2
- 101000637813 Homo sapiens Solute carrier family 40 member 1 Proteins 0.000 description 2
- 101000662997 Homo sapiens TRAF2 and NCK-interacting protein kinase Proteins 0.000 description 2
- 101001047681 Homo sapiens Tyrosine-protein kinase Lck Proteins 0.000 description 2
- 108060006678 I-kappa-B kinase Proteins 0.000 description 2
- 102000001284 I-kappa-B kinase Human genes 0.000 description 2
- MPBVHIBUJCELCL-UHFFFAOYSA-N Ibandronate Chemical compound CCCCCN(C)CCC(O)(P(O)(O)=O)P(O)(O)=O MPBVHIBUJCELCL-UHFFFAOYSA-N 0.000 description 2
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 2
- 108091006081 Inositol-requiring enzyme-1 Proteins 0.000 description 2
- 102000004877 Insulin Human genes 0.000 description 2
- 108090001061 Insulin Proteins 0.000 description 2
- 108010073961 Insulin Aspart Proteins 0.000 description 2
- 102100039137 Insulin receptor-related protein Human genes 0.000 description 2
- 102100040018 Interferon alpha-2 Human genes 0.000 description 2
- 108010079944 Interferon-alpha2b Proteins 0.000 description 2
- 102100034170 Interferon-induced, double-stranded RNA-activated protein kinase Human genes 0.000 description 2
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 description 2
- 102000016267 Leptin Human genes 0.000 description 2
- 108010092277 Leptin Proteins 0.000 description 2
- 102100033374 Leukotriene B4 receptor 1 Human genes 0.000 description 2
- 108010000817 Leuprolide Proteins 0.000 description 2
- YSDQQAXHVYUZIW-QCIJIYAXSA-N Liraglutide Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCC)C(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=C(O)C=C1 YSDQQAXHVYUZIW-QCIJIYAXSA-N 0.000 description 2
- 108010019598 Liraglutide Proteins 0.000 description 2
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
- 108090000301 Membrane transport proteins Proteins 0.000 description 2
- 108010057021 Menotropins Proteins 0.000 description 2
- 102100021316 Mineralocorticoid receptor Human genes 0.000 description 2
- 241000714177 Murine leukemia virus Species 0.000 description 2
- 101100481410 Mus musculus Tek gene Proteins 0.000 description 2
- 102100035044 Myosin light chain kinase, smooth muscle Human genes 0.000 description 2
- 108010074596 Myosin-Light-Chain Kinase Proteins 0.000 description 2
- 101710167853 N-methyltransferase Proteins 0.000 description 2
- 102000007399 Nuclear hormone receptor Human genes 0.000 description 2
- 108020005497 Nuclear hormone receptor Proteins 0.000 description 2
- 102100025062 Nucleosome-remodeling factor subunit BPTF Human genes 0.000 description 2
- 108010072194 Ovidrel Proteins 0.000 description 2
- 102100028139 Oxytocin receptor Human genes 0.000 description 2
- 108090000876 Oxytocin receptors Proteins 0.000 description 2
- 108010016731 PPAR gamma Proteins 0.000 description 2
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 2
- 108091005804 Peptidases Proteins 0.000 description 2
- 102000035195 Peptidases Human genes 0.000 description 2
- 102000005877 Peptide Initiation Factors Human genes 0.000 description 2
- 108010044843 Peptide Initiation Factors Proteins 0.000 description 2
- 102100038831 Peroxisome proliferator-activated receptor alpha Human genes 0.000 description 2
- 102100038824 Peroxisome proliferator-activated receptor delta Human genes 0.000 description 2
- 102100038825 Peroxisome proliferator-activated receptor gamma Human genes 0.000 description 2
- UQVKZNNCIHJZLS-UHFFFAOYSA-N PhIP Chemical compound C1=C2N(C)C(N)=NC2=NC=C1C1=CC=CC=C1 UQVKZNNCIHJZLS-UHFFFAOYSA-N 0.000 description 2
- 108010038512 Platelet-Derived Growth Factor Proteins 0.000 description 2
- 102000010780 Platelet-Derived Growth Factor Human genes 0.000 description 2
- 239000004696 Poly ether ether ketone Substances 0.000 description 2
- 108010002519 Prolactin Receptors Proteins 0.000 description 2
- 102100029000 Prolactin receptor Human genes 0.000 description 2
- 102100029002 Prolactin-releasing peptide receptor Human genes 0.000 description 2
- 239000004365 Protease Substances 0.000 description 2
- 102100037787 Protein-tyrosine kinase 2-beta Human genes 0.000 description 2
- 102100039810 Protein-tyrosine kinase 6 Human genes 0.000 description 2
- 102000052575 Proto-Oncogene Human genes 0.000 description 2
- 108700020978 Proto-Oncogene Proteins 0.000 description 2
- 108010046934 Proto-Oncogene Proteins c-hck Proteins 0.000 description 2
- 238000012228 RNA interference-mediated gene silencing Methods 0.000 description 2
- 102000003743 Relaxin Human genes 0.000 description 2
- 108090000103 Relaxin Proteins 0.000 description 2
- 102100023606 Retinoic acid receptor alpha Human genes 0.000 description 2
- 102100033909 Retinoic acid receptor beta Human genes 0.000 description 2
- 102100040756 Rhodopsin Human genes 0.000 description 2
- 108090000820 Rhodopsin Proteins 0.000 description 2
- 108091006618 SLC11A2 Proteins 0.000 description 2
- 102100022010 SNF-related serine/threonine-protein kinase Human genes 0.000 description 2
- IRHXGOXEBNJUSN-YOXDLBRISA-N Saquinavir mesylate Chemical compound CS(O)(=O)=O.C([C@@H]([C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)C=1N=C2C=CC=CC2=CC=1)C1=CC=CC=C1 IRHXGOXEBNJUSN-YOXDLBRISA-N 0.000 description 2
- 101710116197 Serine/threonine kinase NLK Proteins 0.000 description 2
- 101710113029 Serine/threonine-protein kinase Proteins 0.000 description 2
- 102100031075 Serine/threonine-protein kinase Chk2 Human genes 0.000 description 2
- 102100034447 Serine/threonine-protein kinase NLK Human genes 0.000 description 2
- 101710175706 Serine/threonine-protein kinase NLK Proteins 0.000 description 2
- 102100025554 Serine/threonine-protein kinase SBK1 Human genes 0.000 description 2
- 102100031445 Serine/threonine-protein kinase SIK3 Human genes 0.000 description 2
- 102100036077 Serine/threonine-protein kinase pim-1 Human genes 0.000 description 2
- 201000003176 Severe Acute Respiratory Syndrome Diseases 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 102100032419 Sodium-dependent phosphate transporter 2 Human genes 0.000 description 2
- 102100021475 Solute carrier family 4 member 11 Human genes 0.000 description 2
- 108050001286 Somatostatin Receptor Proteins 0.000 description 2
- 102000011096 Somatostatin receptor Human genes 0.000 description 2
- 102100036832 Steroid hormone receptor ERR1 Human genes 0.000 description 2
- 101710172711 Structural protein Proteins 0.000 description 2
- OJCZPLDERGDQRJ-UHFFFAOYSA-N Sufentanil citrate Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.C1CN(CCC=2SC=CC=2)CCC1(COC)N(C(=O)CC)C1=CC=CC=C1 OJCZPLDERGDQRJ-UHFFFAOYSA-N 0.000 description 2
- 108010016672 Syk Kinase Proteins 0.000 description 2
- 210000001744 T-lymphocyte Anatomy 0.000 description 2
- 102100037671 TRAF2 and NCK-interacting protein kinase Human genes 0.000 description 2
- 108010039185 Tenecteplase Proteins 0.000 description 2
- 108010049264 Teriparatide Proteins 0.000 description 2
- 102100028702 Thyroid hormone receptor alpha Human genes 0.000 description 2
- 102100033451 Thyroid hormone receptor beta Human genes 0.000 description 2
- 108010083268 Transcription Factor TFIID Proteins 0.000 description 2
- 102000004887 Transforming Growth Factor beta Human genes 0.000 description 2
- 108090001012 Transforming Growth Factor beta Proteins 0.000 description 2
- 102400001320 Transforming growth factor alpha Human genes 0.000 description 2
- 101800004564 Transforming growth factor alpha Proteins 0.000 description 2
- DTQVDTLACAAQTR-UHFFFAOYSA-M Trifluoroacetate Chemical compound [O-]C(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 description 2
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 description 2
- 102100031167 Tyrosine-protein kinase CSK Human genes 0.000 description 2
- 102100040959 Tyrosine-protein kinase FRK Human genes 0.000 description 2
- 101710089880 Tyrosine-protein kinase FRK Proteins 0.000 description 2
- 102100027389 Tyrosine-protein kinase HCK Human genes 0.000 description 2
- 102100024036 Tyrosine-protein kinase Lck Human genes 0.000 description 2
- 102100022356 Tyrosine-protein kinase Mer Human genes 0.000 description 2
- 102100038183 Tyrosine-protein kinase SYK Human genes 0.000 description 2
- 102100039079 Tyrosine-protein kinase TXK Human genes 0.000 description 2
- 102100040177 Tyrosine-protein kinase Tec Human genes 0.000 description 2
- 102100037236 Tyrosine-protein kinase receptor UFO Human genes 0.000 description 2
- 102100025558 Uncharacterized serine/threonine-protein kinase SBK3 Human genes 0.000 description 2
- 101710082921 Uncharacterized serine/threonine-protein kinase SBK3 Proteins 0.000 description 2
- 229940124937 Vaqta Drugs 0.000 description 2
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 description 2
- 102000009519 Vascular Endothelial Growth Factor D Human genes 0.000 description 2
- 108010073919 Vascular Endothelial Growth Factor D Proteins 0.000 description 2
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 2
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 2
- JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 description 2
- 102100032279 Zinc transporter ZIP13 Human genes 0.000 description 2
- VEUACKUBDLVUAC-UHFFFAOYSA-N [Na].[Ca] Chemical compound [Na].[Ca] VEUACKUBDLVUAC-UHFFFAOYSA-N 0.000 description 2
- KSHPUQQHKKJVIO-UHFFFAOYSA-N [Na].[Zn] Chemical compound [Na].[Zn] KSHPUQQHKKJVIO-UHFFFAOYSA-N 0.000 description 2
- 108010079650 abobotulinumtoxinA Proteins 0.000 description 2
- 229940022720 acetadote Drugs 0.000 description 2
- 229960004150 aciclovir Drugs 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 229940102614 adacel Drugs 0.000 description 2
- 210000001789 adipocyte Anatomy 0.000 description 2
- 210000001053 ameloblast Anatomy 0.000 description 2
- 229950006061 anatumomab mafenatox Drugs 0.000 description 2
- 108010080146 androgen receptors Proteins 0.000 description 2
- 229950006588 anetumab ravtansine Drugs 0.000 description 2
- 239000005557 antagonist Substances 0.000 description 2
- 230000000692 anti-sense effect Effects 0.000 description 2
- BWVPHIKGXQBZPV-QKFDDRBGSA-N apelin Chemical compound NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N1[C@H](C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=2NC=NC=2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=2NC=NC=2)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CCSC)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(O)=O)CCC1 BWVPHIKGXQBZPV-QKFDDRBGSA-N 0.000 description 2
- RCHHVVGSTHAVPF-ZPHPLDECSA-N apidra Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3N=CNC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CNC=N1 RCHHVVGSTHAVPF-ZPHPLDECSA-N 0.000 description 2
- 229960001164 apremilast Drugs 0.000 description 2
- IMOZEMNVLZVGJZ-QGZVFWFLSA-N apremilast Chemical compound C1=C(OC)C(OCC)=CC([C@@H](CS(C)(=O)=O)N2C(C3=C(NC(C)=O)C=CC=C3C2=O)=O)=C1 IMOZEMNVLZVGJZ-QGZVFWFLSA-N 0.000 description 2
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 description 2
- 229940120638 avastin Drugs 0.000 description 2
- 108010023337 axl receptor tyrosine kinase Proteins 0.000 description 2
- 229940073066 azactam Drugs 0.000 description 2
- 210000003719 b-lymphocyte Anatomy 0.000 description 2
- 230000003385 bacteriostatic effect Effects 0.000 description 2
- 229950007843 bavituximab Drugs 0.000 description 2
- 229940088007 benadryl Drugs 0.000 description 2
- 229950000321 benralizumab Drugs 0.000 description 2
- SRSXLGNVWSONIS-UHFFFAOYSA-M benzenesulfonate Chemical compound [O-]S(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-M 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- PLCQGRYPOISRTQ-LWCNAHDDSA-L betamethasone sodium phosphate Chemical compound [Na+].[Na+].C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COP([O-])([O-])=O)(O)[C@@]1(C)C[C@@H]2O PLCQGRYPOISRTQ-LWCNAHDDSA-L 0.000 description 2
- 229960005354 betamethasone sodium phosphate Drugs 0.000 description 2
- 229940118531 bicillin Drugs 0.000 description 2
- 108091008324 binding proteins Proteins 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000003114 blood coagulation factor Substances 0.000 description 2
- 229940028101 boniva Drugs 0.000 description 2
- 239000005388 borosilicate glass Substances 0.000 description 2
- 210000000481 breast Anatomy 0.000 description 2
- 229940084891 byetta Drugs 0.000 description 2
- 108010018804 c-Mer Tyrosine Kinase Proteins 0.000 description 2
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical class CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 2
- 229940111194 calcitriol injection Drugs 0.000 description 2
- 239000001110 calcium chloride Substances 0.000 description 2
- 229910001628 calcium chloride Inorganic materials 0.000 description 2
- KVUAALJSMIVURS-ZEDZUCNESA-L calcium folinate Chemical compound [Ca+2].C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)C=C1 KVUAALJSMIVURS-ZEDZUCNESA-L 0.000 description 2
- 229940112129 campath Drugs 0.000 description 2
- 229940088954 camptosar Drugs 0.000 description 2
- 229940022399 cancer vaccine Drugs 0.000 description 2
- 238000009566 cancer vaccine Methods 0.000 description 2
- 210000001011 carotid body Anatomy 0.000 description 2
- 229960001139 cefazolin Drugs 0.000 description 2
- MLYYVTUWGNIJIB-BXKDBHETSA-N cefazolin Chemical compound S1C(C)=NN=C1SCC1=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CN3N=NN=C3)[C@H]2SC1 MLYYVTUWGNIJIB-BXKDBHETSA-N 0.000 description 2
- 229960004755 ceftriaxone Drugs 0.000 description 2
- VAAUVRVFOQPIGI-SPQHTLEESA-N ceftriaxone Chemical compound S([C@@H]1[C@@H](C(N1C=1C(O)=O)=O)NC(=O)\C(=N/OC)C=2N=C(N)SC=2)CC=1CSC1=NC(=O)C(=O)NN1C VAAUVRVFOQPIGI-SPQHTLEESA-N 0.000 description 2
- 210000003169 central nervous system Anatomy 0.000 description 2
- 229940029783 cerebyx Drugs 0.000 description 2
- 229960004357 chloramphenicol succinate Drugs 0.000 description 2
- 210000001612 chondrocyte Anatomy 0.000 description 2
- 210000003483 chromatin Anatomy 0.000 description 2
- 229940090100 cimzia Drugs 0.000 description 2
- LOUPRKONTZGTKE-UHFFFAOYSA-N cinchonine Natural products C1C(C(C2)C=C)CCN2C1C(O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-UHFFFAOYSA-N 0.000 description 2
- 229950001565 clazakizumab Drugs 0.000 description 2
- WDDPHFBMKLOVOX-AYQXTPAHSA-N clofarabine Chemical compound C1=NC=2C(N)=NC(Cl)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1F WDDPHFBMKLOVOX-AYQXTPAHSA-N 0.000 description 2
- 238000013037 co-molding Methods 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 229960003346 colistin Drugs 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 229940035811 conjugated estrogen Drugs 0.000 description 2
- 210000002808 connective tissue Anatomy 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 210000000555 contractile cell Anatomy 0.000 description 2
- 229940038717 copaxone Drugs 0.000 description 2
- 229960001970 corticorelin ovine Drugs 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 238000004132 cross linking Methods 0.000 description 2
- 229940021392 cubicin Drugs 0.000 description 2
- 229940094488 cytarabine liposome Drugs 0.000 description 2
- 229960001987 dantrolene Drugs 0.000 description 2
- DOAKLVKFURWEDJ-QCMAZARJSA-N daptomycin Chemical compound C([C@H]1C(=O)O[C@H](C)[C@@H](C(NCC(=O)N[C@@H](CCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@H](CO)C(=O)N[C@H](C(=O)N1)[C@H](C)CC(O)=O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)CCCCCCCCC)C(=O)C1=CC=CC=C1N DOAKLVKFURWEDJ-QCMAZARJSA-N 0.000 description 2
- 229940032301 daptomycin injection Drugs 0.000 description 2
- 229960003603 decitabine Drugs 0.000 description 2
- 229950007998 demcizumab Drugs 0.000 description 2
- 229940075922 depacon Drugs 0.000 description 2
- 229940070968 depocyt Drugs 0.000 description 2
- 229940049377 depodur Drugs 0.000 description 2
- 229960004281 desmopressin Drugs 0.000 description 2
- NFLWUMRGJYTJIN-NXBWRCJVSA-N desmopressin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSCCC(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O)=O)CCC(=O)N)C1=CC=CC=C1 NFLWUMRGJYTJIN-NXBWRCJVSA-N 0.000 description 2
- 230000015155 detection of stimulus involved in sensory perception Effects 0.000 description 2
- 229960000605 dexrazoxane Drugs 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 229960003529 diazepam Drugs 0.000 description 2
- AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 description 2
- 229940004223 digoxin injection Drugs 0.000 description 2
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 2
- 229960002768 dipyridamole Drugs 0.000 description 2
- IZEKFCXSFNUWAM-UHFFFAOYSA-N dipyridamole Chemical compound C=12N=C(N(CCO)CCO)N=C(N3CCCCC3)C2=NC(N(CCO)CCO)=NC=1N1CCCCC1 IZEKFCXSFNUWAM-UHFFFAOYSA-N 0.000 description 2
- LWYLQNWMSGFCOZ-UHFFFAOYSA-L disodium 2,6-bis(propan-2-yl)phenoxymethyl phosphate Chemical compound [Na+].[Na+].CC(C)C1=CC=CC(C(C)C)=C1OCOP([O-])([O-])=O LWYLQNWMSGFCOZ-UHFFFAOYSA-L 0.000 description 2
- CEYUIFJWVHOCPP-UHFFFAOYSA-L disodium;(3-amino-1-hydroxy-1-phosphonatopropyl)phosphonic acid Chemical compound [Na+].[Na+].NCCC(O)(P(O)([O-])=O)P(O)([O-])=O CEYUIFJWVHOCPP-UHFFFAOYSA-L 0.000 description 2
- NJDNXYGOVLYJHP-UHFFFAOYSA-L disodium;2-(3-oxido-6-oxoxanthen-9-yl)benzoate Chemical compound [Na+].[Na+].[O-]C(=O)C1=CC=CC=C1C1=C2C=CC(=O)C=C2OC2=CC([O-])=CC=C21 NJDNXYGOVLYJHP-UHFFFAOYSA-L 0.000 description 2
- 229960003668 docetaxel Drugs 0.000 description 2
- 229960003218 dolasetron mesylate Drugs 0.000 description 2
- 229950000274 domagrozumab Drugs 0.000 description 2
- 229940111539 doribax Drugs 0.000 description 2
- 229960000895 doripenem Drugs 0.000 description 2
- 229960000413 doxercalciferol Drugs 0.000 description 2
- 229940115080 doxil Drugs 0.000 description 2
- 229960004679 doxorubicin Drugs 0.000 description 2
- 229950003468 dupilumab Drugs 0.000 description 2
- 229940073153 duraclon Drugs 0.000 description 2
- 108010011867 ecallantide Proteins 0.000 description 2
- 239000013013 elastic material Substances 0.000 description 2
- 239000000806 elastomer Substances 0.000 description 2
- 229960002856 eliglustat Drugs 0.000 description 2
- GBXSMTUPTTWBMN-XIRDDKMYSA-N enalapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(O)=O)CC1=CC=CC=C1 GBXSMTUPTTWBMN-XIRDDKMYSA-N 0.000 description 2
- 229960000873 enalapril Drugs 0.000 description 2
- PEASPLKKXBYDKL-FXEVSJAOSA-N enfuvirtide Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(C)=O)[C@@H](C)O)[C@@H](C)CC)C1=CN=CN1 PEASPLKKXBYDKL-FXEVSJAOSA-N 0.000 description 2
- 239000003623 enhancer Substances 0.000 description 2
- 229960000610 enoxaparin Drugs 0.000 description 2
- 201000010063 epididymitis Diseases 0.000 description 2
- 230000001973 epigenetic effect Effects 0.000 description 2
- 229940089602 epinephrine injection Drugs 0.000 description 2
- 210000000981 epithelium Anatomy 0.000 description 2
- 229960001123 epoprostenol Drugs 0.000 description 2
- KAQKFAOMNZTLHT-VVUHWYTRSA-N epoprostenol Chemical compound O1C(=CCCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 KAQKFAOMNZTLHT-VVUHWYTRSA-N 0.000 description 2
- 229930013356 epothilone Natural products 0.000 description 2
- 229960002770 ertapenem Drugs 0.000 description 2
- 239000003797 essential amino acid Substances 0.000 description 2
- 235000020776 essential amino acid Nutrition 0.000 description 2
- 229960005309 estradiol Drugs 0.000 description 2
- 108091008559 estrogen-related receptor alpha Proteins 0.000 description 2
- 229960000403 etanercept Drugs 0.000 description 2
- 229920000840 ethylene tetrafluoroethylene copolymer Polymers 0.000 description 2
- 210000000632 euchromatin Anatomy 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 238000013265 extended release Methods 0.000 description 2
- 210000002744 extracellular matrix Anatomy 0.000 description 2
- 229940005526 famotidine injection Drugs 0.000 description 2
- 229940126864 fibroblast growth factor Drugs 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 2
- 229940044117 fluorodeoxyglucose f18 Drugs 0.000 description 2
- 229940110945 follitropin beta injection Drugs 0.000 description 2
- 229960000848 foscarnet sodium Drugs 0.000 description 2
- 229960001934 fosphenytoin sodium Drugs 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 229950004003 fresolimumab Drugs 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 229950002140 futuximab Drugs 0.000 description 2
- 229940075342 gadoxetate disodium Drugs 0.000 description 2
- 229960003692 gamma aminobutyric acid Drugs 0.000 description 2
- GJNXBNATEDXMAK-PFLSVRRQSA-N ganirelix Chemical compound C([C@@H](C(=O)N[C@H](CCCCN=C(NCC)NCC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN=C(NCC)NCC)C(=O)N1[C@@H](CCC1)C(=O)N[C@H](C)C(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC=1C=NC=CC=1)NC(=O)[C@@H](CC=1C=CC(Cl)=CC=1)NC(=O)[C@@H](CC=1C=C2C=CC=CC2=CC=1)NC(C)=O)C1=CC=C(O)C=C1 GJNXBNATEDXMAK-PFLSVRRQSA-N 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 210000001156 gastric mucosa Anatomy 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 229960000578 gemtuzumab Drugs 0.000 description 2
- 230000009368 gene silencing by RNA Effects 0.000 description 2
- 229950003717 gevokizumab Drugs 0.000 description 2
- GNKDKYIHGQKHHM-RJKLHVOGSA-N ghrelin Chemical compound C([C@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CN)COC(=O)CCCCCCC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C1=CC=CC=C1 GNKDKYIHGQKHHM-RJKLHVOGSA-N 0.000 description 2
- 230000000762 glandular Effects 0.000 description 2
- 229940057854 gonal f Drugs 0.000 description 2
- 229960003607 granisetron hydrochloride Drugs 0.000 description 2
- 229920000669 heparin Polymers 0.000 description 2
- 229940022353 herceptin Drugs 0.000 description 2
- 108091008039 hormone receptors Proteins 0.000 description 2
- 102000045921 human GAA Human genes 0.000 description 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- WVLOADHCBXTIJK-YNHQPCIGSA-N hydromorphone Chemical compound O([C@H]1C(CC[C@H]23)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O WVLOADHCBXTIJK-YNHQPCIGSA-N 0.000 description 2
- QYZRTBKYBJRGJB-UHFFFAOYSA-N hydron;1-methyl-n-(9-methyl-9-azabicyclo[3.3.1]nonan-3-yl)indazole-3-carboxamide;chloride Chemical compound Cl.C1=CC=C2C(C(=O)NC3CC4CCCC(C3)N4C)=NN(C)C2=C1 QYZRTBKYBJRGJB-UHFFFAOYSA-N 0.000 description 2
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 description 2
- 229960001680 ibuprofen Drugs 0.000 description 2
- 229940071829 ilaris Drugs 0.000 description 2
- 229940102223 injectable solution Drugs 0.000 description 2
- 238000001746 injection moulding Methods 0.000 description 2
- 229960000367 inositol Drugs 0.000 description 2
- 229940125396 insulin Drugs 0.000 description 2
- PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 description 2
- 108700039926 insulin glulisine Proteins 0.000 description 2
- 108010054372 insulin receptor-related receptor Proteins 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 229940065638 intron a Drugs 0.000 description 2
- PDWUPXJEEYOOTR-IUAIQHPESA-N iobenguane (123I) Chemical compound NC(N)=NCC1=CC=CC([123I])=C1 PDWUPXJEEYOOTR-IUAIQHPESA-N 0.000 description 2
- DGAIEPBNLOQYER-UHFFFAOYSA-N iopromide Chemical compound COCC(=O)NC1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)N(C)CC(O)CO)=C1I DGAIEPBNLOQYER-UHFFFAOYSA-N 0.000 description 2
- 229960004537 ioversol Drugs 0.000 description 2
- 229960000779 irinotecan hydrochloride Drugs 0.000 description 2
- 229910052742 iron Inorganic materials 0.000 description 2
- 229960004130 itraconazole Drugs 0.000 description 2
- VBGWSQKGUZHFPS-VGMMZINCSA-N kalbitor Chemical compound C([C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]2C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=3C=CC=CC=3)C(=O)N[C@H](C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)NCC(=O)NCC(=O)N[C@H]3CSSC[C@H](NC(=O)[C@@H]4CCCN4C(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CO)NC(=O)[C@H](CC=4NC=NC=4)NC(=O)[C@H](CCSC)NC(=O)[C@H](C)NC(=O)[C@@H](N)CCC(O)=O)CSSC[C@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC3=O)CSSC2)C(=O)N[C@@H]([C@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=2NC=NC=2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N1)[C@@H](C)CC)[C@H](C)O)=O)[C@@H](C)CC)C1=CC=CC=C1 VBGWSQKGUZHFPS-VGMMZINCSA-N 0.000 description 2
- 229940018902 kalbitor Drugs 0.000 description 2
- 229950000518 labetuzumab Drugs 0.000 description 2
- 229960002623 lacosamide Drugs 0.000 description 2
- VPPJLAIAVCUEMN-GFCCVEGCSA-N lacosamide Chemical compound COC[C@@H](NC(C)=O)C(=O)NCC1=CC=CC=C1 VPPJLAIAVCUEMN-GFCCVEGCSA-N 0.000 description 2
- MJIHNNLFOKEZEW-UHFFFAOYSA-N lansoprazole Chemical compound CC1=C(OCC(F)(F)F)C=CN=C1CS(=O)C1=NC2=CC=CC=C2N1 MJIHNNLFOKEZEW-UHFFFAOYSA-N 0.000 description 2
- 229960003174 lansoprazole Drugs 0.000 description 2
- 229940060975 lantus Drugs 0.000 description 2
- 210000003644 lens cell Anatomy 0.000 description 2
- 229940039781 leptin Drugs 0.000 description 2
- NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical compound O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 description 2
- 229960004338 leuprorelin Drugs 0.000 description 2
- 229960004002 levetiracetam Drugs 0.000 description 2
- HPHUVLMMVZITSG-ZCFIWIBFSA-N levetiracetam Chemical compound CC[C@H](C(N)=O)N1CCCC1=O HPHUVLMMVZITSG-ZCFIWIBFSA-N 0.000 description 2
- 229950009923 ligelizumab Drugs 0.000 description 2
- 229960003907 linezolid Drugs 0.000 description 2
- TYZROVQLWOKYKF-ZDUSSCGKSA-N linezolid Chemical compound O=C1O[C@@H](CNC(=O)C)CN1C(C=C1F)=CC=C1N1CCOCC1 TYZROVQLWOKYKF-ZDUSSCGKSA-N 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 210000005265 lung cell Anatomy 0.000 description 2
- 229940065268 lusedra Drugs 0.000 description 2
- 102000049853 macrophage stimulating protein Human genes 0.000 description 2
- 108010053292 macrophage stimulating protein Proteins 0.000 description 2
- 210000003593 megakaryocyte Anatomy 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- HOVAGTYPODGVJG-PZRMXXKTSA-N methyl alpha-D-galactoside Chemical compound CO[C@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O HOVAGTYPODGVJG-PZRMXXKTSA-N 0.000 description 2
- 229960001293 methylprednisolone acetate Drugs 0.000 description 2
- TTWJBBZEZQICBI-UHFFFAOYSA-N metoclopramide Chemical compound CCN(CC)CCNC(=O)C1=CC(Cl)=C(N)C=C1OC TTWJBBZEZQICBI-UHFFFAOYSA-N 0.000 description 2
- 229940116859 metoclopramide injection Drugs 0.000 description 2
- 229960000282 metronidazole Drugs 0.000 description 2
- 210000000110 microvilli Anatomy 0.000 description 2
- 229940116843 minocycline injection Drugs 0.000 description 2
- 229960001156 mitoxantrone Drugs 0.000 description 2
- KKZJGLLVHKMTCM-UHFFFAOYSA-N mitoxantrone Chemical compound O=C1C2=C(O)C=CC(O)=C2C(=O)C2=C1C(NCCNCCO)=CC=C2NCCNCCO KKZJGLLVHKMTCM-UHFFFAOYSA-N 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- 229940068938 morphine injection Drugs 0.000 description 2
- 230000000921 morphogenic effect Effects 0.000 description 2
- 229950003968 motesanib Drugs 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 229940074923 mozobil Drugs 0.000 description 2
- 210000003550 mucous cell Anatomy 0.000 description 2
- JORAUNFTUVJTNG-BSTBCYLQSA-N n-[(2s)-4-amino-1-[[(2s,3r)-1-[[(2s)-4-amino-1-oxo-1-[[(3s,6s,9s,12s,15r,18s,21s)-6,9,18-tris(2-aminoethyl)-3-[(1r)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-h Chemical compound CC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O JORAUNFTUVJTNG-BSTBCYLQSA-N 0.000 description 2
- 229940092138 nafcillin injection Drugs 0.000 description 2
- 229960001775 nafcillin sodium Drugs 0.000 description 2
- OCXSDHJRMYFTMA-KMFBOIRUSA-M nafcillin sodium monohydrate Chemical compound O.[Na+].C1=CC=CC2=C(C(=O)N[C@@H]3C(N4[C@H](C(C)(C)S[C@@H]43)C([O-])=O)=O)C(OCC)=CC=C21 OCXSDHJRMYFTMA-KMFBOIRUSA-M 0.000 description 2
- DQCKKXVULJGBQN-XFWGSAIBSA-N naltrexone Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=O)O)CC1)O)CC1CC1 DQCKKXVULJGBQN-XFWGSAIBSA-N 0.000 description 2
- 239000002121 nanofiber Substances 0.000 description 2
- 229940068808 neoprofen Drugs 0.000 description 2
- OSZNNLWOYWAHSS-UHFFFAOYSA-M neostigmine methyl sulfate Chemical compound COS([O-])(=O)=O.CN(C)C(=O)OC1=CC=CC([N+](C)(C)C)=C1 OSZNNLWOYWAHSS-UHFFFAOYSA-M 0.000 description 2
- 229940101041 nephramine Drugs 0.000 description 2
- 230000003227 neuromodulating effect Effects 0.000 description 2
- 229960003347 obinutuzumab Drugs 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- KVWDHTXUZHCGIO-UHFFFAOYSA-N olanzapine Chemical compound C1CN(C)CCN1C1=NC2=CC=CC=C2NC2=C1C=C(C)S2 KVWDHTXUZHCGIO-UHFFFAOYSA-N 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 230000010355 oscillation Effects 0.000 description 2
- 229940064457 osmitrol Drugs 0.000 description 2
- 229940112876 ovidrel Drugs 0.000 description 2
- UWYHMGVUTGAWSP-JKIFEVAISA-N oxacillin Chemical compound N([C@@H]1C(N2[C@H](C(C)(C)S[C@@H]21)C(O)=O)=O)C(=O)C1=C(C)ON=C1C1=CC=CC=C1 UWYHMGVUTGAWSP-JKIFEVAISA-N 0.000 description 2
- 229960001019 oxacillin Drugs 0.000 description 2
- XNOPRXBHLZRZKH-MQYCRUOZSA-N oxytocin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1C(CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-MQYCRUOZSA-N 0.000 description 2
- 229940082408 oxytocin injection Drugs 0.000 description 2
- 229940114601 panitumumab injection Drugs 0.000 description 2
- 229960003207 papaverine hydrochloride Drugs 0.000 description 2
- 229950005079 perakizumab Drugs 0.000 description 2
- 230000000737 periodic effect Effects 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- 210000002856 peripheral neuron Anatomy 0.000 description 2
- 108091008725 peroxisome proliferator-activated receptors alpha Proteins 0.000 description 2
- 108091008765 peroxisome proliferator-activated receptors β/δ Proteins 0.000 description 2
- 229960002292 piperacillin Drugs 0.000 description 2
- WCMIIGXFCMNQDS-IDYPWDAWSA-M piperacillin sodium Chemical compound [Na+].O=C1C(=O)N(CC)CCN1C(=O)N[C@H](C=1C=CC=CC=1)C(=O)N[C@@H]1C(=O)N2[C@@H](C([O-])=O)C(C)(C)S[C@@H]21 WCMIIGXFCMNQDS-IDYPWDAWSA-M 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- YIQPUIGJQJDJOS-UHFFFAOYSA-N plerixafor Chemical compound C=1C=C(CN2CCNCCCNCCNCCC2)C=CC=1CN1CCCNCCNCCCNCC1 YIQPUIGJQJDJOS-UHFFFAOYSA-N 0.000 description 2
- 229940025913 polidocanol injection Drugs 0.000 description 2
- 229920001084 poly(chloroprene) Polymers 0.000 description 2
- 229920002530 polyetherether ketone Polymers 0.000 description 2
- KNIWPHSUTGNZST-UHFFFAOYSA-N polymyxin E2 Natural products CC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O KNIWPHSUTGNZST-UHFFFAOYSA-N 0.000 description 2
- 229920001184 polypeptide Polymers 0.000 description 2
- 229920002620 polyvinyl fluoride Polymers 0.000 description 2
- 239000001103 potassium chloride Substances 0.000 description 2
- 235000011164 potassium chloride Nutrition 0.000 description 2
- 108010029667 pramlintide Proteins 0.000 description 2
- 229940071643 prefilled syringe Drugs 0.000 description 2
- 238000003825 pressing Methods 0.000 description 2
- 229940027836 primaxin Drugs 0.000 description 2
- 239000000186 progesterone Substances 0.000 description 2
- 229960003387 progesterone Drugs 0.000 description 2
- 229960004604 propranolol hydrochloride Drugs 0.000 description 2
- AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol hydrochloride Natural products C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 description 2
- 150000003180 prostaglandins Chemical class 0.000 description 2
- GPTFURBXHJWNHR-UHFFFAOYSA-N protopine Chemical compound C1=C2C(=O)CC3=CC=C4OCOC4=C3CN(C)CCC2=CC2=C1OCO2 GPTFURBXHJWNHR-UHFFFAOYSA-N 0.000 description 2
- 235000008160 pyridoxine Nutrition 0.000 description 2
- 239000011677 pyridoxine Substances 0.000 description 2
- 229960000948 quinine Drugs 0.000 description 2
- GGWBHVILAJZWKJ-KJEVSKRMSA-N ranitidine hydrochloride Chemical compound [H+].[Cl-].[O-][N+](=O)\C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 GGWBHVILAJZWKJ-KJEVSKRMSA-N 0.000 description 2
- 229960001520 ranitidine hydrochloride Drugs 0.000 description 2
- 229940114241 recombivax Drugs 0.000 description 2
- 229960003614 regadenoson Drugs 0.000 description 2
- LZPZPHGJDAGEJZ-AKAIJSEGSA-N regadenoson Chemical compound C1=C(C(=O)NC)C=NN1C1=NC(N)=C(N=CN2[C@H]3[C@@H]([C@H](O)[C@@H](CO)O3)O)C2=N1 LZPZPHGJDAGEJZ-AKAIJSEGSA-N 0.000 description 2
- 210000001995 reticulocyte Anatomy 0.000 description 2
- 108091008726 retinoic acid receptors α Proteins 0.000 description 2
- 108091008761 retinoic acid receptors β Proteins 0.000 description 2
- OHRURASPPZQGQM-GCCNXGTGSA-N romidepsin Chemical compound O1C(=O)[C@H](C(C)C)NC(=O)C(=C/C)/NC(=O)[C@H]2CSSCC\C=C\[C@@H]1CC(=O)N[C@H](C(C)C)C(=O)N2 OHRURASPPZQGQM-GCCNXGTGSA-N 0.000 description 2
- OHRURASPPZQGQM-UHFFFAOYSA-N romidepsin Natural products O1C(=O)C(C(C)C)NC(=O)C(=CC)NC(=O)C2CSSCCC=CC1CC(=O)NC(C(C)C)C(=O)N2 OHRURASPPZQGQM-UHFFFAOYSA-N 0.000 description 2
- 108010091666 romidepsin Proteins 0.000 description 2
- 210000003079 salivary gland Anatomy 0.000 description 2
- 210000000697 sensory organ Anatomy 0.000 description 2
- 230000019491 signal transduction Effects 0.000 description 2
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 2
- 239000004299 sodium benzoate Substances 0.000 description 2
- 235000010234 sodium benzoate Nutrition 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000001540 sodium lactate Substances 0.000 description 2
- 235000011088 sodium lactate Nutrition 0.000 description 2
- 229940005581 sodium lactate Drugs 0.000 description 2
- 229940006198 sodium phenylacetate Drugs 0.000 description 2
- AEQFSUDEHCCHBT-UHFFFAOYSA-M sodium valproate Chemical compound [Na+].CCCC(C([O-])=O)CCC AEQFSUDEHCCHBT-UHFFFAOYSA-M 0.000 description 2
- 229940084026 sodium valproate Drugs 0.000 description 2
- TUPFOYXHAYOHIB-YCAIQWGJSA-M sodium;(2s,5r,6r)-6-[[(2r)-2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate;(2s,3s,5r)-3-methyl-4,4,7-trioxo-3-(triazol-1-ylmethyl)-4$l^{6}-thia-1-azabicyclo[3.2.0]h Chemical compound [Na+].C([C@]1(C)S([C@H]2N(C(C2)=O)[C@H]1C(O)=O)(=O)=O)N1C=CN=N1.O=C1C(=O)N(CC)CCN1C(=O)N[C@H](C=1C=CC=CC=1)C(=O)N[C@@H]1C(=O)N2[C@@H](C([O-])=O)C(C)(C)S[C@@H]21 TUPFOYXHAYOHIB-YCAIQWGJSA-M 0.000 description 2
- RMLUKZWYIKEASN-UHFFFAOYSA-M sodium;2-amino-9-(2-hydroxyethoxymethyl)purin-6-olate Chemical compound [Na+].O=C1[N-]C(N)=NC2=C1N=CN2COCCO RMLUKZWYIKEASN-UHFFFAOYSA-M 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 229960004532 somatropin Drugs 0.000 description 2
- 230000000087 stabilizing effect Effects 0.000 description 2
- 229920003048 styrene butadiene rubber Polymers 0.000 description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
- 229960001204 sufentanil citrate Drugs 0.000 description 2
- 229940097432 sumatriptan injection Drugs 0.000 description 2
- 210000000106 sweat gland Anatomy 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- 229940063683 taxotere Drugs 0.000 description 2
- LPQZKKCYTLCDGQ-WEDXCCLWSA-N tazobactam Chemical compound C([C@]1(C)S([C@H]2N(C(C2)=O)[C@H]1C(O)=O)(=O)=O)N1C=CN=N1 LPQZKKCYTLCDGQ-WEDXCCLWSA-N 0.000 description 2
- 229960003865 tazobactam Drugs 0.000 description 2
- 108010089019 telavancin Proteins 0.000 description 2
- OGBMKVWORPGQRR-UMXFMPSGSA-N teriparatide Chemical compound C([C@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CNC=N1 OGBMKVWORPGQRR-UMXFMPSGSA-N 0.000 description 2
- 210000001550 testis Anatomy 0.000 description 2
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 description 2
- 229920006342 thermoplastic vulcanizate Polymers 0.000 description 2
- 108091008762 thyroid hormone receptors ß Proteins 0.000 description 2
- 108091008763 thyroid hormone receptors α Proteins 0.000 description 2
- XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 description 2
- 210000002105 tongue Anatomy 0.000 description 2
- 229960005267 tositumomab Drugs 0.000 description 2
- 230000005026 transcription initiation Effects 0.000 description 2
- 229940066958 treanda Drugs 0.000 description 2
- 229940032510 trelstar Drugs 0.000 description 2
- GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 description 2
- 229960002117 triamcinolone acetonide Drugs 0.000 description 2
- 210000002993 trophoblast Anatomy 0.000 description 2
- 102000003298 tumor necrosis factor receptor Human genes 0.000 description 2
- QTFFGPOXNNGTGZ-RCSCTSIBSA-N u3c8e5bwkr Chemical compound O.CS(O)(=O)=O.C1=CC=C2C(C(OC3C[C@@H]4CC5C[C@@H](N4CC5=O)C3)=O)=CNC2=C1 QTFFGPOXNNGTGZ-RCSCTSIBSA-N 0.000 description 2
- BNJNAEJASPUJTO-DUOHOMBCSA-N vadastuximab talirine Chemical compound COc1ccc(cc1)C2=CN3[C@@H](C2)C=Nc4cc(OCCCOc5cc6N=C[C@@H]7CC(=CN7C(=O)c6cc5OC)c8ccc(NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)CCCCCN9C(=O)C[C@@H](SC[C@H](N)C(=O)O)C9=O)C(C)C)cc8)c(OC)cc4C3=O BNJNAEJASPUJTO-DUOHOMBCSA-N 0.000 description 2
- 229960004914 vedolizumab Drugs 0.000 description 2
- 229940035081 venofer Drugs 0.000 description 2
- YTZALCGQUPRCGW-ZSFNYQMMSA-N verteporfin Chemical compound N1C(C=C2C(=C(CCC(O)=O)C(C=C3C(CCC(=O)OC)=C(C)C(N3)=C3)=N2)C)=C(C=C)C(C)=C1C=C1C2=CC=C(C(=O)OC)[C@@H](C(=O)OC)[C@@]2(C)C3=N1 YTZALCGQUPRCGW-ZSFNYQMMSA-N 0.000 description 2
- 229960004982 vinblastine sulfate Drugs 0.000 description 2
- KDQAABAKXDWYSZ-PNYVAJAMSA-N vinblastine sulfate Chemical compound OS(O)(=O)=O.C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 KDQAABAKXDWYSZ-PNYVAJAMSA-N 0.000 description 2
- 230000003612 virological effect Effects 0.000 description 2
- 229940011671 vitamin b6 Drugs 0.000 description 2
- HBOMLICNUCNMMY-XLPZGREQSA-N zidovudine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](N=[N+]=[N-])C1 HBOMLICNUCNMMY-XLPZGREQSA-N 0.000 description 2
- UVJDUBUJJFBKLD-UHFFFAOYSA-L zinc;2-[bis[2-[bis(carboxylatomethyl)amino]ethyl]amino]acetate;hydron Chemical compound [H+].[H+].[H+].[Zn+2].[O-]C(=O)CN(CC([O-])=O)CCN(CC(=O)[O-])CCN(CC([O-])=O)CC([O-])=O UVJDUBUJJFBKLD-UHFFFAOYSA-L 0.000 description 2
- 229940104666 zosyn Drugs 0.000 description 2
- DNXHEGUUPJUMQT-UHFFFAOYSA-N (+)-estrone Natural products OC1=CC=C2C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 DNXHEGUUPJUMQT-UHFFFAOYSA-N 0.000 description 1
- XWTYSIMOBUGWOL-UHFFFAOYSA-N (+-)-Terbutaline Chemical compound CC(C)(C)NCC(O)C1=CC(O)=CC(O)=C1 XWTYSIMOBUGWOL-UHFFFAOYSA-N 0.000 description 1
- NGGMYCMLYOUNGM-UHFFFAOYSA-N (-)-fumagillin Natural products O1C(CC=C(C)C)C1(C)C1C(OC)C(OC(=O)C=CC=CC=CC=CC(O)=O)CCC21CO2 NGGMYCMLYOUNGM-UHFFFAOYSA-N 0.000 description 1
- CRDAMVZIKSXKFV-FBXUGWQNSA-N (2-cis,6-cis)-farnesol Chemical compound CC(C)=CCC\C(C)=C/CC\C(C)=C/CO CRDAMVZIKSXKFV-FBXUGWQNSA-N 0.000 description 1
- 239000000260 (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol Substances 0.000 description 1
- NQUUPTGRJYIXSL-YPDXTJLXSA-N (2R)-3-[(3R)-1-[3-[2-[2-[2-[2-[2-[2-[2-[2-[3-[[(2S)-1-[[(2S)-1-[4-[[(6S,6aS)-3-[5-[[(6aS)-2-methoxy-8-methyl-11-oxo-6a,7-dihydropyrrolo[2,1-c][1,4]benzodiazepin-3-yl]oxy]pentoxy]-6-hydroxy-2-methoxy-8-methyl-11-oxo-6a,7-dihydro-6H-pyrrolo[2,1-c][1,4]benzodiazepine-5-carbonyl]oxymethyl]anilino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethylamino]-3-oxopropyl]-2,5-dioxopyrrolidin-3-yl]sulfanyl-2-aminopropanoic acid Chemical compound COc1cc2c(cc1OCCCCCOc1cc3N([C@@H](O)[C@@H]4CC(C)=CN4C(=O)c3cc1OC)C(=O)OCc1ccc(NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCN3C(=O)C[C@@H](SC[C@H](N)C(O)=O)C3=O)C(C)C)cc1)N=C[C@@H]1CC(C)=CN1C2=O NQUUPTGRJYIXSL-YPDXTJLXSA-N 0.000 description 1
- KXNPVXPOPUZYGB-IOVMHBDKSA-N (2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]-1-oxopentyl]-4-methyl-2-piperidinecarboxylic acid Chemical compound OC(=O)[C@H]1C[C@H](C)CCN1C(=O)[C@H](CCCN=C(N)N)NS(=O)(=O)C1=CC=CC2=C1NCC(C)C2 KXNPVXPOPUZYGB-IOVMHBDKSA-N 0.000 description 1
- FOIAQXXUVRINCI-LBAQZLPGSA-N (2S)-2-amino-6-[[4-[2-[bis(carboxymethyl)amino]-3-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]propyl]phenyl]carbamothioylamino]hexanoic acid Chemical compound N[C@@H](CCCCNC(=S)Nc1ccc(CC(CN(CCN(CC(O)=O)CC(O)=O)CC(O)=O)N(CC(O)=O)CC(O)=O)cc1)C(O)=O FOIAQXXUVRINCI-LBAQZLPGSA-N 0.000 description 1
- PGOHTUIFYSHAQG-LJSDBVFPSA-N (2S)-6-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-1-[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-sulfanylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoyl]amino]hexanoic acid Chemical compound CSCC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O PGOHTUIFYSHAQG-LJSDBVFPSA-N 0.000 description 1
- RDEIXVOBVLKYNT-VQBXQJRRSA-N (2r,3r,4r,5r)-2-[(1s,2s,3r,4s,6r)-4,6-diamino-3-[(2r,3r,6s)-3-amino-6-(1-aminoethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;(2r,3r,4r,5r)-2-[(1s,2s,3r,4s,6r)-4,6-diamino-3-[(2r,3r,6s)-3-amino-6-(aminomethyl)oxan-2-yl]o Chemical compound OS(O)(=O)=O.O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC[C@@H](CN)O2)N)[C@@H](N)C[C@H]1N.O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC[C@H](O2)C(C)N)N)[C@@H](N)C[C@H]1N.O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N RDEIXVOBVLKYNT-VQBXQJRRSA-N 0.000 description 1
- ZDRRIRUAESZNIH-BZGUUIOASA-N (2s)-1-[(4r,7s,10s,13s,16s,19r)-19-amino-7-(2-amino-2-oxoethyl)-13-[(2s)-butan-2-yl]-10-[(1r)-1-hydroxyethyl]-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-n-[(2s)-1-[(2-amino-2-oxoethyl)amino]- Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)[C@@H](C)O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZDRRIRUAESZNIH-BZGUUIOASA-N 0.000 description 1
- ZMEWRPBAQVSBBB-GOTSBHOMSA-N (2s)-2-[[(2s)-2-[(2-aminoacetyl)amino]-3-(4-hydroxyphenyl)propanoyl]amino]-6-[[2-[2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetyl]amino]hexanoic acid Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC(=O)NCCCC[C@@H](C(O)=O)NC(=O)[C@@H](NC(=O)CN)CC1=CC=C(O)C=C1 ZMEWRPBAQVSBBB-GOTSBHOMSA-N 0.000 description 1
- YLOCGHYTXIINAI-XKUOMLDTSA-N (2s)-2-amino-3-(4-hydroxyphenyl)propanoic acid;(2s)-2-aminopentanedioic acid;(2s)-2-aminopropanoic acid;(2s)-2,6-diaminohexanoic acid Chemical compound C[C@H](N)C(O)=O.NCCCC[C@H](N)C(O)=O.OC(=O)[C@@H](N)CCC(O)=O.OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 YLOCGHYTXIINAI-XKUOMLDTSA-N 0.000 description 1
- ZBVJFYPGLGEMIN-OYLNGHKZSA-N (2s)-n-[(2s)-1-[[(2s)-1-[[(2s)-1-[[(2s)-1-[[(2r)-1-[[(2s)-1-[[(2s)-1-[(2s)-2-[(2-amino-2-oxoethyl)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1h-indol-3-yl)-1-oxopropan-2-yl]amino]-3-( Chemical compound C1=CC=C2C(CC=3C4=CC=CC=C4C=C(C=3O)C(=O)O)=C(O)C(C(O)=O)=CC2=C1.C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 ZBVJFYPGLGEMIN-OYLNGHKZSA-N 0.000 description 1
- ZOPNBMMVVZRSGH-NRFANRHFSA-N (3s)-3-[4-[[3-[4-(trifluoromethyl)phenyl]phenyl]methoxy]phenyl]hex-4-ynoic acid Chemical compound C1=CC([C@H](CC(O)=O)C#CC)=CC=C1OCC1=CC=CC(C=2C=CC(=CC=2)C(F)(F)F)=C1 ZOPNBMMVVZRSGH-NRFANRHFSA-N 0.000 description 1
- 239000001096 (4-ethenyl-1-azabicyclo[2.2.2]octan-7-yl)-(6-methoxyquinolin-4-yl)methanol hydrochloride Substances 0.000 description 1
- YCNCXQNUXCHRRX-ZHPDPMBESA-N (5s)-2-[[(1r,3s,4s)-3-bicyclo[2.2.1]heptanyl]amino]-5-methyl-5-propan-2-yl-1,3-thiazol-4-one Chemical compound N([C@@H]1[C@@]2([H])CC[C@](C2)(C1)[H])C1=NC(=O)[C@](C)(C(C)C)S1 YCNCXQNUXCHRRX-ZHPDPMBESA-N 0.000 description 1
- MMRINLZOZVAPDZ-LSGRDSQZSA-N (6r,7r)-7-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(1-methylpyrrolidin-1-ium-1-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;chloride Chemical compound Cl.S([C@@H]1[C@@H](C(N1C=1C([O-])=O)=O)NC(=O)\C(=N/OC)C=2N=C(N)SC=2)CC=1C[N+]1(C)CCCC1 MMRINLZOZVAPDZ-LSGRDSQZSA-N 0.000 description 1
- XHKUDCCTVQUHJQ-BILMMMPYSA-N (r)-[(2s,4s,5r)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol;(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C([C@H]([C@H](C1)C=C)C2)CN1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21 XHKUDCCTVQUHJQ-BILMMMPYSA-N 0.000 description 1
- NNKXWRRDHYTHFP-HZQSTTLBSA-N (r)-[(2s,4s,5r)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol;hydron;dichloride Chemical compound Cl.Cl.C([C@H]([C@H](C1)C=C)C2)CN1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21 NNKXWRRDHYTHFP-HZQSTTLBSA-N 0.000 description 1
- NCCJWSXETVVUHK-ZYSAIPPVSA-N (z)-7-[(2r)-2-amino-2-carboxyethyl]sulfanyl-2-[[(1s)-2,2-dimethylcyclopropanecarbonyl]amino]hept-2-enoic acid;(5r,6s)-3-[2-(aminomethylideneamino)ethylsulfanyl]-6-[(1r)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid Chemical compound C1C(SCC\N=C/N)=C(C(O)=O)N2C(=O)[C@H]([C@H](O)C)[C@H]21.CC1(C)C[C@@H]1C(=O)N\C(=C/CCCCSC[C@H](N)C(O)=O)C(O)=O NCCJWSXETVVUHK-ZYSAIPPVSA-N 0.000 description 1
- 102000001556 1-Phosphatidylinositol 4-Kinase Human genes 0.000 description 1
- 108010029190 1-Phosphatidylinositol 4-Kinase Proteins 0.000 description 1
- IBDOVKSLMMFQPJ-IUPOGUASSA-N 1-[2-[(4ar,11r,11as)-11-methyl-9-(trifluoromethyl)-1,3,4,4a,5,6,11,11a-octahydropyrido[4,3-b]carbazol-2-yl]ethyl]cyclohexane-1-carboxylic acid;benzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=CC=C1.C([C@@H]1[C@H](C=2C3=CC(=CC=C3NC=2C[C@H]1CC1)C(F)(F)F)C)N1CCC1(C(O)=O)CCCCC1 IBDOVKSLMMFQPJ-IUPOGUASSA-N 0.000 description 1
- ZOHXWSHGANNQGO-DSIKUUPMSA-N 1-amino-4-[[5-[[(2S)-1-[[(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl]oxy]-1-oxopropan-2-yl]-methylamino]-2-methyl-5-oxopentan-2-yl]disulfanyl]-1-oxobutane-2-sulfonic acid Chemical compound CO[C@@H]([C@@]1(O)C[C@H](OC(=O)N1)[C@@H](C)[C@@H]1O[C@@]1(C)[C@@H](OC(=O)[C@H](C)N(C)C(=O)CCC(C)(C)SSCCC(C(N)=O)S(O)(=O)=O)CC(=O)N1C)\C=C\C=C(C)\CC2=CC(OC)=C(Cl)C1=C2 ZOHXWSHGANNQGO-DSIKUUPMSA-N 0.000 description 1
- LEBVLXFERQHONN-UHFFFAOYSA-N 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Chemical compound CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-UHFFFAOYSA-N 0.000 description 1
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 description 1
- ZJNLYGOUHDJHMG-UHFFFAOYSA-N 1-n,4-n-bis(5-methylhexan-2-yl)benzene-1,4-diamine Chemical compound CC(C)CCC(C)NC1=CC=C(NC(C)CCC(C)C)C=C1 ZJNLYGOUHDJHMG-UHFFFAOYSA-N 0.000 description 1
- 102100036933 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor Human genes 0.000 description 1
- BPKAHTKRCLCHEA-FOPGHSPUSA-N 19-Nor-1-α,25-dihydroxyvitamin D2 Chemical compound C1([C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](C=C[C@H](C)C(C)(C)O)C)=CC=C1C[C@@H](O)C[C@H](O)C1 BPKAHTKRCLCHEA-FOPGHSPUSA-N 0.000 description 1
- KGRVJHAUYBGFFP-UHFFFAOYSA-N 2,2'-Methylenebis(4-methyl-6-tert-butylphenol) Chemical compound CC(C)(C)C1=CC(C)=CC(CC=2C(=C(C=C(C)C=2)C(C)(C)C)O)=C1O KGRVJHAUYBGFFP-UHFFFAOYSA-N 0.000 description 1
- YABFPHSQTSFWQB-UHFFFAOYSA-N 2-(4-fluorophenyl)-1-(1,2,4-triazol-1-yl)-3-(trimethylsilyl)propan-2-ol Chemical compound C=1C=C(F)C=CC=1C(O)(C[Si](C)(C)C)CN1C=NC=N1 YABFPHSQTSFWQB-UHFFFAOYSA-N 0.000 description 1
- VTAKZNRDSPNOAU-UHFFFAOYSA-M 2-(chloromethyl)oxirane;hydron;prop-2-en-1-amine;n-prop-2-enyldecan-1-amine;trimethyl-[6-(prop-2-enylamino)hexyl]azanium;dichloride Chemical compound Cl.[Cl-].NCC=C.ClCC1CO1.CCCCCCCCCCNCC=C.C[N+](C)(C)CCCCCCNCC=C VTAKZNRDSPNOAU-UHFFFAOYSA-M 0.000 description 1
- PYTMYKVIJXPNBD-OQKDUQJOSA-N 2-[4-[(z)-2-chloro-1,2-diphenylethenyl]phenoxy]-n,n-diethylethanamine;hydron;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.C1=CC(OCCN(CC)CC)=CC=C1C(\C=1C=CC=CC=1)=C(/Cl)C1=CC=CC=C1 PYTMYKVIJXPNBD-OQKDUQJOSA-N 0.000 description 1
- DKSKRBVXRDGYAS-UHFFFAOYSA-N 2-[4-[4-(butylcarbamoyl)-2-[(2,4-dichlorophenyl)sulfonylamino]phenoxy]-3-methoxyphenyl]acetic acid Chemical compound C=1C=C(Cl)C=C(Cl)C=1S(=O)(=O)NC1=CC(C(=O)NCCCC)=CC=C1OC1=CC=C(CC(O)=O)C=C1OC DKSKRBVXRDGYAS-UHFFFAOYSA-N 0.000 description 1
- PFWVGKROPKKEDW-UHFFFAOYSA-N 2-[4-[4-(tert-butylcarbamoyl)-2-[(2-chloro-4-cyclopropylphenyl)sulfonylamino]phenoxy]-5-chloro-2-fluorophenyl]acetic acid Chemical compound C=1C=C(C2CC2)C=C(Cl)C=1S(=O)(=O)NC1=CC(C(=O)NC(C)(C)C)=CC=C1OC1=CC(F)=C(CC(O)=O)C=C1Cl PFWVGKROPKKEDW-UHFFFAOYSA-N 0.000 description 1
- RTQWWZBSTRGEAV-PKHIMPSTSA-N 2-[[(2s)-2-[bis(carboxymethyl)amino]-3-[4-(methylcarbamoylamino)phenyl]propyl]-[2-[bis(carboxymethyl)amino]propyl]amino]acetic acid Chemical compound CNC(=O)NC1=CC=C(C[C@@H](CN(CC(C)N(CC(O)=O)CC(O)=O)CC(O)=O)N(CC(O)=O)CC(O)=O)C=C1 RTQWWZBSTRGEAV-PKHIMPSTSA-N 0.000 description 1
- FIEYHAAMDAPVCH-UHFFFAOYSA-N 2-methyl-1h-quinazolin-4-one Chemical compound C1=CC=C2NC(C)=NC(=O)C2=C1 FIEYHAAMDAPVCH-UHFFFAOYSA-N 0.000 description 1
- ZWTZHHHSRDUVRT-UHFFFAOYSA-N 2-methylsulfonylphenol Chemical compound CS(=O)(=O)C1=CC=CC=C1O ZWTZHHHSRDUVRT-UHFFFAOYSA-N 0.000 description 1
- 102100039463 2-oxoglutarate receptor 1 Human genes 0.000 description 1
- VRBFTYUMFJWSJY-UHFFFAOYSA-N 28804-46-8 Chemical compound ClC1CC(C=C2)=CC=C2C(Cl)CC2=CC=C1C=C2 VRBFTYUMFJWSJY-UHFFFAOYSA-N 0.000 description 1
- RBTBFTRPCNLSDE-UHFFFAOYSA-N 3,7-bis(dimethylamino)phenothiazin-5-ium Chemical compound C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 RBTBFTRPCNLSDE-UHFFFAOYSA-N 0.000 description 1
- PMXMIIMHBWHSKN-UHFFFAOYSA-N 3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one Chemical compound FC1=CC=C2C(C3CCN(CC3)CCC=3C(=O)N4CCCC(O)C4=NC=3C)=NOC2=C1 PMXMIIMHBWHSKN-UHFFFAOYSA-N 0.000 description 1
- 102000040125 5-hydroxytryptamine receptor family Human genes 0.000 description 1
- 108091032151 5-hydroxytryptamine receptor family Proteins 0.000 description 1
- DQOGWKZQQBYYMW-LQGIGNHCSA-N 5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline-2,4-diamine;(2s,3s,4s,5r,6s)-3,4,5,6-tetrahydroxyoxane-2-carboxylic acid Chemical compound O[C@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O.COC1=C(OC)C(OC)=CC(NCC=2C(=C3C(N)=NC(N)=NC3=CC=2)C)=C1 DQOGWKZQQBYYMW-LQGIGNHCSA-N 0.000 description 1
- VVIAGPKUTFNRDU-UHFFFAOYSA-N 6S-folinic acid Natural products C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-UHFFFAOYSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- CZTQZXZIADLWOZ-UHFFFAOYSA-O 8-oxo-3-(pyridin-1-ium-1-ylmethyl)-7-[(2-thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical compound C1SC2C(NC(=O)CC=3SC=CC=3)C(=O)N2C(C(=O)O)=C1C[N+]1=CC=CC=C1 CZTQZXZIADLWOZ-UHFFFAOYSA-O 0.000 description 1
- MKBLHFILKIKSQM-UHFFFAOYSA-N 9-methyl-3-[(2-methyl-1h-imidazol-3-ium-3-yl)methyl]-2,3-dihydro-1h-carbazol-4-one;chloride Chemical compound Cl.CC1=NC=CN1CC1C(=O)C(C=2C(=CC=CC=2)N2C)=C2CC1 MKBLHFILKIKSQM-UHFFFAOYSA-N 0.000 description 1
- 229940124965 ACAM2000 Drugs 0.000 description 1
- 108091005560 ADGRG3 Proteins 0.000 description 1
- 102100033793 ALK tyrosine kinase receptor Human genes 0.000 description 1
- 101710168331 ALK tyrosine kinase receptor Proteins 0.000 description 1
- 108010079335 AMG 745 Proteins 0.000 description 1
- 108010005042 AMG-220 Proteins 0.000 description 1
- 102100033350 ATP-dependent translocase ABCB1 Human genes 0.000 description 1
- 102100032792 ATPase family AAA domain-containing protein 2B Human genes 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- 229940124962 ActHIB Drugs 0.000 description 1
- 108010059616 Activins Proteins 0.000 description 1
- 102000005606 Activins Human genes 0.000 description 1
- 102000009346 Adenosine receptors Human genes 0.000 description 1
- 108050000203 Adenosine receptors Proteins 0.000 description 1
- 102100024437 Adhesion G protein-coupled receptor A1 Human genes 0.000 description 1
- 102100040037 Adhesion G protein-coupled receptor G3 Human genes 0.000 description 1
- 108060003345 Adrenergic Receptor Proteins 0.000 description 1
- 102000017910 Adrenergic receptor Human genes 0.000 description 1
- 239000000275 Adrenocorticotropic Hormone Substances 0.000 description 1
- 102100036601 Aggrecan core protein Human genes 0.000 description 1
- 229940124838 Agriflu Drugs 0.000 description 1
- 208000024827 Alzheimer disease Diseases 0.000 description 1
- 241001465677 Ancylostomatoidea Species 0.000 description 1
- 101710131689 Angiopoietin-1 receptor Proteins 0.000 description 1
- 102000008873 Angiotensin II receptor Human genes 0.000 description 1
- 108050000824 Angiotensin II receptor Proteins 0.000 description 1
- 102100039182 Ankyrin repeat and protein kinase domain-containing protein 1 Human genes 0.000 description 1
- WZPBZJONDBGPKJ-UHFFFAOYSA-N Antibiotic SQ 26917 Natural products O=C1N(S(O)(=O)=O)C(C)C1NC(=O)C(=NOC(C)(C)C(O)=O)C1=CSC(N)=N1 WZPBZJONDBGPKJ-UHFFFAOYSA-N 0.000 description 1
- 101100034357 Arabidopsis thaliana RIPK gene Proteins 0.000 description 1
- 208000006400 Arbovirus Encephalitis Diseases 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- GOLCXWYRSKYTSP-UHFFFAOYSA-N Arsenious Acid Chemical compound O1[As]2O[As]1O2 GOLCXWYRSKYTSP-UHFFFAOYSA-N 0.000 description 1
- QTGIAADRBBLJGA-UHFFFAOYSA-N Articaine Chemical compound CCCNC(C)C(=O)NC=1C(C)=CSC=1C(=O)OC QTGIAADRBBLJGA-UHFFFAOYSA-N 0.000 description 1
- 241000844174 Asclera Species 0.000 description 1
- 206010003594 Ataxia telangiectasia Diseases 0.000 description 1
- 102100035021 Ataxin-1-like Human genes 0.000 description 1
- 102100039339 Atrial natriuretic peptide receptor 1 Human genes 0.000 description 1
- 102100035952 Atypical kinase COQ8B, mitochondrial Human genes 0.000 description 1
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 description 1
- 241000193738 Bacillus anthracis Species 0.000 description 1
- KPYSYYIEGFHWSV-UHFFFAOYSA-N Baclofen Chemical compound OC(=O)CC(CN)C1=CC=C(Cl)C=C1 KPYSYYIEGFHWSV-UHFFFAOYSA-N 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 102100038495 Bile acid receptor Human genes 0.000 description 1
- 101710128505 Bile acid receptor Proteins 0.000 description 1
- 229940124899 Biothrax Drugs 0.000 description 1
- 108010073466 Bombesin Receptors Proteins 0.000 description 1
- 229940124900 Boostrix Drugs 0.000 description 1
- 102000010183 Bradykinin receptor Human genes 0.000 description 1
- 108050001736 Bradykinin receptor Proteins 0.000 description 1
- 108091005539 Brain-specific angiogenesis inhibitors Proteins 0.000 description 1
- 102100028243 Breast carcinoma-amplified sequence 1 Human genes 0.000 description 1
- 102100033641 Bromodomain-containing protein 2 Human genes 0.000 description 1
- 101710126816 Bromodomain-containing protein 2 Proteins 0.000 description 1
- 102100029897 Bromodomain-containing protein 7 Human genes 0.000 description 1
- 101710126818 Bromodomain-containing protein 7 Proteins 0.000 description 1
- 102300048873 Bromodomain-containing protein 9 isoform 1 Human genes 0.000 description 1
- 208000011691 Burkitt lymphomas Diseases 0.000 description 1
- NCBGHNOTSHZCAO-HTVVRFAVSA-N C(CC)O[C@@]1([C@H](O)[C@H](O)[C@@H](CO)O1)N1C=NC=2C(=O)NC(N)=NC1=2 Chemical compound C(CC)O[C@@]1([C@H](O)[C@H](O)[C@@H](CO)O1)N1C=NC=2C(=O)NC(N)=NC1=2 NCBGHNOTSHZCAO-HTVVRFAVSA-N 0.000 description 1
- 102100021390 C-terminal-binding protein 1 Human genes 0.000 description 1
- 101710178052 C-terminal-binding protein 1 Proteins 0.000 description 1
- 102100021703 C3a anaphylatoxin chemotactic receptor Human genes 0.000 description 1
- 102100032957 C5a anaphylatoxin chemotactic receptor 1 Human genes 0.000 description 1
- 108091008927 CC chemokine receptors Proteins 0.000 description 1
- 108091005932 CCKBR Proteins 0.000 description 1
- 102000005674 CCR Receptors Human genes 0.000 description 1
- 101150013553 CD40 gene Proteins 0.000 description 1
- 229940126609 CR6261 Drugs 0.000 description 1
- 101100004189 Caenorhabditis elegans brd-1 gene Proteins 0.000 description 1
- 101100273751 Caenorhabditis elegans cdc-42 gene Proteins 0.000 description 1
- 101100061460 Caenorhabditis elegans crtc-1 gene Proteins 0.000 description 1
- 101100182247 Caenorhabditis elegans lat-1 gene Proteins 0.000 description 1
- 101100133721 Caenorhabditis elegans npr-1 gene Proteins 0.000 description 1
- 108700010390 Calcitonin Receptor-Like Proteins 0.000 description 1
- 108010001789 Calcitonin Receptors Proteins 0.000 description 1
- 102100024654 Calcitonin gene-related peptide type 1 receptor Human genes 0.000 description 1
- 102100038520 Calcitonin receptor Human genes 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 102100038563 Calcium-binding mitochondrial carrier protein Aralar1 Human genes 0.000 description 1
- 108030005456 Calcium/calmodulin-dependent protein kinases Proteins 0.000 description 1
- 102000018208 Cannabinoid Receptor Human genes 0.000 description 1
- 108050007331 Cannabinoid receptor Proteins 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 108010031425 Casein Kinases Proteins 0.000 description 1
- 102000005403 Casein Kinases Human genes 0.000 description 1
- 102100035370 Cat eye syndrome critical region protein 2 Human genes 0.000 description 1
- 101710154939 Cat eye syndrome critical region protein 2 Proteins 0.000 description 1
- 102000011068 Cdc42 Human genes 0.000 description 1
- 102100025064 Cellular tumor antigen p53 Human genes 0.000 description 1
- 108700027941 Celsior Proteins 0.000 description 1
- 229940124957 Cervarix Drugs 0.000 description 1
- ZKLPARSLTMPFCP-UHFFFAOYSA-N Cetirizine Chemical compound C1CN(CCOCC(=O)O)CCN1C(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 ZKLPARSLTMPFCP-UHFFFAOYSA-N 0.000 description 1
- 108010019243 Checkpoint Kinase 2 Proteins 0.000 description 1
- 102100021198 Chemerin-like receptor 2 Human genes 0.000 description 1
- 102000009410 Chemokine receptor Human genes 0.000 description 1
- 108050000299 Chemokine receptor Proteins 0.000 description 1
- 102100030099 Chloride anion exchanger Human genes 0.000 description 1
- 108010089335 Cholecystokinin A Receptor Proteins 0.000 description 1
- 102000009660 Cholinergic Receptors Human genes 0.000 description 1
- 108010009685 Cholinergic Receptors Proteins 0.000 description 1
- 206010009344 Clonorchiasis Diseases 0.000 description 1
- 102100023804 Coagulation factor VII Human genes 0.000 description 1
- 229920002905 Colesevelam Polymers 0.000 description 1
- 102000004626 Colony-Stimulating Factor Receptors Human genes 0.000 description 1
- 108010003384 Colony-Stimulating Factor Receptors Proteins 0.000 description 1
- 102000007644 Colony-Stimulating Factors Human genes 0.000 description 1
- 108010071942 Colony-Stimulating Factors Proteins 0.000 description 1
- 229940124901 Comvax Drugs 0.000 description 1
- 208000034717 Congenital hereditary endothelial dystrophy type II Diseases 0.000 description 1
- 108010060123 Conjugate Vaccines Proteins 0.000 description 1
- 108010029704 Constitutive Androstane Receptor Proteins 0.000 description 1
- 208000015976 Corneal dystrophy-perceptive deafness syndrome Diseases 0.000 description 1
- 102400000739 Corticotropin Human genes 0.000 description 1
- 101800000414 Corticotropin Proteins 0.000 description 1
- 241000709687 Coxsackievirus Species 0.000 description 1
- 101100289206 Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) LIV4 gene Proteins 0.000 description 1
- 108010064003 Crystallins Proteins 0.000 description 1
- 102000014824 Crystallins Human genes 0.000 description 1
- 102000005636 Cyclic AMP Response Element-Binding Protein Human genes 0.000 description 1
- 108010045171 Cyclic AMP Response Element-Binding Protein Proteins 0.000 description 1
- 102000008130 Cyclic AMP-Dependent Protein Kinases Human genes 0.000 description 1
- 108010049894 Cyclic AMP-Dependent Protein Kinases Proteins 0.000 description 1
- 102000004654 Cyclic GMP-Dependent Protein Kinases Human genes 0.000 description 1
- 108010003591 Cyclic GMP-Dependent Protein Kinases Proteins 0.000 description 1
- 102000016736 Cyclin Human genes 0.000 description 1
- 108050006400 Cyclin Proteins 0.000 description 1
- 102000002431 Cyclin G Human genes 0.000 description 1
- 108090000404 Cyclin G1 Proteins 0.000 description 1
- 102100033539 Cysteinyl leukotriene receptor 2 Human genes 0.000 description 1
- 108090000655 Cysteinyl leukotriene receptor 2 Proteins 0.000 description 1
- 241000701022 Cytomegalovirus Species 0.000 description 1
- 101710197960 D-aminoacyl-tRNA deacylase Proteins 0.000 description 1
- 102100029010 D-aminoacyl-tRNA deacylase 1 Human genes 0.000 description 1
- 101710109959 D-aminoacyl-tRNA deacylase 1 Proteins 0.000 description 1
- XUIIKFGFIJCVMT-GFCCVEGCSA-N D-thyroxine Chemical compound IC1=CC(C[C@@H](N)C(O)=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-GFCCVEGCSA-N 0.000 description 1
- 229940124888 DECAVAC Drugs 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
- 230000012746 DNA damage checkpoint Effects 0.000 description 1
- 102100039116 DNA repair protein RAD50 Human genes 0.000 description 1
- 101710118395 DNA repair protein RAD50 Proteins 0.000 description 1
- 229940032024 DPT vaccine Drugs 0.000 description 1
- 101100009425 Danio rerio dexi gene Proteins 0.000 description 1
- 108010019673 Darbepoetin alfa Proteins 0.000 description 1
- 208000001490 Dengue Diseases 0.000 description 1
- 206010012310 Dengue fever Diseases 0.000 description 1
- 101001008993 Dictyostelium discoideum Kinesin-related protein 10 Proteins 0.000 description 1
- 101001050566 Dictyostelium discoideum Kinesin-related protein 2 Proteins 0.000 description 1
- 101001129314 Dictyostelium discoideum Probable plasma membrane ATPase Proteins 0.000 description 1
- 101000582926 Dictyostelium discoideum Probable serine/threonine-protein kinase PLK Proteins 0.000 description 1
- IJVCSMSMFSCRME-KBQPJGBKSA-N Dihydromorphine Chemical compound O([C@H]1[C@H](CC[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O IJVCSMSMFSCRME-KBQPJGBKSA-N 0.000 description 1
- 241001649081 Dina Species 0.000 description 1
- 108010043648 Discoidin Domain Receptors Proteins 0.000 description 1
- 102000002706 Discoidin Domain Receptors Human genes 0.000 description 1
- 101800001224 Disintegrin Proteins 0.000 description 1
- 102000015554 Dopamine receptor Human genes 0.000 description 1
- 108050004812 Dopamine receptor Proteins 0.000 description 1
- MWWSFMDVAYGXBV-RUELKSSGSA-N Doxorubicin hydrochloride Chemical compound Cl.O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 MWWSFMDVAYGXBV-RUELKSSGSA-N 0.000 description 1
- 101001004391 Drosophila melanogaster Protein jim lovell Proteins 0.000 description 1
- 101710108353 Dual specificity testis-specific protein kinase 1 Proteins 0.000 description 1
- 108010069091 Dystrophin Proteins 0.000 description 1
- 102000001039 Dystrophin Human genes 0.000 description 1
- 102100029505 E3 ubiquitin-protein ligase TRIM33 Human genes 0.000 description 1
- 101710164884 E3 ubiquitin-protein ligase TRIM33 Proteins 0.000 description 1
- 102000001301 EGF receptor Human genes 0.000 description 1
- 108060006698 EGF receptor Proteins 0.000 description 1
- 102000012545 EGF-like domains Human genes 0.000 description 1
- 108050002150 EGF-like domains Proteins 0.000 description 1
- 241000710945 Eastern equine encephalitis virus Species 0.000 description 1
- 229940124722 Ebola vaccine Drugs 0.000 description 1
- VWLHWLSRQJQWRG-UHFFFAOYSA-O Edrophonum Chemical compound CC[N+](C)(C)C1=CC=CC(O)=C1 VWLHWLSRQJQWRG-UHFFFAOYSA-O 0.000 description 1
- 102100021474 Electrogenic sodium bicarbonate cotransporter 1 Human genes 0.000 description 1
- 108010066671 Enalaprilat Proteins 0.000 description 1
- 206010052369 Encephalitis lethargica Diseases 0.000 description 1
- 102000010180 Endothelin receptor Human genes 0.000 description 1
- 108050001739 Endothelin receptor Proteins 0.000 description 1
- 241001529459 Enterovirus A71 Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 108091008815 Eph receptors Proteins 0.000 description 1
- 108010074604 Epoetin Alfa Proteins 0.000 description 1
- 102100021472 Equilibrative nucleoside transporter 3 Human genes 0.000 description 1
- 208000031637 Erythroblastic Acute Leukemia Diseases 0.000 description 1
- 208000036566 Erythroleukaemia Diseases 0.000 description 1
- 108090000394 Erythropoietin Proteins 0.000 description 1
- 102000003951 Erythropoietin Human genes 0.000 description 1
- 108090000371 Esterases Proteins 0.000 description 1
- 108010007005 Estrogen Receptor alpha Proteins 0.000 description 1
- IMROMDMJAWUWLK-UHFFFAOYSA-N Ethenol Chemical compound OC=C IMROMDMJAWUWLK-UHFFFAOYSA-N 0.000 description 1
- 229920000181 Ethylene propylene rubber Polymers 0.000 description 1
- 101710085809 Eukaryotic translation initiation factor 2-alpha kinase Proteins 0.000 description 1
- 102100034169 Eukaryotic translation initiation factor 2-alpha kinase 1 Human genes 0.000 description 1
- 101710196289 Eukaryotic translation initiation factor 2-alpha kinase 1 Proteins 0.000 description 1
- 101710196290 Eukaryotic translation initiation factor 2-alpha kinase 2 Proteins 0.000 description 1
- BPNZYADGDZPRTK-UDUYQYQQSA-N Exametazime Chemical compound O/N=C(\C)[C@@H](C)NCC(C)(C)CN[C@H](C)C(\C)=N\O BPNZYADGDZPRTK-UDUYQYQQSA-N 0.000 description 1
- 102100031563 Excitatory amino acid transporter 1 Human genes 0.000 description 1
- 108091008794 FGF receptors Proteins 0.000 description 1
- 108010014172 Factor V Proteins 0.000 description 1
- 108010023321 Factor VII Proteins 0.000 description 1
- 108010054218 Factor VIII Proteins 0.000 description 1
- 102000001690 Factor VIII Human genes 0.000 description 1
- 108010014173 Factor X Proteins 0.000 description 1
- 108010074864 Factor XI Proteins 0.000 description 1
- 108010071289 Factor XIII Proteins 0.000 description 1
- 102100039036 Feline leukemia virus subgroup C receptor-related protein 1 Human genes 0.000 description 1
- 102100035049 Feline leukemia virus subgroup C receptor-related protein 2 Human genes 0.000 description 1
- 241000282324 Felis Species 0.000 description 1
- 108010049003 Fibrinogen Proteins 0.000 description 1
- 102000008946 Fibrinogen Human genes 0.000 description 1
- 102000044168 Fibroblast Growth Factor Receptor Human genes 0.000 description 1
- 229940124895 FluMist Drugs 0.000 description 1
- 229940124947 FluMist Quadrivalent Drugs 0.000 description 1
- 229940124896 Fluarix Drugs 0.000 description 1
- 229940124945 Fluarix Quadrivalent Drugs 0.000 description 1
- 229940124943 Flublok Drugs 0.000 description 1
- 229940124893 Fluvirin Drugs 0.000 description 1
- 229940124906 Fluzone High-dose Drugs 0.000 description 1
- 229940124877 Fluzone intradermal Drugs 0.000 description 1
- 108010076288 Formyl peptide receptors Proteins 0.000 description 1
- 102000011652 Formyl peptide receptors Human genes 0.000 description 1
- 108070000009 Free fatty acid receptors Proteins 0.000 description 1
- 108091004242 G-Protein-Coupled Receptor Kinase 1 Proteins 0.000 description 1
- 102000004437 G-Protein-Coupled Receptor Kinase 1 Human genes 0.000 description 1
- 108010008959 G-Protein-Coupled Receptor Kinases Proteins 0.000 description 1
- 102000006575 G-Protein-Coupled Receptor Kinases Human genes 0.000 description 1
- 102100023328 G-protein coupled estrogen receptor 1 Human genes 0.000 description 1
- 102100033012 G-protein coupled receptor 12 Human genes 0.000 description 1
- 102100033837 G-protein coupled receptor 135 Human genes 0.000 description 1
- 102100039860 G-protein coupled receptor 143 Human genes 0.000 description 1
- 102100023416 G-protein coupled receptor 15 Human genes 0.000 description 1
- 102100041035 G-protein coupled receptor 151 Human genes 0.000 description 1
- 102100041016 G-protein coupled receptor 157 Human genes 0.000 description 1
- 102100025361 G-protein coupled receptor 161 Human genes 0.000 description 1
- 102100021200 G-protein coupled receptor 176 Human genes 0.000 description 1
- 102100021243 G-protein coupled receptor 182 Human genes 0.000 description 1
- 102100021245 G-protein coupled receptor 183 Human genes 0.000 description 1
- 101710101406 G-protein coupled receptor 183 Proteins 0.000 description 1
- 102100036939 G-protein coupled receptor 20 Human genes 0.000 description 1
- 102100036940 G-protein coupled receptor 22 Human genes 0.000 description 1
- 102100036931 G-protein coupled receptor 26 Human genes 0.000 description 1
- 102100033047 G-protein coupled receptor 3 Human genes 0.000 description 1
- 102100030279 G-protein coupled receptor 35 Human genes 0.000 description 1
- 102100031183 G-protein coupled receptor 37-like 1 Human genes 0.000 description 1
- 102100030280 G-protein coupled receptor 39 Human genes 0.000 description 1
- 102100033045 G-protein coupled receptor 4 Human genes 0.000 description 1
- 102100033046 G-protein coupled receptor 52 Human genes 0.000 description 1
- 102100033061 G-protein coupled receptor 55 Human genes 0.000 description 1
- 102100033861 G-protein coupled receptor 6 Human genes 0.000 description 1
- 102100033062 G-protein coupled receptor 61 Human genes 0.000 description 1
- 102100033859 G-protein coupled receptor 78 Human genes 0.000 description 1
- 102100033864 G-protein coupled receptor 84 Human genes 0.000 description 1
- 102100035226 GDP-fucose transporter 1 Human genes 0.000 description 1
- 102000001824 GPR146 Human genes 0.000 description 1
- 108050009062 GPR146 Proteins 0.000 description 1
- 101150023186 GRK1 gene Proteins 0.000 description 1
- 108091007911 GSKs Proteins 0.000 description 1
- 108010093031 Galactosidases Proteins 0.000 description 1
- 102000002464 Galactosidases Human genes 0.000 description 1
- 102000011392 Galanin receptor Human genes 0.000 description 1
- 108050001605 Galanin receptor Proteins 0.000 description 1
- 108010004460 Gastric Inhibitory Polypeptide Proteins 0.000 description 1
- 102100039994 Gastric inhibitory polypeptide Human genes 0.000 description 1
- 102100039997 Gastric inhibitory polypeptide receptor Human genes 0.000 description 1
- 102100036016 Gastrin/cholecystokinin type B receptor Human genes 0.000 description 1
- 229930182566 Gentamicin Natural products 0.000 description 1
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 1
- 208000010412 Glaucoma Diseases 0.000 description 1
- 108010063919 Glucagon Receptors Proteins 0.000 description 1
- 102100040890 Glucagon receptor Human genes 0.000 description 1
- 102000003676 Glucocorticoid Receptors Human genes 0.000 description 1
- 101710124882 Glucocorticoid receptor Proteins 0.000 description 1
- 102100039684 Glucose-6-phosphate exchanger SLC37A4 Human genes 0.000 description 1
- 102100033839 Glucose-dependent insulinotropic receptor Human genes 0.000 description 1
- 102000004103 Glycogen Synthase Kinases Human genes 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 244000060234 Gmelina philippensis Species 0.000 description 1
- 102000009465 Growth Factor Receptors Human genes 0.000 description 1
- 108010009202 Growth Factor Receptors Proteins 0.000 description 1
- 102000004858 Growth differentiation factor-9 Human genes 0.000 description 1
- 108090001086 Growth differentiation factor-9 Proteins 0.000 description 1
- 102100020948 Growth hormone receptor Human genes 0.000 description 1
- 102100030488 HEAT repeat-containing protein 6 Human genes 0.000 description 1
- 102000002812 Heat-Shock Proteins Human genes 0.000 description 1
- 108010004889 Heat-Shock Proteins Proteins 0.000 description 1
- 229940121827 Hedgehog pathway inhibitor Drugs 0.000 description 1
- 102000006752 Hepatocyte Nuclear Factor 4 Human genes 0.000 description 1
- 102100031000 Hepatoma-derived growth factor Human genes 0.000 description 1
- 201000003676 Hereditary hypophosphatemic rickets with hypercalciuria Diseases 0.000 description 1
- 208000007514 Herpes zoster Diseases 0.000 description 1
- 108700037566 Hib-MenCY-TT vaccine Proteins 0.000 description 1
- 229940124885 Hiberix Drugs 0.000 description 1
- 108700020122 Hiberix Proteins 0.000 description 1
- 102100027045 High affinity choline transporter 1 Human genes 0.000 description 1
- 102000000543 Histamine Receptors Human genes 0.000 description 1
- 108010002059 Histamine Receptors Proteins 0.000 description 1
- 102100034533 Histone H2AX Human genes 0.000 description 1
- 102100022901 Histone acetyltransferase KAT2A Human genes 0.000 description 1
- 101710083344 Histone acetyltransferase KAT2A Proteins 0.000 description 1
- 101710083341 Histone acetyltransferase KAT2B Proteins 0.000 description 1
- 102000009331 Homeodomain Proteins Human genes 0.000 description 1
- 108010048671 Homeodomain Proteins Proteins 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 101001071349 Homo sapiens 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor Proteins 0.000 description 1
- 101000609562 Homo sapiens 2-oxoglutarate receptor 1 Proteins 0.000 description 1
- 101000923353 Homo sapiens ATPase family AAA domain-containing protein 2B Proteins 0.000 description 1
- 101000833343 Homo sapiens Adhesion G protein-coupled receptor A1 Proteins 0.000 description 1
- 101000753291 Homo sapiens Angiopoietin-1 receptor Proteins 0.000 description 1
- 101000889403 Homo sapiens Ankyrin repeat and protein kinase domain-containing protein 1 Proteins 0.000 description 1
- 101000873101 Homo sapiens Ataxin-1-like Proteins 0.000 description 1
- 101000875775 Homo sapiens Atypical kinase COQ8B, mitochondrial Proteins 0.000 description 1
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 description 1
- 101000859448 Homo sapiens Beta/gamma crystallin domain-containing protein 1 Proteins 0.000 description 1
- 101000935635 Homo sapiens Breast carcinoma-amplified sequence 1 Proteins 0.000 description 1
- 101000896583 Homo sapiens C3a anaphylatoxin chemotactic receptor Proteins 0.000 description 1
- 101000867983 Homo sapiens C5a anaphylatoxin chemotactic receptor 1 Proteins 0.000 description 1
- 101000882698 Homo sapiens Calcium-binding mitochondrial carrier protein Aralar1 Proteins 0.000 description 1
- 101000710994 Homo sapiens Calcium-binding mitochondrial carrier protein Aralar2 Proteins 0.000 description 1
- 101000721661 Homo sapiens Cellular tumor antigen p53 Proteins 0.000 description 1
- 101000750094 Homo sapiens Chemerin-like receptor 2 Proteins 0.000 description 1
- 101000727806 Homo sapiens Chloride anion exchanger Proteins 0.000 description 1
- 101000777370 Homo sapiens Coiled-coil domain-containing protein 6 Proteins 0.000 description 1
- 101000864807 Homo sapiens Doublesex- and mab-3-related transcription factor 1 Proteins 0.000 description 1
- 101000822041 Homo sapiens Equilibrative nucleoside transporter 3 Proteins 0.000 description 1
- 101000866286 Homo sapiens Excitatory amino acid transporter 1 Proteins 0.000 description 1
- 101001029786 Homo sapiens Feline leukemia virus subgroup C receptor-related protein 1 Proteins 0.000 description 1
- 101001022717 Homo sapiens Feline leukemia virus subgroup C receptor-related protein 2 Proteins 0.000 description 1
- 101000829902 Homo sapiens G-protein coupled estrogen receptor 1 Proteins 0.000 description 1
- 101001015106 Homo sapiens G-protein coupled receptor 12 Proteins 0.000 description 1
- 101000996783 Homo sapiens G-protein coupled receptor 135 Proteins 0.000 description 1
- 101000887425 Homo sapiens G-protein coupled receptor 143 Proteins 0.000 description 1
- 101000829794 Homo sapiens G-protein coupled receptor 15 Proteins 0.000 description 1
- 101001039308 Homo sapiens G-protein coupled receptor 151 Proteins 0.000 description 1
- 101001039303 Homo sapiens G-protein coupled receptor 157 Proteins 0.000 description 1
- 101000857756 Homo sapiens G-protein coupled receptor 161 Proteins 0.000 description 1
- 101001040723 Homo sapiens G-protein coupled receptor 176 Proteins 0.000 description 1
- 101001040797 Homo sapiens G-protein coupled receptor 182 Proteins 0.000 description 1
- 101001071355 Homo sapiens G-protein coupled receptor 20 Proteins 0.000 description 1
- 101001071360 Homo sapiens G-protein coupled receptor 22 Proteins 0.000 description 1
- 101001071346 Homo sapiens G-protein coupled receptor 26 Proteins 0.000 description 1
- 101000871088 Homo sapiens G-protein coupled receptor 3 Proteins 0.000 description 1
- 101001009545 Homo sapiens G-protein coupled receptor 35 Proteins 0.000 description 1
- 101001066101 Homo sapiens G-protein coupled receptor 37-like 1 Proteins 0.000 description 1
- 101001009541 Homo sapiens G-protein coupled receptor 39 Proteins 0.000 description 1
- 101000871138 Homo sapiens G-protein coupled receptor 4 Proteins 0.000 description 1
- 101000871149 Homo sapiens G-protein coupled receptor 52 Proteins 0.000 description 1
- 101000871151 Homo sapiens G-protein coupled receptor 55 Proteins 0.000 description 1
- 101001069613 Homo sapiens G-protein coupled receptor 6 Proteins 0.000 description 1
- 101000871155 Homo sapiens G-protein coupled receptor 61 Proteins 0.000 description 1
- 101001069603 Homo sapiens G-protein coupled receptor 78 Proteins 0.000 description 1
- 101001069589 Homo sapiens G-protein coupled receptor 84 Proteins 0.000 description 1
- 101001022159 Homo sapiens GDP-fucose transporter 1 Proteins 0.000 description 1
- 101000886173 Homo sapiens Glucose-6-phosphate exchanger SLC37A4 Proteins 0.000 description 1
- 101000996752 Homo sapiens Glucose-dependent insulinotropic receptor Proteins 0.000 description 1
- 101000990566 Homo sapiens HEAT repeat-containing protein 6 Proteins 0.000 description 1
- 101000972946 Homo sapiens Hepatocyte growth factor receptor Proteins 0.000 description 1
- 101000693882 Homo sapiens High affinity choline transporter 1 Proteins 0.000 description 1
- 101001067891 Homo sapiens Histone H2AX Proteins 0.000 description 1
- 101001047006 Homo sapiens Histone acetyltransferase KAT2B Proteins 0.000 description 1
- 101000976075 Homo sapiens Insulin Proteins 0.000 description 1
- 101000599951 Homo sapiens Insulin-like growth factor I Proteins 0.000 description 1
- 101000926535 Homo sapiens Interferon-induced, double-stranded RNA-activated protein kinase Proteins 0.000 description 1
- 101000685660 Homo sapiens Long-chain fatty acid transport protein 4 Proteins 0.000 description 1
- 101001106413 Homo sapiens Macrophage-stimulating protein receptor Proteins 0.000 description 1
- 101000937642 Homo sapiens Malonyl-CoA-acyl carrier protein transacylase, mitochondrial Proteins 0.000 description 1
- 101000581402 Homo sapiens Melanin-concentrating hormone receptor 1 Proteins 0.000 description 1
- 101001116388 Homo sapiens Melatonin-related receptor Proteins 0.000 description 1
- 101000687968 Homo sapiens Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase Proteins 0.000 description 1
- 101000957437 Homo sapiens Mitochondrial carnitine/acylcarnitine carrier protein Proteins 0.000 description 1
- 101001038443 Homo sapiens Mitochondrial glutamate carrier 1 Proteins 0.000 description 1
- 101000590830 Homo sapiens Monocarboxylate transporter 1 Proteins 0.000 description 1
- 101000969630 Homo sapiens Monocarboxylate transporter 10 Proteins 0.000 description 1
- 101000969621 Homo sapiens Monocarboxylate transporter 12 Proteins 0.000 description 1
- 101000987117 Homo sapiens Monocarboxylate transporter 8 Proteins 0.000 description 1
- 101000829761 Homo sapiens N-arachidonyl glycine receptor Proteins 0.000 description 1
- 101000973618 Homo sapiens NF-kappa-B essential modulator Proteins 0.000 description 1
- 101000961071 Homo sapiens NF-kappa-B inhibitor alpha Proteins 0.000 description 1
- 101001125327 Homo sapiens Na(+)/H(+) exchange regulatory cofactor NHE-RF1 Proteins 0.000 description 1
- 101001108330 Homo sapiens Natural resistance-associated macrophage protein 2 Proteins 0.000 description 1
- 101000577224 Homo sapiens Neuropeptide S receptor Proteins 0.000 description 1
- 101000591385 Homo sapiens Neurotensin receptor type 1 Proteins 0.000 description 1
- 101001120760 Homo sapiens Olfactomedin-4 Proteins 0.000 description 1
- 101100244966 Homo sapiens PRKX gene Proteins 0.000 description 1
- 101001028756 Homo sapiens Phosphate carrier protein, mitochondrial Proteins 0.000 description 1
- 101000801684 Homo sapiens Phospholipid-transporting ATPase ABCA1 Proteins 0.000 description 1
- 101000735539 Homo sapiens Pituitary adenylate cyclase-activating polypeptide Proteins 0.000 description 1
- 101001081555 Homo sapiens Plasma protease C1 inhibitor Proteins 0.000 description 1
- 101001070479 Homo sapiens Probable G-protein coupled receptor 101 Proteins 0.000 description 1
- 101000996785 Homo sapiens Probable G-protein coupled receptor 132 Proteins 0.000 description 1
- 101000996780 Homo sapiens Probable G-protein coupled receptor 139 Proteins 0.000 description 1
- 101000887420 Homo sapiens Probable G-protein coupled receptor 141 Proteins 0.000 description 1
- 101000887427 Homo sapiens Probable G-protein coupled receptor 142 Proteins 0.000 description 1
- 101000887485 Homo sapiens Probable G-protein coupled receptor 148 Proteins 0.000 description 1
- 101000887481 Homo sapiens Probable G-protein coupled receptor 149 Proteins 0.000 description 1
- 101000887486 Homo sapiens Probable G-protein coupled receptor 150 Proteins 0.000 description 1
- 101001039294 Homo sapiens Probable G-protein coupled receptor 152 Proteins 0.000 description 1
- 101000857759 Homo sapiens Probable G-protein coupled receptor 162 Proteins 0.000 description 1
- 101001014654 Homo sapiens Probable G-protein coupled receptor 171 Proteins 0.000 description 1
- 101001014640 Homo sapiens Probable G-protein coupled receptor 173 Proteins 0.000 description 1
- 101001071348 Homo sapiens Probable G-protein coupled receptor 25 Proteins 0.000 description 1
- 101001071353 Homo sapiens Probable G-protein coupled receptor 27 Proteins 0.000 description 1
- 101001009517 Homo sapiens Probable G-protein coupled receptor 32 Proteins 0.000 description 1
- 101000871096 Homo sapiens Probable G-protein coupled receptor 45 Proteins 0.000 description 1
- 101001069607 Homo sapiens Probable G-protein coupled receptor 75 Proteins 0.000 description 1
- 101001069595 Homo sapiens Probable G-protein coupled receptor 83 Proteins 0.000 description 1
- 101001069583 Homo sapiens Probable G-protein coupled receptor 85 Proteins 0.000 description 1
- 101001033058 Homo sapiens Probable G-protein coupled receptor 88 Proteins 0.000 description 1
- 101001070474 Homo sapiens Protein GPR107 Proteins 0.000 description 1
- 101000579716 Homo sapiens Protein RFT1 homolog Proteins 0.000 description 1
- 101001098529 Homo sapiens Proteinase-activated receptor 1 Proteins 0.000 description 1
- 101000713293 Homo sapiens Proton-coupled amino acid transporter 2 Proteins 0.000 description 1
- 101001116987 Homo sapiens Proton-coupled folate transporter Proteins 0.000 description 1
- 101000738506 Homo sapiens Psychosine receptor Proteins 0.000 description 1
- 101100094910 Homo sapiens SLC52A2 gene Proteins 0.000 description 1
- 101000984753 Homo sapiens Serine/threonine-protein kinase B-raf Proteins 0.000 description 1
- 101000777293 Homo sapiens Serine/threonine-protein kinase Chk1 Proteins 0.000 description 1
- 101000777277 Homo sapiens Serine/threonine-protein kinase Chk2 Proteins 0.000 description 1
- 101000577652 Homo sapiens Serine/threonine-protein kinase PRP4 homolog Proteins 0.000 description 1
- 101000864800 Homo sapiens Serine/threonine-protein kinase Sgk1 Proteins 0.000 description 1
- 101000989953 Homo sapiens Serine/threonine-protein kinase haspin Proteins 0.000 description 1
- 101001001648 Homo sapiens Serine/threonine-protein kinase pim-2 Proteins 0.000 description 1
- 101001001645 Homo sapiens Serine/threonine-protein kinase pim-3 Proteins 0.000 description 1
- 101000685690 Homo sapiens Sialin Proteins 0.000 description 1
- 101000688930 Homo sapiens Signaling threshold-regulating transmembrane adapter 1 Proteins 0.000 description 1
- 101000684919 Homo sapiens Sodium- and chloride-dependent creatine transporter 1 Proteins 0.000 description 1
- 101000821903 Homo sapiens Solute carrier family 22 member 12 Proteins 0.000 description 1
- 101000908580 Homo sapiens Spliceosome RNA helicase DDX39B Proteins 0.000 description 1
- 101000716102 Homo sapiens T-cell surface glycoprotein CD4 Proteins 0.000 description 1
- 101000889890 Homo sapiens Testis-expressed protein 11 Proteins 0.000 description 1
- 101000727772 Homo sapiens Thiamine transporter 1 Proteins 0.000 description 1
- 101000891649 Homo sapiens Transcription elongation factor A protein-like 1 Proteins 0.000 description 1
- 101000823316 Homo sapiens Tyrosine-protein kinase ABL1 Proteins 0.000 description 1
- 101000606129 Homo sapiens Tyrosine-protein kinase receptor TYRO3 Proteins 0.000 description 1
- 101000672037 Homo sapiens UDP-glucose:glycoprotein glucosyltransferase 2 Proteins 0.000 description 1
- 101000829770 Homo sapiens Uracil nucleotide/cysteinyl leukotriene receptor Proteins 0.000 description 1
- 101000621390 Homo sapiens Wee1-like protein kinase Proteins 0.000 description 1
- 101000869416 Homo sapiens Zinc transporter ZIP13 Proteins 0.000 description 1
- 101000685830 Homo sapiens Zinc transporter ZIP4 Proteins 0.000 description 1
- 102000013266 Human Regular Insulin Human genes 0.000 description 1
- 108010090613 Human Regular Insulin Proteins 0.000 description 1
- 241000405425 Hura Species 0.000 description 1
- 108010003272 Hyaluronate lyase Proteins 0.000 description 1
- 102000001974 Hyaluronidases Human genes 0.000 description 1
- 241000257303 Hymenoptera Species 0.000 description 1
- 108010000178 IGF-I-IGFBP-3 complex Proteins 0.000 description 1
- 229940124913 IPOL Drugs 0.000 description 1
- 102100021711 Ileal sodium/bile acid cotransporter Human genes 0.000 description 1
- 102000016844 Immunoglobulin-like domains Human genes 0.000 description 1
- 108050006430 Immunoglobulin-like domains Proteins 0.000 description 1
- 101000668058 Infectious salmon anemia virus (isolate Atlantic salmon/Norway/810/9/99) RNA-directed RNA polymerase catalytic subunit Proteins 0.000 description 1
- 102000002746 Inhibins Human genes 0.000 description 1
- 108010004250 Inhibins Proteins 0.000 description 1
- 108010089308 Insulin Detemir Proteins 0.000 description 1
- 108010065920 Insulin Lispro Proteins 0.000 description 1
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 1
- 102000014429 Insulin-like growth factor Human genes 0.000 description 1
- 102100039688 Insulin-like growth factor 1 receptor Human genes 0.000 description 1
- 101710184277 Insulin-like growth factor 1 receptor Proteins 0.000 description 1
- 102100037852 Insulin-like growth factor I Human genes 0.000 description 1
- 101710089751 Interferon-induced, double-stranded RNA-activated protein kinase Proteins 0.000 description 1
- 108010050904 Interferons Proteins 0.000 description 1
- 102000014150 Interferons Human genes 0.000 description 1
- 102000045959 Interleukin-1 Receptor-Like 1 Human genes 0.000 description 1
- 108700003107 Interleukin-1 Receptor-Like 1 Proteins 0.000 description 1
- 102000003816 Interleukin-13 Human genes 0.000 description 1
- 108090000176 Interleukin-13 Proteins 0.000 description 1
- 102000015696 Interleukins Human genes 0.000 description 1
- 108010063738 Interleukins Proteins 0.000 description 1
- 102000004310 Ion Channels Human genes 0.000 description 1
- 108090000862 Ion Channels Proteins 0.000 description 1
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 1
- PWWVAXIEGOYWEE-UHFFFAOYSA-N Isophenergan Chemical compound C1=CC=C2N(CC(C)N(C)C)C3=CC=CC=C3SC2=C1 PWWVAXIEGOYWEE-UHFFFAOYSA-N 0.000 description 1
- 229940124956 Ixiaro Drugs 0.000 description 1
- 229940124918 JE-Vax Drugs 0.000 description 1
- 108010024121 Janus Kinases Proteins 0.000 description 1
- 102000015617 Janus Kinases Human genes 0.000 description 1
- 229940124919 Kinrix Drugs 0.000 description 1
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- XNSAINXGIQZQOO-UHFFFAOYSA-N L-pyroglutamyl-L-histidyl-L-proline amide Natural products NC(=O)C1CCCN1C(=O)C(NC(=O)C1NC(=O)CC1)CC1=CN=CN1 XNSAINXGIQZQOO-UHFFFAOYSA-N 0.000 description 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 1
- XUIIKFGFIJCVMT-LBPRGKRZSA-N L-thyroxine Chemical compound IC1=CC(C[C@H]([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-LBPRGKRZSA-N 0.000 description 1
- 239000005551 L01XE03 - Erlotinib Substances 0.000 description 1
- 102000008238 LHRH Receptors Human genes 0.000 description 1
- 108010021290 LHRH Receptors Proteins 0.000 description 1
- 206010024229 Leprosy Diseases 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- 108010006444 Leucine-Rich Repeat Proteins Proteins 0.000 description 1
- 208000030514 Leukocyte adhesion deficiency type II Diseases 0.000 description 1
- 108090000093 Leukotriene B4 receptors Proteins 0.000 description 1
- 241000975635 Lexias Species 0.000 description 1
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 1
- YEJCDKJIEMIWRQ-UHFFFAOYSA-N Linopirdine Chemical compound O=C1N(C=2C=CC=CC=2)C2=CC=CC=C2C1(CC=1C=CN=CC=1)CC1=CC=NC=C1 YEJCDKJIEMIWRQ-UHFFFAOYSA-N 0.000 description 1
- 229930184725 Lipoxin Natural products 0.000 description 1
- 102100023113 Long-chain fatty acid transport protein 4 Human genes 0.000 description 1
- 241000023320 Luma <angiosperm> Species 0.000 description 1
- 108010073521 Luteinizing Hormone Proteins 0.000 description 1
- 102000009151 Luteinizing Hormone Human genes 0.000 description 1
- 208000028018 Lymphocytic leukaemia Diseases 0.000 description 1
- 108010074338 Lymphokines Proteins 0.000 description 1
- 102000008072 Lymphokines Human genes 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 102000004137 Lysophosphatidic Acid Receptors Human genes 0.000 description 1
- 108090000642 Lysophosphatidic Acid Receptors Proteins 0.000 description 1
- 102100021435 Macrophage-stimulating protein receptor Human genes 0.000 description 1
- 102100024295 Maltase-glucoamylase Human genes 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 241001115401 Marburgvirus Species 0.000 description 1
- 102400001132 Melanin-concentrating hormone Human genes 0.000 description 1
- 101800002739 Melanin-concentrating hormone Proteins 0.000 description 1
- 102100027375 Melanin-concentrating hormone receptor 1 Human genes 0.000 description 1
- 102000004378 Melanocortin Receptors Human genes 0.000 description 1
- 108090000950 Melanocortin Receptors Proteins 0.000 description 1
- 101710151321 Melanostatin Proteins 0.000 description 1
- YJPIGAIKUZMOQA-UHFFFAOYSA-N Melatonin Natural products COC1=CC=C2N(C(C)=O)C=C(CCN)C2=C1 YJPIGAIKUZMOQA-UHFFFAOYSA-N 0.000 description 1
- 102000001419 Melatonin receptor Human genes 0.000 description 1
- 108050009605 Melatonin receptor Proteins 0.000 description 1
- 102100024972 Melatonin-related receptor Human genes 0.000 description 1
- 244000062730 Melissa officinalis Species 0.000 description 1
- 235000010654 Melissa officinalis Nutrition 0.000 description 1
- 108010034263 Member 1 Group A Nuclear Receptor Subfamily 6 Proteins 0.000 description 1
- 108010047230 Member 1 Subfamily B ATP Binding Cassette Transporter Proteins 0.000 description 1
- 102000018697 Membrane Proteins Human genes 0.000 description 1
- 102000003939 Membrane transport proteins Human genes 0.000 description 1
- 102100024262 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase Human genes 0.000 description 1
- 229940124887 MenHibrix Drugs 0.000 description 1
- 229940124904 Menactra Drugs 0.000 description 1
- 241001072983 Mentha Species 0.000 description 1
- 235000014435 Mentha Nutrition 0.000 description 1
- 229940124951 Menveo Drugs 0.000 description 1
- 108010006035 Metalloproteases Proteins 0.000 description 1
- 102000005741 Metalloproteases Human genes 0.000 description 1
- 108010020004 Microtubule-Associated Proteins Proteins 0.000 description 1
- 102000009664 Microtubule-Associated Proteins Human genes 0.000 description 1
- 108090000375 Mineralocorticoid Receptors Proteins 0.000 description 1
- 101710084732 Mineralocorticoid receptor Proteins 0.000 description 1
- 102100038738 Mitochondrial carnitine/acylcarnitine carrier protein Human genes 0.000 description 1
- 102100040273 Mitochondrial glutamate carrier 1 Human genes 0.000 description 1
- 102100030177 Mixed lineage kinase domain-like protein Human genes 0.000 description 1
- 101710083978 Mixed lineage kinase domain-like protein Proteins 0.000 description 1
- 241000713862 Moloney murine sarcoma virus Species 0.000 description 1
- 102100034068 Monocarboxylate transporter 1 Human genes 0.000 description 1
- 102100021425 Monocarboxylate transporter 10 Human genes 0.000 description 1
- 102100021444 Monocarboxylate transporter 12 Human genes 0.000 description 1
- 102100027871 Monocarboxylate transporter 8 Human genes 0.000 description 1
- 102000013967 Monokines Human genes 0.000 description 1
- 108010050619 Monokines Proteins 0.000 description 1
- 102000057413 Motilin receptors Human genes 0.000 description 1
- 108700040483 Motilin receptors Proteins 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 101000896532 Mus musculus C3a anaphylatoxin chemotactic receptor Proteins 0.000 description 1
- 101100009427 Mus musculus Dexi gene Proteins 0.000 description 1
- 101100448240 Mus musculus Gdf9 gene Proteins 0.000 description 1
- 101100297651 Mus musculus Pim2 gene Proteins 0.000 description 1
- 101100091501 Mus musculus Ros1 gene Proteins 0.000 description 1
- 101100187409 Mus musculus Slc34a2 gene Proteins 0.000 description 1
- 102000014415 Muscarinic acetylcholine receptor Human genes 0.000 description 1
- 108050003473 Muscarinic acetylcholine receptor Proteins 0.000 description 1
- 102100023414 N-arachidonyl glycine receptor Human genes 0.000 description 1
- 101710095135 NAD(P)H dehydrogenase [quinone] 1 Proteins 0.000 description 1
- 108010071382 NF-E2-Related Factor 2 Proteins 0.000 description 1
- 102100022219 NF-kappa-B essential modulator Human genes 0.000 description 1
- 102100039337 NF-kappa-B inhibitor alpha Human genes 0.000 description 1
- 102100029447 Na(+)/H(+) exchange regulatory cofactor NHE-RF1 Human genes 0.000 description 1
- JKWKMORAXJQQSR-MOPIKTETSA-N Nandrolone Decanoate Chemical compound C1CC2=CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CC[C@H](OC(=O)CCCCCCCCC)[C@@]1(C)CC2 JKWKMORAXJQQSR-MOPIKTETSA-N 0.000 description 1
- 241000737052 Naso hexacanthus Species 0.000 description 1
- 102400001270 Neuronostatin Human genes 0.000 description 1
- 102000011783 Neuropeptide B/W receptor Human genes 0.000 description 1
- 108050002200 Neuropeptide B/W receptor Proteins 0.000 description 1
- 102400001095 Neuropeptide FF Human genes 0.000 description 1
- 102100029049 Neuropeptide FF receptor 1 Human genes 0.000 description 1
- 101710105949 Neuropeptide FF receptor 1 Proteins 0.000 description 1
- 102100025258 Neuropeptide S receptor Human genes 0.000 description 1
- 102400000064 Neuropeptide Y Human genes 0.000 description 1
- 108050002826 Neuropeptide Y Receptor Proteins 0.000 description 1
- 102000012301 Neuropeptide Y receptor Human genes 0.000 description 1
- 102000009497 Neuropeptide Y1 receptors Human genes 0.000 description 1
- 108050000303 Neuropeptide Y1 receptors Proteins 0.000 description 1
- 102000029748 Neuropeptide Y2 receptor Human genes 0.000 description 1
- 108090000772 Neuropilin-1 Proteins 0.000 description 1
- 101100187130 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) nim-1 gene Proteins 0.000 description 1
- 102100033986 Neurotensin receptor type 1 Human genes 0.000 description 1
- 102100024403 Nibrin Human genes 0.000 description 1
- 108050003990 Nibrin Proteins 0.000 description 1
- 102100032028 Non-receptor tyrosine-protein kinase TYK2 Human genes 0.000 description 1
- 208000031662 Noncommunicable disease Diseases 0.000 description 1
- 241001263478 Norovirus Species 0.000 description 1
- 102100031701 Nuclear factor erythroid 2-related factor 2 Human genes 0.000 description 1
- 102100038494 Nuclear receptor subfamily 1 group I member 2 Human genes 0.000 description 1
- 102100038512 Nuclear receptor subfamily 1 group I member 3 Human genes 0.000 description 1
- 102100022670 Nuclear receptor subfamily 6 group A member 1 Human genes 0.000 description 1
- 102300044287 Nucleosome-remodeling factor subunit BPTF isoform 1 Human genes 0.000 description 1
- 108010042215 OX40 Ligand Proteins 0.000 description 1
- 102000004473 OX40 Ligand Human genes 0.000 description 1
- 208000022873 Ocular disease Diseases 0.000 description 1
- 241000243985 Onchocerca volvulus Species 0.000 description 1
- 108010053291 Oncogene Protein v-akt Proteins 0.000 description 1
- 108010062618 Oncogene Proteins v-rel Proteins 0.000 description 1
- 102000003840 Opioid Receptors Human genes 0.000 description 1
- 108090000137 Opioid Receptors Proteins 0.000 description 1
- 102100032646 Opsin-5 Human genes 0.000 description 1
- 101710131039 Opsin-5 Proteins 0.000 description 1
- 108050000742 Orexin Receptor Proteins 0.000 description 1
- 102000008834 Orexin receptor Human genes 0.000 description 1
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 description 1
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 description 1
- 102000016978 Orphan receptors Human genes 0.000 description 1
- 108070000031 Orphan receptors Proteins 0.000 description 1
- 206010033128 Ovarian cancer Diseases 0.000 description 1
- 206010061535 Ovarian neoplasm Diseases 0.000 description 1
- 102100038476 Oxysterols receptor LXR-alpha Human genes 0.000 description 1
- 101710111784 Oxysterols receptor LXR-alpha Proteins 0.000 description 1
- 102100038477 Oxysterols receptor LXR-beta Human genes 0.000 description 1
- 101710196648 Oxysterols receptor LXR-beta Proteins 0.000 description 1
- 239000012661 PARP inhibitor Substances 0.000 description 1
- 102000002131 PAS domains Human genes 0.000 description 1
- 108050009469 PAS domains Proteins 0.000 description 1
- 108091008606 PDGF receptors Proteins 0.000 description 1
- 241001536563 Panus Species 0.000 description 1
- 101000713179 Papio hamadryas Solute carrier family 52, riboflavin transporter, member 2 Proteins 0.000 description 1
- 208000030852 Parasitic disease Diseases 0.000 description 1
- 108010058828 Parathyroid Hormone Receptors Proteins 0.000 description 1
- 102000006461 Parathyroid Hormone Receptors Human genes 0.000 description 1
- 108090000445 Parathyroid hormone Proteins 0.000 description 1
- 102000003982 Parathyroid hormone Human genes 0.000 description 1
- 229940124909 PedvaxHIB Drugs 0.000 description 1
- 101800005149 Peptide B Proteins 0.000 description 1
- 102000015731 Peptide Hormones Human genes 0.000 description 1
- 108010038988 Peptide Hormones Proteins 0.000 description 1
- 102100037170 Phosphate carrier protein, mitochondrial Human genes 0.000 description 1
- 108700019535 Phosphoprotein Phosphatases Proteins 0.000 description 1
- 102000045595 Phosphoprotein Phosphatases Human genes 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 102100035733 Pituitary adenylate cyclase-activating polypeptide Human genes 0.000 description 1
- 102100027637 Plasma protease C1 inhibitor Human genes 0.000 description 1
- 102000011653 Platelet-Derived Growth Factor Receptors Human genes 0.000 description 1
- 108700023400 Platelet-activating factor receptors Proteins 0.000 description 1
- 229920001363 Polidocanol Polymers 0.000 description 1
- 229940121906 Poly ADP ribose polymerase inhibitor Drugs 0.000 description 1
- 239000005062 Polybutadiene Substances 0.000 description 1
- 239000004695 Polyether sulfone Substances 0.000 description 1
- 239000004642 Polyimide Substances 0.000 description 1
- 108010001511 Pregnane X Receptor Proteins 0.000 description 1
- 102100035276 Prestin Human genes 0.000 description 1
- 108050001617 Prestin Proteins 0.000 description 1
- 229940124876 ProQuad Drugs 0.000 description 1
- 102100034137 Probable G-protein coupled receptor 101 Human genes 0.000 description 1
- 102100033838 Probable G-protein coupled receptor 132 Human genes 0.000 description 1
- 102100033836 Probable G-protein coupled receptor 139 Human genes 0.000 description 1
- 102100039863 Probable G-protein coupled receptor 141 Human genes 0.000 description 1
- 102100039861 Probable G-protein coupled receptor 142 Human genes 0.000 description 1
- 102100039878 Probable G-protein coupled receptor 148 Human genes 0.000 description 1
- 102100039859 Probable G-protein coupled receptor 149 Human genes 0.000 description 1
- 102100039876 Probable G-protein coupled receptor 150 Human genes 0.000 description 1
- 102100041020 Probable G-protein coupled receptor 152 Human genes 0.000 description 1
- 102100025358 Probable G-protein coupled receptor 162 Human genes 0.000 description 1
- 102100032555 Probable G-protein coupled receptor 171 Human genes 0.000 description 1
- 102100032561 Probable G-protein coupled receptor 173 Human genes 0.000 description 1
- 102100036932 Probable G-protein coupled receptor 25 Human genes 0.000 description 1
- 102100036938 Probable G-protein coupled receptor 27 Human genes 0.000 description 1
- 102100030321 Probable G-protein coupled receptor 32 Human genes 0.000 description 1
- 102100033048 Probable G-protein coupled receptor 45 Human genes 0.000 description 1
- 102100033860 Probable G-protein coupled receptor 75 Human genes 0.000 description 1
- 102100033865 Probable G-protein coupled receptor 83 Human genes 0.000 description 1
- 102100033863 Probable G-protein coupled receptor 85 Human genes 0.000 description 1
- 102100038404 Probable G-protein coupled receptor 88 Human genes 0.000 description 1
- 108050000258 Prostaglandin D receptors Proteins 0.000 description 1
- 102100024212 Prostaglandin D2 receptor Human genes 0.000 description 1
- 102000008866 Prostaglandin E receptors Human genes 0.000 description 1
- 108010088540 Prostaglandin E receptors Proteins 0.000 description 1
- 102000000471 Prostaglandin F receptors Human genes 0.000 description 1
- 108050008995 Prostaglandin F receptors Proteins 0.000 description 1
- 101800001072 Protein 1A Proteins 0.000 description 1
- 101800004937 Protein C Proteins 0.000 description 1
- 102100034143 Protein GPR107 Human genes 0.000 description 1
- 108091008611 Protein Kinase B Proteins 0.000 description 1
- 108090000315 Protein Kinase C Proteins 0.000 description 1
- 102000003923 Protein Kinase C Human genes 0.000 description 1
- 102100034603 Protein arginine N-methyltransferase 3 Human genes 0.000 description 1
- 101710084424 Protein arginine N-methyltransferase 3 Proteins 0.000 description 1
- 102100035697 Protein kinase C-binding protein 1 Human genes 0.000 description 1
- 101710155341 Protein kinase C-binding protein 1 Proteins 0.000 description 1
- 102100023068 Protein kinase C-binding protein NELL1 Human genes 0.000 description 1
- 101710094328 Protein-tyrosine kinase 6 Proteins 0.000 description 1
- 102100037136 Proteinase-activated receptor 1 Human genes 0.000 description 1
- 108010094028 Prothrombin Proteins 0.000 description 1
- 102100027378 Prothrombin Human genes 0.000 description 1
- 102000005765 Proto-Oncogene Proteins c-akt Human genes 0.000 description 1
- 108010089836 Proto-Oncogene Proteins c-met Proteins 0.000 description 1
- 102100023347 Proto-oncogene tyrosine-protein kinase ROS Human genes 0.000 description 1
- 102100036919 Proton-coupled amino acid transporter 2 Human genes 0.000 description 1
- 102100024267 Proton-coupled folate transporter Human genes 0.000 description 1
- GTRPODKMSBFDOI-UHFFFAOYSA-N Protopine Natural products CN1Cc2c3OCOc3ccc2C4C1Cc5cc6OCOc6cc5C4=O GTRPODKMSBFDOI-UHFFFAOYSA-N 0.000 description 1
- ZAALQOFZFANFTF-UHFFFAOYSA-N Pseudoprotipine Natural products C1=C2C(=O)CC3=CC=4OCOC=4C=C3CN(C)CCC2=CC2=C1OCO2 ZAALQOFZFANFTF-UHFFFAOYSA-N 0.000 description 1
- 102100037860 Psychosine receptor Human genes 0.000 description 1
- 101150034985 Ptgdr2 gene Proteins 0.000 description 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 description 1
- 206010037688 Q fever Diseases 0.000 description 1
- 102100033479 RAF proto-oncogene serine/threonine-protein kinase Human genes 0.000 description 1
- 101710141955 RAF proto-oncogene serine/threonine-protein kinase Proteins 0.000 description 1
- 229940124875 RabAvert Drugs 0.000 description 1
- 108010038036 Receptor Activator of Nuclear Factor-kappa B Proteins 0.000 description 1
- 102000010498 Receptor Activator of Nuclear Factor-kappa B Human genes 0.000 description 1
- 102000004278 Receptor Protein-Tyrosine Kinases Human genes 0.000 description 1
- 108090000873 Receptor Protein-Tyrosine Kinases Proteins 0.000 description 1
- 102000016983 Releasing hormones receptors Human genes 0.000 description 1
- 108070000025 Releasing hormones receptors Proteins 0.000 description 1
- 241000725643 Respiratory syncytial virus Species 0.000 description 1
- 108091011168 Rhodopsin kinase GRK1 Proteins 0.000 description 1
- 108010034782 Ribosomal Protein S6 Kinases Proteins 0.000 description 1
- 102000009738 Ribosomal Protein S6 Kinases Human genes 0.000 description 1
- 239000008156 Ringer's lactate solution Substances 0.000 description 1
- 101150035397 Ros1 gene Proteins 0.000 description 1
- 229940124878 RotaTeq Drugs 0.000 description 1
- 229940124941 Rotarix Drugs 0.000 description 1
- 229940124859 Rotavirus vaccine Drugs 0.000 description 1
- 241000219053 Rumex Species 0.000 description 1
- 108091006614 SLC10A2 Proteins 0.000 description 1
- 108091006621 SLC12A1 Proteins 0.000 description 1
- 108091006623 SLC12A3 Proteins 0.000 description 1
- 108091006633 SLC12A6 Proteins 0.000 description 1
- 108091006419 SLC25A12 Proteins 0.000 description 1
- 108091006307 SLC2A10 Proteins 0.000 description 1
- 108091006299 SLC2A2 Proteins 0.000 description 1
- 108091006303 SLC2A9 Proteins 0.000 description 1
- 208000022122 SLC35A1-CDG Diseases 0.000 description 1
- 108091006277 SLC5A1 Proteins 0.000 description 1
- 108091006269 SLC5A2 Proteins 0.000 description 1
- 108091006657 SLC9A6 Proteins 0.000 description 1
- 108091006731 SLCO1B1 Proteins 0.000 description 1
- 108091006730 SLCO1B3 Proteins 0.000 description 1
- 108091006791 SLCO2A1 Proteins 0.000 description 1
- 101150100424 SPX4 gene Proteins 0.000 description 1
- 102000001332 SRC Human genes 0.000 description 1
- 108060006706 SRC Proteins 0.000 description 1
- 102400000827 Saposin-D Human genes 0.000 description 1
- 101800001700 Saposin-D Proteins 0.000 description 1
- 108010086019 Secretin Proteins 0.000 description 1
- 102100037505 Secretin Human genes 0.000 description 1
- 102100028927 Secretin receptor Human genes 0.000 description 1
- 102100027103 Serine/threonine-protein kinase B-raf Human genes 0.000 description 1
- 102100031081 Serine/threonine-protein kinase Chk1 Human genes 0.000 description 1
- 102100037310 Serine/threonine-protein kinase D1 Human genes 0.000 description 1
- 102100037345 Serine/threonine-protein kinase NIM1 Human genes 0.000 description 1
- 101710095079 Serine/threonine-protein kinase NIM1 Proteins 0.000 description 1
- 102100028868 Serine/threonine-protein kinase PRP4 homolog Human genes 0.000 description 1
- 102100030070 Serine/threonine-protein kinase Sgk1 Human genes 0.000 description 1
- 102100038192 Serine/threonine-protein kinase TBK1 Human genes 0.000 description 1
- 101710106944 Serine/threonine-protein kinase TBK1 Proteins 0.000 description 1
- 102100037670 Serine/threonine-protein kinase TNNI3K Human genes 0.000 description 1
- 101710178685 Serine/threonine-protein kinase TNNI3K Proteins 0.000 description 1
- 102100028234 Serine/threonine-protein kinase VRK2 Human genes 0.000 description 1
- 101710196279 Serine/threonine-protein kinase VRK2 Proteins 0.000 description 1
- 102100029332 Serine/threonine-protein kinase haspin Human genes 0.000 description 1
- 102100036120 Serine/threonine-protein kinase pim-2 Human genes 0.000 description 1
- 102100036119 Serine/threonine-protein kinase pim-3 Human genes 0.000 description 1
- 102100023105 Sialin Human genes 0.000 description 1
- 102100024453 Signaling threshold-regulating transmembrane adapter 1 Human genes 0.000 description 1
- 101150086693 Slc17a8 gene Proteins 0.000 description 1
- 101150038440 Slc39a13 gene Proteins 0.000 description 1
- 102100023153 Sodium- and chloride-dependent creatine transporter 1 Human genes 0.000 description 1
- 102100037189 Sodium- and chloride-dependent transporter XTRP3 Human genes 0.000 description 1
- 108010087132 Sodium-Bicarbonate Symporters Proteins 0.000 description 1
- 102000058090 Sodium-Glucose Transporter 1 Human genes 0.000 description 1
- 102000058081 Sodium-Glucose Transporter 2 Human genes 0.000 description 1
- 102100029972 Sodium/hydrogen exchanger 6 Human genes 0.000 description 1
- 102100032079 Sodium/potassium/calcium exchanger 5 Human genes 0.000 description 1
- 108010038615 Solute Carrier Family 22 Member 5 Proteins 0.000 description 1
- 102100025671 Solute carrier family 12 member 1 Human genes 0.000 description 1
- 102100034261 Solute carrier family 12 member 3 Human genes 0.000 description 1
- 102100034245 Solute carrier family 12 member 6 Human genes 0.000 description 1
- 102100039667 Solute carrier family 2, facilitated glucose transporter member 11 Human genes 0.000 description 1
- 102100023537 Solute carrier family 2, facilitated glucose transporter member 2 Human genes 0.000 description 1
- 102100022720 Solute carrier family 2, facilitated glucose transporter member 6 Human genes 0.000 description 1
- 102100021495 Solute carrier family 22 member 12 Human genes 0.000 description 1
- 102100036924 Solute carrier family 22 member 5 Human genes 0.000 description 1
- 102100036930 Solute carrier family 22 member 6 Human genes 0.000 description 1
- 101710102683 Solute carrier family 22 member 6 Proteins 0.000 description 1
- 101710111423 Solute carrier family 40 member 1 Proteins 0.000 description 1
- 102100036863 Solute carrier family 52, riboflavin transporter, member 1 Human genes 0.000 description 1
- 102100036862 Solute carrier family 52, riboflavin transporter, member 2 Human genes 0.000 description 1
- 102100036865 Solute carrier family 52, riboflavin transporter, member 3 Human genes 0.000 description 1
- 101710102466 Solute carrier family 52, riboflavin transporter, member 3 Proteins 0.000 description 1
- 102100027233 Solute carrier organic anion transporter family member 1B1 Human genes 0.000 description 1
- 102100027239 Solute carrier organic anion transporter family member 1B3 Human genes 0.000 description 1
- 102100027187 Solute carrier organic anion transporter family member 2A1 Human genes 0.000 description 1
- 108010068542 Somatotropin Receptors Proteins 0.000 description 1
- 102000011011 Sphingosine 1-phosphate receptors Human genes 0.000 description 1
- 108050001083 Sphingosine 1-phosphate receptors Proteins 0.000 description 1
- 102100024690 Spliceosome RNA helicase DDX39B Human genes 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 108010074438 Sterol Regulatory Element Binding Protein 2 Proteins 0.000 description 1
- 102100026841 Sterol regulatory element-binding protein 2 Human genes 0.000 description 1
- 241000193998 Streptococcus pneumoniae Species 0.000 description 1
- 241000193996 Streptococcus pyogenes Species 0.000 description 1
- 239000002174 Styrene-butadiene Substances 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 101710083705 Sulfotransferase 4A1 Proteins 0.000 description 1
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 description 1
- 229940124930 TENIVAC Drugs 0.000 description 1
- 108010010057 TYK2 Kinase Proteins 0.000 description 1
- 229940124929 TYPHIM Vi Drugs 0.000 description 1
- 229940126624 Tacatuzumab tetraxetan Drugs 0.000 description 1
- 102000007124 Tachykinin Receptors Human genes 0.000 description 1
- 108010072901 Tachykinin Receptors Proteins 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- CBPNZQVSJQDFBE-FUXHJELOSA-N Temsirolimus Chemical compound C1C[C@@H](OC(=O)C(C)(CO)CO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 CBPNZQVSJQDFBE-FUXHJELOSA-N 0.000 description 1
- 102100029350 Testis-specific serine/threonine-protein kinase 1 Human genes 0.000 description 1
- 101710116855 Testis-specific serine/threonine-protein kinase 1 Proteins 0.000 description 1
- 206010043376 Tetanus Diseases 0.000 description 1
- 102100030104 Thiamine transporter 1 Human genes 0.000 description 1
- 102100030103 Thiamine transporter 2 Human genes 0.000 description 1
- WKDDRNSBRWANNC-UHFFFAOYSA-N Thienamycin Natural products C1C(SCCN)=C(C(O)=O)N2C(=O)C(C(O)C)C21 WKDDRNSBRWANNC-UHFFFAOYSA-N 0.000 description 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
- 239000004473 Threonine Substances 0.000 description 1
- 108010000499 Thromboplastin Proteins 0.000 description 1
- 102000011923 Thyrotropin Human genes 0.000 description 1
- 108010061174 Thyrotropin Proteins 0.000 description 1
- 102000003911 Thyrotropin Receptors Human genes 0.000 description 1
- 108090000253 Thyrotropin Receptors Proteins 0.000 description 1
- 239000000627 Thyrotropin-Releasing Hormone Substances 0.000 description 1
- 102400000336 Thyrotropin-releasing hormone Human genes 0.000 description 1
- 101800004623 Thyrotropin-releasing hormone Proteins 0.000 description 1
- 108090000373 Tissue Plasminogen Activator Proteins 0.000 description 1
- 102000003978 Tissue Plasminogen Activator Human genes 0.000 description 1
- 102100030859 Tissue factor Human genes 0.000 description 1
- 102000015862 Transcription initiation factor TFIID subunit 1 Human genes 0.000 description 1
- 108050004072 Transcription initiation factor TFIID subunit 1 Proteins 0.000 description 1
- 108010009583 Transforming Growth Factors Proteins 0.000 description 1
- 102000009618 Transforming Growth Factors Human genes 0.000 description 1
- 108010037150 Transient Receptor Potential Channels Proteins 0.000 description 1
- 102000011753 Transient Receptor Potential Channels Human genes 0.000 description 1
- XGMPVBXKDAHORN-RBWIMXSLSA-N Triamcinolone diacetate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](OC(C)=O)[C@@](C(=O)COC(=O)C)(O)[C@@]1(C)C[C@@H]2O XGMPVBXKDAHORN-RBWIMXSLSA-N 0.000 description 1
- TZIZWYVVGLXXFV-FLRHRWPCSA-N Triamcinolone hexacetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)COC(=O)CC(C)(C)C)[C@@]1(C)C[C@@H]2O TZIZWYVVGLXXFV-FLRHRWPCSA-N 0.000 description 1
- OGQXAZJUVVPCRL-UHFFFAOYSA-N Tropin-alpha-methyl-buttersaeure-ester Natural products C1C(OC(=O)C(C)CC)CC2CCC1N2C OGQXAZJUVVPCRL-UHFFFAOYSA-N 0.000 description 1
- 102000004243 Tubulin Human genes 0.000 description 1
- 108090000704 Tubulin Proteins 0.000 description 1
- 208000034784 Tularaemia Diseases 0.000 description 1
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 description 1
- 239000004182 Tylosin Substances 0.000 description 1
- 229930194936 Tylosin Natural products 0.000 description 1
- 108010057266 Type A Botulinum Toxins Proteins 0.000 description 1
- 208000037386 Typhoid Diseases 0.000 description 1
- 102100039127 Tyrosine-protein kinase receptor TYRO3 Human genes 0.000 description 1
- 101710148271 UDP-glucose:glycoprotein glucosyltransferase 1 Proteins 0.000 description 1
- 102100023407 Uracil nucleotide/cysteinyl leukotriene receptor Human genes 0.000 description 1
- 108010047196 Urofollitropin Proteins 0.000 description 1
- 102000003990 Urokinase-type plasminogen activator Human genes 0.000 description 1
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 description 1
- 108010053099 Vascular Endothelial Growth Factor Receptor-2 Proteins 0.000 description 1
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 description 1
- 102100038388 Vasoactive intestinal polypeptide receptor 1 Human genes 0.000 description 1
- 101710137655 Vasoactive intestinal polypeptide receptor 1 Proteins 0.000 description 1
- GXBMIBRIOWHPDT-UHFFFAOYSA-N Vasopressin Natural products N1C(=O)C(CC=2C=C(O)C=CC=2)NC(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C1CC1=CC=CC=C1 GXBMIBRIOWHPDT-UHFFFAOYSA-N 0.000 description 1
- 102000004136 Vasopressin Receptors Human genes 0.000 description 1
- 108090000643 Vasopressin Receptors Proteins 0.000 description 1
- 108010004977 Vasopressins Proteins 0.000 description 1
- 102000002852 Vasopressins Human genes 0.000 description 1
- 102100038033 Vesicular glutamate transporter 3 Human genes 0.000 description 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 1
- 206010047505 Visceral leishmaniasis Diseases 0.000 description 1
- 102100023037 Wee1-like protein kinase Human genes 0.000 description 1
- 241000710886 West Nile virus Species 0.000 description 1
- 101001001642 Xenopus laevis Serine/threonine-protein kinase pim-3 Proteins 0.000 description 1
- 229940124928 YF-Vax Drugs 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- 102100023140 Zinc transporter ZIP4 Human genes 0.000 description 1
- 239000005870 Ziram Substances 0.000 description 1
- OUUYBRCCFUEMLH-YDALLXLXSA-N [(1s)-2-[4-[bis(2-chloroethyl)amino]phenyl]-1-carboxyethyl]azanium;chloride Chemical compound Cl.OC(=O)[C@@H](N)CC1=CC=C(N(CCCl)CCCl)C=C1 OUUYBRCCFUEMLH-YDALLXLXSA-N 0.000 description 1
- IHHXIUAEPKVVII-ZSCHJXSPSA-N [(1s)-5-amino-1-carboxypentyl]azanium;2-[4-(2-methylpropyl)phenyl]propanoate Chemical compound OC(=O)[C@@H](N)CCCC[NH3+].CC(C)CC1=CC=C(C(C)C([O-])=O)C=C1 IHHXIUAEPKVVII-ZSCHJXSPSA-N 0.000 description 1
- XYVNHPYNSPGYLI-UUOKFMHZSA-N [(2r,3s,4r,5r)-5-(2-amino-6-oxo-3h-purin-9-yl)-4-hydroxy-2-(phosphonooxymethyl)oxolan-3-yl] dihydrogen phosphate Chemical compound C1=2NC(N)=NC(=O)C=2N=CN1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H]1O XYVNHPYNSPGYLI-UUOKFMHZSA-N 0.000 description 1
- RXDLGFMMQFNVLI-UHFFFAOYSA-N [Na].[Na].[Ca] Chemical compound [Na].[Na].[Ca] RXDLGFMMQFNVLI-UHFFFAOYSA-N 0.000 description 1
- 108010023617 abarelix Proteins 0.000 description 1
- AIWRTTMUVOZGPW-HSPKUQOVSA-N abarelix Chemical compound C([C@@H](C(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@H](C)C(N)=O)N(C)C(=O)[C@H](CO)NC(=O)[C@@H](CC=1C=NC=CC=1)NC(=O)[C@@H](CC=1C=CC(Cl)=CC=1)NC(=O)[C@@H](CC=1C=C2C=CC=CC2=CC=1)NC(C)=O)C1=CC=C(O)C=C1 AIWRTTMUVOZGPW-HSPKUQOVSA-N 0.000 description 1
- 229960002184 abarelix Drugs 0.000 description 1
- 229950005008 abituzumab Drugs 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 229940048171 acetazolamide injection Drugs 0.000 description 1
- FHEAIOHRHQGZPC-KIWGSFCNSA-N acetic acid;(2s)-2-amino-3-(4-hydroxyphenyl)propanoic acid;(2s)-2-aminopentanedioic acid;(2s)-2-aminopropanoic acid;(2s)-2,6-diaminohexanoic acid Chemical compound CC(O)=O.C[C@H](N)C(O)=O.NCCCC[C@H](N)C(O)=O.OC(=O)[C@@H](N)CCC(O)=O.OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 FHEAIOHRHQGZPC-KIWGSFCNSA-N 0.000 description 1
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 1
- 229940021715 acetylcysteine injection Drugs 0.000 description 1
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 description 1
- 229940119059 actemra Drugs 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000488 activin Substances 0.000 description 1
- 108010023082 activin A Proteins 0.000 description 1
- 208000021841 acute erythroid leukemia Diseases 0.000 description 1
- 229960002964 adalimumab Drugs 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 229940068274 adenosine injection Drugs 0.000 description 1
- 229940021704 adenovirus vaccine Drugs 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000001919 adrenal effect Effects 0.000 description 1
- 230000001800 adrenalinergic effect Effects 0.000 description 1
- 210000002945 adventitial reticular cell Anatomy 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 229940022705 aldurazyme Drugs 0.000 description 1
- 108010060162 alglucerase Proteins 0.000 description 1
- 229960004593 alglucosidase alfa Drugs 0.000 description 1
- 229960004539 alirocumab Drugs 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 229940098174 alkeran Drugs 0.000 description 1
- 229960003235 allopurinol sodium Drugs 0.000 description 1
- 229940062334 aloprim Drugs 0.000 description 1
- 108010028144 alpha-Glucosidases Proteins 0.000 description 1
- 108010084650 alpha-N-arabinofuranosidase Proteins 0.000 description 1
- 229940040476 alsuma Drugs 0.000 description 1
- 229960003318 alteplase Drugs 0.000 description 1
- 229950001537 amatuximab Drugs 0.000 description 1
- 229960005260 amiodarone Drugs 0.000 description 1
- IYIKLHRQXLHMJQ-UHFFFAOYSA-N amiodarone Chemical compound CCCCC=1OC2=CC=CC=C2C=1C(=O)C1=CC(I)=C(OCCN(CC)CC)C(I)=C1 IYIKLHRQXLHMJQ-UHFFFAOYSA-N 0.000 description 1
- SWLVFNYSXGMGBS-UHFFFAOYSA-N ammonium bromide Chemical compound [NH4+].[Br-] SWLVFNYSXGMGBS-UHFFFAOYSA-N 0.000 description 1
- 229940064746 ammonul Drugs 0.000 description 1
- 229940042450 amphadase Drugs 0.000 description 1
- 210000002255 anal canal Anatomy 0.000 description 1
- 108700024685 ancestim Proteins 0.000 description 1
- 229940059707 anzemet Drugs 0.000 description 1
- 229940112930 apidra Drugs 0.000 description 1
- 229940114079 arachidonic acid Drugs 0.000 description 1
- 235000021342 arachidonic acid Nutrition 0.000 description 1
- 229940115115 aranesp Drugs 0.000 description 1
- 229960000271 arbutin Drugs 0.000 description 1
- KXNPVXPOPUZYGB-XYVMCAHJSA-N argatroban Chemical compound OC(=O)[C@H]1C[C@H](C)CCN1C(=O)[C@H](CCCN=C(N)N)NS(=O)(=O)C1=CC=CC2=C1NC[C@H](C)C2 KXNPVXPOPUZYGB-XYVMCAHJSA-N 0.000 description 1
- 229960003856 argatroban Drugs 0.000 description 1
- 229940033590 argatroban injection Drugs 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 229960003121 arginine Drugs 0.000 description 1
- 229960003589 arginine hydrochloride Drugs 0.000 description 1
- KBZOIRJILGZLEJ-LGYYRGKSSA-N argipressin Chemical compound C([C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@@H](C(N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)=O)N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C1=CC=CC=C1 KBZOIRJILGZLEJ-LGYYRGKSSA-N 0.000 description 1
- 229940087508 aristospan Drugs 0.000 description 1
- 238000003491 array Methods 0.000 description 1
- 229940030689 arsenic trioxide injection Drugs 0.000 description 1
- 229960003831 articaine Drugs 0.000 description 1
- 229940091102 asclera Drugs 0.000 description 1
- 108010038640 atrial natriuretic factor receptor A Proteins 0.000 description 1
- 230000002567 autonomic effect Effects 0.000 description 1
- 210000000467 autonomic pathway Anatomy 0.000 description 1
- 229950002916 avelumab Drugs 0.000 description 1
- 230000004323 axial length Effects 0.000 description 1
- 229960004099 azithromycin Drugs 0.000 description 1
- MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 description 1
- 229960003644 aztreonam Drugs 0.000 description 1
- 229960000190 bacillus calmette–guérin vaccine Drugs 0.000 description 1
- 239000008228 bacteriostatic water for injection Substances 0.000 description 1
- 229940058606 bal in oil Drugs 0.000 description 1
- 210000004082 barrier epithelial cell Anatomy 0.000 description 1
- 229960004669 basiliximab Drugs 0.000 description 1
- 210000003651 basophil Anatomy 0.000 description 1
- 229950003269 bectumomab Drugs 0.000 description 1
- 229960004965 begelomab Drugs 0.000 description 1
- 229960003270 belimumab Drugs 0.000 description 1
- 229940043761 bendamustine injection Drugs 0.000 description 1
- 229940022836 benlysta Drugs 0.000 description 1
- 229940024774 benztropine mesylate Drugs 0.000 description 1
- BVGLIYRKPOITBQ-ANPZCEIESA-N benzylpenicillin benzathine Chemical compound C=1C=CC=CC=1C[NH2+]CC[NH2+]CC1=CC=CC=C1.N([C@H]1[C@H]2SC([C@@H](N2C1=O)C([O-])=O)(C)C)C(=O)CC1=CC=CC=C1.N([C@H]1[C@H]2SC([C@@H](N2C1=O)C([O-])=O)(C)C)C(=O)CC1=CC=CC=C1 BVGLIYRKPOITBQ-ANPZCEIESA-N 0.000 description 1
- WHRVRSCEWKLAHX-LQDWTQKMSA-N benzylpenicillin procaine Chemical compound [H+].CCN(CC)CCOC(=O)C1=CC=C(N)C=C1.N([C@H]1[C@H]2SC([C@@H](N2C1=O)C([O-])=O)(C)C)C(=O)CC1=CC=CC=C1 WHRVRSCEWKLAHX-LQDWTQKMSA-N 0.000 description 1
- 102000012740 beta Adrenergic Receptors Human genes 0.000 description 1
- 108010079452 beta Adrenergic Receptors Proteins 0.000 description 1
- 229940006071 betamethasone injectable suspension Drugs 0.000 description 1
- 229960000397 bevacizumab Drugs 0.000 description 1
- 229940090821 bexsero Drugs 0.000 description 1
- 229950002853 bimekizumab Drugs 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 229960000074 biopharmaceutical Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229960005522 bivatuzumab mertansine Drugs 0.000 description 1
- 229960001561 bleomycin Drugs 0.000 description 1
- OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 description 1
- 229960004395 bleomycin sulfate Drugs 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 210000002449 bone cell Anatomy 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 229940066189 botox cosmetic Drugs 0.000 description 1
- 229940054242 bravelle Drugs 0.000 description 1
- 229940088499 brethine Drugs 0.000 description 1
- 229960002624 bretylium tosilate Drugs 0.000 description 1
- KVWNWTZZBKCOPM-UHFFFAOYSA-M bretylium tosylate Chemical compound CC1=CC=C(S([O-])(=O)=O)C=C1.CC[N+](C)(C)CC1=CC=CC=C1Br KVWNWTZZBKCOPM-UHFFFAOYSA-M 0.000 description 1
- 229960003735 brodalumab Drugs 0.000 description 1
- 229950000025 brolucizumab Drugs 0.000 description 1
- 125000001246 bromo group Chemical group Br* 0.000 description 1
- 229920005557 bromobutyl Polymers 0.000 description 1
- 210000000233 bronchiolar non-ciliated Anatomy 0.000 description 1
- 239000013590 bulk material Substances 0.000 description 1
- 229960001050 bupivacaine hydrochloride Drugs 0.000 description 1
- 229940013767 bupivacaine injection Drugs 0.000 description 1
- 229950002817 burosumab Drugs 0.000 description 1
- MTAZNLWOLGHBHU-UHFFFAOYSA-N butadiene-styrene rubber Chemical compound C=CC=C.C=CC1=CC=CC=C1 MTAZNLWOLGHBHU-UHFFFAOYSA-N 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 102100029402 cAMP-dependent protein kinase catalytic subunit PRKX Human genes 0.000 description 1
- 229950010831 cabiralizumab Drugs 0.000 description 1
- 229960001948 caffeine Drugs 0.000 description 1
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 1
- 229940023964 caffeine and sodium benzoate Drugs 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 235000008207 calcium folinate Nutrition 0.000 description 1
- 239000011687 calcium folinate Substances 0.000 description 1
- JHECKPXUCKQCSH-UHFFFAOYSA-J calcium;disodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate;hydrate Chemical compound O.[Na+].[Na+].[Ca+2].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O JHECKPXUCKQCSH-UHFFFAOYSA-J 0.000 description 1
- ZEWYCNBZMPELPF-UHFFFAOYSA-J calcium;potassium;sodium;2-hydroxypropanoic acid;sodium;tetrachloride Chemical compound [Na].[Na+].[Cl-].[Cl-].[Cl-].[Cl-].[K+].[Ca+2].CC(O)C(O)=O ZEWYCNBZMPELPF-UHFFFAOYSA-J 0.000 description 1
- 229960001838 canakinumab Drugs 0.000 description 1
- 229950011547 cantuzumab ravtansine Drugs 0.000 description 1
- 229940034605 capromab pendetide Drugs 0.000 description 1
- 210000004413 cardiac myocyte Anatomy 0.000 description 1
- 229950000771 carlumab Drugs 0.000 description 1
- 229950005629 carotuximab Drugs 0.000 description 1
- 229940015688 caverject Drugs 0.000 description 1
- 210000003068 cdc Anatomy 0.000 description 1
- 108010051348 cdc42 GTP-Binding Protein Proteins 0.000 description 1
- 229960000927 cefepime hydrochloride Drugs 0.000 description 1
- AZZMGZXNTDTSME-JUZDKLSSSA-M cefotaxime sodium Chemical compound [Na+].N([C@@H]1C(N2C(=C(COC(C)=O)CS[C@@H]21)C([O-])=O)=O)C(=O)\C(=N/OC)C1=CSC(N)=N1 AZZMGZXNTDTSME-JUZDKLSSSA-M 0.000 description 1
- 229960002727 cefotaxime sodium Drugs 0.000 description 1
- 229960005446 cefpiramide Drugs 0.000 description 1
- PWAUCHMQEXVFJR-PMAPCBKXSA-N cefpiramide Chemical compound C1=NC(C)=CC(O)=C1C(=O)N[C@H](C=1C=CC(O)=CC=1)C(=O)N[C@@H]1C(=O)N2C(C(O)=O)=C(CSC=3N(N=NN=3)C)CS[C@@H]21 PWAUCHMQEXVFJR-PMAPCBKXSA-N 0.000 description 1
- 229960000590 celecoxib Drugs 0.000 description 1
- RZEKVGVHFLEQIL-UHFFFAOYSA-N celecoxib Chemical compound C1=CC(C)=CC=C1C1=CC(C(F)(F)F)=NN1C1=CC=C(S(N)(=O)=O)C=C1 RZEKVGVHFLEQIL-UHFFFAOYSA-N 0.000 description 1
- 229940079135 celestone soluspan Drugs 0.000 description 1
- 230000022131 cell cycle Effects 0.000 description 1
- 210000003986 cell retinal photoreceptor Anatomy 0.000 description 1
- 238000002659 cell therapy Methods 0.000 description 1
- 210000000250 cementoblast Anatomy 0.000 description 1
- 229910010293 ceramic material Inorganic materials 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 229950002256 cergutuzumab amunaleukin Drugs 0.000 description 1
- 229960003115 certolizumab pegol Drugs 0.000 description 1
- 210000002939 cerumen Anatomy 0.000 description 1
- 229960001803 cetirizine Drugs 0.000 description 1
- 238000012668 chain scission Methods 0.000 description 1
- QTFFGPOXNNGTGZ-LIFGOUTFSA-N chembl2368924 Chemical compound O.CS(O)(=O)=O.C1=CC=C2C(C(O[C@@H]3C[C@@H]4C[C@H]5C[C@@H](N4CC5=O)C3)=O)=CNC2=C1 QTFFGPOXNNGTGZ-LIFGOUTFSA-N 0.000 description 1
- 229960005091 chloramphenicol Drugs 0.000 description 1
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 1
- 229960002579 chloramphenicol sodium succinate Drugs 0.000 description 1
- 229960004782 chlordiazepoxide Drugs 0.000 description 1
- ANTSCNMPPGJYLG-UHFFFAOYSA-N chlordiazepoxide Chemical compound O=N=1CC(NC)=NC2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 ANTSCNMPPGJYLG-UHFFFAOYSA-N 0.000 description 1
- 229920005556 chlorobutyl Polymers 0.000 description 1
- 229960005004 cholera vaccine Drugs 0.000 description 1
- 230000001713 cholinergic effect Effects 0.000 description 1
- 210000001726 chromosome structure Anatomy 0.000 description 1
- 229960004912 cilastatin Drugs 0.000 description 1
- 210000000254 ciliated cell Anatomy 0.000 description 1
- 229960003315 cinacalcet Drugs 0.000 description 1
- VDHAWDNDOKGFTD-MRXNPFEDSA-N cinacalcet Chemical compound N([C@H](C)C=1C2=CC=CC=C2C=CC=1)CCCC1=CC=CC(C(F)(F)F)=C1 VDHAWDNDOKGFTD-MRXNPFEDSA-N 0.000 description 1
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 1
- 229960004316 cisplatin Drugs 0.000 description 1
- 229940105442 cisplatin injection Drugs 0.000 description 1
- 229950010905 citatuzumab bogatox Drugs 0.000 description 1
- 108010084210 citrin Proteins 0.000 description 1
- 229940038649 clavulanate potassium Drugs 0.000 description 1
- 229950002334 clenoliximab Drugs 0.000 description 1
- 229960000928 clofarabine Drugs 0.000 description 1
- 229940103380 clolar Drugs 0.000 description 1
- 229940046989 clomiphene citrate Drugs 0.000 description 1
- 229940078069 clonidine injection Drugs 0.000 description 1
- 230000003081 coactivator Effects 0.000 description 1
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 description 1
- 229960003920 cocaine Drugs 0.000 description 1
- 229950007906 codrituzumab Drugs 0.000 description 1
- 229940097480 cogentin Drugs 0.000 description 1
- 229960000674 colesevelam hydrochloride Drugs 0.000 description 1
- 229940047120 colony stimulating factors Drugs 0.000 description 1
- 229950005458 coltuximab ravtansine Drugs 0.000 description 1
- 229950007276 conatumumab Drugs 0.000 description 1
- 229950009735 concizumab Drugs 0.000 description 1
- 201000001575 congenital disorder of glycosylation type IIc Diseases 0.000 description 1
- 201000001594 congenital disorder of glycosylation type IIf Diseases 0.000 description 1
- 201000000728 congenital hereditary endothelial dystrophy of cornea Diseases 0.000 description 1
- BTYHAFSDANBVMJ-UHFFFAOYSA-N conivaptan hydrochloride Chemical compound Cl.C12=CC=CC=C2C=2NC(C)=NC=2CCN1C(=O)C(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=CC=C1 BTYHAFSDANBVMJ-UHFFFAOYSA-N 0.000 description 1
- 229940031670 conjugate vaccine Drugs 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 210000004087 cornea Anatomy 0.000 description 1
- 210000003239 corneal fibroblast Anatomy 0.000 description 1
- 210000004246 corpus luteum Anatomy 0.000 description 1
- 230000001054 cortical effect Effects 0.000 description 1
- 229960001809 corticorelin ovine triflutate Drugs 0.000 description 1
- IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 description 1
- 229960000258 corticotropin Drugs 0.000 description 1
- 229940042783 corvert Drugs 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 101150006264 ctb-1 gene Proteins 0.000 description 1
- 229940029525 cyanokit Drugs 0.000 description 1
- 229940077926 cytarabine liposome injection Drugs 0.000 description 1
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 1
- 229940087451 cytovene Drugs 0.000 description 1
- 229960002806 daclizumab Drugs 0.000 description 1
- 229940059359 dacogen Drugs 0.000 description 1
- 229960002482 dalotuzumab Drugs 0.000 description 1
- 229960004969 dalteparin Drugs 0.000 description 1
- 229960003710 dantrolene sodium Drugs 0.000 description 1
- LTWQNYPDAUSXBC-CDJGKPBYSA-L dantrolene sodium hemiheptahydrate Chemical compound O.O.O.O.O.O.O.[Na+].[Na+].C1=CC([N+](=O)[O-])=CC=C1C(O1)=CC=C1\C=N\N1C(=O)[N-]C(=O)C1.C1=CC([N+](=O)[O-])=CC=C1C(O1)=CC=C1\C=N\N1C(=O)[N-]C(=O)C1 LTWQNYPDAUSXBC-CDJGKPBYSA-L 0.000 description 1
- 229950005026 dapirolizumab pegol Drugs 0.000 description 1
- 108010048522 dapirolizumab pegol Proteins 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 229940075844 delatestryl Drugs 0.000 description 1
- 229940005558 delestrogen Drugs 0.000 description 1
- 210000004443 dendritic cell Anatomy 0.000 description 1
- 208000025729 dengue disease Diseases 0.000 description 1
- 229950004079 denintuzumab mafodotin Drugs 0.000 description 1
- 229960001251 denosumab Drugs 0.000 description 1
- 208000002925 dental caries Diseases 0.000 description 1
- 210000004268 dentin Anatomy 0.000 description 1
- 229950008925 depatuxizumab mafodotin Drugs 0.000 description 1
- 229940003382 depo-medrol Drugs 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 108010073652 desirudin Proteins 0.000 description 1
- 229960002845 desmopressin acetate Drugs 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 239000008356 dextrose and sodium chloride injection Substances 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- OEBRKCOSUFCWJD-UHFFFAOYSA-N dichlorvos Chemical compound COP(=O)(OC)OC=C(Cl)Cl OEBRKCOSUFCWJD-UHFFFAOYSA-N 0.000 description 1
- CHWPMFMUQATVNK-ARYYTZDLSA-N dihydrosporogen AO-1 Natural products O[C@H]1[C@]2(C(C)=C)O[C@@H]2[C@]2(C)[C@@H](C)[C@H](O)CCC2=C1 CHWPMFMUQATVNK-ARYYTZDLSA-N 0.000 description 1
- 229940099212 dilaudid Drugs 0.000 description 1
- WQABCVAJNWAXTE-UHFFFAOYSA-N dimercaprol Chemical compound OCC(S)CS WQABCVAJNWAXTE-UHFFFAOYSA-N 0.000 description 1
- GGWBHVILAJZWKJ-UHFFFAOYSA-N dimethyl-[[5-[2-[[1-(methylamino)-2-nitroethenyl]amino]ethylsulfanylmethyl]furan-2-yl]methyl]azanium;chloride Chemical compound Cl.[O-][N+](=O)C=C(NC)NCCSCC1=CC=C(CN(C)C)O1 GGWBHVILAJZWKJ-UHFFFAOYSA-N 0.000 description 1
- 229960004497 dinutuximab Drugs 0.000 description 1
- 229940030136 diphenhydramine injection Drugs 0.000 description 1
- 229950011037 diridavumab Drugs 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 210000005232 distal tubule cell Anatomy 0.000 description 1
- 229950005168 dorlimomab aritox Drugs 0.000 description 1
- 230000012361 double-strand break repair Effects 0.000 description 1
- 229940063519 doxorubicin hydrochloride liposome Drugs 0.000 description 1
- 229950009964 drozitumab Drugs 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 229950006432 duligotuzumab Drugs 0.000 description 1
- 230000002183 duodenal effect Effects 0.000 description 1
- 229940089529 duramorph Drugs 0.000 description 1
- 229950009791 durvalumab Drugs 0.000 description 1
- 229950011453 dusigitumab Drugs 0.000 description 1
- 102000013035 dynein heavy chain Human genes 0.000 description 1
- 108060002430 dynein heavy chain Proteins 0.000 description 1
- 229950000006 ecromeximab Drugs 0.000 description 1
- 210000003981 ectoderm Anatomy 0.000 description 1
- 229940009662 edetate Drugs 0.000 description 1
- 229940113960 edetate calcium Drugs 0.000 description 1
- 229940095629 edetate calcium disodium Drugs 0.000 description 1
- 229940013191 edex Drugs 0.000 description 1
- 229950011109 edobacomab Drugs 0.000 description 1
- 229960003748 edrophonium Drugs 0.000 description 1
- 229960000284 efalizumab Drugs 0.000 description 1
- 150000002066 eicosanoids Chemical class 0.000 description 1
- 229950010217 eldelumab Drugs 0.000 description 1
- FJZZPCZKBUKGGU-AUSIDOKSSA-N eliglustat Chemical compound C([C@@H](NC(=O)CCCCCCC)[C@H](O)C=1C=C2OCCOC2=CC=1)N1CCCC1 FJZZPCZKBUKGGU-AUSIDOKSSA-N 0.000 description 1
- KUBARPMUNHKBIQ-VTHUDJRQSA-N eliglustat tartrate Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O.C([C@@H](NC(=O)CCCCCCC)[C@H](O)C=1C=C2OCCOC2=CC=1)N1CCCC1.C([C@@H](NC(=O)CCCCCCC)[C@H](O)C=1C=C2OCCOC2=CC=1)N1CCCC1 KUBARPMUNHKBIQ-VTHUDJRQSA-N 0.000 description 1
- 229960004137 elotuzumab Drugs 0.000 description 1
- 210000001671 embryonic stem cell Anatomy 0.000 description 1
- 229940108890 emend Drugs 0.000 description 1
- 229940014768 emend injection Drugs 0.000 description 1
- 229950006925 emicizumab Drugs 0.000 description 1
- 229960002680 enalaprilat Drugs 0.000 description 1
- LZFZMUMEGBBDTC-QEJZJMRPSA-N enalaprilat (anhydrous) Chemical compound C([C@H](N[C@@H](C)C(=O)N1[C@@H](CCC1)C(O)=O)C(O)=O)CC1=CC=CC=C1 LZFZMUMEGBBDTC-QEJZJMRPSA-N 0.000 description 1
- 229950003048 enavatuzumab Drugs 0.000 description 1
- 229940073621 enbrel Drugs 0.000 description 1
- 210000001900 endoderm Anatomy 0.000 description 1
- 210000005168 endometrial cell Anatomy 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 229950004930 enfortumab vedotin Drugs 0.000 description 1
- 229960002062 enfuvirtide Drugs 0.000 description 1
- 229950007313 enokizumab Drugs 0.000 description 1
- 229950001752 enoticumab Drugs 0.000 description 1
- IDYZIJYBMGIQMJ-UHFFFAOYSA-N enoxacin Chemical compound N1=C2N(CC)C=C(C(O)=O)C(=O)C2=CC(F)=C1N1CCNCC1 IDYZIJYBMGIQMJ-UHFFFAOYSA-N 0.000 description 1
- 229960002549 enoxacin Drugs 0.000 description 1
- 229950010640 ensituximab Drugs 0.000 description 1
- 210000001842 enterocyte Anatomy 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 210000003979 eosinophil Anatomy 0.000 description 1
- 229920005558 epichlorohydrin rubber Polymers 0.000 description 1
- 210000001339 epidermal cell Anatomy 0.000 description 1
- 210000005175 epidermal keratinocyte Anatomy 0.000 description 1
- 210000003426 epidermal langerhans cell Anatomy 0.000 description 1
- 229940015979 epipen Drugs 0.000 description 1
- 229950006414 epitumomab cituxetan Drugs 0.000 description 1
- 150000003883 epothilone derivatives Chemical class 0.000 description 1
- 229950009760 epratuzumab Drugs 0.000 description 1
- 229950001616 erenumab Drugs 0.000 description 1
- 229950004292 erlizumab Drugs 0.000 description 1
- AAKJLRGGTJKAMG-UHFFFAOYSA-N erlotinib Chemical compound C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 AAKJLRGGTJKAMG-UHFFFAOYSA-N 0.000 description 1
- 229960001433 erlotinib Drugs 0.000 description 1
- 229940107273 ertapenem injection Drugs 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 229940105423 erythropoietin Drugs 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- 229930182833 estradiol Natural products 0.000 description 1
- 229960005416 estradiol cypionate Drugs 0.000 description 1
- 108010038795 estrogen receptors Proteins 0.000 description 1
- VUCAHVBMSFIGAI-ZFINNJDLSA-M estrone sodium sulfate Chemical compound [Na+].[O-]S(=O)(=O)OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 VUCAHVBMSFIGAI-ZFINNJDLSA-M 0.000 description 1
- QHSJIZLJUFMIFP-UHFFFAOYSA-N ethene;1,1,2,2-tetrafluoroethene Chemical group C=C.FC(F)=C(F)F QHSJIZLJUFMIFP-UHFFFAOYSA-N 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 229960000221 exametazime Drugs 0.000 description 1
- 229940047296 exenatide injection Drugs 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 210000003499 exocrine gland Anatomy 0.000 description 1
- 239000012632 extractable Substances 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 210000000744 eyelid Anatomy 0.000 description 1
- 229960000815 ezetimibe Drugs 0.000 description 1
- OLNTVTPDXPETLC-XPWALMASSA-N ezetimibe Chemical compound N1([C@@H]([C@H](C1=O)CC[C@H](O)C=1C=CC(F)=CC=1)C=1C=CC(O)=CC=1)C1=CC=C(F)C=C1 OLNTVTPDXPETLC-XPWALMASSA-N 0.000 description 1
- 229940012413 factor vii Drugs 0.000 description 1
- 229960000301 factor viii Drugs 0.000 description 1
- 229940012426 factor x Drugs 0.000 description 1
- 229940012444 factor xiii Drugs 0.000 description 1
- 229950009929 farletuzumab Drugs 0.000 description 1
- 229930002886 farnesol Natural products 0.000 description 1
- 229940043259 farnesol Drugs 0.000 description 1
- 229940102709 ferumoxytol Drugs 0.000 description 1
- 229940126612 fibatuzumab Drugs 0.000 description 1
- 229940012952 fibrinogen Drugs 0.000 description 1
- 239000002657 fibrous material Substances 0.000 description 1
- 229950002846 ficlatuzumab Drugs 0.000 description 1
- 210000004904 fingernail bed Anatomy 0.000 description 1
- 229950010043 fletikumab Drugs 0.000 description 1
- 230000009969 flowable effect Effects 0.000 description 1
- 229960005304 fludarabine phosphate Drugs 0.000 description 1
- GIUYCYHIANZCFB-FJFJXFQQSA-N fludarabine phosphate Chemical compound C1=NC=2C(N)=NC(F)=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O GIUYCYHIANZCFB-FJFJXFQQSA-N 0.000 description 1
- 229920001973 fluoroelastomer Polymers 0.000 description 1
- GANXFQTZEVGPPI-UHFFFAOYSA-N fluorosulfonyloxyethene Chemical compound FS(=O)(=O)OC=C GANXFQTZEVGPPI-UHFFFAOYSA-N 0.000 description 1
- 235000008191 folinic acid Nutrition 0.000 description 1
- 239000011672 folinic acid Substances 0.000 description 1
- 229940028334 follicle stimulating hormone Drugs 0.000 description 1
- 229940001300 follistim Drugs 0.000 description 1
- 108010006578 follitropin alfa Proteins 0.000 description 1
- 108010081934 follitropin beta Proteins 0.000 description 1
- 229960001318 fondaparinux Drugs 0.000 description 1
- KANJSNBRCNMZMV-ABRZTLGGSA-N fondaparinux Chemical compound O[C@@H]1[C@@H](NS(O)(=O)=O)[C@@H](OC)O[C@H](COS(O)(=O)=O)[C@H]1O[C@H]1[C@H](OS(O)(=O)=O)[C@@H](O)[C@H](O[C@@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O[C@@H]4[C@@H]([C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O4)NS(O)(=O)=O)[C@H](O3)C(O)=O)O)[C@@H](COS(O)(=O)=O)O2)NS(O)(=O)=O)[C@H](C(O)=O)O1 KANJSNBRCNMZMV-ABRZTLGGSA-N 0.000 description 1
- XEKSTYNIJLDDAZ-JASSWCPGSA-F fondaparinux sodium Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].O[C@@H]1[C@@H](NS([O-])(=O)=O)[C@@H](OC)O[C@H](COS([O-])(=O)=O)[C@H]1O[C@H]1[C@H](OS([O-])(=O)=O)[C@@H](O)[C@H](O[C@@H]2[C@@H]([C@@H](OS([O-])(=O)=O)[C@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O[C@@H]4[C@@H]([C@@H](O)[C@H](O)[C@@H](COS([O-])(=O)=O)O4)NS([O-])(=O)=O)[C@H](O3)C(O)=O)O)[C@@H](COS([O-])(=O)=O)O2)NS([O-])(=O)=O)[C@H](C(O)=O)O1 XEKSTYNIJLDDAZ-JASSWCPGSA-F 0.000 description 1
- 229960003661 fondaparinux sodium Drugs 0.000 description 1
- 229950004923 fontolizumab Drugs 0.000 description 1
- 229940053641 forteo Drugs 0.000 description 1
- 229960002891 fosaprepitant Drugs 0.000 description 1
- 229940108452 foscavir Drugs 0.000 description 1
- 229940087051 fragmin Drugs 0.000 description 1
- 229960000936 fumagillin Drugs 0.000 description 1
- NGGMYCMLYOUNGM-CSDLUJIJSA-M fumagillin(1-) Chemical compound C([C@H]([C@H]([C@@H]1[C@]2(C)[C@H](O2)CC=C(C)C)OC)OC(=O)\C=C\C=C\C=C\C=C\C([O-])=O)C[C@@]21CO2 NGGMYCMLYOUNGM-CSDLUJIJSA-M 0.000 description 1
- 229940099052 fuzeon Drugs 0.000 description 1
- 229940096814 gadobenate dimeglumine Drugs 0.000 description 1
- OCDAWJYGVOLXGZ-VPVMAENOSA-K gadobenate dimeglumine Chemical compound [Gd+3].CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CCN(CC(O)=O)C(C([O-])=O)COCC1=CC=CC=C1 OCDAWJYGVOLXGZ-VPVMAENOSA-K 0.000 description 1
- 229960003935 gadofosveset Drugs 0.000 description 1
- JAOZQVJVXQKQAD-UHFFFAOYSA-K gadolinium(3+);phosphate Chemical compound [Gd+3].[O-]P([O-])([O-])=O JAOZQVJVXQKQAD-UHFFFAOYSA-K 0.000 description 1
- DPNNNPAKRZOSMO-UHFFFAOYSA-K gadoteridol Chemical compound [Gd+3].CC(O)CN1CCN(CC([O-])=O)CCN(CC([O-])=O)CCN(CC([O-])=O)CC1 DPNNNPAKRZOSMO-UHFFFAOYSA-K 0.000 description 1
- 229960005451 gadoteridol Drugs 0.000 description 1
- HBEAOBRDTOXWRZ-UHFFFAOYSA-K gadoversetamide Chemical compound [Gd+3].COCCNC(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CCN(CC([O-])=O)CC(=O)NCCOC HBEAOBRDTOXWRZ-UHFFFAOYSA-K 0.000 description 1
- 229950001109 galiximab Drugs 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 108700032141 ganirelix Proteins 0.000 description 1
- 229960003794 ganirelix Drugs 0.000 description 1
- 108010036598 gastric inhibitory polypeptide receptor Proteins 0.000 description 1
- 229950004792 gavilimomab Drugs 0.000 description 1
- 238000001415 gene therapy Methods 0.000 description 1
- 229960002518 gentamicin Drugs 0.000 description 1
- 229950002026 girentuximab Drugs 0.000 description 1
- 229940042385 glatiramer Drugs 0.000 description 1
- 229960003776 glatiramer acetate Drugs 0.000 description 1
- 229950009672 glembatumumab vedotin Drugs 0.000 description 1
- 210000001282 glomerular podocyte Anatomy 0.000 description 1
- 229930182480 glucuronide Natural products 0.000 description 1
- 150000008134 glucuronides Chemical class 0.000 description 1
- 210000002175 goblet cell Anatomy 0.000 description 1
- 229960001743 golimumab Drugs 0.000 description 1
- 229940047742 golimumab injection Drugs 0.000 description 1
- 229940095895 haldol Drugs 0.000 description 1
- 229920005555 halobutyl Polymers 0.000 description 1
- 125000004968 halobutyl group Chemical group 0.000 description 1
- LNEPOXFFQSENCJ-UHFFFAOYSA-N haloperidol Chemical compound C1CC(O)(C=2C=CC(Cl)=CC=2)CCN1CCCC(=O)C1=CC=C(F)C=C1 LNEPOXFFQSENCJ-UHFFFAOYSA-N 0.000 description 1
- 229940047551 haloperidol injection Drugs 0.000 description 1
- 210000003313 haploid nucleated cell Anatomy 0.000 description 1
- 229940062743 hectorol Drugs 0.000 description 1
- 229910052734 helium Inorganic materials 0.000 description 1
- 239000001307 helium Substances 0.000 description 1
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 1
- 210000002443 helper t lymphocyte Anatomy 0.000 description 1
- 229960004443 hemophilus influenzae b vaccines Drugs 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- SPSXSWRZQFPVTJ-ZQQKUFEYSA-N hepatitis b vaccine Chemical compound C([C@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCSC)C(=O)N[C@@H](CC1N=CN=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)OC(=O)CNC(=O)CNC(=O)[C@H](C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](N)CCCNC(N)=N)C1=CC=CC=C1 SPSXSWRZQFPVTJ-ZQQKUFEYSA-N 0.000 description 1
- 229940124724 hepatitis-A vaccine Drugs 0.000 description 1
- 229940124736 hepatitis-B vaccine Drugs 0.000 description 1
- 229940124737 hepatitis-C vaccine Drugs 0.000 description 1
- 108091008634 hepatocyte nuclear factors 4 Proteins 0.000 description 1
- 108010052188 hepatoma-derived growth factor Proteins 0.000 description 1
- HCDGVLDPFQMKDK-UHFFFAOYSA-N hexafluoropropylene Chemical group FC(F)=C(F)C(F)(F)F HCDGVLDPFQMKDK-UHFFFAOYSA-N 0.000 description 1
- 239000004312 hexamethylene tetramine Substances 0.000 description 1
- 235000010299 hexamethylene tetramine Nutrition 0.000 description 1
- VKYKSIONXSXAKP-UHFFFAOYSA-N hexamethylenetetramine Chemical compound C1N(C2)CN3CN1CN2C3 VKYKSIONXSXAKP-UHFFFAOYSA-N 0.000 description 1
- 208000002557 hidradenitis Diseases 0.000 description 1
- 229920001519 homopolymer Polymers 0.000 description 1
- WNRQPCUGRUFHED-DETKDSODSA-N humalog Chemical compound C([C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CS)NC(=O)[C@H](CS)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(O)=O)C1=CC=C(O)C=C1.C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CS)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 WNRQPCUGRUFHED-DETKDSODSA-N 0.000 description 1
- 229940065770 humatrope Drugs 0.000 description 1
- 229940103471 humulin Drugs 0.000 description 1
- 210000004276 hyalin Anatomy 0.000 description 1
- 229960002773 hyaluronidase Drugs 0.000 description 1
- 210000004408 hybridoma Anatomy 0.000 description 1
- 229960000890 hydrocortisone Drugs 0.000 description 1
- 229960001410 hydromorphone Drugs 0.000 description 1
- UCNNJGDEJXIUCC-UHFFFAOYSA-L hydroxy(oxo)iron;iron Chemical compound [Fe].O[Fe]=O.O[Fe]=O UCNNJGDEJXIUCC-UHFFFAOYSA-L 0.000 description 1
- DQOCFCZRZOAIBN-WZHZPDAFSA-L hydroxycobalamin Chemical compound O.[Co+2].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O DQOCFCZRZOAIBN-WZHZPDAFSA-L 0.000 description 1
- 229940026037 ibandronate injection Drugs 0.000 description 1
- 229960005236 ibandronic acid Drugs 0.000 description 1
- 229960001001 ibritumomab tiuxetan Drugs 0.000 description 1
- 229940099279 idamycin Drugs 0.000 description 1
- 229950005646 imgatuzumab Drugs 0.000 description 1
- 229960002182 imipenem Drugs 0.000 description 1
- ZSKVGTPCRGIANV-ZXFLCMHBSA-N imipenem Chemical compound C1C(SCC\N=C\N)=C(C(O)=O)N2C(=O)[C@H]([C@H](O)C)[C@H]21 ZSKVGTPCRGIANV-ZXFLCMHBSA-N 0.000 description 1
- 229940127121 immunoconjugate Drugs 0.000 description 1
- 229940026063 imovax Drugs 0.000 description 1
- 230000001976 improved effect Effects 0.000 description 1
- 108010024001 incobotulinumtoxinA Proteins 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 229950011428 indatuximab ravtansine Drugs 0.000 description 1
- 229950000932 indusatumab vedotin Drugs 0.000 description 1
- 229960000598 infliximab Drugs 0.000 description 1
- 229960003971 influenza vaccine Drugs 0.000 description 1
- 239000000893 inhibin Substances 0.000 description 1
- ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 description 1
- 210000000067 inner hair cell Anatomy 0.000 description 1
- 229940095443 innohep Drugs 0.000 description 1
- 229950004101 inotuzumab ozogamicin Drugs 0.000 description 1
- 229960004717 insulin aspart Drugs 0.000 description 1
- 229960002869 insulin glargine Drugs 0.000 description 1
- 229960000696 insulin glulisine Drugs 0.000 description 1
- 229960002068 insulin lispro Drugs 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 229940047124 interferons Drugs 0.000 description 1
- 229940047122 interleukins Drugs 0.000 description 1
- 210000002570 interstitial cell Anatomy 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 229940054114 invanz Drugs 0.000 description 1
- 229940013946 invega Drugs 0.000 description 1
- 229940088976 invirase Drugs 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 229960002603 iopromide Drugs 0.000 description 1
- 229960005386 ipilimumab Drugs 0.000 description 1
- 229940001952 iprivask Drugs 0.000 description 1
- 229940097452 iron sucrose injection Drugs 0.000 description 1
- WTFXARWRTYJXII-UHFFFAOYSA-N iron(2+);iron(3+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[O-2].[Fe+2].[Fe+3].[Fe+3] WTFXARWRTYJXII-UHFFFAOYSA-N 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 229950007752 isatuximab Drugs 0.000 description 1
- 210000004153 islets of langerhan Anatomy 0.000 description 1
- 229940011083 istodax Drugs 0.000 description 1
- 229960005435 ixekizumab Drugs 0.000 description 1
- 229940025735 jevtana Drugs 0.000 description 1
- 229940063199 kenalog Drugs 0.000 description 1
- 229940065223 kepivance Drugs 0.000 description 1
- KXCLCNHUUKTANI-RBIYJLQWSA-N keratan Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@H](COS(O)(=O)=O)O[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@H](O[C@@H](O[C@H]3[C@H]([C@@H](COS(O)(=O)=O)O[C@@H](O)[C@@H]3O)O)[C@H](NC(C)=O)[C@H]2O)COS(O)(=O)=O)O[C@H](COS(O)(=O)=O)[C@@H]1O KXCLCNHUUKTANI-RBIYJLQWSA-N 0.000 description 1
- 210000003292 kidney cell Anatomy 0.000 description 1
- 210000002384 kidney collecting duct cell Anatomy 0.000 description 1
- 229940043355 kinase inhibitor Drugs 0.000 description 1
- 229940054136 kineret Drugs 0.000 description 1
- 210000004561 lacrimal apparatus Anatomy 0.000 description 1
- 239000002648 laminated material Substances 0.000 description 1
- 229950000482 lampalizumab Drugs 0.000 description 1
- 108010032674 lampalizumab Proteins 0.000 description 1
- 229950010860 laprituximab emtansine Drugs 0.000 description 1
- 229960002486 laronidase Drugs 0.000 description 1
- 239000012633 leachable Substances 0.000 description 1
- 229940047834 lemtrada Drugs 0.000 description 1
- 210000001542 lens epithelial cell Anatomy 0.000 description 1
- 229950010470 lerdelimumab Drugs 0.000 description 1
- 229940121292 leronlimab Drugs 0.000 description 1
- 210000004901 leucine-rich repeat Anatomy 0.000 description 1
- 229960001691 leucovorin Drugs 0.000 description 1
- 229940102988 levemir Drugs 0.000 description 1
- UGOZVNFCFYTPAZ-IOXYNQHNSA-N levemir Chemical compound CCCCCCCCCCCCCC(=O)NCCCC[C@@H](C(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=2N=CNC=2)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=2N=CNC=2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=2C=CC=CC=2)C(C)C)CSSC[C@@H]2NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)C(C)C)CSSC[C@H](NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC2=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H](CSSC1)C(=O)N[C@@H](CC(N)=O)C(O)=O)CC1=CC=C(O)C=C1 UGOZVNFCFYTPAZ-IOXYNQHNSA-N 0.000 description 1
- 229940080535 levocarnitine injection Drugs 0.000 description 1
- 229950008325 levothyroxine Drugs 0.000 description 1
- 210000002332 leydig cell Anatomy 0.000 description 1
- 229950004529 lifastuzumab vedotin Drugs 0.000 description 1
- 229950001237 lilotomab Drugs 0.000 description 1
- 230000002197 limbic effect Effects 0.000 description 1
- MPVGZUGXCQEXTM-UHFFFAOYSA-N linifanib Chemical compound CC1=CC=C(F)C(NC(=O)NC=2C=CC(=CC=2)C=2C=3C(N)=NNC=3C=CC=2)=C1 MPVGZUGXCQEXTM-UHFFFAOYSA-N 0.000 description 1
- 239000000865 liniment Substances 0.000 description 1
- 150000002639 lipoxins Chemical class 0.000 description 1
- 229960002701 liraglutide Drugs 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 201000007270 liver cancer Diseases 0.000 description 1
- 208000014018 liver neoplasm Diseases 0.000 description 1
- 229950000359 lokivetmab Drugs 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 229950004563 lucatumumab Drugs 0.000 description 1
- 229950008140 lulizumab pegol Drugs 0.000 description 1
- 229940091827 lumizyme Drugs 0.000 description 1
- 229950010079 lumretuzumab Drugs 0.000 description 1
- 229940087857 lupron Drugs 0.000 description 1
- 229940040129 luteinizing hormone Drugs 0.000 description 1
- 229940042470 lyme disease vaccine Drugs 0.000 description 1
- 208000003747 lymphoid leukemia Diseases 0.000 description 1
- 229940102700 m-m-r ii Drugs 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 208000002780 macular degeneration Diseases 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 229940098829 magnesium sulfate injection Drugs 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 229940124735 malaria vaccine Drugs 0.000 description 1
- 210000003794 male germ cell Anatomy 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 229940080526 mannitol injection Drugs 0.000 description 1
- 229950003135 margetuximab Drugs 0.000 description 1
- BAXLBXFAUKGCDY-UHFFFAOYSA-N mebendazole Chemical compound [CH]1C2=NC(NC(=O)OC)=NC2=CC=C1C(=O)C1=CC=CC=C1 BAXLBXFAUKGCDY-UHFFFAOYSA-N 0.000 description 1
- 229960003439 mebendazole Drugs 0.000 description 1
- 108010000594 mecasermin Proteins 0.000 description 1
- 229960001311 mecasermin Drugs 0.000 description 1
- PSGAAPLEWMOORI-PEINSRQWSA-N medroxyprogesterone acetate Chemical compound C([C@@]12C)CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2CC[C@]2(C)[C@@](OC(C)=O)(C(C)=O)CC[C@H]21 PSGAAPLEWMOORI-PEINSRQWSA-N 0.000 description 1
- 229960003987 melatonin Drugs 0.000 description 1
- DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 description 1
- SGDBTWWWUNNDEQ-LBPRGKRZSA-N melphalan Chemical compound OC(=O)[C@@H](N)CC1=CC=C(N(CCCl)CCCl)C=C1 SGDBTWWWUNNDEQ-LBPRGKRZSA-N 0.000 description 1
- 229960002514 melphalan hydrochloride Drugs 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 229940124731 meningococcal vaccine Drugs 0.000 description 1
- RETIMRUQNCDCQB-UHFFFAOYSA-N mepivacaine hydrochloride Chemical compound Cl.CN1CCCCC1C(=O)NC1=C(C)C=CC=C1C RETIMRUQNCDCQB-UHFFFAOYSA-N 0.000 description 1
- 229960005108 mepolizumab Drugs 0.000 description 1
- 210000003584 mesangial cell Anatomy 0.000 description 1
- 210000003716 mesoderm Anatomy 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 229930002897 methoprene Natural products 0.000 description 1
- 229950003442 methoprene Drugs 0.000 description 1
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 1
- 229940027990 methylene blue injection Drugs 0.000 description 1
- 229960000907 methylthioninium chloride Drugs 0.000 description 1
- 229960004503 metoclopramide Drugs 0.000 description 1
- 210000000274 microglia Anatomy 0.000 description 1
- 229960003793 midazolam Drugs 0.000 description 1
- DDLIGBOFAVUZHB-UHFFFAOYSA-N midazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NC=C2CN=C1C1=CC=CC=C1F DDLIGBOFAVUZHB-UHFFFAOYSA-N 0.000 description 1
- 229940034688 midazolam injection Drugs 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- TZRFSLHOCZEXCC-HIVFKXHNSA-A mipomersen Chemical compound N1([C@H]2C[C@@H]([C@H](O2)COP([O-])(=O)S[C@@H]2[C@H](O[C@H](C2)N2C3=C(C(NC(N)=N3)=O)N=C2)COP([O-])(=O)S[C@@H]2[C@H](O[C@H](C2)N2C(NC(=O)C(C)=C2)=O)COP([O-])(=O)S[C@@H]2[C@H](O[C@H](C2)N2C(N=C(N)C(C)=C2)=O)COP([O-])(=O)S[C@@H]2[C@H](O[C@H](C2)N2C(NC(=O)C(C)=C2)=O)COP([O-])(=O)S[C@@H]2[C@H](O[C@H](C2)N2C3=C(C(NC(N)=N3)=O)N=C2)COP([O-])(=O)S[C@@H]2[C@H](O[C@H](C2)N2C3=NC=NC(N)=C3N=C2)COP([O-])(=O)S[C@H]2[C@H]([C@@H](O[C@@H]2COP([O-])(=O)S[C@H]2[C@H]([C@@H](O[C@@H]2COP([O-])(=O)S[C@H]2[C@H]([C@@H](O[C@@H]2COP([O-])(=O)S[C@H]2[C@H]([C@@H](O[C@@H]2COP([O-])(=O)S[C@H]2[C@H]([C@@H](O[C@@H]2CO)N2C3=C(C(NC(N)=N3)=O)N=C2)OCCOC)N2C(N=C(N)C(C)=C2)=O)OCCOC)N2C(N=C(N)C(C)=C2)=O)OCCOC)N2C(NC(=O)C(C)=C2)=O)OCCOC)N2C(N=C(N)C(C)=C2)=O)OCCOC)SP([O-])(=O)OC[C@H]2O[C@H](C[C@@H]2SP([O-])(=O)OC[C@H]2O[C@H](C[C@@H]2SP([O-])(=O)OC[C@H]2O[C@H](C[C@@H]2SP([O-])(=O)OC[C@@H]2[C@H]([C@H]([C@@H](O2)N2C3=C(C(NC(N)=N3)=O)N=C2)OCCOC)SP([O-])(=O)OC[C@H]2[C@@H]([C@@H]([C@H](O2)N2C(N=C(N)C(C)=C2)=O)OCCOC)SP([O-])(=O)OC[C@H]2[C@@H]([C@@H]([C@H](O2)N2C3=NC=NC(N)=C3N=C2)OCCOC)SP([O-])(=O)OC[C@H]2[C@@H]([C@@H]([C@H](O2)N2C(N=C(N)C(C)=C2)=O)OCCOC)SP([O-])(=O)OC[C@H]2[C@H](O)[C@@H]([C@H](O2)N2C(N=C(N)C(C)=C2)=O)OCCOC)N2C(N=C(N)C(C)=C2)=O)N2C(NC(=O)C(C)=C2)=O)N2C(NC(=O)C(C)=C2)=O)C=C(C)C(N)=NC1=O TZRFSLHOCZEXCC-HIVFKXHNSA-A 0.000 description 1
- 229960004778 mipomersen Drugs 0.000 description 1
- 108091060283 mipomersen Proteins 0.000 description 1
- 229950000035 mirvetuximab soravtansine Drugs 0.000 description 1
- 239000003226 mitogen Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 229950005674 modotuximab Drugs 0.000 description 1
- 229950001907 monalizumab Drugs 0.000 description 1
- 210000001616 monocyte Anatomy 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 229950000720 moxetumomab pasudotox Drugs 0.000 description 1
- 229940103023 myozyme Drugs 0.000 description 1
- LZVVYYJRTRDVNF-JFGBDZIUSA-N n,n'-dibenzylethane-1,2-diamine;2-(diethylamino)ethyl 4-aminobenzoate;(2s,5r,6r)-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1.C=1C=CC=CC=1CNCCNCC1=CC=CC=C1.N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1.N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1.N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 LZVVYYJRTRDVNF-JFGBDZIUSA-N 0.000 description 1
- ZESIAEVDVPWEKB-ORCFLVBFSA-N n-[(2s)-4-amino-1-[[(2s,3r)-1-[[(2s)-4-amino-1-oxo-1-[[(3s,6s,9s,12s,15r,18s,21s)-6,9,18-tris(2-aminoethyl)-3-[(1r)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-h Chemical compound OS(O)(=O)=O.OS(O)(=O)=O.CC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O ZESIAEVDVPWEKB-ORCFLVBFSA-N 0.000 description 1
- YUTIXVXZQIQWGY-UHFFFAOYSA-N n-[4-[6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]oxy-1,3-benzothiazol-2-yl]acetamide Chemical compound C1=CC=C2SC(NC(=O)C)=NC2=C1OC(N=CN=1)=CC=1C1=CC=C(C(F)(F)F)C=C1 YUTIXVXZQIQWGY-UHFFFAOYSA-N 0.000 description 1
- 229950003027 nacolomab tafenatox Drugs 0.000 description 1
- 210000000282 nail Anatomy 0.000 description 1
- 229960003086 naltrexone Drugs 0.000 description 1
- 229960001935 nandrolone decanoate Drugs 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 229950009793 naptumomab estafenatox Drugs 0.000 description 1
- 229950001422 naratuximab emtansine Drugs 0.000 description 1
- 229950008353 narnatumab Drugs 0.000 description 1
- 229960005027 natalizumab Drugs 0.000 description 1
- 210000000581 natural killer T-cell Anatomy 0.000 description 1
- 210000000822 natural killer cell Anatomy 0.000 description 1
- 229950004847 navitoclax Drugs 0.000 description 1
- JLYAXFNOILIKPP-KXQOOQHDSA-N navitoclax Chemical compound C([C@@H](NC1=CC=C(C=C1S(=O)(=O)C(F)(F)F)S(=O)(=O)NC(=O)C1=CC=C(C=C1)N1CCN(CC1)CC1=C(CCC(C1)(C)C)C=1C=CC(Cl)=CC=1)CSC=1C=CC=CC=1)CN1CCOCC1 JLYAXFNOILIKPP-KXQOOQHDSA-N 0.000 description 1
- 229950010591 navivumab Drugs 0.000 description 1
- 229950010012 nemolizumab Drugs 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 229950002697 nesvacumab Drugs 0.000 description 1
- 229940071846 neulasta Drugs 0.000 description 1
- 108010089579 neuropeptide Y2 receptor Proteins 0.000 description 1
- 230000000508 neurotrophic effect Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229940063708 neutrexin Drugs 0.000 description 1
- 210000000440 neutrophil Anatomy 0.000 description 1
- 229940057462 nexterone Drugs 0.000 description 1
- 229950010203 nimotuzumab Drugs 0.000 description 1
- 150000002825 nitriles Chemical class 0.000 description 1
- 108010020615 nociceptin receptor Proteins 0.000 description 1
- 102000037979 non-receptor tyrosine kinases Human genes 0.000 description 1
- 108091008046 non-receptor tyrosine kinases Proteins 0.000 description 1
- 230000000263 nonmitogenic effect Effects 0.000 description 1
- 229940063137 norditropin Drugs 0.000 description 1
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 description 1
- 229940112879 novolog Drugs 0.000 description 1
- URPYMXQQVHTUDU-OFGSCBOVSA-N nucleopeptide y Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 URPYMXQQVHTUDU-OFGSCBOVSA-N 0.000 description 1
- 108010028794 nucleoprotein kinase Proteins 0.000 description 1
- 210000004940 nucleus Anatomy 0.000 description 1
- 229940063149 nutropin Drugs 0.000 description 1
- 208000003177 ocular onchocerciasis Diseases 0.000 description 1
- 210000004416 odontoblast Anatomy 0.000 description 1
- 210000002560 odontocyte Anatomy 0.000 description 1
- 229950010465 odulimomab Drugs 0.000 description 1
- 229960002450 ofatumumab Drugs 0.000 description 1
- 229960005017 olanzapine Drugs 0.000 description 1
- 229950008516 olaratumab Drugs 0.000 description 1
- 210000001517 olfactory receptor neuron Anatomy 0.000 description 1
- 210000004248 oligodendroglia Anatomy 0.000 description 1
- 229950010006 olokizumab Drugs 0.000 description 1
- 230000000174 oncolytic effect Effects 0.000 description 1
- 102000027450 oncoproteins Human genes 0.000 description 1
- 108091008819 oncoproteins Proteins 0.000 description 1
- 229960000770 ondansetron hydrochloride Drugs 0.000 description 1
- 210000000287 oocyte Anatomy 0.000 description 1
- 229950009057 oportuzumab monatox Drugs 0.000 description 1
- 229940035567 orencia Drugs 0.000 description 1
- 229960003104 ornithine Drugs 0.000 description 1
- 230000003534 oscillatory effect Effects 0.000 description 1
- 210000000963 osteoblast Anatomy 0.000 description 1
- 210000002997 osteoclast Anatomy 0.000 description 1
- 210000002488 outer root sheath cell Anatomy 0.000 description 1
- 230000002611 ovarian Effects 0.000 description 1
- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 description 1
- 229960001756 oxaliplatin Drugs 0.000 description 1
- 229940104914 oxaliplatin injection Drugs 0.000 description 1
- 230000036542 oxidative stress Effects 0.000 description 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 description 1
- 229950009723 ozanezumab Drugs 0.000 description 1
- BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 description 1
- 102000022032 p53 binding proteins Human genes 0.000 description 1
- 108091012362 p53 binding proteins Proteins 0.000 description 1
- 229960003978 pamidronic acid Drugs 0.000 description 1
- 229950003481 pamrevlumab Drugs 0.000 description 1
- 210000000277 pancreatic duct Anatomy 0.000 description 1
- 108091005474 pancreatic polypeptide receptors Proteins 0.000 description 1
- 229950003570 panobacumab Drugs 0.000 description 1
- 229960002566 papillomavirus vaccine Drugs 0.000 description 1
- 230000000849 parathyroid Effects 0.000 description 1
- 229960001319 parathyroid hormone Drugs 0.000 description 1
- 239000000199 parathyroid hormone Substances 0.000 description 1
- 229940105640 paricalcitol injection Drugs 0.000 description 1
- 235000011837 pasties Nutrition 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 108010044644 pegfilgrastim Proteins 0.000 description 1
- 229950011098 pendetide Drugs 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 235000019371 penicillin G benzathine Nutrition 0.000 description 1
- IQWHCHZFYPIVRV-UHFFFAOYSA-I pentasodium;[2-[17-(1-hydroxyethyl)-22-[[2-[[3-hydroxy-2-[[2-(6-methyloctanoylamino)-4-(sulfonatomethylamino)butanoyl]amino]butanoyl]amino]-4-(sulfonatomethylamino)butanoyl]amino]-5,8-bis(2-methylpropyl)-3,6,9,12,15,18,23-heptaoxo-11,14-bis[2-(sulfonatome Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].CCC(C)CCCCC(=O)NC(CCNCS([O-])(=O)=O)C(=O)NC(C(C)O)C(=O)NC(CCNCS([O-])(=O)=O)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCNCS([O-])(=O)=O)NC(=O)C(CCNCS([O-])(=O)=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCNCS([O-])(=O)=O)NC1=O IQWHCHZFYPIVRV-UHFFFAOYSA-I 0.000 description 1
- 229960001999 phentolamine Drugs 0.000 description 1
- 108010055752 phenylalanyl-leucyl-phenylalanyl-glutaminyl-prolyl-glutaminyl-arginyl-phenylalaninamide Proteins 0.000 description 1
- 150000003906 phosphoinositides Chemical class 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 238000006366 phosphorylation reaction Methods 0.000 description 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 229950010074 pinatuzumab vedotin Drugs 0.000 description 1
- 230000001817 pituitary effect Effects 0.000 description 1
- 102000030769 platelet activating factor receptor Human genes 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 229940031960 pneumococcal polysaccharide vaccine Drugs 0.000 description 1
- 229940049548 pneumovax Drugs 0.000 description 1
- 229950009416 polatuzumab vedotin Drugs 0.000 description 1
- ONJQDTZCDSESIW-UHFFFAOYSA-N polidocanol Chemical compound CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO ONJQDTZCDSESIW-UHFFFAOYSA-N 0.000 description 1
- 229960001539 poliomyelitis vaccine Drugs 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 229920000747 poly(lactic acid) Polymers 0.000 description 1
- 229920002492 poly(sulfone) Polymers 0.000 description 1
- 229920006393 polyether sulfone Polymers 0.000 description 1
- 229920001721 polyimide Polymers 0.000 description 1
- 239000004626 polylactic acid Substances 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 229950003486 ponezumab Drugs 0.000 description 1
- ABVRVIZBZKUTMK-JSYANWSFSA-M potassium clavulanate Chemical compound [K+].[O-]C(=O)[C@H]1C(=C/CO)/O[C@@H]2CC(=O)N21 ABVRVIZBZKUTMK-JSYANWSFSA-M 0.000 description 1
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 description 1
- FASDKYOPVNHBLU-ZETCQYMHSA-N pramipexole Chemical compound C1[C@@H](NCCC)CCC2=C1SC(N)=N2 FASDKYOPVNHBLU-ZETCQYMHSA-N 0.000 description 1
- 229960003089 pramipexole Drugs 0.000 description 1
- 229960004457 pramlintide acetate Drugs 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 229940063238 premarin Drugs 0.000 description 1
- 229940126623 prezalizumab Drugs 0.000 description 1
- 229950003700 priliximab Drugs 0.000 description 1
- 229950009904 pritumumab Drugs 0.000 description 1
- 229940029359 procrit Drugs 0.000 description 1
- 239000000583 progesterone congener Substances 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 229960003910 promethazine Drugs 0.000 description 1
- OLBCVFGFOZPWHH-UHFFFAOYSA-N propofol Chemical compound CC(C)C1=CC=CC(C(C)C)=C1O OLBCVFGFOZPWHH-UHFFFAOYSA-N 0.000 description 1
- 229960004134 propofol Drugs 0.000 description 1
- 230000000272 proprioceptive effect Effects 0.000 description 1
- 229940127293 prostanoid Drugs 0.000 description 1
- 150000003814 prostanoids Chemical class 0.000 description 1
- 229940030749 prostate cancer vaccine Drugs 0.000 description 1
- 210000005267 prostate cell Anatomy 0.000 description 1
- 229960000856 protein c Drugs 0.000 description 1
- 108010061269 protein kinase D Proteins 0.000 description 1
- 108010061151 protein kinase N Proteins 0.000 description 1
- 229940039716 prothrombin Drugs 0.000 description 1
- XNSAINXGIQZQOO-SRVKXCTJSA-N protirelin Chemical compound NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H]1NC(=O)CC1)CC1=CN=CN1 XNSAINXGIQZQOO-SRVKXCTJSA-N 0.000 description 1
- 229940063222 provera Drugs 0.000 description 1
- 210000000512 proximal kidney tubule Anatomy 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 229940037230 quadracel Drugs 0.000 description 1
- 229950003033 quilizumab Drugs 0.000 description 1
- 229960001811 quinine hydrochloride Drugs 0.000 description 1
- 229960003127 rabies vaccine Drugs 0.000 description 1
- 229950011613 racotumomab Drugs 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 229910052704 radon Inorganic materials 0.000 description 1
- SYUHGPGVQRZVTB-UHFFFAOYSA-N radon atom Chemical compound [Rn] SYUHGPGVQRZVTB-UHFFFAOYSA-N 0.000 description 1
- 229960002633 ramucirumab Drugs 0.000 description 1
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 description 1
- 229960004910 raxibacumab Drugs 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 102000027426 receptor tyrosine kinases Human genes 0.000 description 1
- 108091008598 receptor tyrosine kinases Proteins 0.000 description 1
- 229940107023 reclast Drugs 0.000 description 1
- 229950000987 refanezumab Drugs 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 229950005854 regavirumab Drugs 0.000 description 1
- 229940080693 reglan Drugs 0.000 description 1
- 229940116176 remicade Drugs 0.000 description 1
- 238000007634 remodeling Methods 0.000 description 1
- 229940020428 renagel Drugs 0.000 description 1
- 229940047681 renvela Drugs 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 229960003254 reslizumab Drugs 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 230000003307 reticuloendothelial effect Effects 0.000 description 1
- 102000027483 retinoid hormone receptors Human genes 0.000 description 1
- 108091008679 retinoid hormone receptors Proteins 0.000 description 1
- 238000009420 retrofitting Methods 0.000 description 1
- 229940064914 retrovir Drugs 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 229950005978 rinucumab Drugs 0.000 description 1
- 229950004441 rivabazumab pegol Drugs 0.000 description 1
- 229960003452 romidepsin Drugs 0.000 description 1
- 229950006765 rovalpituzumab tesirine Drugs 0.000 description 1
- 229950005374 ruplizumab Drugs 0.000 description 1
- 229950000143 sacituzumab govitecan Drugs 0.000 description 1
- ULRUOUDIQPERIJ-PQURJYPBSA-N sacituzumab govitecan Chemical compound N([C@@H](CCCCN)C(=O)NC1=CC=C(C=C1)COC(=O)O[C@]1(CC)C(=O)OCC2=C1C=C1N(C2=O)CC2=C(C3=CC(O)=CC=C3N=C21)CC)C(=O)COCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCN(N=N1)C=C1CNC(=O)C(CC1)CCC1CN1C(=O)CC(SC[C@H](N)C(O)=O)C1=O ULRUOUDIQPERIJ-PQURJYPBSA-N 0.000 description 1
- 229960003542 saquinavir mesylate Drugs 0.000 description 1
- 108010038379 sargramostim Proteins 0.000 description 1
- 229950006348 sarilumab Drugs 0.000 description 1
- 229950007308 satumomab Drugs 0.000 description 1
- 201000004409 schistosomiasis Diseases 0.000 description 1
- 210000004116 schwann cell Anatomy 0.000 description 1
- 210000001732 sebaceous gland Anatomy 0.000 description 1
- 229960002101 secretin Drugs 0.000 description 1
- OWMZNFCDEHGFEP-NFBCVYDUSA-N secretin human Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(N)=O)[C@@H](C)O)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)C1=CC=CC=C1 OWMZNFCDEHGFEP-NFBCVYDUSA-N 0.000 description 1
- 108700027603 secretin receptor Proteins 0.000 description 1
- 210000001625 seminal vesicle Anatomy 0.000 description 1
- 229960003693 sevelamer Drugs 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 229950009513 simtuzumab Drugs 0.000 description 1
- 229940115586 simulect Drugs 0.000 description 1
- 229950003804 siplizumab Drugs 0.000 description 1
- 229960002930 sirolimus Drugs 0.000 description 1
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 description 1
- 229950006094 sirukumab Drugs 0.000 description 1
- 210000002363 skeletal muscle cell Anatomy 0.000 description 1
- 101150117832 slc24a5 gene Proteins 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 229940083538 smallpox vaccine Drugs 0.000 description 1
- 210000001057 smooth muscle myoblast Anatomy 0.000 description 1
- 210000000329 smooth muscle myocyte Anatomy 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- JWBPVFVNISJVEM-UHFFFAOYSA-M sodium caffeine benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1.CN1C(=O)N(C)C(=O)C2=C1N=CN2C JWBPVFVNISJVEM-UHFFFAOYSA-M 0.000 description 1
- 239000008354 sodium chloride injection Substances 0.000 description 1
- 229940074404 sodium succinate Drugs 0.000 description 1
- ZDQYSKICYIVCPN-UHFFFAOYSA-L sodium succinate (anhydrous) Chemical compound [Na+].[Na+].[O-]C(=O)CCC([O-])=O ZDQYSKICYIVCPN-UHFFFAOYSA-L 0.000 description 1
- JJICLMJFIKGAAU-UHFFFAOYSA-M sodium;2-amino-9-(1,3-dihydroxypropan-2-yloxymethyl)purin-6-olate Chemical compound [Na+].NC1=NC([O-])=C2N=CN(COC(CO)CO)C2=N1 JJICLMJFIKGAAU-UHFFFAOYSA-M 0.000 description 1
- PCNRQYHSJVEIGH-ASTDGNLGSA-M sodium;5-benzo[e]benzotriazol-2-yl-2-[(e)-2-phenylethenyl]benzenesulfonate Chemical compound [Na+].[O-]S(=O)(=O)C1=CC(N2N=C3C4=CC=CC=C4C=CC3=N2)=CC=C1\C=C\C1=CC=CC=C1 PCNRQYHSJVEIGH-ASTDGNLGSA-M 0.000 description 1
- MQRFYYBWKRACSJ-UHFFFAOYSA-N sodium;[2-(9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl)-2-oxoethyl] dihydrogen phosphate Chemical compound [Na+].C1CC2=CC(=O)C=CC2(C)C2(F)C1C1CC(C)C(C(=O)COP(O)(O)=O)(O)C1(C)CC2O MQRFYYBWKRACSJ-UHFFFAOYSA-N 0.000 description 1
- OTNVGWMVOULBFZ-UHFFFAOYSA-N sodium;hydrochloride Chemical compound [Na].Cl OTNVGWMVOULBFZ-UHFFFAOYSA-N 0.000 description 1
- MHQHHBYRYFICDV-UHFFFAOYSA-M sodium;pyrimidin-3-ide-2,4,6-trione Chemical compound [Na+].O=C1CC(=O)[N-]C(=O)N1 MHQHHBYRYFICDV-UHFFFAOYSA-M 0.000 description 1
- 229950003763 sofituzumab vedotin Drugs 0.000 description 1
- 229940055944 soliris Drugs 0.000 description 1
- 229950006551 sontuzumab Drugs 0.000 description 1
- 229950002549 stamulumab Drugs 0.000 description 1
- 229940071598 stelara Drugs 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 210000000352 storage cell Anatomy 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 description 1
- 239000011115 styrene butadiene Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- VLYWMPOKSSWJAL-UHFFFAOYSA-N sulfamethoxypyridazine Chemical compound N1=NC(OC)=CC=C1NS(=O)(=O)C1=CC=C(N)C=C1 VLYWMPOKSSWJAL-UHFFFAOYSA-N 0.000 description 1
- IHBMMJGTJFPEQY-UHFFFAOYSA-N sulfanylidene(sulfanylidenestibanylsulfanyl)stibane Chemical compound S=[Sb]S[Sb]=S IHBMMJGTJFPEQY-UHFFFAOYSA-N 0.000 description 1
- PORMUFZNYQJOEI-UHFFFAOYSA-N sumatriptan succinate Chemical compound OC(=O)CCC(O)=O.CNS(=O)(=O)CC1=CC=C2NC=C(CCN(C)C)C2=C1 PORMUFZNYQJOEI-UHFFFAOYSA-N 0.000 description 1
- 229940076556 sumavel Drugs 0.000 description 1
- 238000004381 surface treatment Methods 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 229950001915 suvizumab Drugs 0.000 description 1
- 229940099093 symlin Drugs 0.000 description 1
- 229940036185 synagis Drugs 0.000 description 1
- 229920003051 synthetic elastomer Polymers 0.000 description 1
- 239000005061 synthetic rubber Substances 0.000 description 1
- 208000006379 syphilis Diseases 0.000 description 1
- 229950010265 tabalumab Drugs 0.000 description 1
- 229950008461 talimogene laherparepvec Drugs 0.000 description 1
- 229950004218 talizumab Drugs 0.000 description 1
- 229950001603 taplitumomab paptox Drugs 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 210000001779 taste bud Anatomy 0.000 description 1
- 210000000108 taste bud cell Anatomy 0.000 description 1
- 229950000864 technetium (99mtc) nofetumomab merpentan Drugs 0.000 description 1
- ONUMZHGUFYIKPM-MXNFEBESSA-N telavancin Chemical compound O1[C@@H](C)[C@@H](O)[C@](NCCNCCCCCCCCCC)(C)C[C@@H]1O[C@H]1[C@H](OC=2C3=CC=4[C@H](C(N[C@H]5C(=O)N[C@H](C(N[C@@H](C6=CC(O)=C(CNCP(O)(O)=O)C(O)=C6C=6C(O)=CC=C5C=6)C(O)=O)=O)[C@H](O)C5=CC=C(C(=C5)Cl)O3)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](NC(=O)[C@@H](CC(C)C)NC)[C@H](O)C3=CC=C(C(=C3)Cl)OC=2C=4)O[C@H](CO)[C@@H](O)[C@@H]1O ONUMZHGUFYIKPM-MXNFEBESSA-N 0.000 description 1
- 229960005240 telavancin Drugs 0.000 description 1
- GSSIWSIRBWAZHG-ACOPVEIWSA-N telavancin hydrochloride Chemical compound Cl.O1[C@@H](C)[C@@H](O)[C@](NCCNCCCCCCCCCC)(C)C[C@@H]1O[C@H]1[C@H](OC=2C3=CC=4[C@H](C(N[C@H]5C(=O)N[C@H](C(N[C@@H](C6=CC(O)=C(CNCP(O)(O)=O)C(O)=C6C=6C(O)=CC=C5C=6)C(O)=O)=O)[C@H](O)C5=CC=C(C(=C5)Cl)O3)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](NC(=O)[C@@H](CC(C)C)NC)[C@H](O)C3=CC=C(C(=C3)Cl)OC=2C=4)O[C@H](CO)[C@@H](O)[C@@H]1O GSSIWSIRBWAZHG-ACOPVEIWSA-N 0.000 description 1
- 229950008300 telimomab aritox Drugs 0.000 description 1
- 229960000235 temsirolimus Drugs 0.000 description 1
- QFJCIRLUMZQUOT-UHFFFAOYSA-N temsirolimus Natural products C1CC(O)C(OC)CC1CC(C)C1OC(=O)C2CCCCN2C(=O)C(=O)C(O)(O2)C(C)CCC2CC(OC)C(C)=CC=CC=CC(C)CC(C)C(=O)C(OC)C(O)C(C)=CC(C)C(=O)C1 QFJCIRLUMZQUOT-UHFFFAOYSA-N 0.000 description 1
- 229940011901 temsirolimus injection Drugs 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 229960000216 tenecteplase Drugs 0.000 description 1
- 229960005460 teriparatide Drugs 0.000 description 1
- JCQBWMAWTUBARI-UHFFFAOYSA-N tert-butyl 3-ethenylpiperidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCCC(C=C)C1 JCQBWMAWTUBARI-UHFFFAOYSA-N 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 239000012815 thermoplastic material Substances 0.000 description 1
- 208000008732 thymoma Diseases 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 102000004217 thyroid hormone receptors Human genes 0.000 description 1
- 108090000721 thyroid hormone receptors Proteins 0.000 description 1
- 229940034199 thyrotropin-releasing hormone Drugs 0.000 description 1
- 229940034208 thyroxine Drugs 0.000 description 1
- 229960004659 ticarcillin Drugs 0.000 description 1
- ZBBCUBMBMZNEME-QBGWIPKPSA-L ticarcillin disodium Chemical compound [Na+].[Na+].C=1([C@@H](C([O-])=O)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C([O-])=O)(C)C)C=CSC=1 ZBBCUBMBMZNEME-QBGWIPKPSA-L 0.000 description 1
- 229940111100 tice bcg Drugs 0.000 description 1
- 229950004742 tigatuzumab Drugs 0.000 description 1
- 229950005515 tildrakizumab Drugs 0.000 description 1
- SYRHIZPPCHMRIT-UHFFFAOYSA-N tin(4+) Chemical compound [Sn+4] SYRHIZPPCHMRIT-UHFFFAOYSA-N 0.000 description 1
- 229950004269 tisotumab vedotin Drugs 0.000 description 1
- 229940113038 tnkase Drugs 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 235000019149 tocopherols Nutrition 0.000 description 1
- 210000004906 toe nail Anatomy 0.000 description 1
- CRDAMVZIKSXKFV-UHFFFAOYSA-N trans-Farnesol Natural products CC(C)=CCCC(C)=CCCC(C)=CCO CRDAMVZIKSXKFV-UHFFFAOYSA-N 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 108091006108 transcriptional coactivators Proteins 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 108010075758 trebananib Proteins 0.000 description 1
- 229950010086 tregalizumab Drugs 0.000 description 1
- 229950007217 tremelimumab Drugs 0.000 description 1
- 229960005294 triamcinolone Drugs 0.000 description 1
- 229960004320 triamcinolone diacetate Drugs 0.000 description 1
- 229940038017 triesence Drugs 0.000 description 1
- 229960004824 triptorelin Drugs 0.000 description 1
- 229960000294 triptorelin pamoate Drugs 0.000 description 1
- 229940086984 trisenox Drugs 0.000 description 1
- 229940035144 trumenba Drugs 0.000 description 1
- 201000002311 trypanosomiasis Diseases 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- 210000005239 tubule Anatomy 0.000 description 1
- 229950003364 tucotuzumab celmoleukin Drugs 0.000 description 1
- 108700008509 tucotuzumab celmoleukin Proteins 0.000 description 1
- 229950005082 tuvirumab Drugs 0.000 description 1
- 229960004059 tylosin Drugs 0.000 description 1
- WBPYTXDJUQJLPQ-VMXQISHHSA-N tylosin Chemical compound O([C@@H]1[C@@H](C)O[C@H]([C@@H]([C@H]1N(C)C)O)O[C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CC=O)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@H]1C[C@@](C)(O)[C@@H](O)[C@H](C)O1 WBPYTXDJUQJLPQ-VMXQISHHSA-N 0.000 description 1
- 235000019375 tylosin Nutrition 0.000 description 1
- 201000008297 typhoid fever Diseases 0.000 description 1
- 229950004593 ublituximab Drugs 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 229950005972 urelumab Drugs 0.000 description 1
- 210000003708 urethra Anatomy 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
- 229960005356 urokinase Drugs 0.000 description 1
- 229950004362 urtoxazumab Drugs 0.000 description 1
- 229950003520 utomilumab Drugs 0.000 description 1
- 229950001694 vadastuximab talirine Drugs 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
- HABDXNKVAIZXKJ-XTTLPDOESA-N vancocin sulfate Chemical compound OS(O)(=O)=O.O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 HABDXNKVAIZXKJ-XTTLPDOESA-N 0.000 description 1
- 229950001876 vandortuzumab vedotin Drugs 0.000 description 1
- 229940054353 vaprisol Drugs 0.000 description 1
- 229940021648 varicella vaccine Drugs 0.000 description 1
- 229960003726 vasopressin Drugs 0.000 description 1
- 229950000815 veltuzumab Drugs 0.000 description 1
- 229950005208 vepalimomab Drugs 0.000 description 1
- 229960003895 verteporfin Drugs 0.000 description 1
- 201000010653 vesiculitis Diseases 0.000 description 1
- 229940020733 vibativ Drugs 0.000 description 1
- 229940007428 victoza Drugs 0.000 description 1
- 201000002498 viral encephalitis Diseases 0.000 description 1
- 229950004393 visilizumab Drugs 0.000 description 1
- 229940061392 visudyne Drugs 0.000 description 1
- 102000009310 vitamin D receptors Human genes 0.000 description 1
- 108050000156 vitamin D receptors Proteins 0.000 description 1
- 210000004127 vitreous body Anatomy 0.000 description 1
- 229940057739 vivitrol Drugs 0.000 description 1
- 229950007269 vobarilizumab Drugs 0.000 description 1
- 229950001212 volociximab Drugs 0.000 description 1
- 229950003511 votumumab Drugs 0.000 description 1
- 229940018272 xeomin Drugs 0.000 description 1
- 229960001515 yellow fever vaccine Drugs 0.000 description 1
- 229950004899 yttrium (90y) tacatuzumab tetraxetan Drugs 0.000 description 1
- GRTBAGCGDOYUBE-OUBTZVSYSA-N yttrium-90(3+) Chemical compound [90Y+3] GRTBAGCGDOYUBE-OUBTZVSYSA-N 0.000 description 1
- 229950009002 zanolimumab Drugs 0.000 description 1
- 229940108322 zantac Drugs 0.000 description 1
- 229940052212 zemplar Drugs 0.000 description 1
- 229960002555 zidovudine Drugs 0.000 description 1
- 229940049909 zingo Drugs 0.000 description 1
- DUBNHZYBDBBJHD-UHFFFAOYSA-L ziram Chemical compound [Zn+2].CN(C)C([S-])=S.CN(C)C([S-])=S DUBNHZYBDBBJHD-UHFFFAOYSA-L 0.000 description 1
- 229950007157 zolbetuximab Drugs 0.000 description 1
- 229940002005 zometa Drugs 0.000 description 1
- 229940107931 zovirax Drugs 0.000 description 1
- 229940039925 zyprexa Drugs 0.000 description 1
- QUEDXNHFTDJVIY-UHFFFAOYSA-N γ-tocopherol Chemical class OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
- A61M5/31513—Piston constructions to improve sealing or sliding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3129—Syringe barrels
- A61M2005/3131—Syringe barrels specially adapted for improving sealing or sliding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
- A61M2205/0222—Materials for reducing friction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
- A61M2205/0238—General characteristics of the apparatus characterised by a particular materials the material being a coating or protective layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2207/00—Methods of manufacture, assembly or production
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2207/00—Methods of manufacture, assembly or production
- A61M2207/10—Device therefor
Landscapes
- Health & Medical Sciences (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Fuel-Injection Apparatus (AREA)
Abstract
用于制造注入器装置的方法包括将注入器装置的止挡件定位在管状构件中,使得止挡件的外侧与管状构件的内表面接合;以及通过引起止挡件和管状构件之间的相对运动来修改止挡件的外侧,该相对运动包括旋转运动和振动运动中的一者或两者。
Description
技术领域
本说明书中提出的各种发明构思涉及包括针筒和可滑动地接纳在针筒中的止挡件的注入器装置,诸如注射器、自动注入器和笔,以及制造和使用这种装置的相关方法。
背景技术
注入器装置(例如,注射器、自动注入器和笔)通常包括针筒、定位在针筒内的止挡件、以及用于使止挡件移位的柱塞杆或致动机构。该止挡件通常是不可渗透空气和液体的,同时还具有低摩擦滑动性。空气不可渗透性和液体不可渗透性对于消除在将液体充注到注入器装置内部或从注入器装置内部排出液体时针筒内的液体泄漏、以及在止挡件的外表面与针筒的内壁之间引入空气是重要的。低摩擦滑动性对于促进注入器装置内部的液体的充注和排出是重要的。除了这些要求之外,医用注射器、自动注入器或笔不应对任何药物组合物产生不利影响,诸如与注射器接触的生物药物(例如,包括药物组合物的预填充注射器、自动注入器或笔)。
注入器装置部件的一些示例可以在申请人W.L.戈尔及同仁公司(W.L.Gore&Associates,Inc.)提交的题为“具有低润滑剂疏水性注射器针筒的医疗注入器装置(Medical Injector devices Having Low Lubricant Hydrophobic Syringe Barrels)”的美国公开2021/0030970中找到,其描述了医疗注入器装置。该医疗注入器装置包括针筒和止挡件,止挡件可以提供空气和液体不可渗透性,同时还具有低摆脱力(breake looseforce)、低平均滑动力和低滑动力变化中的一个或多个。
注入器装置部件的更多示例可以在申请人住友橡胶工业有限公司(SumitomoRubber Industries,Ltd.)的题为“垫圈和医用注射器(Gasket,and Medical Syringe)”的美国专利10,751,473中找到,该专利描述了用于医用注射器的垫圈,该垫圈包括由弹性材料制成的本体和设置在本体表面上的惰性树脂薄膜。垫圈具有圆筒形状,并且包括设置在其外周表面上的环形肋部,每个环形肋部具有与注射器针筒的内周表面保持滑动接触的滑动接触部分。环形肋部从垫圈的远端到后端轴向地设置。远侧环形肋部的滑动接触部分的宽度为圆筒形垫圈的轴向长度的1%至25%。
发明内容
对于包括屏障或屏障层并且不使用硅酮或其他附加润滑材料(例如液体润滑剂)来填充屏障中的缺陷的任何止挡件来说,形成耐用密封可能是困难的。这些缺陷可能是由于插入过程中止挡件受压而在屏障中形成的褶皱、止挡件制造或插入过程中密封区域表面上出现的划痕、或部件制造和组装过程中产生的其他缺陷引起的。通常,直到将止挡件插入针筒中后,缺陷才产生或变得明显。因此,在将止挡件插入到针筒中之前不可能预防、消除或处理各种缺陷。本说明书中阐述的各种发明构思涉及在止挡件已经通过相关联的插入过程到针筒中期间或之后处理此类缺陷或改善密封性能。
根据一些示例,一种用于制造注入器装置的方法包括将注入器装置的止挡件定位在管状构件中,使得止挡件的外侧与管状构件的内表面接合;以及通过引起止挡件和管状构件之间的相对运动来修改止挡件的外侧,该相对运动包括旋转运动和振动运动中的一者或两者。管状构件可以是注入器装置的针筒、构造成插入到注入器装置的针筒中的通气管、构造成将止挡件递送到注入器装置的针筒中的通气管、或另一管状构件。止挡件的外侧可选地限定肋部,并且止挡件和管状构件之间的相对运动导致肋部处的局部加热。在一些示例中,相对运动导致止挡件的外侧的粗糙度减小。止挡件的外侧可包括褶皱,并且相对运动可能导致褶皱减少。止挡件的外侧可限定沿纵向方向和周向方向的粗糙度,并且相对运动可导致沿纵向方向和/或周向方向的粗糙度的减小。相对运动可导致材料从止挡件的外侧转移至管状构件的内表面。止挡件的外侧可选地包括聚合物材料,并且相对运动引发聚合物材料的聚合物运动。止挡件可以包括由第一材料形成的屏障和由第二材料形成的本体,屏障联接至本体。并且,止挡件的外侧可以包括含氟聚合物材料。在一些示例中,止挡件和管状构件之间的相对运动包括纵向分量。
根据一些示例,用于制造注入器装置的方法包括将注入器装置的止挡件定位在通气管中;将通气管插入到注入器装置的针筒中;将止挡件从通气管递送到注入器装置的针筒中,使得止挡件的外侧与针筒的内表面接合,以在止挡件的外侧与针筒的内表面之间限定密封界面;以及引发止挡件与针筒之间的相对运动,从而增强止挡件的外侧与针筒的内表面之间的密封界面。止挡件和管状构件之间的相对运动可包括旋转分量。可选地,止挡件和管状构件之间的相对运动包括纵向分量。止挡件的外侧可包括聚合物材料,并且增强止挡件的外侧与针筒的内表面之间的密封界面包括引发聚合物材料在密封界面处的聚合物运动。并且,作为另一种可选的步骤,在将止挡件从通气管递送到注入器装置的针筒中之后,止挡件的外侧包括在密封界面处起皱,并且进一步其中,增强止挡件的外侧和针筒的内表面之间的密封界面包括减少密封界面处的起皱。止挡件可以包括本体和联接至本体的屏障,屏障由含氟聚合物材料形成,并且增强止挡件的外侧和针筒的内表面之间的密封界面可以包括在密封界面处引起局部加热。并且,增强止挡件的外侧和针筒的内表面之间的密封界面可以包括将材料从止挡件的外侧转移至针筒的内侧。在各种示例中,止挡件的外侧限定肋部并且密封界面包括止挡件的肋部。
根据又一些其他示例,注入器装置包括止挡件,该止挡件具有外侧并且包括本体和由与本体的材料不同的材料形成的屏障,该屏障联接至本体,屏障限定止挡件的外侧的至少一部分;以及针筒,该针筒具有与止挡件的外侧接合的内表面以限定密封界面,针筒的内表面包括在密封界面处对应于屏障的材料的沉积的材料,使得密封界面由沉积的材料和屏障的材料限定,沉积的材料具有方向性定向。方向性定向可选地包括周向分量。沉积的材料的方向性定向可以由沿共同方向对准的PTFE链的多个行限定。止挡件的外侧可选地包括位于密封界面处的微肋部和宏观肋部中的至少一种,并且屏障可选地包括含氟聚合物材料。在一些示例中,沉积的材料填充针筒的内表面中的一个或多个缺陷。沉积的材料可选地仅位于密封界面处。密封界面可对应于一个或多个周向带,其中止挡件的外侧接合针筒的内表面。并且,沉积的材料可选地在针筒的内侧上限定一个或多个周向带。
前述示例仅仅是示例,而不应被理解为限制或以其他方式缩小由本公开以其他方式提供的任何发明构思的范围。尽管公开了多个示例,但是仍有其他实施例将从以下详细的描述中对本领域技术人员变得明了,以下详细的描述示出和描述了示意性示例。因此,附图和详细的描述应认为本质上为说明性的而非本质上为限制性的。
附图说明
包括附图以提供对本公开的进一步理解,并且附图包含在本说明书中且构成其一部分、示出实施例,并且与说明书一起用于阐释本公开的原理。
图1示出了根据一些实施例的构造为注射器的注入器装置。
图2示出了根据一些实施例的构造为自动注入器的注入器装置。
图3示出了根据一些实施例的图1或2所示的注入器装置的止挡件。
图4示出了根据一些实施例的图1或2所示的注入器装置的止挡件。
图5示出了根据一些实施例的图3或4所示的止挡件的一部分。
图6和7表示了根据一些实施例的图5的区域A中的各种微特征。
图8和9表示了根据一些实施例的工具和方法,工具可以通过这些方法用于止挡件组装和联接。
图10至14示出了根据一些实施例的组装图1或2所示的注入器装置的一些方法。
图15A和15B表示了根据一些实施例的用于修改止挡件的系统和方法。
图16A至19B表示根据一些实施例的对止挡件的修改,以移除缺陷。
具体实施方式
定义和术语
本公开不意在以限制性方式进行阅读。例如,应在本领域技术人员将归因于此类术语的含义的上下文中广义地阅读本申请中使用的术语。
提供标题的使用仅是为了便于审查描述,并不意味着隔离或以其他方式指定一个标题下的概念不适用或与另一标题下的概念无关。事实上,意图是相反的,并且说明书意在作为整体来阅读和解释,其中某些实施例的各种特征和方面可适用于本文描述的各种其他实施例。
关于不精确的术语,术语“约”和“大致”可互换使用,以指代包括所述测量值的测量值以及也包括与所述测量值合理地(相当地)接近的任何测量值。如相关领域的普通技术人员所理解和容易确定的,合理地(相当地)接近所述测量值的测量值偏离所述测量值的量合理地小。这样的偏离可归因于例如测量误差、测量值和/或制造设备校准的差异、读取和/或设定测量值的人为错误、考虑到与其他部件相关的测量值的差异为了优化性能和/或结构参数而进行的微调、特定的实施场景、由人或机器对物体进行的不精确的调节和/或操纵、和/或类似物。在确定了相关领域的普通技术人员不会容易地对于这种合理得小的差异确定值的情况下,则术语“约”和“大致”可理解为是所述值加减10%。
如本文所使用的,术语“可由能量源激活”及其类似术语是指材料状态的变化,诸如物理和/或化学状态的变化。由能量源激活的一个示例包括从固体形式(或更接近固体形式)到液体形式(或更接近液体形式)的显著(即,清晰明显)的变化。通过能量源激活的另一个例子包括通过暴露于能量源而表现出交联或分子量的显著(即,清晰明显)的变化(例如,经由交联或断链)。作为参考,如本文所使用的,“能量源”指的是多种类型的能量中的任一种的来源,多种类型的能量中包括热能、激光、射频(RF)、微波、紫外线、辐射、超声等。
如本文所使用的,术语“屏障”、“屏障构造”等是指阻挡或阻碍一个部件(例如,止挡件本体)与另一个部件(例如,针筒和/或针筒的内容物)之间相互作用的材料。
如本文所使用的,术语“弹性的”和“弹性体的”是指参考注入器装置中使用的止挡件(例如,在FDA批准的应用场合中)所理解的材料特性,并且涉及材料自发回复的趋势,或在尺寸方面变形(例如,收缩、扩张、扭曲等)之后朝向其变形前的形状恢复。
如本文所使用的,术语“注入器装置”意在包括以下多种装置中的任一种,这些装置包括接纳在针筒中的止挡件和致动机构,该致动机构构造成使针筒内的止挡件移位以从针筒内喷射或递送保持在针筒中的内容物。注入器装置的示例包括注射器、自动注入器和笔。
如本文所用,术语“宏观特征”(例如,如“宏观肋部”或“宏观凹槽”)意在表示其轮廓用肉眼可见的止挡件肋部或凹槽特征,或者表示高度为止挡件屏障厚度的两倍或更多倍的止挡件特征。
如本文所使用的,术语“微特征”(例如,诸如微肋部、微凹槽或微空隙)意在表示止挡件特征(无论是表面特征还是表面下特征),其轮廓是肉眼不可见的(尽管该特征的大致的存在本身可能是可察觉的)。例如,微特征将包括位于宏观肋部或宏观凹槽上或中的止挡件的微肋部或微凹槽特征。
如本文所使用的,术语“多层屏障”是指具有多个材料层的屏障构造,这些材料层的至少一些部分以一层在另一层之上的叠加(叠置)方式设置(并联设置),或者在一些情况下一个相邻另一个设置(串联设置)。多层构造可以具有带有相对尖锐、有区别的边界的材料厚度或材料层,或者可以在其间具有混合的或更平缓的过渡边界。
如本文所用,术语“多区域屏障”是指具有多个区域或具有不同材料特性的区段的屏障构造。多区域构造可以具有由相对尖锐、有区别的边界分隔开的区域或区段,或者可以具有混合的或平缓(逐渐)的边界。多区域屏障的一些示例包括并联或串联设置的不同层,使得多层屏障也限定多区域屏障。其他示例可以包括被修改以限定多个区域的单层。
如本文所使用的,术语“振荡”等(例如,“振荡(名词)”)意在表示以可以是恒定的或变化的频率沿方向交替的运动。
如本文所使用的,术语“近侧”意味着更靠近装置的操作者端(例如,柱塞端),而术语“远侧”意味着比近侧更远离操作者(例如,刺穿元件端)。
如本文所使用的,术语“旋转”等(例如,“旋转(名词)”)意在表示周向定向的运动。
如本文所使用的,术语“密封表面”意在表示维持液密密封(例如,在储存和/或使用中)的特征。
如本文所使用的,术语“硅酮”和“硅油”在本文中可以互换使用。
如本文所使用的,术语“基本上不含”意在表示无法计量的量的或痕量的已识别物质(例如硅酮、硅油或其他润滑剂),或者没有故意添加到系统中的任何量(例如,没有故意将硅油添加到注入器装置中,诸如针筒或止挡件)。
如本文所使用的,术语“振动”(例如,“振动(名词)”)意在表示具有以恒定的或变化的频率沿方向交替的加速度的交替运动。
各种实施例的描述
本领域技术人员将容易理解,本公开的各方面可通过构造成执行预期功能的任何数量的方法和设备来实现。还应注意的是,本文中参考的附图不一定是按比例绘制的,而有可能夸大以说明本公开的各个方面,并且就此而言,附图不应理解为限制性的。
本公开涉及注入器装置(例如,注射器、自动注入器和笔),其包括至少部分地覆盖有含氟聚合物或非含氟聚合物薄膜,或含氟聚合物或非含氟聚合物层合件的止挡件、包括针筒和柱塞杆或致动机构以使针筒内的止挡件移位。
本说明书的各个方面涉及当止挡件处于管状构件内时对止挡件的机械修改,管状构件诸如是注入器装置的针筒或可操作成用于将止挡件插入到注入器装置的针筒中的通气管。止挡件可以具有屏障,并且止挡件可以具有或可以不具有至少一个微特征(例如,由屏障形成)。这样的屏障可以包括多个层,或者可以是多层屏障。某些缺陷,诸如褶皱、划痕和碎屑,可能存在于处于其组装形式中的止挡件中,和/或可能在将止挡件组装到注入器装置的针筒中期间生成或以其他方式存在。可以在制造过程期间(例如,在将止挡件插入到针筒中之前或之后)实施对止挡件的机械修改(机械改型),以减少这种缺陷和瑕疵的影响。机械修改可以附加地或替代地将材料从止挡件转移至针筒以帮助减少针筒表面中的瑕疵的影响和/或生成包括相同材料的滑动界面。例如,由针筒上的转移材料和止挡件上的屏障材料形成的PTFE到PTFE(或ePTFE到eTPFE界面)可以具有增强的密封性能和/或滑动性能。可以设想,基于两种相似材料之间的表面能,这样的界面可能具有较低的泄漏可能性。
这些不同的特征又可以帮助在密封性能和/或滑动性能方面实现更好和/或更可重复的结果。利用这些特征可以实现各种附加或替代的优点,包括更高效和/或更高产量的制造、减少的污染和/或颗粒产生、增强的密封或其他。
注入器装置概念
在使用中,注入器装置可用于存储(例如,短期或长期)和递送流体,该流体通常是递送至患者用于医疗用途的治疗剂或其他物质。在一些实施例中,此类注入器装置可以在计划使用注入器装置以将治疗剂递送给患者之前预先填充有治疗剂(例如,作为预填充注射器)。注入器装置可包含治疗疾病的治疗剂,所述疾病诸如但不限于眼部疾病(例如,黄斑变性和青光眼)或糖尿病。随后描述潜在治疗(剂)的非限制性示例。有利地,在各种实施例中,止挡件和针筒不包含硅酮或硅油。例如,根据各种实施例,本文描述的注入器装置中的针筒和止挡件可以不含或基本上不含硅酮和硅油(或其他液体润滑剂)。在一些情况下,止挡件和针筒不包含任何大量的液体润滑剂,或者基本上不含任何其他液体润滑剂(当然,不包括注入器装置中呈液体形式的治疗物质,因此将自身润滑到至少一些程度)。
图1描绘了根据一些实施例的注射器形式的注入器装置10。如图所示,注入器装置10包括针筒20、刺穿元件30和止挡件40,止挡件40被接纳在针筒20中并且可操作地联接至致动机构50(例如,如图所示的柱塞杆)。
如图所示,针筒20具有壁118,并且在近端120和远端122之间延伸。针筒20具有内表面124和外表面126,内表面124和外表面126均由针筒20的壁118限定,内表面界定由针筒20限定的接纳腔室128。如图所示,针筒20的近端120还可包括凸缘,该凸缘可用作手指止挡件或手柄以协助用户按压和拉动致动机构50。
刺穿元件30可包括尖头针插管或钝端插管,诸如与“无针”系统一起使用的那些。为了便于说明,刺穿元件30被描绘为具有尖头远端的尖头细长针插管。如图所示,刺穿元件30与针筒20的远端122联接。
止挡件40构造成可滑动地接纳在针筒20中,并与针筒20的内表面124密封。更具体地,止挡件40构造成由致动机构50在针筒20内致动,以对接纳腔室128的内容物进行加压并通过刺穿元件30将接纳腔室128的内容物从针筒20排出。
致动机构50具有远端152和近端154,其中远端152可操作地联接至止挡件40,例如与止挡件40紧固、与止挡件40一体形成或以其他方式与止挡件40相关联,使得致动机构50构造成使止挡件40在针筒20内沿纵向(或其他)方向移位。
图2示出了根据一些实施例的自动注入器形式的注入器装置100,其中针筒20、止挡件40和致动机构50(也被描述为与注入器装置100相关的注入构件)可以类似地构造和使用。注入器装置100的致动机构50可采用或呈现施加到止挡件40的可变致动力。例如,致动机构50可包括一个或多个偏置构件(例如,弹簧)和用于实现这样的功能的其他特征。注入器装置100的各种其他部件基本上类似于注入器装置10的那些部件,如相关实践领域的技术人员将理解的。为了本描述的目的,本文描述的止挡件40的各种特征无论是用于注入器装置10的构造还是注入器装置100的构造中都是适用的。从更广泛的意义上来说,本文关于针筒20和止挡件40描述的概念能够以多种注入器装置构造中的任何一种来实现。
注入器装置10、100可包括位于针筒20的接纳腔室128中的材料60。在一些示例中,材料60在腔室中沉积在或以其他方式定位在制造部位处、或远离治疗部位的部位处、或注入器装置10、100将被最终用户使用的部位处(例如,在临床部位)。在这种情况下,注入器装置10、100可被称为“预填充的”(例如,在注入器装置10的示例中,预填充注射器)。材料60可以是预定量(例如,一个或多个剂量)的药物组合物。随后描述合适的药物组合物的一些示例。然而,应当理解,材料60可以是能够从注射器排出的任何类型的液体或材料,或者材料60可以一起不存在于接纳腔室中,诸如在未填充的注射器中。在这样的示例中,注入器装置10、100可以在治疗部位处或治疗部位附近被填充(例如,也被描述为对注入器装置“充注”)。
图3和4是止挡件40的示例性构造的平面图或正视图,其中止挡件40的右半部分以在图3的构造中的剖面图示出,而止挡件40的左半部分以在图4的构造中的剖面图示出。
如图3和4的每个构造所示,止挡件40包括由弹性材料制成的本体240和设置在本体240上的屏障242,诸如屏障薄膜。止挡件40具有外侧244、纵向轴线X、以及沿着纵向轴线X的高度。止挡件40在前面246和后面248之间延伸。如图所示,屏障242可沿着外侧244和/或前面246的一部分(包括整个外侧和/或前面)延伸。如果期望,屏障242还可以沿着后面248的一部分(包括整个后面)延伸。
在一些实施例中,本体240向止挡件40提供期望程度的弹性顺应性。例如,本体240可以在将止挡件40插入到针筒20中时被压缩,使得止挡件40与针筒20确实地(形状配合地)接合。下面进一步描述用于本体240的合适材料。
在各种示例中,设置在本体240上的屏障242构造成抑制物质通过屏障242从本体240迁移(或迁移到本体240),减少止挡件40和针筒20之间的滑动和/或静摩擦,和/或者增强止挡件40和针筒20之间的密封。这些特征是在示例性意义上提及的,并且并不意味着排他性地列出。屏障242可以是单层或多个层。屏障242可由相对于彼此具有独特(不同)的性质的多个层构造而成,和/或屏障可包括具有相似性质的多个层,这些层被熔合或以其他方式联接以形成层与层之间具有更均质特性的更均质的构造。屏障242还可以包括用作屏障242的一层或多层的复合材料(例如,基质薄膜材料和填料)。下面进一步描述用于屏障242的合适的材料。
如图3和4的每个构造所示,止挡件40具有短的圆柱形形状,其中前面246由止挡件40的锥形端限定。如图所示,锥形端可以远离纵向轴线X突出以限定钝角。在致动机构50使用螺纹紧固设置来联接至止挡件40的示例中,止挡件40可包括在后面248中的具有内螺纹的轴向凹部250。
如图所示,止挡件40的外侧244可限定一个或多个肋部300,也被描述为宏观肋部,诸如一个或多个周向延伸的环形肋部300,和/或一个或多个凹槽310,也被描述为宏观凹槽310,诸如一个或多个周向延伸的环形凹槽310。在操作中,一个或多个肋部300构造成以滑动接触方式接合针筒20的内表面124(图1和2)。止挡件40可构造成实现具有高水平的气体(例如,空气)和液体不可渗透性的容器封闭件完整性,同时还维持可接受的低断裂(松开)力、低平均滑动力和低滑动力变化中的一种或多种。
肋部300可以构建成任何数量的构造。例如,仅最远部的肋部或前肋部可以具有密封表面。应当理解,由此形成的密封的质量可以通过本领域技术人员熟悉的任意数量的方法(例如氦泄漏测试)来评估。在一些实施例中,多个肋部300可具有密封表面。在一个或多个实施例中,具有密封表面的所有肋部300可具有相同的预先限定的外径(例如,在止挡件40处于非压缩状态时从相应肋部的顶点测量)。在其它实施例中,具有密封表面的每个肋部300可具有其自己的预先限定的外径。例如,远侧肋部或前肋部可具有预先限定的外径,并且近侧肋部或后肋部可具有预先限定的外径,近侧肋部或后肋部的该预先限定的外径在远侧肋部或前肋部的预先限定的外径的约75%至约99.9%之间。在不脱离本公开的精神和范围的情况下,可以设想其他类型的肋部设置,诸如例如具有带有密封表面的三个肋部。
尽管图3和4中示出了三个肋部300,但是应当设想任何数量的肋部(例如,一个、两个、四个、十个等等)。如图所示,肋部300包括前肋部300A,该前肋部具有构造成与针筒20的内表面124滑动接触的密封表面320A(也描述为滑动接触部分320A)。如图3所示,肋部300中的一个或多个可选地具有平坦轮廓(例如,前肋部300A),其中密封表面(例如,密封表面320A)可以稍微平坦,并且其宽度是止挡件40的外侧244的长度的1%至25%。如图4所示,一个或多个肋部300(例如前肋部300A)可选地具有向外凸出的形状,其中密封表面(例如密封表面320A)具有相对较窄的轮廓。如图3和4所示,肋部300还包括中间肋部300B和后肋部300C。如图所示,中间肋部300B和后肋部300C可选地具有以剖面图看到的向外凸出的形状。中间肋部300B和后肋部300C中的每一个可选地分别具有密封表面320B、320C,密封表面320B、320C构造成与针筒20的内表面124滑动接触。在一个或多个肋部300具有向外凸出的形状的情况下,当沿着止挡件40的纵向轴线X测量时,相应的密封表面可具有相对较小的宽度。根据构造,每个密封表面320B、320C(也被描述为滑动接触部分320B、320C)可具有止挡件40的外侧244的长度的大于0%且(最)高达15%的宽度。
如图3和4所示,止挡件40的外侧244可包括一个或多个缺陷900,诸如褶皱362和划痕364(可以在图16A中找到,并结合图16A描述呈碎片形式的缺陷900的示例)。各种缺陷900,诸如褶皱362和/或划痕364可纵向地定向、周向地定向,或两者皆可(例如,螺旋地)。缺陷900可以是相对线性的、弯曲的或两者。缺陷可位于止挡件40上的任何位置处,但是可能特别普遍存在于肋部300和相关联的密封表面320上,以及在一个或多个微特征400上或沿着一个或多个微特征400,诸如随后描述的那些。这些缺陷可能在制造过程中在任何点处形成,包括当止挡件40首次形成时(例如,当屏障242附连至本体240时)或在将止挡件40安装到针筒20中的过程期间。例如,当止挡件沿直径方向被压缩时,可能形成褶皱362。并且,例如当止挡件40抵靠针筒20或在组装过程中使用的另一管状构件滑动时,可能形成划痕364。
如图3和4所示,止挡件40的外侧244可包括一个或多个缺陷900,诸如褶皱362和划痕364(可以在图16A中找到,并结合图16A描述呈碎片形式的缺陷900的示例)。各种缺陷900,诸如褶皱362和/或划痕364可纵向地定向、周向地定向,或两者皆可(例如,螺旋地)。缺陷900可以是相对线性的、弯曲的或两者。缺陷可位于止挡件40上的任何位置处,但是可能特别普遍存在于肋部300和相关联的密封表面320上,以及在一个或多个微特征400上或沿着一个或多个微特征400,诸如随后描述的那些。这些缺陷可能在制造过程中在任何点处形成,包括当止挡件40首次形成时(例如,当屏障242附连至本体240时)或在将止挡件40安装到针筒20中的过程期间。例如,当止挡件沿直径方向被压缩时,可能形成褶皱362。并且,例如当止挡件40抵靠针筒20或在组装过程中使用的另一管状构件滑动时,可能形成划痕364。
微特征概念
如图3和4所示,止挡件40包括位于一个或多个肋部300处(例如位于前肋部300A的滑动接触部分320A处)的一个或多个微特征400。在一些示例中,一个或多个微特征400包括一个或多个微凹槽和/或微肋部。在一些示例中,微特征400具有宽度和深度,其中深度在微肋部的情况下是突出的量,在微凹槽的情况下是凹陷的量。在一些实施例中,宽度和深度中的一者或两者不大于200μm、不大于100μm、不大于50μm、不大于10μm、或例如不大于5μm,但可以设想有多种尺寸。注意,前述每个“不大于”范围包括大于“零”的值。
图5表示止挡件40的沿着止挡件40的外侧244(例如,在肋部300中的一个处,诸如第一肋部300A)的一个或多个部分的放大剖视图。尽管图5示出了第一肋部300A,但是与第一肋部300A相关地描述的相同概念可以适用于任何肋部300。图6和7表示了可选地包括在图5上标注的区域“A”中的各种微特征。微特征可以由屏障242和/或本体240形成。
考虑到前述内容,图5示出了根据一些实施例的止挡件40的本体240和屏障242以及针筒20的剖视图(例如,在其中止挡件40的外侧244与针筒20的内表面124接合的位置处)。如图所示,屏障242可选地包括多个层,或者是包括第一材料的第一层402和第二材料的第二层404的多层屏障。屏障242可以具有多种厚度中的任一种,诸如在1μm至200μm之间。
如图所示,如果存在,则第一层402可以定位在第二层404下方。尽管总体示出了两个层,但是应当理解,可以设想任何数量的层,包括单个层。如图所示,第一层402具有面向止挡件40的本体240的内表面410和面向第二层404的外表面412。第二层404又包括面向第一层402的内表面420和背离本体240的外表面422。在各种示例中,第一层402的内表面410联接(例如,结合、粘附、紧固或以其他方式联接)至本体240。并且,进一步地,第二层404的内表面420联接(例如,结合、粘附、紧固或以其他方式联接)至第一层402。在一些实施例中,第一层402可被称为屏障242的“内层”并且第二层404可以被称为屏障242的“外层”,尽管第一层402和/或第二层404中的任一个可以是定位在屏障242的一个或多个其他层之间的中间层或埋入层。
在各种示例中,多个层中的一个(例如,第一层402)可以包括比多个层中的另一个(例如,第二层404)的第二材料更容易由能量源激活的第一材料。具体地,可以利用一层比另一层更容易由能量源激活的这一特征来优先在屏障242中在各种位置处形成多种微特征400。
屏障242可以考虑多种材料,包括单独描述的那些。例如,屏障242(例如,第一材料和/或第二材料)可包括含氟聚合物(例如,聚四氟乙烯(PTFE)或膨胀型PTFE(ePTFE))。在一些示例中,第一层402是微孔的并且限定第一孔隙率,并且第二层404具有比第一层更低的孔隙率,并且可选地,第二层404的特征在于比第一层402更高的熔融温度。如果期望,第二层404的特征可以在于比第一层402具有更高的尺寸稳定性。第一层402的第一材料和第二层404的第二材料中的至少一个可以包括热塑性材料。如果期望,第一层402的第一材料可以包括构造成增加第一材料的光能和/或射频能量的吸收的填料。并且,填料可以包括例如氟化乙烯丙烯(FEP)和乙烯四氟乙烯(ETFE)中的至少一种。
图6和7示出了微特征的示例。图6示出了呈微肋部400A的形式的潜在微特征400的示例,并且图7示出了呈微凹槽400B或微空隙400B的形式的潜在微特征。尽管图6和7各自示出了微特征示例,但是应当理解,可以存在任意数量的微特征或者可以设想用于止挡件40的微特征的任意组合。形成此类微特征的示例方法将包括将能量源引导至屏障242处以形成此类特征、预模制或模制此类特征、或多种其他形成方法中的任何一种。
在特定微特征400处或附近形成各种微特征(例如,微空隙、微凹槽或微肋部)之后,大致来说是屏障242,并且更具体地是第一层402和/或第二层404可以表现出相对于屏障242的周围部分相对不同的物理特性,诸如以下的一种或多种:在微空隙或微凹槽的情况下增加的顺应性;在微空隙或微凹槽的情况下降低的抗压性;在微肋部的情况下增加的抗压性,在微空隙或微凹槽的情况下减少的厚度;在微肋部的情况下增加的厚度;或在微空隙或微凹槽的情况下降低的拉伸强度。这样的特性可以有利于减少肋部300的有效密封表面积(例如,以优化宏观肋部的增加的密封力和减少的滑动阻力之间的关系)、为屏障242创建优先失效线(例如,以为屏障撕裂或无法避免注入器装置10的内容物污染和/或密封失效而预先选择更期望的区域)以填充针筒20和止挡件40之间的一个或多个空隙或缺陷,或者性能和可靠性方面的其他优点。
尽管先前已参考,但为了避免疑问,各种多层屏障构造可以包括多于两层(例如,总共五层)。第一层402和/或第二层404可以如结合先前示例所描述的,可以位于层内的任何位置处。并且,在各种实施方式中可以存在更多或更少的层。例如,第一层402可以是最内层或埋入层。例如,第二层404可以是最外层或埋入层。并且,第一层402和第二层404可以接触,或者被一个或多个其他层分开。并且,根据各种实施例,可以存在单个层。
上述各种微特征400可具有多种尺寸中的任一种。在一些示例中,微凹槽中的一个或多个具有从0.25μm至50μm,并且可选地从0.25μm至0.5μm的深度以及从0.25μm至50μm,并且可选地从0.25μm至0.5μm的宽度,和/或微肋部中的一个或多个具有从0.25μm至50μm,并且可选地从0.25μm至0.5μm的高度,以及从0.25μm至50μm,并且可选地从0.25μm至0.5μm的宽度。如随后将描述的,微凹槽和/或微肋部可以具有多种构造中的任一种,例如沿周向方向、螺旋方向、或甚至纵向方向延伸。
止挡件组件和联接机构
可以设想组装止挡件,特别是将屏障242和本体240设置在一起的各种方式。
例如,图8包括了工具3000的使用,该工具包括模具3002和诸如心轴3004之类的成形设备。模具3002包括由内部壁3008限定的空腔3006。空腔3006的形状和尺寸设计成产生具有期望形状和尺寸的止挡件40。如图所示,工具3000构造成由屏障材料的预成形件2000a和本体材料的预成形件2000b制造止挡件40,预成形件2000a、2000b中的每一个以片材或相对平坦的形式开始。
预成形件2000a、2000b可选地对准,然后受迫(例如,同时)进入模具3002的空腔3006中,如图所示。由此,本体240由预成形件2000b形成,其中屏障242由预成形件2000a共同模制或层合在其上,以形成如图所示的止挡件40。在所示实施例中,心轴304被致动以迫使预成形件2000a、2000b进入模具3002中。在一些实施例中,心轴3004可以构造成在成形期间在本体240中限定结构(例如,后面248中的带内螺纹的轴向凹部250)。
注射模制、压缩模制、真空压制模制、共同模制或其他已知或以其他方式常规的工艺和设备也可以用于使用预成形件2000a、2000b来制造止挡件40。
作为另一示例,图9示出了一些实施例,示出了如何将呈圆柱形形式的屏障242的材料的预成形件2000c与片材形式的本体240的材料的预成形件2000b组合以组装止挡件40。如图9所示,该过程包括使用工具3000,该工具3000包括模具3002和诸如心轴3004之类的成形设备。模具3002包括由内部壁3008限定的空腔3006。空腔3006的形状和尺寸设计确定成产生止挡件40。
工具3000构造成由屏障材料的预成形件2000c和限定预成形件2000b的质量体材料制造止挡件40。如图所示,屏障材料的预成形件2000c定位在模具3002的空腔3006中。然后将本体材料的预成形件2000b施加到屏障材料的预成形件2000c内的内部空隙区域。如图所示,心轴3004被致动以迫使可以是固体或半固体形式的预成形件2000b通过预成形件2000c的开口近端部分进入预成形件2000c。心轴3004可以构造成限定预成形件2000b中的结构(例如,后面248中的具有内螺纹的轴向凹部250)。
尽管可选地使用心轴3004,但在其他实施例中,通过其他方法将本体材料沉积到屏障材料的预成形件2000c中,诸如通过施加压力以可流动流体或其他流体的形式。注射模制、压缩模制、真空压制模制、共同模制或其他已知或其他方式常规的工艺和设备可以用于使用预成形件2000c来制造止挡件40。
可以应用对前述内容的各种修改来增强或实现部件结合。在一些示例中,屏障242可以在一个或多个微特征400的形成期间或通过用能量源激活第一层402而结合(或进一步结合)至本体240。还设想了附加地使用粘合剂、弹性体结合材料、表面处理和其他实践。
止挡件插入概念
图10-14是一系列步骤的示意图,通过这些步骤,插入设备4260可以用于将止挡件40插入到针筒20中,针筒20可预填充或随后填充有多种内容物中的任何一种,诸如本文描述的治疗物质中的任何一种。如图所示,插入设备4260包括插入销4262和通气管4264。通气管4264包括细长管状构件4266,该细长管状构件4266的外径小于针筒20的内径,并且内表面4267的内径足够大以容纳止挡件40。也许如图11最佳地所示,通气管4264的管状构件4266通过其近端插入到针筒20中。在一些实施例中,通气管4264的远端部分4268位于与组装的注入器装置10、100中的针筒20中的止挡件40的期望位置相对应的位置处。例如,如图11和12所示,当管状构件4266定位在针筒20中时,通气管4264的远端部分4268定位成邻近诸如治疗物质之类的注射器内容物的表面。
插入销4262具有小于通气管4264的内径的外径以及远端部分4263。在实施例中,通气管4264的内径小于止挡件40的外径。通气管4264的近端部分4270具有渐缩内部引导表面4272。也许如图11和12最佳地所示的,当通气管4264定位在针筒20中时,插入销4262被致动或运动以使其远端部分4263与止挡件40接合,并迫使止挡件40或以其他方式驱动或移动止挡件40进入通气管4264的近端部分4270,并穿过管状构件4266到达通气管4264的远端部分4268。通过插入销4262的这个动作,止挡件40沿直径方向压缩(例如,当止挡件40运动穿过渐缩引导表面4272时),并且定位在沿着针筒20的长度的位置处,该位置是止挡件的在组装的注入器装置10、100的针筒中的期望位置(例如,邻近针筒20中的治疗物质)。
也许如图13最佳地所示的,当插入销4262和针筒20的相对位置保持固定时,通气管4264从针筒20的近端撤回。在通气管4264的移除期间,插入销4262将止挡件40保持在针筒20中的期望的位置处,从而导致止挡件40被推出通气管4264的远端部分4268。在离开通气管4264之后,止挡件40沿直径方向膨胀以与针筒20接合(例如,止挡件40的外侧244在一个或多个密封界面处接合针筒20的内表面124)。由此,止挡件40在针筒20中定位在其期望位置处。然后,插入销4262和通气管4264可以从针筒20中撤回,如例如图14所示。
上面结合图10-14所描述的止挡件插入过程可能产生褶皱或表面缺陷,如随后描述的。具体地,在凹槽310和/或肋部300附近可能产生不规则成形地且细长的凸起。这些不规则形状和细长的结构在本文中可被称为褶皱或表面缺陷900(图3、16A、18A和19A),它们在将止挡件40插入到针筒20中之后,在密封界面702(图15B)处可具有沿相对于纵向轴线X大致平行、垂直或者成任意角度的方向的实质性(较大)的分量。褶皱或表面缺陷900(图3)可能对密封界面的密封特性产生损害或负面影响。例如,它们可以用作允许不期望的气体和/或液体经过止挡件40进入或排出。
如前所述,在针筒20内对止挡件40进行修改可有助于减少这种褶皱或表面缺陷900(图3)和/或总体上增强止挡件40和针筒20之间的密封。
修改系统和方法概念
图15A是根据实施例的可用于制造包括止挡件14的注入器装置10的修改系统5230的示意图。修改系统5230可以用于执行止挡件40和/或针筒20的处理(例如,在止挡件40插入到针筒20之前、在止挡件40插入到针筒20中时、和/或在止挡件40已插入到针筒20中之后)。各种示例涉及用于制造注入器装置10、100的方法,包括将注入器装置10、100的止挡件40定位在管状构件5300(例如,针筒20或通气管4264)中,使得止挡件40的外侧244与内表面5310(例如,针筒20的内表面124或通气管4264的内表面4267)接合。止挡件40能够以多种方式中的任何一种方式与针筒20的内表面124接合,包括通过使用通气管4264。并且,止挡件40能够以多种方式中的任一种与通气管4264的内表面4267接合,包括结合图10至14描述的那些方式。
在各种示例中,修改止挡件40的外侧244包括引起止挡件40和管状构件5300的内表面5310之间的相对运动,该相对运动包括旋转运动和线性运动中的一者或两者。这种旋转运动可以是转过任意角度的旋转,诸如5度或更多度、10度或更多度、20度或更多度、40度或更多度、100度或更多度、180度或更多度、360度或更多度、大于360度、720度或更大、或上述值之间的任何其他值或范围。相对运动本质上可以是振荡的(例如,振动的),或者是连续的或不连续的。振荡相对运动能够以任何期望的频率发生,例如0.5Hz或更高、1Hz或更高、5Hz或更高、10Hz或更高、20Hz或更高、50Hz或更高、100Hz或更高、或上述值之间的任何其他值或范围。修改系统5230可以构造成施加这样的相对运动。相对运动可在止挡件和管状构件(例如,注射器针筒20或通气管)之间的(一个或多个)界面处引起局部加热,或者更一般地说生成能量。
在各种实施例中,提供针筒20和止挡件40之间的相对运动的修改系统5230增强了注入器装置10的特性,诸如止挡件40的密封能力。这些增强的特性可以例如通过抛光或以其他方式使最终接触针筒20的内表面124的止挡件40的外侧244变平滑来产生,和/或通过将止挡件的外侧244的材料转移并沉积到针筒20的内表面124上(例如,当止挡件40在其中被修改的管状构件5300是针筒20时)来产生。在各种实施例中,由修改系统5230提供的处理可以在注入器装置10被填充(例如,用诸如先前描述的内容物)之后执行。
如上所述,修改系统5230可以用于止挡件20的针筒内处理,和/或修改系统5230可以用于在将止挡件40插入到针筒20中期间当止挡件40位于通气管4264内时执行对止挡件40的处理,诸如结合图10至14所描述的。通过这些实施例,止挡件40的表面粗糙度的减小是通过止挡件40相对于通气管4264的相对运动来提供的。
如图所示,修改系统5230包括驱动模块5234和控制模块5236,驱动模块5234和控制模块5236可以操作成处理(加工)止挡件40的外侧40和/或管状构件5300的内表面5310。在所示实施例中,包括联接至止挡件40的轴5237(其可以是致动机构50(图1和2))的驱动模块5234由控制模块5236控制并在管状构件5300和止挡件40之间产生相对运动。例如,模块5234可以引起止挡件40相对于管状构件5300沿大致垂直于止挡件40的纵向轴线X的方向的旋转5240(例如,通过使轴5237旋转)(图3和4)。替代地或附加地,驱动模块5234可以引起止挡件40相对于管状构件5300沿平行于止挡件40的纵向轴线X的方向的线性运动5242(例如,通过使轴5237相对于管状构件5300运动)。旋转5240和/或线性运动5242可以沿第一方向或第二相反方向,或往复运动。在各种实施例中,旋转5240和/或线性运动5242是沿第一方向和第二相反方向的往复运动,并且可以是周期性的。
替代地或附加地,驱动模块5234可以通过使管状构件5300沿大致垂直于止挡件40的纵向轴线X的方向旋转而引起管状构件5300相对于止挡件40的旋转5244。替代地或附加地,驱动模块234可以通过使管状构件5300沿平行于止挡件40的纵向轴线X的方向运动而引起管状构件5300相对于止挡件40的线性运动5246。例如,修改系统5230可包括致动组件5238(例如,滚轮、平台或其他可致动构件),该致动组件固定至管状构件5300并构造成使管状构件5300运动。管状构件5300的旋转5244和/或线性运动5246可以沿第一方向或第二相反方向,或往复运动/振荡运动。在各种实施例中,针筒20的旋转5244和/或线性运动5246是沿第一方向和第二相反方向的往复运动,并且可以是周期性的。管状构件5300和止挡件40之间的旋转5240、5244和/或线性运动5242、5246可以是振动运动。
在一些实施例中,修改系统5230能够以多种组合、速率、方向和/或频率中的任一种产生管状构件5300相对于止挡件40的相对旋转5240和/或5244和/或相对线性运动5242和/或5246。在一些实施例中,由修改系统5230产生的相对运动具有比线性运动5242和/或5246更大的旋转5240和/或5244的量。在该相对运动期间,管状构件5300的内表面5310相对于止挡件40的外侧244运动的距离沿旋转5240和/或5244的周向方向可能比沿平行于线性运动5242和/或5246的方向更大。在一些实施例中,旋转5240和/或5244显著大于在止挡件加工/修改期间由修改系统5230产生的线性运动5242和/或5246。在一些实施例中,当止挡件40沿着平行于纵向轴线X的路径被驱动到管状构件5300中(例如,没有往复运动)时,止挡件40可以相对于管状构件5300旋转。例如,在纵向插入到通气管4264和/或针筒20中期间止挡件40可以旋转,以修改止挡件40的表面和/或通气管4264和/或针筒20的内表面。
管状构件5300(可选地,通气管4264和/或针筒20)中的这种表面修改或加工(处理)可以帮助减小最终接合针筒20的止挡件40的外侧244的粗糙度。粗糙度可以沿周向方向和/或纵向方向减小。在一些示例中,表面粗糙度垂直于相对运动的方向减小(例如,在旋转5240和/或5244的情况下,纵向表面粗糙度可减小,并且在线性运动5242和/或5246的情况下,周向表面粗糙度可减小)。
在一些实施例中,用修改系统5230对止挡件40的处理在环境温度下进行(例如,无需通过外部源加热或冷却),但是可以设想在用修改系统5230处理止挡件40期间改变了温度(例如,升高的温度)。由修改系统5230赋予的管状构件5300和止挡件40之间的相对运动可引起管状构件5300和/或止挡件40的加热,并且这种加热可如上所述地减小止挡件40的外侧244的粗糙度。
控制模块5236构造成控制系统1000的操作。在各种示例中,控制模块5236可以包括电源(未示出)、一个或多个微处理器、一个或多个用户输入装置(例如,键盘)、一个或多个显示装置(例如,监视器)、以及用于控制系统5230的操作的其他特征。
电源可以向控制模块5236的操作部件和/或系统5230的其他部件提供电力,并且可以是适合于提供控制模块5236和/或系统5230的期望性能和/或寿命要求的任何类型的电源。在各种实施例中,电源可以包括一个或多个电池,其可以是可再充电的(例如,使用外部能量源)。
控制模块5236可以包括或者被包括在一个或多个现场可编程门阵列(FPGA)、一个或多个可编程逻辑器件(PLD)、一个或多个复杂PLD(CPLD)、一个或多个定制专用集成电路(ASIC)、一个或多个专用处理器(例如微处理器)、一个或多个中央处理单元(CPU)、软件、硬件、固件或这些和/或其他部件的任意组合。控制模块5236可以包括构造成与存储器通信以执行存储在存储器中的计算机可执行指令的处理单元。附加地或替代地,控制模块5236可以构造成将信息(例如,感测数据)存储在存储器中和/或从存储器访问信息(例如,感测数据)。
在一些实施例中,存储器包括易失性和/或非易失性存储器形式的计算机可读介质并且可以是可移除的、不可移除的或其组合。介质示例包括随机存取存储器(RAM);只读存储器(ROM);电可擦除可编程只读存储器(EEPROM);闪存;光学或全息介质;磁带盒、磁带、磁盘存储器或其他磁存储装置;数据传输;和/或可用于存储信息并可由计算设备访问的任何其他介质,计算设备诸如例如量子态存储器等。在各实施例中,存储器存储计算机可执行指令,用于使处理器实现本文讨论的系统组件的实施例的各方面和/或执行本文讨论的方法和过程的实施例的各方面。
计算机可执行指令可以包括例如计算机代码、数字信号处理、机器可用指令等,诸如能够由与计算设备相关联的一个或多个处理器执行的程序成分。程序成分可以使用任意数量的不同编程环境来编程,包括各种语言、开发套件、框架和/或类似物。本文设想的一些或全部功能还可以或替代地以硬件和/或固件来实现。
在一些实施例中,驱动模块5234由控制模块5236控制并且在表面修改期间在止挡件部件(例如本体240和/或屏障242)与管状构件5300之间产生相对运动。如所提及的,驱动模块5234可以引起一个或多个止挡件部件(例如,本体240和/或屏障242)和/或管状构件5300的旋转。并且,驱动模块5234可以附加地或替代地产生止挡件部件(例如,本体240和/或屏障242)和/或管状构件5300的轴向运动。驱动模块5234可以包括驱动马达、传感器、控制电路、驱动轴、转台和/或用于实现期望的相对运动的各种附加或替代部件。
可以设想的是,在用修改系统5230处理(加工)期间产生的热量可以导致止挡件40的材料的温度(例如,在外侧244处)增加到足以促进在外侧244处的聚合物运动并减少褶皱、划痕、碎片或其他不想要的表面缺陷,这些缺陷可能导致表面粗糙度和/或在止挡件40和针筒20之间的界面处出现密封缺陷的可能性。由相对运动引起的温度升高可能低于熔融温度、高于熔融温度、或以其他方式处于期望温度,当与相对运动引起的机械接合/操纵相耦合时,表面缺陷/粗糙度根据期望减少。在各种示例中,止挡件40和管状构件5300之间的相对运动导致对肋部300中的一个或多个进行局部加热。
尽管一般性地示出了止挡件40,但是这些修改可以仅应用于肋部300或微肋部400,而不是应用于整个外侧244。事实上,表面修改可以仅应用于一个肋部300或者甚至一个微肋部400。修改的量或程度可能受到止挡件40的初始几何形状的影响。例如,与针筒20具有较大过盈配合的那些肋部300将自然地引起较高程度的摩擦和能量。在一些示例中,第二或第三肋部300可构造成以促进表面修改的方式与针筒20接合。通过促进在一个或多个中间肋部处的修改,而不是在前肋部处进行修改,可以帮助避免不期望的颗粒产生和沉积到针筒内容物中的问题。
还可以设想,对管状构件5300中的止挡件40的加工可处理外侧244的粗糙度的减小,而不产生大量的不想要的颗粒/污染物。作为表面修改的一部分或以其他方式形成的颗粒可以聚结或封装到止挡件40的变形材料或熔融的材料中。
还可以设想,在使用修改系统5230进行针筒内处理期间,可以减少针筒20中的表面缺陷以增强密封和/或滑动性能。例如,针筒20和止挡件40之间的相对运动可引发材料从止挡件40的外侧244涂抹或转移到针筒20的内表面124上。材料的这种转移可产生密封线(例如,以摩擦焊缝的形式)或者可以简单地填充针筒20中的表面不规则处(例如,划痕)以促进与止挡件40的更可靠的密封。材料从止挡件40到针筒20的这种转移帮助减少了针筒表面(内表面124)中的瑕疵的影响和/或生成密封界面702的构造,在该构造中密封界面702包括相同或相似的材料。例如,由针筒20上的转移材料和止挡件40上的屏障材料242形成的PTFE到PTFE(或ePTFE到eTPFE界面)可以具有增强的密封和/或滑动性能。可以设想,基于两种相似材料之间的表面能,密封界面702的这种构造可以具有较低的泄漏可能性。
本公开的各个方面涉及用于制造注入器装置10、100的方法,包括经由相对移动或运动来修改止挡件40。在各种示例中,修改止挡件40包括修改止挡件40的外侧244,例如通过熔融止挡件40的一部分以其他方式引起止挡件40的一部分的聚合物运动,这可以最终改善止挡件40与针筒20的密封完整性。可以设想,密封完整性可以通过例如减少止挡件40的外侧的表面粗糙度、减少止挡件40的外侧244中的起皱、在止挡件40的外侧244与针筒20的内表面124之间形成密封线、和/或减少止挡件40和针筒20之间的一个或多个泄漏路径中的一种或多种来改善。在一些示例中,修改止挡件包括通过将能量穿过针筒20的壁118引导至可激活层来修改止挡件40的可激活层。
图16A至19B是示出了这种制造技术在与图5所示的止挡件40的区域“A”相对应的密封界面702处的潜在益处的示意图。图16A至18B指示了针筒20中的呈表面不规则部的形式的潜在缺陷700,因为针筒20的内表面124不是完美平滑的。这样的缺陷700可以是划痕、不规则部、空隙或孔、或其他特征。如图16A所示,可以设想,在各种实施例中,在通过引发针筒20和止挡件40之间的相对运动来对止挡件40进行表面修改之后,止挡件40的屏障242可以通过容纳(适应)或更好地填充缺陷700(例如,在止挡件40接合针筒20的位置处,诸如接近宏观特征和/或微特征400)来更紧密地适形于针筒20。图16B旨在说明这个概念,其中示出了缺陷700至少部分地填充有来自止挡件40的外侧244的材料,并且具体地是止挡件40的屏障242的材料。
如前所述,止挡件40的外侧244可包括聚合物材料(例如,FEP、ePTFE、PTFE和/或本文描述的另一种聚合物材料),聚合物材料与针筒20形成密封界面702,并且修改止挡件40包括经由各部件的相对运动而在密封界面702处引发聚合物材料的聚合物运动。如图16A所示,在这样填充或容纳(适应)缺陷700之前,在止挡件40(屏障242)和屏障20之间可能存在空间710或潜在泄漏路径710。并且,在修改表面之后,空间710或潜在泄漏路径710在密封界面702处被更有效地密封或封闭。这又可以导致在密封界面702处(例如,接近宏观特征300或微特征400中的一个或多个)的相对更安全或稳定的密封。
而且,如图16A所示,止挡件40的外侧244和针筒20之间的密封界面702可包括引入到密封界面702中的颗粒800(例如,碎片)。这种颗粒可包括止挡件40或针筒20在制造期间中折断、松动的部分,或其他异物。如图16B所示,在针筒内处理期间,这种颗粒可以回流或聚结到密封界面702中。显然,这种颗粒的减少将是期望的,特别是在针筒的内容物特别不期望被污染的制药应用场合中。
而且,如图16A所示并且如之前关于图3和4所参考的,止挡件40的表面,具体地是屏障242,可以包括一个或多个褶皱或表面缺陷900。这样的表面缺陷900可以在将止挡件40插入针筒20期间、在制造期间、或在其他情况下产生。通过在止挡件和管状构件5300(例如,如图16A和16B所示的针筒20)之间引发的相对运动来修改注射器止挡件40可以导致屏障242的材料的聚合物运动,从而使表面缺陷或褶皱变平滑。这又可以帮助使止挡件40的外侧244与针筒20的内表面124更加适形(在止挡件40被组装到针筒20中之后,或者在止挡件40被组装到针筒20中之后)。这又可以说是减小了止挡件40的外表面244的粗糙度。如前所述,能够以周向图案(例如,通过连续的、振荡的或其他相对旋转)将表面修改应用于止挡件以帮助增强密封完整性。
图17A和17B示出了类似的效果,其中屏障242的表面被回流或使用能量(例如,摩擦能)移动,以填充针筒20的内表面124中的缺陷(例如划痕或凹槽)。如图17A所示,在针筒20和止挡件40之间存在空间或潜在的泄漏路径710。通过引起相对运动以及屏障242的表面的移动,潜在的泄漏路径710被填充,从而增强总体密封完整性。并且,类似于图16A和16B,能够以期望的图案(例如,周向和/或纵向的)施加相对运动以产生期望的效果。
图18A和18B示出了与图16A至17B类似的关于向止挡件40施加能量以引起止挡件40的表面修改的原理。图18A和18B是沿着剖过注入器装置10的横向截面的图示。图18A和18B可以表示包括图5中指定的区域“A”的注入器装置10的横向截面,例如在止挡件40和针筒20之间的密封界面702处。图18A从纵向视图描绘了针筒20,并且具体地描绘了围绕针筒20的内表面124的周缘的呈表面不规则部(例如,划痕)的形式的缺陷700。还示出了围绕止挡件40的周缘的外侧244中的褶皱或表面缺陷900。
图18B示出了在表面修改之后在密封界面702上的设想的效果。如图所示,所引发的止挡件40(例如,屏障242)的聚合物运动可导致对针筒20中的缺陷700的填充、止挡件40中的褶皱或表面缺陷的平滑、密封界面702的增强、以及对应于例如密封界面702的周向密封线的产生。
鉴于前述,用于制造注入器装置10、100的各种方法包括止挡件40的针筒内处理。示例方法可包括将止挡件40定位在通气管4264中;将通气管4264插入到针筒20中;将止挡件40从通气管4264递送到针筒20中,使得外侧244与针筒20的内表面124接合,以在止挡件40的外侧244和针筒20的内表面124之间限定密封界面702;以及引起止挡件40和针筒20之间的相对运动,以增强止挡件40的外侧244和针筒20的内表面124之间的密封界面702。如前所述,相对运动可以包括旋转分量、纵向分量或其组合。如所讨论的,在将止挡件40从通气管4264递送到针筒20中之后,止挡件40的外侧244可包括在密封界面702处起皱,并且增强止挡件40的外侧244和针筒20的内表面124之间的密封界面包括减少密封界面702处的起皱。止挡件40的外侧和针筒20的内表面124之间的密封界面702的增强包括将材料从止挡件40的外侧244转移至针筒20的内侧124。肋部300中的一个或多个可限定密封界面702。
如前所述,可以进行材料从止挡件40到针筒20的这种转移,以帮助减少针筒表面(内表面124)中的瑕疵的影响和/或生成密封界面702的构造,在该构造中,密封界面702包括相同或相似的材料。例如,由针筒20上的转移材料和止挡件40上的屏障材料242形成的PTFE到PTFE(或ePTFE到eTPFE界面)可以具有增强的密封性能和/或滑动性能。可以设想,基于两种相似材料之间的表面能,密封界面702的这种构造可以具有较低的泄漏可能性。
申请人W.L.戈尔同仁公司的美国专利5,772,755提供了屏障242和针筒20(例如,由硼硅酸盐玻璃制成)之间的这种转移机制的可行性的证据。例如,该专利参考文献描述了涂覆玻璃板以生产定向PTFE。具体地,将玻璃板放置在平台上并通过辐射热加热至200℃的温度。通过润滑(糊状)挤出凝结分散型PTFE、蒸发润滑剂、并且以2:1拉伸挤出的带以使带柔顺来制备PTFE带。将该带围绕约14英寸长的可加热棒缠绕。然后将被缠绕的棒加热至约300℃,然后用可调节的力将棒拖过玻璃基材。进行多次以确保玻璃表面的完全覆盖。通过拖动PTFE棒,PTFE以对准的PTFE链的多个行沉积在玻璃表面上。
可以设想,与上述机制类似,屏障242和针筒20之间的相对运动将导致材料(例如,PTFE或ePTFE)的一些加热和转移,其定向对应于相对运动的方向(例如,周向的、纵向的或它们的组合),这取决于特定的实施方式。
因此,在各种示例中,注入器装置10、100包括限定密封界面的针筒和止挡件,针筒具有对应于屏障的材料的沉积的材料,该沉积的材料具有方向性定向。例如,材料的方向性定向可以例如由沿共同方向对准的PTFE链的多个行限定。共同方向可以是周向方向、纵向方向或其组合。图19A和19B示出了与图18A和18B类似的原理,但是相对于更一般的管状构件5300,管状构件5300可以是通气管4264或其他管状构件。如前所述,止挡件40的外侧244可以包括聚合物材料(例如,FEP、ePTFE、PTFE和/或本文描述的另一种聚合物材料)。并且,修改止挡件40包括在止挡件40和管状构件5300之间的界面处引发聚合物材料的聚合物运动。可以设想,止挡件40的表面,具体地是屏障242,可以包括一个或多个褶皱或表面缺陷900。同样地,这样的表面缺陷900可以在制造期间产生或以其他方式产生。通过引发止挡件和管状构件5300之间的相对运动来修改注射器止挡件40可能导致屏障242的材料的聚合物运动,从而使表面缺陷或褶皱变平滑。这又可以帮助使止挡件40的外侧244与针筒20的内表面124更加适形(在止挡件40被组装到针筒20中之后,或者在止挡件40被组装到针筒20中之后)。这又可以导致止挡件40的外表面244的粗糙度减小。如前所述,能够以周向图案(例如,通过连续的、振荡的或其他相对旋转)将表面修改应用于止挡件以帮助增强密封完整性。
示例材料组
针筒20可由基本上刚性或硬质的材料形成,诸如玻璃材料(例如硼硅酸盐玻璃)、陶瓷材料、一种或多种聚合物材料(例如聚丙烯、聚乙烯及其共聚物)、金属材料或塑料材料(例如环烯烃聚合物(COC)和环烯烃共聚物(COP),及其组合。应当理解,由本质上不疏水的材料形成的筒(例如玻璃筒)可以被涂覆或以其他方式处理以使其具有疏水性。在一些实施例中,针筒20具有疏水性内部壁,其特征在于不存在润滑剂,诸如但不限于硅酮或硅油。如本文所用,术语“疏水性内部壁”是指不含或基本上不含(即,具有不可计量的量的或痕量的)硅油的针筒的内表面。此外,针筒20的疏水表面还具有去离子水在材料平坦表面上的大于90°的接触角,表明为疏水表面。在一些实施例中,水接触角为从约90°至约180°、或从约96°至约180°、从约96°至约130°、或从约96°至约120°。
在一些实施例中,止挡件40的本体240由合适的弹性体形成,诸如橡胶材料。合适的橡胶材料的示例包括合成橡胶、热塑性弹性体以及通过共混合成橡胶和热塑性弹性体制备的材料。该材料可以是由丁基、溴丁基或氯丁基、卤化丁基橡胶、苯乙烯丁二烯橡胶、丁二烯橡胶、表氯醇橡胶、氯丁橡胶、乙烯丙烯橡胶、硅酮、丁腈、苯乙烯丁二烯、聚氯丁二烯橡胶、三元乙丙、含氟弹性体、热塑性弹性体(TPE)、热塑性硫化橡胶(TPV)、以商品名销售的材料及其组合物和共混物构成的橡胶。在一些实施例中,本体240可具有约2.5MPa至约5MPa之间或约3MPa至约4MPa之间的初始模量(小应变)。在一些实施例中,初始模量为约3.5MPa,但是设想了多种值。
如前所述,屏障242的部分(例如,层或区域)可以构造成比屏障242的其他层或区域更容易由能量源激活或对能量源更具反应性。例如,在激光或其他光能量源的情况下,反应性或被激活的能力可以通过改变材料厚度、色素沉着、密度/开放空间/空气含量、化学/材料成分等来调节。在射频(RF)、电和电磁能量源的情况下,屏障242可以被调节为包括颜料或其他填料,诸如金属(例如,铁、铂或其他),其对这种能量更具反应性。在微波能量源的情况下,可以实施金属、水或其他材料。并且,在紫外线(UV)能量的情况下,可以加入交联剂(会交联并增加密度/刚度的丙烯酸酯)或吸收紫外线能量的其他材料。
用于止挡件的屏障242的一层或多层的合适材料的示例包括超高分子量聚乙烯和氟树脂的薄膜。屏障242可包括含氟聚合物薄膜,诸如聚四氟乙烯(PTFE)薄膜或致密膨胀型聚四氟乙烯(ePTFE)薄膜。包含PTFE或ePTFE的薄膜和薄膜复合材料可有助于为可浸出物和可萃取物提供薄而坚固的屏障,这些可浸出物和可萃取物可能存在于位于下方的弹性体中,并且在其他情况下可能会污染针筒中的治疗物质。
屏障242的合适材料的一些具体示例包括但不限于以下:(1)通过刮削方法生产的PTFE(聚四氟乙烯)均聚物薄膜(例如,可从日本华尔卡株式会社(Nippon ValquaIndustries)有限公司获得的VALFLON(商品名));(2)通过刮削法制造的改性PTFE(四氟乙烯单体与百分之几的全氟醇盐单体的共聚物)薄膜(例如,可从日本华尔卡株式会社有限公司获得的NEW VALFLON(商品名));以及(3)通过刮削法制造的超高分子量聚乙烯薄膜(例如,可从Saxin公司获得的NEW LIGHT NL-W(商品名))。
如所指示的,屏障242可以是复合材料或层合材料,或者在其他情况下包括多部件(例如,多层)屏障。用于屏障242中或用作屏障242的其他合适的含氟聚合物包括但不限于氟化乙烯丙烯(FEP)、聚偏二氟乙烯、聚氟乙烯、全氟丙基乙烯基醚、全氟烷氧基聚合物、四氟乙烯(TFE)、聚对二甲苯AF-4、聚对二甲苯VT-4及其共聚物和组合物。非含氟聚合物,诸如但不限于聚乙烯、聚丙烯、聚对二甲苯C和聚对二甲苯N也可以或替代地用于形成屏障242。
用于屏障242的致密ePTFE薄膜可以按照授予Kennedy等人的美国专利第7,521,010号、授予Dolan等人的美国专利第6,030,694号、授予Fuhr等人的美国专利第5,792,525号或授予Knox等人的美国专利第5,374,473号中描述的方式制备。PTFE的膨胀共聚物也可用于屏障242,诸如授予Branca的美国专利第5,708,044号、授予Baillie的美国专利第6,541,589号、授予Sabol等人的美国专利第7,531,611号、授予Ford的美国专利第8,637,144号、以及授予Xu等人的美国专利第9,139,669号中描述的那些,特别是如果它们是致密的。
在一个或多个实施例中,屏障242可包括以下材料中的一种或多种,或者由以下材料中的一种或多种形成:超高分子量聚乙烯,如授予Sbriglia的美国专利第9,926,416号中所教导的;聚对二甲苯,如Sbriglia的美国专利公开第2016/0032069号中所教导的;聚乳酸,如授予Sbriglia等人的美国专利第9,732,184号中所教导的;和/或VDF-co-(TFE或TrFE)聚合物,如授予Sbriglia的美国专利第9,441,088号中教导的。
屏障242还可以包括膨胀型聚合物材料,该膨胀型聚合物材料包括功能性四氟乙烯(TFE)共聚物材料,该材料具有以由原纤维互连的节点为特征的微结构,其中,功能性TFE共聚物材料包括TFE和PSVE(全氟磺酰基乙烯基醚)的功能性共聚物,或者TFE与另一种合适的功能性单体,诸如但不限于偏二氟乙烯(VDF)、乙酸乙烯酯或乙烯醇。功能性TFE共聚物材料可以例如根据授予Xu等人的美国专利第9,139,669号或授予Xu等人的美国专利第8,658,707号中描述的方法来制备。
在一些实施例中,屏障242可由具有屏障层和粘结层(联系层)的复合含氟聚合物或非含氟聚合物材料形成,诸如Gunzel的美国专利公开第2016/0022918号中所描述的。应当注意的是,如本文所使用的,术语“粘结层”可以包括含氟聚合物和/或非含氟聚合物材料。粘结层可包括膨胀型聚四氟乙烯或其他多孔膨胀型含氟聚合物(例如,授予Baille的美国专利第6,541,589号中教导的ePTFE),或由膨胀型聚四氟乙烯或其他多孔膨胀型含氟聚合物形成。或者,粘结层可以由非含氟聚合物材料形成或包括非含氟聚合物材料。用于或用作粘结层的合适的非含氟聚合物材料的非限制性示例包括非含氟聚合物隔膜、非含氟聚合物微孔隔膜、非织造材料(例如,纺粘、熔喷纤维材料、电纺纳米纤维)、聚偏二氟乙烯(PVDF)、纳米纤维、聚砜、聚醚砜、聚芳基砜、聚醚醚酮(PEEK)、聚乙烯、聚丙烯和聚酰亚胺。
在一些实施例中,屏障242可以通过形成包括多孔ePTFE层和热塑性屏障层的薄致密复合材料来制成。在这方面,优选的是具有低摩擦系数表面的热塑性塑料。因此,可应用基于含氟聚合物的热塑性塑料,诸如氟化乙烯丙烯(FEP)、全氟烷氧基(PFA)、四氟乙烯、六氟丙烯和偏二氟乙烯的聚合物(THV)。根据该方面的屏障可以是通过遵循Bacino的WO 94/13469中教导的方法获得的FEP/ePTFE层合物。屏障可以在高于软化温度或者甚至高于凹形空腔模具中FEP薄膜的熔融物的加工温度下形成。
在一些实施例中,屏障242可包括致密ePTFE薄膜和结合至屏障层薄膜的多孔ePTFE薄层的复合物。致密的ePTFE薄膜可以如授予Kennedy等人的美国专利第4,750,407号中所述获得。ePTFE/致密ePTFE复合物能够以授予Dolan等人的美国专利第6,030,694号中描述的方式组合。在该实施例中,复合材料包括致密ePTFE薄膜和多孔ePTFE层。
在一些实施例中,屏障242包括具有至少三个层的复合材料,即致密膨胀含氟聚合物层、屏障熔融含氟聚合物层和多孔层。致密膨胀含氟聚合物层可包括致密ePTFE或由致密ePTFE形成。屏障熔融含氟聚合物层可包括含氟聚合物,诸如致密膨胀型含氟聚合物、聚四氟乙烯(PTFE)、膨胀型聚四氟乙烯(ePTFE)、致密膨胀型聚四氟乙烯、氟化乙烯丙烯(FEP)、聚偏二氟乙烯、聚氟乙烯、全氟丙基乙烯基醚、全氟烷氧基聚合物、以及其共聚物和组合物。可用于屏障熔融层的非含氟聚合物的非限制性示例包括聚乙烯和聚丙烯。多孔层可包括ePTFE或其他多孔膨胀含氟聚合物,或由ePTFE或其他多孔膨胀含氟聚合物形成。具有致密膨胀含氟聚合物层、屏障熔融含氟聚合物层和多孔层的层合层可通过将致密膨胀含氟聚合物涂覆或以其他方式沉积到多孔层上以产生复合材料来构造。在一非限制性实施例中,层合层由致密含氟聚合物(例如,致密ePTFE)、热塑性粘合剂(例如,FEP)和多孔含氟聚合物(例如,ePTFE)形成。
应当理解,止挡件40可以包括本体240的材料进入屏障242的材料中的各种程度的渗透;或者,反之亦然,包括在授予Ashmead等人的美国专利第8,722,178号、授予Ashmead等人的美国专利第9,597,458号、以及Gunzel的美国专利公开第2016/0022918号中描述的那些。还应当理解,在不脱离本发明的范围和/或精神的情况下,可以利用本文描述的方法(工艺)的许多变型来形成止挡件40。
治疗物质的示例
本公开的注射器、端盖和其他实施例可以与不同的治疗化合物组合使用,治疗化合物包括但不限于药物和生物制剂,诸如凝血因子、细胞因子、表观遗传蛋白家族、生长因子、激素、肽、信号转导分子及其突变;还包括氨基酸、疫苗和/或其组合。治疗化合物还包括针对上述生物制剂及其靶受体及其突变的抗体、反义、RNA干扰。其他治疗化合物包括基因疗法、原代干细胞和胚胎干细胞。治疗化合物中还包括对蛋白激酶、酯酶、磷酸酶、离子通道、蛋白酶、结构蛋白、膜转运蛋白、核激素受体和/或其组合的抗体、反义、RNA干扰。此外,应当理解,在本公开中使用的本文所指明的至少一种治疗化合物以及本申请中列出的两种或更多种治疗化合物被认为在本公开的范围内。
凝血因子的示例包括但不限于:纤维蛋白原、凝血酶原、因子I、因子V、因子X、因子VII、因子VIII、因子XI、因子XIII、蛋白C、血小板、凝血致活酶和VIIa的辅因子。
细胞因子的示例包括但不限于:淋巴因子、白细胞介素、趋化因子、单核因子、干扰素和集落刺激因子。
表观遗传蛋白家族的示例包括但不限于:含ATP酶家族AAA结构域的蛋白2(ATAD2A)、含ATP酶家族-AAA结构域的2B(ATAD2B)、含ATP酶家族AAA结构域的-2B(ATAD2B)、与锌指结构域相邻的溴结构域-1A(BAZ1A)、与锌指结构域相邻的溴结构域-1B(BAZ1B)、与锌指结构域相邻的溴结构域-2A(BAZ2A)、与锌指结构域相邻的溴结构域-2A(BAZ2A)、与锌指结构域相邻的溴结构域-2B(BAZ2B)、含溴结构域的蛋白1(BRD1)、含溴结构域的蛋白2-第1溴结构域(BRD2)、含溴结构域的蛋白2-第1和第2溴结构域(BRD2)、含溴结构域的蛋白2同源异构体1-溴结构域2(BRD2(2))、含溴结构域的蛋白3-溴结构域1(BRD3(1))、含溴结构域的蛋白3-第1溴结构域(BRD3)、含溴结构域的蛋白3-第1和第2溴结构域(BRD3)、含溴结构域的蛋白3-溴结构域2(BRD3(2))、含溴结构域的蛋白4-第1溴结构域(BRD4)、含溴结构域的蛋白4同源异构体长-溴结构域1和2(BRD4(1-2))、含溴结构域的蛋白4同源异构体长-溴结构域2(BRD4(2))、含溴结构域的蛋白4同源异构体型短(BRD4(全长-短-异))、含溴结构域的蛋白7(BRD7)、含溴结构域的8-溴结构域1(BRD8(1))、含溴结构域的8-溴结构域2(BRD8(2))、含溴结构域的蛋白9同源异构体1(BRD9)、含溴结构域的睾丸特异性-第1溴结构域(BRDT)、含溴结构域的睾丸特异性-第1和第2溴结构域(BRDT)、溴结构域睾丸特异性蛋白同源异构体b-溴结构域2(BRDT(2))、含溴结构域和PHD指的-1(BRPF1)、含溴结构域和PHD指的-3(BRPF3)、含溴结构域和PHD指的-3(BRPF3)、含溴结构域和WD重复的3–第2溴结构域(BRWD3(2))、猫眼综合征临界区蛋白2(CECR2)、CREB结合蛋白(CREBBP)、E1A结合蛋白p300)(EP300)、EP300(EP300)、核小体-重塑因子亚基BPTF同源异构体1(FALZ))、核小体-重塑因子亚基BPT(FALZ)、常染色质组蛋白(Euchromatichistone)-赖氨酸N-甲基转移酶2(EHMT2)、组蛋白乙酰转移酶-KAT2A(GCN5L2)、常染色质组蛋白-赖氨酸N-甲基转移酶1(EHMT1)、组蛋白-赖氨酸N-甲基转移酶MLL(MLL)、多溴1-第1溴结构域(PB1(1))、多溴1-第2溴结构域(PB1(2))、多溴1-溴结构域2(PBRM1(2))、多溴1-溴结构域5(PBRM1(5))、组蛋白乙酰转移酶KAT2B(PCAF)、PH-相互作用蛋白-第1溴结构域(PHIP(1))、PH-相互作用蛋白-第2溴结构域(PHIP(2))、蛋白激酶C-结合蛋白1(PRKCBP1)、蛋白精氨酸N-甲基转移酶3(PRMT3)、SWI/SNF相关-基质相关-肌动蛋白依赖性染色质调节因子-亚家族a-成员2(SMARCA2)、SWI/SNF相关-基质相关-肌动蛋白依赖性染色质调节因子-亚家族a-成员4(SMARCA4)、核体蛋白-SP110(SP110)、核体蛋白-SP140(SP140)、转录起始因子TFIID亚基1(TAF1(1-2))、TAF1RNA聚合酶II-TATA盒结合蛋白(TBP)-相关因子-250kDa-溴结构域2(TAF1(2))、转录起始因子TFIID亚基1-样-第1溴结构域(TAF1L(1)),转录起始因子TFIID亚基1-样-第2溴结构域(TAF1L(2))、含三结构域蛋白家族24(TRIM24(溴))、含三结构域家族蛋白24(TRIM24(PHD-溴))、E3泛素-蛋白连接酶TRIM33(TRIM33)、含三结构域蛋白家族的33(TRIM33(PHD-溴))、WD重复9-第1溴结构域(WDR9(1))、和WD重复9-第2溴结构域(WDR9(2))。
生长因子的示例包括但不限于:神经生长因子(NGF)、血管内皮生长因子(VEGF)、血小板衍生生长因子(PDGF)、C-fos诱导生长因子(FIGF)、血小板活化因子(PAF)、转化生长因子β(TGF-β)、骨形态发生蛋白(BMP)、激活素、抑制素、成纤维细胞生长因子(FGF)、粒细胞集落刺激因子(G-CSF)、粒细胞巨噬细胞集落刺激因子(GM-CSF)、神经胶质细胞源性神经营养因子(GDNF)、生长分化因子9(GDF9)、表皮生长因子(EGF)、转化生长因子-α(TGF-α)、生长因子(KGF)、迁移刺激因子(MSF)、肝细胞生长因子样蛋白(HGFLP)、肝细胞生长因子(HGF)、肝癌衍生生长因子(HDGF)、以及胰岛素样生长因子。
激素的示例包括但不限于:氨基酸衍生的(如褪黑素和甲状腺素)、促甲状腺素释放激素、加压素、胰岛素、生长激素、糖蛋白激素、促黄体激素、促卵泡激素、促甲状腺激素、类二十烷酸、花生四烯酸、脂氧素、前列腺素、类固醇、雌激素、睾酮、皮质醇、和孕激素。
蛋白质和肽以及信号转导分子的示例包括但不限于:共济失调性毛细血管扩张突变、肿瘤蛋白p53、检查点激酶2、乳腺癌易感性蛋白、双链断裂修复蛋白、DNA修复蛋白RAD50、尼布林(Nibrin)、p53-结合蛋白、DNA损伤检查点蛋白的介体、H2A组蛋白家族成员X、小脑磷脂、C末端结合蛋白1、染色体结构维持蛋白1A、细胞分裂周期25同源物A(CDC25A)、叉头盒O3(叉头盒O3)、B细胞抑制剂中kappa轻链多肽基因增强子的核因子、α(NFKBIA)、核因子(红细胞衍生2)样2(NFE2L2)、利钠肽受体A(NPR1)、肿瘤坏死因子受体超家族、成员11a(TNFRSF11A)、v-rel禽网状内皮组织增殖病毒癌基因同源物A(禽类)(RELA)、甾醇调节元件结合转录因子2(SREBF2)、CREB调节转录共激活因子1(CRTC1)、CREB调节转录共激活因子2(CRTC2)、X-盒结合蛋白1(XBP1)和连环蛋白β1(钙粘蛋白相关蛋白或CTNNB1)。
G蛋白偶联受体(GPCR)的示例包括但不限于:腺苷受体家族、肾上腺素受体家族、血管紧张素II受体、爱佩琳(Apelin)受体、血管加压素受体家族、脑特异性血管生成抑制剂家族、缓激肽受体家族、铃蟾肽受体家族、补体成分3a受体1、补体成分5a受体1、降钙素受体家族、降钙素受体样家族、钙敏感受体、胆囊收缩素A受体(CCK1)、胆囊收缩素B受体(CCK2)、趋化因子(C-C基序)受体家族、鞘氨醇1-磷酸受体家族、琥珀酸受体、胆碱能受体家族。趋化因子样受体家族、大麻素受体家族、促肾上腺皮质激素释放激素受体家族、前列腺素D2受体、趋化因子C-X3-C受体家族、趋化因子(C-X-C基序)受体家族、伯基特淋巴瘤受体、趋化因子(C-X-C基序)受体家族、半胱氨酰白三烯受体2(CYSLT2)、趋化因子受体(FY)、多巴胺受体家族、G蛋白偶联受体183(GPR183)、溶血磷脂酸受体家族、内皮素受体家族、凝血因子II(凝血酶)受体家族、游离脂肪酸受体家族、甲酰肽受体家族、卵泡刺激素受体(FSHR)、γ-氨基丁酸(GABA)B受体、甘丙肽受体家族、胰高血糖素受体、生长激素释放激素受体(GHRH)、胃生长激素促分泌素受体(ghrelin)、生长激素促分泌素受体1b(GHSR1b)、胃抑制多肽受体(GIP)、胰高血糖素样肽受体家族、促性腺激素释放激素受体(GnRH)、焦谷氨酰化(pyrogluta mylated)RF酰胺肽受体(QRFPR)、G蛋白偶联胆汁酸受体1(GPBA)、羟基羧酸受体家族、溶血磷脂酸受体4(LPA4)、溶血磷脂酸受体5(GPR92)、G蛋白偶联受体79假基因(GPR79)、羟基羧酸受体1(HCA1)、G蛋白偶联受体((C5L2、FFA4、FFA4、FFA4、GPER、GPR1、GPR101、GPR107、GPR119、GPR12、GPR123、GPR132、GPR135、GPR139、GPR141、GPR142、GPR143、GPR146、GPR148、GPR149、GPR15、GPR150、GPR151、GPR152、GPR157、GPR161、GPR162、GPR17、GPR171、GPR173、GPR176、GPR18、GPR182、GPR20、GPR22、GPR25、GPR26、GPR27、GPR3、GPR31、GPR32、GPR35、GPR37L1、GPR39、GPR4、GPR45、GPR50、GPR52、GPR55、GPR6、GPR61、GPR65、GPR75、GPR78、GPR83、GPR84、GPR85、GPR88、GPR97、TM7SF1)、代谢型谷氨酸受体家族、促胃液素释放肽受体(BB2)、食欲素受体家族、组胺受体家族、5-羟色胺受体家族、KISS1衍生肽受体(亲吻促动素(kisspeptin))、含富亮氨酸重复的G蛋白偶联受体家族、绒毛膜促性腺激素受体(LH)、白三烯B4受体(BLT1)、腺苷酸环化酶激活多肽1受体1(mPAC1)、胃动素受体、黑皮质素受体家族、黑色素浓缩激素受体1(MCH1)、神经肽Y1受体(Y1)、神经肽Y2受体(NPY2R)、阿片受体家族、催产素受体(OT)、P2Y嘌呤受体12(mP2Y12)、P2Y嘌呤受体6(P2Y6)、胰多肽受体家族、血小板活化因子受体家族、前列腺素E受体家族、前列腺素类IP1受体(IP1)、MAS相关GPR、成员家族、视紫红质(Rhodopsin)、松弛素家族肽受体家族、生长抑素受体家族、速激肽受体家族、褪黑素受体家族、尾紧张肽受体家族、血管活性肠肽受体1(mVPAC1)、神经调节肽B受体(BB1)、神经调节肽U受体1(NMU1)、神经肽B/W受体家族、神经肽FF受体1(NPFF1)、神经肽S受体1(NPS受体)、神经肽Y受体家族、神经降压素受体1(NTS1)、视蛋白5(OPN5)、阿片类受体样受体(NOP)、氧桥二十烷类(OXE)受体1(OXE)、氧代戊二酸(α-酮戊二酸)受体1(OXGR1)、嘌呤能受体家族、嘧啶能受体家族、催乳素释放激素受体(PRRP)、前动力蛋白受体家族、血小板活化受体(PAF)、前列腺素F受体家族、前列腺素I2(前列环素)受体家族、甲状旁腺激素受体家族、毒蕈碱样乙酰胆碱受体(诸如rM4)、前列腺素DP2受体(rGPR44)、前动力蛋白受体家族、松弛素家族肽受体家族、分泌素受体(促胰液素)、卷曲类受体(Smoothened(平滑受体))、微量胺相关受体家族、速激肽家族、血栓素A2受体(TP)、促甲状腺激素释放激素受体(TRH1)、和甲状腺刺激素受体(TSH)。
核激素受体的示例包括但不限于:雄激素受体(AR)、雌激素相关受体α(ESRRA)、雌激素受体1(ESR1)、核受体亚家族1-组H-成员4(NR1H4)、核受体亚家族3-组C-成员1(糖皮质激素受体)(NR3C1)、核受体亚家族1-组H-成员3(肝X受体α)(NR1H3)、核受体亚家族1-H组-成员2(肝X受体β)(NR1H2)、核受体亚家族1-组H-成员2(肝X受体β)(NR1H2)、核受体亚家族3-组C-成员2(盐皮质激素受体)(NR3C2)、过氧化物酶体增殖物激活受体α(PPARA)、过氧化物酶体增殖物激活受体γ(PPARG)、过氧化物酶体增殖物激活受体δ(PPARD)、孕酮受体α(PGR)、孕酮受体β(PGR)、视黄酸受体-α(RARA)、视黄酸受体-β(RARB)、视黄醇X受体-α(RXRA)、视黄醇X受体-γ(RXRG)、甲状腺激素受体-α(THRA)、甲状腺激素受体-β(THRB)、视黄酸相关孤儿受体、肝X受体、法尼醇X受体、维生素D受体、孕烷X受体、组成型雄甾烷受体、肝细胞核因子4、雌激素受体、雌激素相关受体、糖皮质激素受体、以及神经生长因子诱导的B、生殖细胞核因子。
膜转运蛋白的示例包括但不限于:ATP结合盒(ABC)超家族、溶质载体(SLC)超家族、多药耐药蛋白1(P-糖蛋白)、有机阴离子转运蛋白1、和蛋白质,诸如:EAAT3、EAAC1、EAAT1、GLUT1、GLUT2、GLUT9、GLUT10、rBAT、AE1、NBC1、KNBC、CHED2、BTR1、NABC1、CDPD、SGLT1、SGLT2、NIS、CHT1、NET、DAT、GLYT2、CRTR、BOAT1、SIT1、XT3、y+LAT1、BAT1、NHERF1、NHE6、ASBT、DMT1、DCT1、NRAMP2、NKCC2、NCC、KCC3、NACT、MCT1、MCT8、MCT12、SLD、VGLUT3、THTR1、THTR2、PIT2、GLVR2、OCTN2、URAT1、NCKX1、NCKX5、CIC、PiC、ANTI、ORNT1、AGC1、ARALAR、希特林(Citrin)、STLN2、aralar2、TPC、MUP1、MCPHA、CACT、GC1、PHC、DTD、CLD、DRA、PDS、动力蛋白(Prestin)、TAT1、FATP4、ENT3、ZnT2、ZnT10、AT1、NPT2A、NPT2B、HHRH、CST、CDG2F、UGAT、UGTL、UGALT、UGT1、UGT2、FUCT1、CDG2C、NST、PAT2、G6PT1、SPX4、ZIP4、LIV4、ZIP13、LZT-Hs9、FPN1、MTP1、IREG1、RHAG、AIM1、PCFT、FLVCR1、FLVCR2、RFT1、RFT2、RFT3、OATP1B1、OATP1B3和OATP2A1。
结构蛋白的示例包括但不限于:微管蛋白、热休克蛋白、微管稳定蛋白、癌蛋白18、微管不稳定蛋白、驱动蛋白8和驱动蛋白14家族、Kip3和Kif18A。
蛋白酶的示例包括但不限于ADAM(解整合素和金属蛋白酶)家族。
蛋白激酶的示例包括但不限于:AP2相关激酶、智人ABL原癌基因1-非受体酪氨酸-蛋白激酶家族、c-abl致癌基因1受体酪氨酸激酶家族、v-abl阿贝尔森鼠白血病病毒致癌基因同源物2、激活素A受体家族、伴侣蛋白-bc1复合物同源物(S.pombe)的ABC1活性(ADCK3)、含aarF结构域激酶4(ADCK4)、v-akt鼠胸腺瘤病毒致癌基因同源物家族、间变性淋巴瘤受体酪氨酸激酶家族、蛋白激酶A家族、蛋白激酶B家族、含有锚蛋白重复和激酶结构域的1(ANKK1)、NUAK家族-SNF1样激酶、丝裂原活化蛋白激酶激酶激酶家族极光激酶(aurorakinase)A(AURKA)、极光激酶B(AURKB)、极光激酶C(AURKC)、AXL受体酪氨酸激酶(AXL)、BMP2诱导型激酶(BIKE)、B淋巴酪氨酸激酶(BLK)、骨形态发生蛋白受体家族、BMX非受体酪氨酸激酶(BMX)、v-raf鼠肉瘤病毒致癌基因同源物B1(BRAF)、蛋白酪氨酸激酶6(BRK)、BR丝氨酸/苏氨酸激酶家族、布鲁顿无丙种球蛋白血症酪氨酸激酶(BTK)、钙/钙调素依赖蛋白激酶家族、细胞周期蛋白依赖性激酶家族、细胞周期蛋白依赖性激酶样家族、CHK1检查点同源物(S.pombe)(CHEK1)、CHK2检查点同源物(S.pombe)(CHEK2)、胰岛素受体、同源异构体A(INSR)、胰岛素受体、同源异构体B(INSR)、rho-相互作用丝氨酸/苏氨酸激酶(CIT)、v-kit哈地-朱克曼4猫肉瘤病毒致癌基因同源物(KIT)、CDC样激酶家族-肝细胞生长因子受体(MET)、原癌基因酪氨酸蛋白激酶受体、集落刺激因子家族受体、c-src酪氨酸激酶(CSK)、酪蛋白激酶家族、巨核细胞相关酪氨酸激酶(CTK)、死亡相关蛋白激酶家族、双皮质激素家族、盘状蛋白结构域受体酪氨酸激酶、营养不良肌强直蛋白-蛋白激酶(DMPK)、双特异性酪氨酸-(Y)-磷酸化调节激酶家族、表皮生长因子受体家族、真核翻译起始因子2-α激酶1(EIF2AK1)、EPH受体家族、肝配蛋白A型受体家族、肝配蛋白B型受体家族、v-erb-b2成红细胞白血病病毒致癌基因同源家族、丝裂原-激活的蛋白激酶家族、内质网到核信号传导1(ERN1)、PTK2蛋白酪氨酸激酶2(FAK)、fer(fps/fes相关)酪氨酸激酶(FER)。猫肉瘤基因(FES)、成纤维细胞生长因子受体家族、加德纳-拉希德猫肉瘤病毒(v-fgr)致癌基因同源物(FGR)、fms相关酪氨酸激酶家族、Fms相关酪氨酸激酶家族、fyn相关激酶(FRK)、与SRC相关的FYN癌基因、细胞周期蛋白G相关激酶(GAK)、真核翻译起始因子2α激酶、生长激素受体。G蛋白偶联受体激酶1(GRK1)、G蛋白偶联受体激酶家族、糖原合成酶激酶家族、生殖细胞相关的2(单倍体生殖细胞特异性核蛋白激酶)(HASPIN)、造血细胞激酶(HCK)、同源域相互作用蛋白激酶家族、有丝分裂原-活化蛋白激酶激酶激酶激酶家族、激素上调Neu相关激酶(HUNK)、肠细胞(MAK样)激酶(ICK)、胰岛素样生长因子1受体(IGF1R)、保守的螺旋-环-螺旋普遍存在激酶(IKK-α)、B细胞中κ轻链多肽基因增强子抑制剂-激酶β家族、胰岛素受体(INSR)、胰岛素受体相关受体(INSRR)、白细胞介素-1受体相关激酶家族、IL2诱导型T细胞激酶(ITK)、Janus激酶家族、激酶插入域受体、v-kit哈地-朱克曼4猫肉瘤病毒致癌基因同源物、淋巴细胞特异性蛋白酪氨酸激酶(LCK)、LIM结构域激酶家族、丝氨酸/苏氨酸激酶家族富含亮氨酸重复序列激酶家族、v-yes-1山口肉瘤病毒相关致癌基因同源物(LYN)、雄性生殖细胞相关激酶(MAK);MAP/微管亲和调节激酶家族,诸如微管相关丝氨酸/苏氨酸激酶家族、母体胚胎亮氨酸拉链激酶、c-mer原癌基因酪氨酸激酶(MERTK)、met原癌基因(肝细胞生长因子受体)、MAP激酶相互作用丝氨酸/苏氨酸激酶家族、肌球蛋白轻链激酶家族、混合谱系激酶结构域样蛋白同源异构体、CDC42结合蛋白激酶家族、丝氨酸/苏氨酸激酶家族、巨噬细胞刺激1受体(c-met相关酪氨酸激酶)(MST1R)、雷帕霉素(丝氨酸/苏氨酸激酶)(MTOR)的机制靶点激酶、肌肉-骨骼-受体酪氨酸激酶(MUSK)、肌球蛋白轻链激酶家族、NIMA(从未在有丝分裂基因a中)相关激酶家族、丝氨酸/苏氨酸蛋白激酶NIM1(NIM1)、nemo样激酶(NLK)、氧化应激反应1(OSR1)、p21蛋白(Cdc42/Rac))激活的激酶家族、含有PAS结构域的丝氨酸/苏氨酸激酶、血小板衍生生长因子受体家族、3-磷酸肌醇依赖性蛋白激酶-1(PDPK1)、钙依赖性蛋白激酶1、磷酸化酶激酶γ家族、磷脂酰肌醇4,5-二磷酸3-激酶、磷酸肌醇-3-激酶家族、磷脂酰肌醇4-激酶家族。磷酸肌醇激酶、含有FYVE指、Pim-1致癌基因(PIM1)、pim-2致癌基因(PIM2)、pim-3致癌基因(PIM3)、磷脂酰肌醇-4-磷酸5-激酶家族、磷脂酰肌醇-5-磷酸4-激酶家族蛋白激酶、膜相关酪氨酸/苏氨酸1(PKMYT1)、蛋白激酶N家族、polo样激酶家族、蛋白激酶C家族、蛋白激酶D家族、cGMP依赖性蛋白激酶家族、真核翻译起始因子2-α激酶2(PRKR)、X连锁蛋白激酶(PRKX)、催乳素受体(PRLR)、PRP4前mRNA加工因子4同源物B(酵母)(PRP4)、PTK2B蛋白酪氨酸激酶2β(PTK2B)、SIK家族激酶3(QSK)、v-raf-1鼠白血病病毒致癌基因同源物1(RAF1)、神经营养酪氨酸激酶受体类型家族、受体(TNFRSF)-相互作用的丝氨酸-苏氨酸激酶家族、双丝氨酸/苏氨酸和酪氨酸蛋白激酶(RIPK5)、Rho-相关的、含有卷曲螺旋的蛋白激酶家族、c-ros癌基因1、受体酪氨酸激酶(ROS1)、核糖体蛋白S6激酶家族、SH3结合域激酶1(SBK1)、血清/糖皮质激素调节激酶家族、推定的非特征性丝氨酸/苏氨酸蛋白激酶(Sugen激酶110)(SgK110)、盐诱导型激酶家族、SNF相关激酶(SNRK)、src相关激酶、SFRS蛋白激酶家族、脾酪氨酸激酶(SYK),诸如TAO激酶家族;TANK结合激酶1(TBK1),诸如tec蛋白酪氨酸激酶(TEC)、睾丸特异性激酶1(TESK1)、转化生长因子、β受体家族、酪氨酸激酶与免疫球蛋白样和EGF样结构域1(TIE1)、TEK酪氨酸激酶、内皮细胞(TIE2)、血管生成素-1受体(Tie2)、凌乱样激酶家族、TRAF2和NCK相互作用激酶(TN IK)、非受体酪氨酸激酶家族、TNNI3相互作用激酶(TNNI3K)、瞬时受体电位阳离子通道、睾丸特异性丝氨酸激酶家族、TTK蛋白激酶(TTK)、TXK酪氨酸激酶(TXK)、酪氨酸激酶2(TYK2)、TYRO3蛋白酪氨酸激酶(TYRO3)、unc-51样激酶家族、磷脂酰肌醇3-激酶、牛痘相关激酶2(VRK2)、WEE1同源物家族、WNK赖氨酸缺乏蛋白激酶家族、v-yes-1山口肉瘤病毒致癌基因同源物1(YES)、含有无菌α基序和亮氨酸拉链的激酶AZK(ZAK)和ζ-链(TCR)相关蛋白激酶70kDa(ZAP70)。
细胞疗法所使用的细胞主要来源于如下细胞的:内胚层,如外分泌部上皮细胞(Exocrine secretory epithelial cell)和激素分泌细胞;外胚层,如角质化上皮细胞、湿分层屏障上皮细胞、感觉转导细胞、自主神经细胞、感觉器官和外周神经元支持细胞、中枢神经系统神经元和神经胶质细胞、晶状体细胞;中胚层,例如代谢和储存细胞,屏障功能细胞(肺、肠、外分泌腺和泌尿生殖道)、细胞外基质细胞、收缩细胞、血液和免疫系统细胞、生殖细胞、滋养细胞、间质细胞和它们的组合。此外,经遗传、化学、或物理改变或以其他方式修饰的细胞在本发明的范围内。
外分泌部上皮细胞的示例包括但不限于:唾液腺粘液细胞、1号唾液腺、舌中的冯哎波讷腺细胞、乳腺细胞、泪腺细胞,耳中的耵聍腺细胞、外分泌汗腺暗细胞、外分泌汗腺亮细胞、顶泌汗腺细胞、眼睑的墨氏腺细胞、皮脂腺细胞、鼻的鲍曼氏腺细胞、十二指肠的步伦纳腺细胞、精液泡细胞、前列腺细胞、尿道球部腺细胞、巴多林氏腺细胞、尿道腺细胞、子宫内膜细胞、呼吸道和消化道的孤立杯状细胞、胃膜粘液细胞、胃腺酶源细胞、胃腺泌酸细胞、胰腺腺泡细胞、小肠的潘氏细胞、肺II型肺细胞、以及肺的克拉拉细胞;激素分泌细胞包括但不限于:脑垂体前部细胞、脑垂体中叶细胞、大细胞性神经分泌细胞、肠和呼吸道细胞、甲状腺细胞、甲状旁腺细胞、肾上腺细胞、分泌睾丸激素的睾丸莱迪格细胞、分泌雌激素的卵泡内膜细胞、分泌孕酮的破裂卵泡的黄体细胞、近肾小球细胞、肾脏致密斑细胞、肾脏极周细胞、肾脏的肾小球系膜细胞、胰岛细胞;角质化上皮细胞包括但不限于:表皮角质化细胞、表皮基底细胞、指甲和脚趾甲的角质化细胞、甲床基底细胞、延髓毛干细胞、皮质毛干细胞、表皮毛干细胞、表皮毛根鞘细胞、赫胥黎氏层的毛根鞘细胞、亨勒层的毛根鞘细胞、外毛根鞘细胞、以及毛基质细胞;湿分层化屏障上皮细胞包括但不限于:角膜、舌、口腔、食道、肛管、远端尿道和阴道的层状鳞状上皮的表面上皮细胞和上皮的基底细胞、以及尿路上皮细胞;感觉转导细胞包括但不限于:柯蒂氏器官的听觉内毛细胞、柯蒂氏器官的听觉外毛细胞、嗅觉上皮基底细胞、冷敏感初级感觉神经元、热敏感初级感觉神经元、表皮细胞的默克尔细胞、嗅觉感受神经元、疼痛敏感初级感觉神经元、眼部视网膜感光细胞、本体感受初级感觉神经元、触敏初级感觉神经元、I型颈动脉体细胞、II型颈动脉体细胞、耳前庭系统的I型毛细胞、耳前庭系统的II型毛细胞和I型味蕾细胞;自主神经元细胞包括但不限于:胆碱能神经细胞、肾上腺素能神经细胞、以及肽能神经细胞;感觉器官和外周神经元支持细胞包括但不限于:柯蒂氏器官(螺旋器)的内柱细胞、柯蒂氏器官的外柱细胞、柯蒂氏器官的内指状细胞、柯蒂氏器官的外指状细胞、柯蒂氏器官的边缘细胞、柯蒂氏器官的汉森细胞、前庭器官支持细胞、味蕾支持细胞、嗅上皮支持细胞、雪旺细胞、卫星神经胶质细胞、以及肠神经胶质细胞;中枢神经系统神经元和神经胶质细胞包括但不限于:星形细胞、神经元细胞、少突胶质细胞、以及纺锤体神经元;晶状体细胞包括但不限于:前晶状体上皮细胞以及含晶状体蛋白的晶状体纤维细胞;代谢和储存细胞包括但不限于:脂肪细胞和肝脏脂肪细胞;屏障功能细胞包括但不限于:肾壁细胞、肾小球足细胞、肾近端小管刷状缘细胞、亨利氏套细段细胞、肾远端小管细胞、肾集合管细胞、主细胞、闰细胞、I型肺细胞、胰管细胞、非纹状管细胞、主细胞、闰细胞、导管细胞、肠刷状缘细胞、外分泌腺纹状管细胞、胆囊上皮细胞、输出小管无纤毛细胞、附睾主细胞、以及附睾基底细胞;细胞外基质细胞包括但不限于:成釉细胞上皮细胞(Ameloblast epithelial cell)、耳前庭系统的半月面上皮细胞、柯蒂氏器官齿间上皮细胞、松散结缔组织成纤维细胞、角膜成纤维细胞、肌腱成纤维细胞、骨髓网状组织成纤维细胞、其他非上皮成纤维细胞、外膜细胞,椎间盘髓核细胞、成牙骨质细胞/牙骨质细胞、成牙质细胞/牙本质细胞(odontocyte),透明软骨细胞、纤维软骨细胞、弹性软骨细胞、成骨细胞/骨细胞、骨原细胞、眼球玻璃体的玻璃体细胞、耳外淋巴隙星状细胞、肝星状细胞、以及胰星状细胞;收缩细胞包括但不限于:骨骼肌细胞、卫星细胞、心肌细胞、平滑肌细胞、虹膜的肌上皮细胞、以及外分泌腺肌上皮细胞;血液和免疫系统细胞包括但不限于:红细胞、巨核细胞、单核细胞、结缔组织巨噬细胞、表皮朗格汉斯细胞、破骨细胞、树突状细胞、小神经胶质细胞、中性粒细胞、嗜酸性粒细胞、嗜碱性粒细胞、杂交瘤细胞、肥大细胞、辅助T细胞、抑制T细胞、细胞毒T细胞、自然杀伤T细胞、B细胞、自然杀伤细胞、网状细胞、血液和免疫系统的干细胞和定向祖细胞;生殖细胞包括但不限于:卵原细胞/卵母细胞、精细胞、精母细胞、精原细胞、以及精子;滋养细胞包括但不限于:卵巢卵泡细胞、以及睾丸支持细胞、胸腺上皮细胞;间质细胞包括但不限于:间质肾细胞以及前述细胞的任何组合。
其他已知生物制剂的非限制性示例包括但不限于:阿布辛格斯(Abbosynagis)、阿贝格(Abegrin)、安挺乐(Actemra)、AFP-Cide、安托瓦(Antova)、亚舍拉(Arzerra)、奥瑞西斯(Aurexis)、阿瓦斯丁(Avastin)、本利斯塔(Benlysta)、百克沙(Bexxar)、布隆特斯(Blontress)、博萨特亚(Bosatria)、坎帕斯(Campath)、CEA-Cide、CEA-Scan、希敏佳(Cimzia)、斯朗达(Cyramza)、依可拓拔(Ektomab)、爱必妥(Erbitux)、福比例新特(FibriScint)、格子佤(Gazyva)、赫塞汀(Herceptin)、hPAM4-Cide、HumaSPECT、HuMax-CD4、HuMax-EGFr、修美乐(Humira)、HuZAF、海步瑞西科(Hybri-ceaker)、Ilaris、因迪马斯(Indimacis)-125、卡达西拉(Kadcyla)、勒门特达(Lemtrada)、勒可阿瑞斯(LeukArrest)、勒克斯阚(LeukoScan)、雷珠单抗(Lucentis)、林福木恩(Lymphomun)、林福斯堪(LymphoScan)、林福斯特(LymphoStat)-B、迈巴斯拉(MabThera)、米克葛巴(Mycograb)、麦罗塔(Mylotarg)、密斯金(Myoscint)、纽特斯派克(NeutroSpec)、纽曼士接(Numax)、诺维恩(Nuvion)、奥密塔克(Omnitarg)、欧珀地蔚(Opdivo)、欧斯科隆(Orthoclone)OKT3、欧瓦瑞克(OvaRex)、潘诺瑞克(Panorex)、罗利亚(Prolia)、帕洛斯塔斯科(Prostascint)、瑞体肤、瑞米凯德(Remicade)、瑞默瓦波(Removab)、仁卡勒斯(Rencarex)、芮泊罗(ReoPro)、锐宿母(Rexomun)、瑞图宣(Rituxan)、若安挺乐(RoActemra)、斯克提木(Scintimun)、欣普尼(Simponi)、丝穆勒科特(Simulect)、索利斯(Soliris)、喜达诺(Stelara)、辛格斯(Synagis)、塔科特斯(Tactress)、瑟拉克米(Theracim)、瑟拉金(Theragyn)、撕拉洛克(Theraloc)、提萨布里(Tysabri)、维克替比(Vectibix)、魏璐马(Verluma)、索雷尔(Xolair)、易唯一(Yervoy)、赛尼哌(Zenapax)、和泽娃灵(Zevalin)以及它们的组合。
已知的单克隆抗体的非限制性示例包括但不限于:3F8、8H9、阿巴莫单抗、阿昔单抗、阿比特珠单抗(Abituzumab)、阿布鲁单抗(Abrilumab)、阿克托单抗(Actoxumab)、阿达木单抗、阿德木单抗、阿德堪单抗(Aducanumab)、阿非西维单抗(Afasevikumab)、阿非莫单抗、阿夫土珠单抗、培阿珠单抗、ALD518、ALD403、阿仑珠单抗、阿利库单抗(Alirocumab)、阿妥莫单抗喷替酸盐、阿玛土西单抗(Amatuximab)、AMG 334、马安那莫单抗(Anatumomabmafenatox)、安妥单抗(Anetumab ravtansine)、安弗露单抗(Anifrolumab)、安鲁珠单抗、阿泊珠单抗、阿西莫单抗、阿斯万卡单抗(Ascrinvacumab)、阿塞珠单抗、阿特立珠单抗(Atezolizumab)、阿替奴单抗(Atinumab)、阿替珠单抗、阿托木单抗、阿维鲁单抗(Avelumab)、巴匹珠单抗、巴利昔单抗、巴维妥昔单抗(Bavituximab)、贝妥莫单抗(Bectumomab)、贝戈罗单抗(Begelomab)、贝利木单抗、苯那利珠单抗(Benralizumab)、柏替木单抗(Bertilimumab)、贝索单抗(Besilesomab)、贝伐单抗、贝兹托单抗(Bezlotoxumab)、比西单抗(Biciromab)、拜马单抗、拜莫克珠单抗(Bimekizumab)、比伐妥珠单抗(Bivatuzumab mertansine)、比勒斯单抗(Bleselumab)、博纳吐单抗、布隆土单抗、布罗锁珠单抗(Blosozumab)、博库斯珠单抗(Bococizumab)、布拉兹库单抗(Brazikumab)、布妥昔单抗、布拉吉单抗、布罗芦单抗、布罗鲁珠单抗(Brolucizumab)、波替妥珠单抗(Brontictuzumab)、布洛苏单抗(Burosumab)、卡比萊珠单抗(Cabiralizumab)、卡纳努单抗(Canakinumab)、莫坎妥珠单抗(Cantuzumabmertansine)、莫坎妥珠单抗罗夫坦辛(Cantuzumab ravtansine)、卡帕齐珠单抗(Caplacizumab)、卡波米单抗喷地肽(capromabpendetide)、卡路单抗(Carlumab)、卡罗图西单抗(Carotuximab)、卡妥索单抗、cBR96-多柔比星免疫偶联物、卡德丽珠单抗(Cedelizumab)、克果图珠单抗(Cergutuzumabamunaleukin)、赛妥珠单抗、西妥昔单抗、泊西他妥珠单抗(Citatuzumab bogatox)、西妥木单抗、克拉杂单抗(Clazakizumab)、克乐诺西单抗(Clenoliximab)、替坦司可利妥珠单抗、克锥特珠单抗(Codrituzumab)、克托西单抗(Coltuximab ravtansine)、可那木单抗(Conatumumab)、可丝珠单抗(Concizumab)、CR6261、克仁珠单抗(Crenezumab)、克洛特单抗(Crotedumab)、达西珠单抗、达利珠单抗、达鲁妥珠单抗(Dalotuzumab)、达皮罗珠单抗(Dapirolizumab pegol)、达托木单抗、德克特单抗(Dectrekumab)、德姆茨单抗(Demcizumab)、地宁图珠单抗(Denintuzumab mafodotin)、地诺单抗、地帕西珠单抗(Depatuxizumab mafodotin)、地罗西单抗(Derlotuximabartiox)、地莫单抗(Detumomab)、定妥昔单抗(Dinutuximab)、地达夫单抗(Diridavumab)、冬麻罗单抗(Domagrozumab)、阿托度单抗(Dorlimomab aritox)、多兹图单抗(Drozitumab)、度立凸单抗(Duligotumab)、度丕卢单抗(Dupilumab)、度夫芦单抗(Durvalumab)、度司荼单抗(Dusigitumab)、伊克麦昔单抗(Ecromeximab)、依库珠单抗、埃巴单抗(Edobacomab)、依决洛单抗、依法珠单抗、依芬古单抗、依德卢单抗(Eldelumab)、依格珠单抗(Elgemtumab)、依罗珠单抗(Elotuzumab)、依西莫单抗(Elsilimomab)、依麻特珠单抗(Emactuzumab)、依米特珠单抗(Emibetuzumab)、依米西珠单抗(Emicizumab)、恩凡珠单抗(Enavatuzumab)、恩夫图单抗(Enfortumab vedotin)、聚乙二醇化恩莫单抗(Enlimomab pegol)、恩波妥珠单抗(Enoblituzumab)、恩诺珠单抗(Enokizumab)、恩提库单抗(Enoticumab)、恩昔妥昔单抗(Ensituximab)、恩皮莫单抗(Epitumomab cituxetan)、依帕珠单抗、厄恩诺单抗(Erenumab)、厄利珠单抗(Erlizumab)、艾土马单抗(Ertumaxomab)、伊塔木单抗(Etaracizumab)、伊特利珠单抗(Etrolizumab)、依凡纳单抗(Evinacumab)、依罗库单抗(Evolocumab)、艾韦单抗(Exbivirumab)、法索单抗(Fanolesomab)、法拉莫单抗(Faralimomab)、伐尔妥珠单抗(Farletuzumab)、法斯单抗、FBTA05、泛维珠单抗(Felvizumab)、菲兹诺单抗(Fezakinumab)、菲巴珠单抗(Fibatuzumab)、菲拉特珠单抗(Ficlatuzumab)、弗吉妥姆单抗(Figitumumab)、弗瑞单抗(Firivumab)、弗兰单抗(Flanvotumab)、弗乐提单抗(Fletikumab)、冯特利珠单抗(Fontolizumab)、芙拉单抗(Foralumab)、夫瑞单抗(Foravirumab)、弗瑞索单抗(Fresolimumab)、弗兰单抗(Fulranumab)、富图希单抗(Futuximab)、加坎珠单抗(Galcanezumab)、加利昔单抗(Galiximab)、加尼单抗(Ganitumab)、甘腾纳单抗(Gantenerumab)、加维莫单抗(Gavilimomab)、吉妥珠单抗奥佐米星、格弗珠单抗(Gevokizumab)、吉瑞妥昔单抗(Girentuximab)、戈姆妥姆单抗(Glembatumumab vedotin)、戈利木单抗、戈米利单抗、固塞单抗(Guselkumab)、艾巴利珠单抗、替伊莫单抗(Ibritumomab tiuxetan)、伊库克单抗(Icrucumab)、伊达瑞珠单抗(Idarucizumab)、伊戈伏单抗(Igovomab)、IMA-638、IMAB362、尹马鲁单抗(Imalumab)、英西单抗(Imciromab)、尹戈妥珠单抗(Imgatuzumab)、尹卡单抗(Inclacumab)、尹达西单抗(Indatuximabravtansine)、英杜斯妥单抗(Indusatumab vedotin)、英彼利珠单抗(Inebilizumab)、英夫利昔单抗、伊诺莫单抗(inolimomab)、因诺珠单抗(Inotuzumab ozogamicin)、因特姆单抗(Intetumumab)、伊皮木单抗(Ipilimumab)、伊拉土木单抗(Iratumumab)、伊撒西单抗(Isatuximab)、伊利珠单抗(Itolizumab)、伊希珠单抗(Ixekizumab)、克里希单抗、拉贝珠单抗(Labetuzumab)、兰波单抗(Lambrolizumab)、兰波利珠单抗(Lampalizumab)、兰纳德单抗(Lanadelumab)、兰德珠单抗(Landogrozumab)、拉普特西单抗(Laprituximabemtansine)、LBR-101/PF0442g7429、罗氏单抗、来马索单抗(Lemalesomab)、棱德里珠单抗(Lendalizumab)、棱西单抗(Lenzilumab)、乐德木单抗(Lerdelimumab)、来沙木单抗、利韦单抗、利伐特珠单抗(Lifastuzumab vedotin)、利格里珠单抗(Ligelizumab)、立罗妥单抗(Lilotomab satetraxetan)、林妥珠单抗、利瑞单抗(Lirilumab)、罗德西珠单抗(Lodelcizumab)、洛克弗单抗(Lokivetmab)、罗瓦妥珠单抗(Lorvotuzumab mertansin)、鲁卡妥姆单抗(Lucatumumab)、鲁利珠单抗(Lulizumab pegol)、鲁昔单抗、鲁姆妥珠单抗(Lumretuzumab)、LY2951742、马帕木单抗、马格西单抗(Margetuximab)、马斯利莫单抗(Maslimomab)、马妥珠单抗、马维珠单抗、美泊利单抗、美替木单抗(Metelimumab)、米拉珠单抗(Milatuzumab)、敏特单抗(Minretumomab)、米弗西单抗(Mirvetuximabsoravtansine)、米妥莫单抗、莫加木珠单抗、莫纳利珠单抗(Monalizumab)、莫洛利单抗(Morolimumab)、莫维珠单抗、莫昔妥木单抗(Moxetumomab pasudotox)、莫罗单抗-CD3、纳考洛单抗(Nacolomab tafenatox)、纳米洛单抗(Namilumab)、纳布妥木单抗(Naptumomabestafenatox)、纳鲁西单抗(Naratuximab emtansine)、纳鲁特单抗(Narnatumab)、那他珠单抗、那西珠单抗(Navicixizumab)、纳弗单抗(Navivumab)、奈巴库单抗、奈昔单抗、奈莫利珠单抗(Nemolizumab)、奈瑞莫单抗(Nerelimomab)、奈弗库单抗(Nesvacumab)、尼妥珠单抗、尼莫单抗(Nivolumab)、诺非单抗(Nofetumomab merpentan)、奥比托西单抗(Obiltoxaximab)、阿托珠单抗、奥卡拉珠单抗、奥克利珠单抗(Ocrelizumab)、奥度莫单抗(Odulimomab)、奥法木单抗、欧妥单抗(Olaratumab)、欧罗单抗(Olokizumab)、奥马珠单抗、欧那妥珠单抗(Onartuzumab)、欧特西珠单抗(Ontuxizumab)、欧皮西单抗(Opicinumab)、莫奥珠单抗(Oportuzumab monatox)、奥戈伏单抗、奥特库单抗(Orticumab)、奥利昔珠单抗(Otelixizumab)、奥特托珠单抗(Otlertuzumab)、奥昔卢单抗(Oxelumab)、奥赞珠单抗(Ozanezumab)、欧拉丽珠单抗(Ozoralizumab)、帕吉昔单抗、帕利珠单抗、帕莫乐单抗(Pamrevlumab)、帕尼单抗、潘可单抗(Pankomab)、帕诺库单抗(Panobacumab)、帕萨妥珠单抗(Parsatuzumab)、帕考珠单抗、帕束妥昔珠单抗(Pasotuxizumab)、帕特利珠单抗(Pateclizumab)、帕特妥单抗(Patritumab)、派姆单抗(Pembrolizumab)、排姆妥姆单抗(Pemtumomab)、排乐珠单抗(Perakizumab)、帕妥珠单抗(Pertuzumab)、培克珠单抗、匹狄立珠单抗(Pidilizumab)、匹伐珠单抗(Pinatuzumab vedotin)、并妥木单抗(Pintumomab)、帕拉库单抗(Placulumab)、帕洛利珠单抗(Plozalizumab)、泊加丽珠单抗(Pogalizumab)、波拉妥珠单抗(Polatuzumab vedotin)、泊纳珠单抗(Ponezumab)、泊洛利珠单抗(Prezalizumab)、普立昔单抗(Priliximab)、普特夏西单抗(Pritoxaximab)、普林木单抗(Pritumumab)、PRO 140、秋丽珠单抗(Quilizumab)、雷克妥木单抗(Racotumomab)、雷德妥单抗(Radretumab)、瑞非单抗(Rafivirumab)、拉潘西珠单抗(Ralpancizumab)、雷莫芦单抗(Ramucirumab)、兰尼单抗、瑞西巴库单抗(raxibacumab)、瑞凡珠单抗(Refanezumab)、瑞加韦单抗(Regavirumab)、瑞利珠单抗(Reslizumab)、利妥木单抗、利诺库单抗(Rinucumab)、利散珠单抗(Risankizumab)、利妥昔单抗、利巴珠单抗(Rivabazumab pegol)、罗妥木单抗(Robatumumab)、洛乐杜单抗(Roledumab)、罗姆珠单抗(Romosozumab)、荣塔里珠单抗(Rontalizumab)、罗弗皮珠单抗(Rovalpituzumab tesirine)、罗维珠单抗(Rovelizumab)、卢利珠单抗(Ruplizumab)、沙斯妥珠单抗(Sacituzumab govitecan)、萨摩利珠单抗(Samalizumab)、萨皮利珠单抗(Sapelizumab)、萨里单抗(Sarilumab)、沙妥莫单抗喷地肽(satumomab pendetide)、苏金单抗、色瑞班妥单抗(Seribantumab)、色托西单抗(Setoxaximab)、司韦单抗(Sevirumab)、SGN-CD19A、SGN-CD33A、西罗珠单抗(Sibrotuzumab)、西法木单抗、希妥昔单抗(Siltuximab)、希特珠单抗(Simtuzumab)、西利珠单抗(Siplizumab)、希鲁库单抗(Sirukumab)、索非妥珠单抗(Sofituzumab vedotin)、苏兰珠单抗(Solanezumab)、索利特单抗(Solitomab)、森纳西珠单抗(Sonepcizumab)、森图珠单抗(Sontuzumab)、司他芦单抗(Stamulumab)、硫索单抗(Sulesomab)、苏珠单抗(Suvizumab)、它布鲁单抗(Tabalumab)、它卡斯珠单抗(Tacatuzumab tetraxetan)、塔道珠单抗(Tadocizumab)、他利珠单抗(Talizumab)、它木弗单抗(Tamtuvetmab)、它尼珠单抗(tanezumab)、泰普利莫单抗(Taplitumomab paptox)、它瑞妥单抗(Tarextumab)、太妃珠单抗(Tefibazumab)、阿替莫单抗(Telimomab aritox)、特纳妥姆单抗(Tenatumomab)、替奈昔单抗(Teneliximab)、替利珠单抗、特普妥姆单抗(Teprotumumab)、特西多单抗(Tesidolumab)、特托罗单抗(Tetulomab)、特则培单抗(Tezepelumab)、TGN1412、替西木单抗(Ticilimumab)、替卡妥珠(Tigatuzumab)、替卓珠单抗(Tildrakizumab)、替莫单抗(Timolumab)、替索托单抗(Tisotumab vedotin)、TNX-650、托珠单抗、托利珠单抗(Toralizumab)、托萨托单抗(Tosatoxumab)、托西莫单抗(Tositumomab)、托韦妥单抗(Tovetumab)、川隆单抗(tralokinumab)、曲妥珠单抗(Trastuzumab)、曲妥珠单抗埃姆他辛(Trastuzumab emtansine)、TRBS07、曲加利珠单抗(Tregalizumab)、曲美木单抗(Tremelimumab)、曲弗单抗(Trevogrumab)、西莫白介素单抗(Tucotuzumab celmoleukin)、妥韦单抗(Tuvirumab)、乌立妥昔单抗(Ublituximab)、乌克普鲁单抗(Ulocuplumab)、乌鲁单抗(Urelumab)、乌托珠单抗(Urtoxazumab)、优特金单抗(Ustekinumab)、乌托米单抗(Utomilumab)、维达西单抗(Vadastuximab talirine)、凡多珠单抗(Vandortuzumabvedotin)、凡提单抗(Vantictumab)、凡诺西珠单抗(Vanucizumab)、瓦帕西单抗(Vapaliximab)、瓦利芦单抗(Varlilumab)、瓦特里珠单抗(Vatelizumab)、维多珠单抗、维妥珠单抗、维帕莫单抗(Vepalimomab)、维森克单抗(Vesencumab)、维斯利珠单抗(Visilizumab)、弗巴利珠单抗(Vobarilizumab)、弗洛昔单抗(Volociximab)、沃斯妥珠单抗(Vorsetuzumab mafodotin)、伏妥莫单抗(Votumumab)、疝托珠单抗(Xentuzumab)、扎木单抗(Zanolimumab)、扎鲁木单抗(Zalutumumab)、扎木单抗、扎昔单抗(Zatuximab)、齐拉木单抗(Ziralimumab)和阿佐莫单抗(Zolimomab aritox)、和它们的组合。
为病毒性疾病研发的疫苗的示例包括但不限于:甲型肝炎疫苗、乙型肝炎疫苗、戊型肝炎疫苗、HPV疫苗、流感疫苗、流行性乙型脑炎疫苗、MMR疫苗、MMRV疫苗、脊髓灰质炎疫苗、狂犬病疫苗、轮状病毒疫苗、水痘疫苗、带状疱疹疫苗、天花疫苗、黄热病疫苗、腺病毒疫苗、乙型柯萨奇病毒疫苗、巨细胞病毒疫苗、人用登革热疫苗、人用东部马脑炎病毒疫苗、埃博拉疫苗、肠道病毒71疫苗、爱泼斯坦-巴尔疫苗、丙型肝炎疫苗、艾滋病疫苗、人用HTLV-1T淋巴细胞白血病疫苗、马尔堡病毒病疫苗、诺如病毒疫苗、人用呼吸道合胞病毒疫苗、严重急性呼吸道综合征(SARS)疫苗、人用西尼罗河病毒疫苗;细菌性疾病的示例包括但不限于:炭疽疫苗、DPT疫苗、Q热疫苗、Hib疫苗、结核病(BCG)疫苗、脑膜炎球菌疫苗、伤寒疫苗、肺炎链球菌结合疫苗、肺炎球菌多糖疫苗、霍乱疫苗、龋疫苗、埃立克体病疫苗、麻风疫苗、莱姆病疫苗、金黄色葡萄球菌疫苗、化脓性链球菌疫苗、梅毒疫苗、土拉菌病疫苗、鼠疫耶尔森氏菌疫苗;寄生虫病的示例包括但不限于:疟疾疫苗、血吸虫病疫苗、恰加丝病疫苗、钩虫疫苗、人用华支睾吸虫病河盲疫苗、锥虫病疫苗、内脏利什曼病疫苗;非感染性疾病的示例包括但不限于:阿尔茨海默病淀粉样蛋白疫苗、乳腺癌疫苗、卵巢癌疫苗、前列腺癌疫苗、溶瘤病毒药剂(Talimogene laherparepvec)(T-VEC);疫苗还包括但不限于以下商品名称:ACAM2000、ActHIB、阿德萨(Adacel)、阿福洛利(Afluria)、四价阿福洛利(AFLURIAQUADRIVALENT)、阿格里夫(Agriflu)、BCG疫苗、BEXSERO、百思拉霞(Biothrax)、卜思特(Boostrix)、希瑞适(Cervarix)、康福熙(Comvax)、达忒瑟(DAPTACEL)、德克发(DECAVAC)、英格里希(Engerix)-B、复立达(FLUAD)、福禄立适(Fluarix)、四价福禄立适(FluarixQuadrivalent)、弗露博洛克(Flublok)、弗露希腊(Flucelvax)、四价弗露希腊(FlucelvaxQuadrivalent)、弗露拉法(FluLaval)、弗露米斯特(FluMist)、四价弗露米斯特(FluMistQuadrivalent)、伏必灵(Fluvirin)、四价弗露倧(Fluzone Quadrivalent)、弗露倧(Fluzone)、高剂量弗露倧和皮肤内弗露倧(Fluzone High-Dose and FluzoneIntradermal)、加德西(Gardasil)、加德西9、贺福立适(Havrix)、贺新立适(Hiberix)、印法克斯(Imovax)、英芬立适(Infanrix)、IPOL、依稀罗(Ixiaro)、JE-Vax、KINRIX、美那克查(Menactra)、门西比克(MenHibrix)、美诺门(Menomune)-A/C/Y/W-135、门福鸥(Menveo)、M-M-R II、M-M-Vax、帕迪丽(Pediarix)、PedvaxHIB、蓬塔克(Pentacel)、纽莫法(Pneumovax)23、珀利弗科思(Poliovax)、沛儿(Prevnar)、沛儿13、普罗栝达(ProQuad)、阔达丝(Quadracel)、四价(Quadrivalent)、拉布维特(RabAvert)、瑞抗必发(Recombivax)HB、罗特律(ROTARIX)、罗塔特克(RotaTeq)、特尼微克(TENIVAC)、TICE BCG、特培达(Tripedia)、川膜倍(TRUMENBA)、Twinrix、TYPHIM Vi、VAQTA、瓦瑞法克(Varivax)、瓦克罗(Vaxchora)、维弗提(Vivotif)、YF-Vax、伏带疹(Zostavax)、以及它们的组合。
可注射药物的示例包括但不限于:阿巴弗(Ablavar)(钆磷维塞三钠(Gadofosveset Trisodium)注射剂)、阿巴瑞克储库剂(奥巴里德宝(Abarelix Depot))、肉毒素A型(Abo肉毒杆菌毒素(Abobotulinumtoxin A))注射剂(丽舒妥(Dysport))、ABT-263、ABT-869、ABX-EFG、阿西托品(Accretropin)(生长激素(Somatropin)注射剂)、Acetadote(乙酰胺半胱氨酸(Acetylcysteine)注射剂)、乙酰唑胺注射剂(AcetazolamideInjection)、乙酰半胱氨酸注射剂(Acetadote)、安挺乐(托珠单抗注射剂)、Acthrel(注射用三氟乙酸绵羊可的瑞林三氟醋酸盐(Corticorelin Ovine Triflutate))、奥克图门(Actummune)、阿替普酶(Activase)、注射用阿昔洛韦(Acyclovir)(佐韦瑞克斯(Zovirax)注射剂)、阿德萨(Adacel)、阿达木单抗、Adenoscan(腺苷注射剂)、腺苷注射剂(Adenoscan)、阿德那克里克(Adrenaclick)、AdreView(用于静脉注射使用的碘1123苄胍(lobenguane 1123)注射剂)、阿福洛利(Afluria)、Ak-Fluor(荧光素注射剂)、Aldurazyme(拉罗尼酶(Laronidase))、阿糖苷酶注射剂(Ceredase)、阿尔肯尔(Alkeran)注射剂(盐酸美法仑注射剂)、注射用别嘌醇钠(Aloprim)、Aloprim(注射用别嘌醇钠)、前列地尔(Alprostadil)、Alsuma(舒马普坦注射剂)、ALTU-238、氨基酸注射剂、美乐欣(Aminosyn)、阿匹朱(Apidra)、阿普斯特(Apremilast)、注射用前列地尔双室系统(Caverject Impulse,凯威捷脉动)、AMG 009、AMG 076、AMG 102、AMG 108、AMG 114、AMG 162、AMG 220、AMG 221、AMG 222、AMG 223、AMG 317、AMG 379、AMG 386、AMG 403、AMG 477、AMG 479、AMG 517、AMG531、AMG 557、AMG 623、AMG 655、AMG 706、AMG 714、AMG 745、AMG 785、AMG 811、AMG 827、AMG 837、AMG 853、AMG 951、胺碘酮盐酸注射剂(盐酸胺碘酮注射剂,Amiodarone HClInjection)、异戊巴比妥钠注射剂(阿米妥钠)、阿米妥钠(异戊巴比妥钠注射剂)、阿那白滞素(Anakinra)、Aβ抗体(Anti-Abeta)、β7抗体(Anti-Beta7)、β20抗体(Anti-Beta20)、CD4抗体(Anti-CD4)、CD20抗体(Anti-CD20)、CD40抗体(Anti-CD40)、IFNα抗体(Anti-IFNalpha)、IL13抗体(Anti-IL13)、OX40L抗体(Anti-OX40L)、oxLDS抗体(Anti-oxLDS)、NGF抗体(Anti-NGF)、NRP1抗体(Anti-NRP1)、Arixtra(戊聚糖钠)、Amphadase(透明质酸酶注射剂)、Ammonul(苯乙酸钠和苯甲酸钠注射剂)、阿诺普克斯(Anaprox)、Anzemet注射剂(甲磺酸多拉司琼注射剂)、阿匹朱(赖谷胰岛素[rDNA来源]注射剂)、Apomab、Aranesp(阿法达贝泊汀)、Argatroban(阿加曲班注射剂)、盐酸精氨酸注射剂(R-Gene 10、曲安西龙(Aristocort)、己曲安奈德(Aristospan)、三氧化二砷注射剂(Trisenox)、盐酸阿替卡因(Articane HCl)和肾上腺素注射剂(Septocaine)、Arzerra(奥法木单抗注射剂)、Asclera(聚多卡醇注射剂)、阿特伦(Ataluren)、阿特伦-DMD、阿替洛尔(Atenolol)注射剂(天诺敏I.V.注射剂(Tenormin I.V.Injection))、苯磺酸阿曲库铵注射剂(阿曲库铵苯磺酸盐注射剂)、阿瓦斯丁(Avastin)、埃扎可坦(Azactam)注射剂(噻肟单胺菌素(Aztreonam)注射剂)、阿奇霉素(希舒美注射剂)、噻肟单胺菌素注射剂(埃扎可坦注射剂)、巴氯芬注射剂(力奥来素鞘内注射剂(LIORESAL INTRATHECAL))、抑菌水(Bacteriostatic Water)(注射用抑菌水)、巴氯芬注射剂(力奥来素鞘内注射剂)、油安瓶中的巴尔(Bal in Oil Ampules)(二巯基丙醇(Dimercarprol)注射剂)、百禾B(BayHepB)、百特(BayTet)、本纳注(Benadryl)、盐酸苯达莫司汀注射剂(Treanda)、甲磺酸苯扎托品注射剂(Cogentin)、倍他米松可注射悬浮液(倍他米松磷酸酯钠(Celestone Soluspan))、Bexxar、比西林(Bicillin)C-R 900/300(盘尼西林G苄星青霉素和盘尼西林G普鲁卡因注射剂)、博莱霉素(Blenoxane)(硫酸博莱霉素注射剂)、硫酸博来霉素注射剂(Blenoxane)、Boniva注射剂(伊班膦酸钠(IbandronateSodium)注射剂)、Botox Cosmetic(注射用Ona肉毒杆菌素(OnabotulinumtoxinA))、BR3-FC、Bravelle(尿促卵泡素注射剂)、Bretylium(溴苄铵注射剂)、甲己炔巴比妥钠(BrevitalSodium)(注射用美索比妥钠)、贝利新(Brethine)、贝利百西(Briobacept)、BTT-1023、盐酸布比卡因、Byetta、Ca-DTPA(喷替酸钙钠注射剂)、卡巴他赛注射剂(Jevtana)、咖啡因生物碱(Caffeine Alkaloid)(咖啡因和苯甲酸钠注射剂)、骨化三醇注射剂(罗钙全(Calcitrol))、罗钙全(骨化三醇注射剂)、氯化钙(氯化钙注射剂10%)、乙二胺四乙酸二钠钙(依地酸钙钠注射剂)、Campath(阿仑单抗(Altemtuzumab))、Camptosar注射剂(盐酸伊立替康)、卡纳努单抗注射剂(Ilaris)、硫酸卷曲霉素(Capastat Sulfate)(注射用卷曲霉素(Capreomycin))、注射用卷曲霉素(硫酸卷曲霉素)、Cardiolite(注射用锝Tc99司他比准备试剂盒(Prep kit for Technetium Tc99Sestamibi))、Carticel、Cathflo、注射用头孢唑啉和右旋糖(头孢唑啉(Cefazolin)注射剂)、盐酸头孢吡肟、头孢噻肟钠、头孢三嗪(Ceftriaxone)、思而赞(Cerezyme)、卡尼特(Carnitor)注射剂、凯威捷(Caverject)、倍他米松磷酸酯钠、赛里西欧(Celsior)、Cerebyx(磷苯妥英钠(Fosphenytoin Sodium)注射剂)、Ceredase(阿糖苷酶注射剂)、Ceretec(锝Tc99m依沙美肟(Exametazime)注射剂)、赛妥珠单抗、CF-101、氯霉素琥珀酸钠(琥珀酸钠氯霉素注射剂)、琥珀酸钠氯霉素注射剂(氯霉素琥珀酸钠)、考来胶(Cholestagel)(盐酸考来维仑)、绒毛膜促性腺激素(Choriogonadotropin)α注射剂(Ovidrel)、Cimzia、Cisplatin(顺氯氨铂注射剂)、Clolar(氯法拉滨注射剂)、克罗米酚柠檬酸盐(Clomiphine Citrate)、可乐定注射剂(Duraclon)、Cogentin(甲磺酸苄托品注射剂)、粘菌素(Colistimethate)注射剂(Coly-Mycin M)、Coly-Mycin M(粘菌素注射剂)、康帕斯(Compath)、盐酸考尼伐坦注射剂(Vaprisol)、注射用结合雌激素(妊马雌酮(Premarin)注射剂)、克帕松(Copaxone)、注射用三氟乙酸绵羊可的瑞林(Acthrel)、Corvert(富马酸伊布利特(Ibutilide Fumarate)注射剂)、库比星(Cubicin)(达托霉素注射剂)、CF-101、Cyanokit(注射用羟钴胺素)、阿糖胞苷脂质体(CytarabineLiposome)注射剂(DepoCyt)、氰钻胺、Cytovene(丙氧鸟苷)、D.H.E.45、达西珠单抗、Dacogen(地西他滨注射剂)、达替肝素(Dalteparin)、丹曲林IV(注射用丹曲林钠)、注射用丹曲林钠(丹曲林IV)、达托霉素注射剂(库比星(Cubicin))、达尔贝激素(Darbepoietin)α、DDAVP注射剂(乙酸去氨加压素注射剂)、Decavax、地西他滨注射剂(Dacogen)、无水乙醇(无水乙醇注射剂)、德尼单抗注射剂(Prolia)、Delatestryl、Delestrogen、达特肝素钠(Delteparin Sodium)、的帕肯(Depacon)(丙戊酸钠注射剂)、德普梅德尔(醋酸甲泼尼龙可注射悬浮液)、DepoCyt(阿糖胞苷脂质体注射剂)、DepoDur(硫酸吗啡XR脂质体(MorphineSulfate XR Liposome)注射剂)、乙酸去氨加压素注射剂(DDAVP注射剂)、德普(Depo)-雌二醇、德普-普维拉(Provera)104mg/ml、德普-普维拉150mg/ml、德普-睾酮、注射用敌拉造可散、仅静脉输注(Totect)、右旋糖/电解质、右旋糖和氯化钠注射剂(0.9%氯化钠中的右旋糖5%)、右旋糖、地西泮注射剂(Diazepam Injection)、地高辛注射剂(拉诺辛注射剂)、双氢吗啡(Dilaudid)-HP(盐酸二氢吗啡酮注射剂)、二巯基丙醇注射剂(油安瓶中的巴尔)、苯海拉明注射剂(苯那君(Benadryl)注射剂)、双嘧达莫注射剂(潘生丁注射剂)、DMOAD、注射用多西他赛(Taxotere)、甲磺酸多拉司琼注射剂(Anzemet注射剂)、Doribax(注射用多利培南)、注射用多利培南(Doribax)、度骨化醇(Doxercalciferol)注射剂(Hectorol注射剂)、Doxil(盐酸阿霉素脂质体(Doxorubicin Hcl Liposome)注射剂)、盐酸阿霉素脂质体注射剂(Doxil)、Duraclon(可乐亭注射剂)、硫酸吗啡(Duramorph)(吗啡注射剂)、Dysport(Abo肉毒杆菌毒素A型注射剂)、艾卡拉肽注射剂(Kalbitor)、EC-萘普生(甲氧萘丙酸(naproxen))、乙二胺四乙酸钙二钠注射剂(依地酸二钠钙)、Edex(注射用前列地)、英格里希(Engerix)、滕喜龙注射剂(依酚氯铵(Enlon))、酒石酸伊利果斯(Eliglustat Tartate)、乐沙定(奥沙利铂注射剂)、易梦德(Emend)注射剂(福沙吡坦二甲葡胺(FosaprepitantDimeglumine)注射剂)、依那普利注射剂(埃那拉普利尔制剂(Enalaprilat)注射剂)、依酚氯铵(滕喜龙(Edrophonium)注射剂)、依诺肝素钠(Enoxaparin Sodium)注射剂(Lovenox)、Eovist(钆塞酸二钠(Gadoxetate Disodium)注射剂)、Enbrel(依那西普(etanercept))、依诺肝素(Enoxaparin)、依皮瑟(Epicel)、肾上腺素(Epinepherine)、肾上腺素笔(Epipen)、初级肾上腺素笔(Epipen Jr.)、依帕珠单抗、爱必妥(Erbitux)、厄他培南(Ertapenem)注射剂(怡万之(Invanz))、红细胞生成素(Erythropoieten)、必需氨基酸注射剂(Nephramine)、环戊丙酸雌二醇(Estradiol Cypionate)、戊酸雌二醇(Estradiol Valerate)、依那西普、艾塞那肽注射剂(百泌达(Byetta))、艾佛特(Evlotra)、半乳糖苷酶(Fabrazyme)(阿达西达瑟(Adalsidase)β)、法莫替丁注射剂、FDG(氟代脱氧葡萄糖F18注射剂)、芙拉和莫(Feraheme)(纳米氧化铁(Ferumoxytol)注射剂)、菲立磁四代(Feridex I.V.)(氧化铁纳米微粒(Ferumoxides)可注射溶液)、费提娜(Fertinex)、氧化铁纳米微粒可注射溶液(菲立磁四代)、纳米氧化铁注射剂(芙拉和莫)、甲硝唑(Flagyl)注射剂(灭滴灵(Metronidazole)注射剂)、福禄立适(Fluarix)、氟拉达拉(Fludara)(磷酸氟达拉滨)、氟脱氧葡萄糖F18注射剂(FDG)、荧光素注射剂(Ak-Fluor)、弗丽丝汀AQ筒(Follistim AQ Cartridge)(促卵泡素β注射剂)、促卵泡素α注射剂(Gonal-f RFF)、促卵泡素β注射剂(弗丽丝汀AQ筒)、弗洛婷(Folotyn)(静脉注射用普拉曲沙溶液)、磺达肝癸钠(Fondaparinux)、Forteo(特立帕肽(rDNA来源)注射剂)、弗丝麻亭(Fostamatinib)、福沙吡坦二甲葡胺(FosaprepitantDimeglumine)注射剂(Emend注射剂)、膦甲酸钠注射剂(Foscavir)、Foscavir(膦甲酸钠注射剂)、磷苯妥英钠注射剂(Cerebyx)、磷丙泊酚钠注射剂(Lusedra)、法安明(Fragmin)、Fuzeon(恩夫韦肽(enfuvirtide))、GA101、钆贝葡胺注射剂(Multihance)、钆磷维塞三钠注射剂(Ablavar)、钆特醇(Gadoteridol)注射溶液(ProHance)、钆弗塞胺(Gadoversetamide)注射剂(OptiMARK)、伽岛二钠(Gadoxetate Disodium)注射剂(Eovist)、加尼瑞克(Ganirelix)(醋酸加尼瑞克注射剂)、加德西(Gardasil)、GC1008、GDFD、注射用吉妥珠单抗奥唑米星(Gemtuzumab Ozogamicin)(Mylotarg)、基因重组人生长激素(Genotropin)、庆大霉素注射剂、GENZ-112638、戈利木单抗注射剂(欣普尼(Simponi)注射剂)、Gonal-f RFF(促卵泡素α注射剂)、盐酸格拉司琼(康泉(Kytril)注射剂)、硫酸庆大霉素、醋酸格拉替雷、胰高血糖素(Glucagen)、胰高血糖素、HAE1、Haldol(氟哌啶醇注射剂)、贺福立适(Havrix)、Hectorol注射剂(度骨化醇(Doxercalciferol)注射剂)、何德浩途径抑制剂(HedgehogPathway Inhibitor)、肝素、赫赛汀、hG-CSF、优泌乐(Humalog)、人类生长激素、优猛茁(Humatrope)、喜码士(HuMax)、喜美康(Humegon)、修美乐(Humira)、优泌林(Humulin)、伊班膦酸钠注射剂(Boniva注射剂)、布洛芬赖氨酸盐注射剂(NeoProfen)、富马酸伊布利特注射剂(Corvert)、伊达米星(Idamycin)PFS(盐酸伊达比星(Idarubicin Hydrochloride)注射剂)、盐酸伊达比星注射剂(伊达米星PFS)、Ilaris(卡纳努单抗注射剂)、注射用亚胺培南和西司他丁(Primaxin I.V.)、依米彻(Imitrex)、注射用inco肉毒杆菌毒素(Incobotulinumtoxin)A型(Xeomin)、Increlex(美卡舍明(Mecasermin)[rDNA来源]注射剂)、消炎痛(Indocin)IV(吲哚美辛注射剂)、吲哚美辛注射剂(消炎痛IV)、英芬立适(Infanrix)、亭扎肝素(Innohep)、胰岛素、门冬胰岛素[rDNA来源]注射剂(NovoLog)、甘精胰岛素[rDNA来源]注射剂(Lantus)、赖谷胰岛素[rDNA来源]注射剂(阿匹朱)、注射用干扰素α-2b重组体(Intron A)、Intron A(注射用干扰素α-2b重组体)、Invanz(厄他培南注射剂)、善思达(Invega Sustenna)(棕榈酸帕利哌酮缓释剂(Paliperidone PalmitateExtended-Release)可注射悬浮液)、Invirase(甲磺酸沙奎那韦)、静脉输注用途的碘苄胍1123注射剂(AdreView)、碘普罗胺注射剂(优维显(Ultravist))、碘佛醇注射剂(安射力(Optiray)注射剂)、Iplex(美卡舍明林菲培[rDNA来源]注射剂)、依皮法克(Iprivask)、盐酸伊立替康(Camptosar注射剂)、蔗糖铁注射剂(Venofer)、Istodax(注射用罗米地辛)、依曲康唑注射剂(斯皮仁诺注射剂)、Jevtana(卡巴他赛注射剂)、九纳西(Jonexa)、Kalbitor(艾卡拉肽注射剂)、D5NS中的KCL(在5%右旋糖和氯化钠中的氯化钾注射剂)、D5W中的KCL、NS中的KCL、口内膏(Kenalog)10注射剂(醋酸曲安奈德(Triamcinolone Acetonide)可注射悬浮液)、Kepivance(帕利夫明)、开浦兰注射剂(左乙拉西坦)、角化细胞(Keratinocyte)、KFG、激酶抑制剂、Kineret(阿那白滞素)、Kinlytic(尿激酶注射剂)、金利(Kinrix)、克诺平(氯硝安定)、Kytril注射剂(盐酸格拉司琼)、拉科酰胺片和注射剂(Vimpat)、乳酸林格氏液(Lactated Ringer's)、拉诺辛注射剂(地高辛注射剂)、注射用兰索拉唑(普托平I.V.)、兰德仕(Lantus)、亚叶酸钙(甲酰四氢叶酸钙注射剂)、朗泰(Lente)(L)、莱普亭(Leptin)、诺和平(Levemir)、乐凯沙格司亭(Leukine Sargramostim)、醋酸亮丙瑞林、左甲状腺素、左乙拉西坦(开浦兰注射剂)、依诺肝素(Lovenox)、左卡尼汀注射剂(卡尼丁注射剂)、乐西阚(Lexiscan)(瑞加德松(Regadenoson)注射剂)、力奥来素鞘内注射液(巴氯芬注射剂)、利拉鲁肽[rDNA]注射剂(诺和力)、Lovenox(依诺肝素钠注射剂)、Lucentis(兰尼单抗注射剂)、卢米兹莫(Lumizyme)、Lupron(醋酸亮丙瑞林注射剂)、Lusedra(磷丙泊酚钠注射剂)、马奇(Maci)、硫酸镁(硫酸镁注射剂)、甘露醇注射剂(甘露醇IV)、麻卡因(盐酸布比卡因和肾上腺素注射剂)、马斯平(Maxipime)(注射用盐酸头孢吡肟)、锝注射剂的MDP多剂量试剂盒(锝Tc99m依沙美肟注射剂)、美卡舍明[rDNA来源]注射剂(Increlex)、美卡舍明林菲培[rDNA来源]注射剂(Iplex)、盐酸美法仑注射剂(爱克兰(Alkeran)注射剂)、氨甲蝶呤、美那克查(Menactra)、美诺孕(Menopur)(促生育素注射剂)、注射用促生育素(Repronex)、注射用美索比妥钠(甲己炔巴比妥钠(Brevital Sodium))、盐酸甲基多巴乙酯注射剂溶液(盐酸甲基多巴乙酯)、亚甲蓝(亚甲蓝注射剂)、醋酸甲泼尼龙可注射悬浮液(德普梅德尔(DepoMedrol))、梅特麦(MetMab)、甲氧氯普胺注射剂(灭吐灵(Reglan)注射剂)、麦处定(注射用尿促卵泡素)、甲硝哒唑注射剂(灭滴灵(Flagyl)注射剂)、密钙息、咪达唑仑(咪达唑仑注射剂)、米帕拉(Mimpara)(西那卡塞(Cinacalet))、米诺环素注射剂(二甲胺四环素注射剂)、二甲胺四环素注射剂(米诺环素注射剂)、米泊美生(Mipomersen)、注射用米托蒽醌浓缩剂(诺凡特龙)、吗啡注射剂(硫酸吗啡)、硫酸吗啡XR脂质体注射剂(DepoDur)、鱼肝油酸钠(鱼肝油酸钠注射剂)、莫特塞尼(Motesanib)、普乐沙福(Mozobil)(注射用皮乐霞(Plerixa))、Multihance(钆贝葡胺注射剂)、多种电解质和右旋糖注射剂、多种电解质注射剂、Mylotarg(注射用吉妥珠单抗奥唑米星)、Myozyme(α-阿葡糖苷酶(Alglucosidase alfa))、萘夫西林注射剂(萘夫西林钠)、萘夫西林钠(萘夫西林注射剂)、纳曲酮XR注射剂(Vivitrol)、萘普生(甲氧萘丙酸)、NeoProfen(布洛芬赖氨酸盐注射剂)、癸酸诺龙(Nandrol Decanoate)、甲硫酸新斯的明(甲硫酸新斯的明注射剂)、NEO-GAA、NeoTect(锝Tc 99m地普奥肽注射剂)、Nephramine(必需氨基酸注射剂)、Neulasta(培非格司亭)、优保津(Neupogen)(非格司亭)、诺和灵、诺和锐、倍他依泊汀(NeoRecormon)、Neutrexin(三甲曲沙葡糖醛酸脂注射剂)、NPH(N)、Nexterone(盐酸胺碘酮注射剂)、Norditropin(生长激素(Somatropin)注射剂)、生理盐水(氯化钠注射剂)、诺凡特龙(注射用米托蒽醌浓缩剂)、诺和灵70/30一诺莱特(Innolet)(70%NPH,中性低精蛋白锌人胰岛素悬液和30%Regular,人胰岛素注射剂)、诺和锐(门冬胰岛素[rDNA来源]注射剂)、Nplate(罗米司亭)、诺折平(Nutropin)(注射用生长激素(rDNA来源))、诺折平AQ、Nutropin Depot(注射用生长激素(rDNA来源))、醋酸奥曲肽注射剂(善得定LAR)、奥克利珠单抗、奥法木单抗注射剂(Arzerra)、奥氮平缓释剂可注射悬浮液(Zyprexa Relprevv)、奥密塔克、Omnitrope(生长激素[rDNA来源]注射剂)、盐酸昂丹司琼注射剂(枢复宁注射剂)、OptiMARK(钆弗塞胺注射剂)、安射力注射剂(碘佛醇注射剂)、奥瑞希纳(Orencia)、阿维娃中的欧斯米特(Osmitrol)注射剂(阿维娃(Aviva)塑料容器250中的甘露醇注射剂)、维弗乐中的欧斯米特注射剂(维弗乐(Viaflex)塑料容器250中的甘露醇注射剂)、骨保护素(Osteoprotegrin)、Ovidrel(绒毛膜促性腺激素α注射剂)、苯唑西林(注射用苯唑西林)、奥沙利铂注射剂(乐沙定)、催产素注射剂(吡哆素)、棕榈酸帕利哌酮缓释剂可注射悬浮液(善思达)、帕米膦酸二钠注射剂(帕米磷酸钠注射剂)、静脉输注用帕尼单抗注射剂(Vectibix)、盐酸罂粟碱注射剂(罂素碱注射剂)、罂素碱注射剂(盐酸罂粟碱注射剂)、甲状旁腺素、帕立骨化醇注射剂触发瓶(Fliptop Vial)(Zemplar注射剂)、PARP抑制剂、帕迪丽(Pediarix)、PEGlntron、派罗欣(Peginterferon)、培非格司亭、苄星青霉素G和普鲁卡因青霉素G、Pentetate喷替酸钙钠注射剂(Ca-DTPA)、喷替酸锌钠注射剂(Zn-DTPA)、Pepcid注射剂(法莫替丁注射剂)、普格纳(Pergonal)、帕妥珠单抗、甲磺酰酚妥拉明(注射用甲磺酰酚妥拉明)、水杨酸毒扁豆碱(水杨酸毒扁豆碱(注射剂))、水杨酸毒扁豆碱(注射剂)(水杨酸毒扁豆碱)、哌拉西林和他唑巴坦注射剂(Zosyn)、吡哆素(催产素注射剂)、勃脉力(Plasma-Lyte)148(多种电解质注射剂)、勃脉力56和右旋糖(维弗乐塑料容器250中的多种电解质和右旋糖注射剂)、勃脉力(PlasmaLyte)、注射用皮乐霞(Plerixa)(普乐沙福,Mozobil)、聚多卡醇注射剂(Asclera)、氯化钾、静脉注射用普拉曲沙溶液(Folotyn)、醋酸普兰林肽注射剂(塞米琳(Symlin))、普雷马林注射剂(注射用共轭雌激素)、注射用锝Tc-99司他比准备试剂盒(Cardiolite)、普托平I.V.(注射用兰索拉唑)、Primaxin I.V.(注射用亚胺培南和西司他丁)、前干细胞素(Prochymal)、普罗克瑞(Procrit)、黄体酮、ProHance(钆特醇注射溶液)、Prolia(德尼单抗注射剂)、盐酸普鲁米近注射剂(盐酸异丙嗪注射剂)、盐酸普萘洛尔注射剂(Propranolol Hydrochloride Injection)、葡萄糖酸奎尼丁注射剂(奎尼丁注射剂)、奎尼丁注射剂(葡萄糖酸奎尼丁注射剂)、R-Gene 10(盐酸精氨酸注射剂)、兰尼单抗注射剂(Lucentis)、盐酸雷尼替丁注射剂(Zantac注射剂)、瑞体肤(Raptiva)、Reclast(唑来膦酸注射剂)、瑞抗比力克(Recombivarix)HB、瑞加德松注射剂(乐西阚)、灭吐灵注射剂(甲氧氯普胺注射剂)、瑞米凯德、磷能解(Renagel)、Renvela(碳酸司维拉姆)、Repronex(注射用促生育素)、立妥威(Retrovir)IV(齐多夫定注射剂)、rhApo2L/TRAIL、林格氏(Ringer’s)和5%右旋糖注射剂(右旋糖中的林格(Ringer))、林格氏注射剂(林格注射剂)、瑞图宣(Rituxan)、利妥昔单抗、罗氏芬(头孢三嗪)、罗库溴铵注射剂(Zemuron)、罗扰素-A(干扰素α-2a)、Romazicon(氟马西尼)、注射用罗米地辛(Istodax)、思增(Saizen)(生长激素注射剂)、善得定LAR(醋酸奥曲肽注射剂)、硬骨素(Sclerostin)Ab、Sensipar(西那卡塞)、Sensorcaine(盐酸布比卡因注射剂)、Septocaine(盐酸阿替卡因和肾上腺素注射剂)、Serostim LQ(生长激素(rDNA来源)注射剂)、Simponi注射剂(戈利木单抗注射剂)、醋酸钠(醋酸钠注射剂)、碳酸氢钠(碳酸氢钠5%注射剂)、乳酸钠(AVIVA中的乳酸钠注射剂)、苯乙酸钠和苯甲酸钠注射剂(Ammonul)、注射用生长激素(rDNA来源)(Nutropin)、斯皮仁诺注射剂(依曲康唑注射剂)、喜达诺(Stelara)注射剂(优特金单抗)、司坦琴(Stemgen)、舒芬太尼(枸橼酸舒芬太尼(Sufentanil Citrate)注射剂)、枸橼酸舒芬太尼注射剂(舒芬太尼(Sufenta))、孙麻弗(Sumavel)、舒马曲坦注射剂(Alsuma)、塞米琳、塞米琳笔、系统性何德浩拮抗剂(Systemic Hedgehog Antagonist)、Synvisc-One(希兰G-F20单次关节内注射剂)、埃罗替尼(Tarceva)、泰索帝(注射用多西他赛)、锝Tc 99m、注射用特拉万星(Vibativ)、替西罗莫司(Temsirolimus)注射剂(Torisel)、天诺敏I.V.注射剂(阿替洛尔注射剂)、特立帕肽(rDNA来源)注射剂(Forteo)、环戊丙酸睾酮、庚酸睾酮、丙酸睾酮、Tev-Tropin(生长激素,rDNA来源,注射用)、tgAAC94、氯化亚铊、茶碱、噻替派(噻替派注射剂)、即复宁(Thymoglobulin)(抗胸腺细胞球蛋白(兔))、适谪进(注射用促甲状腺激素α)、替卡西林钠和克拉维酸钾盖乐熙(Galaxy)(泰门汀注射剂)、帝根注射剂(可注射盐酸三甲氧苯酰胺)、泰门汀注射剂(替卡西林钠和克拉维酸钾盖乐熙)、替奈普酶(TNKase)、妥布霉素注射剂(托普霉素注射剂)、托珠单抗注射剂(安挺乐)、Torisel(替西罗莫司注射剂)、Totect(注射用右丙亚胺,仅静脉输注)、曲妥珠单抗-DM1、Travasol(氨基酸(注射剂))、Treanda(盐酸苯达莫司汀注射剂)、Trelstar(羟萘酸曲普瑞林可注射悬浮液(TriptorelinPamoate for Injectable Suspension))、醋酸曲安奈德、二醋酸去炎松、己曲安奈德可注射悬浮液(Aristospan注射剂20mg)、Triesence(醋酸曲安奈德可注射悬浮液)、可注射盐酸三甲氧苯酰胺(Tigan注射剂)、三甲曲沙葡萄糖醛酯注射剂(Neutrexin)、羟萘酸曲普瑞林可注射悬浮液(Trelstar)、呑皆克(Twinject)、Trivaris(醋酸曲安奈德可注射悬浮液)、Trisenox(三氧化二砷注射剂)、双福立适(Twinrix)、伤寒Vi疫苗(Typhoid Vi)、优维显(碘普罗胺注射剂)、注射用尿促卵泡素(麦处定)、尿激酶注射剂(Kinlytic)、优特金单抗(Stelara注射剂)、特慢胰岛素(Ultralente)(U)、安定(Valium)(地西泮)、丙戊酸钠注射剂(的帕肯)、Valtropin(生长激素注射剂)、盐酸万古霉素(盐酸万古霉素注射剂)、盐酸万古霉素注射剂(盐酸万古霉素)、Vaprisol(盐酸考尼伐坦注射剂)、VAQTA、Vasovist(用于静脉输注使用的钆磷维塞三钠注射剂)、Vectibix(静脉输注用帕尼单抗注射剂)、Venofer(蔗糖铁注射剂)、维替泊芬注射剂(Visudyne)、Vibativ(注射用特拉万星)、诺和力(Victoza)(利拉鲁肽[rDNA]注射剂)、Vimpat(拉科酰胺片和注射剂)、硫酸长春碱(硫酸长春碱注射剂)、Vincasar PFS(硫酸长春新碱注射剂)、诺和力、硫酸长春新碱(硫酸长春新碱注射剂)、Visudyne(维替泊芬注射剂)、维生素B-12、Vivitrol(纳曲酮XR注射剂)、Voluven(氯化钠中的羟乙基淀粉注射剂)、希罗达(Xeloda)、赛尼可(奥利司他)、Xeomin(inco肉毒杆菌毒素A型注射用)、索雷尔(Xolair)、Zantac注射剂(盐酸雷尼替丁注射剂)、Zemplar注射剂(帕立骨化醇注射剂触发瓶)、Zemuron(罗库溴铵注射剂)、Zenapax(达利珠单抗)、泽娃灵(Zevalin)、齐多夫定注射剂(立妥威IV)、希舒美注射剂(阿奇霉素)、Zn-DTPA(喷替酸锌钠注射剂)、枢复宁注射剂(盐酸昂丹司琼注射剂)、琴果(Zingo)、注射用唑来膦酸(择泰(Zometa))、唑来膦酸注射剂(Reclast)、择泰(注射用唑来膦酸)、Zosyn(哌拉西林和他唑巴坦注射剂)、Zyprexa Relprevv(奥氮平缓释剂可注射悬浮液)和它们的组合。
注意
上文已大致地和参考特定实施例地描述了本申请的发明。本领域技术人员将明了的是,在不偏离本公开的范围的情况下,可对各实施例进行各种改型和改变。因此,各实施例旨在覆盖本发明的改型和变型,只要他们落入所附权利要求书及其等同物的范围内即可。
Claims (29)
1.一种用于制造注入器装置的方法,所述方法包括:
将所述注入器装置的止挡件定位在管状构件中,使得所述止挡件的外侧与所述管状构件的内表面接合;以及
通过引起所述止挡件和所述管状构件之间的相对运动来修改止挡件的外侧,所述相对运动包括旋转运动和振动运动中的一者或两者。
2.如权利要求1所述的方法,其特征在于,所述管状构件是所述注入器装置的针筒。
3.如权利要求1所述的方法,其特征在于,所述管状构件是构造成插入到所述注入器装置的针筒中的通气管,所述通气管构造成用于将所述止挡件递送到所述注入器装置的针筒中。
4.如前述权利要求中任一项所述的方法,其特征在于,所述止挡件的外侧限定肋部,并且所述止挡件和所述管状构件之间的相对运动导致所述肋部处的局部加热。
5.如前述权利要求中任一项所述的方法,其特征在于,所述相对运动导致所述止挡件的外侧的粗糙度减小。
6.如前述权利要求中任一项所述的方法,其特征在于,所述止挡件的外侧包括褶皱,并且所述相对运动导致所述褶皱减少。
7.如前述权利要求中任一项所述的方法,其特征在于,所述止挡件的外侧限定沿纵向方向和周向方向的粗糙度,并且进一步其中,所述相对运动导致沿所述纵向方向和/或所述周向方向的粗糙度的减小。
8.如前述权利要求中任一项所述的方法,其特征在于,所述相对运动导致材料从所述止挡件的外侧转移至所述管状构件的内表面。
9.如前述权利要求中任一项所述的方法,其特征在于,所述止挡件的外侧包括聚合物材料,并且所述相对运动引发所述聚合物材料的聚合物运动。
10.如前述权利要求中任一项所述的方法,其特征在于,所述止挡件包括由第一材料形成的屏障和由第二材料形成的本体,所述屏障联接至所述本体。
11.如前述权利要求中任一项所述的方法,其特征在于,所述止挡件的外侧包括含氟聚合物材料。
12.如前述权利要求中任一项所述的方法,其特征在于,所述止挡件和所述管状构件之间的所述相对运动包括纵向分量。
13.一种用于制造注入器装置的方法,所述方法包括:
将所述注入器装置的止挡件定位在通气管中;
将所述通气管插入到所述注入器装置的针筒中;
将所述止挡件从所述通气管递送到所述注入器装置的针筒中,使得所述止挡件的外侧与所述针筒的内表面接合,以在所述止挡件的外侧与所述针筒的内表面之间限定密封界面;以及
引发所述止挡件和所述针筒之间的相对运动,以增强所述止挡件的外侧和所述针筒的内表面之间的密封界面。
14.如权利要求13所述的方法,其特征在于,所述止挡件和所述管状构件之间的所述相对运动包括旋转分量。
15.如权利要求13或14所述的方法,其特征在于,所述止挡件和所述管状构件之间的所述相对运动包括纵向分量。
16.如权利要求13至15中任一项所述的方法,其特征在于,所述止挡件的外侧包括聚合物材料,并且增强所述止挡件的外侧与所述针筒的内表面之间的所述密封界面包括引发所述聚合物材料在所述密封界面处的聚合物运动。
17.如权利要求13至16中任一项所述的方法,其特征在于,在将所述止挡件从所述通气管递送到所述注入器装置的所述针筒中之后,所述止挡件的外侧包括在所述密封界面处起皱,并且进一步其中,增强所述止挡件的外侧和所述针筒的内表面之间的所述密封界面包括减少在所述密封界面处的起皱。
18.如权利要求13至17中任一项所述的方法,其特征在于,所述止挡件包括本体和联接至所述本体的屏障,所述屏障由含氟聚合物材料形成,并且进一步其中,增强所述止挡件的外侧和所述针筒的内表面之间的所述密封界面包括在所述密封界面处引起局部加热。
19.如权利要求13至18中任一项所述的方法,其特征在于,增强所述止挡件的外侧和所述针筒的内表面之间的所述密封界面包括将材料从所述止挡件的外侧转移至所述针筒的内侧。
20.如权利要求13至19中任一项所述的方法,其特征在于,所述止挡件的外侧限定肋部并且所述密封界面包括所述止挡件的肋部。
21.一种注入器装置,包括:
止挡件,所述止挡件具有外侧并包括本体以及由与所述本体不同的材料形成的屏障,所述屏障联接至所述本体,所述屏障限定所述止挡件的外侧的至少一部分;以及
针筒,所述针筒具有内表面,所述内表面与所述止挡件的外侧接合以限定密封界面,所述针筒的内表面包括在所述密封界面处对应于所述屏障的材料的沉积的材料,使得所述密封界面由所述沉积的材料和所述屏障的材料限定,所述沉积的材料具有方向性定向。
22.如权利要求21所述的注入器装置,其特征在于,所述方向性定向包括周向分量。
23.如权利要求21或22所述的注入器装置,其特征在于,所述沉积的材料的所述方向性定向由沿共同方向对准的PTFE链的多个行限定。
24.如权利要求21至23中任一项所述的注入器装置,其特征在于,所述止挡件的外侧包括在所述密封界面处的微肋部和宏观肋部中的至少一个。
25.如权利要求21至24中任一项所述的注入器装置,其特征在于,所述屏障包括含氟聚合物材料。
26.如权利要求21至25中任一项所述的注入器装置,其特征在于,所述沉积的材料填充所述针筒的内表面中的一个或多个缺陷。
27.如权利要求21至26中任一项所述的注入器装置,其特征在于,所述沉积的材料仅位于所述密封界面处。
28.如权利要求21至27中任一项所述的注入器装置,其特征在于,所述密封界面对应于一个或多个周向带,其中所述止挡件的外侧接合所述针筒的内表面。
29.如权利要求21至28中任一项所述的注入器装置,其特征在于,所述沉积的材料在所述针筒的内侧上限定一个或多个周向带。
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2021/047959 WO2023027729A1 (en) | 2021-08-27 | 2021-08-27 | Injector device component surface modification |
Publications (1)
Publication Number | Publication Date |
---|---|
CN117881446A true CN117881446A (zh) | 2024-04-12 |
Family
ID=78087465
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202180101884.8A Pending CN117881446A (zh) | 2021-08-27 | 2021-08-27 | 注入器装置部件表面修改 |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP4392105A1 (zh) |
KR (1) | KR20240049599A (zh) |
CN (1) | CN117881446A (zh) |
AU (1) | AU2021461551A1 (zh) |
CA (1) | CA3227720A1 (zh) |
WO (1) | WO2023027729A1 (zh) |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5374473A (en) | 1992-08-19 | 1994-12-20 | W. L. Gore & Associates, Inc. | Dense polytetrafluoroethylene articles |
AU4408693A (en) | 1992-12-10 | 1994-07-04 | W.L. Gore & Associates, Inc. | Composite article |
DE69428056T2 (de) | 1994-09-02 | 2002-01-03 | Gore & Ass | Poröse polytetrafluorethylen zusammensetzungen |
DE69428914T2 (de) | 1994-10-31 | 2002-04-04 | Gore & Ass | Steifes blattförmiges polytetrafluoräthylenmaterial |
US5792525A (en) | 1995-03-31 | 1998-08-11 | W. L. Gore & Associates, Inc. | Creep resistant shaped article of densified expanded polytetrafluoroethylene |
US5772755A (en) | 1996-08-01 | 1998-06-30 | W. L. Gore & Associates, Inc. | Oriented crystalline materials |
US6541589B1 (en) | 2001-10-15 | 2003-04-01 | Gore Enterprise Holdings, Inc. | Tetrafluoroethylene copolymer |
AU2003277671A1 (en) * | 2002-11-11 | 2004-06-03 | Terumo Kabushiki Kaisha | Gasket and syringe |
US20050238872A1 (en) | 2004-04-23 | 2005-10-27 | Kennedy Michael E | Fluoropolymer barrier material |
US7531611B2 (en) | 2005-07-05 | 2009-05-12 | Gore Enterprise Holdings, Inc. | Copolymers of tetrafluoroethylene |
US8637144B2 (en) | 2007-10-04 | 2014-01-28 | W. L. Gore & Associates, Inc. | Expandable TFE copolymers, method of making, and porous, expended articles thereof |
US8658707B2 (en) | 2009-03-24 | 2014-02-25 | W. L. Gore & Associates, Inc. | Expandable functional TFE copolymer fine powder, the expanded functional products obtained therefrom and reaction of the expanded products |
US9139669B2 (en) | 2009-03-24 | 2015-09-22 | W. L. Gore & Associates, Inc. | Expandable functional TFE copolymer fine powder, the expandable functional products obtained therefrom and reaction of the expanded products |
EP3556412B1 (en) | 2009-10-29 | 2021-04-14 | W.L. Gore & Associates Inc. | Syringe stopper coated with expanded ptfe |
US9597458B2 (en) | 2009-10-29 | 2017-03-21 | W. L. Gore & Associates, Inc. | Fluoropolymer barrier materials for containers |
US11612697B2 (en) | 2010-10-29 | 2023-03-28 | W. L. Gore & Associates, Inc. | Non-fluoropolymer tie layer and fluoropolymer barrier layer |
EP2951235B1 (en) | 2013-01-30 | 2017-08-30 | W. L. Gore & Associates, Inc. | Method for producing porous articles from ultra high molecular weight polyethylene |
US9732184B2 (en) | 2014-07-29 | 2017-08-15 | W. L. Gore & Associates, Inc. | Process for producing articles formed from polylactic acid and articles made therefrom |
US9441088B2 (en) | 2014-07-29 | 2016-09-13 | W. L. Gore & Associates, Inc. | Articles produced from VDF-co-(TFE or TrFE) polymers |
US20160032069A1 (en) | 2014-07-29 | 2016-02-04 | W. L. Gore & Associates, Inc. | Porous Articles Formed From Polyparaxylylene and Processes For Forming The Same |
US10369292B2 (en) * | 2016-01-15 | 2019-08-06 | W. L. Gore & Associates, Inc. | Syringe plunger assemblies |
JP6919793B2 (ja) | 2016-04-15 | 2021-08-18 | 住友ゴム工業株式会社 | ガスケットおよび医療用注射器 |
SG11202008540WA (en) | 2018-03-06 | 2020-10-29 | Gore & Ass | Medical delivery devices having low lubricant hydrophobic syringe barrels |
JP7106676B2 (ja) * | 2018-04-24 | 2022-07-26 | ダブリュ.エル.ゴア アンド アソシエイツ,インコーポレイティド | 抑制された酸素透過性を有するメディカルデリバリーデバイス |
-
2021
- 2021-08-27 AU AU2021461551A patent/AU2021461551A1/en active Pending
- 2021-08-27 CA CA3227720A patent/CA3227720A1/en active Pending
- 2021-08-27 CN CN202180101884.8A patent/CN117881446A/zh active Pending
- 2021-08-27 KR KR1020247010057A patent/KR20240049599A/ko unknown
- 2021-08-27 EP EP21790606.4A patent/EP4392105A1/en active Pending
- 2021-08-27 WO PCT/US2021/047959 patent/WO2023027729A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
AU2021461551A1 (en) | 2024-02-22 |
WO2023027729A1 (en) | 2023-03-02 |
CA3227720A1 (en) | 2023-03-02 |
EP4392105A1 (en) | 2024-07-03 |
KR20240049599A (ko) | 2024-04-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR102635804B1 (ko) | 저 활택제 시린지 배럴을 갖는 의료용 전달 장치 | |
KR102240814B1 (ko) | 주사기 플런저 어셈블리 | |
CN112657021B (zh) | 具有层压塞的药物递送装置 | |
US11020531B2 (en) | Silicone free drug delivery devices | |
KR102522347B1 (ko) | 산소 투과가 억제된 의료용 전달 장치 | |
KR102579597B1 (ko) | 무윤활 스토퍼를 무윤활 배럴 또는 무윤활 카트리지 튜브에 삽입하는 방법 및 그 조립을 위한 시스템 | |
CN117881446A (zh) | 注入器装置部件表面修改 | |
CN117881445A (zh) | 具有可激活层的注入器装置止挡件 | |
CN117881447A (zh) | 注入器装置止挡件特征的形成 | |
CN117881444A (zh) | 注入器装置止挡件特征的重新成形 | |
CN117940182A (zh) | 注入器装置部件的通过针筒的加工 | |
CA3178104A1 (en) | A method of inserting a lubricant free stopper into a lubricant free barrel or a lubricant free cartridge tube and a system for assembling same |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination |