CN117814256A - Hypochlorous acid disinfectant composition for livestock and poultry and preparation method thereof - Google Patents
Hypochlorous acid disinfectant composition for livestock and poultry and preparation method thereof Download PDFInfo
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- CN117814256A CN117814256A CN202311809238.4A CN202311809238A CN117814256A CN 117814256 A CN117814256 A CN 117814256A CN 202311809238 A CN202311809238 A CN 202311809238A CN 117814256 A CN117814256 A CN 117814256A
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- QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical compound ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 title claims abstract description 43
- 239000000203 mixture Substances 0.000 title claims abstract description 35
- 239000000645 desinfectant Substances 0.000 title claims abstract description 34
- 244000144972 livestock Species 0.000 title claims abstract description 22
- 244000144977 poultry Species 0.000 title claims abstract description 22
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- KKEYFWRCBNTPAC-UHFFFAOYSA-N Terephthalic acid Chemical compound OC(=O)C1=CC=C(C(O)=O)C=C1 KKEYFWRCBNTPAC-UHFFFAOYSA-N 0.000 claims abstract description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 30
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 21
- 239000002105 nanoparticle Substances 0.000 claims abstract description 17
- BSYNRYMUTXBXSQ-FOQJRBATSA-N 59096-14-9 Chemical compound CC(=O)OC1=CC=CC=C1[14C](O)=O BSYNRYMUTXBXSQ-FOQJRBATSA-N 0.000 claims abstract description 15
- 239000007853 buffer solution Substances 0.000 claims abstract description 15
- 239000002994 raw material Substances 0.000 claims abstract description 8
- 239000003093 cationic surfactant Substances 0.000 claims abstract description 7
- 238000000498 ball milling Methods 0.000 claims description 28
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 16
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 16
- NUJOXMJBOLGQSY-UHFFFAOYSA-N manganese dioxide Chemical compound O=[Mn]=O NUJOXMJBOLGQSY-UHFFFAOYSA-N 0.000 claims description 16
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 12
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 12
- 239000008367 deionised water Substances 0.000 claims description 12
- 229910021641 deionized water Inorganic materials 0.000 claims description 12
- 239000000463 material Substances 0.000 claims description 12
- 238000002156 mixing Methods 0.000 claims description 12
- 239000002245 particle Substances 0.000 claims description 12
- 239000000377 silicon dioxide Substances 0.000 claims description 8
- 238000005245 sintering Methods 0.000 claims description 8
- 239000004408 titanium dioxide Substances 0.000 claims description 8
- 235000012239 silicon dioxide Nutrition 0.000 claims description 7
- WOWHHFRSBJGXCM-UHFFFAOYSA-M cetyltrimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+](C)(C)C WOWHHFRSBJGXCM-UHFFFAOYSA-M 0.000 claims description 6
- 238000006243 chemical reaction Methods 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 5
- AMQJEAYHLZJPGS-UHFFFAOYSA-N N-Pentanol Chemical compound CCCCCO AMQJEAYHLZJPGS-UHFFFAOYSA-N 0.000 claims description 4
- VBIIFPGSPJYLRR-UHFFFAOYSA-M Stearyltrimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)C VBIIFPGSPJYLRR-UHFFFAOYSA-M 0.000 claims description 4
- HTZCNXWZYVXIMZ-UHFFFAOYSA-M benzyl(triethyl)azanium;chloride Chemical compound [Cl-].CC[N+](CC)(CC)CC1=CC=CC=C1 HTZCNXWZYVXIMZ-UHFFFAOYSA-M 0.000 claims description 4
- 239000000872 buffer Substances 0.000 claims description 4
- SXPWTBGAZSPLHA-UHFFFAOYSA-M cetalkonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 SXPWTBGAZSPLHA-UHFFFAOYSA-M 0.000 claims description 4
- 229960000228 cetalkonium chloride Drugs 0.000 claims description 4
- NHGXDBSUJJNIRV-UHFFFAOYSA-M tetrabutylammonium chloride Chemical compound [Cl-].CCCC[N+](CCCC)(CCCC)CCCC NHGXDBSUJJNIRV-UHFFFAOYSA-M 0.000 claims description 4
- CEYYIKYYFSTQRU-UHFFFAOYSA-M trimethyl(tetradecyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCC[N+](C)(C)C CEYYIKYYFSTQRU-UHFFFAOYSA-M 0.000 claims description 4
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 2
- 241000208818 Helianthus Species 0.000 claims description 2
- 235000003222 Helianthus annuus Nutrition 0.000 claims description 2
- 239000008351 acetate buffer Substances 0.000 claims description 2
- HPXRVTGHNJAIIH-UHFFFAOYSA-N cyclohexanol Chemical compound OC1CCCCC1 HPXRVTGHNJAIIH-UHFFFAOYSA-N 0.000 claims description 2
- REZZEXDLIUJMMS-UHFFFAOYSA-M dimethyldioctadecylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CCCCCCCCCCCCCCCCCC REZZEXDLIUJMMS-UHFFFAOYSA-M 0.000 claims description 2
- DDXLVDQZPFLQMZ-UHFFFAOYSA-M dodecyl(trimethyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+](C)(C)C DDXLVDQZPFLQMZ-UHFFFAOYSA-M 0.000 claims description 2
- 239000008363 phosphate buffer Substances 0.000 claims description 2
- SNNIPOQLGBPXPS-UHFFFAOYSA-M tetraoctylazanium;chloride Chemical compound [Cl-].CCCCCCCC[N+](CCCCCCCC)(CCCCCCCC)CCCCCCCC SNNIPOQLGBPXPS-UHFFFAOYSA-M 0.000 claims description 2
- ILWRPSCZWQJDMK-UHFFFAOYSA-N triethylazanium;chloride Chemical compound Cl.CCN(CC)CC ILWRPSCZWQJDMK-UHFFFAOYSA-N 0.000 claims description 2
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 25
- 230000001954 sterilising effect Effects 0.000 description 12
- 239000000243 solution Substances 0.000 description 10
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 5
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
- 230000009471 action Effects 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- 241000222122 Candida albicans Species 0.000 description 3
- 241000991587 Enterovirus C Species 0.000 description 3
- 241000191967 Staphylococcus aureus Species 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 229940095731 candida albicans Drugs 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- WQYVRQLZKVEZGA-UHFFFAOYSA-N hypochlorite Inorganic materials Cl[O-] WQYVRQLZKVEZGA-UHFFFAOYSA-N 0.000 description 3
- -1 hypochlorite ions Chemical class 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 238000004061 bleaching Methods 0.000 description 2
- 239000000460 chlorine Substances 0.000 description 2
- 229910052801 chlorine Inorganic materials 0.000 description 2
- 239000002316 fumigant Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 239000005708 Sodium hypochlorite Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- XTEGARKTQYYJKE-UHFFFAOYSA-N chloric acid Chemical compound OCl(=O)=O XTEGARKTQYYJKE-UHFFFAOYSA-N 0.000 description 1
- 229940005991 chloric acid Drugs 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 235000012055 fruits and vegetables Nutrition 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 230000033116 oxidation-reduction process Effects 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 238000006479 redox reaction Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000007785 strong electrolyte Substances 0.000 description 1
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention belongs to the technical field of disinfection, and particularly relates to a hypochlorous acid disinfectant composition for livestock and poultry and a preparation method thereof. The invention discloses a hypochlorous acid disinfectant composition for livestock and poultry, which comprises the following raw material components in percentage by weight: 10-15% of hypochlorous acid, 3-8% of acetylsalicylic acid, 2-4% of organic alcohol, 1-3% of cationic surfactant, 0.1-0.3% of terephthalic acid, 0.05-0.1% of buffer solution, 2-10% of nano particles and the balance of water. The invention also discloses a preparation method of the disinfectant. The disinfectant has low cost and can be used for large-area disinfection of livestock, poultry and places.
Description
Technical Field
The invention belongs to the technical field of disinfection, and particularly relates to a hypochlorous acid disinfectant composition for livestock and poultry and a preparation method thereof.
Background
Chloric acid is an oxyacid of chlorine element, and has a chemical formula of HOCl and a structural formula of H-O-Cl, wherein the valence of the chlorine element is +1. It is present only in solution, its concentrated solution is yellow, its diluted solution is colorless, has a very sharp, chlorine-like smell, and is very unstable, is a very weak acid, is weaker than carbonic acid, and is comparable to hydrogen sulfuric acid. Hypochlorous acid also has a very strong bleaching action, and its salts can be used as bleaching and disinfectant. When used as disinfectant, the disinfectant is widely used for disinfecting polluted articles such as object surfaces, fabrics and the like, water, fruits and vegetables, drinking tools and the like. In addition to the above uses, hypochlorous acid can also be used for disinfection of indoor air, secondary water supply equipment surfaces, hands, skin and mucous membranes.
Sodium hypochlorite is a strong electrolyte, firstly ionizes in water to generate hypochlorite ions, and if the hypochlorite ions hydrolyze, hypochlorous acid can be generated, the hypochlorite ions are further decomposed to generate nascent oxygen, and the nascent oxygen has very active chemical property and very strong oxidizing power and plays a great role in the disinfection process. The disinfection principle of the hypochlorous acid disinfectant is that hypochlorous acid causes bacteria to be cracked through oxidation-reduction action with bacterial cell walls and virus shells. The hypochlorous acid has the oxidability, so that the compound can kill gram positive and negative bacteria through oxidation-reduction reaction at a lower concentration, has no irritation, sensitization and corrosion to mammals, is a mild broad-spectrum bactericide, and has wide application.
Currently, disinfectants commonly used in farms include liquid disinfectants and solid fumigants. In the large-scale cultivation process, the space is generally disinfected in all directions by spraying and sterilizing liquid disinfectant and then rapidly releasing sterilizing gas by using solid fumigant. The liquid disinfectant is used as a common disinfection form and has wide application due to the advantage of low cost. Therefore, a hypochlorous acid disinfectant composition for livestock and poultry and a preparation method thereof are expected.
Disclosure of Invention
The invention aims to overcome the problems in the prior art and provides a hypochlorous acid disinfectant composition for livestock and poultry and a preparation method thereof. The disinfectant has low cost and can be used for large-area disinfection of livestock, poultry and places.
The aim and the technical problems of the invention are realized by adopting the following technical proposal.
The invention provides a hypochlorous acid disinfectant composition for livestock and poultry, which comprises the following raw material components in percentage by weight: 10-15% of hypochlorous acid, 3-8% of acetylsalicylic acid, 2-4% of organic alcohol, 1-3% of cationic surfactant, 0.1-0.3% of terephthalic acid, 0.05-0.1% of buffer solution, 2-10% of nano particles and the balance of water.
Preferably, the organic alcohol is selected from any one or a combination of more of ethanol, glycerol, butanol, cyclohexanol, pentanol.
Preferably, the cationic surfactant is selected from at least one of cetyltrimethylammonium chloride, octadecyltrimethylammonium chloride, cetylbenzyldimethylammonium chloride, tetradecyltrimethylammonium chloride, dodecyltrimethylammonium chloride, tetrabutylammonium chloride, dioctadecyldimethylammonium chloride, sunflower-based triethylammonium chloride, tetraoctylammonium chloride, benzyltriethylammonium chloride.
Preferably, the buffer is selected from at least one of phosphate buffer, acetate buffer or carbonate buffer.
Preferably, the preparation method of the nano-particles comprises the following steps:
evenly mixing 80-200 meshes of manganese dioxide, silicon dioxide and titanium dioxide, adding deionized water for ball milling for one time, sintering the materials at high temperature after ball milling, and cooling to room temperature after reaction is finished;
adding deionized water into the obtained product to perform secondary ball milling, and drying the material after ball milling is finished to obtain particles with the particle size of 100-400 nm.
Preferably, the manganese dioxide, the silicon dioxide and the titanium dioxide are mixed according to the mass ratio of 1:2-10:1-3.
Preferably, the primary ball milling conditions are: the rotating speed is 40-50 r/min, and the time is 2-6h.
Preferably, the sintering conditions are: the temperature is 800-1200 ℃ and the time is 4-10h.
Preferably, the secondary ball milling conditions are: 40-50 r/min for 1-3h.
The invention also provides a method for preparing the composition, which comprises the steps of uniformly mixing hypochlorous acid, acetylsalicylic acid, organic alcohol, cationic surfactant, terephthalic acid, buffer solution and water according to a proportion, and uniformly dispersing nano particles by ultrasonic waves.
By means of the technical scheme, the invention has at least the following advantages: the hypochlorous acid disinfectant disclosed by the invention is a composition product with good stability and good disinfection effect, wherein hypochlorous acid is taken as a main active substance, nano particles are taken as a carrier, and the composition with good disinfection effect is formed by combination. The composition of the invention has simple preparation process and low cost of disinfectant, and can be used for large-area disinfection of livestock and poultry and places.
The foregoing description is only an overview of the present invention, and is intended to provide a more thorough understanding of the present invention, and is to be accorded the full scope of the present invention.
Detailed Description
In order to make the technical means, the creation features, the achievement of the purposes and the effects of the present invention easy to understand, the technical solutions of the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Example 1:
the hypochlorous acid disinfectant composition for livestock and poultry comprises the following raw material components in percentage by weight: 12.5% of hypochlorous acid, 5.5% of acetylsalicylic acid, 3% of ethanol, 2% of hexadecyltrimethyl ammonium chloride, 0.2% of terephthalic acid, 0.075% of buffer solution, 6% of nano particles and the balance of water.
A preparation method of a hypochlorous acid disinfectant composition for livestock and poultry comprises the following steps:
evenly mixing 80-200 meshes of manganese dioxide, silicon dioxide and titanium dioxide according to the mass ratio of 1:6:2, adding deionized water, performing primary ball milling for 4 hours at the rotating speed of 45r/min, performing high-temperature sintering on the materials at 1000 ℃ for 7 hours after ball milling, and cooling to room temperature after the reaction is finished;
adding deionized water into the obtained product, performing secondary ball milling for 2 hours at the rotating speed of 45r/min, and drying the material after ball milling to obtain particles with the particle size of 100-400 nm;
uniformly mixing hypochlorous acid, acetylsalicylic acid, ethanol, cetyltrimethylammonium chloride, terephthalic acid, phosphoric acid buffer solution and water according to the proportion, and uniformly dispersing nano particles by ultrasonic.
Example 2:
the hypochlorous acid disinfectant composition for livestock and poultry comprises the following raw material components in percentage by weight: 15% of hypochlorous acid, 3% of acetylsalicylic acid, 2% of glycerol, 1% of octadecyl trimethyl ammonium chloride, 0.1% of terephthalic acid, 0.1% of acetic acid buffer solution, 2% of nano particles and the balance of water.
A preparation method of a hypochlorous acid disinfectant composition for livestock and poultry comprises the following steps:
evenly mixing 80-200 meshes of manganese dioxide, silicon dioxide and titanium dioxide according to the mass ratio of 1:2:1, adding deionized water, performing primary ball milling for 2 hours at the rotating speed of 50r/min, performing high-temperature sintering on the materials at 1200 ℃ for 4 hours after ball milling, and cooling to room temperature after the reaction is finished;
adding deionized water into the obtained product, performing secondary ball milling for 3 hours at the rotating speed of 40r/min, and drying the material after ball milling to obtain particles with the particle size of 100-400 nm;
uniformly mixing hypochlorous acid, acetylsalicylic acid, glycerol, octadecyl trimethyl ammonium chloride, terephthalic acid, acetic acid buffer solution and water according to the proportion, and uniformly dispersing nano particles by ultrasonic wave
Example 3:
the hypochlorous acid disinfectant composition for livestock and poultry comprises the following raw material components in percentage by weight: 10% of hypochlorous acid, 8% of acetylsalicylic acid, 4% of butanol, 3% of hexadecylbenzyl dimethyl ammonium chloride, 0.1% of terephthalic acid, 0.1% of carbonic acid buffer solution, 10% of nano particles and the balance of water.
A preparation method of a hypochlorous acid disinfectant composition for livestock and poultry comprises the following steps:
evenly mixing 80-200 meshes of manganese dioxide, silicon dioxide and titanium dioxide according to the mass ratio of 1:10:3, adding deionized water, performing primary ball milling for 6 hours at the rotating speed of 50r/min, performing high-temperature sintering on the materials at 800 ℃ for 10 hours after ball milling, and cooling to room temperature after the reaction is finished;
adding deionized water into the obtained product, performing secondary ball milling for 1h at the rotating speed of 50r/min, and drying the material after ball milling to obtain particles with the particle size of 100-400 nm;
uniformly mixing hypochlorous acid, acetylsalicylic acid, butanol, hexadecylbenzyl dimethyl ammonium chloride, terephthalic acid, carbonic acid buffer solution and water according to the proportion, and uniformly dispersing nano particles by ultrasonic.
Example 4:
the hypochlorous acid disinfectant composition for livestock and poultry comprises the following raw material components in percentage by weight: 12% of hypochlorous acid, 4% of acetylsalicylic acid, 3% of butanol, 2% of tetradecyltrimethylammonium chloride, 0.1% of terephthalic acid, 0.05% of carbonic acid buffer solution, 10% of nano particles and the balance of water.
A preparation method of a hypochlorous acid disinfectant composition for livestock and poultry comprises the following steps:
evenly mixing 80-200 meshes of manganese dioxide, silicon dioxide and titanium dioxide according to the mass ratio of 1:8:3, adding deionized water, performing primary ball milling for 4 hours at the rotating speed of 45r/min, performing high-temperature sintering on the materials at 800 ℃ for 10 hours after ball milling, and cooling to room temperature after the reaction is finished;
adding deionized water into the obtained product, performing secondary ball milling for 3 hours at the rotating speed of 40r/min, and drying the material after ball milling to obtain particles with the particle size of 100-400 nm;
uniformly mixing hypochlorous acid, acetylsalicylic acid, butanol, tetradecyl trimethyl ammonium chloride, terephthalic acid, carbonic acid buffer solution and water according to the proportion, and uniformly dispersing nano particles by ultrasonic.
Comparative example 1:
the hypochlorous acid disinfectant composition for livestock and poultry comprises the following raw material components in percentage by weight: 12.5% of hypochlorous acid, 5.5% of acetylsalicylic acid, 3% of ethanol, 2% of hexadecyltrimethyl ammonium chloride, 0.2% of terephthalic acid, 0.075% of buffer solution and the balance of water.
A preparation method of a hypochlorous acid disinfectant composition for livestock and poultry comprises the following steps:
uniformly mixing hypochlorous acid, acetylsalicylic acid, ethanol, cetyltrimethylammonium chloride, terephthalic acid, phosphoric acid buffer solution and water according to the proportion, and uniformly dispersing nano particles by ultrasonic.
Test example 1: detection of disinfection effects of different disinfection solutions
The experimental method comprises the following steps: the following sterilization and disinfection experiments of the strains and viruses were performed according to the method specified in the ministry of health, disinfection technical Specification (2002 edition), and the results were observed and recorded after 1min and 60min, respectively,
sterilization rate = (average number of bacteria of sample before sterilization-average number of bacteria of sample after sterilization)/average number of bacteria of sample before sterilization
Experimental results: see tables 1-2.
TABLE 1 Sterilization rate (%) detection result with 1min action time
| Numbering device | Coli bacterium | Staphylococcus aureus | Candida albicans | Poliovirus |
| Example 1 | 98.5 | 99.6 | 89.4 | 92.1 |
| Example 2 | 98.7 | 99.5 | 89.1 | 92.4 |
| Example 3 | 98.3 | 99.6 | 89.3 | 91.7 |
| Example 4 | 98.4 | 99.5 | 89.2 | 91.2 |
| Comparative example 1 | 87.2 | 89.8 | 85.2 | 84.2 |
Table 2 results of detection of sterilization and disinfection rate (%) with an action time of 60 minutes
| Numbering device | Coli bacterium | Staphylococcus aureus | Candida albicans | Poliovirus |
| Example 1 | Greater than 99.99 | Greater than 99.99 | Greater than 99.99 | Greater than 99.99 |
| Example 2 | Greater than 99.99 | Greater than 99.99 | Greater than 99.99 | Greater than 99.99 |
| Example 3 | Greater than 99.99 | Greater than 99.99 | Greater than 99.99 | Greater than 99.99 |
| Example 4 | Greater than 99.99 | Greater than 99.99 | Greater than 99.99 | Greater than 99.99 |
| Comparative example 1 | 89.5 | 85.1 | 86.8 | 89.7 |
As can be seen from the results of tables 1 and 2, the disinfectant of the present invention (examples 1 to 3) has the advantages of good sterilization effect and long sterilization time as compared with comparative example 1.
Test example 2: disinfectant stability detection
The sterilizing solutions prepared in examples 1 to 4 were stored at 37℃in an incubator, and the appearance of the composition was not changed after 180 days of storage.
The composition of examples 1-4 stored for 180 days is subjected to a sterilization experiment, and the sterilization rate of staphylococcus aureus, escherichia coli, candida albicans and poliovirus is more than 99.99% in 5 minutes, so that the composition still has a good sterilization effect.
While the invention has been described with respect to preferred embodiments, it will be understood by those skilled in the art that various changes and modifications may be made without departing from the spirit and scope of the invention, and that any such changes and modifications as described in the above embodiments are intended to be within the scope of the invention.
Claims (10)
1. The hypochlorous acid disinfectant composition for livestock and poultry is characterized by comprising the following raw material components in percentage by weight: 10-15% of hypochlorous acid, 3-8% of acetylsalicylic acid, 2-4% of organic alcohol, 1-3% of cationic surfactant, 0.1-0.3% of terephthalic acid, 0.05-0.1% of buffer solution, 2-10% of nano particles and the balance of water.
2. The composition of claim 1, wherein the organic alcohol is selected from any one or a combination of more of ethanol, glycerol, butanol, cyclohexanol, pentanol.
3. The composition of claim 1, wherein the cationic surfactant is selected from at least one of cetyltrimethylammonium chloride, octadecyltrimethylammonium chloride, cetylbenzyldimethylammonium chloride, tetradecyltrimethylammonium chloride, dodecyltrimethylammonium chloride, tetrabutylammonium chloride, dioctadecyldimethylammonium chloride, sunflower-based triethylammonium chloride, tetraoctylammonium chloride, benzyltriethylammonium chloride.
4. The composition of claim 1, wherein the buffer is selected from at least one of a phosphate buffer, an acetate buffer, or a carbonate buffer.
5. The composition of claim 1, wherein the nanoparticle preparation method comprises the following steps:
evenly mixing 80-200 meshes of manganese dioxide, silicon dioxide and titanium dioxide, adding deionized water for ball milling for one time, sintering the materials at high temperature after ball milling, and cooling to room temperature after reaction is finished;
adding deionized water into the obtained product to perform secondary ball milling, and drying the material after ball milling is finished to obtain particles with the particle size of 100-400 nm.
6. The composition according to claim 1, wherein the manganese dioxide, silica, titanium dioxide are mixed in an amount of 1:2-10:1-3 by mass ratio.
7. The composition of claim 1, wherein the primary ball milling conditions are: the rotating speed is 40-50 r/min, and the time is 2-6h.
8. The composition of claim 1, wherein the sintering conditions are: the temperature is 800-1200 ℃ and the time is 4-10h.
9. The composition of claim 1, wherein the secondary ball milling conditions are: 40-50 r/min for 1-3h.
10. A method for preparing the composition of any one of claims 1-9, wherein hypochlorous acid, acetylsalicylic acid, organic alcohol, cationic surfactant, terephthalic acid, buffer solution and water are uniformly mixed according to the proportion, and then nano-particles are uniformly dispersed by ultrasonic.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311809238.4A CN117814256A (en) | 2023-12-26 | 2023-12-26 | Hypochlorous acid disinfectant composition for livestock and poultry and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311809238.4A CN117814256A (en) | 2023-12-26 | 2023-12-26 | Hypochlorous acid disinfectant composition for livestock and poultry and preparation method thereof |
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