CN117752758A - Traditional Chinese medicine composition for treating distention and fullness and application thereof - Google Patents
Traditional Chinese medicine composition for treating distention and fullness and application thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a traditional Chinese medicine composition for treating distention and fullness and application thereof. The traditional Chinese medicine composition comprises vinegar-processed bupleurum, white peony root, jasmine flower, radix curcumae, radix pseudostellariae, five-finger wild peach, poria with hostwood, cortex albiziae, exocarpium citri rubrum, chicken bone fragrance, sandalwood, fiveleaf akebia fruit, fructus amomi, cardamom, perilla stem, pericarpium arecae, reed rhizome, bamboo shavings, radix strigae Asiaticae, fried rice sprout, charcoal, dreg leaf and radix salviae miltiorrhizae. The traditional Chinese medicine composition provided by the invention has the effects of resolving depression and tranquillizing, strengthening spleen and tonifying qi, and relieving stuffiness and eliminating fullness, follows the principles of ' both symptoms and signs are the same and ' treating disease and solving the root cause ', accords with the principle of compatibility of monarch, minister, assistant and guide of traditional Chinese medicines, has unique curative effects on chronic gastritis, functional dyspepsia and gastrointestinal neurosis of syndrome differentiation of liver depression and spleen deficiency, does not have adverse reaction, is safe and effective, and is suitable for popularization and application.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicine preparations. More particularly relates to a traditional Chinese medicine composition for treating distention and fullness and application thereof.
Background
Distention and fullness is a disease with distention and discomfort of the stomach and abdomen as the main symptoms, which are manifested by subjective distention and fullness, softness, intangible touch and painless pressure. "Jingyue Quanshu, glomus and full" has clouds: the term "distension and fullness in the abdomen and stuffiness in the abdomen" means that the distension and fullness in the abdomen is not open; the symptoms of fullness are that the fullness is not going. The patient is close to distending after full covering, and the patient does not need to distend. The diseases such as chronic gastritis, functional dyspepsia, gastrointestinal neurosis and the like in modern medicine can be included in the category of distention and fullness. The theory of traditional Chinese medicine holds that: distention and fullness is caused by comprehensive factors such as invasion of exogenous evil, improper diet, phlegm-dampness stagnation, emotional disorder and weakness of spleen and stomach, and is marked by spleen deficiency and deficiency, qi stagnation, fire heat, food stagnation and phlegm retention. With the increase of pressure in various aspects of society, work, life and the like and the change of eating habits and work and rest laws, more and more people suffer from diseases of spleen and stomach systems. Among them, the incidence of distention and fullness is the vast majority of patients in the spleen and stomach department. Moreover, the disease is easy to persist and repeat, which not only damages the physical and mental health of patients, but also aggravates the economic burden of the patients, thereby reducing the life quality of the patients.
The chronic gastritis refers to various chronic gastric mucosal inflammatory lesions caused by different causes, is the most common digestive system disease of people in China, and clinically has the most common chronic superficial gastritis, chronic erosive gastritis and chronic atrophic gastritis. According to a domestic large-scale cross-sectional survey, the composition ratio of chronic atrophic gastritis and chronic non-atrophic gastritis was 17.7% and 82.3%, respectively, in 8892 patients diagnosed with chronic gastritis by endoscope. Since most patients with chronic atrophic gastritis have no obvious digestive tract symptoms or do not undergo gastroscopy, the actual prevalence of chronic atrophic gastritis is probably higher, and the prevalence of chronic atrophic gastritis of the whole population in China is estimated to be higher than 20%. Most of chronic superficial gastritis can be reversed, and the small part can be converted into chronic atrophic gastritis. If not treated in time, chronic gastritis may develop into gastric ulcer, and even further induce complications such as gastrorrhagia, gastric perforation, pyloric obstruction, gastric cancer, etc.
Functional dyspepsia refers to a non-organic disease caused by dysfunction of the stomach and duodenum, and is manifested by symptoms such as postprandial fullness, early fullness, eructation, inappetence, nausea, emesis, etc., and is usually slow in onset, continuous or recurrent, and can be induced by dietary and mental factors. The incidence rate of functional dyspepsia is high, and investigation results show that the incidence rate of functional dyspepsia in China is 23%, accounts for as much as half of patients in the outpatient department of spleen and stomach, and has an ascending trend every year.
Gastrointestinal neurosis is a complex digestive system disease mainly caused by dysfunction of the autonomic nervous system due to dysfunction of higher nerve activity. The symptoms of patients are mainly belch, abdominal distention, acid regurgitation, nausea, early satiety and the like, but clinical examination shows that the patients have no organic lesions. If the disease is not improved for a long time, the life quality of patients is often affected.
Although chronic gastritis, functional dyspepsia and gastrointestinal neurosis are different in disease name, they are similar in disease name, and symptoms such as middle-upper abdomen discomfort, fullness, inappetence, eructation, pantothenic acid and nausea can occur, so that the chronic gastritis, functional dyspepsia and gastrointestinal neurosis can be clinically classified as "distention and fullness" in traditional Chinese medicine. Modern medicine is usually a four-way therapy, i.e. a combination therapy of a proton pump inhibitor, two antibiotics and a bismuth preparation (Yis Ma Yili.Thermomann, wen Ning, zengfang. The combination of traditional Chinese and Western medicine is a research progress in the treatment of chronic atrophic gastritis [ J ]. Xinjiang traditional Chinese medicine, 2023, 41 (04): 126-130). Proton pump inhibitors and gastric motility promoting medicines (Gu Xiaoyan. Decoction for strengthening spleen, regulating qi and relieving stuffiness) are used clinically for treating functional dyspepsia in combination with western medicine for treating functional dyspepsia, spleen deficiency and qi stagnation syndrome. For the gastrointestinal neurosis, the medicines such as gastric motility promoting medicines, gastric acid inhibiting medicines, intestinal flora regulating agents and the like are combined with psychological dredging for treatment in clinic (Liu Guanping. Clinical curative effect observation of the needle for treating the gastrointestinal neurosis [ D ]. Heilongjiang traditional Chinese medicine university, 2015). Most of modern medical methods for treating the three diseases are symptomatic treatment and only temporarily relieve the disease, but the problems of inaccurate curative effect, multiple side effects, poor patient tolerance and the like exist.
Disclosure of Invention
The invention aims to overcome the defects and shortcomings of the existing medicines such as unobvious curative effect, more side effects and poor tolerance of patients on the distention and fullness diseases and provides a traditional Chinese medicine composition for treating the distention and fullness. The traditional Chinese medicine composition accords with the compatibility principle of monarch, minister, assistant and guide, has the effects of resolving depression and tranquillization, strengthening spleen and tonifying qi, and relieving stuffiness and eliminating fullness, has unique curative effects on chronic gastritis, functional dyspepsia and gastrointestinal neurosis of syndrome differentiation of liver depression and spleen deficiency, and fully proves the principles of simultaneous treatment of different diseases and treatment of disease and root cause.
The invention aims to provide an application of a traditional Chinese medicine composition for treating distention and fullness in the preparation of a medicine for treating the distention and fullness due to liver depression and spleen deficiency.
The above object of the present invention is achieved by the following technical scheme:
the core pathogenesis of distention and fullness is the failure of liver to dredge and spleen to transport. Spleen and stomach are the center of the middle energizer and are the junction for ascending and descending of qi. Spleen governs transportation and transformation, stomach governs reception, and the spleen governs ascending clear and stomach governs descending turbid, and qi movement is smooth when clear ascending turbid descending. Liver governs smoothing flow of qi and regulates qi movement of spleen and stomach, and liver qi can promote spleen and stomach and smooth qi movement. Liver belongs to wood, spleen and stomach belongs to earth, and wood has the function of dispelling earth and the property of earth-resolving, so that earth is obtained from wood, for example, as reported in the theory of blood syndrome and viscera disease theory: the property of wood is to dredge and release food qi into stomach, and the property of wood depends on liver qi to dredge and release food qi. Liver-qi failing to drain liver-qi and affecting spleen-earth are the pathological condition of the liver, if liver-yang is not ascending, it will not drain food and drain spleen-qi. Qi deficiency of the spleen and stomach, failure of transportation and transformation, disturbance of ascending and descending of middle energizer, spleen failing to ascend and stomach qi failing to descend, stuffiness and blockage of qi movement, and thus qi stagnation and fullness. Therefore, disorder of spleen, stomach and liver can cause adverse qi movement of middle energizer, and spleen and stomach ascending and descending are not effective to cause deficiency and distention, so distention and fullness should be treated by liver and spleen theory. Clinical practice proves that the traditional Chinese medicine has the unique advantages of good curative effect and small toxic and side effects in the treatment of chronic gastritis, functional dyspepsia, gastrointestinal neurosis and other diseases in the category of distention and fullness.
Based on the above, the invention provides a traditional Chinese medicine composition for treating distention and fullness, which comprises the following raw materials in parts by weight: 3-10 parts of vinegar radix bupleuri, 6-15 parts of white peony root, 5-10 parts of jasmine flower, 5-12 parts of radix curcumae, 9-30 parts of radix pseudostellariae, 15-30 parts of five-finger wild peach, 9-15 parts of poria with hostwood, 6-15 parts of cortex albiziae, 3-6 parts of pummelo peel, 6-15 parts of chicken bone, 2-5 parts of sandalwood, 9-15 parts of fiveleaf akebia fruit, 3-6 parts of fructus amomi, 3-6 parts of cardamom, 5-10 parts of perilla stem, 5-10 parts of pericarpium arecae, 15-30 parts of reed rhizome, 5-10 parts of bamboo shavings, 5-25 parts of striga, 9-15 parts of stir-fried rice sprout, 9-15 parts of herb of Chinese knotweed, 15-30 parts of folium mori and 6-15 parts of radix salviae miltiorrhizae.
The Chinese medicinal composition of the invention comprises the following components:
in the recipe, vinegar-processed bupleurum root is good at soothing liver and regulating qi, raising yang and relieving exterior and interior, and Shennong Ben Cao Jing read (Shennong's herbal code) carries: the bupleurum root is light and clear, and reaches the gallbladder qi and the gallbladder qi is stripped, so that eleven viscera are dispersed from the bupleurum root, the heart, the abdomen and the intestines and the stomach can be dispersed from each other; the radix pseudostellariae has the effects of replenishing qi to invigorate the spleen, promoting the production of body fluid and moistening the lung, and the two medicines are taken as monarch medicines, so that the effects of soothing liver and relieving depression, and strengthening the spleen and replenishing qi are achieved. The five-finger wild peach has the effects of strengthening spleen and tonifying lung, and further helps radix pseudostellariae to strengthen spleen and replenish qi; white peony root is slightly bitter and slightly sour, enters liver meridian, nourishes blood and astringes yin, is slightly astringent, and vinegar radix bupleuri and white peony root are used for dispersing and astringing one, and complement each other, so that liver qi is not depressed, yin blood can be retained, liver is soothing without damaging yin blood, liver astringing without stagnating qi, and the two medicines are ministerial medicines, and assist monarch medicines in strengthening effects of soothing liver and Yu Yangyin and strengthening spleen and tonifying qi. Jasmine flower, radix curcumae, poria with hostwood, cortex albiziae, exocarpium citri rubrum, chicken bone, sandalwood, fiveleaf akebia fruit, fructus amomi, cardamom, perilla stem, pericarpium arecae, rhizoma phragmitis, caulis bambusae in taeniam, radix strigae Asiaticae, stir-fried rice sprout, herb of Chinese knotweed and leaf of cloth residue are used as adjuvant drugs, liver qi is lost to dredge, emotion is easy to depression, insomnia is difficult to sleep, and the jasmine flower and radix curcumae are applied to sooth liver and relieve depression and promote qi; poria and Albizia julibrissin Pi Ning are used for soothing nerves and aiding sleep; the spleen and stomach are ascending and descending for disorder, qi movement is blocked, and stomach and abdomen are full and uncomfortable, four ingredients of exocarpium citri rubrum, chicken bone fragrance, sandalwood and akebia fruit are used for regulating qi and relieving stuffiness; fructus Amomi is fragrant and fleeing for qi turbidity, fructus Amomi rotundus is fragrant and clear, and the two drugs are used together to ventilate the qi movement of the upper, middle and lower three-jiaos to promote the circulation of qi and smooth the chest, promote qi circulation and relieve pain, remove turbidity by aromatics, invigorate spleen and promote appetite, and promote digestion; the perilla stem is good at regulating qi and regulating middle energizer; the large abdomen has good descending property, eliminates dampness, stagnates qi, relieves the distention and enhances the effect of regulating qi, relieving the middle-jiao and relieving the distention by adding the two medicines; the reed rhizome has the effects of stimulating appetite and relieving vomiting, and the bamboo shavings have the effects of lowering adverse qi and relieving vomiting; the spleen and stomach are failing to transport and transform, so that the diet is easy to be stagnated, and the striga asiatica and the stir-fried rice sprouts are added to promote digestion and remove food retention; the charcoal, the residue distribution and leaves, belong to the good products in the south of the Ling, have the functions of promoting diuresis and removing food retention, and conform to the characteristics of spleen preference for dryness and damp-repellent. According to the theory that qi is the general of blood and blood is the mother of qi, danshen is added to promote qi and activate blood circulation to relieve depression. The medicines are combined, and the medicine is suitable for movement and static, can be supplemented without stagnation, is warm without dryness, and has the effects of resolving depression and tranquillizing, strengthening spleen and tonifying qi, and relieving stuffiness and fullness.
The traditional Chinese medicine used in the invention has the following properties:
vinegar bupleurum root: pungent and bitter in flavor and slightly cold in nature; it enters liver, gallbladder and lung meridians. Has effects of relieving exterior syndrome, dispersing stagnated liver qi, relieving qi stagnation, invigorating yang, relieving heat, and preventing malaria. Is mainly used for treating common cold with fever, cold and heat, chest and hypochondrium distending pain, irregular menstruation, uterine prolapse and rectocele. Modern pharmacological researches show that vinegar processed bupleurum root can increase bile secretion, has better fatty liver and transaminase resisting effect, and has obvious protective effect on experimental liver injury.
White peony root: bitter and sour in taste and slightly cold in nature; enter liver and spleen meridians. Has effects of nourishing blood, regulating menstruation, astringing yin, suppressing sweating, softening liver, relieving pain, and suppressing liver yang. Is mainly used for treating blood deficiency and sallow complexion, irregular menstruation, spontaneous perspiration, night sweat, hypochondriac pain, abdominal pain, limb contracture pain, headache and dizziness. Modern pharmacological researches have shown that white peony root has the effects of protecting liver, promoting hematopoiesis, resisting liver injury, tranquilizing, resisting depression, regulating gastrointestinal function, resisting ischemia and inflammation, etc.
Jasmine flower: bitter taste and neutral nature; enter liver meridian. Has effects of dispersing stagnated liver qi for relieving qi stagnation, activating qi-flowing and relieving pain. Is mainly used for treating hypochondriac pain, epigastric pain and diarrhea and abdominal pain caused by liver depression and qi stagnation. Modern pharmacological studies show that jasmine flower has spasmolytic and antitumor effects.
Radix Curcumae: pungent and bitter in flavor and cold in nature; it enters liver, heart and lung meridians. Has effects of promoting blood circulation, relieving pain, activating qi-flowing, resolving stagnation, clearing heart fire, cooling blood, promoting bile flow, and eliminating jaundice. Is mainly used for treating amenorrhea dysmenorrhea, chest and abdominal distention and pain, stinging pain, fever, coma, epilepsy, and jaundice and dark urine. Modern pharmacological researches have shown that radix Curcumae has the effects of immunosuppression, antiallergic, liver protecting, gallbladder function promoting, gastric acid inhibiting, lipid metabolism promoting, plaque formation in artery intima inhibiting, anticoagulant and platelet aggregation inhibiting, analgesic and sleep promoting.
Radix pseudostellariae: sweet and slightly bitter in taste and mild in nature; enter spleen and lung meridians. Has effects of invigorating qi and spleen, promoting salivation, and moistening lung. Is mainly used for treating spleen deficiency, tiredness, inappetence, weakness after illness, deficiency of qi and yin, spontaneous perspiration, thirst, and dry cough. Modern pharmacological researches have shown that radix Pseudostellariae has effects of enhancing immunity, improving memory, resisting stress, relieving fatigue, improving small intestine absorption capacity, lowering blood sugar, reducing blood lipid, resisting bacteria, relieving cough, resisting virus, eliminating phlegm, and relieving inflammation.
Ficus simplicissima lour: slightly warm in nature and sweet in taste; it enters lung, spleen, stomach, large intestine and liver meridians. Has effects of invigorating qi, invigorating spleen, eliminating phlegm, relieving asthma, activating qi-flowing, eliminating dampness, relieving rigidity of muscles, and activating collaterals. Is mainly used for treating cough due to lung deficiency and phlegm, tiredness and weakness of limbs due to spleen and stomach deficiency, anorexia and abdominal distention, spleen deficiency edema, leukorrhagia, rheumatalgia, lumbago and skelalgia, etc. Modern pharmacological researches have shown that Ficus simplicissima lour has protective effects on gastrointestinal tract and liver, and has effects of enhancing immunity, and resisting oxidation, radiation and aging.
Poria with pine needle: sweet in taste and neutral in nature; it enters heart and spleen meridians. Has effects of tranquilizing mind, inducing diuresis to alleviate edema, invigorating spleen and regulating stomach. Is mainly used for treating palpitation due to deficiency of heart, amnesia, insomnia, convulsion, and dysuria. Modern pharmacological studies show that Poria has an improving effect on gastrointestinal dyspepsia.
Cortex Albiziae: sweet in taste and neutral in nature; it enters heart, liver and lung meridians. Has effects of resolving stagnation, tranquilizing, promoting blood circulation, and relieving swelling. Is mainly used for treating uneasiness, depression, insomnia, lung abscess, sore, swelling and traumatic injury. Modern pharmacological researches have shown that cortex Albiziae has sedative, antidepressant, immunostimulant and antitumor effects.
Pummelo peel: pungent and bitter in taste and warm in nature; enter lung and spleen meridians. Has effects of regulating qi-flowing, relieving cough, invigorating spleen, and resolving food stagnation. Is mainly used for treating phlegm stagnation in chest, cough, asthma, vomiting and hiccup, and food stagnation. Modern pharmacological researches have shown that exocarpium Citri Grandis has the effects of promoting gastric secretion, relieving inflammation, relieving cough and eliminating phlegm.
Chicken bone fragrance: slightly bitter and pungent in taste and warm in nature; it enters heart, lung, liver, stomach and kidney meridians. Has effects of regulating qi-flowing, relieving pain, dispelling pathogenic wind, removing dampness, and relieving swelling and pain. Is mainly used for treating abdominal distending pain, rheumatalgia, hernia pain, dysmenorrhea, sore throat, traumatic injury and swelling and pain, etc. Modern pharmacological studies show that the chicken bone has remarkable physiological activities of resisting tumor, inflammation, pain, bacteria and the like.
Sandalwood: pungent taste and warm nature; it enters spleen, stomach, heart and lung meridians. Has effects in activating qi-flowing, warming spleen and stomach, stimulating appetite, and relieving pain. Is mainly used for treating cold congealing and qi stagnation, chest pain, abdominal pain and stomach ache with little food; coronary heart disease and angina pectoris. Modern pharmacological studies show that sandalwood has the functions of enhancing gastrointestinal motility and promoting secretion of digestive juice.
Fructus Akebiae: sweet in taste and cold in nature; enter liver, stomach and bladder meridians. Has effects of dispersing stagnated liver qi, regulating stomach function, promoting blood circulation, relieving pain, softening and resolving hard mass, and promoting urination. Is mainly used for treating liver and stomach qi stagnation, abdominal pain, hypochondriac pain, diarrhea, hernia pain, lumbago, amenorrhea and dysmenorrhea. Modern pharmacological researches show that akebia fruit has the effects of resisting bacteria, diminishing inflammation and protecting liver, and has good effects of treating hepatitis and gastric ulcer.
Fructus Amomi: pungent taste and warm nature; it enters spleen, stomach and kidney meridians. Has effects of eliminating dampness, stimulating appetite, warming spleen, relieving diarrhea, regulating qi-flowing, and preventing miscarriage. Is mainly used for treating damp turbidity obstruction, gastric fullness and hunger, spleen and stomach deficiency cold, vomiting and diarrhea, vomiting of pregnancy and lochia and fetal movement. Modern pharmacological studies show that fructus Amomi has effects of regulating gastrointestinal function, anti-inflammatory and analgesic.
Fructus Amomi rotundus: pungent taste and warm nature; enter lung, spleen and stomach meridians. Has effects of eliminating dampness, relieving distention, activating qi-flowing, warming spleen and stomach, stimulating appetite, and resolving food stagnation. Is mainly used for treating damp obstruction in middle energizer, anorexia, early stage of damp-warm syndrome, chest distress and hunger, cold-damp vomiting, chest and abdominal distention and pain, and indigestion. Modern pharmacological studies show that cardamom can promote gastric secretion, excite intestinal peristalsis, expel intestinal qi, inhibit abnormal fermentation in intestines, and has good stomach strengthening and vomiting stopping effects.
Perilla stem: pungent taste and warm nature; enter lung and spleen meridians. Has effects of regulating qi-flowing, relieving pain, and preventing miscarriage. Is mainly used for treating chest and diaphragm stuffiness, epigastric pain, belch, vomiting and fetal irritability. Modern pharmacological studies have shown that perilla stem promotes gastrointestinal smooth muscle movement.
The pericarpium Arecae: pungent taste and slightly warm nature; enter spleen, stomach, large intestine and small intestine meridians. Has effects in promoting qi circulation, regulating middle warmer, and inducing diuresis to alleviate edema. Is mainly used for treating damp obstruction and qi stagnation, abdominal distention and fullness, difficult urination, edema and edema of beriberi and difficult urination. Modern pharmacological studies show that the large abdominal skin mainly acts on the contraction of large intestine smooth muscle, can raise the tension of intestinal canal and promote gastrointestinal motility.
Reed rhizome: sweet in taste and cold in nature; enter lung and stomach meridians. Has effects of clearing heat, promoting salivation, relieving restlessness, relieving vomit, and promoting urination. It is used for treating pyretic polydipsia, vomiting due to stomach heat, cough due to lung heat, pulmonary abscess with pus, and stranguria due to heat. Modern pharmacological studies show that reed rhizome has antipyretic, sedative, analgesic, antihypertensive, hypoglycemic, antioxidant and estrogen-like effects and has inhibition effect on beta-hemolytic streptococcus.
Bamboo shavings: sweet in taste and slightly cold in nature; enter lung and stomach meridians. Has effects of clearing heat, eliminating phlegm, removing vexation and relieving vomiting. Is mainly used for treating cough due to phlegm heat, phlegm with gallbladder fire, dysphoria with smothery sensation, emesis due to stomach heat, pernicious vomiting, fetal irritability, etc. Modern pharmacological researches have shown that the caulis Bambusae in Taenia has the pharmacological effects of reducing blood lipid, relieving fatigue, regulating digestive function, promoting bile flow and promoting urination.
Radix et rhizoma Lepidii: sweet and light in taste and cool in nature; it enters kidney meridian, spleen meridian and liver meridian. Has effects of suppressing hyperactive liver, resolving malnutrition, invigorating spleen, resolving food stagnation, clearing heat and promoting urination. Is used for treating infantile malnutrition, infantile summer heat, infantile diarrhea, and icteric hepatitis. Modern pharmacological studies show that striga asiatica can improve digestive function, promote appetite and regulate intestinal flora balance.
Parching rice sprout: sweet taste and warm nature; enter spleen and stomach meridians. Has effects of regulating stomach, resolving food stagnation, invigorating spleen and stimulating appetite. Is mainly used for treating indigestion, abdominal distention, halitosis, spleen and stomach weakness, hunger and anorexia. Modern pharmacological researches have shown that the fried rice sprouts have the effects of promoting digestion, reducing blood sugar, resisting fungi and the like.
Charcoal mother: slightly sour and slightly astringent, cool in nature; enter liver meridian and spleen meridian. Has effects of clearing heat and detoxicating, promoting diuresis, removing food stagnation, cooling blood, relieving itching, improving eyesight, and removing nebula. Is mainly used for treating diarrhea, enteritis, dyspepsia, hepatitis, cold, etc. Modern pharmacological researches show that the Chinese knotweed has the functions of resisting inflammation, relieving pain, resisting oxidation, resisting hepatitis B virus, resisting bacteria, resisting diarrhea and the like.
Slag distribution leaves: slightly sour taste and cool nature; enter spleen and stomach meridians. Has effects of resolving food stagnation, clearing heat and promoting diuresis. It is mainly used for treating food stagnation, common cold, fever, damp-heat jaundice. Modern pharmacological researches have shown that the leaves have the functions of resisting oxidation, reducing blood fat, relieving pain, resisting inflammation, protecting cardiovascular system, relieving fever, etc.
Root of red-rooted salvia: bitter taste and slightly cold nature; it enters heart and liver meridians. Has effects of promoting blood circulation, removing blood stasis, dredging channels, relieving pain, clearing heart fire, relieving restlessness, cooling blood, and resolving carbuncle. Is used for treating chest pain, pain in the abdomen and hypochondrium, abdominal mass, pain due to pyretic arthralgia, vexation, insomnia, menoxenia, dysmenorrhea, amenorrhea, and pyocutaneous disease. Modern pharmacological studies show that the salvia miltiorrhiza has the effects of protecting cardiac muscle, dilating blood vessels, resisting atherosclerosis, resisting thrombosis and the like.
Preferably, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 5-10 parts of vinegar radix bupleuri, 9-15 parts of white peony root, 6-10 parts of jasmine flower, 6-12 parts of radix curcumae, 10-30 parts of radix pseudostellariae, 20-30 parts of five-finger wild peach, 9-12 parts of poria with hostwood, 6-12 parts of cortex albiziae, 4-6 parts of pummelo peel, 9-15 parts of chicken bone, 3-5 parts of sandalwood, 9-12 parts of fiveleaf akebia fruit, 4-6 parts of fructus amomi, 4-6 parts of cardamom, 6-10 parts of perilla stem, 6-10 parts of pericarpium arecae, 15-20 parts of reed rhizome, 6-10 parts of bamboo shavings, 6-25 parts of striga, 9-12 parts of stir-fried rice sprout, 9-12 parts of herb of Chinese knotweed, 15-25 parts of folium mori and 6-12 parts of radix salviae miltiorrhizae.
More preferably, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 6-10 parts of vinegar radix bupleuri, 12-15 parts of white peony root, 6-9 parts of jasmine flower, 6-9 parts of radix curcumae, 10-20 parts of radix pseudostellariae, 25-30 parts of five-finger wild peach, 9-10 parts of poria with hostwood, 6-10 parts of cortex albiziae, 4-5 parts of pummelo peel, 10-15 parts of chicken bone, 3-4 parts of sandalwood, 9-10 parts of fiveleaf akebia fruit, 5-6 parts of fructus amomi, 5-6 parts of cardamom, 6-9 parts of perilla stem, 9-10 parts of pericarpium arecae, 15-20 parts of reed rhizome, 9-10 parts of bamboo shavings, 6-15 parts of striga, 9-10 parts of stir-fried rice sprout, 9-10 parts of herb of Chinese knotweed, 15-20 parts of folium mori and 6-10 parts of radix salviae miltiorrhizae.
Specifically, the traditional Chinese medicine composition comprises the following raw material medicines in parts by weight: 9 parts of vinegar radix bupleuri, 15 parts of white peony root, 6 parts of jasmine flower, 6 parts of radix curcumae, 15 parts of radix pseudostellariae, 30 parts of five-finger wild peach, 10 parts of poria with hostwood, 9 parts of cortex albiziae, 5 parts of pummelo peel, 12 parts of chicken bone, 3 parts of sandalwood, 10 parts of fiveleaf akebia fruit, 6 parts of fructus amomi, 6 parts of cardamom, 6 parts of perilla stem, 10 parts of areca peel, 15 parts of reed rhizome, 9 parts of caulis bambusae in taenian, 10 parts of striga asiatica, 10 parts of stir-fried rice sprout, 10 parts of charcoal, 20 parts of cloth residue leaf and 10 parts of radix salviae miltiorrhizae.
The invention also provides a traditional Chinese medicine oral preparation, which comprises the traditional Chinese medicine composition.
Further, the oral preparation is decoction, granule, capsule, tablet, pill or oral liquid.
Meanwhile, the invention protects the application of the traditional Chinese medicine composition in preparing a medicine for treating liver depression and spleen deficiency type distention and fullness.
Preferably, the liver depression and spleen deficiency type distention and fullness are chronic gastritis, and treat functional dyspepsia and gastrointestinal neurosis.
The invention has the following beneficial effects:
the traditional Chinese medicine composition comprises vinegar bupleurum, white peony root, jasmine flower, radix curcumae, radix pseudostellariae, five-finger wild peach, poria with hostwood, cortex albiziae, exocarpium citri rubrum, chicken bone fragrance, sandalwood, fiveleaf akebia fruit, fructus amomi, cardamom, perilla stem, pericarpium arecae, reed rhizome, bamboo shavings, radix et rhizoma typhae, stir-fried rice sprouts, charcoal, residue leaves and radix salviae miltiorrhizae, accords with the compatibility principle of monarch, minister, assistant and guide in traditional Chinese medicine, and the components supplement each other, and has the effects of resolving depression and tranquillizing, strengthening spleen and tonifying qi, and relieving distension and fullness. Clinical experiments show that the traditional Chinese medicine composition has good treatment effect on chronic gastritis, functional dyspepsia and gastrointestinal neurosis which belong to liver depression and spleen deficiency syndrome differentiation, the total effective rate is more than 93%, no adverse reaction is caused, and the traditional Chinese medicine composition is suitable for popularization and application. Meanwhile, the traditional Chinese medicine composition adopts more common Chinese herbal medicines on the market as raw materials, and has the advantages of low cost and easy preparation.
Detailed Description
The present invention is further illustrated below with reference to specific examples, which are not intended to limit the invention in any way. Unless specifically stated otherwise, the reagents, methods and apparatus employed in the present invention are those conventional in the art.
Reagents and materials used in the following examples are commercially available unless otherwise specified.
Example 1A Chinese medicinal decoction for the treatment of distention and fullness
The formula of the traditional Chinese medicine composition comprises the following steps: 9g of vinegar radix bupleuri, 15g of white peony root, 6g of jasmine flower, 6g of radix curcumae, 15g of radix pseudostellariae, 30g of five-finger wild peach, 10g of poria with hostwood, 9g of cortex albiziae, 5g of pummelo peel, 12g of chicken bone, 3g of sandalwood, 10g of fiveleaf akebia fruit, 6g of fructus amomi, 6g of cardamom, 6g of perilla stem, 10g of pericarpium arecae, 15g of reed rhizome, 9g of caulis bambusae in taenian, 15g of striga asiatica, 10g of fried rice sprout, 10g of charcoal, 20g of cloth residue leaf and 10g of radix salviae miltiorrhizae.
The preparation method of the decoction comprises the following steps: soaking a dose of Chinese medicine in 1000mL of water for about 30 minutes, firstly decocting with strong fire to a boiling state, then keeping the liquid medicine slightly boiling state with slow fire, decocting for about 25 minutes, filtering to remove residues, and obtaining the decocted liquid medicine which is the required Chinese medicine. One dose is decocted for 2 times, and 400-600 mL of liquid medicine is obtained by decoction, thus obtaining the liquid medicine with one daily dose.
Example 2A Chinese medicinal decoction for the treatment of distention and fullness
The formula of the traditional Chinese medicine composition comprises the following steps: 10g of vinegar radix bupleuri, 12g of white peony root, 5g of jasmine flower, 12g of radix curcumae, 15g of radix pseudostellariae, 25g of five-finger wild peach, 9g of poria with hostwood, 9g of cortex albiziae, 5g of pummelo peel, 10g of chicken bone, 3g of sandalwood, 9g of fiveleaf akebia fruit, 6g of fructus amomi, 6g of cardamom, 6g of perilla stem, 6g of pericarpium arecae, 20g of reed rhizome, 10g of caulis bambusae in taenian, 15g of striga asiatica, 10g of fried rice sprout, 9g of charcoal, 20g of cloth residue leaf and 12g of radix salviae miltiorrhizae.
The preparation method of the decoction comprises the following steps: consistent with example 1.
Example 3A Chinese medicinal decoction for the treatment of distention and fullness
The formula of the traditional Chinese medicine composition comprises the following steps: 10g of vinegar radix bupleuri, 15g of white peony root, 6g of jasmine flower, 6g of radix curcumae, 15g of radix pseudostellariae, 20g of five-finger wild peach, 15g of poria with hostwood, 10g of cortex albiziae, 6g of pummelo peel, 10g of chicken bone, 3g of sandalwood, 9g of fiveleaf akebia fruit, 6g of fructus amomi, 6g of cardamom, 6g of perilla stem, 10g of pericarpium arecae, 25g of reed rhizome, 10g of caulis bambusae in taenian, 25g of striga asiatica, 15g of fried rice sprout, 9g of charcoal, 25g of cloth residue leaf and 6g of radix salviae miltiorrhizae.
The preparation method of the decoction comprises the following steps: consistent with example 1.
Example 4A Chinese medicinal granule for treating distention and fullness
The traditional Chinese medicine composition comprises the following components in parts by weight: 9 parts of vinegar radix bupleuri, 15 parts of white peony root, 6 parts of jasmine flower, 6 parts of radix curcumae, 15 parts of radix pseudostellariae, 30 parts of five-finger wild peach, 10 parts of poria with hostwood, 9 parts of cortex albiziae, 5 parts of pummelo peel, 12 parts of chicken bone, 3 parts of sandalwood, 10 parts of fiveleaf akebia fruit, 6 parts of fructus amomi, 6 parts of cardamom, 6 parts of perilla stem, 10 parts of areca peel, 15 parts of reed rhizome, 9 parts of caulis bambusae in taenian, 10 parts of striga asiatica, 10 parts of stir-fried rice sprout, 10 parts of charcoal, 20 parts of cloth residue leaf and 10 parts of radix salviae miltiorrhizae.
The preparation method of the granule comprises the following steps:
s1, preparing vinegar radix bupleuri, radix paeoniae alba, jasmine flower, radix curcumae, radix pseudostellariae, five-finger wild peach, poria with hostwood, cortex albiziae, exocarpium citri rubrum, chicken bone fragrance, sandalwood, fiveleaf akebia fruit, fructus amomi, cardamom, perilla stem, pericarpium arecae, reed rhizome, caulis bambusae in taenia, striga asiatica, stir-fried rice sprout, herb of Chinese knotweed, leaf of cloth residue and radix salviae miltiorrhizae according to the weight part of the formula, cleaning, putting into a multifunctional extraction tank, adding water for 2 times, boiling for 2 hours for the first time, boiling for 1.5 hours for the second time, merging the decoctions, filtering, concentrating the filtrate, adding alcohol to enable the alcohol content to reach 50%, stirring uniformly, standing for 24 hours at 2-6 ℃, filtering, recovering ethanol from the filtrate, concentrating, timely performing paste collecting treatment, drying under reduced pressure, crushing, sieving with 80-mesh sieve, and uniformly mixing to obtain dry extract powder;
s2, uniformly mixing the dry extract powder, the dextrin and the sucrose powder according to the proportion of 1:0.5:1, wetting and granulating by using a proper amount of ethanol, drying at the temperature below 80 ℃, finishing the granules, sterilizing, and packaging into bags to obtain the granules.
Example 5A Chinese medicinal composition in the form of capsule for treating distention and fullness
The traditional Chinese medicine composition comprises the following components in parts by weight: consistent with example 4.
The preparation method of the capsule comprises the following steps:
s1, according to the embodiment 4;
s2, uniformly mixing the dry extract powder, the dextrin and the sucrose powder according to the proportion of 1:0.5:1, wetting and granulating by using a proper amount of ethanol, drying at the temperature below 80 ℃, finishing the granules, encapsulating, sterilizing and packaging to obtain the capsule.
Example 6A Chinese medicinal composition tablet for treating distention and fullness
The traditional Chinese medicine composition comprises the following components in parts by weight: consistent with example 4.
The preparation method of the tablet traditional Chinese medicine composition comprises the following steps:
s1, according to the embodiment 4;
s2, uniformly mixing the dry extract powder, the dextrin and the sucrose powder according to the proportion of 1:0.5:1, wetting and granulating by using a proper amount of ethanol, drying at the temperature below 80 ℃, granulating, tabletting, sterilizing and packaging to obtain the tablet.
Example 7A Chinese medicinal composition pill for treating distention and fullness
The traditional Chinese medicine composition comprises the following components in parts by weight: consistent with example 4.
The preparation method of the traditional Chinese medicine composition comprises the following steps: according to the weight portions of the formula, vinegar-processed bupleurum, white peony root, jasmine flower, curcuma aromatica, radix pseudostellariae, five-finger wild peach, poria with hostwood, cortex albiziae, exocarpium citri rubrum, chicken bone fragrance, sandalwood, fiveleaf akebia fruit, fructus amomi, cardamom, perilla stem, pericarpium arecae, reed rhizome, bamboo shavings, striga asiatica, stir-fried rice sprouts, charcoal, cloth residue leaves and radix salviae miltiorrhizae are prepared, washed, dried, crushed and screened to obtain powder for standby. Adding water and refined honey into the powder, stirring the powder, the refined honey and the water according to the mass ratio of 10:3:30, adding the mixture into a mould after the mixture is uniform in mass, preparing the pill-type traditional Chinese medicine composition with the particle size of 3-6 mm, sterilizing and packaging the pill-type traditional Chinese medicine composition to obtain the pill.
Example 8A Chinese medicinal oral liquid for treating distention and fullness
The traditional Chinese medicine composition comprises the following components in parts by weight: consistent with example 4.
The preparation method of the traditional Chinese medicine composition oral liquid comprises the following steps: according to the weight portions of the formula, preparing vinegar bupleurum, white peony root, jasminum grandiflorum, curcuma aromatica, radix pseudostellariae, figwort, poria with hostwood, cortex albiziae, pummelo peel, chicken bone, sandalwood, fiveleaf akebia fruit, fructus amomi, cardamom, perilla stem, pericarpium arecae, reed rhizome, bamboo shavings, radix stephaniae tetrandrae, stir-fried rice sprouts, charcoal, cotton residue leaves and radix salviae miltiorrhizae, cleaning, putting into a multifunctional extraction tank, adding water for decocting for 2 times, decocting for 2 hours for the first time, decocting for 1.5 hours for the second time, merging decoctions, filtering, concentrating the filtrate, adding alcohol to enable the alcohol content to reach 75%, stirring, standing for 24 hours at 2-6 ℃, filtering, recovering ethanol from the filtrate, concentrating under reduced pressure to thick paste, adding a proper amount of single syrup and sodium benzoate, diluting with water, mixing, cooling, filtering again, filling and sterilizing, and packaging to obtain the oral liquid preparation.
Comparative example 1
The formula comprises the following components: the only difference from example 1 is that vinegar radix bupleuri was replaced with raw radix bupleuri and white peony root was replaced with red peony root.
The preparation method comprises the following steps: consistent with example 1.
Comparative example 2
The formula comprises the following components: the only difference from example 1 is that the radix pseudostellariae, the hispid fig components were omitted.
The preparation method comprises the following steps: consistent with example 1.
The invention is suitable for: the syndrome differentiation is based on liver depression and spleen deficiency type chronic gastritis, functional dyspepsia and gastrointestinal neurosis.
The pregnant woman is forbidden to take.
Clinical verification: the Chinese medicinal decoction for treating the distention and fullness prepared in the embodiment 1 and the comparative examples 1 and 2 is used for clinical research schemes, and further verifies the beneficial effects of the invention.
Test example 1 Chinese medicinal composition for treating chronic gastritis
1. Clinical subjects: 128 cases of chronic gastritis patients with liver depression and spleen deficiency are taken as the study object and divided into 32 cases of control group, example 1 group, comparative example 1 group and comparative example 2 group according to a random number table method. The differences of the age, sex, course of disease and the like of each group are not significant.
The control group was treated with western medicine: esomeprazole magnesium enteric-coated tablets are orally taken before meals, 20mg each time, 2 times a day; amoxicillin dispersible tablet is orally taken after meal, 1g each time, 2 times each day; the clarithromycin slow release capsule is orally taken after meal, and is 0.5g each time and 2 times a day; bismuth potassium citrate capsule, orally taken after meal, 0.6g each time, 2 times daily. The other three groups are respectively treated by the pharmaceutical components of the example 1, the comparative example 1 and the comparative example 2 (the traditional Chinese medicines are decocted, taken orally, and taken orally once a day, and warm taken for 2 times a day and a night, and about 200-300 mL are taken each time). Each group had 1 course of treatment for 2 weeks for a total of 1 course of treatment.
2. Diagnostic criteria:
western diagnostic criteria: reference is made to the diagnosis standard of "Chinese chronic gastritis consensus opinion" and "endoscopic classification grading Standard and treatment trial opinion" of chronic gastritis.
Diagnostic criteria for traditional Chinese medicine: reference is made to the diagnosis standard of "the consensus of chronic gastritis traditional Chinese medicine and diagnosis specialist (2017)".
3. Efficacy assessment criteria:
the clinical syndrome curative effect evaluation table of the chronic gastritis patient is formulated by referring to the traditional Chinese medicine new medicine clinical research guidelines, the total sum of clinical symptoms and physical sign scores of the patient is counted according to the clinical syndrome curative effect evaluation table, the curative effect is evaluated according to the following formula, and the calculation formula is as follows:
efficacy index = [ (pre-treatment integral-post-treatment integral)/pre-treatment integral ] ×100%
Efficacy assessment: (1) clinical recovery: the clinical symptoms and signs of the traditional Chinese medicine disappear or disappear basically, and the curative effect index is more than or equal to 95%; (2) obvious effect: the clinical symptoms and physical signs of the traditional Chinese medicine are obviously improved, and the curative effect index is more than or equal to 70% and less than 95%; (3) effective: the clinical symptoms and physical signs of the traditional Chinese medicine are improved, and the curative effect index is less than 70% and is more than or equal to 30%; (4) ineffective: the clinical symptoms and physical signs of the traditional Chinese medicine are not obviously improved or even aggravated, and the curative effect index is less than 30 percent.
Total efficacy (total effective rate) = (total number of cases-number of ineffective cases)/total number of cases×100%.
4. Therapeutic results
After the treatment course is over, 10 cases are cured in the group of the example 1, 16 cases are effective, 4 cases are effective, 2 cases are ineffective, and the total effective rate is 93.75%; in the group 1 of the comparative example, 5 cases are cured, 12 cases are obvious, 10 cases are effective, 5 cases are ineffective, and the total effective rate is 84.38%; 3 cases are cured in the group of comparative example 2, 8 cases are obvious, 14 cases are effective, 7 cases are ineffective, and the total effective rate is 78.13%; in the control group, 1 case is cured, 3 cases are effectively treated, 19 cases are effectively treated, 9 cases are not effectively treated, the total effective rate is 71.88%, and patients treated by the traditional Chinese medicine composition have no adverse reaction after the treatment course is over. The results show that the total effective rate of the group of the example 1 is higher than that of other groups after treatment, and the traditional Chinese medicine preparation prepared by adopting the raw materials and the preparation method has good effect of treating liver depression and spleen deficiency type chronic gastritis, and the drug effect of the traditional Chinese medicine preparation is influenced by the change of the drug in the comparative example 1; the traditional Chinese medicine preparation of comparative example 2 has reduced efficacy due to omission of the radix pseudostellariae and the five-finger nectarine components.
Test example 2 therapeutic Effect of Chinese medicinal composition on functional dyspepsia
1. Clinical subjects: 172 patients with liver depression and spleen deficiency type functional dyspepsia are divided into a control group, an example 1 group, a comparative example 1 group and a comparative example 2 group according to a random number table method, and 43 patients are respectively served as the study subjects. The differences of the age, sex, course of disease and the like of each group are not significant.
The control group was treated with western medicine: domperidone tablet is orally taken 30min before meal, 10mg each time, 3 times daily. The other three groups are respectively treated by the pharmaceutical components of the example 1, the comparative example 1 and the comparative example 2 (the traditional Chinese medicines are decocted, taken orally, and taken orally once a day, and warm taken for 2 times a day and a night, and about 200-300 mL are taken each time). Each group had 1 course of treatment for 4 weeks for a total of 1 course of treatment.
2. Diagnostic criteria:
western diagnostic criteria: reference is made to the diagnostic criteria of the Chinese functional dyspepsia expert consensus (2015, shanghai) and Roman IV.
Diagnostic criteria for traditional Chinese medicine: reference is made to the diagnostic criteria of the "functional dyspepsia chinese medical science medical expert consensus opinion (2017)".
3. Efficacy assessment criteria:
the clinical syndrome curative effect evaluation table of the functional dyspepsia patients of the test example is formulated by referring to the "Chinese medicine New medicine clinical research guidelines", the sum of clinical symptoms and physical sign scores of the patients is counted according to the clinical syndrome curative effect evaluation table, the curative effect is evaluated according to the following formula, and the calculation formula is as follows:
efficacy index (total efficacy) = [ (pre-treatment integral-post-treatment integral)/pre-treatment integral ] ×100%
Efficacy assessment: (1) clinical recovery: the clinical symptoms and signs of the traditional Chinese medicine disappear or disappear basically, and the curative effect index is more than or equal to 95%; (2) obvious effect: the clinical symptoms and physical signs of the traditional Chinese medicine are obviously improved, and the curative effect index is more than or equal to 70% and less than 95%; (3) effective: the clinical symptoms and physical signs of the traditional Chinese medicine are improved, and the curative effect index is less than 70% and is more than or equal to 30%; (4) ineffective: the clinical symptoms and physical signs of the traditional Chinese medicine are not obviously improved or even aggravated, and the curative effect index is less than 30 percent.
Total efficacy (total effective rate) = (total number of cases-number of ineffective cases)/total number of cases×100%.
4. Treatment results:
after the treatment course is over, 20 cases are cured in the group of the example 1, 17 cases are effective, 3 cases are ineffective, and the total effective rate is 93.02%; in the group of comparative example 1, 13 cases are cured, 9 cases are effective, 14 cases are effective, 7 cases are ineffective, and the total effective rate is 83.72%; 6 cases are cured in the group of comparative example 2, 7 cases are obvious, 21 cases are effective, 9 cases are ineffective, and the total effective rate is 79.07%; in the control group, 2 cases are cured, 4 cases are effective, 27 cases are effective, 10 cases are ineffective, the total effective rate is 76.74%, and patients treated by the traditional Chinese medicine composition have no adverse reaction after the treatment course is over. The results show that the total effective rate of the group of the example 1 is higher than that of other groups after treatment, and the traditional Chinese medicine preparation prepared by adopting the raw materials and the preparation method has good effect of treating liver depression and spleen deficiency type functional dyspepsia, and the drug effect of the traditional Chinese medicine preparation of the comparative example 1 is influenced by the change of drugs; the traditional Chinese medicine preparation of comparative example 2 has reduced efficacy due to omission of the radix pseudostellariae and the five-finger nectarine components.
Test example 3 therapeutic Effect of compositions on gastrointestinal neurosis
1. Clinical subjects: 156 patients with liver depression and spleen deficiency type gastrointestinal neurosis are taken as the study objects and divided into a control group, an example 1 group, a comparative example 1 group and a comparative example 2 group according to a random number table method, and 39 patients are respectively. The differences of the age, sex, course of disease and the like of each group are not significant.
The control group is treated by conventional Western medicine, and psychological dispersion treatment is properly carried out on the patients with serious anxiety and depression, and the administration scheme is as follows: (1) Domperidone tablets are orally taken for 30min before meals for patients with dyspepsia, 10mg each time, 3 times daily; omeprazole enteric-coated capsules are treated, orally taken before meals, 20mg each time, 2 times a day. (2) The bifidobacterium triple viable bacteria capsule is orally taken for patients with irritable bowel syndrome after meals, 420mg of the capsule is taken for each time, and the severe symptoms can be doubled for taking the capsule 3 times a day. The other three groups are respectively treated by the pharmaceutical components of the example 1, the comparative example 1 and the comparative example 2 (the traditional Chinese medicines are decocted, taken orally, and taken orally once a day, and warm taken for 2 times a day and a night, and about 200-300 mL are taken each time). Each group had 1 course of treatment for 4 weeks for a total of 1 course of treatment.
2. Diagnostic criteria:
western diagnostic criteria: reference is made to the diagnostic criteria of gastroenterology and Roman IV.
Diagnostic criteria for traditional Chinese medicine: reference is made to the diagnosis standard of the traditional Chinese medicine disease diagnosis curative effect standard.
3. Efficacy assessment criteria:
the clinical syndrome curative effect evaluation table of the patient with the gastrointestinal neurosis of the test example is formulated by referring to the 'traditional Chinese medicine new medicine clinical research guidelines', the sum of clinical symptoms and physical sign scores of the patient is counted according to the clinical syndrome curative effect evaluation table, the curative effect is evaluated according to the following formula, and the calculation formula is as follows:
efficacy index (total efficacy) = [ (pre-treatment integral-post-treatment integral)/pre-treatment integral ] ×100%
Efficacy assessment: (1) clinical recovery: the clinical symptoms and signs of the traditional Chinese medicine disappear or disappear basically, and the curative effect index is more than or equal to 95%; (2) obvious effect: the clinical symptoms and physical signs of the traditional Chinese medicine are obviously improved, and the curative effect index is more than or equal to 70% and less than 95%; (3) effective: the clinical symptoms and physical signs of the traditional Chinese medicine are improved, and the curative effect index is less than 70% and is more than or equal to 30%; (4) ineffective: the clinical symptoms and physical signs of the traditional Chinese medicine are not obviously improved or even aggravated, and the curative effect index is less than 30 percent.
Total efficacy (total effective rate) = (total number of cases-number of ineffective cases)/total number of cases×100%.
4. Treatment results:
after the treatment course is over, 10 cases are cured in the group of the example 1, 23 cases are effective, 4 cases are effective, 2 cases are ineffective, and the total effective rate is 94.87%; in the group 1 of the comparative example, 5 cases are cured, 14 cases are obvious, 13 cases are effective, 7 cases are ineffective, and the total effective rate is 82.05%; in the group 2 of the comparative example, 3 cases are cured, 8 cases are obvious, 19 cases are effective, 9 cases are ineffective, and the total effective rate is 76.92%; in the control group, 1 case is cured, 4 cases are effectively treated, 24 cases are effectively treated, 10 cases are not effectively treated, the total effective rate is 74.36%, and patients treated by the traditional Chinese medicine composition have no adverse reaction after the treatment course is over. The results show that the total effective rate of the group of the example 1 is higher than that of other groups after treatment, and the traditional Chinese medicine preparation prepared by adopting the raw materials and the preparation method has good effect of treating liver depression and spleen deficiency type gastrointestinal neurosis, and the drug effect of the traditional Chinese medicine preparation of the comparative example 1 is influenced by the change of drugs; the traditional Chinese medicine preparation of comparative example 2 has reduced efficacy due to omission of the radix pseudostellariae and the five-finger nectarine components.
The above examples are preferred embodiments of the present invention, but the embodiments of the present invention are not limited to the above examples, and any other changes, modifications, substitutions, combinations, and simplifications that do not depart from the spirit and principle of the present invention should be made in the equivalent manner, and the embodiments are included in the protection scope of the present invention.
Claims (10)
1. The traditional Chinese medicine composition for treating the distention and fullness is characterized by comprising the following raw materials in parts by weight: 3-10 parts of vinegar radix bupleuri, 6-15 parts of white peony root, 5-10 parts of jasmine flower, 5-12 parts of radix curcumae, 9-30 parts of radix pseudostellariae, 15-30 parts of five-finger wild peach, 9-15 parts of poria with hostwood, 6-15 parts of cortex albiziae, 3-6 parts of pummelo peel, 6-15 parts of chicken bone, 2-5 parts of sandalwood, 9-15 parts of fiveleaf akebia fruit, 3-6 parts of fructus amomi, 3-6 parts of cardamom, 5-10 parts of perilla stem, 5-10 parts of pericarpium arecae, 15-30 parts of reed rhizome, 5-10 parts of bamboo shavings, 5-25 parts of striga, 9-15 parts of stir-fried rice sprout, 9-15 parts of herb of Chinese knotweed, 15-30 parts of folium mori and 6-15 parts of radix salviae miltiorrhizae.
2. The traditional Chinese medicine composition according to claim 1, wherein the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 5-10 parts of vinegar radix bupleuri, 9-15 parts of white peony root, 6-10 parts of jasmine flower, 6-12 parts of radix curcumae, 10-30 parts of radix pseudostellariae, 20-30 parts of five-finger wild peach, 9-12 parts of poria with hostwood, 6-12 parts of cortex albiziae, 4-6 parts of pummelo peel, 9-15 parts of chicken bone, 3-5 parts of sandalwood, 9-12 parts of fiveleaf akebia fruit, 4-6 parts of fructus amomi, 4-6 parts of cardamom, 6-10 parts of perilla stem, 6-10 parts of pericarpium arecae, 15-20 parts of reed rhizome, 6-10 parts of bamboo shavings, 6-25 parts of striga, 9-12 parts of stir-fried rice sprout, 9-12 parts of herb of Chinese knotweed, 15-25 parts of folium mori and 6-12 parts of radix salviae miltiorrhizae.
3. The traditional Chinese medicine composition according to claim 2, wherein the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 6-10 parts of vinegar radix bupleuri, 12-15 parts of white peony root, 6-9 parts of jasmine flower, 6-9 parts of radix curcumae, 10-20 parts of radix pseudostellariae, 25-30 parts of five-finger wild peach, 9-10 parts of poria with hostwood, 6-10 parts of cortex albiziae, 4-5 parts of pummelo peel, 10-15 parts of chicken bone, 3-4 parts of sandalwood, 9-10 parts of fiveleaf akebia fruit, 5-6 parts of fructus amomi, 5-6 parts of cardamom, 6-9 parts of perilla stem, 9-10 parts of pericarpium arecae, 15-20 parts of reed rhizome, 9-10 parts of bamboo shavings, 6-15 parts of striga, 9-10 parts of stir-fried rice sprout, 9-10 parts of herb of Chinese knotweed, 15-20 parts of folium mori and 6-10 parts of radix salviae miltiorrhizae.
4. The traditional Chinese medicine composition according to claim 3, wherein the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 9 parts of vinegar radix bupleuri, 15 parts of white peony root, 6 parts of jasmine flower, 6 parts of radix curcumae, 15 parts of radix pseudostellariae, 30 parts of five-finger wild peach, 10 parts of poria with hostwood, 9 parts of cortex albiziae, 5 parts of pummelo peel, 12 parts of chicken bone, 3 parts of sandalwood, 10 parts of fiveleaf akebia fruit, 6 parts of fructus amomi, 6 parts of cardamom, 6 parts of perilla stem, 10 parts of areca peel, 15 parts of reed rhizome, 9 parts of caulis bambusae in taenian, 10 parts of striga asiatica, 10 parts of stir-fried rice sprout, 10 parts of charcoal, 20 parts of cloth residue leaf and 10 parts of radix salviae miltiorrhizae.
5. An oral Chinese medicinal preparation for treating distention and fullness, which is characterized by comprising the Chinese medicinal composition according to any one of claims 1-4.
6. The oral formulation of claim 5, wherein the oral formulation is a decoction, a granule, a capsule, a tablet, a pill, or an oral liquid.
7. The use of the traditional Chinese medicine composition according to any one of claims 1 to 4 or the traditional Chinese medicine oral preparation according to claim 5 or 6 in preparing medicines for treating liver depression and spleen deficiency type distention and fullness.
8. The use according to claim 7, wherein said liver depression and spleen deficiency type of distention and fullness is chronic gastritis.
9. The use according to claim 7, wherein said liver depression and spleen deficiency type of fullness is functional dyspepsia.
10. The use according to claim 7, wherein said liver depression and spleen deficiency type of fullness and distention are gastrointestinal neurosis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311796591.3A CN117752758A (en) | 2023-12-25 | 2023-12-25 | Traditional Chinese medicine composition for treating distention and fullness and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202311796591.3A CN117752758A (en) | 2023-12-25 | 2023-12-25 | Traditional Chinese medicine composition for treating distention and fullness and application thereof |
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| CN202311796591.3A Pending CN117752758A (en) | 2023-12-25 | 2023-12-25 | Traditional Chinese medicine composition for treating distention and fullness and application thereof |
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| CN (1) | CN117752758A (en) |
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