CN117752543A - Mild foam antibacterial hand sanitizer and preparation method thereof - Google Patents
Mild foam antibacterial hand sanitizer and preparation method thereof Download PDFInfo
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- CN117752543A CN117752543A CN202311702099.5A CN202311702099A CN117752543A CN 117752543 A CN117752543 A CN 117752543A CN 202311702099 A CN202311702099 A CN 202311702099A CN 117752543 A CN117752543 A CN 117752543A
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- hand sanitizer
- antibacterial hand
- mild
- surface active
- active agent
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- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 68
- 239000006260 foam Substances 0.000 title claims abstract description 59
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 239000004094 surface-active agent Substances 0.000 claims abstract description 39
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 34
- 150000005846 sugar alcohols Polymers 0.000 claims abstract description 20
- 239000002738 chelating agent Substances 0.000 claims abstract description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 16
- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical compound CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000008213 purified water Substances 0.000 claims abstract description 11
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims abstract description 10
- -1 alkyl glycoside Chemical class 0.000 claims abstract description 10
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 10
- 230000003750 conditioning effect Effects 0.000 claims abstract description 10
- 229930182470 glycoside Natural products 0.000 claims abstract description 9
- YPFDHNVEDLHUCE-UHFFFAOYSA-N propane-1,3-diol Chemical compound OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 claims abstract description 9
- PXEDJBXQKAGXNJ-QTNFYWBSSA-L disodium L-glutamate Chemical compound [Na+].[Na+].[O-]C(=O)[C@@H](N)CCC([O-])=O PXEDJBXQKAGXNJ-QTNFYWBSSA-L 0.000 claims abstract description 8
- 229940015975 1,2-hexanediol Drugs 0.000 claims abstract description 7
- 229940079779 disodium cocoyl glutamate Drugs 0.000 claims abstract description 7
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims abstract description 7
- 238000002156 mixing Methods 0.000 claims abstract description 5
- 238000000034 method Methods 0.000 claims abstract description 4
- 239000000203 mixture Substances 0.000 claims description 29
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid group Chemical group C(CC(O)(C(=O)O)CC(=O)O)(=O)O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 15
- 238000003756 stirring Methods 0.000 claims description 15
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- 229940031723 1,2-octanediol Drugs 0.000 claims description 6
- JDRSMPFHFNXQRB-CMTNHCDUSA-N Decyl beta-D-threo-hexopyranoside Chemical compound CCCCCCCCCCO[C@@H]1O[C@H](CO)C(O)[C@H](O)C1O JDRSMPFHFNXQRB-CMTNHCDUSA-N 0.000 claims description 6
- 229940073499 decyl glucoside Drugs 0.000 claims description 6
- OEIJHBUUFURJLI-UHFFFAOYSA-N octane-1,8-diol Chemical compound OCCCCCCCCO OEIJHBUUFURJLI-UHFFFAOYSA-N 0.000 claims description 6
- HEGSGKPQLMEBJL-RKQHYHRCSA-N octyl beta-D-glucopyranoside Chemical compound CCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HEGSGKPQLMEBJL-RKQHYHRCSA-N 0.000 claims description 6
- DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 claims description 5
- 229940035437 1,3-propanediol Drugs 0.000 claims description 5
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims description 5
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 5
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- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims description 5
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical group [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 5
- 229960000458 allantoin Drugs 0.000 claims description 5
- 239000000022 bacteriostatic agent Substances 0.000 claims description 5
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical group OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 claims description 5
- 229960003333 chlorhexidine gluconate Drugs 0.000 claims description 5
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 5
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims description 5
- 229940113120 dipropylene glycol Drugs 0.000 claims description 5
- 238000010438 heat treatment Methods 0.000 claims description 5
- 229940101267 panthenol Drugs 0.000 claims description 5
- 235000020957 pantothenol Nutrition 0.000 claims description 5
- 239000011619 pantothenol Substances 0.000 claims description 5
- 229920000166 polytrimethylene carbonate Polymers 0.000 claims description 5
- 230000001105 regulatory effect Effects 0.000 claims description 5
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- 239000011732 tocopherol Substances 0.000 claims description 5
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims description 5
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims description 4
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims description 4
- 229940080421 coco glucoside Drugs 0.000 claims description 2
- PYIDGJJWBIBVIA-UYTYNIKBSA-N lauryl glucoside Chemical compound CCCCCCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O PYIDGJJWBIBVIA-UYTYNIKBSA-N 0.000 claims description 2
- 229940048848 lauryl glucoside Drugs 0.000 claims description 2
- 238000005187 foaming Methods 0.000 abstract description 6
- 230000007794 irritation Effects 0.000 abstract description 5
- 229920005862 polyol Polymers 0.000 abstract description 5
- 150000003077 polyols Chemical class 0.000 abstract description 5
- 230000002195 synergetic effect Effects 0.000 abstract description 4
- 230000002421 anti-septic effect Effects 0.000 abstract description 3
- 230000001954 sterilising effect Effects 0.000 abstract description 3
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 abstract 1
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- 235000011187 glycerol Nutrition 0.000 description 9
- 206010040880 Skin irritation Diseases 0.000 description 8
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- 231100000475 skin irritation Toxicity 0.000 description 8
- 230000006872 improvement Effects 0.000 description 7
- 239000003755 preservative agent Substances 0.000 description 7
- NCZPCONIKBICGS-UHFFFAOYSA-N 3-(2-ethylhexoxy)propane-1,2-diol Chemical compound CCCCC(CC)COCC(O)CO NCZPCONIKBICGS-UHFFFAOYSA-N 0.000 description 6
- 229940100524 ethylhexylglycerin Drugs 0.000 description 6
- 239000000344 soap Substances 0.000 description 5
- 238000005406 washing Methods 0.000 description 5
- 239000002585 base Substances 0.000 description 4
- 238000005260 corrosion Methods 0.000 description 4
- 238000011010 flushing procedure Methods 0.000 description 4
- 230000003020 moisturizing effect Effects 0.000 description 4
- 229940100555 2-methyl-4-isothiazolin-3-one Drugs 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 239000012467 final product Substances 0.000 description 3
- BEGLCMHJXHIJLR-UHFFFAOYSA-N methylisothiazolinone Chemical compound CN1SC=CC1=O BEGLCMHJXHIJLR-UHFFFAOYSA-N 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
- 206010012442 Dermatitis contact Diseases 0.000 description 2
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- VUWCWMOCWKCZTA-UHFFFAOYSA-N 1,2-thiazol-4-one Chemical class O=C1CSN=C1 VUWCWMOCWKCZTA-UHFFFAOYSA-N 0.000 description 1
- DHVLDKHFGIVEIP-UHFFFAOYSA-N 2-bromo-2-(bromomethyl)pentanedinitrile Chemical compound BrCC(Br)(C#N)CCC#N DHVLDKHFGIVEIP-UHFFFAOYSA-N 0.000 description 1
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- NIPNSKYNPDTRPC-UHFFFAOYSA-N N-[2-oxo-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 NIPNSKYNPDTRPC-UHFFFAOYSA-N 0.000 description 1
- 241000235342 Saccharomycetes Species 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
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- 239000003513 alkali Substances 0.000 description 1
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- 230000007815 allergy Effects 0.000 description 1
- 229940024606 amino acid Drugs 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
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- 230000001877 deodorizing effect Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
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- 238000004090 dissolution Methods 0.000 description 1
- WSDISUOETYTPRL-UHFFFAOYSA-N dmdm hydantoin Chemical compound CC1(C)N(CO)C(=O)N(CO)C1=O WSDISUOETYTPRL-UHFFFAOYSA-N 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 230000000369 enteropathogenic effect Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
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- 210000000245 forearm Anatomy 0.000 description 1
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- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 239000000174 gluconic acid Substances 0.000 description 1
- 235000012208 gluconic acid Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 239000008233 hard water Substances 0.000 description 1
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- 230000000774 hypoallergenic effect Effects 0.000 description 1
- 238000007373 indentation Methods 0.000 description 1
- 239000002563 ionic surfactant Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- 231100000760 phototoxic Toxicity 0.000 description 1
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Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a mild foam antibacterial hand sanitizer and a preparation method thereof. The hand sanitizer comprises the following components in percentage by mass: 5-15% of main surface active agent, 2-10% of auxiliary surface active agent, 4-12% of glycerol, 6-15% of conditioning agent, 5-10% of polyalcohol, 0.1-0.5% of bacteriostat, 0.5-1% of pH regulator, 0.5% of chelating agent, 0.2-1% of ethylhexyl glycerol and the balance of purified water. The alkyl glycoside is compounded with the disodium cocoyl amphodiacetate and the disodium cocoyl glutamate, so that the foaming power, the foam quantity and the foam stability of the hand sanitizer are improved, the hand sanitizer is easy to wash, and the irritation to skin is obviously reduced; the ethylhexyl glycerol and the polyalcohol are compounded, so that the surface tension of cells is changed, and the cells are better permeated into the cells to generate sterilization synergistic effect; the polyol is prepared by mixing 1, 3-propylene glycol, 1, 2-hexanediol and octyl glycol, so that the antiseptic requirement is met, and the antibacterial power of the hand sanitizer is enhanced. Therefore, the method has good application prospect.
Description
Technical Field
The invention belongs to the field of antibacterial hand sanitizers, and particularly relates to a mild foam antibacterial hand sanitizer and a preparation method thereof.
Background
Currently, the common antibacterial hand sanitizer products sold on the market can be divided into two types, one type is a soap base type, and the other type is a surfactant type. The soap base type hand sanitizer product has the characteristics of rich and fine foam, good detergency, easiness in flushing, dryness after use and the like, but the pH value of a soap base system is generally higher, the degreasing force is higher, and the soap base system has a tight feel after washing. The hand sanitizer product based on AES surfactant has moderate detergency and rich foam, but is slightly greasy after washing and has the feeling of unclean washing.
On the other hand, most of the hand sanitizers currently on the market use preservatives such as DMDMH, nipagin, isothiazolinones, phenoxyethanol, and the like. There are studies showing that preservatives are the second leading cause of cosmetic allergy and contact dermatitis, next to fragrances. Formaldehyde emitters, hydroxyphenyl esters, methyl chloroisothiamidazolone/methyl isothiazolinone, methyl dibromoglutaronitrile, etc. have all been found to cause allergic contact dermatitis in allergic people. With the intensive research on toxicology and safety of preservatives, adverse effects brought by some preservatives are becoming more important. In 2016, the European Union Commission issued a G/TBT/N/EU/332 report to the World Trade Organization (WTO) suggesting that methylisothiazolinone is prohibited from use in resident products. In 2017, the European Commission further adjusted the limits of methylisothiazolinone use for rinsing of the class of products.
In recent years, consumers pursue the formulation of mild and natural, and the call for the formulation is higher and higher, so that the development of the mild foam antibacterial hand sanitizer has important significance.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide the mild foam antibacterial hand sanitizer and the preparation method thereof, and the mild foam antibacterial hand sanitizer has the advantages of good antibacterial property, easiness in flushing, low irritation and strong moisture retention, and the preparation process is simple.
In order to solve the problems in the prior art, the invention adopts the following technical scheme:
the mild foam antibacterial hand sanitizer comprises the following components in percentage by mass: 5-15% of main surface active agent, 2-10% of auxiliary surface active agent, 4-12% of glycerol, 6-15% of conditioning agent, 5-10% of polyalcohol, 0.1-0.5% of bacteriostat, 0.5-1% of pH regulator, 0.5% of chelating agent, 0.2-1% of ethylhexyl glycerol and the balance of purified water, wherein the mass sum of all components is 100%.
As an improvement, the primary surfactant is an alkyl glycoside.
As an improvement, the alkyl glycoside is one or a mixture of more than one of octyl glucoside, decyl glucoside, coco glucoside or lauryl glucoside.
As an improvement, the auxiliary surfactant is formed by mixing disodium cocoyl amphodiacetate and disodium cocoyl glutamate according to the mass ratio of 0.5-2:1.
As an improvement, the conditioning agent is one or a mixture of more of sorbitol, dipropylene glycol, panthenol, allantoin and tocopherol.
The modified polyol is prepared by mixing 1, 3-propylene glycol, 1, 2-hexanediol and octanediol according to a mass ratio of 4-8:2-4:1.
As an improvement, the bacteriostatic agent is chlorhexidine gluconate.
As an improvement, the pH adjuster is citric acid.
As an improvement, the chelating agent is disodium edetate.
The preparation method of the mild foam antibacterial hand sanitizer comprises the following steps:
step 1, taking purified water, heating to 35-45 ℃, adding a main surface active agent and an auxiliary surface active agent, and stirring until the mixture is uniformly mixed;
step 2, sequentially adding glycerol, polyalcohol, ethylhexyl glycerol, a conditioner and a chelating agent, and stirring until the mixture is uniformly mixed;
step 3, adding a bacteriostat, and stirring until the bacteriostat and the bacteriostat are uniformly mixed;
and 4, finally, regulating the pH value of the system to 5.5-7 by using a pH regulator to obtain the mild foam antibacterial hand sanitizer.
The working principle of the invention is as follows:
the alkyl glycoside is a mild nonionic surfactant, is formed by dehydrating natural renewable resources fatty alcohol and glucose under an acidic catalyst, has good biodegradability, is favorable for environmental protection, and is an internationally recognized first-choice green functional surfactant. The foam has the advantages of rich and fine foam, good foam stabilizing performance, strong compatibility, obvious synergistic effect, strong broad-spectrum antibacterial activity, strong alkali resistance, strong salt resistance and the like.
The cocoyl amphodiacetate disodium is an ampholytic surfactant with very mild performance, low viscosity and low irritation, has excellent foaming force and foam stability, has excellent skin compatibility, and can give comfortable feeling to skin.
The cocoyl disodium glutamate is an amino acid surfactant prepared from natural fatty acid and natural L-glutamic acid, has the performances of emulsification, washing, dispersion, foaming, solubilization, dissolution and the like of an anionic surfactant, has excellent surface activity, and has the advantages of good adaptability to hard water, strong detergency, good wetting ability, high biodegradability, mild skin and no allergic reaction and phototoxic reaction.
The gluconic acid chloride has broad-spectrum antibacterial effect, the action mechanism is a permeation barrier adsorbed on bacterial plasma membrane, so that cell contents leak out to play an antibacterial effect, suppurative bacteria, enteropathogenic bacteria, common pathogenic bacteria infected by hospitals and pathogenic bacteria and pathogenic saccharomycetes in the air can be killed rapidly, and the antibacterial protective agent is suitable for long-acting sterilization protection of skin at hands and other parts. The low concentration has antibacterial effect, and the high concentration has antibacterial effect.
The ethylhexyl glycerol has good deodorizing effect, excellent moisturizing effect, proper wettability and good extensibility. Is a good antiseptic synergist, is often used together with polyalcohol, caters to the concept of 'no-additive' antiseptic, and has high safety.
The solubility, foaming performance and mildness of the alkyl glycoside selected by the invention are related to the carbon chain length, and when the carbon chain length is 8-10, the foaming performance and mildness are better and the influence of water quality is less; the alkyl glycoside is preferably octyl glucoside and decyl glucoside, because the solubility is high, the freezing point is low, and the liquid soap cannot precipitate when being stored at low temperature. Meanwhile, the compound cocoyl amphodiacetate disodium and cocoyl glutamic acid disodium have better compatibility, and the synergistic effect can ensure that the foaming force, the foam quantity and the foam stability of the hand sanitizer reach the best effect, and the hand sanitizer has excellent flushing performance and obviously reduces the irritation to skin.
On the other hand, the ethylhexyl glycerin has a moisturizing effect and an anti-corrosion and antibacterial effect, but the anti-corrosion capability is smaller than that of the traditional preservative, and the ethylhexyl glycerin is matched with the polyalcohol, so that the ethylhexyl glycerin better permeates into cells by changing the surface tension of the cells, and a synergistic effect is generated. More importantly, the selected polyalcohol is mixed by 1, 3-propanediol, 1, 2-hexanediol and octanediol, so that the anti-corrosion requirement of the hand sanitizer can be met, and the antibacterial capability of the hand sanitizer is enhanced; the bacteriostatic ability is enhanced with increasing ethylhexyl glycerin and polyol content.
The beneficial effects are that:
compared with the prior art, the mild foam antibacterial hand sanitizer and the preparation method thereof have the following advantages:
(1) The hand sanitizer is a weakly acidic alkyl glycoside surface active system, and can produce abundant foam by compounding mild disodium cocoyl amphodiacetate and disodium cocoyl glutamate, has low skin irritation, good decontamination performance, and good water solubility and is easy to wash.
(2) The hand sanitizer disclosed by the invention is free from adding traditional preservatives and adopts a polyol preservative system. The polyol and the ethylhexyl glycerol are used in a matched manner, so that the moisturizing effect and the antibacterial effect of the product can be improved, the product has smooth skin feel, a good anti-corrosion effect can be achieved, and the antibacterial capability of the product can be improved.
Drawings
Fig. 1 is a schematic flow chart of a preparation method of the foam antibacterial hand sanitizer.
Detailed Description
The following examples will provide those skilled in the art with a more complete understanding of the invention, but are not intended to limit the invention in any way.
Example 1
The mild foam antibacterial hand sanitizer comprises the following components in percentage by mass:
8% of main surface active agent, 6% of auxiliary surface active agent, 10% of glycerol, 12% of conditioning agent, 6% of polyalcohol, 0.5% of bacteriostat, 1% of pH regulator, 0.5% of chelating agent, 0.5% of ethylhexyl glycerol and the balance of purified water, wherein the mass sum of all components is 100%.
The main surface active agent is a mixture of octyl glucoside and decyl glucoside, and the mass ratio is 1:1.
The auxiliary surfactant is a mixture of disodium cocoyl amphodiacetate and disodium cocoyl glutamate, and the mass ratio of the auxiliary surfactant to the mixture is 1:1.
The conditioning agent is a mixture of sorbitol, dipropylene glycol, panthenol, allantoin and tocopherol, and the mass ratio is 40:20:1:1:1.
The polyalcohol is a mixture of 1, 3-propanediol, 1, 2-hexanediol and octanediol, and the mass ratio is 6:3:1.
The bacteriostatic agent is chlorhexidine gluconate.
The pH regulator is citric acid.
The chelating agent is disodium ethylenediamine tetraacetate.
The preparation method of the mild foam antibacterial hand sanitizer comprises the following steps:
(1) Adding purified water according to the formula amount, heating the water to 35-45 ℃, adding a main surface active agent and an auxiliary surface active agent, and stirring until the mixture is uniform;
(2) Sequentially adding glycerol, polyalcohol, ethylhexyl glycerol, conditioner and chelating agent, and stirring until the mixture is uniformly mixed;
(3) Sequentially adding the bacteriostat, and stirring until the bacteriostat and the bacteriostat are uniformly mixed;
(4) Adding pH regulator, and regulating pH to 5.5-7 to obtain the final product.
Example 2
The mild foam antibacterial hand sanitizer comprises the following components in percentage by mass:
10% of main surface active agent, 6% of auxiliary surface active agent, 8% of glycerin, 15% of conditioning agent, 8% of polyalcohol, 0.5% of bacteriostat, 1% of pH regulator, 0.5% of chelating agent, 1% of ethylhexyl glycerin and the balance of purified water, wherein the mass sum of all components is 100%.
The main surface active agent is a mixture of octyl glucoside and decyl glucoside, and the mass ratio is 1:1.
The auxiliary surfactant is a mixture of disodium cocoyl amphodiacetate and disodium cocoyl glutamate, and the mass ratio of the auxiliary surfactant to the mixture is 2:1.
The conditioning agent is a mixture of sorbitol, dipropylene glycol, panthenol, allantoin and tocopherol, and the mass ratio is 50:25:1:1:1.
The polyalcohol is a mixture of 1, 3-propanediol, 1, 2-hexanediol and octanediol, and the mass ratio is 8:4:1.
The bacteriostatic agent is chlorhexidine gluconate.
The pH regulator is citric acid.
The chelating agent is disodium ethylenediamine tetraacetate.
The preparation method of the mild foam antibacterial hand sanitizer comprises the following steps:
(1) Adding purified water according to the formula amount, heating the water to 35-45 ℃, adding a main surface active agent and an auxiliary surface active agent, and stirring until the mixture is uniform;
(2) Sequentially adding glycerol, polyalcohol, ethylhexyl glycerol, conditioner and chelating agent, and stirring until the mixture is uniformly mixed;
(3) Sequentially adding the bacteriostat, and stirring until the bacteriostat and the bacteriostat are uniformly mixed;
(4) Adding pH regulator, and regulating pH to 5.5-7 to obtain the final product.
Example 3
The mild foam antibacterial hand sanitizer comprises the following components in percentage by mass:
15% of main surface active agent, 5% of auxiliary surface active agent, 12% of glycerol, 9% of conditioning agent, 6% of polyalcohol, 0.5% of bacteriostat, 1% of pH regulator, 0.5% of chelating agent, 1% of ethylhexyl glycerol and the balance of purified water, wherein the mass sum of all components is 100%.
The main surface active agent is a mixture of octyl glucoside and decyl glucoside, and the mass ratio is 1:1.
The auxiliary surfactant is a mixture of disodium cocoyl amphodiacetate and disodium cocoyl glutamate, and the mass ratio of the auxiliary surfactant to the mixture is 1.5:1.
The conditioning agent is a mixture of sorbitol, dipropylene glycol, panthenol, allantoin and tocopherol, and the mass ratio is 50:20:2:2:1.
The polyalcohol is a mixture of 1, 3-propanediol, 1, 2-hexanediol and octanediol, and the mass ratio is 4:2:1.
The bacteriostatic agent is chlorhexidine gluconate.
The pH regulator is citric acid.
The chelating agent is disodium ethylenediamine tetraacetate.
The preparation method of the mild foam antibacterial hand sanitizer comprises the following steps:
(1) Adding purified water according to the formula amount, heating the water to 35-45 ℃, adding a main surface active agent and an auxiliary surface active agent, and stirring until the mixture is uniform;
(2) Sequentially adding glycerol, polyalcohol, ethylhexyl glycerol, conditioner and chelating agent, and stirring until the mixture is uniformly mixed;
(3) Sequentially adding the bacteriostat, and stirring until the bacteriostat and the bacteriostat are uniformly mixed;
(4) Adding pH regulator, and regulating pH to 5.5-7 to obtain the final product.
Test example 1
Foam antibacterial hand sanitizer use effect test
20 volunteers were selected, and the use effect of the product was evaluated in correspondence with the use of the hand sanitizers prepared in the groups 1 to 3 according to the present invention and the foam antibacterial hand sanitizers (hereinafter referred to as "commercial AES foam antibacterial hand sanitizers") which were prepared by using glycerin as a conditioner alone, and the feedback test results are shown in table 1 below:
table 1 results of the effect test
Note that: scores of 1-10 are scored, with higher scores indicating stronger corresponding attributes. Scoring reference: 1 min, very bad; 2 minutes, difference; 3 minutes, worse; 4, dividing into a grid; 5 minutes, and qualified; 6 minutes, better; 7 minutes, good; 8 minutes, very good; 9 minutes, excellent; 10 minutes, excellent.
The results show that the foam antibacterial hand sanitizer disclosed by the invention is rich and soft in foam, easy to wash, smooth and dry in hand feeling after washing hands, and the foam antibacterial hand sanitizer disclosed by the invention has a good moisturizing and skin care effect.
Test example 2
Skin irritation test
30 volunteers were selected, 0.5mL of the hand sanitizer prepared in the invention example 1-3 and the commercial AES foam antibacterial hand sanitizer were respectively smeared on the curved sides of the forearms, covered with double-layer gauze (2 cm multiplied by 2 cm) and fixed by hypoallergenic adhesive tapes, and the two layers were uniformly applied to the skin by palm light pressure for 24 hours. The skin irritation intensity levels were determined according to the criteria of table 2 at 30min after removal of the gauze (after disappearance of the indentations), 24h and 48h, respectively, and the test results are shown in table 3 below:
TABLE 2 skin irritation response grading criteria
TABLE 3 skin irritation test results
| Observation time | Example 1 | Example 2 | Example 3 | Commercial AES foam antibacterial hand sanitizer |
| 30min | 0 | 0 | 0 | 2 |
| 24h | 0 | 0 | 0 | 1 |
| 48h | 0 | 0 | 0 | 0 |
The results show that the foam antibacterial hand sanitizer provided by the invention has no positive reaction, the skin irritation grade is 0, and the commercially available AES foam antibacterial hand sanitizer has weak positive reaction, the skin irritation grade is 2, and the foam antibacterial hand sanitizer is slightly irritating. Compared with the commercial AES foam antibacterial hand sanitizer, the foam antibacterial hand sanitizer has the characteristics of low skin irritation and mild product.
Test example 3
Antibacterial test of foam antibacterial hand sanitizer
The antibacterial effect of the hand sanitizers prepared in the examples 1-3 of the invention and the commercial AES type foam antibacterial hand sanitizers were tested according to the method of the sterilizing technical Specification, 2002 edition 2.1.1, and the test results are shown in Table 4 below:
TABLE 4 antibacterial test results
In summary, the foam antibacterial hand sanitizer provided by the invention has an increased antibacterial effect with the increase of the content of the polyalcohol and the ethylhexyl glycerin, so that the antibacterial effect of the embodiment 2 is optimal. Compared with the commercial AES foam antibacterial hand sanitizer, the antibacterial effect is close. Therefore, the mild foam antibacterial hand sanitizer provided by the preparation method of the mild foam antibacterial hand sanitizer has the advantages of good antibacterial property, easiness in flushing, low irritation and strong moisture retention, and has a simple preparation process and a good application prospect.
Claims (10)
1. The mild foam antibacterial hand sanitizer is characterized by comprising the following components in percentage by mass: 5-15% of main surface active agent, 2-10% of auxiliary surface active agent, 4-12% of glycerol, 6-15% of conditioning agent, 5-10% of polyalcohol, 0.1-0.5% of bacteriostat, 0.5-1% of pH regulator, 0.5% of chelating agent, 0.2-1% of ethylhexyl glycerol and the balance of purified water, wherein the mass sum of all components is 100%.
2. A mild foam antibacterial hand sanitizer according to claim 1, wherein: the main surface active agent is alkyl glycoside.
3. A mild foam antibacterial hand sanitizer according to claim 2, wherein: the alkyl glycoside is one or more of octyl glucoside, decyl glucoside, coco glucoside or lauryl glucoside.
4. A mild foam antibacterial hand sanitizer according to claim 1, wherein: the auxiliary surfactant is formed by mixing disodium cocoyl amphodiacetate and disodium cocoyl glutamate according to the mass ratio of 0.5-2:1.
5. A mild foam antibacterial hand sanitizer according to claim 1, wherein: the conditioner is one or more of sorbitol, dipropylene glycol, panthenol, allantoin or tocopherol.
6. A mild foam antibacterial hand sanitizer according to claim 1, wherein: the polyalcohol is formed by mixing 1, 3-propanediol, 1, 2-hexanediol and octanediol according to the mass ratio of 4-8:2-4:1.
7. A mild foam antibacterial hand sanitizer according to claim 1, wherein: the bacteriostatic agent is chlorhexidine gluconate.
8. A mild foam antibacterial hand sanitizer according to claim 1, wherein: the pH regulator is citric acid.
9. A mild foam antibacterial hand sanitizer according to claim 1, wherein: the chelating agent is disodium ethylenediamine tetraacetate.
10. The preparation method of the mild foam antibacterial hand sanitizer based on the method disclosed in claim 1 is characterized by comprising the following steps: the method comprises the following steps:
step 1, taking purified water, heating to 35-45 ℃, adding a main surface active agent and an auxiliary surface active agent, and stirring until the mixture is uniformly mixed;
step 2, sequentially adding glycerol, polyalcohol, ethylhexyl glycerol, a conditioner and a chelating agent, and stirring until the mixture is uniformly mixed;
step 3, adding a bacteriostat, and stirring until the bacteriostat and the bacteriostat are uniformly mixed;
and 4, finally, regulating the pH value of the system to 5.5-7 by using a pH regulator to obtain the mild foam antibacterial hand sanitizer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311702099.5A CN117752543A (en) | 2023-12-11 | 2023-12-11 | Mild foam antibacterial hand sanitizer and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311702099.5A CN117752543A (en) | 2023-12-11 | 2023-12-11 | Mild foam antibacterial hand sanitizer and preparation method thereof |
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| Publication Number | Publication Date |
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| CN117752543A true CN117752543A (en) | 2024-03-26 |
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| CN202311702099.5A Pending CN117752543A (en) | 2023-12-11 | 2023-12-11 | Mild foam antibacterial hand sanitizer and preparation method thereof |
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| Country | Link |
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- 2023-12-11 CN CN202311702099.5A patent/CN117752543A/en active Pending
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