CN1177478A - Bath lotion containing total alkaloid of sophora alopecuroide - Google Patents
Bath lotion containing total alkaloid of sophora alopecuroide Download PDFInfo
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- CN1177478A CN1177478A CN 96119827 CN96119827A CN1177478A CN 1177478 A CN1177478 A CN 1177478A CN 96119827 CN96119827 CN 96119827 CN 96119827 A CN96119827 A CN 96119827A CN 1177478 A CN1177478 A CN 1177478A
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- bath lotion
- sophora alopecuroide
- total alkaloid
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Abstract
The present invention relates to a bath lotion containing total alkaloid of Sophora alopecuroides, which is characterized by that it comprises 20-30 portions of laurinol polyethenoxy ether, 5-10 portions of lauric diethanolamide, 2-3 portions of glycerin-modified tricocinin, 2-5 portions of octadecyltrimethyl ammonium chloride, 0.05-2.0 portions of total alkaloid of Sophora alopecuroides, 0.5-2.0 portions of essence and 55-77 portions of deionized water. Said invented bath lotion possesses several functions of bathing, protecting skin, sterilizing, disinfection and resisting static electricity.
Description
The present invention relates to a kind of bath lotion, particularly contain the bath lotion with bathing, skin protection, sterilization, sterilization, the multiple function of antistatic of sophora alopecuroide total alkaloids.
Raising along with people's living standard, skin cleaning, maintenance are required to use the bath lotion of science more, the bath lotion of multiple brand is arranged at present, in the city for a lot of convenience have been created in people's bathing, yet most bath lotion functions is more single, therefore still can not satisfy growing new requirement.
Purpose of the present invention is just in order to satisfy people's requirement new to bath lotion, and sophora alopecuroide total alkaloids and the kinds of surface activating agent selecting to have medical value carry out scientific compatibility, reach have bathing, skin protection, sterilization, sterilization, anlistatig multiple function.
The objective of the invention is to realize by following technical proposal:
A kind of bath lotion that contains the sophora alopecuroide total alkaloids is characterized in that it forms by following component and by following proportioning (by weight):
Polyoxyethylene lauryl ether 20-30 part, lauric acid diethyl amide 5-10 part, glycerin modification three cocinin 2-3 parts, octadecyl trimethyl ammonium chloride 2-5 part, total alkaloid of sophora alopecuroide 0.05-2.0 part, essence 0.5-2.0 part, deionized water 55-70 part.
Wherein total alkaloid of sophora alopecuroide be content more than 98%, surplus is the thick material of water, mainly contains matrine, sophocarpine and sophoridine.
The preparation method that contains the bath lotion of total alkaloid of sophora alopecuroide, it is characterized in that, it is undertaken by following order step: the deionized water that adds 55-70 part in the reactor of enamel chuck heating earlier, the polyoxyethylene lauryl ether that adds 20-30 part again, be heated to 50 ℃ ± 2, stirred 20-60 minute, add 0.05-2.0 part total alkaloid of sophora alopecuroide more successively, 5-10 part lauric acid diethyl amide, 2-5 part octadecyl trimethyl ammonium chloride, continue to stir 30-120 minute, be cooled to room temperature then, add 0.5-2.0 part essence, stir, the blowing bottling, packed products.
Total alkaloid of sophora alopecuroide raw material in the bath lotion of the present invention is the product of being developed by Kushen Biochemical Group Co Ltd, Inner Mongolian Autonomous Region, it is the alkaloid with pharmacologic action from the seed of Herba Sophorae alopecuroidis or stem and leaf extraction, mainly contain matrine matrine, sophoridine sophoridine, sophocarpine sophocapine, sophocarpine also claims the dehydrogenation matrine, the composite bath lotion that forms of surfactant that this total alkaloid of sophora alopecuroide and the present invention are used and deionized water, remove and have bathing, skin protection, the skin moistening effect also has the good sterilization bacteriostasis outward, for the pharmacologic action of total alkaloid of sophora alopecuroide is described, total alkaloid of sophora alopecuroide and deionized water are made into the solution of variable concentrations, with Midecamycin, chloromycetin compares, carried out the extracorporeal disinfecting bacteriostatic test, suppress the protozoon test, toxicological test, animal model test, existing division is as follows:
1. extracorporeal disinfecting bacteriostatic test:
According to cultivation and the identity principle of pathogen, the test that utilizes the following common infective pathogen body of from the clinical infection focus, separating to carry out, its result is as follows:
A) to staphylococcus aureus, Hemolytic streptococcus, dysentery bacterium, colibacillus, Bacillus proteus, hinder stopper rod bacterium, Ke Shi pneumobacillus, pseudomonas aeruginosa, micrococcus catarrhalis, gonococcus the bactericidal effect all arranged, minimum bactericidal concentration (MBC) is 1.0-.08mg/ml, minimum inhibitory concentration (MIC
90) be 0.12-0.029mg/ml.
B) minimum bactericidal concentration (MBC) to oxygen bacterium of going out such as peptococcus variabilis, clostridium tetani, bacteroides fragilis, distortion rib bacillus is 1.04-0.52mg/ml, minimum inhibitory concentration (MIC
90) be 0.06-0.03mg/ml, be 0.13-0.15mg/ml to the bacteroides fragilis minimum inhibitory concentration.
C) to red mentagrophytes, trichophyton tonsurans, microsporon gypseum. the minimum inhibitory concentration (MIC of Candida albicans
90) be 1.86-0.12mg/ml.
2. suppressing the protozoon test, is example with the trichomonas vaginitis, and with metronidazole, concentration is 2.5mg/ml, contrast test, and but minimum worm concentration is 0.06-0.1mg/ml, it acts on no significant difference.
3. to herpes simplex virus I I type and acquired immune deficiency syndrome (AIDS) I type (2 * 10
5TCID
50/ ml), do external sterilization with 0.16mg/ml concentration, demonstrate obvious effect.
4. toxicity test:
Give mice oral with the total alkaloid of sophora alopecuroide solution of 9.33mg/ml concentration, smear mouse part skin and the rabbit vagina mucosa carries out acute toxicity test with 18.66mg/ml concentration, zest and anaphylaxis laboratory observation, the result shows, mice and rabbit behavior, the food as usual, all do not find any toxicity, zest and anaphylactic reaction.
5. animal model test:
Make the rabbit vagina mucosa infected with Candida albicans, cause experimental rabbit toadstool property vaginitis, carry out the treatment same period respectively with 3.73mg/ml concentration and 10% normal saline respectively, the medication group is all cured, none the example recovery from illness of normal saline group, both differences are very obvious.
From above-mentioned result of the test show total alkaloid of sophora alopecuroide have obvious sterilization antibacterial, press down protozoon and antiviral effect, and can reach medicinal effects in extremely low amount ranges.
In order to further specify above-mentioned various effect, carried out clinical observation and actual bacteriostatic test again, existing division is as follows:
1. clinical observation: undertaken by Kushen Biochemical Group Co Ltd, Inner Mongolian Autonomous Region's polyclinic.
Clinical case 251 examples, the sick kind is gynaecopathia 180 examples, sick 71 examples of department of dermatologry, patient every day 1-3 time, per seven days is a course of treatment, the clinical effectiveness that passes through after 2-3 the course of treatment is as follows: see Table 1
Table 1
| Sick section | The sick kind | Case load | Effective case load | Effective percentage % |
| Gynaecopathia | Trichomonal vaginitis | ????77 | ????66 | ????85.7 |
| Colpitis mycotica | ????54 | ????42 | ????77.3 | |
| Pudendal pruritus | ????16 | ????13 | ????81.3 | |
| Cervical erosion | ????33 | ????28 | ????84.8 | |
| Cutaneous diseases | Eczema | ????7 | ????6 | ????35.7 |
| Neurodermatitis | ????3 | ????2 | ????66.7 | |
| Pus miliaria | ????15 | ????14 | ????98.3 | |
| Impetigo | ????2 | ????2 | ????100 | |
| Dense skin ulcer rash | ????5 | ????5 | ????100 | |
| Brothers' tinea corporis | ????28 | ????22 | ????78.6 | |
| Acne of youth | ????9 | ????6 | ????66.7 | |
| Scabies | ????2 | ????2 | ????100 |
Clinical observation shows that the pharmacologic action of total alkaloid of sophora alopecuroide is significantly, through curative effect is preferably all arranged 1-2 the course of treatment.
2. actual bacteriostatic test:
Test method: the white plaque of 10 * 10cm is cleaned, sterilized, then escherichia coli are mixed with 100,000 bacterium/ml solution, getting 1ml is evenly coated on the porcelain plate surface, natural drying, simulate the human bathing mode then, with bath lotion of the present invention washing, according to different time 5,10,15,20 minutes, get sterile saline with the disinfecting silk or cotton rod libation at an ancient wedding ceremony, washing porcelain plate 1cm
2, and then this cotton rod washed in quantitative sterile saline, according to the bacterium number what, whether decision dilutes again, count of bacteria method routinely is inoculated in the plain agar plate then, is converted to the residual antibacterial number/cm of porcelain plate at last
2, the results are shown in Table 2:
Table 2
| Group | The bath lotion title | Antibacterial number/cm on the different residual porcelain plates of shower time | |||
| 5 minutes | 10 minutes | 15 minutes | 20 minutes | ||
| Test group | Bath lotion of the present invention | ????300 | ??80 | ??50 | ??10 |
| Matched group | The bath lotion that does not contain total alkaloid of sophora alopecuroide | ????500 | ??150 | ??100 | ??70 |
| Blank group | Normal saline | ????750 | ??550 | ??300 | ??150 |
Significance analysis:
D、F＝6，CHISQUARE＝145.5442
1, liang group contrast P＜0.0001,2 liang of group contrast p＜0.01,1,3
By above-mentioned result of the test and table 1 table 2 result, prove absolutely, bath lotion of the present invention is except that the clean skin with general bath lotion, skin moistening function, also have extremely strong sterilization, antibacterial, disinfective action, and skin there are not any stimulation, effect such as residual, the result shows by significance analysis, and the sterilization of bath lotion of the present invention, bacteriostasis and matched group and blank group have extremely significant difference.
Polyoxyethylene lauryl ether that bath lotion of the present invention is used and glycerin modification three cocinins are the non-ionic surface activator, lauric acid diethyl amide is an anion surfactant, octadecyl trimethyl ammonium chloride is a cationic surfactant, the infiltration of emulsifying is preferably all arranged, increase fat, the effect of skin protection also has antistatic property simultaneously, bring into play better effect after composite, make bath lotion of the present invention have multiple function.
Technology of the present invention compared with the prior art, it is complete to have function, effective, preparation method is simple, high product quality advantages.
Embodiment 1:
At first in enamel chuck reacting by heating still, add deionized water 55kg, add the 20kg polyoxyethylene lauryl ether again, be heated to 50 ℃ ± 2, stirred 20 minutes, add 0.05kg total alkaloid of sophora alopecuroide, 10kg lauric acid diethyl amide, 3kg glycerin modification three cocinins, 5kg octadecyl trimethyl ammonium chloride more successively, continue to stir 120 minutes, be cooled to room temperature then, add 0.5kg essence, stir, the blowing bottling, packed products.
Embodiment 2:
In above-mentioned reactor, the first-selected deionized water 65kg that adds adds the 25kg polyoxyethylene lauryl ether again, is heated to 50 ℃ ± 2, stirred 40 minutes, add 1.0kg total alkaloid of sophora alopecuroide, 8kg lauric acid diethyl amide, 2kg glycerin modification three cocinins, 3kg octadecyl trimethyl ammonium chloride more successively, continue to stir 80 minutes, be cooled to room temperature then, add 1kg essence, stir blowing bottling, packed products.
Embodiment 3:
In above-mentioned reactor, at first add deionized water 70kg, add the 30kg polyoxyethylene lauryl ether again, be heated to 50 ℃ ± 2, stirred 60 minutes, add 2.0kg total alkaloid of sophora alopecuroide, 5kg lauric acid diethyl amide, 2kg glycerin modification three cocinins, 2kg octadecyl trimethyl ammonium chloride more successively, continue to stir 80 minutes, be cooled to room temperature then, add 2kg essence, stir blowing bottling, packed products.
Claims (3)
1, a kind of bath lotion that contains the sophora alopecuroide total alkaloids is characterized in that it forms by following component and by following proportioning (by weight):
Polyoxyethylene lauryl ether 20-30 part, lauric acid diethyl amide 5-10 part, glycerin modification three cocinin 2-3 parts, octadecyl trimethyl ammonium chloride 2-5 part, sophora alopecuroide total alkaloids 0.05-2.0 part, essence 0.5-2.0 part, deionized water 55-70 part.
2, bath lotion according to claim 1 is characterized in that the sophora alopecuroide total alkaloid content is more than 98%, and surplus is the thick material of water, mainly contains matrine, sophocarpine and sophoridine.
3, the preparation method of bath lotion as claimed in claim 1, the preparation method that contains the bath lotion of total alkaloid of sophora alopecuroide, it is characterized in that, it is by following order, step is carried out: the deionized water that adds 55-70 in the reactor of enamel chuck heating earlier, the polyoxyethylene lauryl ether that adds 20-30 part again, be heated to 50 ℃ ± 2, stirred 20-60 minute, add 0.05-2.0 part total alkaloid of sophora alopecuroide more successively, 5-10 part lauric acid diethyl amide, 2-5 part octadecyl trimethyl ammonium chloride, continue to stir 30-120 minute, be cooled to room temperature then, add 0.5-2.0 part essence, stir, the blowing bottling, packed products.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96119827A CN1095362C (en) | 1996-09-26 | 1996-09-26 | Bath lotion containing total alkaloid of sophora alopecuroide |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96119827A CN1095362C (en) | 1996-09-26 | 1996-09-26 | Bath lotion containing total alkaloid of sophora alopecuroide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1177478A true CN1177478A (en) | 1998-04-01 |
| CN1095362C CN1095362C (en) | 2002-12-04 |
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ID=5125975
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN96119827A Expired - Fee Related CN1095362C (en) | 1996-09-26 | 1996-09-26 | Bath lotion containing total alkaloid of sophora alopecuroide |
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| CN (1) | CN1095362C (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7381429B2 (en) * | 2000-06-29 | 2008-06-03 | Dr. Willmar Schwabe Gmbh & Co. | Extracts from sophora species, method for producing the same and their use |
| KR100837682B1 (en) * | 2006-03-08 | 2008-06-13 | 한국과학기술연구원 | An antibacterial and antifungal composition containing Dracocephalum foetidum extracts, Sophora alopecuroides extracts or fractions thereof |
| CN102038668A (en) * | 2010-12-03 | 2011-05-04 | 沈阳药科大学 | Lauric acid diethanolamide and application of analog thereof |
| CN101444568B (en) * | 2008-12-31 | 2012-05-09 | 内蒙古永业生物技术有限责任公司 | Method for preparing Sophora alopecuroides skin bacteriostasis spray |
| CN106176362A (en) * | 2016-07-25 | 2016-12-07 | 深圳先进技术研究院 | A kind of Herba Sophorae alopecuroidis antibiotic skincare hand cleanser and preparation method thereof |
| CN113288896A (en) * | 2021-05-28 | 2021-08-24 | 成都中医药大学 | Application of sophoridine in preparation of anti-herpes virus medicine |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1096945A (en) * | 1993-06-30 | 1995-01-04 | 李谦德 | Natural cold-type yellow (clear) liquor for washing hair or skin manufacture method |
| CN1059563C (en) * | 1994-06-02 | 2000-12-20 | 中国人民解放军三○二医院 | Gonorrhoea eliminating and bacteriostatic bathing liquor containing Chinese drug and its preparing method |
-
1996
- 1996-09-26 CN CN96119827A patent/CN1095362C/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7381429B2 (en) * | 2000-06-29 | 2008-06-03 | Dr. Willmar Schwabe Gmbh & Co. | Extracts from sophora species, method for producing the same and their use |
| KR100837682B1 (en) * | 2006-03-08 | 2008-06-13 | 한국과학기술연구원 | An antibacterial and antifungal composition containing Dracocephalum foetidum extracts, Sophora alopecuroides extracts or fractions thereof |
| CN101444568B (en) * | 2008-12-31 | 2012-05-09 | 内蒙古永业生物技术有限责任公司 | Method for preparing Sophora alopecuroides skin bacteriostasis spray |
| CN102038668A (en) * | 2010-12-03 | 2011-05-04 | 沈阳药科大学 | Lauric acid diethanolamide and application of analog thereof |
| CN106176362A (en) * | 2016-07-25 | 2016-12-07 | 深圳先进技术研究院 | A kind of Herba Sophorae alopecuroidis antibiotic skincare hand cleanser and preparation method thereof |
| CN113288896A (en) * | 2021-05-28 | 2021-08-24 | 成都中医药大学 | Application of sophoridine in preparation of anti-herpes virus medicine |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1095362C (en) | 2002-12-04 |
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