CN117677402A - 用于使用超声雾化器施用用于预防或治疗包括covid-19的呼吸道病毒感染、由病毒感染引起的肺纤维化或呼吸道疾病的双链寡核苷酸结构的组合物 - Google Patents

用于使用超声雾化器施用用于预防或治疗包括covid-19的呼吸道病毒感染、由病毒感染引起的肺纤维化或呼吸道疾病的双链寡核苷酸结构的组合物 Download PDF

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Publication number
CN117677402A
CN117677402A CN202280030335.0A CN202280030335A CN117677402A CN 117677402 A CN117677402 A CN 117677402A CN 202280030335 A CN202280030335 A CN 202280030335A CN 117677402 A CN117677402 A CN 117677402A
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CN
China
Prior art keywords
pharmaceutical composition
double
stranded oligonucleotide
samirna
bond
Prior art date
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Pending
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CN202280030335.0A
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English (en)
Chinese (zh)
Inventor
H·O·帕克
S·K·李
S·I·尹
O·S·权
E·A·高
Y·H·高
J·H·帕克
K·宋
J·金
M·S·李
S·J·崔
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Tolerance Gene
Bioneer Corp
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Tolerance Gene
Bioneer Corp
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Publication of CN117677402A publication Critical patent/CN117677402A/zh
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CN202280030335.0A 2021-03-08 2022-03-08 用于使用超声雾化器施用用于预防或治疗包括covid-19的呼吸道病毒感染、由病毒感染引起的肺纤维化或呼吸道疾病的双链寡核苷酸结构的组合物 Pending CN117677402A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR10-2021-0029927 2021-03-08
KR20210029927 2021-03-08
PCT/KR2022/003245 WO2022191567A1 (ko) 2021-03-08 2022-03-08 Covid-19를 포함하는 호흡기 바이러스 감염증, 바이러스 감염에 의한 폐섬유증, 또는 호흡기 질환 예방 또는 치료를 위한 초음파 방식 연무식 흡입기를 이용한 이중가닥 올리고뉴클레오티드 구조체 투여용 조성물

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CN117677402A true CN117677402A (zh) 2024-03-08

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CN202280030335.0A Pending CN117677402A (zh) 2021-03-08 2022-03-08 用于使用超声雾化器施用用于预防或治疗包括covid-19的呼吸道病毒感染、由病毒感染引起的肺纤维化或呼吸道疾病的双链寡核苷酸结构的组合物

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US (1) US20250066787A1 (enExample)
EP (1) EP4306133A4 (enExample)
JP (1) JP2024509906A (enExample)
KR (1) KR102570826B1 (enExample)
CN (1) CN117677402A (enExample)
CA (1) CA3210813A1 (enExample)
WO (1) WO2022191567A1 (enExample)

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BR112022023408A2 (pt) * 2020-05-22 2023-01-31 Bioneer Corp Oligonucleotídeo de fita dupla e composição para tratar covid-19 contendo o mesmo

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101287835A (zh) 2005-08-17 2008-10-15 株式会社百奥尼 用于siRNA细胞内输送的siRNA-亲水性聚合物结合物及其方法
WO2009045457A2 (en) * 2007-10-02 2009-04-09 Rxi Pharmaceuticals Corp. Tripartite rnai constructs
NZ585784A (en) 2007-12-13 2012-09-28 Alnylam Pharmaceuticals Inc siRNAs for the treatment and prevention of respiratory syncytial virus (RSV) infection
KR101224828B1 (ko) 2009-05-14 2013-01-22 (주)바이오니아 ｓｉＲＮＡ 접합체 및 그 제조방법
US20120225129A1 (en) * 2010-08-20 2012-09-06 Cerulean Pharma Inc. Conjugates, particles, compositions, and related methods
CA2917299C (en) * 2013-07-05 2020-07-21 Bioneer Corporation Improved nanoparticle type oligonucleotide structure having high efficiency and method for preparing same
RU2656154C2 (ru) * 2013-07-05 2018-05-31 Байонир Корпорейшн СВЯЗАННАЯ С РЕСПИРАТОРНЫМ ЗАБОЛЕВАНИЕМ ГЕН-СПЕЦИФИЧЕСКАЯ миРНК, ДВУСПИРАЛЬНАЯ КОНСТРУКЦИЯ ОЛИГО-РНК, СОДЕРЖАЩАЯ миРНК, И СОДЕРЖАЩАЯ ЕЕ КОМПОЗИЦИЯ ДЛЯ ПРЕДУПРЕЖДЕНИЯ ИЛИ ЛЕЧЕНИЯ РЕСПИРАТОРНОГО ЗАБОЛЕВАНИЯ
WO2015152693A2 (ko) * 2014-04-04 2015-10-08 (주)바이오니아 신규 이중 나선 올리고 rna 및 이를 포함하는 섬유증 또는 호흡기 질환의 예방 또는 치료용 약학조성물
CN108162349A (zh) 2017-12-25 2018-06-15 江苏君华特种工程塑料制品有限公司 一种适用于齿科牙盘的peek改性材料的制备方法
MY199134A (en) * 2018-05-25 2023-10-17 Bioneer Corp Amphiregulin gene-specific double-stranded oligonucleotide and composition for preventing and treating fibrosis related diseases and respiratory diseases, comprising same
KR102473989B1 (ko) * 2018-11-28 2022-12-07 (주)바이오니아 안드로젠 수용체 특이적 서열을 포함하는 이중나선 올리고뉴클레오티드 구조체, 및 이를 포함하는 탈모 예방 및 발모용 조성물

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