CN117653809A - Blood cooling device, extracorporeal circulation system and blood cooling method - Google Patents
Blood cooling device, extracorporeal circulation system and blood cooling method Download PDFInfo
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- CN117653809A CN117653809A CN202310949746.6A CN202310949746A CN117653809A CN 117653809 A CN117653809 A CN 117653809A CN 202310949746 A CN202310949746 A CN 202310949746A CN 117653809 A CN117653809 A CN 117653809A
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- 238000001816 cooling Methods 0.000 title claims abstract description 256
- 239000008280 blood Substances 0.000 title claims abstract description 77
- 210000004369 blood Anatomy 0.000 title claims abstract description 77
- 230000004087 circulation Effects 0.000 title claims abstract description 19
- 230000007246 mechanism Effects 0.000 claims abstract description 56
- 230000017531 blood circulation Effects 0.000 claims abstract description 4
- 239000012530 fluid Substances 0.000 claims abstract description 4
- 238000000034 method Methods 0.000 claims description 12
- 230000008569 process Effects 0.000 claims description 7
- 230000000694 effects Effects 0.000 claims description 5
- 238000004781 supercooling Methods 0.000 claims description 5
- 230000000149 penetrating effect Effects 0.000 claims description 3
- 238000001514 detection method Methods 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 238000010586 diagram Methods 0.000 description 8
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- 206010021143 Hypoxia Diseases 0.000 description 1
- 206010022822 Intravascular haemolysis Diseases 0.000 description 1
- 208000001647 Renal Insufficiency Diseases 0.000 description 1
- 208000030886 Traumatic Brain injury Diseases 0.000 description 1
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- 238000002618 extracorporeal membrane oxygenation Methods 0.000 description 1
- 238000002695 general anesthesia Methods 0.000 description 1
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- 238000010438 heat treatment Methods 0.000 description 1
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Abstract
The invention discloses a blood cooling device, an extracorporeal circulation system and a blood cooling method, wherein the blood cooling device comprises a cooling mechanism and a cooling box for heat exchange between a blood flow and the cooling mechanism, and the cooling box is detachably arranged in a fixed bin; the cooling mechanism comprises a cooling bin internally provided with refrigerating fluid and a cooling component for cooling the cooling bin, and one side of the cooling bin, which is away from the cooling box, is provided with an adjusting mechanism for driving the cooling bin to be close to or far away from the cooling box; according to the invention, the cooling box is detachably arranged in the fixed bin, the cooling bin is driven by the adjusting mechanism to move for adjusting the distance between the cooling box and the cooling box, and when the power of the cooling assembly is fixed, the cooling rate of blood can be adjusted, so that the cooling requirements under different clinical conditions are met.
Description
Technical Field
The invention relates to the technical field of medical equipment, in particular to a blood cooling device, an extracorporeal circulation system and a blood cooling method.
Background
In clinic, for example, in the treatment of cardiopulmonary resuscitation, general anesthesia extracorporeal circulation surgery, ECMO, severe craniocerebral injury, heat-shock disease, CRRT, it is necessary to cool the patient's blood to slow down tissue hypoxia and metabolite accumulation, thereby protecting the function of vital organs. For patients with liver and kidney insufficiency, intravascular hemolysis and the like, the extracorporeal circulation, blood perfusion and the like of the patients are required, and the blood can be cooled to protect the physical health of the patients. Patients suffering from severe infection or other causes with high fever may also suffer from high fever, high temperature and the like, and the body temperature needs to be controlled by cooling to protect the functions of important organs.
At present, the clinical method mainly comprises the following steps of: 1. the disadvantage of wiping bath and cooling by ice bags is that the cooling is uncontrollable, and the temperature loss or frostbite and the like can occur; 2. the indirect cooling modes such as ice caps and ice blankets have the defects that the method belongs to indirect cooling, the core temperature of a patient is reduced slowly and cannot be controlled accurately, most of cooling by using a compressor has high heat conversion efficiency, but the equipment has large volume and large noise and has the risk of cross infection; 3. in the extracorporeal circulation process, the membrane lung is cooled, so that the blood temperature is indirectly reduced, and finally the human body temperature is reduced, and the extracorporeal circulation device has the defects of high price and low cooling efficiency because the extracorporeal circulation device is used together with an artificial membrane lung. The method also uses a compressor to cool, the noise and the equipment volume are larger, and meanwhile, in the existing extracorporeal circulation pipeline, only a heating device is generally arranged, and a cooling device for blood is not arranged, so that the current clinical actual requirements can not be completely met.
Disclosure of Invention
The technical purpose is that: aiming at the defects of the existing clinical blood cooling mode, the invention discloses a blood cooling device, an extracorporeal circulation system and a blood cooling method, which can directly and rapidly cool blood to meet the requirement and can adjust the cooling rate according to the requirement.
The technical scheme is as follows: in order to achieve the technical purpose, the invention adopts the following technical scheme:
the blood cooling device comprises a cooling mechanism and a cooling box for heat exchange between a blood flow and the cooling mechanism, wherein the cooling box is detachably arranged in a fixed bin; the cooling mechanism comprises a cooling bin with refrigerating fluid inside and a cooling component for cooling the cooling bin, and an adjusting mechanism for driving the cooling bin to approach or keep away from the cooling box is arranged on one side of the cooling bin away from the cooling box.
Preferably, the adjusting mechanism comprises a guide block which is arranged along the surface parallel to the cooling bin, a linear driving mechanism which drives the guide block to move along the direction parallel to the cooling bin, and a driving component which is used for being matched with the guide block to convert the linear movement of the guide block into the movement perpendicular to the direction of the cooling bin, wherein the driving component is connected with the cooling bin and drives the cooling bin to be close to or far away from the cooling box when the guide block slides.
Preferably, the driving assembly comprises a guide groove arranged in a guide block, wherein the guide groove is obliquely arranged in the guide block along the direction facing the cooling bin, a guide column matched with the groove width of the guide groove is arranged in the guide groove in a penetrating manner, the end part of the guide column is fixedly connected with the cooling bin, and a limiting U-shaped frame used for limiting two sides of the cooling bin perpendicular to the moving direction is arranged on the outer side of the cooling bin.
Preferably, a slot for loading the cooling box is arranged in the fixed bin, a locking mechanism for locking and unlocking the position of the cooling box is arranged between the cooling box and the slot, the locking mechanism comprises a sliding block, a locking block and a rebound hook, the locking block is arranged on the cooling box, the sliding block is in sliding connection with the fixed bin along the loading direction parallel to the cooling box, one end of the rebound hook is in rotating connection with the sliding block, the other end of the rebound hook faces to one side of an opening of the slot, and an elastic driving assembly for driving the rebound hook to rotate for locking and unlocking the cooling box when the sliding block slides is arranged in the fixed bin.
Preferably, the elastic driving assembly comprises a containing groove arranged on the fixed bin and a first reset spring arranged on the sliding block, wherein the containing groove is positioned on one side of the rebound hook, which is away from the locking block, the first reset spring is positioned on the other side of the rebound hook, one end of the first reset spring is fixedly connected with the sliding block, the other end of the first reset spring is fixedly connected with the rebound hook, when the sliding block drives the rebound hook to move towards the inner side of the slot, the rebound hook is separated from the containing groove and rotates towards one side where the locking block is positioned, and the locking block and a cooling box connected with the locking block are limited in the slot.
Preferably, a sliding hook for positioning the sliding position of the sliding block and a second reset spring for resetting the sliding block are arranged on the fixed bin, one end of the second reset spring is fixedly connected with the sliding block, the other end of the second reset spring is fixedly connected with the inner wall of the fixed bin, the sliding hook is positioned on the other side of the sliding block relative to the second reset spring, and the sliding block is limited in position through the sliding hook after sliding in place.
Preferably, the surface of the sliding block is provided with a special-shaped groove, the special-shaped groove is provided with a concave area matched with the end part of the sliding hook, and when the sliding block slides, the sliding hook enters the concave area of the special-shaped groove from the end part of the sliding block.
Preferably, the locking block and the sliding block are matched through the wedge-shaped inclined plane, and when the cooling box is installed in the slot, the sliding block is pushed to move through the locking block, and the rebound hook is automatically driven to rotate to limit the locking block.
Preferably, the number of the cooling mechanisms is two, the cooling mechanisms are symmetrically arranged on two sides of the fixed bin, the cooling boxes are synchronously cooled, and the number of the adjusting mechanisms is matched with the number of the cooling mechanisms.
The invention discloses an extracorporeal circulation system, which is provided with the blood cooling device, wherein the blood cooling device is arranged on a venous side blood circuit of the extracorporeal circulation system, and a temperature measuring structure is arranged at a blood inlet and outlet of the blood cooling device to detect the temperature.
The invention also provides a blood cooling method, which uses the blood cooling device, detects the inlet blood temperature of the blood cooling device through a temperature measuring structure, adjusts the distance between the cooling bin and the cooling box according to the cooling requirement, and keeps the outlet blood temperature of the blood cooling device to meet the requirement; when the supercooling phenomenon occurs, the cooling box is directly ejected from the fixed bin; the process of adjusting the distance between the cooling bin and the cooling box comprises the following steps: the linear driving mechanism is started, the guide block is driven to horizontally move through the linear driving mechanism, when the guide block moves, acting force is applied to the guide column through the guide groove, the guide column is driven to move along the inclined direction of the guide groove, and the cooling bin is driven to be close to or far away from the cooling box through changing the moving direction of the guide block.
Preferably, the process of ejecting the cooling box from the fixed bin comprises the following steps: loosening the slip of locking sliding block and colluding, under the pulling force effect of second reset spring, driving the sliding block and resetting, at the sliding block in-process that resets, promote the cooling box through with locking piece complex wedge inclined plane and remove outside the fixed storehouse, the rebound colludes and moves along with the sliding block is synchronous, after removing to the holding tank, under the thrust effect of first reset spring, the rebound colludes and rotates and get into the holding tank, takes out the cooling box from the fixed storehouse.
The beneficial effects are that: the blood cooling device, the extracorporeal circulation system and the blood cooling method provided by the invention have the following beneficial effects:
1. according to the invention, the cooling box is detachably arranged in the fixed bin, the cooling bin is driven by the adjusting mechanism to move for adjusting the distance between the cooling box and the cooling box, and when the power of the cooling assembly is fixed, the cooling rate of blood can be adjusted, so that the cooling requirements under different clinical conditions are met.
2. According to the invention, the guide grooves are matched with the guide columns, so that the parallel movement of the guide blocks is converted into the vertical movement of the cooling bin, the distance adjustment is realized, the occupied space of the equipment can be saved compared with a mode of directly using linear driving, and meanwhile, the two groups of guide columns can ensure the stable movement of the cooling bin and avoid deflection.
3. The cooling box is detachable, can be used as a disposable consumable, and avoids cross infection.
4. According to the invention, the locking mechanism is used for fixing and detaching the cooling box, so that the cooling box and the fixing bin can be assembled and detached quickly, and the cooling box can be ejected out quickly when the cooling assembly is damaged or supercooling occurs, thereby avoiding supercooling of blood.
5. According to the invention, the locking block is matched with the sliding block through the wedge-shaped inclined plane, so that the sliding block can be automatically pushed to move by the locking block when the cooling box is packaged, the rebound hook is driven to rotate to lock the cooling box, the difficulty of assembly is reduced, and the synchronization of assembly and fixation is realized.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below.
FIG. 1 is a view showing the whole structure of a blood cooling apparatus according to the present invention;
FIG. 2 is a diagram showing a structure of a blood cooling apparatus according to a second embodiment of the present invention;
FIG. 3 is a schematic diagram of a cooling box according to the present invention;
FIG. 4 is a block diagram of a fixed bin of the present invention;
FIG. 5 is a view showing the assembled state of the cooling box and the fixed bin of the invention;
FIG. 6 is a block diagram of an adjustment mechanism of the present invention;
FIG. 7 is a block diagram of a locking mechanism of the present invention;
FIG. 8 is a partial block diagram of the cooperation of the rebound hook and the slider of the present invention;
FIG. 9 is a schematic view of a blood cooling apparatus housing according to the present invention;
FIG. 10 is a block diagram of a refrigerator according to the present invention;
FIG. 11 is a schematic diagram of the extracorporeal circulation system according to the present invention;
the device comprises a 1-cooling box, a 2-fixed bin, a 3-cooling bin, a 4-guide block, a 5-linear driving mechanism, a 6-guide groove, a 7-guide column, an 8-limit U-shaped frame, a 9-slot, a 10-sliding block, an 11-locking block, a 12-rebound hook, a 13-containing slot, a 14-first reset spring, a 15-sliding hook, a 16-second reset spring, a 17-special-shaped groove, a 18-shell, a 19-arterial side blood circuit, a 20-filter, a 21-venous side blood circuit, a 22-waste liquid circuit, a 23-replacement liquid circuit and a 24-dialysate circuit.
Description of the embodiments
The present invention will now be described more fully hereinafter with reference to the accompanying drawings, in which preferred embodiments of the invention are shown, but in which the invention is not so limited.
As shown in fig. 1-10, the blood cooling device disclosed by the invention comprises a cooling mechanism and a cooling box 1 for heat exchange between a blood flow and the cooling mechanism, wherein a blood conveying pipeline is fixed in the cooling box 1 in a spiral coil shape, and the cooling box 1 is detachably arranged in a fixed bin 2; the cooling mechanism comprises a cooling bin 3 with refrigerating fluid inside and a cooling component for cooling the cooling bin 3, and an adjusting mechanism for driving the cooling bin 3 to approach or separate from the cooling box 1 is arranged on one side of the cooling bin 3 away from the cooling box 1.
The cooling component comprises a refrigerator and a circulating pump, wherein the refrigerator is provided with a water inlet port and a water outlet port, the structure of the refrigerator is shown in fig. 8, the refrigerator is a refrigeration compressor or a refrigeration semiconductor, and other refrigeration devices can be adopted, so long as the refrigeration effect can be realized. Preferably, in the present embodiment, the semiconductor refrigeration assembly is used as a constant temperature source, no refrigerant is needed, no pollution source is needed, and continuous operation is possible.
The refrigerator is provided with a temperature measuring device for monitoring the water temperature of cooling water, the temperature measuring device comprises a thermocouple or a thermistor, the refrigerator further comprises a temperature control unit, the temperature control unit receives a temperature signal returned by the temperature measuring device and judges whether cooling capacity is required to be provided according to the temperature signal so as to maintain the low-temperature environment in the constant-temperature cavity; the cooling bin 3 is provided with a water inlet and a water outlet, the water inlet is connected with a water outlet interface of the refrigerator through a cooling pipe, the water outlet is connected with a water inlet interface of the refrigerator through a return pipe, the circulating pump is used for providing circulating power of cooling water for continuous cooling, in order to improve cooling efficiency, as shown in fig. 2, a group of cooling mechanisms can be respectively arranged on the left side and the right side of the cooling box 1 in another embodiment of the invention, the cooling mechanisms are symmetrically arranged on the two sides of the fixed bin, the cooling boxes are synchronously cooled, and the number of the adjusting mechanisms is matched with that of the cooling mechanisms.
In practical use, the cooling bin 3 can be directly driven to move by using a structure with linear driving capability, but the space required by direct driving is larger, and the single linear driving cannot guarantee the stable movement of the cooling bin 3, so that, as shown in fig. 4, the adjusting mechanism comprises a guide block 4 arranged along the surface parallel to the cooling bin 3, a linear driving mechanism 5 for driving the guide block 4 to move along the direction parallel to the cooling bin 3, and a driving component for converting the linear movement of the guide block 4 into the movement perpendicular to the direction of the cooling bin 3 by matching with the guide block 4, wherein in the embodiment of the invention, the linear driving mechanism 5 adopts a linear motor, the driving component is connected with the cooling bin 3, and drives the cooling bin 3 to be close to or far away from the cooling box 1 when the guide block 4 slides.
The driving assembly comprises a guide groove 6 arranged in a guide block 4, wherein the guide groove 6 is obliquely arranged in the guide block 4 along the direction facing a cooling bin 3, a guide column 7 matched with the groove width of the guide groove 6 is arranged in the guide groove 6 in a penetrating manner, the end part of the guide column 7 is fixedly connected with the cooling bin 3, and a limiting U-shaped frame 8 used for limiting two sides of the cooling bin 3 perpendicular to the moving direction is arranged on the outer side of the cooling bin 3.
The invention sets the cooling box 1 into a detachable structure, and can adopt disposable consumable materials to the cooling box 1 under the condition of keeping the cooling mechanism unchanged, thereby avoiding cross infection while ensuring cleaning, arranging a protective shell 18 on the outer side of the blood cooling device, arranging a slot 9 for loading the cooling box 1 in the fixing bin 2, and arranging an opening matched with the size of the fixing bin on one side of the shell 18 close to the slot of the fixing bin 2 so as to mount and dismount the cooling box 1; be equipped with the locking mechanism that is used for locking and breaking away from the position of cooling box 1 between cooling box 1 and slot 9, locking mechanism includes slider 10, locking piece 11 and rebound and colludes 12, and locking piece 11 sets up on cooling box 1, and slider 10 is along being on a parallel with cooling box 1 pack into orientation and fixed storehouse 2 sliding connection, and rebound colludes 12 one end and slider 10 rotation and be connected, and the other end is towards slot 9 open place one side, is equipped with in fixed storehouse 2 and is used for driving rebound and colludes 12 rotation when slider 10 slides and carry out cooling box 1 locking and the elastic drive subassembly that loosens. Can swiftly carry out the installation and the dismantlement of cooling box 1 through using locking mechanism, be convenient for change, also can make the cooling box break away from fast when cooling mechanism goes wrong, avoid producing the influence to blood.
In order to further simplify the installation difficulty and realize quick installation and disassembly, in a specific embodiment, the elastic driving assembly of the invention comprises a containing groove 13 arranged on the fixed bin 2 and a first reset spring 14 arranged on the sliding block 10, wherein the containing groove 13 is positioned at one side of the rebound hook 12, which is far away from the locking block 11, the first reset spring 14 is positioned at the other side of the rebound hook 12, one end of the first reset spring 14 is fixedly connected with the sliding block 10, the other end of the first reset spring is fixedly connected with the rebound hook 12, when the sliding block 10 drives the rebound hook 12 to move towards the inner side of the slot 9, the rebound hook 12 is separated from the containing groove 13 and rotates towards the side of the locking block 11, the locking block 11 and the cooling box 1 connected with the locking block 11 are limited in the slot 9, the locking block 11 is matched with the sliding block 10 through a wedge-shaped inclined plane, and when the cooling box 1 is installed in the slot 9, the sliding block 10 is pushed to move through the locking block 11, and the rebound hook 12 is automatically driven to rotate to limit the locking block 11.
The fixed bin 2 is provided with the sliding hook 15 for positioning the sliding position of the sliding block 10 and the second reset spring 16 for resetting the sliding block 10, the second reset spring 16 is arranged along the sliding direction parallel to the sliding block 10, one end of the second reset spring 16 is fixedly connected with the sliding block 10, the other end of the second reset spring 16 is fixedly connected with the inner wall of the fixed bin 2, the sliding hook 15 is positioned at the other side of the sliding block 10 relative to the second reset spring 16, the sliding block 10 is positioned in place after sliding, the position of the sliding block 10 is limited through the sliding hook 15, automatic control of installation and ejection is realized, the sliding block 10 is convenient for personnel to operate, the surface of the sliding block 10 is opened in the special-shaped groove 17, the special-shaped groove 17 is provided with a concave area for being matched with the end part of the sliding hook 15, when the sliding block 10 slides, the end part of the sliding hook 15 is clamped in the concave area after the sliding block 10 slides in place, and the position of the sliding block 10 is fixed.
The present invention also discloses an extracorporeal circulation system having the blood cooling device described above, comprising an arterial side blood circuit 19, a filter 20, a venous side blood circuit 21, a waste liquid circuit 22, a substitution liquid circuit 23, and a dialysate circuit 24, wherein the blood cooling device is provided in the venous side blood circuit 21 of the extracorporeal circulation system, and a temperature measuring structure is provided in a blood inlet/outlet of the blood cooling device to detect the temperature.
The invention also provides a blood cooling method, which uses the blood cooling device, detects the temperature of the blood at the inlet and outlet of the blood cooling device through a temperature measuring structure, adjusts the distance between the cooling bin 3 and the cooling box 1 according to the cooling requirement, and keeps the outlet blood temperature of the blood cooling device to meet the requirement; when the supercooling phenomenon occurs, the cooling box 1 is directly ejected from the fixed bin 2; the process of adjusting the distance between the cooling bin 3 and the cooling box 1 comprises the following steps: the linear driving mechanism 5 is started, the guide block 4 is driven to horizontally move through the linear driving mechanism 5, when the guide block 4 moves, acting force is applied to the guide column 7 through the guide groove 6, the guide column 7 is driven to move along the inclined direction of the guide groove 6, and the guide column 7 is driven to drive the cooling bin 3 to be close to or far away from the cooling box 1 by changing the moving direction of the guide block 4.
The process of ejecting the cooling box 1 from the fixed bin 2 includes: the cooling box 1 is pressed into the slot 9, the end part of the sliding hook 15 is separated from the concave area of the special-shaped groove 17, so that the sliding hook 15 is rotated, the sliding block 10 can be separated from the sliding hook 15, the sliding block 10 is driven to reset under the action of the pulling force of the second reset spring 16, the cooling box 1 is pushed to move out of the fixed bin 2 through the wedge-shaped inclined plane matched with the locking block 11 in the resetting process of the sliding block 10, the rebound hook 12 moves synchronously with the sliding block 10, and after moving to the accommodating groove 13, the rebound hook 12 rotates into the accommodating groove 13 under the action of the pushing force of the first reset spring 14, and the cooling box 1 is taken out of the fixed bin 2.
The foregoing is only a preferred embodiment of the invention, it being noted that: it will be apparent to those skilled in the art that various modifications and adaptations can be made without departing from the principles of the present invention, and such modifications and adaptations are intended to be comprehended within the scope of the invention.
Claims (12)
1. The blood cooling device is characterized by comprising a cooling mechanism and a cooling box (1) for heat exchange between a blood flow and the cooling mechanism, wherein the cooling box (1) is detachably arranged in a fixed bin (2); the cooling mechanism comprises a cooling bin (3) with refrigerating fluid inside and a cooling component for cooling the cooling bin (3), wherein one side of the cooling bin (3) deviating from the cooling box (1) is provided with an adjusting mechanism for driving the cooling bin (3) to be close to or far away from the cooling box (1).
2. A blood cooling device according to claim 1, characterized in that the adjusting mechanism comprises a guide block (4) arranged along the surface parallel to the cooling bin (3), a linear driving mechanism (5) driving the guide block (4) to move along the direction parallel to the cooling bin (3) and a driving component used for being matched with the guide block (4) to convert the linear movement of the guide block (4) into the movement perpendicular to the direction of the cooling bin (3), the driving component is connected with the cooling bin (3), and the guide block (4) is used for driving the cooling bin (3) to be close to or far away from the cooling box (1) when sliding.
3. A blood cooling device according to claim 2, characterized in that the driving assembly comprises a guide groove (6) arranged in the guide block (4), the guide groove (6) is obliquely arranged in the guide block (4) along the direction towards the cooling bin (3), a guide column (7) matched with the groove width of the guide groove (6) is arranged in the guide groove (6) in a penetrating way, the end part of the guide column (7) is fixedly connected with the cooling bin (3), and a limiting U-shaped frame (8) used for limiting the two sides of the cooling bin (3) perpendicular to the moving direction is arranged on the outer side of the cooling bin (3).
4. The blood cooling device according to claim 1, wherein a slot (9) used for accommodating the cooling box (1) is arranged in the fixed bin (2), a locking mechanism used for locking and unlocking the position of the cooling box (1) is arranged between the cooling box (1) and the slot (9), the locking mechanism comprises a sliding block (10), a locking block (11) and a rebound hook (12), the locking block (11) is arranged on the cooling box (1), the sliding block (10) is in sliding connection with the fixed bin (2) along the accommodating direction parallel to the cooling box (1), one end of the rebound hook (12) is rotationally connected with the sliding block (10), the other end faces one side of the opening of the slot (9), and an elastic driving assembly used for driving the rebound hook (12) to rotate for locking and unlocking the cooling box (1) when the sliding block (10) slides is arranged in the fixed bin (2).
5. The blood cooling device according to claim 4, wherein the elastic driving assembly comprises a containing groove (13) arranged on the fixed bin (2) and a first return spring (14) arranged on the sliding block (10), the containing groove (13) is located at one side of the rebound hook (12) deviating from the locking block (11), the first return spring (14) is located at the other side of the rebound hook (12), one end of the first return spring (14) is fixedly connected with the sliding block (10), the other end of the first return spring is fixedly connected with the rebound hook (12), and when the sliding block (10) drives the rebound hook (12) to move towards the inner side of the slot (9), the rebound hook (12) is separated from the containing groove (13) and rotates towards one side where the locking block (11) is located, so that the locking block (11) and the cooling box (1) connected with the locking block (11) are limited in the slot (9).
6. The blood cooling device according to claim 5, wherein the fixed bin (2) is provided with a sliding hook (15) for positioning the sliding position of the sliding block (10) and a second return spring (16) for resetting the sliding block (10), the second return spring (16) is arranged along a sliding direction parallel to the sliding block (10), one end of the second return spring (16) is fixedly connected with the sliding block (10), the other end of the second return spring is fixedly connected with the inner wall of the fixed bin (2), the sliding hook (15) is positioned on the other side of the sliding block (10) relative to the second return spring (16), and the position of the sliding block (10) is limited by the sliding hook (15) after the sliding block (10) slides in place.
7. The blood cooling device according to claim 6, wherein the surface of the sliding block (10) is provided with a special-shaped groove (17), the special-shaped groove (17) is provided with a concave area for being matched with the end part of the sliding hook (15), and when the sliding block (10) slides, the sliding hook (15) enters the concave area of the special-shaped groove (17) from the end part of the sliding block (10).
8. The blood cooling device according to claim 5, wherein the locking block (11) is matched with the sliding block (10) through a wedge-shaped inclined plane, and when the cooling box (1) is installed in the slot (9), the sliding block (10) is pushed to move through the locking block (11), and the rebound hook (12) is automatically driven to rotate to limit the locking block (11).
9. The blood cooling device according to claim 1, wherein the number of the cooling mechanisms is two, the cooling mechanisms are symmetrically arranged on two sides of the fixed bin (2), the cooling boxes (1) are synchronously cooled, and the number of the adjusting mechanisms is matched with the number of the cooling mechanisms.
10. An extracorporeal circulation system having the blood cooling device according to any one of claims 1 to 9, wherein the blood cooling device is provided on a venous side blood circuit (21) of the extracorporeal circulation system, and a temperature measuring structure is provided at a blood inlet and outlet of the blood cooling device for temperature detection.
11. A blood cooling method, using the blood cooling device according to claims 1-9, characterized in that the temperature of the blood at the inlet and outlet of the blood cooling device is detected by a temperature measuring structure, and the distance between the cooling bin (3) and the cooling box (1) is adjusted according to the cooling requirement, so as to keep the outlet blood temperature of the blood cooling device to meet the requirement; when the supercooling phenomenon occurs, the cooling box (1) is directly ejected from the fixed bin (2); the process for adjusting the distance between the cooling bin (3) and the cooling box (1) comprises the following steps: starting the linear driving mechanism (5), driving the guide block (4) to move horizontally through the linear driving mechanism (5), applying acting force to the guide column (7) through the guide groove (6) when the guide block (4) moves, driving the guide column (7) to move along the inclined direction of the guide groove (6), and driving the guide column (7) to drive the cooling bin (3) to be close to or far away from the cooling box (1) through changing the moving direction of the guide block (4).
12. A blood cooling method according to claim 11, wherein ejecting the cooling cartridge (1) from the fixed compartment (2) comprises: loosening the slip of locking sliding block (10) and colludeing (15), under the pulling force effect of second reset spring (16), drive sliding block (10) and reset, at sliding block (10) in-process that resets, through with locking piece (11) complex wedge inclined plane promotion cooling box (1) to fixed storehouse (2) outside remove, rebound collude (12) and remove along with sliding block (10) synchronization, after removing holding tank (13), under the thrust effect of first reset spring (14), rebound collude (12) rotate get into holding tank (13) in, take out cooling box (1) from in fixed storehouse (2).
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