CN117618522A - Composition for adjuvant therapy of liver cancer and preparation method and application thereof - Google Patents

Abstract

The application relates to the technical field of medicines, in particular to a composition for assisting in treating liver cancer, and a preparation method and application thereof. The composition is prepared from the following components in parts by weight: 100 parts of honeysuckle, 100 parts of dandelion, 350 parts of bupleurum, 350 parts of curcuma zedoary, 100 parts of astragalus, 100 parts of ginseng, 100 parts of mulberry, 100 parts of glossy privet fruit, 350 parts of ligusticum wallichii and 14 parts of spirulina. The medicine for adjuvant therapy of liver cancer provided by the embodiment of the application has the effects of activating blood circulation to remove blood stasis, promoting qi circulation and relieving pain, and is used for adjuvant therapy of liver cancer with the syndrome of qi stagnation and blood stasis.

Description

Composition for adjuvant therapy of liver cancer and preparation method and application thereof

Technical Field

The application belongs to the technical field of medicines, and particularly relates to a composition for assisting in treating liver cancer, and a preparation method and application thereof.

Background

Aiming at the pathogenesis characteristics of deficiency and excess and impurity with deficiency of qi and blood and accumulation of qi and blood damp-heat and toxin as the principal and secondary aspect of the disease of liver cancer patients, the liver cancer patients can strengthen the body resistance to eliminate pathogenic factors and treat both principal and secondary aspect of the disease to restore the function of liver to dredge, so that qi and blood run smoothly, and pathogenic factors of damp-heat and toxin have routes, thereby relieving and alleviating the illness state. However, the traditional Chinese medicine variety is not ideal in treatment effect and pain relieving effect. Therefore, secondary development research is required to be carried out on the traditional Chinese medicine compound, and a new formulation or a new preparation process is selected to improve the treatment effect of the traditional Chinese medicine compound.

Disclosure of Invention

The application aims to provide a composition for assisting in treating liver cancer, a preparation method and application thereof, and the composition is used for assisting in treating liver cancer with the syndrome of qi stagnation and blood stasis.

In order to achieve the purposes of the application, the technical scheme adopted by the application is as follows:

in a first aspect, an embodiment of the present application provides a composition for adjuvant therapy of liver cancer, which is prepared from the following components in parts by weight:

100 parts of honeysuckle, 100 parts of dandelion, 350 parts of bupleurum, 350 parts of curcuma zedoary, 100 parts of astragalus, 100 parts of ginseng, 100 parts of mulberry, 100 parts of glossy privet fruit, 350 parts of ligusticum wallichii and 14 parts of spirulina.

In a second aspect, embodiments of the present application provide an application of the above composition in preparing a medicament for assisting in treating liver cancer, wherein the medicament includes the composition, starch and talcum powder.

Optionally, the medicament is a capsule.

In a third aspect, an embodiment of the present application provides a method for preparing a drug for adjuvant therapy of liver cancer, including the following steps:

providing the components of the above composition;

decocting flos Lonicerae, herba Taraxaci, bupleuri radix, curcumae rhizoma, radix astragali, ginseng radix, mori fructus, fructus Ligustri Lucidi, rhizoma Ligustici Chuanxiong and 8 times of water twice for 1.5 hr each time;

mixing the two decoctions, filtering, concentrating the filtrate under reduced pressure to obtain fluid extract with relative density of 1.05-1.10, and maintaining the operation temperature at 60deg.C;

then drying and spraying to obtain dry paste powder;

adding spirulina into the dry extract powder, and adding starch and pulvis Talci to obtain the final product.

Compared with the prior art, the beneficial effects of the embodiment of the application are as follows:

the medicine for adjuvant therapy of liver cancer provided by the embodiment of the application has the effects of activating blood circulation to remove blood stasis, promoting qi circulation and relieving pain, and is used for adjuvant therapy of liver cancer with the syndrome of qi stagnation and blood stasis.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present application, the following description will briefly introduce the drawings that are needed in the embodiments or the description of the prior art, it is obvious that the drawings in the following description are only some embodiments of the present application, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.

Fig. 1 is a flow chart of a method for preparing a drug for assisting in treating liver cancer according to an embodiment of the present application.

Detailed Description

In order to make the technical problems, technical schemes and beneficial effects to be solved by the present application more clear, the present application is further described in detail below with reference to the embodiments. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the present application.

The embodiment of the application provides a composition for assisting in treating liver cancer, which is prepared from the following components in parts by weight: 100 parts of honeysuckle, 100 parts of dandelion, 350 parts of bupleurum, 350 parts of curcuma zedoary, 100 parts of astragalus, 100 parts of ginseng, 100 parts of mulberry, 100 parts of glossy privet fruit, 350 parts of ligusticum wallichii and 14 parts of spirulina.

The composition provided by the embodiment of the application has the effects of activating blood circulation to remove blood stasis, promoting qi circulation and relieving pain, and is used for the adjuvant therapy of liver cancer with the syndrome of qi stagnation and blood stasis.

In some embodiments, there is also provided the use of the above composition for the manufacture of a medicament for the adjuvant treatment of liver cancer, for example a medicament comprising the composition together with an amount of starch and an amount of talc. Optionally, the medicament is in the form of a capsule.

In some embodiments of the present application, the composition for adjunctive treatment of liver cancer is made from the following components by weight: 100g of honeysuckle, 100g of dandelion, 350g of bupleurum, 350g of curcuma zedoary, 100g of astragalus, 100g of ginseng, 100g of mulberry, 100g of glossy privet fruit, 350g of ligusticum wallichii and 14g of spirulina. The medicine for assisting in treating liver cancer comprises the composition, a proper amount of starch and a proper amount of talcum powder.

For example, as shown in fig. 1, the preparation method of the drug for adjuvant therapy of liver cancer comprises the following steps:

s110, providing the components of the composition of any of the embodiments above.

For example, the composition is made from the following components by weight: 100g of honeysuckle, 100g of dandelion, 350g of bupleurum, 350g of curcuma zedoary, 100g of astragalus, 100g of ginseng, 100g of mulberry, 100g of glossy privet fruit, 350g of ligusticum wallichii and 14g of spirulina.

S120, decocting flos Lonicerae, herba Taraxaci, bupleuri radix, curcumae rhizoma, radix astragali, ginseng radix, mori fructus, fructus Ligustri Lucidi, and rhizoma Ligustici Chuanxiong with 8 times of water twice for 1.5 hr each time.

S130, combining the two decoctions, filtering, concentrating the filtrate under reduced pressure to obtain fluid extract with the relative density of 1.05-1.10, and maintaining the operation temperature at 60 ℃.

S140, drying and spraying to obtain dry paste powder.

S150, adding spirulina into the dry paste powder to obtain the composition, and adding a proper amount of starch and a proper amount of talcum powder to prepare the medicine. For example, 1000 capsules (0.4 g per capsule) are prepared.

The composition and the medicine for adjuvant therapy of liver cancer provided by the embodiment of the application have the effects of activating blood circulation to remove blood stasis and promoting qi circulation to relieve pain, and are used for adjuvant therapy of liver cancer with the syndrome of qi stagnation and blood stasis.

The following description is made with reference to specific embodiments.

Example 1: the first medicine for assisting in treating liver cancer is prepared from the following components in parts by weight by adopting the preparation method:

example 2: the second drug for assisting in treating liver cancer is prepared from the following components in parts by weight:

example 3: the third drug for assisting in treating liver cancer is prepared from the following components in parts by weight:

example 4: the fourth drug for assisting in treating liver cancer is prepared from the following components in parts by weight:

the practical application of the medicament for promoting blood circulation, removing blood stasis and promoting qi circulation to relieve pain obtained in the example 1 is that 200 cases are subjected to a comparison test, wherein 100 cases are female and 100 cases are male.

Crowd selection criteria: early liver cancer patients in the convalescence after chemotherapy, chest and hypochondrium distension and fullness, irregular menstruation, menstrual abdominal pain, dark purple menstruation, breast distending pain and other symptoms. One week prior to the experiment, the population was continuously observed, changes in symptoms were recorded, and the population was randomly divided into two groups, an experimental group and a control group.

The experimental group took the first drug for the adjuvant treatment of liver cancer of example 1, and the control group took at least one of the above second drug for the adjuvant treatment of liver cancer, the third drug for the adjuvant treatment of liver cancer and the fourth drug for the adjuvant treatment of liver cancer.

Curative effect condition judgment standard:

effectively, after taking the product, the chest and hypochondrium distension and fullness are relieved, the mood is smooth, the lump is reduced and disappears, the abdominal pain is relieved and disappears, the menstrual color is normal, the breast distending pain is relieved, and the peripheral turn around the liver swelling is not enlarged.

Invalidation: after taking the product, the effect is not obvious without obvious change. The results are shown in Table one below:

list one

	Experimental group	Control group
			Number of examples	100	100
Male men	50	50
			Female woman	50	50
Number of effective cases	98	71
			Number of invalid cases	2	29
Effective rate of	98％	71％

The treatment effect is as follows: from the above results, it is evident that the medicine for adjuvant therapy of liver cancer provided by the embodiments of the present application is significantly superior to other formulations in the adjuvant therapy of liver cancer patients with syndrome of qi stagnation and blood stasis and the liver cancer caused by the syndrome.

It should be understood that, in various embodiments of the present application, the sequence number of each process does not mean that the sequence of execution is sequential, and some or all of the steps may be executed in parallel or sequentially, where the execution sequence of each process should be determined by its functions and internal logic, and should not constitute any limitation on the implementation process of the embodiments of the present application.

The terminology used in the embodiments of the application is for the purpose of describing particular embodiments only and is not intended to be limiting of the application. As used in this application and the appended claims, the singular forms "a," "an," and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise.

The weights of the relevant components mentioned in the embodiments of the present application may refer not only to specific contents of the components, but also to the proportional relationship between the weights of the components, and thus, any ratio of the contents of the relevant components according to the embodiments of the present application may be enlarged or reduced within the scope disclosed in the embodiments of the present application. Specifically, the mass described in the specification of the examples of the present application may be a mass unit known in the chemical industry such as μ g, mg, g, kg.

The foregoing description of the preferred embodiments of the present application is not intended to be limiting, but is intended to cover any and all modifications, equivalents, and alternatives falling within the spirit and principles of the present application.

Claims (4)

1. The composition for assisting in treating liver cancer is characterized by being prepared from the following components in parts by weight:

100 parts of honeysuckle, 100 parts of dandelion, 350 parts of bupleurum, 350 parts of curcuma zedoary, 100 parts of astragalus, 100 parts of ginseng, 100 parts of mulberry, 100 parts of glossy privet fruit, 350 parts of ligusticum wallichii and 14 parts of spirulina.

2. The use of a composition according to claim 1 for the preparation of a medicament for the adjuvant treatment of liver cancer, wherein the medicament comprises the composition together with starch and talc.

3. The use according to claim 2, wherein the medicament is in the form of a capsule.

4. The preparation method of the drug for assisting in treating liver cancer is characterized by comprising the following steps:

providing the components of the composition of claim 1;

decocting flos Lonicerae, herba Taraxaci, bupleuri radix, curcumae rhizoma, radix astragali, ginseng radix, mori fructus, fructus Ligustri Lucidi, rhizoma Ligustici Chuanxiong and 8 times of water twice for 1.5 hr each time;

mixing the two decoctions, filtering, concentrating the filtrate under reduced pressure to obtain fluid extract with relative density of 1.05-1.10, and maintaining the operation temperature at 60deg.C;

then drying and spraying to obtain dry paste powder;

adding the spirulina into the dry paste powder, and adding starch and talcum powder to prepare the medicine.