CN1175876C

CN1175876C - Antineoplastic Chinese medicine

Info

Publication number: CN1175876C
Application number: CNB02135300XA
Authority: CN
Inventors: 顾谦群; 方玉春; 辛现良; 张向农; 管华诗
Original assignee: Ocean University of Oingdao
Current assignee: Ocean University of Oingdao
Priority date: 2002-08-02
Filing date: 2002-08-02
Publication date: 2004-11-17
Anticipated expiration: 2022-08-02
Also published as: CN1395960A

Abstract

The present invention relates to an antineoplastic traditional Chinese medicine which is characterized in that the medicine is dispensed by radix astragali seu hedysari, polyporus umbellatus, sargassum, rhizoma atractylodis macrocephalae, radix linderae, endothelium corneae gigeriae galli and herba hedyotidis diffusae in certain weight proportion through advising a theory of the traditional Chinese medicine, combining the foundation of modern chemistry and pharmacology and referring clinical medication experience according to the weight percentage of 50 to 100: 50 to 100: 50 to 100: 50 to 100: 50 to 100: 20 to 50: 20 to 50. Pharmacological experiment in animal bodies shows that the medicine has obvious inhibiting effects on S180 tumors and ehrlich ascites tumors of mice, and immune functions of tumor bearing mice can be obviously enhanced. The medicine of the present invention has the advantages of obvious tumor inhibition effects, low toxic and side effects and good effects on the clinical coordination of radiotherapy and chemotherapy for curing lung cancer and digestive tract cancer.

Description

A kind of antineoplastic Chinese medicine

Technical field

The present invention relates to a kind of Chinese medicine, particularly relate to a kind of anti-tumor compound Chinese medicine.

Background technology

Malignant tumor is the disease of serious harm human health, existing antitumor drug mostly is cytotoxic drug greatly, such medicine is in killing tumor cell, the human normal cell also there is infringement, serious destruction immunity of organism organ, make tumor patient quality of life low, increase in life span descends.China's Chinese medicine has long clinical application basis, press down aspects such as tumor, immunostimulant in treating the poisonous disease with poisonous drugs, immunity and developed many PTS, but most tumor killing effect is not good.

Summary of the invention

The purpose of this invention is to provide a kind of effective tumor suppression medicine, it can remedy the above-mentioned deficiency of existing medicine.

A kind of antineoplastic Chinese medicine, the effective ingredient that it is characterized in that it is made by following raw materials according: the Radix Astragali, Polyporus, the Rhizoma Atractylodis Macrocephalae, Sargassum, the Radix Linderae, Endothelium Corneum Gigeriae Galli, Herba Hedyotidis Diffusae, the ratio of their parts by weight is: 50-100: 50-100: 50-100: 50-100: 50-100: 20-50: 20-50.

Above-mentioned antitumor preparation method of Chinese medicine, it is characterized in that each raw material of Chinese medicine is ground into coarse powder, 60 ℃ of-80 ℃ of water-baths of diluted acid water with 8-12 times of weight are extracted, filter, 60 ℃ of-80 ℃ of water-baths of the diluted alkaline water of 8-12 times of weight of medicinal residues reuse are extracted, merge the soda acid extracting solution, concentrating under reduced pressure adds adjuvant and makes granule.

Process for preparing medicine of the present invention is simple to operate, the cycle is short, active constituent content is high, and cost of manufacture is low; This medicine can significantly improve body's immunity, obviously improves the life quality of tumour patient.

The specific embodiment

Below by embodiment the present invention is described.

Take by weighing Radix Astragali 75g, Polyporus 75g, Rhizoma Atractylodis Macrocephalae 75g, Sargassum 75g, Radix Linderae 75g, Endothelium Corneum Gigeriae Galli 35g, Herba Hedyotidis Diffusae 35g, it is coarse powder (20-80 order) that each Chinese medicine component is pulverized, 80 ℃ of water-baths of diluted acid water (pH2-4) with 10 times of weight are extracted twice, filter, 80 ℃ of water-baths of the diluted alkaline water (pH7.5-9.5) of 8-12 times of weight of medicinal residues reuse are extracted twice, merge the soda acid extracting solution, concentrating under reduced pressure, adding dextrin, Icing Sugar excipient are made granule.The preparation of making is an index with the content of active ingredient astragaloside and total polysaccharides, adopts high performance liquid chromatogram and phenolsulfuric acid method to carry out quality control standard.

Chinese medicine of the present invention is formed by the principle of Chinese traditional treatment tumor.Radix Astragali tonifying Qi and lifting yang wherein has tonification castering action preferably for the deficiency of vital energy of spleen lung, stops the poly-merit that inducing diuresis to remove edema can be arranged because of insufficiency of the spleen fortune water is wet; But the Rhizoma Atractylodis Macrocephalae is air making-up and spleen enlivening, dampness, diuretic also, for this reason Fang monarch drug.Sargassum is salty-cold, antiinflammatory softening the hard mass, broken eliminating stagnation gas; Polyporus diuresis, eliminating dampness by diuresis, that expectorant is given birth to is passive, for this reason Fang ministerial drug.The Herba Hedyotidis Diffusae heat-clearing and toxic substances removing, promoting blood circulation and stopping pain can be separated expectorant blood coagulation stasis of blood poison and accumulate, and the merit of inducing diuresis to remove edema is arranged, for this reason Fang adjuvant drug.The Endothelium Corneum Gigeriae Galli activating the spleen helps digestion, in case stagnation of dampness due to deficiency of the spleen, and failing of the spleen to transport and cause dyspepsia; The hot Wen Xiang of the Radix Linderae scurries, on walk the spleen lung, the reason breast abdomen stagnation of QI, promoting the circulation of QI to relieve pain are assigned kidney and bladder, warming kidney for dispelling cold, sensible yang-energy so that part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels water channel is unobstructed, has both helped absorption, the running of medicine, the anti-again sweet stagnant cold of all medicines is cold, for this reason Fang messenger drug.

In sum, the Radix Astragali is mended the gas of strengthening spleen and lung, and invigorating spleen to remove dampness, the Rhizoma Atractylodis Macrocephalae help its power; The Sargassum eliminating phlegm and softening indurated mass, broken eliminating stagnation gas, Polyporus is strengthened its usefulness; The Herba Hedyotidis Diffusae heat-clearing and toxic substances removing, promoting blood circulation and stopping pain; Endothelium Corneum Gigeriae Galli, the Radix Linderae are transferred sharp taste, and sensible yang-energy had both helped the absorptions running of medicine, and the anti-again sweet stagnant cold of all medicines is cold, and the group medicine of full side is auxilliary mutually to be usefulness, focus on QI invigorating, spleen invigorating, reduce phlegm, eliminating stagnation.

Medicine of the present invention has QI invigorating, spleen invigorating, reduces phlegm, the eliminating stagnation effect, by the pharmacodynamics requirement of the anticancer centralizing function of Chinese medicine, is that model has been observed inhibition and the life prolongation effect of said preparation to tumor growth with mice S180 solid tumor, mice Emhorn ascitic type tumor; And observe its influence to tumor-bearing mice spleen antibody-producting cell, Turnover of Mouse Peritoneal Macrophages phagocytic function and tumor-bearing mice thymus, spleen weight.The result shows: said preparation can significantly suppress the growth of mice S180 solid tumor, prolongs ascitic type mice with tumor life span; And obviously increase the weight of tumor-bearing mice immune organ, and improve the Turnover of Mouse Peritoneal Macrophages phagocytic function, promote the generation of tumor-bearing mice spleen antibody-producting cell simultaneously.

Clinical drug of the present invention cooperates radiotherapy or chemotherapy according to different sick sensitivity and different situations of planting radiotherapy, chemotherapy, and one month is a course of treatment.Put, still can continue to take behind the end of chemotherapy, generally take 2-6 the course of treatment.Treat 20 examples altogether, pulmonary carcinoma 5 examples wherein, human primary gastrointestinal cancers 15 examples, effective percentage is pressed the CR+PR statistics, and life quality is pressed Ka Shi scoring statistics, and curative effect and life quality analysis all are higher than the radiation alone and the chemotherapy group of general bibliographical information, experimental results show that this side has tumour inhibiting rate preferably, there is no obvious toxic and side effects.

Claims

1. antineoplastic Chinese medicine, the effective ingredient that it is characterized in that it is made by following raw materials according: the Radix Astragali, Polyporus, the Rhizoma Atractylodis Macrocephalae, Sargassum, the Radix Linderae, Endothelium Corneum Gigeriae Galli, Herba Hedyotidis Diffusae, the ratio of their parts by weight is: 50-100: 50-100: 50-100: 50-100: 50-100: 20-50: 20-50.

2. antitumor preparation method of Chinese medicine according to claim 1, it is characterized in that each raw material of Chinese medicine is ground into coarse powder, 60 ℃ of-80 ℃ of water-baths of diluted acid water with 8-12 times of weight are extracted, filter, 60 ℃ of-80 ℃ of water-baths of the diluted alkaline water of 8-12 times of weight of medicinal residues reuse are extracted, merge the soda acid extracting solution, concentrating under reduced pressure adds adjuvant and makes granule.