CN117582333A - Hot compress pack containing volcanic rock and preparation method thereof - Google Patents
Hot compress pack containing volcanic rock and preparation method thereof Download PDFInfo
- Publication number
- CN117582333A CN117582333A CN202410064432.2A CN202410064432A CN117582333A CN 117582333 A CN117582333 A CN 117582333A CN 202410064432 A CN202410064432 A CN 202410064432A CN 117582333 A CN117582333 A CN 117582333A
- Authority
- CN
- China
- Prior art keywords
- drying
- solution
- deionized water
- volcanic rock
- washing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 60
- 239000011435 rock Substances 0.000 title claims abstract description 54
- 241000411851 herbal medicine Species 0.000 claims abstract description 33
- 239000004745 nonwoven fabric Substances 0.000 claims abstract description 20
- OILXMJHPFNGGTO-UHFFFAOYSA-N (22E)-(24xi)-24-methylcholesta-5,22-dien-3beta-ol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(C)C(C)C)C1(C)CC2 OILXMJHPFNGGTO-UHFFFAOYSA-N 0.000 claims abstract description 16
- OQMZNAMGEHIHNN-UHFFFAOYSA-N 7-Dehydrostigmasterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CC(CC)C(C)C)CCC33)C)C3=CC=C21 OQMZNAMGEHIHNN-UHFFFAOYSA-N 0.000 claims abstract description 16
- HZYXFRGVBOPPNZ-UHFFFAOYSA-N UNPD88870 Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)=CCC(CC)C(C)C)C1(C)CC2 HZYXFRGVBOPPNZ-UHFFFAOYSA-N 0.000 claims abstract description 16
- LGJMUZUPVCAVPU-UHFFFAOYSA-N beta-Sitostanol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(CC)C(C)C)C1(C)CC2 LGJMUZUPVCAVPU-UHFFFAOYSA-N 0.000 claims abstract description 16
- HCXVJBMSMIARIN-PHZDYDNGSA-N stigmasterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)/C=C/[C@@H](CC)C(C)C)[C@@]1(C)CC2 HCXVJBMSMIARIN-PHZDYDNGSA-N 0.000 claims abstract description 16
- 229940032091 stigmasterol Drugs 0.000 claims abstract description 16
- BFDNMXAIBMJLBB-UHFFFAOYSA-N stigmasterol Natural products CCC(C=CC(C)C1CCCC2C3CC=C4CC(O)CCC4(C)C3CCC12C)C(C)C BFDNMXAIBMJLBB-UHFFFAOYSA-N 0.000 claims abstract description 16
- 235000016831 stigmasterol Nutrition 0.000 claims abstract description 16
- 239000000463 material Substances 0.000 claims abstract description 7
- 239000013543 active substance Substances 0.000 claims abstract description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 109
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 92
- 239000000243 solution Substances 0.000 claims description 84
- 238000001035 drying Methods 0.000 claims description 73
- 239000008367 deionised water Substances 0.000 claims description 71
- 229910021641 deionized water Inorganic materials 0.000 claims description 71
- 238000005406 washing Methods 0.000 claims description 62
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 60
- 239000011575 calcium Substances 0.000 claims description 52
- 238000002156 mixing Methods 0.000 claims description 50
- 238000001914 filtration Methods 0.000 claims description 48
- 239000000203 mixture Substances 0.000 claims description 47
- 238000010438 heat treatment Methods 0.000 claims description 40
- 238000003756 stirring Methods 0.000 claims description 40
- 238000007873 sieving Methods 0.000 claims description 38
- 239000011259 mixed solution Substances 0.000 claims description 37
- 239000000843 powder Substances 0.000 claims description 36
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 35
- 235000019441 ethanol Nutrition 0.000 claims description 33
- 239000002244 precipitate Substances 0.000 claims description 32
- 238000001816 cooling Methods 0.000 claims description 28
- 239000000047 product Substances 0.000 claims description 28
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 25
- 241001474374 Blennius Species 0.000 claims description 24
- 239000012867 bioactive agent Substances 0.000 claims description 21
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 claims description 20
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 20
- 238000002791 soaking Methods 0.000 claims description 19
- 229940068918 polyethylene glycol 400 Drugs 0.000 claims description 15
- 239000007788 liquid Substances 0.000 claims description 14
- 238000000498 ball milling Methods 0.000 claims description 12
- 238000006243 chemical reaction Methods 0.000 claims description 12
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims description 12
- 239000000706 filtrate Substances 0.000 claims description 12
- 239000008055 phosphate buffer solution Substances 0.000 claims description 12
- 238000010298 pulverizing process Methods 0.000 claims description 12
- SPOMEWBVWWDQBC-UHFFFAOYSA-K tripotassium;dihydrogen phosphate;hydrogen phosphate Chemical compound [K+].[K+].[K+].OP(O)([O-])=O.OP([O-])([O-])=O SPOMEWBVWWDQBC-UHFFFAOYSA-K 0.000 claims description 12
- 229910021642 ultra pure water Inorganic materials 0.000 claims description 12
- 239000012498 ultrapure water Substances 0.000 claims description 12
- 241000196252 Ulva Species 0.000 claims description 11
- 238000000227 grinding Methods 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 11
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims description 10
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 10
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 10
- 239000004343 Calcium peroxide Substances 0.000 claims description 10
- 108010059892 Cellulase Proteins 0.000 claims description 10
- 108010010803 Gelatin Proteins 0.000 claims description 10
- 238000001354 calcination Methods 0.000 claims description 10
- LHJQIRIGXXHNLA-UHFFFAOYSA-N calcium peroxide Chemical compound [Ca+2].[O-][O-] LHJQIRIGXXHNLA-UHFFFAOYSA-N 0.000 claims description 10
- 235000019402 calcium peroxide Nutrition 0.000 claims description 10
- 229940106157 cellulase Drugs 0.000 claims description 10
- 239000012153 distilled water Substances 0.000 claims description 10
- 229920000159 gelatin Polymers 0.000 claims description 10
- 239000008273 gelatin Substances 0.000 claims description 10
- 235000019322 gelatine Nutrition 0.000 claims description 10
- 235000011852 gelatine desserts Nutrition 0.000 claims description 10
- 239000002245 particle Substances 0.000 claims description 10
- 239000007974 sodium acetate buffer Substances 0.000 claims description 10
- BHZOKUMUHVTPBX-UHFFFAOYSA-M sodium acetic acid acetate Chemical compound [Na+].CC(O)=O.CC([O-])=O BHZOKUMUHVTPBX-UHFFFAOYSA-M 0.000 claims description 10
- 239000011780 sodium chloride Substances 0.000 claims description 10
- 230000001105 regulatory effect Effects 0.000 claims description 8
- 230000001954 sterilising effect Effects 0.000 claims description 8
- 238000004659 sterilization and disinfection Methods 0.000 claims description 8
- 230000007480 spreading Effects 0.000 claims description 7
- 238000003892 spreading Methods 0.000 claims description 7
- 241000512259 Ascophyllum nodosum Species 0.000 claims description 6
- 241000195474 Sargassum Species 0.000 claims description 6
- 239000002253 acid Substances 0.000 claims description 6
- 238000000605 extraction Methods 0.000 claims description 6
- 238000000874 microwave-assisted extraction Methods 0.000 claims description 6
- 238000010992 reflux Methods 0.000 claims description 6
- 238000001694 spray drying Methods 0.000 claims description 6
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 claims description 5
- 229940090248 4-hydroxybenzoic acid Drugs 0.000 claims description 5
- 241001071795 Gentiana Species 0.000 claims description 5
- 229910021578 Iron(III) chloride Inorganic materials 0.000 claims description 5
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 5
- 239000007853 buffer solution Substances 0.000 claims description 5
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 5
- 229930016911 cinnamic acid Natural products 0.000 claims description 5
- 235000013985 cinnamic acid Nutrition 0.000 claims description 5
- 238000004108 freeze drying Methods 0.000 claims description 5
- 239000005457 ice water Substances 0.000 claims description 5
- 239000012535 impurity Substances 0.000 claims description 5
- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 claims description 5
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 claims description 5
- 229910052757 nitrogen Inorganic materials 0.000 claims description 5
- 229910052938 sodium sulfate Inorganic materials 0.000 claims description 5
- 235000011152 sodium sulphate Nutrition 0.000 claims description 5
- 238000009210 therapy by ultrasound Methods 0.000 claims description 5
- XPFJYKARVSSRHE-UHFFFAOYSA-K trisodium;2-hydroxypropane-1,2,3-tricarboxylate;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound [Na+].[Na+].[Na+].OC(=O)CC(O)(C(O)=O)CC(O)=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O XPFJYKARVSSRHE-UHFFFAOYSA-K 0.000 claims description 5
- 238000001291 vacuum drying Methods 0.000 claims description 5
- 238000007789 sealing Methods 0.000 claims description 4
- 238000009958 sewing Methods 0.000 claims description 4
- 238000004026 adhesive bonding Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 24
- 239000004480 active ingredient Substances 0.000 abstract description 14
- 201000010099 disease Diseases 0.000 abstract description 14
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 14
- 230000017531 blood circulation Effects 0.000 abstract description 12
- 230000004054 inflammatory process Effects 0.000 abstract description 11
- 206010061218 Inflammation Diseases 0.000 abstract description 10
- 241000894006 Bacteria Species 0.000 abstract description 8
- 206010013935 Dysmenorrhoea Diseases 0.000 abstract description 8
- 208000005171 Dysmenorrhea Diseases 0.000 abstract description 6
- 238000005485 electric heating Methods 0.000 abstract description 5
- 206010046914 Vaginal infection Diseases 0.000 abstract description 3
- 208000032159 Vaginal inflammation Diseases 0.000 abstract description 2
- 201000008100 Vaginitis Diseases 0.000 abstract description 2
- 230000000052 comparative effect Effects 0.000 description 22
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 10
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 10
- 239000001301 oxygen Substances 0.000 description 10
- 229910052760 oxygen Inorganic materials 0.000 description 10
- 230000006870 function Effects 0.000 description 8
- 239000003814 drug Substances 0.000 description 7
- 208000024891 symptom Diseases 0.000 description 7
- 238000010521 absorption reaction Methods 0.000 description 5
- 239000001569 carbon dioxide Substances 0.000 description 5
- 229910002092 carbon dioxide Inorganic materials 0.000 description 5
- 241000283973 Oryctolagus cuniculus Species 0.000 description 4
- 238000004140 cleaning Methods 0.000 description 4
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- 230000001737 promoting effect Effects 0.000 description 4
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- 210000004291 uterus Anatomy 0.000 description 4
- 208000004926 Bacterial Vaginosis Diseases 0.000 description 3
- 208000037093 Menstruation Disturbances Diseases 0.000 description 3
- 206010027339 Menstruation irregular Diseases 0.000 description 3
- 208000007074 Trichomonas Vaginitis Diseases 0.000 description 3
- 208000025206 Trichomonas vaginitis urogenital infection Diseases 0.000 description 3
- 201000007096 Vulvovaginal Candidiasis Diseases 0.000 description 3
- 230000001580 bacterial effect Effects 0.000 description 3
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- 210000005000 reproductive tract Anatomy 0.000 description 3
- 230000002195 synergetic effect Effects 0.000 description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical class OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- 206010021143 Hypoxia Diseases 0.000 description 2
- 206010040880 Skin irritation Diseases 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
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- 230000004060 metabolic process Effects 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000001850 reproductive effect Effects 0.000 description 2
- 231100000475 skin irritation Toxicity 0.000 description 2
- 230000036556 skin irritation Effects 0.000 description 2
- 230000037303 wrinkles Effects 0.000 description 2
- 206010000084 Abdominal pain lower Diseases 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 206010014733 Endometrial cancer Diseases 0.000 description 1
- 206010014759 Endometrial neoplasm Diseases 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 206010017533 Fungal infection Diseases 0.000 description 1
- 239000005909 Kieselgur Substances 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 206010058679 Skin oedema Diseases 0.000 description 1
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- 206010046798 Uterine leiomyoma Diseases 0.000 description 1
- 206010056530 Vulvovaginal pruritus Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
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- 230000002757 inflammatory effect Effects 0.000 description 1
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- 230000000622 irritating effect Effects 0.000 description 1
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- 244000005700 microbiome Species 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F7/0241—Apparatus for the preparation of hot packs, hot compresses, cooling pads, e.g. heaters or refrigerators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F7/03—Compresses or poultices for effecting heating or cooling thermophore, i.e. self-heating, e.g. using a chemical reaction
- A61F7/032—Compresses or poultices for effecting heating or cooling thermophore, i.e. self-heating, e.g. using a chemical reaction using oxygen from the air, e.g. pocket-stoves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F2007/0203—Cataplasms, poultices or compresses, characterised by their contents; Bags therefor
- A61F2007/0204—Cataplasms, poultices or compresses, characterised by their contents; Bags therefor containing clay, mud, fango, sand, kaolin clay, volcanic or other inorganic granular solids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F2007/0225—Compresses or poultices for effecting heating or cooling connected to the body or a part thereof
- A61F2007/0228—Compresses or poultices for effecting heating or cooling connected to the body or a part thereof with belt or strap, e.g. with buckle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F2007/0261—Compresses or poultices for effecting heating or cooling medicated
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Thermal Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to the technical field of medical care, in particular to a hot compress bag containing volcanic rock and a preparation method thereof, wherein the hot compress bag comprises a box body and a dressing bag, the dressing bag is detachably arranged in the middle of the box body, binding belts are symmetrically arranged on the outer wall of the box body, electric heating plates are arranged in the box body, the dressing bag comprises a bag body and active ingredients arranged in the bag body, the bag body is made of non-woven fabric materials, and the active ingredients comprise the following components in parts by weight: volcanic rock-Ca (OH) 2 90-200 parts of modified diatomite-CaO 2 60-140 parts of Chinese herbal medicine preparation, 30-50 parts of biological active agent, 12-18 parts of stigmasterol and 8-12 parts of stigmasterol. The hot compress bag can maintain microecological balance of female private parts, prevent and treat vaginal infection and inflammation, create warm and dry environment, promote blood circulation, inhibit bacteria and diminish inflammation, have the effects of tightening, relieving skin relaxation, relieving dysmenorrhea, preventing and treating gynecological diseases, and is simple and convenient to use, painless and high-efficiency.
Description
Technical Field
The invention relates to the technical field of medical care, in particular to a hot compress pack containing volcanic rock and a preparation method thereof.
Background
The female pudendum is a main organ for metabolism and secretion, and the vaginal orifice is a portal of two systems of reproduction and urinary, so that the female pudendum is extremely easy to be infected by various diseases, if the female pudendum is not prevented or treated in time, the female body and mind health is affected, and the aging of sexual organs is accelerated; the uterus has the functions of menstruation, fertility and endocrine, is an important reproductive organ for females, can delay the arrival of female menopause, can keep the endocrine function of ovaries normal for a long time, can prevent and reduce the possibility of suffering from inflammatory diseases of reproductive systems, can reduce the incidence rate of neoplastic diseases of uterine parts such as hysteromyoma, endometrial cancer and the like, and is very important for female health. In gynecological diseases, various common diseases and frequently encountered diseases such as inflammation, vaginal itching and the like are basically related to bacterial infection, fungal infection and the like, dysmenorrheal infection and irregular menstruation are related to cold uterus and unsmooth blood flow, so bacteria inhibition and inflammation diminishing are realized, blood circulation is promoted, the female pudendum and uterus health is maintained, the focus of gynecological diseases is reduced, a specific external care product is commonly used at present, cleaning, sterilization and moistening care are carried out on the pudendum, the existing external care product for women is mainly divided into medicinal washing liquid with disease treatment function or female pudendum care product with cleaning and sterilization functions, and the two types of prior care products cannot have drug effect and cleaning and sterilization effects, can destroy flora balance and has skin irritation. The hot compress can promote blood circulation, improve metabolism, and be matched with medicine for use, the heat is favorable for medicine absorption, the blood circulation at the compress position is quickened, and the medicine effect is promoted. The common hot compress mode is to use heat carrier such as hot-water bag, hot towel to carry out the hot compress, convenient to use, with low costs, but the heat dissipation is fast, the hot compress time is short, the hot compress effect is poor, electric hot compress sustainable heating, the hot compress effect is good, but use cost is higher, and must connect the electricity, and the use is restricted. Based on the above, how to develop a hot compress pack which can inhibit bacteria and diminish inflammation, maintain female pudendum microecological balance, is mild and does not irritate, can effectively promote blood circulation, treat and prevent gynecological diseases, and has spontaneous heating and long heating time is a technical problem to be solved.
Disclosure of Invention
Aiming at the technical problems, the invention provides a hot compress pack containing volcanic rock and a preparation method thereof. The invention combines volcanic rock and Ca (OH) 2 Preparation into volcanic rock-Ca (OH) 2 The carbon dioxide can be adsorbed, the heat is released, the heat loss is less, the heat release effect is good, the time is long, the good heat accumulation and temperature rise functions are realized, and the self-heating can be sustained; the modified diatomite-CaO prepared by the invention 2 Oxygen can be slowly released, the water utilization rate is high, the oxygen release amount is large, the female pudendum is kept clean and dry, and bacterial breeding is reduced; the Chinese herbal medicine preparation contains various active ingredients, is easy to be absorbed by human body, and is mild and not irritative; the inventionThe biological active agent is also prepared, so that the microecology balance of the female genital tract can be maintained, and the acid-base balance of the genital tract can be regulated; in addition, the stigmasterol is added, so that the invention has the function of promoting permeation, further promotes the absorption of active ingredients, and can be synergistic with a traditional Chinese medicine preparation, and can resist inflammation and wrinkle and tighten skin. The hot compress bag containing volcanic rock prepared by the invention can promote blood circulation, relieve dysmenorrhea, warm channels, dispel cold, promote blood circulation to remove blood stasis, reduce irregular menstruation, tighten skin, inhibit bacteria and resist inflammation, and prevent and treat gynecological diseases.
The invention is realized by the following technical scheme:
the utility model provides a hot compress package that contains volcanic, includes box and dressing package, dressing package can dismantle and run through and locate the box middle part, box outer wall symmetry is equipped with the band, the box inner wall is equipped with the electric plate for heat the box, dressing package includes the bag body and adorns the active ingredient in the bag body, the bag body is non-woven fabrics material, the active ingredient includes the component of following parts by weight: volcanic rock-Ca (OH) 2 90-200 parts of modified diatomite-CaO 2 60-140 parts of Chinese herbal medicine preparation, 30-50 parts of biological active agent, 12-18 parts of stigmasterol and 8-12 parts of stigmasterol.
Further, the volcanic rock-Ca (OH) 2 The preparation method of (2) comprises the following steps:
(1) Removing impurities from volcanic rock, crushing, putting into a ball mill, ball-milling for 1-1.5 h, sieving with a 100-mesh sieve, washing with deionized water for 3 times, soaking for 12-14 h times in 1 mol/L HCl solution, washing with deionized water to pH of 6.9-7.2, drying at 80 ℃, adding into 0.1 mol/L ferric chloride solution, soaking for 1 h, washing with distilled water for 3 times, drying at 80 ℃, putting into a mixed solution of NaOH and ethanol for 3 h, calcining for 2-3 h at 200-250 ℃ after drying at 110 ℃, washing with distilled water after cooling to room temperature, and drying at room temperature to obtain modified volcanic rock;
(2) Ca (OH) 2 Dissolving the calcium carbonate and sodium sulfate in deionized water according to a mass ratio of 35:1, wherein Ca (OH) 2 The mass volume ratio of the modified acrylic acid and deionized water is 1 g to 50 mL, and the modified acrylic acid and deionized water prepared in the step (1) is addedVolcanic rock, modified volcanic rock and Ca (OH) 2 The mass ratio of (2) is 5:4, after the reaction in ice water bath of 5 h, standing for 1 to 1.5 h, and filtering to obtain filter residue 1;
(3) Uniformly mixing the filter residue 1 obtained in the step (2) with deionized water, wherein the mass volume ratio of the filter residue 1 to the deionized water is 1 g:10 mL, heating to 50-60 ℃, stirring at 180 rpm for 30 min, filtering to obtain filter residue 2, and drying the filter residue 2 at 70 ℃ to obtain volcanic rock-Ca (OH) 2 。
Further, the concentration of NaOH in the mixed solution of NaOH and ethanol in the step (1) is 0.3 mol/L, and the concentration of ethanol is 80-90vol%.
Further, the modified diatomite-CaO 2 The preparation method of (2) comprises the following steps:
I. ball milling diatomite, sieving with a 200-mesh sieve, soaking in a 30wt% NaCl solution for 1 h, heating to 80 ℃ and then continuously soaking for 2 h, wherein the mass-volume ratio of the diatomite to the NaCl solution is 1 g to 4 mL, cooling to 40 ℃, adding gelatin particles, wherein the mass ratio of the gelatin particles to the diatomite is 2:5, continuously stirring, heating to 60 ℃ at the speed of 2 ℃/min, continuously stirring for 30-40 min after reaching 60 ℃, filtering, washing with deionized water for 3 times, placing into a muffle furnace at 400 ℃ for calcining for 3-5 h, adding into a 10 mg/mL gentian acid solution, drying at 120 ℃, the solid-liquid ratio is 1 g to 2 mL, adding into a 4-carboxyl cinnamic acid solution at 0.1 mol/L, drying at 120 ℃, washing with deionized water, and drying at 60 ℃ to obtain modified diatomite;
Dissolving calcium peroxide in polyethylene glycol 400, wherein the mass volume ratio of the calcium peroxide to the polyethylene glycol 400 is 1 g to 15 mL, adding 0.3 mol/L hydrochloric acid solution, the volume ratio of the hydrochloric acid solution to the polyethylene glycol 400 is 2.5 to 1, stirring for 24: 24 h, centrifuging, washing the precipitate with absolute ethyl alcohol for three times, drying at normal temperature, adding absolute ethyl alcohol, the solid-liquid ratio is 4 mg to 5 mL, and carrying out ultrasonic treatment for 1-1.5: 1.5 h to obtain a mixed solution I;
III, immersing the modified diatomite obtained in the step I in the mixed solution I prepared in the step II, wherein the mass volume ratio of the modified diatomite to the mixed solution I is 1 g:20 mL, stirring for 30 min, heating to 80 ℃, preserving heat for 2-3 h, filtering, and vacuum drying at 60 ℃ to obtain the modified diatomite-CaO 2 。
Further, the preparation method of the Chinese herbal medicine preparation comprises the following steps:
(a) Washing cortex Phellodendri, cortex Dictamni Radicis, fructus Cnidii, herba Sargassum, and folium Ilicis Purpureae, drying, mixing at a mass ratio of 1:2:2:1:3, pulverizing, sieving with 40 mesh sieve to obtain coarse powder of Chinese herbal medicine, adding 65vol% ethanol water solution, mixing coarse powder of Chinese herbal medicine with ethanol water solution at a mass ratio of 1:5, ultrasonic treating with 2 h, and filtering to obtain filtrate a and residue a;
(b) Regulating the pH value of the filtrate a obtained in the step (a) to 5-6 by using 0.1 mol/L citric acid-sodium citrate buffer solution, heating to 70-80 ℃, preserving heat for 2-3 h, cooling to room temperature, concentrating to 20% of the original volume at 60 ℃ and 0.1 MPa, and spray drying to obtain a product a;
(c) Drying the filter residue a obtained in the step (a) at 50 ℃, grinding, sieving with a 100-mesh sieve, adding into 0.1 mol/L acetic acid-sodium acetate buffer solution, wherein the mass volume ratio of the filter residue a to the acetic acid-sodium acetate buffer solution is 1 g:20 mL, adding cellulase, the mass ratio of the cellulase to the filter residue a is 1:2, centrifuging after constant-temperature water bath 48 and h at 40 ℃, washing the precipitate with deionized water for 3 times, freeze-drying, adding the precipitate and deionized water into a reaction kettle according to the mass ratio of 1:15, uniformly mixing, regulating the pH to 8-8.5 with sodium hydroxide, continuously stirring and heating to 90 ℃, adding 6-dimethylpyrimidine with the weight of the filter residue a to react for 1-2 h, cooling to room temperature, filtering, washing the precipitate with deionized water for 3 times, and drying at 50 ℃ to obtain a product b;
(d) And (3) uniformly mixing the product a obtained in the step (b) and the product b obtained in the step (c) according to the mass ratio of 2:1 to obtain the Chinese herbal medicine preparation.
Further, the preparation method of the bioactive agent comprises the following steps:
(i) Washing and drying enteromorpha, kelp and ulva, mixing according to the mass ratio of 1:2:1, crushing and sieving with a 80-mesh sieve to obtain seaweed powder, adding the seaweed powder into ultrapure water, uniformly mixing, placing the seaweed powder and the ultrapure water in a high-pressure sterilization pot 3-4 h with the mass volume ratio of 1 g:20 mL and the mass volume ratio of 0.15 MPa at 130 ℃, cooling to room temperature, adding p-hydroxybenzoic acid to the final concentration of 20 mmol/L, and stirring for 30 min to obtain a mixed solution i;
(ii) Adding 95vol% ethanol solution into the mixed solution i obtained in the step (i), wherein the volume-mass ratio of the ethanol solution to seaweed powder is 5 mL:1 g, refluxing for 2-3 h, filtering, adding 1 mol/L dipotassium hydrogen phosphate-potassium dihydrogen phosphate buffer solution into the precipitate, carrying out microwave extraction for 3 times, wherein the volume ratio of the dipotassium hydrogen phosphate-potassium dihydrogen phosphate buffer solution to the ethanol solution is 3:1, carrying out microwave power for 1700W at intervals of 5 min, wherein the extraction temperature is 80 ℃ each time, and filtering to obtain a precipitate to obtain a mixture ii;
(iii) Washing the mixture ii obtained in the step ii with deionized water for three times, uniformly mixing the mixture ii with deionized water, wherein the mass volume ratio of the mixture ii to the deionized water is 1 g to 12 mL, adding hydroquinone, the mass ratio of the hydroquinone to the mixture ii is 1 to 32, stirring at room temperature for 1-1.5 and h, filtering, drying at 55 ℃, grinding and sieving with a 500-mesh sieve to obtain the bioactive agent.
The invention also provides a preparation method of the hot compress pack containing volcanic rock, which comprises the following steps:
s1: volcanic rock-Ca (OH) 2 Modified diatomite-CaO 2 Pulverizing Chinese herbal preparation, bioactive agent and stigmasterol, sieving with 80-100 mesh sieve, and mixing under nitrogen-filled environment to obtain mixture;
S2: uniformly spreading the mixture obtained in the step S1 on two pieces of breathable non-woven fabrics with the same size and the same material, reserving gaps of 1 cm around, covering the other piece of breathable non-woven fabrics relatively above, sealing four sides, and preserving in a dry and sealed environment to obtain a dressing bag;
s3: and (3) placing the dressing bag prepared in the step (S2) in the middle of the box body to obtain the hot compress bag containing volcanic rocks.
Further, the mixture in the step S2 is laid on the breathable non-woven fabric in an amount of 1 g/cm 2 。
Further, the four-sided sealing method in step S2 may be a sewing or adhesive bonding method.
Further, the dressing package is 50-60 cm long and 4-7 cm wide.
Further, the structure of the thermal pack containing volcanic rock is schematically shown in fig. 1.
Compared with the prior art, the invention has the following beneficial effects:
the hot compress bag comprises the box body and the dressing bag, the dressing bag is detachable and adhered to underpants for use, the effect of inhibiting bacteria and diminishing inflammation of external vagina can be better met, the hot compress bag can also be connected with the box body, is bound to the waist and is used close to the lower abdomen, the purposes of warming uterus and dispelling cold and promoting blood circulation can be better met, meanwhile, normal use of menstrual women is not hindered, the box body is convenient to carry, the dressing bag can be better contacted with a human body by the box body, and the electric heating plate arranged in the box body can heat the box body. The invention prepares volcanic rock-Ca (OH) 2 Volcanic rock has natural pores and good adsorptivity, and the microporous structures can realize physical adsorption of carbon dioxide, and the carbon dioxide adsorbed by the volcanic rock can be transferred to Ca (OH) 2 Generates exothermic reaction, emits heat, and volcanic rock-Ca (OH) 2 Can reduce heat loss and ensure CO 2 To Ca (OH) 2 The volcanic rock has better heat release effect, can emit heat by far infrared, has large specific surface area, can store a large amount of gas and heat, stores carbon dioxide and slowly transmits the carbon dioxide to Ca (OH) 2 Improving heat release time, and volcanic rock is rich in minerals and microelements, and has effects of promoting metabolism of cells and enhancing immunity, and volcanic rock-Ca (OH) 2 Has good heat accumulation and temperature rising functions, and is superior to volcanic rock and Ca (OH) 2 The simple superposition effect enables the hot compress bag prepared by the invention to continuously and spontaneously heat, plays a better role in hot compress by matching with the heating function of the box body, promotes blood circulation, relieves dysmenorrhea, warms channels, dissipates cold, activates blood circulation to remove blood stasis, reduces irregular menstruation and prevents and treats gynecological diseases. The invention prepares the modified diatomite-CaO 2 The diatomite is modified to absorb water and transfer the water to CaO 2 The oxygen is slowly released, the water loss is small, the utilization rate is high, the oxygen release amount is large, the female pudendum can be kept clean and dry by absorbing the water, the bacterial growth is reduced, the infection is prevented, and the bacterial growth induced by pudendum hypoxia can be relieved and prevented by releasing the oxygen, so that the local pruritus and inflammatory infection can be relieved and prevented. The invention prepares a Chinese herbal medicine preparation containing a plurality of active ingredients and used for harmonizing The traditional Chinese medicine composition has the advantages of synergistic effect, easy absorption by human body, small irritation, mild and non-sensitization, suitability for female pudendum, promotion of blood circulation, alleviation of female dysmenorrhea, bacteriostasis, anti-inflammation, tightening of skin, treatment and prevention of gynecological diseases such as colpitis, and meanwhile, the hot compress can further promote absorption and promote drug effect. The bioactive agent prepared by the invention can maintain microecological balance of female genital tract, regulate acid-base balance of genital tract, maintain acid environment of genital tract, inhibit growth of harmful microorganism, promote reproduction of beneficial bacteria, maintain and restore normal bacteria balance, thereby preventing and treating vaginal infection and inflammation. The stigmasterol is added, so that the invention has the function of promoting permeation, further promotes the absorption of active ingredients, and can be synergistic with a traditional Chinese medicine preparation, resist inflammation and wrinkle and tighten skin.
Drawings
In order to more clearly illustrate the invention or the technical solutions of the prior art, the drawings which are used in the description of the embodiments or the prior art will be briefly described, it being obvious that the drawings in the description below are only of the invention and that other drawings can be obtained from them without inventive effort for a person skilled in the art.
FIG. 1 is a schematic view showing the structure of a thermal pack containing volcanic rock according to the present invention;
FIG. 2 is a volcanic rock-Ca (OH) according to example 1 of the present invention 2 Is a scanning image of the electron microscope;
FIG. 3 is a modified diatomite-CaO according to example 1 of the present invention 2 Is a scanning image of the electron microscope;
FIG. 4 is a graph showing the oxygen release effect of the dressing packages according to example 2 and comparative examples 1-4 of the present invention;
fig. 5 is a graph of the overall effectiveness of the dressing package of example 2 and comparative examples 1-4 of the present invention for treatment of pudendum laxis.
Wherein, in fig. 1, 1: banding, 2: dressing package, 3: box, 4: an electric heating plate.
Detailed Description
The present invention will be further described in detail with reference to the following specific examples, but the present invention is not limited to the following examples, for the purpose of making the objects, technical solutions and advantages of the present invention more apparent.
Unless otherwise specified, the chemical reagents involved in the present invention are all commercially available.
Example 1: the embodiment provides a hot compress bag containing volcanic rock, which comprises a box body 3 and a dressing bag 2, wherein the dressing bag 2 is detachably and penetratingly arranged in the middle of the box body 3, the outer wall of the box body is symmetrically provided with a binding belt 1, an electric heating plate 4 is arranged in the box body, and the electric heating plate 4 is used for heating the box body 3 to improve the hot compress effect; the dressing bag 2 comprises a bag body and active ingredients arranged in the bag body, wherein the bag body is made of non-woven fabrics, and the active ingredients comprise the following components in parts by weight: volcanic rock-Ca (OH) 2 200 parts of modified diatomite-CaO 2 140 parts of Chinese herbal medicine preparation 50 parts, 18 parts of bioactive agent and 12 parts of stigmasterol.
The volcanic rock-Ca (OH) 2 The preparation method of (2) comprises the following steps:
(1) Removing impurities from volcanic rock, crushing, putting into a ball mill, ball-milling for 1.5 and h, sieving with a 100-mesh sieve, washing with deionized water for 3 times, soaking in 1 mol/L HCl solution for 14 h, washing with deionized water to pH 7.2, drying at 80 ℃, adding 0.1 mol/L ferric chloride solution for 1 h, washing with distilled water for 3 times, drying at 80 ℃, soaking in a mixed solution of NaOH and ethanol for 3 hours, wherein the concentration of NaOH in the mixed solution of NaOH and ethanol is 0.3 mol/L, the concentration of ethanol is 90vol%, the solid-liquid ratio is 1 g/3 mL, drying at 110 ℃, putting into a muffle furnace, calcining at 250 ℃ for 3 h, cooling to room temperature, washing with distilled water, and drying at room temperature to obtain modified volcanic rock;
(2) Ca (OH) 2 Dissolving the calcium carbonate and sodium sulfate in deionized water according to a mass ratio of 35:1, wherein Ca (OH) 2 The mass volume ratio of the modified volcanic rock to deionized water is 1 g to 50 mL, and the modified volcanic rock and Ca (OH) prepared in the step (1) are added 2 The mass ratio of (2) is 5:4, after the reaction in ice water bath is carried out for 5 h, the mixture is kept stand for 1.5 h, and filter residue 1 is obtained after filtration;
(3) Mixing the filter residue 1 obtained in the step (2) with deionized waterMixing uniformly, heating the filter residue 1 and deionized water to 60 ℃ and stirring at 180 rpm for 30 min at a mass volume ratio of 1 g to 10 mL, filtering to obtain filter residue 2, and drying the filter residue 2 at 70 ℃ to obtain volcanic rock-Ca (OH) 2 The scanning diagram of the electron microscope is shown in figure 2, and volcanic rock-Ca (OH) 2 Spherical, with good dispersibility and rough surface, indicating Ca (OH) 2 Successful loading of volcanic rock-Ca (OH) 2 Successful preparation.
The modified diatomite-CaO 2 The preparation method of (2) comprises the following steps:
I. ball milling diatomite, sieving with a 200-mesh sieve, soaking in a 30wt% NaCl solution for 1 h, heating to 80 ℃ and then continuously soaking for 2 h, wherein the mass-volume ratio of the diatomite to the NaCl solution is 1 g to 4 mL, cooling to 40 ℃, adding gelatin particles, wherein the mass ratio of the gelatin particles to the diatomite is 2 to 5, continuously stirring, heating to 60 ℃ at the speed of 2 ℃/min, continuously stirring for 40 min after reaching 60 ℃, filtering, washing with deionized water for 3 times, placing into a muffle furnace at 400 ℃ for calcination for 5 h, adding into a gentian acid solution at 10 mg/mL, drying at 120 ℃, wherein the solid-liquid ratio is 1 g to 2 mL, adding into a 4-carboxyl cinnamic acid solution at 0.1 mol/L, drying at 120 ℃, drying at 60 ℃ after washing with deionized water, and obtaining modified diatomite;
Dissolving calcium peroxide in polyethylene glycol 400, wherein the mass volume ratio of the calcium peroxide to the polyethylene glycol 400 is 1 g to 15 mL, adding 0.3 mol/L hydrochloric acid solution, the volume ratio of the hydrochloric acid solution to the polyethylene glycol 400 is 2.5 to 1, stirring for 24 to h, centrifuging, washing the precipitate with absolute ethyl alcohol for three times, drying at normal temperature, adding absolute ethyl alcohol, the solid-liquid ratio is 4 mg to 5 mL, and carrying out ultrasonic treatment for 1.5 to h to obtain a mixed solution I;
III, immersing the modified diatomite obtained in the step I into the mixed solution I prepared in the step II, wherein the mass volume ratio of the modified diatomite to the mixed solution I is 1 g:20 mL, stirring for 30 min, heating to 80 ℃, preserving heat for 3 h, filtering, and vacuum drying at 60 ℃ to obtain the modified diatomite-CaO 2 The scanning image of the electron microscope is shown in figure 3, the outermost layer of the diatomite is attached with flaky substances and is more dispersed, and agglomeration does not occur to indicate CaO 2 Diatomite is successfully loaded, and modified diatomite-CaO is used 2 Successful preparation.
The preparation method of the Chinese herbal medicine preparation comprises the following steps:
(a) Washing cortex Phellodendri, cortex Dictamni Radicis, fructus Cnidii, herba Sargassum, and folium Ilicis Purpureae, drying, mixing at a mass ratio of 1:2:2:1:3, pulverizing, sieving with 40 mesh sieve to obtain coarse powder of Chinese herbal medicine, adding 65vol% ethanol water solution, mixing coarse powder of Chinese herbal medicine with ethanol water solution at a mass ratio of 1:5, ultrasonic treating with 2 h, and filtering to obtain filtrate a and residue a;
(b) Regulating the pH value of the filtrate a obtained in the step (a) to 6 by using 0.1 mol/L citric acid-sodium citrate buffer solution, heating to 80 ℃, preserving heat for 3 h, cooling to room temperature, concentrating to 20% of the original volume at 60 ℃ and 0.1 MPa, and spray-drying to obtain a product a;
(c) Drying the filter residue a obtained in the step (a) at 50 ℃, grinding, sieving with a 100-mesh sieve, adding into 0.1 mol/L acetic acid-sodium acetate buffer solution, wherein the mass volume ratio of the filter residue a to the acetic acid-sodium acetate buffer solution is 1 g:20 mL, adding cellulase, the mass ratio of the cellulase to the filter residue a is 1:2, centrifuging after constant-temperature water bath 48 and h at 40 ℃, washing the precipitate with deionized water for 3 times, freeze-drying, adding the precipitate and deionized water into a reaction kettle according to the mass ratio of 1:15, uniformly mixing, adjusting the pH to 8.5 with sodium hydroxide, continuously stirring and heating to 90 ℃, adding 6-dimethylpyrimidine with the weight of the filter residue a to react for 2: 2 h, cooling to room temperature, filtering, washing the precipitate with deionized water for 3 times, and drying at 50 ℃ to obtain a product b;
(d) And (3) uniformly mixing the product a obtained in the step (b) and the product b obtained in the step (c) according to the mass ratio of 2:1 to obtain the Chinese herbal medicine preparation.
The preparation method of the bioactive agent comprises the following steps:
(i) Washing and drying enteromorpha, kelp and ulva, mixing according to the mass ratio of 1:2:1, crushing and sieving with a 80-mesh sieve to obtain seaweed powder, adding the seaweed powder into ultrapure water, uniformly mixing, placing the seaweed powder and the ultrapure water in a high-pressure sterilization pot 4 h with the mass volume ratio of 1 g to 20 mL and the temperature of 130 ℃ and 0.15 MPa, cooling to room temperature, adding p-hydroxybenzoic acid to the final concentration of 20 mmol/L, and stirring for 30 min to obtain a mixed solution i;
(ii) Adding 95vol% ethanol solution into the mixed solution i obtained in the step (i), wherein the volume-mass ratio of the ethanol solution to seaweed powder is 5 mL:1 g, refluxing 3 h, filtering, adding 1 mol/L dipotassium hydrogen phosphate-potassium dihydrogen phosphate buffer solution into the precipitate, carrying out microwave extraction for 3 times, wherein the volume ratio of the dipotassium hydrogen phosphate-potassium dihydrogen phosphate buffer solution to the ethanol solution is 3:1, carrying out microwave power for 1700W at intervals of 5 min, wherein the extraction temperature is 80 ℃ each time, and filtering to obtain a precipitate to obtain a mixture ii;
(iii) Washing the mixture ii obtained in the step ii with deionized water for three times, uniformly mixing the mixture ii with deionized water, wherein the mass volume ratio of the mixture ii to the deionized water is 1 g/12 mL, adding hydroquinone, the mass ratio of the hydroquinone to the mixture ii is 1:32, stirring at room temperature for 1.5/h, filtering, drying at 55 ℃, grinding, and sieving with a 500-mesh sieve to obtain the bioactive agent.
The embodiment also provides a preparation method of the hot compress pack containing volcanic rock, which comprises the following steps:
s1: volcanic rock-Ca (OH) 2 Modified diatomite-CaO 2 Pulverizing Chinese herbal medicine preparation, bioactive agent and stigmasterol, sieving with 100 mesh sieve, and mixing under nitrogen-filled environment to obtain mixture;
s2: uniformly spreading the mixture obtained in the step S1 on one of the two breathable non-woven fabrics with the same size and material, wherein the spreading amount is 1 g/cm 2 The periphery of the dressing bag is provided with a gap of 1 cm, the other breathable non-woven fabric is covered above the dressing bag relatively, four sides of the dressing bag are sealed by adopting a sewing method, and the dressing bag is preserved in a dry and sealed environment to prepare the dressing bag with the length of 60 cm and the width of 7 cm;
s3: and (3) placing the dressing bag prepared in the step (S2) in the middle of the box body to obtain the hot compress bag containing volcanic rocks.
Example 2: the embodiment provides a hot compress bag containing volcanic rock, which comprises a box body 3 and a dressing bag 2, wherein the dressing bag 2 is detachable and penetrates through the middle part of the box body 3, and the outer wall of the box body is symmetrically provided with binding bands 1; the dressing bag 2 comprises a bag body and active ingredients arranged in the bag body, wherein the bag body is made of non-woven fabrics, and the active ingredients comprise the following components in parts by weight: volcanic rock-Ca (OH) 2 90 parts of modified diatomite-CaO 2 60 parts of Chinese herbal medicine preparation 30 parts,12 parts of bioactive agent and 8 parts of stigmasterol.
The volcanic rock-Ca (OH) 2 The preparation method of (2) comprises the following steps:
(1) Removing impurities from volcanic rock, crushing, putting into a ball mill, ball-milling for 1 h, sieving with a 100-mesh sieve, washing with deionized water for 3 times, soaking in 1 mol/L HCl solution for 12 h, washing with deionized water to pH 7.2, drying at 80 ℃, adding 0.1 mol/L ferric chloride solution for 1 h, washing with distilled water for 3 times, drying at 80 ℃, soaking in a mixed solution of NaOH and ethanol for 3 hours, wherein the concentration of NaOH in the mixed solution of NaOH and ethanol is 0.3 mol/L, the concentration of ethanol is 80vol%, the solid-liquid ratio is 1 g to 3 mL, drying at 110 ℃, putting into a muffle furnace, calcining at 200 ℃ for 2 h, cooling to room temperature, washing with distilled water, and drying at room temperature to obtain modified volcanic rock;
(2) Ca (OH) 2 Dissolving the calcium carbonate and sodium sulfate in deionized water according to a mass ratio of 35:1, wherein Ca (OH) 2 The mass volume ratio of the modified volcanic rock to deionized water is 1 g to 50 mL, and the modified volcanic rock and Ca (OH) prepared in the step (1) are added 2 The mass ratio of (2) is 5:4, after the reaction in ice water bath is carried out for 5 h, the mixture is kept stand for 1 h, and filter residue 1 is obtained after filtration;
(3) Uniformly mixing the filter residue 1 obtained in the step (2) with deionized water, wherein the mass volume ratio of the filter residue 1 to the deionized water is 1 g:10 mL, heating to 50 ℃, stirring at 180 rpm for 30 min, filtering to obtain filter residue 2, and drying the filter residue 2 at 70 ℃ to obtain volcanic rock-Ca (OH) 2 。
The modified diatomite-CaO 2 The preparation method of (2) comprises the following steps:
I. ball milling diatomite, sieving with a 200-mesh sieve, soaking in a 30wt% NaCl solution for 1 h, heating to 80 ℃ and then continuously soaking for 2 h, wherein the mass-volume ratio of the diatomite to the NaCl solution is 1 g to 4 mL, cooling to 40 ℃, adding gelatin particles, wherein the mass ratio of the gelatin particles to the diatomite is 2 to 5, continuously stirring, heating to 60 ℃ at the speed of 2 ℃/min, continuously stirring for 30 min after reaching 60 ℃, filtering, washing with deionized water for 3 times, placing into a muffle furnace at 400 ℃ for calcination for 3 h, adding into a 10 mg/mL gentian acid solution, drying at 120 ℃, wherein the solid-liquid ratio is 1 g to 2 mL, adding into a 0.1 mol/L4-carboxyl cinnamic acid solution, drying at 120 ℃, drying at 60 ℃ after washing with deionized water, and obtaining modified diatomite;
Dissolving calcium peroxide in polyethylene glycol 400, wherein the mass volume ratio of the calcium peroxide to the polyethylene glycol 400 is 1 g to 15 mL, adding 0.3 mol/L hydrochloric acid solution, the volume ratio of the hydrochloric acid solution to the polyethylene glycol 400 is 2.5:1, stirring for 24: 24 h, centrifuging, washing the precipitate with absolute ethyl alcohol for three times, drying at normal temperature, adding absolute ethyl alcohol, the solid-liquid ratio is 4 mg to 5 mL, and carrying out ultrasonic treatment for 1: 1 h to obtain a mixed solution I;
III, immersing the modified diatomite obtained in the step I into the mixed solution I prepared in the step II, wherein the mass volume ratio of the modified diatomite to the mixed solution I is 1 g:20 mL, stirring for 30 min, heating to 80 ℃, preserving heat for 2 h, filtering, and vacuum drying at 60 ℃ to obtain the modified diatomite-CaO 2 。
The preparation method of the Chinese herbal medicine preparation comprises the following steps:
(a) Washing cortex Phellodendri, cortex Dictamni Radicis, fructus Cnidii, herba Sargassum, and folium Ilicis Purpureae, drying, mixing at a mass ratio of 1:2:2:1:3, pulverizing, sieving with 40 mesh sieve to obtain coarse powder of Chinese herbal medicine, adding 65vol% ethanol water solution, mixing coarse powder of Chinese herbal medicine with ethanol water solution at a mass ratio of 1:5, ultrasonic treating with 2 h, and filtering to obtain filtrate a and residue a;
(b) Regulating the pH value of the filtrate a obtained in the step (a) to 5 by using 0.1 mol/L citric acid-sodium citrate buffer solution, heating to 70 ℃, preserving heat for 2 h, cooling to room temperature, concentrating to 20% of the original volume at 60 ℃ and 0.1 MPa, and spray-drying to obtain a product a;
(c) Drying the filter residue a obtained in the step (a) at 50 ℃, grinding, sieving with a 100-mesh sieve, adding into 0.1 mol/L acetic acid-sodium acetate buffer solution, wherein the mass volume ratio of the filter residue a to the acetic acid-sodium acetate buffer solution is 1 g:20 mL, adding cellulase, the mass ratio of the cellulase to the filter residue a is 1:2, centrifuging after constant-temperature water bath 48 and h at 40 ℃, washing the precipitate with deionized water for 3 times, freeze-drying, adding the precipitate and deionized water into a reaction kettle according to the mass ratio of 1:15, uniformly mixing, adjusting the pH to 8 with sodium hydroxide, continuously stirring and heating to 90 ℃, adding 6-dimethylpyrimidine with the weight of 1/10 of the filter residue a, reacting 1:1 h, cooling to room temperature, filtering, washing the precipitate with deionized water for 3 times, and drying at 50 ℃ to obtain a product b;
(d) And (3) uniformly mixing the product a obtained in the step (b) and the product b obtained in the step (c) according to the mass ratio of 2:1 to obtain the Chinese herbal medicine preparation.
The preparation method of the bioactive agent comprises the following steps:
(i) Washing and drying enteromorpha, kelp and ulva, mixing according to the mass ratio of 1:2:1, crushing and sieving with a 80-mesh sieve to obtain seaweed powder, adding the seaweed powder into ultrapure water, uniformly mixing, placing the seaweed powder and the ultrapure water in a high-pressure sterilization pot 3 h with the mass volume ratio of 1 g to 20 mL and the temperature of 130 ℃ and 0.15 MPa, cooling to room temperature, adding p-hydroxybenzoic acid to the final concentration of 20 mmol/L, and stirring for 30 min to obtain a mixed solution i;
(ii) Adding 95vol% ethanol solution into the mixed solution i obtained in the step (i), wherein the volume-mass ratio of the ethanol solution to seaweed powder is 5 mL:1 g, refluxing 2 h, filtering, adding 1 mol/L dipotassium hydrogen phosphate-potassium dihydrogen phosphate buffer solution into the precipitate, carrying out microwave extraction for 3 times, wherein the volume ratio of the dipotassium hydrogen phosphate-potassium dihydrogen phosphate buffer solution to the ethanol solution is 3:1, carrying out microwave power for 1700W at intervals of 5 min, wherein the extraction temperature is 80 ℃ each time, and filtering to obtain a precipitate to obtain a mixture ii;
(iii) Washing the mixture ii obtained in the step ii with deionized water for three times, uniformly mixing the mixture ii with deionized water, wherein the mass volume ratio of the mixture ii to the deionized water is 1 g/12 mL, adding hydroquinone, the mass ratio of the hydroquinone to the mixture ii is 1:32, stirring the mixture at room temperature for 1 h, filtering, drying the mixture at 55 ℃, grinding the mixture, and sieving the mixture with a 500-mesh sieve to obtain the bioactive agent.
The embodiment also provides a preparation method of the hot compress pack containing volcanic rock, which comprises the following steps:
s1: volcanic rock-Ca (OH) 2 Modified diatomite-CaO 2 Pulverizing Chinese herbal medicine preparation, bioactive agent and stigmasterol, sieving with 80 mesh sieve, and mixing under nitrogen-filled environment to obtain mixture;
s2: taking two breathable non-woven fabrics with the same size and the same material, uniformly spreading the mixture obtained in the step S1 on one of the two breathable non-woven fabrics The tiling amount of the block breathable non-woven fabric is 1 g/cm 2 The periphery is provided with a gap of 1 cm, the other breathable non-woven fabric is covered above the dressing bag relatively, four sides are sealed by adopting an adhesive, and the dressing bag is preserved in a dry and sealed environment to prepare a dressing bag with the length of 50 cm and the width of 4 cm;
s3: and (3) placing the dressing bag prepared in the step (S2) in the middle of the box body to obtain the hot compress bag containing volcanic rocks.
Example 3: the embodiment provides a hot compress bag containing volcanic rock, which comprises a box body 3 and a dressing bag 2, wherein the dressing bag 2 is detachable and penetrates through the middle part of the box body 3, and the outer wall of the box body is symmetrically provided with binding bands 1; the dressing bag 2 comprises a bag body and active ingredients arranged in the bag body, wherein the bag body is made of non-woven fabrics, and the active ingredients comprise the following components in parts by weight: volcanic rock-Ca (OH) 2 150 parts of modified diatomite-CaO 2 100 parts of Chinese herbal medicine preparation 40 parts, 15 parts of bioactive agent and 10 parts of stigmasterol.
The volcanic rock-Ca (OH) 2 The preparation method of (2) comprises the following steps:
(1) Removing impurities from volcanic rock, crushing, putting into a ball mill, ball-milling for 1.2 and h, sieving with a 100-mesh sieve, washing with deionized water for 3 times, soaking in 1 mol/L HCl solution for 13 h, washing with deionized water to pH 7 and drying at 80 ℃, adding 0.1 mol/L ferric chloride solution for 1 h, washing with distilled water for 3 times and drying at 80 ℃, putting into a mixed solution of NaOH and ethanol for 3 hours, wherein the concentration of NaOH in the mixed solution of NaOH and ethanol is 0.3 mol/L, the concentration of ethanol is 85vol%, the solid-liquid ratio is 1 g to 3 mL, drying at 110 ℃, putting into a muffle furnace, calcining at 250 ℃ for 2.5 h, cooling to room temperature, washing with distilled water, and drying at room temperature to obtain modified volcanic rock;
(2) Ca (OH) 2 Dissolving the calcium carbonate and sodium sulfate in deionized water according to a mass ratio of 35:1, wherein Ca (OH) 2 The mass volume ratio of the modified volcanic rock to deionized water is 1 g to 50 mL, and the modified volcanic rock and Ca (OH) prepared in the step (1) are added 2 The mass ratio of (2) is 5:4, after the reaction in ice water bath is carried out for 5 h, the mixture is kept stand for 1.2 h, and filter residue 1 is obtained after filtration;
(3) Uniformly mixing the filter residue 1 obtained in the step (2) with deionized water, wherein the mass volume ratio of the filter residue 1 to the deionized water is 1 g:10 mL, heating to 55 ℃, stirring at 180 rpm for 30 min, filtering to obtain filter residue 2, and drying the filter residue 2 at 70 ℃ to obtain volcanic rock-Ca (OH) 2 。
The modified diatomite-CaO 2 The preparation method of (2) comprises the following steps:
I. ball milling diatomite, sieving with a 200-mesh sieve, soaking in a 30wt% NaCl solution for 1 h, heating to 80 ℃ and then continuously soaking for 2 h, wherein the mass-volume ratio of the diatomite to the NaCl solution is 1 g to 4 mL, cooling to 40 ℃, adding gelatin particles, wherein the mass ratio of the gelatin particles to the diatomite is 2 to 5, continuously stirring, heating to 60 ℃ at the speed of 2 ℃/min, continuously stirring for 35 min after reaching 60 ℃, filtering, washing with deionized water for 3 times, placing into a muffle furnace at 400 ℃ for calcination for 4 h, adding into a gentian acid solution at 10 mg/mL, drying at 120 ℃, wherein the solid-liquid ratio is 1 g to 2 mL, adding into a 4-carboxyl cinnamic acid solution at 0.1 mol/L, drying at 120 ℃, drying at 60 ℃ after washing with deionized water, and obtaining modified diatomite;
Dissolving calcium peroxide in polyethylene glycol 400, wherein the mass volume ratio of the calcium peroxide to the polyethylene glycol 400 is 1 g to 15 mL, adding 0.3 mol/L hydrochloric acid solution, the volume ratio of the hydrochloric acid solution to the polyethylene glycol 400 is 2.5 to 1, stirring for 24 to h, centrifuging, washing the precipitate with absolute ethyl alcohol for three times, drying at normal temperature, adding absolute ethyl alcohol, the solid-liquid ratio is 4 mg to 5 mL, and carrying out ultrasonic treatment for 1.2 to h to obtain a mixed solution I;
III, immersing the modified diatomite obtained in the step I in the mixed solution I prepared in the step II, wherein the mass volume ratio of the modified diatomite to the mixed solution I is 1 g:20 mL, stirring for 30 min, heating to 80 ℃, preserving heat for 2.5 h, filtering, and vacuum drying at 60 ℃ to obtain the modified diatomite-CaO 2 。
The preparation method of the Chinese herbal medicine preparation comprises the following steps:
(a) Washing cortex Phellodendri, cortex Dictamni Radicis, fructus Cnidii, herba Sargassum, and folium Ilicis Purpureae, drying, mixing at a mass ratio of 1:2:2:1:3, pulverizing, sieving with 40 mesh sieve to obtain coarse powder of Chinese herbal medicine, adding 65vol% ethanol water solution, mixing coarse powder of Chinese herbal medicine with ethanol water solution at a mass ratio of 1:5, ultrasonic treating with 2 h, and filtering to obtain filtrate a and residue a;
(b) Regulating the pH value of the filtrate a obtained in the step (a) to 5.5 by using 0.1 mol/L citric acid-sodium citrate buffer solution, heating to 75 ℃, preserving heat for 2.5 and h, cooling to room temperature, concentrating to 20% of the original volume at 60 ℃ and 0.1 MPa, and spray-drying to obtain a product a;
(c) Drying the filter residue a obtained in the step (a) at 50 ℃, grinding, sieving with a 100-mesh sieve, adding into 0.1 mol/L acetic acid-sodium acetate buffer solution, wherein the mass volume ratio of the filter residue a to the acetic acid-sodium acetate buffer solution is 1 g:20 mL, adding cellulase, the mass ratio of the cellulase to the filter residue a is 1:2, centrifuging after constant-temperature water bath 48 and h at 40 ℃, washing the precipitate with deionized water for 3 times, freeze-drying, adding the precipitate and deionized water into a reaction kettle according to the mass ratio of 1:15, uniformly mixing, adjusting the pH to 8.2 with sodium hydroxide, continuously stirring and heating to 90 ℃, adding 6-dimethylpyrimidine with the weight of the filter residue a to react for 1.5 h, cooling to room temperature, filtering, washing the precipitate with deionized water for 3 times, and drying at 50 ℃ to obtain a product b;
(d) And (3) uniformly mixing the product a obtained in the step (b) and the product b obtained in the step (c) according to the mass ratio of 2:1 to obtain the Chinese herbal medicine preparation.
The preparation method of the bioactive agent comprises the following steps:
(i) Washing and drying enteromorpha, kelp and ulva, mixing according to the mass ratio of 1:2:1, crushing and sieving with a 80-mesh sieve to obtain seaweed powder, adding the seaweed powder into ultrapure water, uniformly mixing, placing the seaweed powder and the ultrapure water in a high-pressure sterilization pot 3.5 h with the mass volume ratio of 1 g:20 mL and the mass volume ratio of 0.15 MPa at 130 ℃, cooling to room temperature, adding p-hydroxybenzoic acid to the final concentration of 20 mmol/L, and stirring for 30 min to obtain a mixed solution i;
(ii) Adding 95vol% ethanol solution into the mixed solution i obtained in the step (i), wherein the volume-mass ratio of the ethanol solution to seaweed powder is 5 mL:1 g, refluxing for 2.5 h, filtering, adding 1 mol/L dipotassium hydrogen phosphate-potassium dihydrogen phosphate buffer solution into the precipitate, carrying out microwave extraction for 3 times, wherein the volume ratio of the dipotassium hydrogen phosphate-potassium dihydrogen phosphate buffer solution to the ethanol solution is 3:1, carrying out microwave power for 1700W at intervals of 5 min, wherein the extraction temperature is 80 ℃ each time, and filtering to obtain a precipitate to obtain a mixture ii;
(iii) Washing the mixture ii obtained in the step ii with deionized water for three times, uniformly mixing the mixture ii with deionized water, wherein the mass volume ratio of the mixture ii to the deionized water is 1 g/12 mL, adding hydroquinone, the mass ratio of the hydroquinone to the mixture ii is 1:32, stirring at room temperature for 1.2 h, filtering, drying at 55 ℃, grinding, and sieving with a 500-mesh sieve to obtain the bioactive agent.
The embodiment also provides a preparation method of the hot compress pack containing volcanic rock, which comprises the following steps:
s1: volcanic rock-Ca (OH) 2 Modified diatomite-CaO 2 Pulverizing Chinese herbal medicine preparation, bioactive agent and stigmasterol, sieving with 90 mesh sieve, and mixing under nitrogen-filled environment to obtain mixture;
s2: uniformly spreading the mixture obtained in the step S1 on one of the two breathable non-woven fabrics with the same size and material, wherein the spreading amount is 1 g/cm 2 The periphery is provided with a gap of 1 cm, the other breathable non-woven fabric is covered above the bag, four sides are sealed by adopting a sewing method, and the bag is preserved in a dry and sealed environment to prepare a dressing bag with the length of 55 cm and the width of 5 cm;
s3: and (3) placing the dressing bag prepared in the step (S2) in the middle of the box body to obtain the hot compress bag containing volcanic rocks.
Comparative example 1 differs from example 1 only in volcanic rock and Ca (OH) which were sieved through a 100 mesh sieve after ball milling with a mass ratio of 1:1 2 Replacement of volcanic rock-Ca (OH) 2 。
Comparative example 2 differs from example 1 only in that the diatomaceous earth and CaO were sieved through a 200 mesh sieve after ball milling with a mass ratio of 1:1 2 Substitution modified diatomite-CaO 2 。
Comparative example 3 differs from example 1 only in that the preparation method of the herbal preparation comprises the following steps: washing cortex Phellodendri, cortex Dictamni Radicis, fructus Cnidii, herba Sargassum, and folium Ilicis Purpureae, drying, mixing at a mass ratio of 1:2:2:1:3, pulverizing, sieving with 40 mesh sieve to obtain coarse powder of Chinese herbal medicine, adding 65vol% ethanol water solution, mixing coarse powder of Chinese herbal medicine with ethanol water solution at a mass ratio of 1:5, ultrasonic treating with 2 h, and filtering to obtain filtrate a and residue a; concentrating filtrate a to 20% of the original volume at 60deg.C and 0.1 MPa, and spray drying to obtain product a; drying the filter residue a at 50 ℃, grinding and sieving with a 100-mesh sieve to obtain a product b; and uniformly mixing the product a and the product b according to the mass ratio of 2:1 to obtain the Chinese herbal medicine preparation.
Comparative example 4 differs from example 1 only in the preparation method of the bioactive agent, comprising the steps of: cleaning and drying Enteromorpha prolifera, kelp and Ulva, mixing according to a mass ratio of 1:2:1, pulverizing, sieving with a 80-mesh sieve to obtain seaweed powder, adding the seaweed powder into ultrapure water, mixing uniformly, placing the seaweed powder and the ultrapure water in an autoclave 4 h with a mass volume ratio of 1 g:20 mL at 130 ℃ and 0.15 MPa, and cooling to room temperature to obtain a mixed solution i; adding 95vol% ethanol solution into the mixed solution i, wherein the volume-mass ratio of the ethanol solution to seaweed powder is 5 mL:1 g, refluxing 3 h, filtering, adding 1 mol/L dipotassium hydrogen phosphate-potassium dihydrogen phosphate buffer solution into the precipitate, carrying out microwave extraction for 3 times, wherein the volume ratio of the dipotassium hydrogen phosphate-potassium dihydrogen phosphate buffer solution to the ethanol solution is 3:1, carrying out microwave power for 1700W, and carrying out 5 min at intervals, wherein the extraction temperature is 80 ℃, and filtering to obtain the precipitate to obtain a mixture ii; the mixture ii was washed three times with deionized water, dried at 55 ℃, and ground through a 500 mesh sieve to obtain the bioactive agent.
Experimental example 1: the dressing packs prepared in example 1 and comparative examples 1 to 4 were wrapped with wet gauze, and after reading room temperature, a thermometer was inserted into the dressing pack, and the time for the temperature to rise to the highest temperature was recorded and the highest temperature was recorded, and the time for the start of cooling and the time for the temperature to be higher than 35 ℃ were recorded. The results are shown in Table 1.
TABLE 1 heating effect of dressing bag
Table 1 results show that the maximum temperature, the onset of cooling time and the time above 35℃of the dressing packages of example 1 and comparative examples 2-4 are significantly higher than that of comparative example 1, and the time to rise to the maximum temperature is significantly lower than that of comparative example 1, indicating volcanic rock and Ca (OH) 2 Is a simple superposition effect of (1)Less than volcanic rock-Ca (OH) prepared by the invention 2 The best effect of example 1 shows that the volcanic-containing hot compress pack has better heating effect, long heating time and high heating temperature.
Experimental example 2: the dressing packs prepared in example 2 and comparative examples 1 to 4 were immersed in PBS solution of pH7.4, and the oxygen content of the solutions was measured with a dissolved oxygen meter at the time of 0 h, 5 h, 10 h, 15 h and 20 h, respectively. The results are shown in FIG. 4.
FIG. 4 shows that the dressing of example 2 and comparative example 1 and comparative examples 3-4 contain significantly higher dissolved oxygen than comparative example 2, indicating that the modified diatomaceous earth-CaO prepared by the present invention 2 The effect is better than that of diatomite and CaO 2 The best effect of example 2 shows that the hot compress pack containing volcanic rock has better oxygen release effect and can effectively reduce microbial infection caused by hypoxia.
Experimental example 3: selecting 100 healthy adult rabbits, dividing into 5 groups of 20 rabbits, and shaving the back of each rabbit by 9 cm 2 . The dressing packs prepared in example 3 and comparative examples 1 to 4 were used in rabbit hair shaving sites, and 24 h, 48 h and 72 h application sites were observed to see whether local irritation reactions such as skin erythema and edema occurred, and the results are shown in table 2.
Table 2 skin irritation test of dressing pack
The results in Table 2 show that the hot compress bag prepared by the invention is safe, has no stimulation and adverse reaction, and can be used by contacting the skin.
Experimental example 4: 500 cases of primary dysmenorrhea patients are selected, the ages are 14-35, the average of the primary dysmenorrhea patients is divided into five groups, diagnosis standards are confirmed by referring to the diagnosis standards in the traditional Chinese medicine science, and organic lesions of reproductive organs are eliminated through B-type ultrasonic examination. The hot compress pack containing volcanic rock prepared in example 3 and comparative examples 1 to 4 was tied to the waist with a belt, the dressing pack was applied to the umbilical region 7 to cm, the pack was changed once a day until the menstrual period was stopped, and the therapeutic effect was counted after 3 months, and the therapeutic effect standard: and (3) healing: the clinical symptoms disappear, the functional activities are normal, and the lower abdominal pain is avoided in the next menstrual period; improvement: the clinical symptoms are partially disappeared or obviously improved; invalidation: no change in clinical symptoms or signs. The results are shown in Table 3.
TABLE 3 therapeutic Effect of Hot pack on dysmenorrhea patients
The results in table 3 show that the treatment efficiency of example 3 and comparative examples 2 and 4 is higher than that of comparative examples 1 and 3, wherein the example 3 has the largest number of recovery cases and high efficiency, indicating that the volcanic-containing heat pack prepared by the invention can effectively treat dysmenorrhea.
Experimental example 5: selecting 450 patients, wherein 150 patients with bacterial vaginitis, 150 patients with candidal vulvovaginitis and 150 patients with trichomonas vaginitis are all aged 21-60 years, and excluding menstrual, gestational and lactation patients; the bacterial vaginitis patients, the candidal vulvovaginitis patients and the trichomonas vaginitis patients are respectively divided into 5 groups of 30 persons, the dressing bags prepared in the example 1 and the comparative examples 1-4 are adhered to underpants for use, the dressing bags are replaced every 12 h, and after 21 d is continuously used, the treatment effect is counted, and the treatment effect evaluation standard is that: and (3) healing: the symptoms disappear, and the gynecological examination and laboratory examination are normal; the effect is shown: the symptoms are obviously reduced, and gynecological examination and laboratory examination are obviously improved; the method is effective: the symptoms are reduced, and gynecological examination and laboratory examination are improved; invalidation: no change after treatment compared with before treatment. The results are shown in Table 4.
Table 4 therapeutic effect of dressing bag on gynecological diseases
Table 4 shows that the total effective rate of the dressing pack prepared in example 1 and comparative examples 1-4 on bacterial vaginitis, candidal vulvovaginitis and trichomonas vaginitis is 90% or more, wherein the best effect of example 1 shows that the hot compress pack containing volcanic rock can effectively inhibit bacteria and diminish inflammation, and treat and prevent gynecological diseases.
Experimental example 6: 150 patients with loose private parts and ages 25-30 are selected, and are equally divided into 5 groups of 30 persons, the dressing bags prepared by using the dressing bags prepared by the method of the embodiment 2 and the dressing bags prepared by using the dressing bags of the comparative examples 1-4 are respectively adhered to underpants before sleeping every night, the dressing bags are taken down after 10 h and are continuously used for 15 d, the gloss and elasticity of the inner walls of the private parts are effective, the total effective rate is counted, and the total effective rate (%) = (the number of effective cases/total patients) is 100%, and the result is shown in fig. 5.
The results of fig. 5 show that the patient's private parts laxity symptoms are largely improved after using the dressing pack of example 2 and comparative examples 1-4, with the best effect of example 2, showing that a volcanic-containing heat pack of the present invention is effective in tightening female pudendum skin.
Those of ordinary skill in the art will appreciate that: the discussion of any of the embodiments above is merely exemplary and is not intended to suggest that the scope of the invention (including the claims) is limited to these examples; the technical features of the above embodiments or in the different embodiments may also be combined within the idea of the invention, the steps may be implemented in any order and there are many other variations of the different aspects of the invention as described above, which are not provided in detail for the sake of brevity.
The present invention is intended to embrace all such alternatives, modifications and variances which fall within the broad scope of the appended claims. Therefore, any omission, modification, equivalent replacement, improvement, etc. of the present invention should be included in the scope of the present invention.
Claims (9)
1. The utility model provides a hot compress package that contains volcanic rock, its characterized in that includes box and dressing package, dressing package can dismantle and run through and locate the box middle part, box outer wall symmetry is equipped with the band, the box inner wall is equipped with the electric plate, dressing package includes the bag body and adorns at the bagThe bag body is made of non-woven fabrics, and comprises the following components in parts by weight: volcanic rock-Ca (OH) 2 90-200 parts of modified diatomite-CaO 2 60-140 parts of Chinese herbal medicine preparation, 30-50 parts of biological active agent, 12-18 parts of stigmasterol and 8-12 parts of stigmasterol.
2. The thermal pack of claim 1, wherein the volcanic rock-Ca (OH) 2 The preparation method of (2) comprises the following steps:
(1) Removing impurities from volcanic rock, crushing, putting into a ball mill, ball-milling for 1-1.5 h, sieving with a 100-mesh sieve, washing with deionized water for 3 times, soaking for 12-14 h times in 1 mol/L HCl solution, washing with deionized water to pH of 6.9-7.2, drying at 80 ℃, adding into 0.1 mol/L ferric chloride solution, soaking for 1 h, washing with distilled water for 3 times, drying at 80 ℃, putting into a mixed solution of NaOH and ethanol for 3 h, calcining for 2-3 h at 200-250 ℃ after drying at 110 ℃, washing with distilled water after cooling to room temperature, and drying at room temperature to obtain modified volcanic rock;
(2) Ca (OH) 2 Dissolving the calcium carbonate and sodium sulfate in deionized water according to a mass ratio of 35:1, wherein Ca (OH) 2 The mass volume ratio of the modified volcanic rock to deionized water is 1 g to 50 mL, and the modified volcanic rock and Ca (OH) prepared in the step (1) are added 2 The mass ratio of (2) is 5:4, after the reaction in ice water bath of 5 h, standing for 1 to 1.5 h, and filtering to obtain filter residue 1;
(3) Uniformly mixing the filter residue 1 obtained in the step (2) with deionized water, wherein the mass volume ratio of the filter residue 1 to the deionized water is 1 g:10 mL, heating to 50-60 ℃, stirring at 180 rpm for 30 min, filtering to obtain filter residue 2, and drying the filter residue 2 at 70 ℃ to obtain volcanic rock-Ca (OH) 2 。
3. The hot pack according to claim 2, wherein the NaOH concentration of the NaOH and ethanol mixed solution in step (1) is 0.3 mol/L and the ethanol concentration is 80-90vol%.
4. A thermal pack containing volcanic rock according to claim 3 wherein said modified diatomaceous earth-CaO 2 The preparation method of (2) comprises the following steps:
I. ball milling diatomite, sieving with a 200-mesh sieve, soaking in a 30wt% NaCl solution for 1 h, heating to 80 ℃ and then continuously soaking for 2 h, wherein the mass-volume ratio of the diatomite to the NaCl solution is 1 g to 4 mL, cooling to 40 ℃, adding gelatin particles, wherein the mass ratio of the gelatin particles to the diatomite is 2:5, continuously stirring, heating to 60 ℃ at the speed of 2 ℃/min, continuously stirring for 30-40 min after reaching 60 ℃, filtering, washing with deionized water for 3 times, placing into a muffle furnace at 400 ℃ for calcining for 3-5 h, adding into a 10 mg/mL gentian acid solution, drying at 120 ℃, the solid-liquid ratio is 1 g to 2 mL, adding into a 4-carboxyl cinnamic acid solution at 0.1 mol/L, drying at 120 ℃, washing with deionized water, and drying at 60 ℃ to obtain modified diatomite;
Dissolving calcium peroxide in polyethylene glycol 400, wherein the mass volume ratio of the calcium peroxide to the polyethylene glycol 400 is 1 g to 15 mL, adding 0.3 mol/L hydrochloric acid solution, the volume ratio of the hydrochloric acid solution to the polyethylene glycol 400 is 2.5 to 1, stirring for 24: 24 h, centrifuging, washing the precipitate with absolute ethyl alcohol for three times, drying at normal temperature, adding absolute ethyl alcohol, the solid-liquid ratio is 4 mg to 5 mL, and carrying out ultrasonic treatment for 1-1.5: 1.5 h to obtain a mixed solution I;
III, immersing the modified diatomite obtained in the step I in the mixed solution I prepared in the step II, wherein the mass volume ratio of the modified diatomite to the mixed solution I is 1 g:20 mL, stirring for 30 min, heating to 80 ℃, preserving heat for 2-3 h, filtering, and vacuum drying at 60 ℃ to obtain the modified diatomite-CaO 2 。
5. The hot pack containing volcanic rock according to claim 4, wherein the preparation method of the herbal preparation comprises the following steps:
(a) Washing cortex Phellodendri, cortex Dictamni Radicis, fructus Cnidii, herba Sargassum, and folium Ilicis Purpureae, drying, mixing at a mass ratio of 1:2:2:1:3, pulverizing, sieving with 40 mesh sieve to obtain coarse powder of Chinese herbal medicine, adding 65vol% ethanol water solution, mixing coarse powder of Chinese herbal medicine with ethanol water solution at a mass ratio of 1:5, ultrasonic treating with 2 h, and filtering to obtain filtrate a and residue a;
(b) Regulating the pH value of the filtrate a obtained in the step (a) to 5-6 by using 0.1 mol/L citric acid-sodium citrate buffer solution, heating to 70-80 ℃, preserving heat for 2-3 h, cooling to room temperature, concentrating to 20% of the original volume at 60 ℃ and 0.1 MPa, and spray drying to obtain a product a;
(c) Drying the filter residue a obtained in the step (a) at 50 ℃, grinding, sieving with a 100-mesh sieve, adding into 0.1 mol/L acetic acid-sodium acetate buffer solution, wherein the mass volume ratio of the filter residue a to the acetic acid-sodium acetate buffer solution is 1 g:20 mL, adding cellulase, the mass ratio of the cellulase to the filter residue a is 1:2, centrifuging after constant-temperature water bath 48 and h at 40 ℃, washing the precipitate with deionized water for 3 times, freeze-drying, adding the precipitate and deionized water into a reaction kettle according to the mass ratio of 1:15, uniformly mixing, regulating the pH to 8-8.5 with sodium hydroxide, continuously stirring and heating to 90 ℃, adding 6-dimethylpyrimidine with the weight of the filter residue a to react for 1-2 h, cooling to room temperature, filtering, washing the precipitate with deionized water for 3 times, and drying at 50 ℃ to obtain a product b;
(d) And (3) uniformly mixing the product a obtained in the step (b) and the product b obtained in the step (c) according to the mass ratio of 2:1 to obtain the Chinese herbal medicine preparation.
6. The hot pack of claim 5, wherein the bioactive agent is prepared by a method comprising the steps of:
(i) Washing and drying enteromorpha, kelp and ulva, mixing according to the mass ratio of 1:2:1, crushing and sieving with a 80-mesh sieve to obtain seaweed powder, adding the seaweed powder into ultrapure water, uniformly mixing, placing the seaweed powder and the ultrapure water in a high-pressure sterilization pot 3-4 h with the mass volume ratio of 1 g:20 mL and the mass volume ratio of 0.15 MPa at 130 ℃, cooling to room temperature, adding p-hydroxybenzoic acid to the final concentration of 20 mmol/L, and stirring for 30 min to obtain a mixed solution i;
(ii) Adding 95vol% ethanol solution into the mixed solution i obtained in the step (i), wherein the volume-mass ratio of the ethanol solution to seaweed powder is 5 mL:1 g, refluxing for 2-3 h, filtering, adding 1 mol/L dipotassium hydrogen phosphate-potassium dihydrogen phosphate buffer solution into the precipitate, carrying out microwave extraction for 3 times, wherein the volume ratio of the dipotassium hydrogen phosphate-potassium dihydrogen phosphate buffer solution to the ethanol solution is 3:1, carrying out microwave power for 1700W at intervals of 5 min, wherein the extraction temperature is 80 ℃ each time, and filtering to obtain a precipitate to obtain a mixture ii;
(iii) Washing the mixture ii obtained in the step ii with deionized water for three times, uniformly mixing the mixture ii with deionized water, wherein the mass volume ratio of the mixture ii to the deionized water is 1 g to 12 mL, adding hydroquinone, the mass ratio of the hydroquinone to the mixture ii is 1 to 32, stirring at room temperature for 1-1.5 and h, filtering, drying at 55 ℃, grinding and sieving with a 500-mesh sieve to obtain the bioactive agent.
7. A method of preparing a volcanic-containing heat pack according to any one of claims 1-6, comprising the steps of:
s1: volcanic rock-Ca (OH) 2 Modified diatomite-CaO 2 Pulverizing Chinese herbal preparation, bioactive agent and stigmasterol, sieving with 80-100 mesh sieve, and mixing under nitrogen-filled environment to obtain mixture;
S2: uniformly spreading the mixture obtained in the step S1 on two pieces of breathable non-woven fabrics with the same size and the same material, reserving gaps of 1 cm around, covering the other piece of breathable non-woven fabrics relatively above, sealing four sides, and preserving in a dry and sealed environment to obtain a dressing bag;
s3: and (3) placing the dressing bag prepared in the step (S2) in the middle of the box body to obtain the hot compress bag containing volcanic rocks.
8. The thermal pack according to claim 7, wherein the mixture of step S2 is spread on the air-permeable non-woven fabric in an amount of 1 g/cm 2 The method comprises the steps of carrying out a first treatment on the surface of the The four-side sealing method can adopt a sewing or adhesive bonding method.
9. The thermal pack of claim 8 wherein the dressing is 50-60 cm a long and 4-7 cm a wide.
Priority Applications (1)
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