CN103223007B - Enuresis arresting ironing agent as well as preparation method and using method thereof - Google Patents
Enuresis arresting ironing agent as well as preparation method and using method thereof Download PDFInfo
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- CN103223007B CN103223007B CN201310188676.3A CN201310188676A CN103223007B CN 103223007 B CN103223007 B CN 103223007B CN 201310188676 A CN201310188676 A CN 201310188676A CN 103223007 B CN103223007 B CN 103223007B
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- 238000010409 ironing Methods 0.000 title claims abstract description 34
- 238000000034 method Methods 0.000 title claims abstract description 8
- 208000008967 Enuresis Diseases 0.000 title abstract description 8
- 238000002360 preparation method Methods 0.000 title abstract description 5
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 53
- 239000002994 raw material Substances 0.000 claims abstract description 39
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 36
- 238000010438 heat treatment Methods 0.000 claims abstract description 26
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims abstract description 22
- 239000011780 sodium chloride Substances 0.000 claims abstract description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000002023 wood Substances 0.000 claims abstract description 18
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000000843 powder Substances 0.000 claims description 20
- 229910052799 carbon Inorganic materials 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 7
- 241001446509 Psoralea Species 0.000 claims description 6
- 239000003814 drug Substances 0.000 abstract description 23
- 230000000694 effects Effects 0.000 abstract description 10
- 238000001467 acupuncture Methods 0.000 abstract description 6
- 229940079593 drug Drugs 0.000 abstract description 6
- 241000258241 Mantis Species 0.000 abstract description 4
- 239000002552 dosage form Substances 0.000 abstract description 4
- 230000002411 adverse Effects 0.000 abstract description 2
- 239000008280 blood Substances 0.000 abstract description 2
- 210000004369 blood Anatomy 0.000 abstract description 2
- 241000218671 Ephedra Species 0.000 abstract 1
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 235000013312 flour Nutrition 0.000 abstract 1
- 231100000956 nontoxicity Toxicity 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 8
- 229910052760 oxygen Inorganic materials 0.000 description 8
- 239000001301 oxygen Substances 0.000 description 8
- 238000007689 inspection Methods 0.000 description 6
- 230000035699 permeability Effects 0.000 description 6
- 230000002085 persistent effect Effects 0.000 description 6
- KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 description 4
- 210000003734 kidney Anatomy 0.000 description 4
- 229910052742 iron Inorganic materials 0.000 description 3
- 230000027939 micturition Effects 0.000 description 3
- 208000005346 nocturnal enuresis Diseases 0.000 description 3
- 206010002198 Anaphylactic reaction Diseases 0.000 description 2
- 206010041497 Spermatorrhoea Diseases 0.000 description 2
- 230000036783 anaphylactic response Effects 0.000 description 2
- 208000003455 anaphylaxis Diseases 0.000 description 2
- KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 description 2
- 229960002179 ephedrine Drugs 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 231100000957 no side effect Toxicity 0.000 description 2
- 230000003014 reinforcing effect Effects 0.000 description 2
- 210000003932 urinary bladder Anatomy 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 241000628927 Hierodula patellifera Species 0.000 description 1
- 241000258238 Mantidae Species 0.000 description 1
- 241000258239 Mantodea Species 0.000 description 1
- 206010059013 Nocturnal emission Diseases 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000007952 growth promoter Substances 0.000 description 1
- 239000002917 insecticide Substances 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 235000021374 legumes Nutrition 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000004630 mental health Effects 0.000 description 1
- 206010029446 nocturia Diseases 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 208000037920 primary disease Diseases 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 239000004576 sand Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 230000002618 waking effect Effects 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses an enuresis arresting ironing agent as well as a preparation method and a using method thereof. The enuresis arresting ironing agent comprises traditional Chinese medicine components and a self-heating agent, wherein the traditional Chinese medicine components comprise the following raw materials in parts by weight: 1-5 parts of ephedra, 5-15 parts of fructus psoraleae and 10-20 parts of mantis egg-case; and the self-heating agent comprises the following raw materials in parts by weight: 165-440 parts of iron powder, 60-160 parts of water, 18-48 parts of wood flour, 36-96 parts of activated carbon and 6-16 parts of sodium chloride. The enuresis arresting ironing agent disclosed by the invention is high-efficiency, safe and convenient to take, has no adverse side effect, achieves double treatment effects of medicines and acupuncture points and has the advantages of large drug-loading capacity, good compatibility with skin and strong appetency with medicines and the like; and the dosage form is accurate in dosage, has balance blood concentration without peak valley phenomenon, no toxicity, no stimulation and no allergy, alleviates the pain of child patients and has good child patient compliance.
Description
Technical field
The invention belongs to technical field of pharmaceuticals, especially relate to a kind of arresting enursis agent for ironing and preparation method thereof, using method.
Background technology
Bed-wetting is the common disease of department of pediatrics, and main clinical manifestation is: 5 years old above child, darker in the time of sleep, be difficult for waking up, oneself can not get up and urinate, the next day or wet the bed every night, an even nocturia bed several.The incidence rate of domestic 5～18 years old children and adolescents nocturnal enuresis is about 4%～9%, and it not only affects physical and mental health and the growth promoter of infant, has also increased the head of a family's spirit and living burden simultaneously.At present the treatment of primary disease is still lacked to efficient medicine both at home and abroad, this sick poor effect of western medicine; Though acupuncture effect is good, need repeatedly acupuncture, be difficult for being coordinated by most infants and accepting.Agent for ironing is a kind of dosage form of pharmacopeia, and existing medicine only has kanlisha coarse sand granules one.This research is a kind of agent for ironing that the applicable child that develops on this dosage form basis uses.
Summary of the invention
Arresting enursis agent for ironing that the technical problem to be solved in the present invention is to provide a kind of safe, good effect, has no side effect, avoids anaphylaxis, infant compliance is good and cost is low and preparation method thereof, using method.
Technical scheme of the present invention is a kind of arresting enursis agent for ironing, comprises Chinese medicinal components and self-generating exothermal agent, and described Chinese medicinal components comprises the raw material of following parts by weight,
1～5 part, Herba Ephedrae;
5～15 parts of Fructus Psoraleaes;
10～20 parts of Ootheca Mantidiss;
Wherein, described self-generating exothermal agent comprises the raw material of following parts by weight,
165～440 parts of iron powders;
60～160 parts, water;
18～48 parts of wood powders;
36～96 parts of active carbons;
6～16 parts, sodium chloride.
Preferably, described Chinese medicinal components comprises the raw material of following parts by weight,
2～4 parts, Herba Ephedrae;
8～12 parts of Fructus Psoraleaes;
13～17 parts of Ootheca Mantidiss;
Wherein, described self-generating exothermal agent comprises the raw material of following parts by weight,
253～363 parts of iron powders;
92～132 parts, water;
28～40 parts of wood powders;
55～79 parts of active carbons;
9～13 parts, sodium chloride.
Preferably, described Chinese medicinal components comprises the raw material of following parts by weight:
3 parts, Herba Ephedrae;
10 parts of Fructus Psoraleaes;
15 parts of Ootheca Mantidiss;
Wherein, described self-generating exothermal agent comprises the raw material of following parts by weight,
308 parts of iron powders;
112 parts, water;
37 parts of wood powders;
67 parts of active carbons;
11 parts, sodium chloride.
Preferably, the weight ratio of described Chinese medicinal components, iron powder, water, wood powder, active carbon and sodium chloride is 5:55:20:6:12:2.
The present invention also provides a kind of method of preparing arresting enursis agent for ironing as above, comprises the following steps,
1), take raw material Herba Ephedrae, Fructus Psoraleae and the Ootheca Mantidis of a certain amount of Chinese medicinal components;
2), the raw material in step 1) is directly pulverized, obtain Chinese medicinal components, then add iron powder, water, wood powder, active carbon and sodium chloride mix homogeneously, pack heating pad into.Heating pad is of a size of 50mm × 50mm, and heating pad temperature is controlled at below 50 DEG C, heating-up time≤10min, and temperature duration >=12h, temperature ensures 50% of time >=persistent period; Inner bag, outer bag intensity, sticking strength, oxygen permeability, all in strict conformity with medicine inspection intensity.
The present invention further provides a kind of method that uses arresting enursis agent for ironing as above, it is characterized in that: got infant Qihai, Guanyuan acupoint, arresting enursis agent for ironing is affixed on to the skin place at acupuncture point, every night once, paste 6～8h at every turn.
The principle of the medicine in the present invention: Herba Ephedrae, pungent, micro-hardship, temperature, returns lung, urinary bladder channel, in Herba Ephedrae, contain ephedrine, ephedrine can make trigone of bladder flesh and sphincteral tension force increase, and number of micturitions is reduced, when use amount is many, even cause urine retention, therefore demonstrate,prove for child enuresis.
Fructus Psoraleae is the fruit of annual herb legumes psoraleae.Nature and flavor with return through, warm in nature, acrid in the mouth, hardship.Reinforcing the kidney and supporting YANG, control the cold diarrhea of suffering from a deficiency of the kidney, the enuresis, spermatorrhea.
Mantis egg-case is the dry ootheca of Mantidae insecticide Chinese mantid, maculated mantis or hierodula patellifera or North China mantis.Nature and flavor with return through, property is sweet, salty in the mouth, flat.Return liver, kidney channel, controlling nocturnal emission with astringent drugs reducing urination, reinforcing the kidney and supporting YANG, cure mainly seminal emission, spermatorrhea, the enuresis, frequent micturition.
Arresting enursis agent for ironing of the present invention is that Chinese medicine and the iron powder described in more than one is primary raw material, there is oxidation exothermic reaction by contacting with airborne oxygen, can produce lasting and stable heat, by the method for thermal conductance, drug effect be played a role, act on human body particular acupoint and bring into play curative effect.
Feature of the present invention be (1) heating pad not directly and contact skin, avoided anaphylaxis generation; (2) heating pad in use medicine can entirety uniformly and oxygen react, avoided from inner bag aperture, oozing out pollution clothes after reactants dry, and it is dangerous to cause that child uses; (3) cost is low, has no side effect.
Advantage of the present invention and effect: highly effective and safe, taking convenience, pastes without the arresting enursis of adverse side effect is warm, not only reaches the double treatment effect at medicine and acupuncture point, and has kept its drug loading large, good with the compatibility of skin, with the advantage such as medicine affinity is strong; This dosage form dosage is accurate, and blood drug level balance is without peak valley phenomenon, nontoxic, non-stimulated, not irritated; Reduce infant misery, infant compliance is good.
Detailed description of the invention
In order to understand the present invention, below by specific embodiment, the invention will be further described.
Embodiment mono-
A kind of arresting enursis agent for ironing, is characterized in that: comprise Chinese medicinal components and self-generating exothermal agent, described Chinese medicinal components comprises the raw material of following parts by weight:
Herba Ephedrae 3g;
Fructus Psoraleae 10g;
Ootheca Mantidis 15g;
Wherein, described self-generating exothermal agent comprises the raw material of following parts by weight,
Iron powder 308g;
Water 112g;
Wood powder 33.6g;
Active carbon 67.2g;
Sodium chloride 11.2g.
Described arresting enursis agent for ironing is prepared by following steps:
1), take raw material 3g Herba Ephedrae, 10g Fructus Psoraleae and the 15g Ootheca Mantidis of Chinese medicinal components;
2), the raw material in step 1) is directly pulverized, obtain Chinese medicinal components, then add 308g iron powder, 112g water, 33.6g wood powder, 67.2g active carbon and 11.2g sodium chloride mix homogeneously, pack in heating pad, heating pad is of a size of 50mm × 50mm, and heating pad temperature is controlled at below 50 DEG C, heating-up time≤10min, temperature duration >=12h, temperature ensures 50% of time >=persistent period; Inner bag, outer bag intensity, sticking strength, oxygen permeability, all in strict conformity with medicine inspection requirement of strength.
Embodiment bis-
A kind of arresting enursis agent for ironing, is characterized in that: comprise Chinese medicinal components and self-generating exothermal agent, described Chinese medicinal components comprises the raw material of following parts by weight,
Herba Ephedrae 2g;
Fructus Psoraleae 7g;
Ootheca Mantidis 11g;
Wherein, described self-generating exothermal agent comprises the raw material of following parts by weight,
Iron powder 220g;
Water 80g;
Wood powder 24g;
Active carbon 48g;
Sodium chloride 8g.
Described arresting enursis agent for ironing is prepared by following steps:
1), take raw material 2g Herba Ephedrae, 7g Fructus Psoraleae and the 11g Ootheca Mantidis of Chinese medicinal components;
2), the raw material in step 1) is directly pulverized, obtain Chinese medicinal components, then add 220g iron powder, 80g water, 24g wood powder, 48g active carbon and 8g sodium chloride mix homogeneously, pack in heating pad, heating pad is of a size of 50mm × 50mm, and heating pad temperature is controlled at below 50 DEG C, heating-up time≤10min, temperature duration >=12h, temperature ensures 50% of time >=persistent period; Inner bag, outer bag intensity, sticking strength, oxygen permeability, all in strict conformity with medicine inspection requirement of strength.
Embodiment tri-
A kind of arresting enursis agent for ironing, is characterized in that: comprise Chinese medicinal components and self-generating exothermal agent, described Chinese medicinal components comprises the raw material of following parts by weight,
Herba Ephedrae 4g;
Fructus Psoraleae 11g;
Ootheca Mantidis 15g;
Wherein, described self-generating exothermal agent comprises the raw material of following parts by weight,
Iron powder 350g;
Water 120g;
Wood powder 38g;
Active carbon 68g;
Sodium chloride 11g.
Described arresting enursis agent for ironing is prepared by following steps:
1), take raw material 4g Herba Ephedrae, 11g Fructus Psoraleae and the 15g Ootheca Mantidis of Chinese medicinal components;
2), the raw material in step 1) is directly pulverized, obtain Chinese medicinal components, then add 350g iron powder, 120g water, 38g wood powder, 68g active carbon and 11g sodium chloride mix homogeneously, pack in heating pad, heating pad is of a size of 50mm × 50mm, and heating pad temperature is controlled at below 50 DEG C, heating-up time≤10min, temperature duration >=12h, temperature ensures 50% of time >=persistent period; Inner bag, outer bag intensity, sticking strength, oxygen permeability, all in strict conformity with medicine inspection requirement of strength.
Embodiment tetra-
A kind of arresting enursis agent for ironing, is characterized in that: comprise Chinese medicinal components and self-generating exothermal agent, described Chinese medicinal components comprises the raw material of following parts by weight,
Herba Ephedrae 4g;
Fructus Psoraleae 11g;
Ootheca Mantidis 15g;
Wherein, described self-generating exothermal agent comprises the raw material of following parts by weight,
Iron powder 330g;
Water 120g;
Wood powder 36g;
Active carbon 72g;
Sodium chloride 12g.
Described arresting enursis agent for ironing is prepared by following steps:
1), take raw material 4g Herba Ephedrae, 11g Fructus Psoraleae and the 15g Ootheca Mantidis of Chinese medicinal components;
2), the raw material in step 1) is directly pulverized, obtain Chinese medicinal components, then add 330g iron powder, 120g water, 36g wood powder, 72g active carbon and 12g sodium chloride mix homogeneously, pack in heating pad, heating pad is of a size of 50mm × 50mm, and heating pad temperature is controlled at below 50 DEG C, heating-up time≤10min, temperature duration >=12h, temperature ensures 50% of time >=persistent period; Inner bag, outer bag intensity, sticking strength, oxygen permeability, all in strict conformity with medicine inspection requirement of strength.
Embodiment five
A kind of arresting enursis agent for ironing, comprises Chinese medicinal components and self-generating exothermal agent, and described Chinese medicinal components comprises the raw material of following parts by weight,
Herba Ephedrae 1g;
Fructus Psoraleae 8g;
Ootheca Mantidis 13g;
Wherein, described self-generating exothermal agent comprises the raw material of following parts by weight,
Iron powder 298g;
Water 104g;
Wood powder 26g;
Active carbon 57g;
Sodium chloride 9g.
Described arresting enursis agent for ironing is prepared by following steps:
1), take raw material 1g Herba Ephedrae, 8g Fructus Psoraleae and the 13g Ootheca Mantidis of Chinese medicinal components;
2), the raw material in step 1) is directly pulverized, obtain Chinese medicinal components, then add 298g iron powder, 104g water, 26g wood powder, 57g active carbon and 9g sodium chloride mix homogeneously, pack in heating pad, heating pad is of a size of 50mm × 50mm, and heating pad temperature is controlled at below 50 DEG C, heating-up time≤10min, temperature duration >=12h, temperature ensures 50% of time >=persistent period; Inner bag, outer bag intensity, sticking strength, oxygen permeability, all in strict conformity with medicine inspection requirement of strength.
The agent for ironing heating pad of embodiment mono-～embodiment five is applied to respectively to 150 examples and suffers from the patient of bed-wetting, wherein 5～10 years old patient's 80 example, 10～14 years old patient's 60 examples, 14～18 years old patient's 10 examples, get infant Qihai, Guanyuan acupoint, arresting enursis agent for ironing is affixed on to the skin place at acupuncture point, every night once, each 6～8h that pastes, it within 4 weeks, is a course for the treatment of, wherein 5～10 years old each of patient need to paste agent for ironing heating pad, 10～14 years old and 14～18 years old patient need to paste two subsides agent for ironing heating pads at every turn, so that covering Qihai, Guanyuan acupoint, treat a course for the treatment of, the experimental result obtaining is as shown in Table 1 and Table 2:
Table 1
| ? | Recovery from illness number | Good revolution | Invalid number |
| Embodiment mono- | 55 | 94 | 1 |
| Embodiment bis- | 50 | 98 | 2 |
| Embodiment tri- | 50 | 97 | 3 |
| Embodiment tetra- | 53 | 95 | 2 |
| Embodiment five | 47 | 98 | 5 |
Table 2
| ? | Cure rate | Good revolution | Invalid number |
| 5～10 years old patients | 40% | 60% | 0 |
| 10～14 years old patients | 30% | 69% | 1% |
| 14～18 years old patients | 5% | 85% | 10% |
As can be seen from Table 2, agent for ironing of the present invention is better to 14 years old following patient's effect, general to more than 14 years old patient's therapeutic effect, need to assist other medicines to treat.
The present invention is not limited to above-mentioned preferred forms, and other any or akin products identical with the present invention that anyone draws under enlightenment of the present invention, within all dropping on protection scope of the present invention.
Claims (5)
1. an arresting enursis agent for ironing, is characterized in that: be made up of Chinese medicinal components and self-generating exothermal agent, described Chinese medicinal components is made up of the raw material of following parts by weight,
1～5 part, Herba Ephedrae;
5～15 parts of Fructus Psoraleaes;
10～20 parts of Ootheca Mantidiss;
Wherein, described self-generating exothermal agent is made up of the raw material of following parts by weight,
2. arresting enursis agent for ironing as claimed in claim 1, is characterized in that: described Chinese medicinal components is made up of the raw material of following parts by weight,
2～4 parts, Herba Ephedrae;
8～12 parts of Fructus Psoraleaes;
13～17 parts of Ootheca Mantidiss;
Wherein, described self-generating exothermal agent is made up of the raw material of following parts by weight,
3. arresting enursis agent for ironing as claimed in claim 1, is characterized in that: described Chinese medicinal components is made up of the raw material of following parts by weight:
3 parts, Herba Ephedrae;
10 parts of Fructus Psoraleaes;
15 parts of Ootheca Mantidiss;
Wherein, described self-generating exothermal agent is made up of the raw material of following parts by weight,
4. the arresting enursis agent for ironing as described in claim 1～3 any one, is characterized in that: the weight ratio of described Chinese medicinal components, iron powder, water, wood powder, active carbon and sodium chloride is 5:55:20:6:12:2.
5. a method of preparing the arresting enursis agent for ironing as described in any one in claim 1～4, is characterized in that: comprises the following steps,
1), take raw material Herba Ephedrae, Fructus Psoraleae and the Ootheca Mantidis of a certain amount of Chinese medicinal components;
2), by step 1) in raw material directly pulverize, obtain Chinese medicinal components, then add iron powder, water, wood powder, active carbon and sodium chloride mix homogeneously, pack heating pad into.
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Granted publication date: 20141203 |