CN1175770C

CN1175770C - Making process of active gauze mask capable of filtering out pathogenic microorganism

Info

Publication number: CN1175770C
Application number: CNB031190448A
Authority: CN
Inventors: 卢大炎
Original assignee: Wuhan Institute of Botany of CAS
Current assignee: Wuhan Botanical Garden of CAS
Priority date: 2003-05-08
Filing date: 2003-05-08
Publication date: 2004-11-17
Anticipated expiration: 2023-05-08
Also published as: CN1452922A

Abstract

The present invention discloses a method for making an active gauze mask capable of filtering out pathogenic microorganisms. Firstly, tannin solution is extracted from plants; secondly, cotton gauze is dipped in the solution and is used as a pathogenic microorganism filtering layer after being dried; thirdly, absolute alcohol solution of antisepsis essential oil is sprayed to the cotton gauze, and the cotton gauze is dried; finally, double layers of the cotton gauze with the essential oil are placed at one side of the middle part of a mask, and a tannin filtering layer is arranged at the other side. The present invention has the advantages of easy technology, low cost and innocuity and harmlessness and can effectively capture, kill and filter the pathogenic microorganisms, and the effective rate reaches more than 98%.

Description

A kind of preparation method who filters the active mouth mask of pathogenic microorganism

Technical field

The present invention relates to a kind of preparation method who filters the active mouth mask of pathogenic microorganism, this mouth mask is applicable to communicable disease area crowd, is particularly useful for being engaged in the personnel relevant with infective virus and uses.

Background technology

Enter respiratory system for preventing and treating extraneous harmful substance, increase the density of mouth mask filter course and the effect that thickness can improve dustproof filter, the employing that has static filter pulp (as the 3M protective mask), the employing that has activated carbon (respiratory resistance is big, can only adsorb lipophilic substance) wait other adsorbing medium to increase its adsorption capacity, also adsorbable part pernicious gas.The function of general medicated gauze mask can be divided into two kinds, a kind of is to be used for avoiding passive infection (FFP1, the FFP2 mouth mask that pass through as product N95 mouth mask and European Community's checking of U.S. Megatech Scientific Co., Ltd, but the shortcoming of this class mouth mask is can't avoid initiatively infecting); Another kind can avoid the carrier of disease to give other people (as the medical operation mouth mask) with viral communication.But these ways all can not be filtered the pathogenic microorganism of virus and so on effectively, and this is because the size of virus only has 20～30nm, and the aperture of micron order mouth mask is quite bigger by the probability in this aperture than the big thousands of times of pathogenic microorganisms of virus; Even if bacterium or virus can be stopped that because general mouth mask itself there is no sterilizing function, these bacteriums or virus still can be survived tens of hours even a few hours by mouth mask on mouth mask.

Summary of the invention

The object of the present invention is to provide a kind of preparation method who filters the active mouth mask of pathogenic microorganism, from plant, extract active component, technology is easy, extract is adsorbed on place on cotton gauze or the nonwoven in the middle of the mouth mask, can effectively capture, kill, filter pathogenic microorganism.

For achieving the above object, the present invention has adopted following technical measures: the function that only can block dust in view of common mouth mask, and general medicated gauze mask does not possess the selective filter pathogenic microorganism and breathing mask is not suitable for many weak points such as most of public situation uses, the present invention has avoided the discomfort of wearing that the compacted zone of the physics that designs by molecular size or mechanical filter causes, the unsafe factor of also having avoided the careless omission because of filter course to cause; Adverse factors such as side effect have also been avoided simultaneously because of adopting the chemical synthesis bactericide to be caused, the chemical reactive filtration method that designs according to the molecular characterization of pathogenic microorganism, can intercept and capture most of pathogenic microorganisms, play the unapproachable filter effect of common mouth mask; For the purpose of more safely, also, increased lipophilic essential oil stenlizing layer at the virus characteristic of band lipophilic protein shell.The active material of all filter courses and stenlizing layer is and adopts the refining effective ingredients in plant that forms of modern technologies, and the viruses molecule in a single day active component of contacted filtering layer is just crosslinked and be wrapped and make it inactivation with its generation multiple spot at once.

According to most of viruses the general character of protein coat is arranged all, vegatable tannin is can be in several seconds to two minute crosslinked and produce precipitation reaction with its generation multiple spot, at inactivation in 1～2 minute at the most.Through screening test, show that the tannin effect of granatum is remarkable; For killing the virus of band lipophilic protein adventitia, adopted sterilizing and anti-virus volatile oil based on the oriental wormwood and the capsule of weeping forsythia as second filter course, can play the economic benefits and social benefits effect of pathogenic microbe killing.

Its technical scheme is: the preparation medicated gauze mask at first is to extract tanning solution from plant, A, plant material is pulverized, and cleans impurity; B, lixiviate, 50-60 ℃ lixiviate 3-5 hour, filter; C, filtrate hydro-oxidation calcium solution, pH value is 10-11, makes the tannin precipitation; Water-solubility impurity is removed in D, filtration, precipitates twice with aqua calcis washing tannin; E, adding oxalic acid, PH 6-8 makes the tannin precipitation be converted into calcium oxalate precipitation, and makes tannin dissociate out; F, remove by filter calcium oxalate precipitation, tanning solution; Secondly cotton gauze is immersed in the tanning solution, dry back is a form pathogenic micro organism filtering layer, is the tannin filter course; Be that the absolute alcohol spray solution of antibacterial plant essential oil is dry on cotton gauze once more; The 4th is that plants essential oil cotton gauze bilayer is placed on the middle one side of mouth mask, and another side is placed the tannin filter course, makes pocket type so that change filter course, vacuum sealed package.

The present invention compared with prior art has the following advantages and effect: at first it is a kind of biofiltration mouth mask; The chemical reaction that is adopted is the general character that has protein coat at pathogenic microorganism, and most of pathogenic microorganisms (comprising variation) are all had combination.Intercepting and capturing filter course of the present invention adopts the vegatable tannin of molecular weight about 700～1000 to make compound, can make the pathogenic microorganism inactivation in several seconds to two minute, both can avoid passive infection, can avoid patient to give other people with viral communication again; The moisture of having breathed out in having utilized mouthful causes little wet environment to be beneficial to combining of tannin and pathogenic microorganism, and the carbon dioxide of breathing out in simultaneously mouthful can dissociate out to reach with the form of slowly-releasing and keep its activity of length the tannin in the compound.Thereafter one deck plant sterilization essential oil is arranged, further increased safety coefficient; With low cost, nontoxic free from extraneous odour.In addition, also added false proof indication composition in the prescription.

Its 1% aqueous solution of the vegatable tannin that the present invention relates to has proved to have strong people's external use effect of killing the virus; Make carrier (each 75cm with double gauze ²) aqueous solution of absorption 150mg tannin, after waiting to do, doing the virus simulation and capture test, the result shows: the carrier of no tannin is almost completely invalid, and the filtering layer that contains tannin reaches more than 98% the intercepting and capturing rate of simulated virus albumen.

The specific embodiment

The extracts active ingredients step that at first is resisting pathogenic microbes is as follows:

1. plant material is pulverized (raw material is granatum or garden burnet or nutgall), be crushed to 1 square centimeter, place nonmetallic vessel, after the running water rinsing, add running water and flood raw material;

2. lixiviate, 60 ℃ of lixiviates 4 hours are filtered, and repeat twice, merging filtrate;

3. adding saturated calcium hydroxide aqueous solution to pH value in filtrate is 10, makes the tannin precipitation;

4. filter,, reach and remove water-solubility impurity with aqua calcis washing tannin precipitation twice.

5. add 20% oxalic acid solution to PH be 7, filter, make the tannin precipitation be converted into calcium oxalate precipitation, and make tannin dissociate out;

6. remove by filter calcium oxalate precipitation, get tanning solution.

Next is that cotton filter cloth is immersed in the tanning solution, reaches every cm ²Absorption 0.5-1mg tannin, after the freeze drying as form pathogenic micro organism filtering layer.

The 3rd is 1 liter to be contained be sprayed on gauze or the nonwoven 70 ℃ of recovered under reduced pressure alcohol, drying after 0.1% antibacterial plant essential oil (capsule of weeping forsythia and oriental wormwood 1: 2) dilutes with absolute alcohol solution.

The 4th is to be placed on and to meet air surface in the middle of the mouth mask containing plants essential oil gauze bilayer, contains the tannin layer and is placed on thereafter, mouth mask is made pocket type so that change filter course, vacuum sealed package.

Claims

1, a kind of preparation method who filters the active mouth mask of pathogenic microorganism, it comprises the following steps:

A, extracting tanning solution from plant, at first is that plant material is pulverized, and cleans impurity; Next is lixiviate, 50-60 ℃ lixiviate 3-5 hour, filter; The 3rd is filtrate hydro-oxidation calcium solution, and pH value is 10-11, makes the tannin precipitation; The 4th is to filter, and removes water-solubility impurity, precipitates twice with aqua calcis washing tannin; The 5th is to add oxalic acid, and pH value is 6-8, makes the tannin precipitation be converted into calcium oxalate precipitation, makes tannin dissociate out; The 6th is to remove by filter calcium oxalate precipitation, gets tanning solution;

B, cotton filter cloth is immersed in the tanning solution, after the freeze drying as form pathogenic micro organism filtering layer;

C, the antibacterial plant essential oil is sprayed on the cotton gauze drying with after the absolute alcohol solution dilution;

D, plants essential oil cotton gauze bilayer is placed on one side in the middle of the mouth mask, another side is placed the tannin filter course, makes pocket type so that change filter course, vacuum sealed package.