CN117530885A - Mild water-oil double-layer cleansing lotion and preparation method thereof - Google Patents
Mild water-oil double-layer cleansing lotion and preparation method thereof Download PDFInfo
- Publication number
- CN117530885A CN117530885A CN202311629516.8A CN202311629516A CN117530885A CN 117530885 A CN117530885 A CN 117530885A CN 202311629516 A CN202311629516 A CN 202311629516A CN 117530885 A CN117530885 A CN 117530885A
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- Prior art keywords
- water
- oil
- poloxamer
- phase
- mass
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- 238000002360 preparation method Methods 0.000 title abstract description 13
- 239000006210 lotion Substances 0.000 title abstract description 6
- 239000012071 phase Substances 0.000 claims abstract description 119
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 63
- 229910001868 water Inorganic materials 0.000 claims abstract description 61
- -1 alkyl glucoside Chemical class 0.000 claims abstract description 48
- 239000004094 surface-active agent Substances 0.000 claims abstract description 47
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims abstract description 35
- 229930182478 glucoside Natural products 0.000 claims abstract description 35
- 239000007788 liquid Substances 0.000 claims abstract description 35
- 229920001983 poloxamer Polymers 0.000 claims abstract description 32
- 229960000502 poloxamer Drugs 0.000 claims abstract description 28
- 239000004519 grease Substances 0.000 claims abstract description 16
- 238000002156 mixing Methods 0.000 claims abstract description 16
- 229920002545 silicone oil Polymers 0.000 claims abstract description 14
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 12
- 239000008346 aqueous phase Substances 0.000 claims abstract description 11
- 150000001875 compounds Chemical class 0.000 claims abstract description 11
- 239000003755 preservative agent Substances 0.000 claims abstract description 10
- 230000002335 preservative effect Effects 0.000 claims abstract description 10
- 125000002091 cationic group Chemical group 0.000 claims abstract description 9
- JDRSMPFHFNXQRB-CMTNHCDUSA-N Decyl beta-D-threo-hexopyranoside Chemical compound CCCCCCCCCCO[C@@H]1O[C@H](CO)C(O)[C@H](O)C1O JDRSMPFHFNXQRB-CMTNHCDUSA-N 0.000 claims description 28
- 229940073499 decyl glucoside Drugs 0.000 claims description 28
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 27
- 229940116406 poloxamer 184 Drugs 0.000 claims description 27
- 239000000203 mixture Substances 0.000 claims description 17
- 239000000463 material Substances 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 12
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 claims description 12
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 10
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims description 10
- 239000008363 phosphate buffer Substances 0.000 claims description 9
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 7
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 7
- 239000002562 thickening agent Substances 0.000 claims description 7
- HMEKVHWROSNWPD-UHFFFAOYSA-N Erioglaucine A Chemical compound [NH4+].[NH4+].C=1C=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C(=CC=CC=2)S([O-])(=O)=O)C=CC=1N(CC)CC1=CC=CC(S([O-])(=O)=O)=C1 HMEKVHWROSNWPD-UHFFFAOYSA-N 0.000 claims description 6
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 claims description 6
- XJFGDLJQUJQUEI-UHFFFAOYSA-N dodecyl decanoate dodecyl octanoate Chemical compound CCCCCCCCCCCCOC(=O)CCCCCCC.CCCCCCCCCCCCOC(=O)CCCCCCCCC XJFGDLJQUJQUEI-UHFFFAOYSA-N 0.000 claims description 6
- 229910000160 potassium phosphate Inorganic materials 0.000 claims description 6
- 235000011009 potassium phosphates Nutrition 0.000 claims description 6
- GTJOHISYCKPIMT-UHFFFAOYSA-N 2-methylundecane Chemical compound CCCCCCCCCC(C)C GTJOHISYCKPIMT-UHFFFAOYSA-N 0.000 claims description 5
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims description 5
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims description 5
- SGVYKUFIHHTIFL-UHFFFAOYSA-N Isobutylhexyl Natural products CCCCCCCC(C)C SGVYKUFIHHTIFL-UHFFFAOYSA-N 0.000 claims description 5
- 229960000458 allantoin Drugs 0.000 claims description 5
- 238000011049 filling Methods 0.000 claims description 5
- VKPSKYDESGTTFR-UHFFFAOYSA-N isododecane Natural products CC(C)(C)CC(C)CC(C)(C)C VKPSKYDESGTTFR-UHFFFAOYSA-N 0.000 claims description 5
- 229940101267 panthenol Drugs 0.000 claims description 5
- 235000020957 pantothenol Nutrition 0.000 claims description 5
- 239000011619 pantothenol Substances 0.000 claims description 5
- 239000011780 sodium chloride Substances 0.000 claims description 5
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims description 4
- 229920001090 Polyaminopropyl biguanide Polymers 0.000 claims description 4
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 4
- 229940093424 polyaminopropyl biguanide Drugs 0.000 claims description 4
- 229940059958 centella asiatica extract Drugs 0.000 claims description 3
- 229920001993 poloxamer 188 Polymers 0.000 claims description 3
- 229940044519 poloxamer 188 Drugs 0.000 claims description 3
- 229940064064 purslane extract Drugs 0.000 claims description 3
- UIVPNOBLHXUKDX-UHFFFAOYSA-N 3,5,5-trimethylhexyl 3,5,5-trimethylhexanoate Chemical compound CC(C)(C)CC(C)CCOC(=O)CC(C)CC(C)(C)C UIVPNOBLHXUKDX-UHFFFAOYSA-N 0.000 claims description 2
- 229940123208 Biguanide Drugs 0.000 claims description 2
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 claims description 2
- 229920002507 Poloxamer 124 Polymers 0.000 claims description 2
- 229920002509 Poloxamer 182 Polymers 0.000 claims description 2
- 229920002511 Poloxamer 237 Polymers 0.000 claims description 2
- 229920002516 Poloxamer 331 Polymers 0.000 claims description 2
- 229920002517 Poloxamer 338 Polymers 0.000 claims description 2
- 229960001950 benzethonium chloride Drugs 0.000 claims description 2
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 claims description 2
- 229960002798 cetrimide Drugs 0.000 claims description 2
- 229940080421 coco glucoside Drugs 0.000 claims description 2
- XJNUECKWDBNFJV-UHFFFAOYSA-N hexadecyl 2-ethylhexanoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)C(CC)CCCC XJNUECKWDBNFJV-UHFFFAOYSA-N 0.000 claims description 2
- 229940100554 isononyl isononanoate Drugs 0.000 claims description 2
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 claims description 2
- PYIDGJJWBIBVIA-UYTYNIKBSA-N lauryl glucoside Chemical compound CCCCCCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O PYIDGJJWBIBVIA-UYTYNIKBSA-N 0.000 claims description 2
- 229940048848 lauryl glucoside Drugs 0.000 claims description 2
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims description 2
- 235000019341 magnesium sulphate Nutrition 0.000 claims description 2
- 229910000402 monopotassium phosphate Inorganic materials 0.000 claims description 2
- 235000019796 monopotassium phosphate Nutrition 0.000 claims description 2
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 claims description 2
- 229940093448 poloxamer 124 Drugs 0.000 claims description 2
- 229940093426 poloxamer 182 Drugs 0.000 claims description 2
- 229920001992 poloxamer 407 Polymers 0.000 claims description 2
- 229940044476 poloxamer 407 Drugs 0.000 claims description 2
- 229920002635 polyurethane Polymers 0.000 claims description 2
- 239000004814 polyurethane Substances 0.000 claims description 2
- 239000001103 potassium chloride Substances 0.000 claims description 2
- 235000011164 potassium chloride Nutrition 0.000 claims description 2
- 235000002639 sodium chloride Nutrition 0.000 claims description 2
- 239000010410 layer Substances 0.000 claims 10
- XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 claims 1
- 229940095082 c13-15 alkane Drugs 0.000 claims 1
- 239000002355 dual-layer Substances 0.000 claims 1
- 208000002193 Pain Diseases 0.000 abstract description 5
- 208000035620 Eye penetration Diseases 0.000 abstract description 4
- 210000003491 skin Anatomy 0.000 description 14
- 230000000052 comparative effect Effects 0.000 description 11
- 238000002474 experimental method Methods 0.000 description 10
- 238000003756 stirring Methods 0.000 description 9
- 238000013329 compounding Methods 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 239000002537 cosmetic Substances 0.000 description 4
- 230000032798 delamination Effects 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- 229910001220 stainless steel Inorganic materials 0.000 description 4
- 239000010935 stainless steel Substances 0.000 description 4
- 206010015958 Eye pain Diseases 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- QCYLIQBVLZBPNK-UHFFFAOYSA-N asiaticoside A Natural products O1C(C(=O)C(C)C)=CC(C)C(C2(C(OC(C)=O)CC34C5)C)C1CC2(C)C3CCC(C1(C)C)C45CCC1OC1OCC(O)C(O)C1O QCYLIQBVLZBPNK-UHFFFAOYSA-N 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- 210000004207 dermis Anatomy 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 230000005484 gravity Effects 0.000 description 2
- 210000002510 keratinocyte Anatomy 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 201000004569 Blindness Diseases 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 206010015946 Eye irritation Diseases 0.000 description 1
- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- WYQVAPGDARQUBT-FGWHUCSPSA-N Madecassol Chemical compound O([C@@H]1[C@@H](CO)O[C@H]([C@@H]([C@H]1O)O)OC[C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)OC(=O)[C@]12CC[C@H]([C@@H]([C@H]1C=1[C@@]([C@@]3(CC[C@H]4[C@](C)(CO)[C@@H](O)[C@H](O)C[C@]4(C)[C@H]3CC=1)C)(C)CC2)C)C)[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O WYQVAPGDARQUBT-FGWHUCSPSA-N 0.000 description 1
- BNMGUJRJUUDLHW-HCZMHFOYSA-N Madecassoside Chemical compound O([C@@H]1[C@@H](CO)O[C@H]([C@@H]([C@H]1O)O)OC[C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)OC(=O)[C@]12CC[C@H]([C@@H]([C@H]1C=1[C@@]([C@@]3(C[C@@H](O)[C@H]4[C@](C)(CO)[C@@H](O)[C@H](O)C[C@]4(C)[C@H]3CC=1)C)(C)CC2)C)C)[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O BNMGUJRJUUDLHW-HCZMHFOYSA-N 0.000 description 1
- BNMGUJRJUUDLHW-HLUHVYOBSA-N Madecassoside Natural products C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@H](O)[C@@](C)(CO)[C@@H]5[C@H](O)C[C@@]34C)[C@@H]2[C@H]1C)C(=O)O[C@@H]6O[C@H](CO[C@@H]7O[C@H](CO)[C@@H](O[C@@H]8O[C@H](C)[C@H](O)[C@@H](O)[C@H]8O)[C@H](O)[C@H]7O)[C@@H](O)[C@H](O)[C@H]6O BNMGUJRJUUDLHW-HLUHVYOBSA-N 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 150000001335 aliphatic alkanes Chemical class 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- FSLPMRQHCOLESF-SFMCKYFRSA-N alpha-amyrin Chemical group C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C)CC[C@@H](C)[C@H](C)[C@H]5C4=CC[C@@H]3[C@]21C FSLPMRQHCOLESF-SFMCKYFRSA-N 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- WYQVAPGDARQUBT-XCWYDTOWSA-N asiaticoside Natural products O=C(O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@H]2[C@H](O)[C@H](O)[C@H](O[C@H]3[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O3)[C@@H](CO)O2)O1)[C@@]12[C@@H]([C@@H](C)[C@H](C)CC1)C=1[C@](C)([C@@]3(C)[C@@H]([C@@]4(C)[C@H]([C@@](CO)(C)[C@@H](O)[C@H](O)C4)CC3)CC=1)CC2 WYQVAPGDARQUBT-XCWYDTOWSA-N 0.000 description 1
- 229940022757 asiaticoside Drugs 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 150000004283 biguanides Chemical class 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000005238 degreasing Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- SNRUBQQJIBEYMU-UHFFFAOYSA-N dodecane Chemical class CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 239000003889 eye drop Substances 0.000 description 1
- 231100000013 eye irritation Toxicity 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002212 flavone derivatives Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 238000009499 grossing Methods 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000002563 ionic surfactant Substances 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 229940090813 madecassoside Drugs 0.000 description 1
- 239000000693 micelle Substances 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 230000005808 skin problem Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 150000003648 triterpenes Chemical class 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/03—Liquid compositions with two or more distinct layers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/604—Alkylpolyglycosides; Derivatives thereof, e.g. esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
- A61Q1/14—Preparations for removing make-up
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/596—Mixtures of surface active compounds
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Cosmetics (AREA)
Abstract
The application provides a mild water-oil double-layer cleansing lotion and a preparation method thereof, wherein the cleansing lotion comprises the following components: 25% -35% of oil phase and 65% -75% of water phase; the oil phase comprises: 20% -30% of synthetic polar grease; 30% -40% of light silicone oil; 30% -40% of nonpolar volatile isoparaffin; the aqueous phase comprises: 0.01% -0.5% of a soothing agent; 0.01% -0.3% of cationic preservative; 0.19% -0.6% of surfactant; the surfactant comprises alkyl glucoside and poloxamer. The water-oil double-layer cleansing liquid has the advantages that the surfactant with the mass content of 0.19-0.6% is added, so that the problem of eye penetration and stinging caused by the excessive content is avoided; through the compound use of the alkyl glucoside and the poloxamer, the water-oil double-layer cleansing liquid has the advantages of transparent water phase, proper layering time, uniform mixing of water and oil, clear layering and no emulsified phase.
Description
Technical Field
The application belongs to the field of cosmetics, and particularly relates to a mild water-oil double-layer cleansing liquid and a preparation method thereof.
Background
After using the makeup such as eye shadow and lipstick, the consumer can clean the makeup by using the makeup removing product. If the consumer cleans incompletely or the cleaning mode is wrong, the residual cosmetics can cause a series of skin problems. The water-oil double-layer cleansing liquid is deeply favored by consumers due to the advantages of mild system, fresh skin feel, convenient use and the like.
The existing water-oil double-layer cleansing liquid has the problems of slow cleansing, eye penetration and stinging, slow layering, easy wall hanging, easy occurrence of third phase, unclear layering limit, greasiness or tightness after removal and the like.
Disclosure of Invention
The application provides a mild water-oil double-layer cleansing liquid and a preparation method thereof, which can avoid the problem of eye penetration and pain, and ensure that a water phase material body is transparent, the layering time is proper, the water-oil is uniformly mixed, the layering is clear, and an emulsified phase is not generated.
According to a first aspect of the application, there is provided a water-oil double-layer makeup remover, comprising, in mass percent: 25% -35% of oil phase and 65% -75% of water phase;
the oil phase comprises the following components in percentage by mass:
20% -30% of synthetic polar grease;
30% -40% of light silicone oil;
30% -40% of nonpolar volatile isoparaffin;
the water phase comprises the following components in percentage by mass:
wherein the compound surfactant comprises alkyl glucoside and poloxamer.
In any embodiment herein, the alkyl glucoside is a C12-C20 alkyl glucoside.
Preferably, the alkyl glucosides include at least one of octyl/decyl glucoside, coco glucoside, lauryl glucoside.
In any embodiment of the present application, the poloxamer comprises at least one of poloxamer 101, poloxamer 124, poloxamer 182, poloxamer 184, poloxamer 188, poloxamer 237, poloxamer 331, poloxamer 338, poloxamer 407.
In any embodiment of the present application, the mass percent of alkyl glucoside to poloxamer is (14-50): 5, a step of;
alkyl glucosides are calculated as the mass of octyl/decyl glucoside and poloxamers are calculated as the mass of poloxamer 184.
In any embodiment of the application, the water-oil double-layer makeup remover comprises 28-32% of oil phase and 68-72% of water phase in percentage by mass;
the oil phase comprises the following components in percentage by mass:
23% -28% of synthetic polar grease;
35% -38% of light silicone oil;
35% -38% of nonpolar volatile isoparaffin;
the water phase comprises the following components in percentage by mass:
wherein the compound surfactant comprises alkyl glucoside and poloxamer.
In any embodiment of the present application, the mass percent of alkyl glucoside to poloxamer is (18-30): 5, a step of;
alkyl glucosides are calculated as the mass of octyl/decyl glucoside and poloxamers are calculated as the mass of poloxamer 184.
In any embodiment herein, the synthetic polar oil and fat comprises at least one of coco-caprylate/caprate, isopropyl palmitate, cetyl ethyl hexanoate, isononyl isononanoate.
In any embodiment of the present application, the light silicone oil comprises at least one of polydimethylsiloxane, octylpolydimethylsiloxane, cyclopentadimethylsiloxane.
In any embodiment herein, the non-polar volatile isoparaffin comprises at least one of the isomeric dodecanes, C13-15 alkanes.
In any embodiment of the present application, the soothing agent comprises at least one of allantoin, panthenol, purslane extract, centella asiatica extract.
In any embodiment of the present application, the cationic preservative comprises at least one of polyaminopropyl biguanide, cetrimide, benzethonium chloride.
In any embodiment of the present application, the phosphate buffer pair comprises at least two of potassium phosphate, dipotassium hydrogen phosphate, potassium dihydrogen phosphate.
In any embodiment of the present application, the water-soluble toner includes at least one of CI42090, CI17200, CI 19140.
In any embodiment of the present application, the thickener comprises at least one of sodium chloride, magnesium sulfate, potassium chloride.
In any embodiment of the present application, the complex surfactant is octyl/decyl glucoside and poloxamer 184.
In any embodiment herein, the oil phase comprises coco-caprylate/caprate, polydimethylsiloxane, and isododecane.
In any embodiment of the present application, the aqueous phase comprises allantoin, panthenol, polyurethane biguanides, octyl/decyl glucoside, poloxamer 184, CI42090, potassium phosphate, dipotassium hydrogen phosphate, sodium chloride, and water.
In any embodiment herein, the pH of the aqueous phase is from 6.5 to 7.1.
According to a second aspect of the application, a preparation method of a water-oil double-layer cleansing liquid is provided, which comprises the following steps:
mixing materials containing synthetic polar oil, light silicone oil and nonpolar volatile isoparaffin to obtain an oil phase;
mixing materials II containing a thickening agent, water and a soothing agent to obtain a phase A;
adding a material containing a soothing agent, a cationic preservative, alkyl glucoside, poloxamer, water-soluble toner and phosphate buffer pair into the phase A for mixing III to obtain a water phase;
and filling the materials containing the oil phase and the water phase to obtain the water-oil double-layer cleansing liquid.
In any embodiment of the present application, mix I, mix II, mix III are independently selected from the following conditions:
the rotating speed is 250-350rpm;
the time is 3-7min.
In any embodiment of the present application, the temperature of mixture II is 75-85 ℃.
In any embodiment of the present application, the temperature of mixture III is 20-45 ℃.
The mild water-oil double-layer cleansing lotion and the preparation method thereof avoid the problem of eye penetration and stinging caused by overhigh content by adding 0.19 to 0.6 mass percent of surfactant; through the compound use of the alkyl glucoside and the poloxamer, the water-oil double-layer cleansing liquid has the advantages of transparent water phase, proper layering time, uniform mixing of water and oil, clear layering and no emulsified phase.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings that are needed in the embodiments of the present application will be briefly described, and it is possible for a person skilled in the art to obtain other drawings according to these drawings without inventive effort.
Fig. 1 is a photograph of a water-oil double-layer makeup remover prepared in example 1 of the present application.
Fig. 2 is a photograph of the water-oil double-layer makeup remover of fig. 1 after shaking uniformly.
Fig. 3 is a photograph of skin after makeup is applied.
Fig. 4 is a photograph of skin after makeup removal of fig. 3 using the water-oil double-layer makeup remover prepared in example 1 of the present application, wherein area a is a photograph of skin after makeup removal using the water-oil double-layer makeup remover, and area b is a photograph of skin after makeup removal using the water-oil double-layer makeup remover.
Detailed Description
In order that the above objects, features and advantages of the present application may be more clearly understood, a further description of the aspects of the present application will be provided below. It should be noted that, in the case of no conflict, the embodiments of the present application and the features in the embodiments may be combined with each other.
In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present disclosure, but the present application may be practiced otherwise than as described herein; it will be apparent that the embodiments in the specification are only some, but not all, embodiments of the application.
Hereinafter, embodiments of a mild water-oil double-layer cleansing lotion and a preparation method thereof according to the present application will be specifically disclosed with reference to the accompanying drawings. However, unnecessary detailed description may be omitted. For example, detailed descriptions of well-known matters and repeated descriptions of the actual same structure may be omitted. This is to avoid that the following description becomes unnecessarily lengthy, facilitating the understanding of those skilled in the art. Furthermore, the drawings and the following description are provided for a full understanding of the present application by those skilled in the art, and are not intended to limit the subject matter recited in the claims.
The "range" disclosed herein is defined in terms of lower and upper limits, with a given range being defined by the selection of a lower and an upper limit, the selected lower and upper limits defining the boundaries of the particular range. Ranges that are defined in this way can be inclusive or exclusive of the endpoints, and any combination can be made, i.e., any lower limit can be combined with any upper limit to form a range. For example, if ranges of 60-120 and 80-110 are listed for a particular parameter, it is understood that ranges of 60-110 and 80-120 are also contemplated. Furthermore, if the minimum range values 1 and 2 are listed, and if the maximum range values 3,4 and 5 are listed, the following ranges are all contemplated: 1-3, 1-4, 1-5, 2-3, 2-4 and 2-5. In this application, unless otherwise indicated, the numerical range "a-b" represents a shorthand representation of any combination of real numbers between a and b, where a and b are both real numbers. For example, the numerical range "0-5" means that all real numbers between "0-5" have been listed throughout, and "0-5" is simply a shorthand representation of a combination of these values. When a certain parameter is expressed as an integer of 2 or more, it is disclosed that the parameter is, for example, an integer of 2, 3,4, 5, 6, 7, 8, 9, 10, 11, 12 or the like.
All embodiments and alternative embodiments of the present application may be combined with each other to form new solutions, and such solutions should be considered to be included in the disclosure of the present application, unless specifically stated otherwise.
All technical features and optional technical features of the present application may be combined with each other to form new technical solutions, if not specifically stated, and such technical solutions should be considered as included in the disclosure of the present application.
All steps of the present application may be performed sequentially or randomly, preferably sequentially, unless otherwise indicated. For example, the method comprises steps (a) and (b), meaning that the method may comprise steps (a) and (b) performed sequentially, or may comprise steps (b) and (a) performed sequentially. For example, the method may further include step (c), which means that step (c) may be added to the method in any order, for example, the method may include steps (a), (b) and (c), may include steps (a), (c) and (b), may include steps (c), (a) and (b), and the like.
In the existing water-oil double-layer cleansing liquid, a surfactant or a non-alkyl glucoside is usually used for compounding with a plurality of surfactants of non-poloxamer, so that the addition amount of the surfactant needs to be increased in order to better mix the components of the cleansing liquid. Excessive surfactant may cause a third phase to occur due to excessive emulsification, which may slow down the layering. Therefore, it is difficult to balance the uniform mixing of the cleansing liquid and the absence of the third phase in the prior art.
Improper surfactant selection can cause ocular stinging. Ionic surfactants ionize in aqueous solutions and produce positively or negatively charged ions that can cause ocular stinging.
The surfactant is an amphiphilic molecule with hydrophilic groups and lipophilic groups, the hydrophilic groups of the surfactant are easy to combine with water according to a similar compatibility principle, the lipophilic groups are combined with grease such as makeup dirt on the skin surface, and meanwhile, under the action of makeup removing auxiliary tools such as makeup removing cotton, one part of the makeup dirt is removed along with friction force, and the other part of the dirt is wrapped in a micelle structure and is taken away under the flushing of the water. When the surfactant and the grease are selected improperly, the water phase and the oil phase are easy to emulsify after shaking in the presence of the surfactant, the emulsifying layer is not disappeared after standing, and the problems of unclear third phase and layering limit occur.
In the water-oil double-layer cleansing liquid, if the water-oil ratio is improperly adjusted and the oil phase ratio is higher, the residual feeling and the greasy feeling are increased, and secondary cleaning is needed; when the specific gravity of the water phase is smaller, the density difference between the water phase and the oil phase becomes smaller, and the mixed water and oil phase can be slowly layered after shaking in the presence of a high-content surfactant.
The oil molecular structure has a larger difference with that of the oil used by the makeup product, and the double-layer makeup remover and the makeup product have slow permeation and poor compatibility, so that the makeup dissolution is slow. When the grease is not selected, for example, the condition that the residual sense and the greasy sense are relatively high occurs when the thicker grease is selected, and the secondary cleaning is needed; for example, the skin becomes taut and dry due to degreasing caused by the selection of the high-volatility grease.
Therefore, the application discloses a water-oil double-layer cleansing liquid, which can avoid the problem of eye pricking; the water-oil double-layer cleansing liquid has the advantages of transparent water phase, proper layering time, uniform water-oil mixing, clear layering and no emulsified phase.
Water-oil double-layer cleansing liquid
The first aspect of the embodiment of the application provides a water-oil double-layer makeup remover, which comprises the following components in percentage by mass: 25% -35% of oil phase and 65% -75% of water phase;
the oil phase comprises the following components in percentage by mass:
20% -30% of synthetic polar grease;
30% -40% of light silicone oil;
30% -40% of nonpolar volatile isoparaffin;
the water phase comprises the following components in percentage by mass:
wherein the compound surfactant comprises alkyl glucoside and poloxamer.
According to the application, after multiple experimental tests, when poloxamer is singly used, even under the condition of low content such as 0.05%, after the makeup remover is shaken at room temperature and is kept stand, the problems of unclear layering limit and existence of white substances can occur at a water-oil interface; when the alkyl glucoside is used alone, even if the content is low, such as 0.15%, the problem that the delamination is too fast occurs at the water-oil interface after the makeup remover is shaken at room temperature and is kept stand, and when the content of the alkyl glucoside is less than 0.14%, the problem that the water phase is opaque and frosted occurs. The appearance of the third phase in the cleansing liquid and the uniform mixing of the components are determined by the types and the addition amounts of the surfactants, and the influence of the types and the addition amounts of the surfactants on the cleansing liquid is not linearly changed.
The application adopts two nonionic surfactants to be compounded, so that the stinging feeling of eyes caused by ionization of the surfactants can be avoided as much as possible.
The application adopts 25% -35% of oil phase and 65% -75% of water phase, so that the residual feeling and the greasy feeling can be reduced, and the speed of the water-oil separation layer can be improved.
The oil phase formula is selected from mixed grease of synthetic polar grease, light silicone oil and nonpolar volatile isoparaffin, so that the color cosmetic product is better dissolved. The oil phase formula dissolves the makeup product by a similar compatibility principle, wherein the similarity means that the solute and the solvent are similar in structure, and the compatibility means that the solute and the solvent are mutually dissolved, so that the makeup similar to the structure can be dissolved by grease.
The water phase formula is prepared by selecting 0.5-1% of thickener to increase specific gravity of water and increase layering speed.
The cationic preservative is selected from the aqueous phase formulation in an amount of 0.01-0.3% to inhibit microbial growth.
The water-soluble toner is selected from the water phase formula to adjust the color of the water phase formula, so that a user can better judge whether the water-oil two phases are better mixed or not when the water-oil two-phase mixer is used. The water-soluble toner may be CI42090 at a concentration of 0.5%, wherein the solvent is deionized water.
Phosphate buffer pairs were selected in the aqueous phase formulation to adjust the aqueous phase pH. Phosphate buffer may be 1% potassium phosphate and 1% dipotassium hydrogen phosphate, wherein the solvent is deionized water.
According to the application, the water phase material is transparent through compounding of the synthetic polar grease, the light silicone oil and the nonpolar volatile isoparaffin and the compound surfactant, and layering is clear after standing, so that an emulsified phase is not generated.
In some embodiments, the mass percent of alkyl glucoside to poloxamer is (14-50): 5.
in some embodiments, the mass percent of alkyl glucoside to poloxamer is (18-30): 5.
in some embodiments, the mass percent of alkyl glucoside to poloxamer is (18-24): 5.
in some embodiments, the mass percent of alkyl glucoside to poloxamer is 21:5.
if the mass ratio of alkyl glucoside to poloxamer is lower than 14:5, the water phase becomes turbid and opaque; the mass ratio of the alkyl glucoside to the poloxamer is lower than 21: at 10, the cleansing liquid can be stabbed when entering eyes, and the third phase is easy to appear when the boundary of the water-oil layer is not clear.
In some embodiments, the soothing agent is selected from a combination of one to two, increasing the suitability of the formulation. Wherein, the purslane extract contains natural active ingredients such as flavone, saponin, alkaloid, polysaccharide and the like, can inhibit the apoptosis of keratinocytes and fibroblasts, has the functions of reversing the differentiation of the keratinocytes, protecting the skin cells of a human body from being damaged by cells induced by ultraviolet rays, and playing roles in relieving and repairing the barrier function of the skin; centella asiatica extract contains various triterpenes, which contain alpha-amyrin structure. The main components are asiaticoside and madecassoside, which can tighten the connection part of epidermis and dermis, soften skin, help to solve the phenomenon of skin relaxation and make skin smooth and elastic; helps promote collagen formation in the dermis layer, regenerates fibrin, connects again, and achieves the effect of tightening and smoothing skin. Can also help the healing of damaged tissues and tighten the skin.
In some embodiments, the cationic preservative is selected to be an added preservative component in an eye drop, such as a polyaminopropyl biguanide, to avoid ocular stinging.
In some embodiments, the oil phase is selected from the group consisting of coco-caprylate/caprate, polydimethylsiloxane and isododecane, and can be quickly dissolved and dispersed with the grease with different properties in the color cosmetic product without bringing greasy and smoldering skin feel to users.
In some embodiments, the aqueous phase pH is adjusted to 6.5-7.1. The phosphate buffer pair is selected to regulate the pH value, so that the pH value of the formula can be stabilized, and the water phase can be close to the pH value of human tear on the basis of adding a very small amount of pH regulator, thereby avoiding eye irritation.
Preparation method of water-oil double-layer cleansing liquid
The second aspect of the embodiment of the application provides a preparation method of a water-oil double-layer cleansing liquid, which comprises the following steps:
mixing materials containing synthetic polar oil, light silicone oil and nonpolar volatile isoparaffin to obtain an oil phase;
mixing materials II containing a thickening agent, water and a soothing agent to obtain a phase A;
adding a material containing a soothing agent, a cationic preservative, alkyl glucoside, poloxamer, water-soluble toner and phosphate buffer pair into the phase A for mixing III to obtain a water phase;
and filling the materials containing the oil phase and the water phase to obtain the water-oil double-layer cleansing liquid.
In some embodiments, when obtaining the oil phase, sequentially adding the synthetic polar oil, the light silicone oil and the nonpolar volatile isoparaffin into a stainless steel barrel, and stirring to obtain the oil phase.
In some embodiments, when phase A is obtained, the thickener, water, and a soothing agent are added sequentially into a stainless steel barrel, heated in a water bath at 75-85deg.C, and stirred until the solution is clear and transparent to obtain phase A.
In some embodiments, the A phase is cooled to below 45 ℃, and then another soothing agent and cationic preservative are added into the A phase and stirred uniformly; then adding alkyl glucoside and poloxamer into the phase A, and uniformly stirring; then adding the water-soluble toner into the phase A, and uniformly stirring to adjust the color of the phase A material; adding phosphate buffer pair into the phase A, stirring uniformly, adjusting the pH value of the water phase, supplementing water to 100%, and continuing stirring and mixing uniformly; and finally, filtering the phase A through a 300-mesh filter screen to obtain a water phase.
In some embodiments, the water phase and the oil phase are subjected to filling treatment to obtain the water-oil double-layer makeup remover.
Examples
The following examples more particularly describe the disclosure of the present application, which are intended as illustrative only, since numerous modifications and variations within the scope of the disclosure will be apparent to those skilled in the art. Unless otherwise indicated, all parts, percentages and ratios reported in the examples below are on a mass basis, and all reagents used in the examples are commercially available or were obtained synthetically according to conventional methods and can be used directly without further treatment, as well as the instruments used in the examples.
Example 1
Preparation of an oil phase:
25g of coco-caprylate/caprate, 37.5g of polydimethylsiloxane and 37.5g of isododecane were sequentially added into a stainless steel drum, and stirred at 300rpm for 5min to obtain an oil phase.
Preparation of an aqueous phase:
sequentially adding 0.9g of sodium chloride, 0.05g of allantoin and 95g of water into a stainless steel barrel, heating in a water bath at 80 ℃, and stirring at 300rpm for 3min to obtain a phase A;
cooling phase A to 30deg.C, adding 0.11g of panthenol and 0.28g of polyaminopropyl biguanide into phase A, stirring at 300rpm for 3min to obtain phase A 1 A phase;
0.21g of octyl/decyl glucoside, 0.05g of poloxamer 184 are added to A 1 In the phase, stirring at 300rpm for 3min to obtain A 2 A phase;
0.0175g of CI42090 was added to A 2 In the phase, stirring at 300rpm for 3min to obtain A 3 A phase;
0.006g of potassium phosphate and 0.004g of dipotassium hydrogen phosphate are added into A 3 In phase, adjust A 3 The pH value of the phase is between 6.5 and 7.1, after water is added to 100 percent, the mixture is stirred for 3 minutes at 300rpm, and a water phase is obtained after the mixture is filtered by a 300-mesh filter screen.
Preparation of water-oil double-layer cleansing liquid:
and (3) filling 70% of water phase and 30% of oil phase to obtain the water-oil double-layer cleansing liquid.
Example 2
Experimental procedure the procedure was as in example 1, except that the addition amount of octyl/decyl glucoside was changed to 0.336g and the addition amount of poloxamer 184 was changed to 0.08g, to obtain a water-oil double-layer cleansing liquid.
Example 3
Experimental procedure the procedure was as in example 1, except that the addition amount of octyl/decyl glucoside was changed to 0.42g and the addition amount of poloxamer 184 was changed to 0.1g, to obtain a water-oil double-layer cleansing liquid.
Comparative example 1
Experimental procedure the same as in example 1, the kind of the compound surfactant was changed, and octyl/decyl glucoside was changed to decyl glucoside and poloxamer 184 was changed to poloxamer 188, to obtain a water-oil double-layer cleansing liquid.
Comparative example 2
Experimental procedure the same as in example 1, the kind of the compound surfactant was changed only, and the combination of octyl/decyl glucoside/water and poloxamer 184 was changed to the combination of decyl glucoside and poloxamer 184, so as to obtain a water-oil double-layer cleansing liquid.
Comparative example 3
Experimental procedure the same as in example 1, the water-oil double-layer cleansing liquid was obtained by changing the ratio of the complex surfactant in the system to 0.052%, wherein the octyl/decyl glucoside is 0.042g and the poloxamer 184 is 0.01 g.
Comparative example 4
Experimental procedure the same as in example 1, the water-oil double-layer cleansing liquid was obtained by changing the ratio of the complex surfactant in the system to 0.78%, wherein the octyl/decyl glucoside is 0.63g and the poloxamer 184 is 0.15 g.
Comparative example 5
Experimental procedure As in example 1, only 0.05g of poloxamer 184 was used alone as the surfactant, and the added amount of poloxamer 184 was 0.05% at this time, to obtain a water-oil double-layer cleansing liquid.
Comparative example 6
Experimental procedure As in example 1, only 0.1g of poloxamer 184 was used alone as the surfactant, and the added amount of poloxamer 184 was 0.1% at this time, to obtain a water-oil double-layer cleansing liquid.
Comparative example 7
Experimental procedure As in example 1, only 0.21g of octyl/decyl glucoside alone was used as a surfactant, and the amount of octyl/decyl glucoside added at this time was 0.21%, to obtain a water-oil double-layer makeup remover.
Comparative example 8
Experimental procedure As in example 1, only 0.05g of octyl/decyl glucoside was used alone as a surfactant, and the amount of octyl/decyl glucoside added was 0.05%, to obtain a water-oil double-layer makeup remover.
Data testing
Performance evaluation was performed on the water-oil double-layer makeup remover prepared in examples 1 to 3 and comparative examples 1 to 8, and the evaluation results are shown in the following table:
as can be seen from example 1 and comparative example 1, when two surfactants were used in combination and non-octyl/decyl glucoside was combined with non-poloxamer 184, a third phase was likely to appear on standing after shaking at room temperature.
As can be seen from examples 1 and 2, when two surfactants are used for compounding and non-octyl/decyl glucoside is compounded with poloxamer 184, a third phase is likely to appear after shaking at room temperature.
As is clear from the results of examples 1 and 3, when two surfactants were used for compounding and octyl/decyl glucoside and poloxamer 184 were compounded, when the content of the mixed surfactant was less than 0.19%, problems of serious wall sticking, uneven water-oil mixing and water-phase development occurred in the mixture after shaking at room temperature, and water-oil boundary lines close to 3:7 occurred in 60 seconds of delamination.
As is clear from examples 1 and 4, when two surfactants were used for the compounding, and the content of the mixed surfactant was higher than 0.6%, the mixed surfactant was used after shaking at room temperature, and the problem of blindness and unclear delamination after standing was found.
As is clear from examples 1 and 5, when a single surfactant (0.05% of the amount of the surfactant) was used and poloxamer 184 was used, the boundary of delamination was not clear and white substances were present at the interface when left standing after shaking at room temperature, i.e., the third phase was present.
As is clear from examples 1 and 7, when a single surfactant (0.21% of the amount added) was used and octyl/decyl glucoside was used, the water phase did not develop, but the oil/water separation was too fast.
As is clear from examples 1 and 8, when a single surfactant (0.05% of the amount of the surfactant) was used, the oil and water layers were too fast, the oil and water were not easily mixed uniformly, and the water phase was clouded.
As is clear from comparative examples 5 to 8, when octyl/decyl glucoside or poloxamer 184 is used alone, the amount of the additive does not linearly change with whether the aqueous phase is frosted or not, and the third phase and the water-oil layer are too fast, because the compounding type of the surfactant and the content of the surfactant in the cleansing liquid affect whether the aqueous phase is frosted or not, and the third phase and the water-oil layer are too fast.
In the foregoing, only the specific embodiments of the present application are described, and it will be clearly understood by those skilled in the art that, for convenience and brevity of description, the specific working processes of the systems, modules and units described above may refer to the corresponding processes in the foregoing method embodiments, which are not repeated herein. It should be understood that the scope of the present application is not limited thereto, and any person skilled in the art can easily conceive various equivalent modifications or substitutions within the technical scope of the present application, which are intended to be included in the scope of the present application.
Claims (10)
1. The water-oil double-layer makeup remover is characterized by comprising the following components in percentage by mass: 25% -35% of oil phase and 65% -75% of water phase;
the oil phase comprises the following components in percentage by mass:
20% -30% of synthetic polar grease;
30% -40% of light silicone oil;
30% -40% of nonpolar volatile isoparaffin;
the water phase comprises the following components in percentage by mass:
wherein the compound surfactant comprises alkyl glucoside and poloxamer.
2. The water-oil double-layer cleansing liquid according to claim 1, wherein the alkyl glucoside is a C12-C20 alkyl glucoside, preferably the alkyl glucoside includes at least one of octyl/decyl glucoside, coco glucoside, lauryl glucoside;
and/or the poloxamer comprises at least one of poloxamer 101, poloxamer 124, poloxamer 182, poloxamer 184, poloxamer 188, poloxamer 237, poloxamer 331, poloxamer 338 and poloxamer 407.
3. The water-oil double-layer makeup remover according to claim 1 or 2, characterized in that the mass percentage of the alkyl glucoside and the poloxamer is (14-50): 5, a step of;
the alkyl glucosides are based on the mass of octyl/decyl glucoside and the poloxamers are based on the mass of poloxamer 184.
4. The water-oil double-layer makeup remover according to claim 1 or 2, characterized in that the water-oil double-layer makeup remover comprises 28% -32% of an oil phase and 68% -72% of a water phase in mass percent;
the oil phase comprises the following components in percentage by mass:
23% -28% of synthetic polar grease;
35% -38% of light silicone oil;
35% -38% of nonpolar volatile isoparaffin;
the water phase comprises the following components in percentage by mass:
wherein the compound surfactant comprises alkyl glucoside and poloxamer.
5. The water-oil double-layer makeup remover according to claim 1 or 2, characterized in that the mass percentage of the alkyl glucoside and the poloxamer is (18-30): 5, a step of;
the alkyl glucosides are based on the mass of octyl/decyl glucoside and the poloxamers are based on the mass of poloxamer 184.
6. The water-oil double-layer makeup remover according to claim 1 or 2, wherein the synthetic polar oil comprises at least one of coco-caprylate/caprate, isopropyl palmitate, cetyl ethyl hexanoate, isononyl isononanoate;
and/or the light silicone oil comprises at least one of polydimethylsiloxane, octyl polydimethylsiloxane and cyclopentadimethylsiloxane;
and/or the non-polar volatile isoparaffin comprises at least one of isododecane and C13-15 alkane.
7. The water-oil double-layer makeup remover according to claim 1 or 2, wherein the soothing agent comprises at least one of allantoin, panthenol, purslane extract, centella asiatica extract;
and/or the cationic preservative comprises at least one of polyaminopropyl biguanide, cetrimide and benzethonium chloride;
and/or, the phosphate buffer pair comprises at least two of potassium phosphate, dipotassium hydrogen phosphate and potassium dihydrogen phosphate;
and/or, the water-soluble toner includes at least one of CI42090, CI17200, CI 19140;
and/or the thickener comprises at least one of sodium chloride, magnesium sulfate and potassium chloride;
and/or the compound surfactant is octyl/decyl glucoside and poloxamer 184.
8. The water-oil dual layer makeup remover according to claim 1 or 2, characterized in that the oil phase comprises coco-caprylate/caprate, polydimethylsiloxane and isododecane;
and/or the aqueous phase comprises allantoin, panthenol, polyurethane biguanide, octyl/decyl glucoside, poloxamer 184, CI42090, potassium phosphate, dipotassium hydrogen phosphate, sodium chloride, and water;
and/or the pH value of the water phase is 6.5-7.1.
9. The method for preparing the water-oil double-layer makeup remover according to any one of claims 1 to 8, comprising the following steps:
mixing materials containing synthetic polar oil, light silicone oil and nonpolar volatile isoparaffin to obtain an oil phase;
mixing materials II containing a thickening agent, water and a soothing agent to obtain a phase A;
adding a material containing a soothing agent, a cationic preservative, alkyl glucoside, poloxamer, water-soluble toner and phosphate buffer pair into the phase A for mixing III to obtain a water phase;
and filling the materials containing the oil phase and the water phase to obtain the water-oil double-layer cleansing liquid.
10. The method of claim 9, wherein the mixture I, the mixture II, the mixture III are independently selected from the following conditions:
the rotating speed is 250-350rpm;
the time is 3-7min;
and/or, the temperature of the mixture II is 75-85 ℃;
and/or the temperature of the mixture III is 20-45 ℃.
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