CN117481203A - Formula milk powder for children and preparation method thereof - Google Patents
Formula milk powder for children and preparation method thereof Download PDFInfo
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- CN117481203A CN117481203A CN202311627517.9A CN202311627517A CN117481203A CN 117481203 A CN117481203 A CN 117481203A CN 202311627517 A CN202311627517 A CN 202311627517A CN 117481203 A CN117481203 A CN 117481203A
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- formula
- milk powder
- children
- powder
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- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/16—Agglomerating or granulating milk powder; Making instant milk powder; Products obtained thereby
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/1522—Inorganic additives, e.g. minerals, trace elements; Chlorination or fluoridation of milk; Organic salts or complexes of metals other than natrium or kalium; Calcium enrichment of milk
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/1526—Amino acids; Peptides; Protein hydrolysates; Nucleic acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/1528—Fatty acids; Mono- or diglycerides; Petroleum jelly; Paraffine; Phospholipids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/158—Milk preparations; Milk powder or milk powder preparations containing additives containing vitamins or antibiotics
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Nutrition Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention provides children formula milk powder and a preparation method thereof. The children formula milk powder contains a protein composition which can improve the protein digestion performance in the children formula milk powder and is beneficial to the growth and development of children; wherein the protein composition comprises beta-casein and whey protein, and the mass ratio of the beta-casein to the whey protein is (0.8-1.3): 1. the children formula milk powder is easy to digest by children, and has positive effects in the aspects of immunoregulation, calcium absorption promotion and the like.
Description
Technical Field
The invention belongs to the technical field of children formula food, and particularly relates to children formula milk powder and a preparation method thereof, in particular to formula milk powder which is easy to digest and beneficial to growth and development of children and a preparation method thereof.
Background
Intake of sufficient quality dietary protein, such as that in milk, is critical to maintaining and promoting the growth and development of children (including weight, cognition, etc.) (Clark et al, 2020). While the nutritional value and efficacy of dietary proteins is largely dependent on the rate and extent of digestion in the gastrointestinal tract following their ingestion. Children and adults have little difference in most physiological digestive conditions such as pH, gastric motility, and digestive enzyme levels (Bourlieu et al, 2014), but children typically have less gastric volume, less gastric digestive fluid (Bourlieu et al, 2014; levi et al, 2017), which may result in a low protein digestibility (gastric emptying and enzymatic hydrolysis) during gastrointestinal tract digestion in children (Hodgkinson et al, 2018). While extensive research is currently being conducted on the digestion of food (i.e., milk) in adults and infants, little attention is paid to the digestion of children (Bourlieu et al, 2014).
Disclosure of Invention
In order to solve the technical problems, the invention aims to provide the children formula milk powder which can improve the protein digestion performance and the digestion products of the children formula milk powder are beneficial to the growth and development of children.
In order to achieve the above object, the present invention provides a children's formula, which contains a protein composition that can improve the digestion of proteins in children's formula and is beneficial to the growth and development of children; wherein the protein composition comprises beta-casein and whey protein, and the mass ratio of the beta-casein to the whey protein is (0.8-1.3): 1. in the mass ratio range, the children formula milk powder is easier for children to digest, has high gastric emptying rate and digestibility, and has positive effects in the aspects of immunoregulation, calcium absorption promotion and the like.
According to a specific embodiment of the present invention, preferably, the ratio of the β -casein to the whey protein is 0.8:1. 1:1, 1.2:1, or 1.3:1.
according to a specific embodiment of the present invention, preferably, the children's formula has a beta-casein content of 5.71-6.90g/100g and a whey protein content of 5.40-7.22g/100g, based on the mass of the children's formula.
According to a specific embodiment of the present invention, preferably, the children's formula has a beta-casein content of 5.71g/100g and a whey protein content of 7.22g/100g, based on the mass of the children's formula.
According to a specific embodiment of the present invention, preferably, the total protein content of the pediatric formula is 16.50-30g/100g, based on the mass of the pediatric formula; the fat content is 1-23g/100g; the content of dietary fiber is 0-9g/100g; the carbohydrate content is 30-69g/100g; more preferably, the dietary fiber comprises galactooligosaccharides.
According to a specific embodiment of the present invention, preferably, the source of the protein of the pediatric formula comprises one or more of raw milk, whey protein powder, desalted whey powder, skimmed milk powder, and a combination of two or more of said protein compositions; preferably, the raw materials of the children's formula milk powder based on 1000 parts by weight comprise: 0-4400 parts of raw milk, 25-500 parts of skimmed milk powder and 0-500 parts of desalted whey powder; more preferably, part or all of the milk, skim milk powder is replaced with a whole milk powder and/or skim milk of comparable protein content.
According to a specific embodiment of the present invention, preferably, the raw materials thereof include, based on 1000 parts by weight of the children's formula: 25-500 parts of skimmed milk powder and 0-500 parts of desalted whey powder.
According to a specific embodiment of the present invention, preferably, the source of fat of the pediatric formula comprises one or a combination of two or more of raw milk, whole milk powder, skim milk powder, desalted whey powder and phospholipids; preferably, the raw materials of the children's formula milk powder based on 1000 parts by weight comprise: 0-4400 parts of raw milk, 25-500 parts of skimmed milk powder, 0-500 parts of desalted whey powder and 1-5 parts of phospholipid; more preferably, the raw materials thereof include, based on 1000 parts by weight of the milk powder, 25 to 500 parts by weight of the skim milk powder, and 1 to 5 parts by weight of the phospholipid.
According to a specific embodiment of the present invention, preferably, the source of carbohydrates of the pediatric formula comprises a carbohydrate derived from a lactose-containing base stock and galactooligosaccharides; the lactose-containing basic raw material is one or the combination of more than two of raw milk, whole milk powder and skimmed milk powder; preferably, the raw materials of the children's formula milk powder based on 1000 parts by weight comprise: 30-250 parts of galacto-oligosaccharide.
According to a specific embodiment of the present invention, preferably, the raw materials of the children's formula comprise one or more than two of milk mineral salt, lactoferrin, DHA, ARA, zeaxanthin; preferably, the child formula milk powder comprises the following raw materials in parts by weight: 1-10 parts of milk mineral salt, 0-2 parts of lactoferrin, 0-10 parts of DHA, 0-10 parts of ARA and 0-0.1 part of zeaxanthin.
According to a specific embodiment of the present invention, preferably, the raw materials of the children's formula further comprise a compound nutrient of calcium powder, vitamins, minerals and choline chloride; more preferably, the raw materials of the children's formula milk powder based on 1000 parts by weight comprise: 7-22 parts by weight of compound nutrients comprising calcium powder, vitamins, minerals and choline chloride; more preferably, the compound nutrients are added at least in the form of a compound vitamin nutritional package, a calcium powder, a mineral nutritional package, and a choline chloride nutritional package; further preferably, the compound nutrient is added in the form of at least the following nutritional packages:
1) The compound vitamin nutrition package comprises the following components in each gram of compound vitamin nutrition package:
taurine: 145-175mg
Vitamin a:1800-2200 μg RE
Vitamin D:29-36 mug
Vitamin E:10.8-13.2mg alpha-TE
Vitamin K1:180-240 mug
Folic acid: 722-918 μg
Pantothenic acid: 8280-10120 mug
Nicotinamide: 10.8-13.2mg
Vitamin C:210-280mg
Lutein: 900-1090mg
2) The mineral one-nutrition package comprises the following components in each gram of mineral two-nutrition package:
iron: 85-104mg
Zinc: 70-90mg
3) The mineral secondary nutrition package comprises the following components in each gram of mineral primary nutrition package:
calcium: 368-434mg
4) The choline chloride nutrition packet comprises the following components in per gram:
choline chloride: 300-950mg;
preferably, based on 1000 parts by weight of the formula milk powder, the addition amount of the compound vitamin nutrition package is 1-4 parts by weight, the addition amount of the mineral one nutrition package is 0.5-3 parts by weight, the addition amount of the mineral two nutrition package is 2-16 parts by weight, the addition amount of choline chloride nutrition is 0.5-3 parts by weight, and the base material of each nutrition package is preferably lactose or L-sodium ascorbate.
The component contents of the compound nutrient are the content of nutrient components in other raw materials of the milk powder, for example, calcium powder (calcium carbonate) in a mineral two-nutrition package, and each 1000 kg of milk powder contains' calcium: 1300-1600g "means that to fortify the calcium element in the product, mineral di (e.g. calcium carbonate) nutritional packages are added based on 1000 kg weight of milk powder, wherein the weight of the calcium element is 1300-1600g.
According to a specific embodiment of the invention, wherein the raw materials of the children's formula comprise probiotics; preferably, the probiotic is bifidobacteria; more preferably, the raw materials of the children's formula milk powder based on 1000 parts by weight comprise: 0.4 parts by weight or less of bifidobacterium powder, more preferably 0.1 to 0.4 parts by weight, still more preferably 0.15 to 0.25 parts by weight; further preferably, per part by weight of the bifidobacteriumThe fungus powder contains 3×10 bifidobacteria 10 CFU or more.
According to a specific embodiment of the present invention, wherein the raw materials of the child formula comprise, based on 1000 parts by weight of the child formula:
7-22 parts by weight of compound nutrients comprising calcium powder, vitamins, minerals and choline chloride;
the specific dosage of each raw material in the formula milk powder provided by the invention is added and used on the premise of meeting the national standard and related standards and regulations of the prepared milk powder.
According to a specific embodiment of the invention, wherein the child formula is suitable for children over 3 years old. The children formula milk powder has better protein digestion, and the digestion products are more beneficial to the growth and development (immunity enhancement, amino acid supplementation and the like) of children, and can better promote the immunity/promote the calcium absorption by combining with the raw materials/nutrient supplementation of nutrients such as lactoferrin, vitamin D, calcium carbonate, choline chloride and the like.
On the other hand, the invention also provides a preparation method of the children formula milk powder, and the preparation process flow mainly comprises the following steps: proportioning, homogenizing, concentrating, sterilizing, spray drying and dry mixing to obtain the finished product. The preparation method comprises the following steps:
(1) Mixing pasteurized milk, powder raw materials, galactooligosaccharide and melted grease raw materials, and adding compound nutrients to obtain mixed feed liquid;
(2) Filtering, homogenizing, cooling, concentrating, sterilizing, spray drying, fluidized bed drying, cooling to obtain dried milk powder, mixing with DHA, ARA, lactoferrin, and Bacillus bifidus, and sieving to obtain the children formula milk powder.
In the above preparation method, preferably, the step (1) is performed in the following manner: sucking the raw materials of the pasteurized milk and the powder preparation tank into a vacuum mixing tank, adding galactooligosaccharide and dissolved oil raw materials (such as phospholipid) into a small hopper, pumping into the vacuum mixing tank, and adding the compound nutrition enhancer into a nutrient tank to prepare mixed feed liquid.
In the above preparation method, preferably, the primary pressure of the homogenization treatment of the mixed liquor is 105±5bar, and the secondary pressure is 32±3bar.
In the preparation method, preferably, the concentration sterilization adopts double-effect concentration, more preferably, the sterilization temperature is more than or equal to 83 ℃, and the sterilization time is 25 seconds; further preferably, the discharge concentrations are all 48% -52% dry matter.
In the above preparation method, preferably, the spray drying has an inlet air temperature of 165-180deg.C, an outlet air temperature of 75-90deg.C, a high pressure pump pressure of 160-210bar, and a column negative pressure of-4 mbar to-2 mbar.
In the above preparation method, preferably, the fluidized bed drying and cooling comprises two times of drying and cooling, and the temperature of the milk powder after the two times of drying and cooling is 25-30 ℃; and mixing phospholipid with carrier, heating to 60-65deg.C, and dispersing on the surface of milk powder under the action of compressed air.
The technical scheme of the invention has the following beneficial effects:
compared with common milk and common milk powder (the mass ratio of beta-casein/whey protein is 1.5-1.6:1), the children formula milk powder is easier to digest, and digestion products have positive influence on the growth and development of children in terms of amino acid generation, and the children formula milk powder can be more beneficial to the growth and development of children by combining with other nutrients such as calcium, DHA, galacto-oligosaccharide, zinc, iron, vitamin A, vitamin D, vitamin E and dietary fiber.
Drawings
FIG. 1 shows the results of statistics of protein digestibility after gastrointestinal digestion for 120min for the samples of examples 2 and 4 and comparative examples 1 and 2;
FIG. 2 shows the results of analysis of the gastric residues obtained by digesting the samples of examples 2 and 4 and comparative examples 1 and 2 for 120 min.
Detailed Description
The following detailed description of the method for preparing the children's formula of the present invention is provided by way of specific examples, which are intended to assist the reader in better understanding the nature and characteristics of the present invention, and are not intended to limit the scope of the invention. The procedure not specifically identified in the examples below is generally followed by conventional procedures in the art.
According to a specific embodiment of the present invention, preferably, the process for preparing the children's formula of the present invention may comprise the following specific steps:
1) Coarse filtration of milk: after coarse filtration and degassing of the balance cylinder, the milk is preheated by a plate heat exchanger and then separated from impurities by a separator.
2) Homogenizing and sterilizing milk: part of the milk after removing the impurities enters a homogenizer for homogenization, the other part of the milk is not homogenized, the homogenized milk and the non-homogenized milk are mixed and then enter a sterilizing system for sterilization, and the sterilized milk enters a mixing tank.
3) Powder adding: the various powder raw materials are metered according to the formula and then are uniformly added into a powder preparation tank for storage through an air-assisted system.
4) Vacuum powder suction: various powder raw materials in the powder preparation tank are sucked into the mixing tank through a vacuum system.
5) And (3) dissolving and adding a compound nutrition enhancer: the compound vitamin nutrition package, the mineral first nutrition package, the mineral second nutrition package and the choline chloride nutrition package are respectively added, dissolved by 100-200kg purified water respectively, and then are added into a mixing tank, and the adding tank and the pipeline are flushed by 100kg purified water after each time.
6) And (3) adding small materials: galacto-oligosaccharide paddles, and a melted fat material (e.g., phospholipids) are added to a small hopper and pumped into a mixing tank.
7) And (3) filtering: and mixing all the raw materials in a mixing tank, and filtering the mixed feed liquid by a filter screen to remove physical impurities possibly carried in the raw materials.
8) Homogenizing: homogenizing the mixed feed liquid by a homogenizer, wherein the primary pressure is 105+/-5 bar, the secondary pressure is 32+/-3 bar, and mechanically treating the fat globules to disperse the fat globules into uniform fat globules.
9) Cooling and storing: the homogenized feed liquid enters a plate heat exchanger for cooling, the temperature is lower than 20 ℃, the homogenized feed liquid is temporarily stored in a pre-storing cylinder, the next working procedure is carried out within 6 hours, and a stirrer is started according to set requirements.
10 Concentration sterilization: during production, double-effect concentration is used, the sterilization temperature is more than or equal to 83 ℃, and the sterilization time is 25 seconds; the discharge concentration is 48% -52% of dry matter.
11 Concentrated milk storage, pre-heating filtration, spray drying: temporarily storing the concentrated milk in a concentrated milk balance tank; preheating to 60-70deg.C by scraper preheater, filtering the preheated material by 1mm pore diameter filter, spraying with high pressure pump, drying, and agglomerating fine powder on top of tower or fluidized bed; wherein the air inlet temperature is 165-180 ℃, the air outlet temperature is 75-90 ℃, the high-pressure pump pressure is 160-210bar, and the negative pressure of the tower is-4 mbar to-2 mbar.
12 Fluidized bed drying and cooling: the milk powder from the drying tower is subjected to secondary drying by a fluidized bed (first stage) and then is cooled to 25-30 ℃ by the fluidized bed (second stage); and meanwhile, the phospholipid and the carrier are mixed and then heated to 60-65 ℃, and the phospholipid is uniformly dispersed on the surface of the milk powder under the action of compressed air, so that the granularity and the quick solubility of the powder particles are increased by agglomerating the powder particles.
13 Split charging: weighing DHA, ARA, lactoferrin and bifidobacterium according to the formula requirement, sealing bags and subpackaging.
14 Dry blending): and uniformly mixing the weighed DHA, ARA, lactoferrin, bifidobacterium and milk powder base powder in a dry mixer.
15 Screening powder: the granularity of the milk powder is uniform through the vibrating screen, and the powder slag is scrapped.
16 Powder discharge: and (3) receiving powder by using a sterilized powder collecting box, and conveying the powder from a powder outlet room to a powder feeding room.
17 Powder) is added: and pouring the milk powder into a powder storage tank on a size packaging machine according to the packaging requirement.
18 Packaging: nitrogen filling and packaging of automatic packaging machines with different specifications; the oxygen content is lower than 1-5% when nitrogen is filled.
29 Boxing: packaging the packaged small bags into a paper box, adding a powder spoon at the same time, and sealing by a box sealing machine.
20 Inspection of the finished product: sampling and checking the packaged product according to a checking plan.
21 Warehousing and storing: the qualified products are stored in warehouse, and the storage is required at normal temperature, and the humidity is less than or equal to 65%.
Example 1
The embodiment provides a children's formula milk powder which is easy to digest and beneficial to children's growth and development, wherein the protein content of the formula milk powder is 22.1g/100g, the fat content of the formula milk powder is 16.1g/100g, the carbohydrate content of the formula milk powder is 48.1g/100g, the beta-casein content of the formula milk powder is 6.9g/100g, the whey protein content of the formula milk powder is 5.4g/100g, and the mass ratio of the beta-casein to the whey protein is 1.3:1. wherein the protein source is raw milk, skimmed milk powder and desalted whey powder.
The formula comprises the following raw materials in parts by weight: raw milk 4400 parts, desalted whey powder 80 parts, skimmed milk powder 295 parts, galacto-oligosaccharides 90 parts, milk mineral salt 5 parts, phospholipid 2 parts, mineral two nutrient packages 16 parts, compound vitamin nutrient packages 2.5 parts, mineral one nutrient package 1 part, zeaxanthin 0.05 parts, DHA5.5 parts, ARA 6 parts, lactoferrin 0.45 parts and bifidobacterium (powder) 0.2 parts.
The preparation process of this example is described above.
Example 2
The embodiment provides a children's formula milk powder which is easy to digest and beneficial to children's growth and development, wherein the protein content of the formula milk powder is 22.3g/100g, the fat content of the formula milk powder is 14.8g/100g, the carbohydrate content of the formula milk powder is 49.4g/100g, the beta-casein content of the formula milk powder is 6.61g/100g, the whey protein content of the formula milk powder is 5.64g/100g, and the mass ratio of the beta-casein to the whey protein is 1.2:1. wherein the protein source is raw milk, skimmed milk powder and desalted whey powder.
The formula comprises the following raw materials in parts by weight: 4000 parts of raw milk, 115 parts of desalted whey powder, 300 parts of skimmed milk powder, 100 parts of galacto-oligosaccharide, 5 parts of milk mineral salt, 2 parts of phospholipid, 16 parts of mineral two-nutrient package, 2.5 parts of compound vitamin nutrition package, 1 part of mineral one-nutrient package, 0.05 part of zeaxanthin, 5.5 parts of DHA, 6 parts of ARA, 0.45 part of lactoferrin and 0.2 part of bifidobacterium (powder).
The preparation process of this example is the same as that of example 1.
Example 3
The embodiment provides a children formula milk powder which is easy to digest and beneficial to children to grow and develop, wherein the protein content of the formula milk powder is 22.4g/100g, the fat content of the formula milk powder is 8.5g/100g, the carbohydrate content of the formula milk powder is 55.6g/100g, the beta-casein content of the formula milk powder is 6.35g/100g, the whey protein content of the formula milk powder is 6.5g/100g, and the mass ratio of the beta-casein to the whey protein is 1:1. wherein the protein source is raw milk, skimmed milk powder and desalted whey powder.
The formula comprises the following raw materials in parts by weight: 2100 parts of raw milk, 200 parts of desalted whey powder, 445 parts of skimmed milk powder, 100 parts of galacto-oligosaccharide, 5 parts of milk mineral salt, 2 parts of phospholipid, 16 parts of mineral two-nutrient package, 2.5 parts of compound vitamin nutrition package, 1 part of mineral one-nutrient package, 0.05 part of zeaxanthin, 5.5 parts of DHA, 6 parts of ARA, 0.45 part of lactoferrin and 0.2 part of bifidobacterium (powder).
The preparation process of this example is the same as that of example 1.
Example 4
The embodiment provides a children's formula milk powder which is easy to digest and beneficial to children's growth and development, wherein the protein content of the formula milk powder is 19.7g/100g, the fat content of the formula milk powder is 14.1g/100g, the carbohydrate content of the formula milk powder is 53.2g/100g, the beta-casein content of the formula milk powder is 5.71g/100g, the whey protein content of the formula milk powder is 7.22g/100g, and the mass ratio of the beta-casein to the whey protein is 0.8:1. wherein the protein source is raw milk, skimmed milk powder and desalted whey powder.
The formula comprises the following raw materials in parts by weight: raw milk 3800 parts, desalted whey powder 275 parts, skimmed milk powder 175 parts, galacto-oligosaccharide 90 parts, milk mineral salt 5 parts, phospholipid 2 parts, mineral two nutrient package 16 parts, compound vitamin nutrient package 2.5 parts, mineral one nutrient package 1 part, zeaxanthin 0.05 parts, DHA5.5 parts, ARA 6 parts, lactoferrin 0.45 parts and bifidobacterium (powder) 0.2 parts.
The preparation process of this example is the same as that of example 1.
Comparative example 1
The formula provided in the comparative example 1 has a protein content of 26.3g/100g, a fat content of 13.9g/100g, a carbohydrate content of 49.9g/100g, a beta-casein content of 8.41g/100g, a whey protein content of 5.4g/100g, and a mass ratio of beta-casein to whey protein of 1.6:1. wherein the protein source is raw milk and skimmed milk powder.
The formula comprises the following raw materials in parts by weight: the milk powder comprises, by weight, 3800 parts of raw milk 3800 parts of skim milk powder 500 parts of galacto-oligosaccharide 30 parts, 5 parts of milk mineral salts, 2 parts of phospholipids, 16 parts of mineral di-nutrient packages, 2.5 parts of compound vitamin nutrient packages, 1 part of mineral-nutrient packages, 0.05 part of zeaxanthin, 5.5 parts of DHA, 6 parts of ARA, 0.45 parts of lactoferrin and 0.2 part of bifidobacterium (powder).
The preparation process of this example is the same as that of example 1.
Comparative example 2
The comparative example 2 is raw milk, the protein content is 2.9g/100g, the fat content is 3.5g/100g, the beta-casein content is 0.89g/100g, the whey protein content is 0.6g/100g, and the proportion of beta-casein to whey protein is 1.5:1.
the invention uses a dynamic gastrointestinal system for simulating digestion of children in vitro to test the 4 examples and 2 comparative examples, so as to verify the digestion condition of samples with different beta-casein/whey protein mass ratios in the digestion system of children, and further verify the positive effect of digestion products on normal growth and development of children through analysis of free amino acids after digestion of the samples.
As shown in table 1, the main difference between example 1 and example 2 is that the mass ratio of β -casein/whey protein was adjusted.
The main difference between example 2 and example 3 is that the beta-casein/whey protein mass ratio is further adjusted.
The main difference between example 3 and example 4 is that the beta-casein/whey protein mass ratio is further adjusted.
Comparative example 1 is a conventional milk powder having a beta-casein/whey protein mass ratio of 1.6:1, a step of; comparative example 2 is raw milk.
Table 1 statistics of protein content in samples
1 test protocol
1.2 sample preparation
Corresponding samples were prepared as in examples 2 and 4 and comparative examples 1 and 2 above.
1.3 Experimental methods
1.3.1 determination of digestion product pH and gastric emptying Rate
The pH of the gastric and intestinal sample digests collected at 60min and 120min was measured using a pH meter. The gastric emptying rate of the sample is represented by the mass retention with respect to digestion time. The gastric emptying rate (%) at 60min was calculated as the percentage of the total mass of raw material introduced into the gastric model during 60min based on the amount of sample digest remaining in the gastric model. The same method was used to calculate the gastric emptying rate at 120 min.
1.3.2 determination of protein digestibility
The protein concentration of the gastric and intestinal sample digests collected at 60min and 120min was determined by the micro-kjeldahl method. The in vitro protein digestibility (%) of the sample was calculated as the percentage of hydrolyzed protein to the initial protein content in the sample.
1.3.3 statistical analysis
All experiments were performed in at least duplicate to ensure good reproducibility, and the results are expressed as mean ± standard deviation. Statistical differences in vitro gastric emptying rate, protein digestibility, and free amino acids after digestion of samples were verified by one-way analysis of variance (ANOVA) and Tukey multiple comparison t-test. p <0.05, indicating statistical differences.
2 experimental results
2.1 intragastric pH Change
The pH change trend in the stomach of the four samples is similar, the pH is rapidly reduced within 0-30min, and the pH is reduced to about 2-3 within 120 min; the sample of comparative example 2 was slightly higher than the other three samples within 0-15min, and rapidly decreased within 15-30min, slightly lower than the other samples.
2.2 gastric emptying rate
The samples of examples 2 and 4 were slightly more gastric-empty than the samples of comparative examples 1 and 2; gastric half-emptying time (t 1/2) for four samples: comparative example 1> comparative example 2> example 4> example 2, but there was no significant difference between the samples.
2.3 Kjeldahl method for measuring protein digestibility
Four samples simulated protein digestibility of 120min by gastric digestion alone, as shown in fig. 1, with the lowest protein digestibility for the comparative example 2 (4 #) sample, and no significant differences for the other three. During gastric digestion, the samples of comparative example 1 (1 #), example 2 (2 #), example 4 (3 #), example 2, and example 4 were slightly more digested, followed by the samples of example 4 and comparative example 1. Casein precipitates in the stomach when exposed to acid, which may be responsible for slightly lower digestibility of the sample of comparative example 1; however, the beta-Lg and alpha-La in whey protein have some gastric digestion resistance, which may be responsible for slightly lower protein digestibility in the sample of example 4.
2.4 apparent, microstructural analysis of digestion products
As shown in fig. 2, the caking of the samples of comparative example 1 (1 #) and comparative example 2 (4 #) was most pronounced, which may be responsible for slightly slower emptying of comparative example 1, comparative example 2. In contrast, the samples of example 2 (2 #) and example 4 (3 #) had less caking after digestion and example 2 was almost invisible to the naked eye.
2.5 comparison of protein, polypeptide and amino acid content after digestion of samples
As shown in table 2, the mass ratio of β -casein/whey protein = 0.8:1 (example 4), the higher the ratio of absorbable amino acid content and total protein, polypeptide and amino acid content of the sample after digestion, corresponding to the higher degree of proteolysis of the ratio during the digestion phase, suggests that the β -casein/whey protein ratio = 0.8:1 is more absorbable.
TABLE 2 comparison of protein, polypeptide and amino acid content after digestion of samples
2.6 comparison of free amino acids before and after digestion of different samples
Further, the analytical data of the free amino acids before and after digestion of the samples of different beta-casein/whey protein ratios are shown in tables 3 and 4, and the free amino acids before and after digestion of the samples of different beta-casein/whey protein ratios were found by analyzing:
the sample before digestion had the highest glutamic acid (Glu) content and the highest tyrosine (Tyr) content after digestion. Compared with the prior digestion, the content of all amino acids in the digested sample is improved to different degrees, wherein the contents of tyrosine, arginine, lysine, phenylalanine and the like are obviously increased.
The majority of amino acid content in the post-digestion samples were significantly different, with higher levels of arginine, cysteine, histidine, leucine/isoleucine, lysine, phenylalanine, serine, threonine, tryptophan, tyrosine, valine corresponding to the post-digestion-example 4 samples; the post digestion-comparative example 2 samples were higher in alanine, asparagine, glutamine, histidine, leucine/isoleucine, methionine, serine, tryptophan, proline; the post-digestion-comparative example 1 sample had a higher content of glutamic acid and glycine.
Total amino acid (T): 92.447-96.076 mg/L before digestion, 9076.492-10116.462 mg/L after digestion, and about 100 times of total free amino acids before digestion.
Essential amino acid (E): 9.164-13.976 mg/L before digestion and 3828.845-4316.135 mg/L after digestion are the highest samples of example 4.
Non-essential amino acid (N): 78.471-85.969 mg/L before digestion and 5247.647-5800.327 mg/L after digestion.
Essential amino acids (CE) for children: 1.797-2.116 mg/L before digestion and 816.955-957.397 mg/L after digestion are the highest samples of example 4.
Ratio of essential amino acids to total amino acid content (E/T): the ratio was gradually increased from 0.096 to 0.151 before digestion, from 0.419 to 0.427 after digestion, comparative example 1, examples 2 to 4.
Ratio of essential amino acids to non-essential amino acids (E/N): the ratio of 0.107 to 0.178 before digestion, 0.721 to 0.745 after digestion, comparative example 1, examples 2 to 4, gradually increases.
Ratio of essential amino acids to total amino acid content (CE/T) for children: essential amino acids for children include histidine and arginine, which play a vital role in the growth and development process of children, and lysine (for children with short height, the effect of promoting physical development can be achieved by supplementing a certain amount of lysine) is 0.019-0.023 before digestion, and 0.090-0.095 after digestion, which is the highest sample of the example 4.
Thus, example 4 is more useful for the supplementation of essential amino acids in children, as analyzed from the point of view of essential amino acid supplementation in children.
TABLE 3 analysis of free amino acids before digestion of samples of different beta-Casein/whey protein ratios (units: mg/L)
TABLE 4 analysis of free amino acids after digestion of samples with different beta-Casein/whey protein ratios (units: mg/L)
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Remarks: dilution correction was performed on the digested samples.
Remarks: amino acid content is expressed as mean ± standard deviation, the difference between the same letter in the same row is not significant (p > 0.05), and the difference between the different letters in the same row is significant (p < 0.05). "#" is an essential amino acid and "#" is an essential amino acid for children. Essential amino acids are denoted by E; the nonessential amino acids are denoted by N; essential amino acids for children are represented by CE; the total amino acids are represented by T; the ratio of essential amino acids to non-essential amino acids is expressed as E/N; the ratio of essential amino acids to total amino acids is expressed as E/T; the ratio of essential amino acids to total amino acids in children is expressed as CE/T.
Summary of 3 analysis
The example 2 sample and the example 4 sample showed a better trend in terms of the gastric emptying rate and the protein digestion rate; meanwhile, the caking was most evident from the appearance of the digested products, the sample of comparative example 1 and the sample of comparative example 2, and the sample of example 4 was almost free of caking. This reflects that the beta-casein/whey protein mass ratio is between (0.8-1.3): between 1, it is easier for children to digest. Further, the sample of example 4 had the highest levels of amino acids necessary for digestion, amino acids necessary for children (histidine, arginine, lysine) and total amino acids.
In combination, the mass ratio of beta-casein/whey protein is between (0.8-1.3) compared to ordinary milk and ordinary milk powder (the mass ratio of beta-casein/whey protein is between 1.5-1.6:1): the children formula milk powder between 1 is easier to digest, and the digestive products have positive influence on the growth and development of children in terms of amino acid generation, and can be more beneficial to the growth and development of children by combining with other nutrients (calcium, DHA, galacto-oligosaccharides, zinc, iron, vitamin A, vitamin D, vitamin E and dietary fibers).
Claims (10)
1. A children's formula, which contains a protein composition that can improve the digestion of proteins in children's formula and facilitate the growth and development of children; wherein the protein composition comprises beta-casein and whey protein, and the mass ratio of the beta-casein to the whey protein is (0.8-1.3): 1.
2. the pediatric formula of claim 1, wherein the pediatric formula has a beta-casein content of 5.71-6.90g/100g and a whey protein content of 5.40-7.22g/100g, based on the mass of the pediatric formula.
3. The children's formula according to claim 1 or 2, wherein the children's formula has a total protein content of 16.50-30g/100g, based on the mass of the children's formula;
the fat content is 1-23g/100g;
the dietary fiber content is 0-9g/100g, preferably, the dietary fiber comprises galacto-oligosaccharides;
the carbohydrate content is 30-69g/100g.
4. A pediatric formula according to claim 3 wherein the source of protein of the pediatric formula comprises one or a combination of two or more of raw milk, whey protein powder, desalted whey powder, skimmed milk powder, and the protein composition;
preferably, the raw materials of the children's formula milk powder based on 1000 parts by weight comprise: 0-4400 parts of raw milk, 25-500 parts of skimmed milk powder and 0-500 parts of desalted whey powder;
more preferably, part or all of the milk, skim milk powder is replaced with a whole milk powder and/or skim milk of comparable protein content.
5. A pediatric formula according to claim 3 wherein the source of fat of the pediatric formula comprises one or a combination of two or more of raw milk, whole milk powder, skim milk powder, desalted whey powder and phospholipids;
preferably, the raw materials of the children's formula milk powder based on 1000 parts by weight comprise: 0-4400 parts of raw milk, 25-500 parts of skimmed milk powder, 0-500 parts of desalted whey powder and 1-5 parts of phospholipid;
more preferably, the raw materials thereof include, based on 1000 parts by weight of the milk powder, 25 to 500 parts by weight of the skim milk powder, and 1 to 5 parts by weight of the phospholipid.
6. A pediatric formula according to claim 3 wherein the source of carbohydrates for the pediatric formula comprises milk from a lactose-containing base stock and galactooligosaccharides;
the lactose-containing basic raw material is one or the combination of more than two of raw milk, whole milk powder and skimmed milk powder;
preferably, the raw materials of the children's formula milk powder based on 1000 parts by weight comprise: 30-250 parts by weight of galacto-oligosaccharide;
the raw materials of the children formula milk powder comprise one or more than two of milk mineral salt, lactoferrin, DHA, ARA and zeaxanthin;
preferably, the child formula milk powder comprises the following raw materials in parts by weight: 1-10 parts of milk mineral salt, 0-2 parts of lactoferrin, 0-10 parts of DHA, 0-10 parts of ARA and 0-0.1 part of zeaxanthin;
the raw materials of the children formula milk powder also comprise calcium powder, vitamins, minerals and choline chloride compound nutrients;
preferably, the raw materials of the children's formula milk powder based on 1000 parts by weight comprise: 7-22 parts by weight of compound nutrients comprising calcium powder, vitamins, minerals and choline chloride;
more preferably, the compound nutrients are added at least in the form of a compound vitamin nutritional package, a calcium powder, a mineral nutritional package, and a choline chloride nutritional package; further preferably, the compound nutrient is added in the form of at least the following nutritional packages:
1) The compound vitamin nutrition package comprises the following components in each gram of compound vitamin nutrition package:
taurine: 145-175mg
Vitamin a:1800-2200 μg RE
Vitamin D:29-36 mug
Vitamin E:10.8-13.2mg alpha-TE
Vitamin K1:180-240 mug
Folic acid: 722-918 μg
Pantothenic acid: 8280-10120 mug
Nicotinamide: 10.8-13.2mg
Vitamin C:210-280mg
Lutein: 900-1090mg
2) The mineral one-nutrition package comprises the following components in each gram of mineral two-nutrition package:
iron: 85-104mg
Zinc: 70-90mg
3) The mineral secondary nutrition package comprises the following components in each gram of mineral primary nutrition package:
calcium: 368-434mg
4) The choline chloride nutrition packet comprises the following components in per gram:
choline chloride: 300-950mg;
preferably, based on 1000 weight parts of formula milk powder, the addition amount of the compound vitamin nutrition package is 1 to 4 weight parts, the addition amount of the mineral one nutrition package is 0.5 to 3 weight parts, the addition amount of the mineral two nutrition package is 2 to 16 weight parts, and the addition amount of the choline chloride nutrition is0.5-3The base material of each nutrition package is preferably lactose or L-sodium ascorbate in parts by weight.
7. A child formula according to claim 3, wherein the raw materials of the child formula comprise probiotics;
preferably, the probiotic is bifidobacteria;
more preferably, the raw materials of the children's formula milk powder based on 1000 parts by weight comprise: 0.4 parts by weight or less of bifidobacterium powder, more preferably 0.1 to 0.4 parts by weight, still more preferably 0.15 to 0.25 parts by weight;
further preferably, the content of bifidobacteria per part by weight of the bifidobacteria powder is 3X 10 10 CFU or more.
8. The pediatric formula according to any one of claims 1 to 7, wherein the raw materials of the pediatric formula comprise, based on 1000 parts by weight of the pediatric formula:
7-22 parts by weight of compound nutrients comprising calcium powder, vitamins, minerals and choline chloride;
9. the pediatric formula of any of claims 1-8, wherein the pediatric formula is suitable for children over 3 years of age.
10. A method of preparing a children's formula according to any one of claims 1-9, comprising the steps of:
mixing pasteurized milk, powder raw materials, galactooligosaccharide and melted grease raw materials, and adding compound nutrients to obtain mixed feed liquid;
filtering, homogenizing, cooling, concentrating, sterilizing, spray drying, fluidized bed drying, cooling to obtain dried milk powder, mixing with DHA, ARA, lactoferrin, nucleotide and bifidobacterium, and sieving to obtain the children formula milk powder;
preferably, the primary pressure of the homogenization treatment of the mixed liquor is 105+/-5 bar, and the secondary pressure is 32+/-3 bar;
preferably, the concentration sterilization adopts double-effect concentration, more preferably, the sterilization temperature is more than or equal to 83 ℃, and the sterilization time is 25 seconds; further preferably, the discharge concentrations are all 48% -52% dry matter;
preferably, the inlet air temperature of the spray drying is 165-180 ℃, the exhaust air temperature is 75-90 ℃, the pressure of the high-pressure pump is 160-210bar, and the negative pressure of the tower is-4 mbar to-2 mbar;
preferably, the fluidized bed drying and cooling comprises two times of drying and cooling, and the temperature of the milk powder after the two times of drying and cooling is 25-30 ℃; and mixing phospholipid with carrier, heating to 60-65deg.C, and dispersing on the surface of milk powder under the action of compressed air.
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