CN117466744A - 一种光化学铁催化合成芳胺类化合物的方法 - Google Patents
一种光化学铁催化合成芳胺类化合物的方法 Download PDFInfo
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- CN117466744A CN117466744A CN202311448033.8A CN202311448033A CN117466744A CN 117466744 A CN117466744 A CN 117466744A CN 202311448033 A CN202311448033 A CN 202311448033A CN 117466744 A CN117466744 A CN 117466744A
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- iron
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- aromatic amine
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- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 title claims abstract description 62
- -1 arylamine compound Chemical class 0.000 title claims abstract description 36
- 229910052742 iron Inorganic materials 0.000 title claims abstract description 30
- 238000000034 method Methods 0.000 title claims abstract description 28
- 238000006555 catalytic reaction Methods 0.000 title claims abstract description 14
- 230000002194 synthesizing effect Effects 0.000 title claims abstract description 14
- 238000006243 chemical reaction Methods 0.000 claims abstract description 19
- 239000003054 catalyst Substances 0.000 claims abstract description 18
- 150000001499 aryl bromides Chemical class 0.000 claims abstract description 15
- ROFVEXUMMXZLPA-UHFFFAOYSA-N Bipyridyl Chemical compound N1=CC=CC=C1C1=CC=CC=N1 ROFVEXUMMXZLPA-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000012300 argon atmosphere Substances 0.000 claims abstract description 5
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 13
- OEBXWWBYZJNKRK-UHFFFAOYSA-N 1-methyl-2,3,4,6,7,8-hexahydropyrimido[1,2-a]pyrimidine Chemical compound C1CCN=C2N(C)CCCN21 OEBXWWBYZJNKRK-UHFFFAOYSA-N 0.000 claims description 8
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 6
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 5
- 150000007530 organic bases Chemical class 0.000 claims description 5
- KYVBNYUBXIEUFW-UHFFFAOYSA-N 1,1,3,3-tetramethylguanidine Chemical compound CN(C)C(=N)N(C)C KYVBNYUBXIEUFW-UHFFFAOYSA-N 0.000 claims description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 4
- 150000001408 amides Chemical class 0.000 claims description 4
- 150000004982 aromatic amines Chemical class 0.000 claims description 4
- 125000003118 aryl group Chemical group 0.000 claims description 4
- 239000003960 organic solvent Substances 0.000 claims description 4
- 239000004277 Ferrous carbonate Substances 0.000 claims description 3
- RAQDACVRFCEPDA-UHFFFAOYSA-L ferrous carbonate Chemical compound [Fe+2].[O-]C([O-])=O RAQDACVRFCEPDA-UHFFFAOYSA-L 0.000 claims description 3
- 229960004652 ferrous carbonate Drugs 0.000 claims description 3
- 235000019268 ferrous carbonate Nutrition 0.000 claims description 3
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims description 3
- 238000005286 illumination Methods 0.000 claims description 3
- 229910000015 iron(II) carbonate Inorganic materials 0.000 claims description 3
- 125000003386 piperidinyl group Chemical group 0.000 claims description 3
- ZFDWWDZLRKHULH-UHFFFAOYSA-N 1,2-dimethyl-5,6-dihydro-4h-pyrimidine Chemical compound CN1CCCN=C1C ZFDWWDZLRKHULH-UHFFFAOYSA-N 0.000 claims description 2
- VSTXCZGEEVFJES-UHFFFAOYSA-N 1-cycloundecyl-1,5-diazacycloundec-5-ene Chemical compound C1CCCCCC(CCCC1)N1CCCCCC=NCCC1 VSTXCZGEEVFJES-UHFFFAOYSA-N 0.000 claims description 2
- 229910021575 Iron(II) bromide Inorganic materials 0.000 claims description 2
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 claims description 2
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims description 2
- MCDLETWIOVSGJT-UHFFFAOYSA-N acetic acid;iron Chemical compound [Fe].CC(O)=O.CC(O)=O MCDLETWIOVSGJT-UHFFFAOYSA-N 0.000 claims description 2
- 125000000641 acridinyl group Chemical group C1(=CC=CC2=NC3=CC=CC=C3C=C12)* 0.000 claims description 2
- 125000002252 acyl group Chemical group 0.000 claims description 2
- 125000003545 alkoxy group Chemical group 0.000 claims description 2
- 125000006615 aromatic heterocyclic group Chemical class 0.000 claims description 2
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims description 2
- 229910052796 boron Inorganic materials 0.000 claims description 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 2
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 claims description 2
- 150000002148 esters Chemical class 0.000 claims description 2
- 229940046149 ferrous bromide Drugs 0.000 claims description 2
- 229960002089 ferrous chloride Drugs 0.000 claims description 2
- 229910052736 halogen Inorganic materials 0.000 claims description 2
- 150000002367 halogens Chemical class 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 claims description 2
- NMCUIPGRVMDVDB-UHFFFAOYSA-L iron dichloride Chemical compound Cl[Fe]Cl NMCUIPGRVMDVDB-UHFFFAOYSA-L 0.000 claims description 2
- GYCHYNMREWYSKH-UHFFFAOYSA-L iron(ii) bromide Chemical compound [Fe+2].[Br-].[Br-] GYCHYNMREWYSKH-UHFFFAOYSA-L 0.000 claims description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 2
- 125000003373 pyrazinyl group Chemical group 0.000 claims description 2
- 125000003226 pyrazolyl group Chemical group 0.000 claims description 2
- 125000004076 pyridyl group Chemical group 0.000 claims description 2
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims description 2
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 claims description 2
- 125000001424 substituent group Chemical group 0.000 claims description 2
- 125000003107 substituted aryl group Chemical group 0.000 claims description 2
- 229940124530 sulfonamide Drugs 0.000 claims description 2
- 150000003456 sulfonamides Chemical class 0.000 claims description 2
- 125000000335 thiazolyl group Chemical group 0.000 claims description 2
- 125000001544 thienyl group Chemical group 0.000 claims description 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims description 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 2
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 2
- 125000005509 dibenzothiophenyl group Chemical group 0.000 claims 1
- 125000005936 piperidyl group Chemical group 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 abstract description 21
- 238000003786 synthesis reaction Methods 0.000 abstract description 7
- 239000003446 ligand Substances 0.000 abstract description 6
- 230000015572 biosynthetic process Effects 0.000 abstract description 5
- 230000003197 catalytic effect Effects 0.000 abstract description 4
- 230000008901 benefit Effects 0.000 abstract description 3
- 125000000524 functional group Chemical group 0.000 abstract description 3
- 229910052751 metal Inorganic materials 0.000 abstract description 3
- 239000002184 metal Substances 0.000 abstract description 3
- 150000003839 salts Chemical class 0.000 abstract description 3
- 150000007529 inorganic bases Chemical class 0.000 abstract description 2
- 238000007146 photocatalysis Methods 0.000 abstract description 2
- 230000001699 photocatalysis Effects 0.000 abstract description 2
- 239000003513 alkali Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
- QARVLSVVCXYDNA-UHFFFAOYSA-N bromobenzene Chemical compound BrC1=CC=CC=C1 QARVLSVVCXYDNA-UHFFFAOYSA-N 0.000 description 56
- 239000000047 product Substances 0.000 description 31
- 238000001228 spectrum Methods 0.000 description 28
- HQABUPZFAYXKJW-UHFFFAOYSA-N butan-1-amine Chemical compound CCCCN HQABUPZFAYXKJW-UHFFFAOYSA-N 0.000 description 17
- XLQSXGGDTHANLN-UHFFFAOYSA-N 1-bromo-4-(trifluoromethyl)benzene Chemical compound FC(F)(F)C1=CC=C(Br)C=C1 XLQSXGGDTHANLN-UHFFFAOYSA-N 0.000 description 16
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- 230000008569 process Effects 0.000 description 5
- 238000001308 synthesis method Methods 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 4
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 4
- 230000008878 coupling Effects 0.000 description 4
- 238000010168 coupling process Methods 0.000 description 4
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 3
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 3
- 150000001502 aryl halides Chemical class 0.000 description 3
- 229910052802 copper Inorganic materials 0.000 description 3
- 239000010949 copper Substances 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 239000012043 crude product Substances 0.000 description 2
- 150000004698 iron complex Chemical class 0.000 description 2
- 159000000014 iron salts Chemical class 0.000 description 2
- 229910052759 nickel Inorganic materials 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 239000012038 nucleophile Substances 0.000 description 2
- 239000012074 organic phase Substances 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- RZXMPPFPUUCRFN-UHFFFAOYSA-N p-toluidine Chemical compound CC1=CC=C(N)C=C1 RZXMPPFPUUCRFN-UHFFFAOYSA-N 0.000 description 2
- 229910052763 palladium Inorganic materials 0.000 description 2
- 239000012265 solid product Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 229910052723 transition metal Inorganic materials 0.000 description 2
- 150000003624 transition metals Chemical class 0.000 description 2
- OZHIYEINSCNALY-UHFFFAOYSA-N 1-aminobutan-1-ol Chemical compound CCCC(N)O OZHIYEINSCNALY-UHFFFAOYSA-N 0.000 description 1
- VOGGSKPTKSAXHR-UHFFFAOYSA-N 1-bromo-3-chloro-5-methoxybenzene Chemical compound COC1=CC(Cl)=CC(Br)=C1 VOGGSKPTKSAXHR-UHFFFAOYSA-N 0.000 description 1
- ORIYZUFTROJBQJ-UHFFFAOYSA-N 1-bromo-4-(difluoromethoxy)benzene Chemical compound FC(F)OC1=CC=C(Br)C=C1 ORIYZUFTROJBQJ-UHFFFAOYSA-N 0.000 description 1
- FPNVMCMDWZNTEU-UHFFFAOYSA-N 1-bromo-4-chloro-2-fluorobenzene Chemical compound FC1=CC(Cl)=CC=C1Br FPNVMCMDWZNTEU-UHFFFAOYSA-N 0.000 description 1
- AITNMTXHTIIIBB-UHFFFAOYSA-N 1-bromo-4-fluorobenzene Chemical compound FC1=CC=C(Br)C=C1 AITNMTXHTIIIBB-UHFFFAOYSA-N 0.000 description 1
- VEFGCFNCYQTPHP-UHFFFAOYSA-N 2-(3-phenylpropyl)thiophene Chemical compound C=1C=CC=CC=1CCCC1=CC=CS1 VEFGCFNCYQTPHP-UHFFFAOYSA-N 0.000 description 1
- AZCNDGAXOZWQPV-UHFFFAOYSA-N 2-(4-bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane Chemical compound O1C(C)(C)C(C)(C)OB1C1=CC=C(Br)C=C1 AZCNDGAXOZWQPV-UHFFFAOYSA-N 0.000 description 1
- WGFCNCNTGOFBBF-UHFFFAOYSA-N 2-bromopyrazine Chemical compound BrC1=CN=CC=N1 WGFCNCNTGOFBBF-UHFFFAOYSA-N 0.000 description 1
- FURHRJBOFNDYTG-UHFFFAOYSA-N 2-fluoroethanamine Chemical compound NCCF FURHRJBOFNDYTG-UHFFFAOYSA-N 0.000 description 1
- JBIJLHTVPXGSAM-UHFFFAOYSA-N 2-naphthylamine Chemical group C1=CC=CC2=CC(N)=CC=C21 JBIJLHTVPXGSAM-UHFFFAOYSA-N 0.000 description 1
- RKATWUBDSJHPEV-UHFFFAOYSA-N 3,3-difluorocyclobutan-1-amine Chemical compound NC1CC(F)(F)C1 RKATWUBDSJHPEV-UHFFFAOYSA-N 0.000 description 1
- SDXAWLJRERMRKF-UHFFFAOYSA-N 3,5-dimethyl-1h-pyrazole Chemical compound CC=1C=C(C)NN=1 SDXAWLJRERMRKF-UHFFFAOYSA-N 0.000 description 1
- ASVKKRLMJCWVQF-UHFFFAOYSA-N 3-buten-1-amine Chemical compound NCCC=C ASVKKRLMJCWVQF-UHFFFAOYSA-N 0.000 description 1
- WQYAZBFZFIUIPL-UHFFFAOYSA-N 3-fluoroazetidine Chemical compound FC1CNC1 WQYAZBFZFIUIPL-UHFFFAOYSA-N 0.000 description 1
- FAXDZWQIWUSWJH-UHFFFAOYSA-N 3-methoxypropan-1-amine Chemical compound COCCCN FAXDZWQIWUSWJH-UHFFFAOYSA-N 0.000 description 1
- LAXWLCVPJLBABV-UHFFFAOYSA-N 4,4,4-trifluorobutan-1-amine Chemical compound NCCCC(F)(F)F LAXWLCVPJLBABV-UHFFFAOYSA-N 0.000 description 1
- QHLLEZOPZRBCOY-UHFFFAOYSA-N 4-bromo-2-(trifluoromethyl)pyridine Chemical compound FC(F)(F)C1=CC(Br)=CC=N1 QHLLEZOPZRBCOY-UHFFFAOYSA-N 0.000 description 1
- DXCFWNVWQTYPOC-UHFFFAOYSA-N 4-bromo-n-methylbenzamide Chemical compound CNC(=O)C1=CC=C(Br)C=C1 DXCFWNVWQTYPOC-UHFFFAOYSA-N 0.000 description 1
- SUXIPCHEUMEUSV-UHFFFAOYSA-N 4-bromoquinoline Chemical compound C1=CC=C2C(Br)=CC=NC2=C1 SUXIPCHEUMEUSV-UHFFFAOYSA-N 0.000 description 1
- RDSIMGKJEYNNLF-UHFFFAOYSA-N 5-bromo-1-benzothiophene Chemical compound BrC1=CC=C2SC=CC2=C1 RDSIMGKJEYNNLF-UHFFFAOYSA-N 0.000 description 1
- 238000006443 Buchwald-Hartwig cross coupling reaction Methods 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- HTJDQJBWANPRPF-UHFFFAOYSA-N Cyclopropylamine Chemical compound NC1CC1 HTJDQJBWANPRPF-UHFFFAOYSA-N 0.000 description 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical class [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- DGEZNRSVGBDHLK-UHFFFAOYSA-N [1,10]phenanthroline Chemical compound C1=CN=C2C3=NC=CC=C3C=CC2=C1 DGEZNRSVGBDHLK-UHFFFAOYSA-N 0.000 description 1
- 150000001371 alpha-amino acids Chemical class 0.000 description 1
- 235000008206 alpha-amino acids Nutrition 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 150000001543 aryl boronic acids Chemical class 0.000 description 1
- 150000001503 aryl iodides Chemical class 0.000 description 1
- GMWFCJXSQQHBPI-UHFFFAOYSA-N azetidin-3-ol Chemical compound OC1CNC1 GMWFCJXSQQHBPI-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000019445 benzyl alcohol Nutrition 0.000 description 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- UFULAYFCSOUIOV-UHFFFAOYSA-N cysteamine Chemical compound NCCS UFULAYFCSOUIOV-UHFFFAOYSA-N 0.000 description 1
- 238000006114 decarboxylation reaction Methods 0.000 description 1
- 125000004988 dibenzothienyl group Chemical group C1(=CC=CC=2SC3=C(C21)C=CC=C3)* 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- JEAMWPJHRQVNFY-UHFFFAOYSA-N dioxazolidin-4-one Chemical compound O=C1COON1 JEAMWPJHRQVNFY-UHFFFAOYSA-N 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000012847 fine chemical Substances 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 150000002475 indoles Chemical class 0.000 description 1
- 150000002505 iron Chemical class 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 229960003151 mercaptamine Drugs 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- KVKFRMCSXWQSNT-UHFFFAOYSA-N n,n'-dimethylethane-1,2-diamine Chemical compound CNCCNC KVKFRMCSXWQSNT-UHFFFAOYSA-N 0.000 description 1
- VPCDQGACGWYTMC-UHFFFAOYSA-N nitrosyl chloride Chemical compound ClN=O VPCDQGACGWYTMC-UHFFFAOYSA-N 0.000 description 1
- 235000019392 nitrosyl chloride Nutrition 0.000 description 1
- 239000012434 nucleophilic reagent Substances 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 238000006464 oxidative addition reaction Methods 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 239000003504 photosensitizing agent Substances 0.000 description 1
- 238000007867 post-reaction treatment Methods 0.000 description 1
- OVPLZYJGTGDFNB-UHFFFAOYSA-N propan-2-yl carbamate Chemical compound CC(C)OC(N)=O OVPLZYJGTGDFNB-UHFFFAOYSA-N 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 150000003217 pyrazoles Chemical class 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000000844 transformation Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
- C07C209/06—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms
- C07C209/10—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms with formation of amino groups bound to carbon atoms of six-membered aromatic rings or from amines having nitrogen atoms bound to carbon atoms of six-membered aromatic rings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/18—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony as complexing atoms, e.g. in pyridine ligands, or in resonance therewith, e.g. in isocyanide ligands C=N-R or as complexed central atoms
- B01J31/1805—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony as complexing atoms, e.g. in pyridine ligands, or in resonance therewith, e.g. in isocyanide ligands C=N-R or as complexed central atoms the ligands containing nitrogen
- B01J31/181—Cyclic ligands, including e.g. non-condensed polycyclic ligands, comprising at least one complexing nitrogen atom as ring member, e.g. pyridine
- B01J31/1815—Cyclic ligands, including e.g. non-condensed polycyclic ligands, comprising at least one complexing nitrogen atom as ring member, e.g. pyridine with more than one complexing nitrogen atom, e.g. bipyridyl, 2-aminopyridine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
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Abstract
本发明公开了一种光化学铁催化合成芳胺类化合物的方法,以廉价且来源丰富的芳基溴化物和胺类化合物作为反应原料,以廉价铁盐为催化剂、联吡啶为配体,同时添加有机碱,在氩气氛围中通过光激发铁催化芳基溴化物和胺类化合物的C‑N偶联反应实现了芳胺类化合物的合成。本发明反应体系简单、操作简便、反应条件温和,后处理简单,目标化合物选择性好、收率高,避免了传统的昂贵金属催化剂以及无机碱的使用造成催化体系反应复杂、官能团兼容性差等问题,具有很好的应用价值和市场前景。
Description
技术领域
本发明属于芳胺类化合物的合成技术领域,具体涉及一种通过光化学铁催化合成芳胺类化合物的方法。
背景技术
过渡金属催化的C-N偶联反应被广泛地应用于药物和精细化学品的合成,被列为现代药物合成中20种最常用的反应之一(Org.Process Res.Dev.2014,18,1752,Org.Process Res.Dev.2019,23,1529)。基于配体调控策略,钯、镍催化的Buchwald-Hartwig胺化反应(Chem.Soc.Rev.2011,40,5068)、铜催化的Ullmann-Ma偶联反应(Chin.J.Chem.2020,38,879)得到了快速发展,为芳胺类化合物的高效合成提供了重要方法。尽管钯、镍和铜催化的偶联反应方面取得了重大进展,仍然需要发展廉价且环保的催化新方法。
铁是地球上储量丰度最高的过渡金属,而且各种铁盐和铁配合物可大规模获得并且价格低廉;同时,铁具有良好的生物兼容性,是人体必需的一种微量元素,以铁配合物为核心的金属蛋白质参与了多种重要的生命过程,因此发展铁为金属催化剂具有很好的潜力(Chem.Soc.Rev.2008,37,1108)。事实上,在过去的几十年里,铁作为催化剂已经取得了诸多令人瞩目的研究进展,被成功应用于多种化学转化。自1971年,Tamura和Kochi的开创性铁催化偶联反应发展以来,铁盐已成为许多有机转化的替代和有前途的催化剂(J.Chem.Soc.,Chem.Commun.1972,144)。因此,发展铁催化C-N偶联反应是一种绿色、可持续的新途径。2007年,Bolm(Angew.Chem.Int.Ed.2007,46,8862)课题组使用双齿氮配体(DMEDA),实现了首例铁催化芳基卤化物与N-亲核试剂的C-N偶联反应。接着,Tao(Adv.Synth.Catal.2009,351,720)和Kwang(Tetrahedron Lett.2009,50,5868)、Liu(Org.Lett.2008,10,4513)、Paul(Inorg.Chem.2019,58,1935)等人发展了脯氨酸和菲啰啉等为配体的芳基碘化物与N-亲核试剂(吡唑、吲哚等)的C-N偶联反应。为了提高铁催化芳基C-N键的高效构建,Taillefer(Angew.Chem.Int.Ed.2007,46,934)、Wakharkar(Catal.Commun.2007,8,65)、Liu(Green Chem.2010,12,276)等小组发展了Fe/Cu-双金属催化的C-N偶联反应。通过发展双齿氮配体的策略,铁催化的C-N偶联反应得到了发展,然而铁催化的C-N偶联反应通常需要高温(>100℃)、无机碱等造成官能团兼容性差,底物的适用范围有限等问题。最重要的是,Bolm和Buchwald发现铁催化的C-N偶联中微量残留的铜是主要的催化活性的物质(Chem.Soc.Rev.2012,41,979)。在此之后,使得铁催化的C-N偶联反应几乎停滞不前。
近年来,光促进有机合成反应被认为是环境友好、清洁以及可持续性的化学转化过程(Asian J.Org.Chem 2020,9,1519)。将光催化与铁催化结合,为有机合成中碳-碳键或碳-杂键的构建提供了一种新的研究策略。最近,铁催化在构建C-杂原子键的反应中取得了一些重要的研究进展。2012年,Bao(Chem.Commun.2023,59,752)课题组报道了可见光诱导铁催化的α-氨基酸与二恶唑酮的脱羧C-N偶联反应得到酰胺衍生物。2022年,Zeng(ACSCatal.2021,11,13955)课题组报道了在无光敏剂条件下,廉价的铁络合物作为催化剂,醛或苄醇与硝基芳烃在无强氧化剂或还原剂下得到酰胺衍生物。2022年,Bao(Org.Lett.2022,24,4766)课题组在无光敏剂条件下,有效地实现了光诱导铁催化芳基硼酸和二恶唑酮芳基C-N偶联反应。然而,在光与铁催化的C-N偶联反应中,以来源丰富廉价易得的芳基卤化物为亲电试剂与N-亲核试剂偶联反应的研究较少,主要原因是铁催化剂进行氧化加成通常需要低价态,高价铁催化剂进行氧化加成时比较困难。因此,调控Fe催化剂产生低价铁活性物种与芳基卤化物的氧化加成,有可能是促进芳基C-N偶联反应的关键。因此,发展使用简单易得配体,通用性的高效芳基溴化物与胺类的C-N偶联仍然十分重要。
发明内容
本发明的目的是提供一种使用廉价的铁盐与联吡啶催化体系,实现芳基溴化物与胺类化合物的C-N偶联,合成芳胺类化合物的方法。
针对上述目的,本发明所采用的技术方案是:将式I所示芳基溴化物与式II所示胺类化合物、联吡啶、铁催化剂、有机碱加入有机溶剂中,在氩气氛围中加热并光照反应,反应完后分离纯化产物,得到式III所示芳胺类化合物;
式中,Ar代表芳基、取代芳基、杂环芳基、取代杂环芳基中任意一种,具体如:苯基、噻吩基、噻唑基、吡啶基、吡唑基、哌啶基、吡嗪基、喹啉基、苯丙噻吩基、苯并呋喃基、二苯并噻吩基、喹喔啉基中任意一种,或者含C1~C6烷基、C6~环烷基、叔丁基二甲基硅氧基、磺酰基、吖啶基、哌啶基、三甲基甲硅烷基、卤素、C1~C4烷氧基、三氟甲氧基、三氟甲基、氰基、酯基、醛基、酰基、羰基、硼酯基中至少1种取代基的苯基;HNNu代表芳胺、取代芳胺、杂环芳胺、吡唑、酰胺、磺酰胺、脂肪胺中任意一种。
上述合成方法中,优选胺类化合物的用量为芳基溴化物摩尔量的1.1~2倍。
上述合成方法中,优选联吡啶的用量为芳基溴化物摩尔量的5%~20%。
上述合成方法中,优选铁催化剂为溴化亚铁、碳酸亚铁、醋酸亚铁、氯化亚铁等中任意一种,其用量为芳基溴化物摩尔量的5%~15%。
上述合成方法中,优选有机碱为1,8-二氮杂二环十一碳-7-烯(DBU)、四甲基胍(TMG)、7-甲基-1,5,7-三氮杂二环[4.4.0]癸-5-烯(MTBD)、1,2-二甲基-1,4,5,6-四氢嘧啶(DMTHPM)等中任意一种,其用量为芳基溴化物摩尔量的2~3倍。
上述合成方法中,优选有机溶剂为二甲基亚砜、甲苯、异丙醇、N,N-二甲基甲酰胺、N,N-二甲基乙酰胺中任意一种或两种。
上述合成方法中,优选在氩气氛围中,在波长为360~430nm的紫外光照射下80~90℃反应24~48小时。
本发明的有益效果如下:
本发明使用廉价的铁盐与联吡啶催化体系,在光照条件下实现芳基溴化物与胺类化合物C-N偶联反应合成芳胺类化合物。本发明反应体系简单,反应经济效益较高、对环境无害,反应后处理简单,芳胺类化合物具有收率好、官能团兼容性优异等优点,是一种简单、高效合成芳胺类化合物的方法,与目前追求环保、经济、绿色的化学概念相符合,具有非常重要的应用前景。
具体实施方式
下面结合实施例对本发明进一步详细说明,但本发明的保护范围并不仅限于这些实施例。
实施例1
在氩气氛围中,将31.4mg(0.2mmol)溴苯、29.4mg(0.4mmol)正丁胺、1.9mg(0.01mmol)联吡啶、3.5mg(0.01mmol)碳酸亚铁、67.4mg(0.6mmol)DMTHPM、2mL N,N-二甲基甲酰胺、磁子加入反应管中,在波长为390~395nm的紫外光照射下,85℃反应36小时。反应完后冷却至室温,加入饱和氯化钠水溶液和乙酸乙酯稀释萃取得到有机相,减压蒸馏有机相得到粗产物,以石油醚与乙酸乙酯体积比为100:1至10:1的混合液为淋洗剂,柱层析分离粗产物,得到结构式如下的淡黄色油状产物,其产率为95%。
所得产物的核磁波谱数据为:1H NMR(400MHz,CDCl3)δ7.17(t,J=7.6Hz,2H),6.69(dd,J=7.6,7.0Hz,1H),6.61(d,J=8.4Hz,2H),3.12(t,J=7.1Hz,2H),1.65-1.60(m,2H),1.49-1.39(m,2H),0.96(t,J=7.3Hz,3H);13C NMR(100MHz,CDCl3)δ148.7,129.4,117.2,112.9,43.8,31.9,20.5,14.0;HRMS(ESI)m/z C10H16N[M+H]+:理论值150.1277,实测值150.1279。
实施例2
本实施例中,用等摩尔4-溴苯-(三甲基甲硅烷基)苯替换实施例1中的溴苯,其他步骤与实施例1相同,得到结构式如下的淡黄色油状物,其产率为70%。
所得产物的核磁波谱数据为:1H NMR(400MHz,CDCl3)δ7.38(d,J=7.7Hz,2H),6.66(d,J=7.9Hz,2H),3.69(br,1H),3.17(m,2H),1.69-1.61(m,2H),1.53-1.42(m,2H),1.01(t,J=7.3Hz,3H),0.28(s,9H);13C NMR(100MHz,CDCl3)δ134.6,129.3,112.8,112.3,43.5,31.8,20.4,14.0,-0.7;HRMS(ESI)m/z C13H24NSi[M+H]+:理论值222.1673,实测值222.1671。
实施例3
本实施例中,用等摩尔4-溴苯硼酸频呐醇酯替换实施例1中的溴苯,其他步骤与实施例1相同,得到结构式如下的淡黄色固体产物,其产率为78%。
所得产物的核磁波谱数据为:1H NMR(400MHz,CDCl3)δ7.56(d,J=6.6Hz,2H),6.50(d,J=3.2Hz,2H),3.15-2.98(m,2H),1.54-1.50(m,2H),1.38-1.30(s,2H),1.26-1.23(m,12H),0.89-0.84(m,3H);13C NMR(100MHz,CDCl3)δ151.2,136.5,131.1,111.8,83.3,43.3,31.7,29.8,25.0,20.4,14.0;HRMS(ESI)m/z C16H27BNO2[M+H]+:理论值276.2129,实测值276.2125。
实施例4
本实施例中,用等摩尔4-溴二氟甲氧基苯替换实施例1中的溴苯,其他步骤与实施例1相同,得到结构式如下的淡黄色油状物,其产率为89%。
所得产物的核磁波谱数据为:1H NMR(400MHz,CDCl3)δ6.89(d,J=8.7Hz,2H),6.47(d,J=8.6Hz,2H),6.20(t,J=75.0Hz,1H),3.52(br,1H),3.01(t,J=7.1Hz,2H),1.63-1.44(m,4H),1.39-1.32(m,3H),0.89(t,J=7.3Hz,3H);13C NMR(100MHz,CDCl3)δ146.5,142.2,121.4,117.93(t,J=258.6Hz),113.1,44.0,31.6,20.3,13.9;19F NMR(376MHz,CDCl3)δ-79.83(s,F),-80.03(s,F);HRMS(ESI)m/z C11H16F2NO[M+H]+:理论值216.1194,实测值216.1197。
实施例5
本实施例中,用等摩尔N-甲基-4-溴苯甲酰胺替换实施例1中的溴苯,其他步骤与实施例1相同,得到结构式如下的白色固体产物,其产率为76%。
所得产物的核磁波谱数据为:1H NMR(400MHz,CDCl3)δ7.61(d,J=8.7Hz,2H),6.54(d,J=8.7Hz,2H),6.11(br,1H),4.02(br,1H),3.13(t,J=7.1Hz,2H),2.96(d,J=4.8Hz,3H),1.68-1.60(m,2H),1.47-1.40(m,2H),0.96(t,J=7.3Hz,3H);13C NMR(100MHz,CDCl3)δ168.2,151.0,128.5,122.5,111.6,43.2,31.5,26.7,20.2,13.9;HRMS(ESI)m/z C12H19N2O[M+H]+:理论值207.1492,实测值207.1496。
实施例6
本实施例中,用等摩尔4-溴氟苯替换实施例1中的溴苯,其他步骤与实施例1相同,得到结构式如下的淡黄色油状物,其产率为79%。
所得产物的核磁波谱数据为:1H NMR(400MHz,CDCl3)δ6.88(t,J=8.7Hz,2H),6.56-6.49(m,2H),3.07(t,J=7.1Hz,2H),1.60(m,2H),1.49-1.37(m,3H),0.96(t,J=7.3Hz,3H);13C NMR(100MHz,CDCl3)δ155.6(d,J=234.4Hz),144.9,115.6(d,J=22.2Hz),113.4(d,J=7.4Hz),44.3,31.6,20.3,13.9;19F NMR(376MHz,CDCl3)δ-128.59(s,F);HRMS(ESI)m/z C10H15NF[M+H]+:理论值168.1183,实测值168.1186。
实施例7
本实施例中,用等摩尔3-氯-5-甲氧基溴苯替换实施例1中的溴苯,其他步骤与实施例1相同,得到结构式如下的淡黄色油状物,其产率为76%。
所得产物的核磁波谱数据为:1H NMR(400MHz,CDCl3)δ6.28-6.31(m,2H),6.01(d,J=1.7Hz,1H),3.75(d,J=1.1Hz,3H),3.07(t,J=7.0Hz,2H),1.65-1.57(m,2H),1.48-1.39(m,3H),0.96(m,3H);13C NMR(100MHz,CDCl3)δ161.4,150.5,135.6,105.9,103.0,97.1,55.5,43.6,31.6,20.4,14.0;HRMS(ESI)m/z C11H17NOCl[M+H]+:理论值214.0993,实测值214.0996。
实施例8
本实施例中,用等摩尔2-氟-4-氯溴苯替换实施例1中的溴苯,其他步骤与实施例1相同,得到结构式如下的淡黄色油状物,其产率为78%。
所得产物的核磁波谱数据为:1H NMR(400MHz,CDCl3)δ6.93-6.82(m,2H),6.50(t,J=9.1Hz,1H),3.74(br,1H),3.03(t,J=7.1Hz,2H),1.59-1.47(m,2H),1.38-1.27(m,2H),0.88(t,J=7.3Hz,3H);13C NMR(100MHz,CDCl3)δ151.0(d,J=241.7Hz),135.8(d,J=11.6Hz),124.5(d,J=3.5Hz),120.2(d,J=9.6Hz),115.1(d,J=22.1Hz),112.3(d,J=4.3Hz),43.3,31.4,20.2,13.8;HRMS(ESI)m/z C10H14NFCl[M+H]+:理论值202.0793,实测值202.0797。
实施例9
本实施例中,用等摩尔4-溴2-三氟甲基吡啶替换实施例1中的溴苯,其他步骤与实施例1相同,得到结构式如下的淡黄色油状物,其产率为84%。
所得产物的核磁波谱数据为:1HNMR(600MHz,CDCl3)δ8.33(d,J=5.1Hz,1H),6.91(s,1H),6.66(d,J=2.1Hz,1H),5.15(br,1H),3.29(d,J=5.0Hz,2H),1.80-1.67(m,2H),1.58-1.49(m,2H),1.13-1.03(m,3H);13C NMR(100MHz,CDCl3)δ154.3,149.9,148.5(q,J=33.6Hz),121.8(q,J=274.2Hz),108.8,104.1,42.4,30.8,20.0,13.6;19F NMR(376MHz,CDCl3)δ-68.53(s,CF3);HRMS(ESI)m/z C10H14F3N2[M+H]+:理论值219.1104,实测值219.1107。
实施例10
本实施例中,用等摩尔2-溴吡嗪替换实施例1中的溴苯,其他步骤与实施例1相同,得到结构式如下的淡黄色油状物,其产率为81%。
所得产物的核磁波谱数据为:1H NMR(400MHz,CDCl3)δ7.96(s,1H),7.86(s,1H),7.77(s,1H),4.66(br,1H),3.39-3.27(m,2H),1.66-1.54(m,2H),1.48-1.37(m,2H),0.94(t,J=7.3Hz,3H);13C NMR(100MHz,CDCl3)δ154.9,142.1,132.7,131.9,41.4,31.7,20.2,13.9;HRMS(ESI)m/z C8H14N3[M+H]+:理论值152.1182,实测值152.1186。
实施例11
本实施例中,用等摩尔4-溴喹啉替换实施例1中的溴苯,其他步骤与实施例1相同,得到结构式如下的淡黄色油状物,其产率为79%。
所得产物的核磁波谱数据为:1H NMR(400MHz,CDCl3)δ8.86(d,J=3.1Hz,1H),8.15(d,J=8.5Hz,1H),7.56(t,J=8.0Hz,1H),7.47(d,J=8.4Hz,1H),7.31(dd,J=8.5,4.2Hz,1H),6.63(d,J=7.6Hz,1H),3.27(t,J=7.1Hz,2H),1.82-1.69(m,2H),1.59-1.50(m,2H),1.01(t,J=7.3Hz,3H);13C NMR(100MHz,CDCl3)δ149.8,149.2,143.8,130.4,128.6,119.2,118.3,118.1,104.5,43.9,31.4,20.4,13.9;HRMS(ESI)m/zC13H17N2[M+H]+:理论值201.1386,实测值201.1389。
实施例12
本实施例中,用等摩尔5-溴苯并噻吩替换实施例1中的溴苯,其他步骤与实施例1相同,得到结构式如下的淡黄色油状物,其产率为80%。
所得产物的核磁波谱数据为:1H NMR(400MHz,CDCl3)δ7.61(d,J=8.6Hz,1H),7.35(d,J=5.4Hz,1H),7.20-7.10(m,1H),6.98(d,J=2.3Hz,1H),6.72(dd,J=8.6,2.3Hz,1H),3.62(br,1H),3.24-3.10(m,2H),1.69-1.58(m,2H),1.51-1.43(m,2H),0.97(t,J=7.3Hz,3H);13C NMR(100MHz,CDCl3)δ146.1,141.1,129.1,126.7,123.3,122.7,114.0,104.7,44.2,31.7,20.4,13.9;HRMS(ESI)m/z C12H16NS[M+H]+:理论值206.0998,实测值206.0995。
实施例13
本实施例中,用等摩尔4-三氟甲基溴苯替换实施例1中的溴苯,用等摩尔乙胺替换实施例1中的正丁胺,其他步骤与实施例1相同,得到结构式如下的淡黄色油状物,其产率为91%。
所得产物的核磁波谱数据为:1H NMR(400MHz,CDCl3)δ7.41(d,J=8.3Hz,2H),6.59(d,J=8.3Hz,2H),3.91(br,1H),3.19(q,J=6.9Hz,2H),1.35-1.24(m,3H);13C NMR(100MHz,CDCl3)δ150.9,129.3,126.7(q,J=3.8Hz);125.2(q,J=270.2Hz),118.6(q,J=32.5Hz);111.8,38.2,14.7;HRMS(ESI)m/z C9H11NF3[M+H]+:理论值190.0838,实测值190.0834。
实施例14
本实施例中,用等摩尔4-三氟甲基溴苯替换实施例1中的溴苯,用等摩尔丁-3-烯-1-胺替换实施例1中的正丁胺,其他步骤与实施例1相同,得到结构式如下的淡黄色油状物,其产率为89%。
所得产物的核磁波谱数据为:1H NMR(400MHz,CDCl3)δ7.41(d,J=8.5Hz,2H),6.60(d,J=8.5Hz,2H),5.88-5.76(m,1H),5.24-5.10(m,2H),4.01(br,1H),3.22(t,J=6.1Hz,2H),2.41(q,J=6.7Hz,2H);13C NMR(100MHz,CDCl3)δ150.8,135.4,126.6(q,J=3.8Hz),125.4(q,J=270.1Hz),118.6(q,J=32.5Hz),117.6,112.0,42.4,33.5;HRMS(ESI)m/zC11H13NF3[M+H]+:理论值216.0995,实测值216.0998。
实施例15
本实施例中,用等摩尔4-三氟甲基溴苯替换实施例1中的溴苯,用等摩尔3-甲氧基丙胺替换实施例1中的正丁胺,其他步骤与实施例1相同,得到结构式如下的淡黄色油状物,其产率为85%。
所得产物的核磁波谱数据为:1H NMR(400MHz,CDCl3)δ7.21(d,J=7.6Hz,2H),6.58(d,J=7.7Hz,2H),3.51(t,J=5.8Hz,2H),3.35(s,3H),3.22(t,J=6.5Hz,2H),1.96-1.93(m,2H),1.28(s,9H);13C NMR(100MHz,CDCl3)δ146.2,140.1,126.1,112.6,71.4,58.9,42.1,33.9,31.7,29.6;HRMS(ESI)m/z C14H24NO[M+H]+:理论值222.1852,实测值222.1855。
实施例16
本实施例中,用等摩尔4-三氟甲基溴苯替换实施例1中的溴苯,用等摩尔2-巯基乙胺替换实施例1中的正丁胺,其他步骤与实施例1相同,得到结构式如下的淡黄色油状物,其产率为70%。
所得产物的核磁波谱数据为:1H NMR(400MHz,CDCl3)δ7.33(d,J=8.3Hz,2H),6.56(d,J=8.3Hz,2H),4.33(br,1H),3.28(t,J=6.3Hz,2H),2.70(t,J=6.2Hz,2H),2.04(s,3H);13C NMR(100MHz,CDCl3)δ150.2,126.7(q,J=3.8Hz),124.9(q,J=270.3Hz),119.2(q,J=32.6Hz),112.1,41.3,33.4,14.9;HRMS(ESI)m/zC10H13F3NS[M+H]+:理论值236.0715,实测值236.0719。
实施例17
本实施例中,用等摩尔4-三氟甲基溴苯替换实施例1中的溴苯,用等摩尔1-氨基丁醇替换实施例1中的正丁胺,其他步骤与实施例1相同,得到结构式如下的淡黄色油状物,其产率为89%。
所得产物的核磁波谱数据为:1H NMR(400MHz,CDCl3)δ7.39(d,J=8.4Hz,2H),6.59(d,J=8.4Hz,2H),3.70(t,J=5.7Hz,2H),3.18(t,J=6.4Hz,2H),1.76-1.64(m,4H);13CNMR(100MHz,CDCl3)δ150.9,126.7(q,J=3.8Hz),125.3(d,J=270.3Hz),118.7(q,J=32.5Hz),111.9,62.6,43.4,30.2,25.9;HRMS(ESI)m/z C11H15F3NO[M+H]+:理论值234.1100,实测值234.1105。
实施例18
本实施例中,用等摩尔4-三氟甲基溴苯替换实施例1中的溴苯,用等摩尔2-氟乙胺替换实施例1中的正丁胺,其他步骤与实施例1相同,得到结构式如下的淡黄色油状物,其产率为87%。
所得产物的核磁波谱数据为:1H NMR(400MHz,CDCl3)δ7.41(d,J=7.8Hz,2H),6.63(d,J=7.9Hz,2H),4.73-4.44(m,2H),4.29(s,1H),3.59-3.41(m,2H);13C NMR(100MHz,CDCl3)δ150.1,126.70(q,J=3.7Hz),124.9(d,J=270.3Hz),119.6(q,J=32.9Hz),112.2,82.1(d,J=168.0Hz),43.7(d,J=20.4Hz);HRMS(ESI)m/zC9H10NF4[M+H]+:理论值208.0744,实测值208.0749。
本实施例中,用等摩尔TMG代替MTBD,产物的产率为85%。
实施例19
本实施例中,用等摩尔4-三氟甲基溴苯替换实施例1中的溴苯,用等摩尔3-三氟甲基丙胺替换实施例1中的正丁胺,其他步骤与实施例1相同,得到结构式如下的淡黄色油状物,其产率为73%。
所得产物的核磁波谱数据为:1H NMR(400MHz,CDCl3)δ7.43(d,J=8.5Hz,2H),6.61(d,J=8.5Hz,2H),3.98(br,1H),3.26(t,J=7.0Hz,2H),2.30-2.12(m,2H),1.98-1.85(m,2H);13C NMR(100MHz,CDCl3)δ150.4,126.9(d,J=276.2Hz),126.6(q,J=3.7Hz),125.12(q,J=270.3Hz),119.3(q,J=32.6Hz),112.0,42.3,31.4(q,J=29.1Hz),22.1(q,J=2.4Hz);HRMS(ESI)m/z C11H12NF6[M+H]+:理论值272.0868,实测值272.0864。
实施例20
本实施例中,用等摩尔4-三氟甲基溴苯替换实施例1中的溴苯,用等摩尔环丙级胺替换实施例1中的正丁胺,其他步骤与实施例1相同,得到结构式如下的淡黄色油状物,其产率为89%。
所得产物的核磁波谱数据为:1H NMR(400MHz,CDCl3)δ7.42(d,J=8.3Hz,2H),6.79(d,J=8.3Hz,2H),4.44(br,1H),2.46(s,1H),0.79(d,J=6.2Hz,2H),0.54(s,2H);13C NMR(100MHz,CDCl3)δ151.3,126.6(q,J=3.7Hz),126.1(d,J=276.2Hz),119.3(q,J=32.7Hz),112.5,25.0,7.7;19F NMR(376MHz,CDCl3)δ-60.96(s,CF3);HRMS(ESI)m/zC10H11NF3[M+H]+:理论值202.0838,实测值202.0835。
实施例21
本实施例中,用等摩尔4-三氟甲基溴苯替换实施例1中的溴苯,用等摩尔3,3-二氟环丁胺替换实施例1中的正丁胺,其他步骤与实施例1相同,得到结构式如下的淡黄色油状物,其产率为83%。
所得产物的核磁波谱数据为:1H NMR(400MHz,DMSO)δ7.21(d,J=8.6Hz,2H),6.46(d,J=8.6Hz,2H),3.64(br,1H),3.39 -3.28(m,1H),3.00-2.76(m,2H),2.41-2.19(m,2H);13C NMR(100MHz,DMSO)δ150.8 126.74(q,J=3.7Hz),125.2(q,J=270.1Hz),116.78(q,J=31.9Hz),112.3,42.59(dd,J=22.7,21.1Hz),37.09(dd,J=16.8,7.3Hz),37.09(dd,J=16.8,7.3Hz);19F NMR(376MHz,DMSO)δ-59.20(s),-81.05(tq,J=13.8,6.8Hz),-81.56(dp,J=20.7,6.8Hz),-93.64--93.93(m),-94.27(ttd,J=16.4,13.4,3.4Hz);HRMS(ESI)m/zC11H11NF5[M+H]+:理论值252.0806,实测值252.0803。
实施例22
本实施例中,用等摩尔4-三氟甲基溴苯替换实施例1中的溴苯,用等摩尔3-氟氮杂环丁烷替换实施例1中的正丁胺,其他步骤与实施例1相同,得到结构式如下的淡黄色油状物,其产率为79%。
所得产物的核磁波谱数据为:1H NMR(400MHz,CDCl3)δ7.29(d,J=8.6Hz,2H),6.47(d,J=8.6Hz,2H),5.52-5.30(m,1H),4.25-4.12(m,2H),3.94(m,2H),1.31(s,9H);13C NMR(100MHz,CDCl3)δ149.0,141.0,125.9,111.7,82.85(d,J=204.3Hz),59.75(d,J=23.2Hz),33.9,31.5;HRMS(ESI)m/z C13H19NF[M+H]+:理论值208.1496,实测值208.1493。
实施例23
本实施例中,用等摩尔4-三氟甲基溴苯替换实施例1中的溴苯,用等摩尔3-羟基氮杂环丁烷替换实施例1中的正丁胺,其他步骤与实施例1相同,得到结构式如下的淡黄色油状物,其产率为79%。
所得产物的核磁波谱数据为:1H NMR(400MHz,CDCl3)δ7.44(dd,J=8.0,4.6Hz,2H),6.44(dd,J=8.0,4.6Hz,2H),4.89-4.72(m,1H),4.28-4.13(m,2H),3.81-3.71(m,2H);13C NMR(100MHz,CDCl3)δ153.3,126.4(q,J=3.4Hz),124.4(q,J=270.2Hz),119.27(q,J=32.2Hz),111.1,62.8,61.5;HRMS(ESI)m/z C10H11NOF3[M+H]+:理论值218.0787,实测值218.0790。
实施例24
本实施例中,用等摩尔4-三氟甲基溴苯替换实施例1中的溴苯,用等摩尔氨基甲酸异丙酯替换实施例1中的正丁胺,其他步骤与实施例1相同,得到结构式如下的淡黄色油状物,其产率为79%。
所得产物的核磁波谱数据为:1H NMR(400MHz,CDCl3)δ7.48(d,J=8.7Hz,2H),7.42(d,J=8.7Hz,2H),6.66(s,1H),4.96(dt,J=12.5,6.3Hz,1H),1.24(d,J=6.3Hz,6H);δ152.8,141.2,126.3(q,J=3.8Hz),125.2(q,J=64.3Hz).124.0(q,J=239.8Hz),1178.0,69.3,22.0;HRMS(ESI)m/z C11H13NF3O2[M+H]+:理论值248.0893,实测值248.0896。
实施例25
本实施例中,用等摩尔4-三氟甲基溴苯替换实施例1中的溴苯,用等摩尔3,5-二甲基吡唑替换实施例1中的正丁胺,其他步骤与实施例1相同,得到结构式如下的淡黄色油状物,其产率为77%。
所得产物的核磁波谱数据为:1H NMR(400MHz,CDCl3)δ7.45(dd,J=10.7,4.8Hz,2H),7.34(dd,J=11.1,4.6Hz,2H),5.98(d,J=6.5Hz,1H),2.30(d,J=5.7Hz,6H),1.35(d,J=7.1Hz,9H);13C NMR(100MHz,CDCl3)δ150.5,148.8,139.5,137.5,126.0,124.5,106.7,34.7,31.5,13.7,12.5;HRMS(ESI)m/z C15H21N2[M+H]+:理论值229.1699,实测值229.1695。
实施例26
本实施例中,用等摩尔4-三氟甲基溴苯替换实施例1中的溴苯,用等摩尔4-甲基苯胺替换实施例1中的正丁胺,其他步骤与实施例1相同,得到结构式如下的淡黄色油状物,其产率为80%。
所得产物的核磁波谱数据为:1H NMR(400MHz,CDCl3)δ7.19(d,J=7.7Hz,2H),6.98(d,J=7.8Hz,2H),6.89(dd,J=7.5,2.4Hz,4H),5.45(br,1H),2.21(s,3H),1.23(s,9H);13CNMR(100MHz,CDCl3)δ143.6,141.3,141.0,130.4,129.9,126.2,118.3,117.3,34.2,31.6,20.8;HRMS(ESI)m/z C17H22N[M+H]+:理论值240.1747,实测值240.1750。
实施例27
本实施例中,用等摩尔4-三氟甲基溴苯替换实施例1中的溴苯,用等摩尔4-氧三氟甲基苯胺替换实施例1中的正丁胺,其他步骤与实施例1相同,得到结构式如下的淡黄色油状物,其产率为79%。
所得产物的核磁波谱数据为:1H NMR(400MHz,CDCl3)δ7.38-7.22(m,3H),7.18-7.05(m,2H),7.04-6.96(m,3H),1.32(d,J=2.8Hz,9H);13C NMR(100MHz,CDCl3)δ145.1,142.9,139.9,126.4,124.8(t,J=258.6Hz),122.4,119.3,118.9,117.5,34.4,31.6;19FNMR(376MHz,CDCl3)δ-58.33(s,OCF3).HRMS(ESI)m/zC17H19NF3O[M+H]+:理论值310.1413,实测值310.1417。
实施例28
本实施例中用等摩尔4-三氟甲基溴苯替换实施例1中的溴苯,2-萘胺替换实施例1中正丁胺,其他步骤与实施例1相同,得到结构式如下的淡黄色油状物,其产率为81%。
所得产物的核磁波谱数据为:1H NMR(400MHz,CDCl3)δ7.70(dd,J=16.4,8.3Hz,2H),7.54(d,J=7.9Hz,2H),7.33-7.23(m,6H),7.03(d,J=8.7Hz,1H),1.41(s,9H);13C NMR(100MHz,CDCl3)δ150.4,141.3,134.1,130.6,128.7,128.1,128.0,126.4,126.2,124.6,122.2,120.1,118.2,34.8,31.6;HRMS(ESI)m/z C20H22N[M+H]+:理论值276.1747,实测值276.1743。
Claims (8)
1.一种光化学铁催化合成芳胺类化合物的方法,其特征在于:将式I所示芳基溴化物与式II所示胺类化合物、联吡啶、铁催化剂、有机碱加入有机溶剂中,在氩气氛围中加热并光照反应,反应完后分离纯化产物,得到式III所示芳胺类化合物;
式中,Ar代表芳基、取代芳基、杂环芳基、取代杂环芳基中任意一种,HNNu代表芳胺、取代芳胺、杂环芳胺、吡唑、酰胺、磺酰胺、脂肪胺中任意一种;
所述铁催化剂为溴化亚铁、碳酸亚铁、醋酸亚铁、氯化亚铁中任意一种;
所述有机碱为1,8-二氮杂二环十一碳-7-烯、四甲基胍、7-甲基-1,5,7-三氮杂二环[4.4.0]癸-5-烯、1,2-二甲基-1,4,5,6-四氢嘧啶中任意一种。
2.根据权利要求1所述的光化学铁催化合成芳胺类化合物的方法,其特征在于:所述Ar代表苯基、噻吩基、噻唑基、吡啶基、吡唑基、哌啶基、吡嗪基、喹啉基、苯丙噻吩基、苯并呋喃基、二苯并噻吩基、喹喔啉基中任意一种,或者含C1~C6烷基、C6~环烷基、叔丁基二甲基硅氧基、磺酰基、吖啶基、哌啶基、三甲基甲硅烷基、卤素、C1~C4烷氧基、三氟甲氧基、三氟甲基、氰基、酯基、醛基、酰基、羰基、硼酯基中至少1种取代基的苯基。
3.根据权利要求1或2所述的光化学铁催化合成芳胺类化合物的方法,其特征在于:所述胺类化合物的用量为芳基溴化物摩尔量的1.1~2倍。
4.根据权利要求1或2所述的光化学铁催化合成芳胺类化合物的方法,其特征在于:所述联吡啶的用量为芳基溴化物摩尔量的5%~15%。
5.根据权利要求1或2所述的光化学铁催化合成芳胺类化合物的方法,其特征在于:所述铁催化剂的用量为芳基溴化物摩尔量的5%~15%。
6.根据权利要求1或2所述的光化学铁催化合成芳胺类化合物的方法,其特征在于:所述有机碱的用量为芳基溴化物摩尔量的2~3倍。
7.根据权利要求1或2所述的光化学铁催化合成芳胺类化合物的方法,其特征在于:所述有机溶剂为二甲基亚砜、甲苯、异丙醇、N,N-二甲基甲酰胺、N,N-二甲基乙酰胺中任意一种或两种。
8.根据权利要求1或2所述的光化学铁催化合成芳胺类化合物的方法,其特征在于:所述光照反应是在波长为360~430nm的紫外光照射下80~90℃反应24~36小时。
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