CN117427077A - 用于治疗痴呆中的激越行为的包含右美沙芬化合物和奎尼丁的药物组合物 - Google Patents

用于治疗痴呆中的激越行为的包含右美沙芬化合物和奎尼丁的药物组合物 Download PDF

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Publication number
CN117427077A
CN117427077A CN202311175974.9A CN202311175974A CN117427077A CN 117427077 A CN117427077 A CN 117427077A CN 202311175974 A CN202311175974 A CN 202311175974A CN 117427077 A CN117427077 A CN 117427077A
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CN
China
Prior art keywords
dextromethorphan
quinidine
study
avp
salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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CN202311175974.9A
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English (en)
Chinese (zh)
Inventor
J·西弗特
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Avanir Pharmaceuticals Inc
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Avanir Pharmaceuticals Inc
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Application filed by Avanir Pharmaceuticals Inc filed Critical Avanir Pharmaceuticals Inc
Publication of CN117427077A publication Critical patent/CN117427077A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/49—Cinchonan derivatives, e.g. quinine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/485—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN202311175974.9A 2014-09-14 2015-09-14 用于治疗痴呆中的激越行为的包含右美沙芬化合物和奎尼丁的药物组合物 Pending CN117427077A (zh)

Applications Claiming Priority (36)

Application Number Priority Date Filing Date Title
US201462050170P 2014-09-14 2014-09-14
US62/050,170 2014-09-14
US201462061451P 2014-10-08 2014-10-08
US62/061,451 2014-10-08
US201462063122P 2014-10-13 2014-10-13
US62/063,122 2014-10-13
US201462063861P 2014-10-14 2014-10-14
US62/063,861 2014-10-14
US201462068742P 2014-10-26 2014-10-26
US62/068,742 2014-10-26
US201562111053P 2015-02-02 2015-02-02
US62/111,053 2015-02-02
US201562111590P 2015-02-03 2015-02-03
US62/111,590 2015-02-03
US201562128446P 2015-03-04 2015-03-04
US62/128,446 2015-03-04
US201562162140P 2015-05-15 2015-05-15
US62/162,140 2015-05-15
US201562165535P 2015-05-22 2015-05-22
US62/165,535 2015-05-22
US201562169997P 2015-06-02 2015-06-02
US62/169,997 2015-06-02
US201562180026P 2015-06-15 2015-06-15
US62/180,026 2015-06-15
US201562193347P 2015-07-16 2015-07-16
US62/193,347 2015-07-16
US201562205061P 2015-08-14 2015-08-14
US62/205,061 2015-08-14
US201562216636P 2015-09-10 2015-09-10
US62/216,636 2015-09-10
US201562217470P 2015-09-11 2015-09-11
US201562217142P 2015-09-11 2015-09-11
US62/217,470 2015-09-11
US62/217,142 2015-09-11
CN201580049454.0A CN107072990A (zh) 2014-09-14 2015-09-14 用于治疗痴呆中的激越行为的包含右美沙芬化合物和奎尼丁的药物组合物
PCT/US2015/049934 WO2016040930A1 (en) 2014-09-14 2015-09-14 Pharmaceutical compositions comprising a dextromethorphan compound and quinidine for the treatment of agitation in dementia

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201580049454.0A Division CN107072990A (zh) 2014-09-14 2015-09-14 用于治疗痴呆中的激越行为的包含右美沙芬化合物和奎尼丁的药物组合物

Publications (1)

Publication Number Publication Date
CN117427077A true CN117427077A (zh) 2024-01-23

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Family Applications (3)

Application Number Title Priority Date Filing Date
CN202311175974.9A Pending CN117427077A (zh) 2014-09-14 2015-09-14 用于治疗痴呆中的激越行为的包含右美沙芬化合物和奎尼丁的药物组合物
CN201580049454.0A Pending CN107072990A (zh) 2014-09-14 2015-09-14 用于治疗痴呆中的激越行为的包含右美沙芬化合物和奎尼丁的药物组合物
CN201910903770.XA Pending CN110664801A (zh) 2014-09-14 2015-09-14 用于治疗痴呆中的激越行为的包含右美沙芬化合物和奎尼丁的药物组合物

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN201580049454.0A Pending CN107072990A (zh) 2014-09-14 2015-09-14 用于治疗痴呆中的激越行为的包含右美沙芬化合物和奎尼丁的药物组合物
CN201910903770.XA Pending CN110664801A (zh) 2014-09-14 2015-09-14 用于治疗痴呆中的激越行为的包含右美沙芬化合物和奎尼丁的药物组合物

Country Status (15)

Country Link
US (3) US20190111047A1 (enExample)
EP (4) EP3932907A3 (enExample)
JP (4) JP2017531033A (enExample)
KR (1) KR20170052684A (enExample)
CN (3) CN117427077A (enExample)
AU (3) AU2015314710A1 (enExample)
CA (1) CA2960031A1 (enExample)
IL (2) IL250786A0 (enExample)
MX (3) MX2017003066A (enExample)
MY (1) MY198587A (enExample)
PH (1) PH12017500444A1 (enExample)
RU (1) RU2017112747A (enExample)
SG (2) SG11201701645WA (enExample)
TW (3) TW201613591A (enExample)
WO (1) WO2016040930A1 (enExample)

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KR20250129211A (ko) 2024-02-22 2025-08-29 단국대학교 천안캠퍼스 산학협력단 데가렐릭스를 유효성분으로 포함하는 신경 질환 예방 또는 치료용 약학적 조성물

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RU2020116666A (ru) 2020-07-31
EP3193872A1 (en) 2017-07-26
RU2017112747A (ru) 2018-10-15
TW202231278A (zh) 2022-08-16
EP3708168A3 (en) 2020-12-09
JP2021080300A (ja) 2021-05-27
IL274742A (en) 2020-07-30
JP2023105265A (ja) 2023-07-28
PH12017500444A1 (en) 2017-07-31
AU2020289733A1 (en) 2021-01-21
SG10201901242PA (en) 2019-03-28
EP3193872A4 (en) 2018-02-28
JP2020019818A (ja) 2020-02-06
EP3932907A3 (en) 2022-03-30
AU2015314710A1 (en) 2017-04-20
US20200289499A1 (en) 2020-09-17
TW201613591A (en) 2016-04-16
JP2017531033A (ja) 2017-10-19
JP7360409B2 (ja) 2023-10-12
WO2016040930A1 (en) 2016-03-17
IL250786A0 (en) 2017-04-30
EP3708168A2 (en) 2020-09-16
EP3932907A2 (en) 2022-01-05
MX2022008181A (es) 2022-08-10
US20240082237A1 (en) 2024-03-14
CN107072990A (zh) 2017-08-18
RU2017112747A3 (enExample) 2019-04-29
US20190111047A1 (en) 2019-04-18
SG11201701645WA (en) 2017-04-27
EP4166141A1 (en) 2023-04-19
CA2960031A1 (en) 2016-03-17
MY198587A (en) 2023-09-06
TW202106301A (zh) 2021-02-16
AU2022283671B2 (en) 2025-03-20
CN110664801A (zh) 2020-01-10
AU2022283671A1 (en) 2023-02-02
TWI869633B (zh) 2025-01-11
MX2021010696A (es) 2021-10-01
KR20170052684A (ko) 2017-05-12
MX2017003066A (es) 2017-09-12

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