TW201613591A - Pharmaceutical compositions comprising a DEXTROMETHORPHAN compound and QUINIDINE for the treatment of agitation in dementia - Google Patents
Pharmaceutical compositions comprising a DEXTROMETHORPHAN compound and QUINIDINE for the treatment of agitation in dementiaInfo
- Publication number
- TW201613591A TW201613591A TW104130311A TW104130311A TW201613591A TW 201613591 A TW201613591 A TW 201613591A TW 104130311 A TW104130311 A TW 104130311A TW 104130311 A TW104130311 A TW 104130311A TW 201613591 A TW201613591 A TW 201613591A
- Authority
- TW
- Taiwan
- Prior art keywords
- dementia
- quinidine
- agitation
- treatment
- pharmaceutical compositions
- Prior art date
Links
- LOUPRKONTZGTKE-LHHVKLHASA-N quinidine Chemical compound C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@H]2[C@@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-LHHVKLHASA-N 0.000 title abstract 4
- 206010012289 Dementia Diseases 0.000 title abstract 3
- 238000013019 agitation Methods 0.000 title abstract 3
- -1 DEXTROMETHORPHAN compound Chemical class 0.000 title abstract 2
- LOUPRKONTZGTKE-UHFFFAOYSA-N cinchonine Natural products C1C(C(C2)C=C)CCN2C1C(O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-UHFFFAOYSA-N 0.000 title abstract 2
- 229960001985 dextromethorphan Drugs 0.000 title abstract 2
- 229960001404 quinidine Drugs 0.000 title abstract 2
- 206010001497 Agitation Diseases 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 2
- 230000016571 aggressive behavior Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 208000024891 symptom Diseases 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/49—Cinchonan derivatives, e.g. quinine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/28—Morphinans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/485—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (17)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462050170P | 2014-09-14 | 2014-09-14 | |
| US201462061451P | 2014-10-08 | 2014-10-08 | |
| US201462063122P | 2014-10-13 | 2014-10-13 | |
| US201462063861P | 2014-10-14 | 2014-10-14 | |
| US201462068742P | 2014-10-26 | 2014-10-26 | |
| US201562111053P | 2015-02-02 | 2015-02-02 | |
| US201562111590P | 2015-02-03 | 2015-02-03 | |
| US201562128446P | 2015-03-04 | 2015-03-04 | |
| US201562162140P | 2015-05-15 | 2015-05-15 | |
| US201562165535P | 2015-05-22 | 2015-05-22 | |
| US201562169997P | 2015-06-02 | 2015-06-02 | |
| US201562180026P | 2015-06-15 | 2015-06-15 | |
| US201562193347P | 2015-07-16 | 2015-07-16 | |
| US201562205061P | 2015-08-14 | 2015-08-14 | |
| US201562216636P | 2015-09-10 | 2015-09-10 | |
| US201562217142P | 2015-09-11 | 2015-09-11 | |
| US201562217470P | 2015-09-11 | 2015-09-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW201613591A true TW201613591A (en) | 2016-04-16 |
Family
ID=55459653
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW104130311A TW201613591A (en) | 2014-09-14 | 2015-09-14 | Pharmaceutical compositions comprising a DEXTROMETHORPHAN compound and QUINIDINE for the treatment of agitation in dementia |
| TW109114123A TW202106301A (zh) | 2014-09-14 | 2015-09-14 | 用於治療失智症中躁動行為之包含右旋美索芬(dextromethorphan)化合物及奎尼丁(quinidine)的藥學組成物 |
| TW110139834A TWI869633B (zh) | 2014-09-14 | 2015-09-14 | 用於治療失智症中躁動行為之包含右旋美索芬(dextromethorphan)化合物及奎尼丁(quinidine)的藥學組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW109114123A TW202106301A (zh) | 2014-09-14 | 2015-09-14 | 用於治療失智症中躁動行為之包含右旋美索芬(dextromethorphan)化合物及奎尼丁(quinidine)的藥學組成物 |
| TW110139834A TWI869633B (zh) | 2014-09-14 | 2015-09-14 | 用於治療失智症中躁動行為之包含右旋美索芬(dextromethorphan)化合物及奎尼丁(quinidine)的藥學組成物 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US20190111047A1 (enExample) |
| EP (4) | EP4166141A1 (enExample) |
| JP (4) | JP2017531033A (enExample) |
| KR (1) | KR20170052684A (enExample) |
| CN (3) | CN117427077A (enExample) |
| AU (3) | AU2015314710A1 (enExample) |
| CA (1) | CA2960031A1 (enExample) |
| IL (2) | IL250786A0 (enExample) |
| MX (3) | MX2017003066A (enExample) |
| MY (1) | MY198587A (enExample) |
| PH (1) | PH12017500444A1 (enExample) |
| RU (1) | RU2017112747A (enExample) |
| SG (2) | SG10201901242PA (enExample) |
| TW (3) | TW201613591A (enExample) |
| WO (1) | WO2016040930A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3093290B1 (en) | 2007-05-01 | 2018-01-24 | Concert Pharmaceuticals Inc. | Morphinan compounds |
| US20180243289A1 (en) * | 2015-07-30 | 2018-08-30 | Concert Pharmaceuticals, Inc. | Deuterated morphinan compounds for treating agitation |
| US20180243291A1 (en) * | 2015-07-30 | 2018-08-30 | Concert Pharmaceuticals, Inc. | Deuterated morphinan compounds for treating agitation |
| ES2925277T3 (es) * | 2016-07-04 | 2022-10-14 | Avanir Pharmaceuticals Inc | Métodos para la síntesis de dextrometorfano deuterado |
| KR20200062078A (ko) * | 2017-05-04 | 2020-06-03 | 익스시바 게엠베하 | 신규 조성물, 조합 및 그의 방법을 갖는 표적 약물 구제 |
| US11478467B2 (en) | 2017-05-04 | 2022-10-25 | Sreenivasarao Vepachedu | Targeted drug rescue with novel compositions, combinations, and methods thereof |
| JP7582869B2 (ja) | 2018-05-18 | 2024-11-13 | アナベックス ライフ サイエンス コーポレイション | レスポンダ選択および治療の最適化されたｓｉｇｍａ－１アゴニスト方法 |
| CN114712357A (zh) * | 2019-01-07 | 2022-07-08 | 安泰赛普生物风投二代有限责任公司 | 用于治疗抑郁症的右美沙芬和安非他酮的组合 |
| EP3941469A4 (en) * | 2019-03-18 | 2022-05-18 | Avanir Pharmaceuticals, Inc. | METHODS OF TREATING NEGATIVE SYMPTOMS OF SCHIZOPHRENIA USING DEUTTERATED DEXTROMETHORPHANE AND QUINIDINE |
| CA3176234A1 (en) * | 2020-04-27 | 2021-11-04 | Sanjay Dube | Methods of treating agitation associated with alzheimer's disease |
| WO2022228363A1 (zh) * | 2021-04-27 | 2022-11-03 | 杭州剂泰医药科技有限责任公司 | 一种组合物的医药用途 |
| CN115322150B (zh) * | 2021-05-11 | 2024-05-28 | 深圳信立泰药业股份有限公司 | 氘代右美沙芬氢溴酸盐的固体及其制备方法和医药用途 |
| CN113209042A (zh) * | 2021-05-28 | 2021-08-06 | 珠海润都制药股份有限公司 | 一种氢溴酸右美沙芬硫酸奎尼丁胶囊及其制备方法 |
| WO2023076414A1 (en) * | 2021-10-27 | 2023-05-04 | Avanir Pharmaceuticals, Inc. | Methods of treating agitation associated with alzheimer's disease |
| CN116459255A (zh) * | 2022-01-19 | 2023-07-21 | 深圳信立泰药业股份有限公司 | 氘代右美沙芬与安非他酮联合在制备ad激越的药物中的用途 |
| US11730706B1 (en) * | 2022-07-07 | 2023-08-22 | Antecip Bioventures Ii Llc | Treatment of depression in certain patient populations |
| KR20250120917A (ko) | 2024-02-02 | 2025-08-11 | 단국대학교 천안캠퍼스 산학협력단 | 덱스트로메토르판을 유효성분으로 포함하는 신경 질환 예방 또는 치료용 약학 조성물 |
| KR20250129211A (ko) | 2024-02-22 | 2025-08-29 | 단국대학교 천안캠퍼스 산학협력단 | 데가렐릭스를 유효성분으로 포함하는 신경 질환 예방 또는 치료용 약학적 조성물 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3536809A (en) | 1969-02-17 | 1970-10-27 | Alza Corp | Medication method |
| US3598123A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| US4008719A (en) | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
| US5166207A (en) | 1991-06-17 | 1992-11-24 | Neurotherapeutics, Inc. | Method for enhancing the systemic delivery of dextromethorphan for the treatment of neurological disorders |
| US5350756A (en) | 1991-06-17 | 1994-09-27 | Smith Richard A | Use of a cytochrome oxidase inhibitor to increase the cough-suppressing activity of dextromorphan |
| US5366980A (en) | 1991-06-17 | 1994-11-22 | Smith Richard A | Use of dextromethorphan and an oxidase inhibitor to treat dermatitis |
| US5206248A (en) | 1992-03-27 | 1993-04-27 | Smith Richard A | Method for reducing emotional lability |
| TW264473B (enExample) * | 1993-01-06 | 1995-12-01 | Hoffmann La Roche | |
| USRE38115E1 (en) | 1994-09-22 | 2003-05-06 | Center For Neurologic Study | Dextromethorphan and an oxidase inhibitor for treating intractable conditions |
| US5874443A (en) | 1995-10-19 | 1999-02-23 | Trega Biosciences, Inc. | Isoquinoline derivatives and isoquinoline combinatorial libraries |
| US5886210A (en) | 1996-08-22 | 1999-03-23 | Rohm And Haas Company | Method for preparing aromatic compounds |
| US5922683A (en) | 1997-05-29 | 1999-07-13 | Abbott Laboratories | Multicyclic erythromycin derivatives |
| ES2352739T3 (es) | 1997-11-21 | 2011-02-22 | Purdue Neuroscience Company | 2-aminoacetamidas sustituidas y el uso de las mismas. |
| IL137974A0 (en) | 1998-03-26 | 2001-10-31 | Shionogi & Co | Indole derivatives having antiviral activity |
| US6509331B1 (en) | 1998-06-22 | 2003-01-21 | Elan Pharmaceuticals, Inc. | Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| FR2784988B1 (fr) | 1998-10-23 | 2002-09-20 | Adir | Nouveaux composes dihydro et tetrahydroquinoleiniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| TWI326214B (en) * | 2002-07-17 | 2010-06-21 | Avanir Pharmaceuticals Inc | Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of neurological disorders |
| KR20080097443A (ko) * | 2006-02-03 | 2008-11-05 | 아바니르 파마슈티컬스 | 덱스트로메토판 및 퀴니딘을 포함하는, 우울, 불안 및 신경퇴행성 장애 치료용 약제학적 조성물 |
| EP2001534A4 (en) * | 2006-03-07 | 2013-07-03 | Univ Florida | SYSTEM FOR MONITORING THE COMPLIANCE OF MEDICINAL DOSES |
| WO2008097924A2 (en) * | 2007-02-05 | 2008-08-14 | Avanir Pharmaceuticals | Pharmaceutical compositions comprising dextromethorphan analogs for the treatment of neurological disorders |
| EP3093290B1 (en) * | 2007-05-01 | 2018-01-24 | Concert Pharmaceuticals Inc. | Morphinan compounds |
| ES2401892T3 (es) * | 2007-05-01 | 2013-04-25 | Concert Pharmaceuticals Inc. | Compuestos morfinanos |
| ES2750825T3 (es) * | 2008-09-19 | 2020-03-27 | Concert Pharmaceuticals Inc | Compuestos de morfinano deuterados |
| HUE028956T2 (en) * | 2008-10-30 | 2017-01-30 | Concert Pharmaceuticals Inc | Combination of morphinan compounds and antidepressant for the treatment of pseudobulbar affect |
| MX2011005112A (es) * | 2008-11-14 | 2011-06-16 | Concert Pharmaceuticals Inc | Derivados de dioxopiperidinil-ftalimida sustituida. |
| JP6605485B2 (ja) * | 2013-11-05 | 2019-11-13 | アンテシップ バイオベンチャーズ トゥー エルエルシー | ブプロピオンまたは関連組成物およびデキストロメトルファンを含む組成物 |
-
2015
- 2015-09-14 KR KR1020177009991A patent/KR20170052684A/ko not_active Ceased
- 2015-09-14 TW TW104130311A patent/TW201613591A/zh unknown
- 2015-09-14 SG SG10201901242PA patent/SG10201901242PA/en unknown
- 2015-09-14 WO PCT/US2015/049934 patent/WO2016040930A1/en not_active Ceased
- 2015-09-14 CN CN202311175974.9A patent/CN117427077A/zh active Pending
- 2015-09-14 JP JP2017533726A patent/JP2017531033A/ja active Pending
- 2015-09-14 SG SG11201701645WA patent/SG11201701645WA/en unknown
- 2015-09-14 MX MX2017003066A patent/MX2017003066A/es unknown
- 2015-09-14 US US15/510,498 patent/US20190111047A1/en not_active Abandoned
- 2015-09-14 AU AU2015314710A patent/AU2015314710A1/en not_active Abandoned
- 2015-09-14 TW TW109114123A patent/TW202106301A/zh unknown
- 2015-09-14 EP EP22195837.4A patent/EP4166141A1/en not_active Withdrawn
- 2015-09-14 EP EP21178170.3A patent/EP3932907A3/en not_active Withdrawn
- 2015-09-14 TW TW110139834A patent/TWI869633B/zh active
- 2015-09-14 EP EP15840718.9A patent/EP3193872A4/en not_active Withdrawn
- 2015-09-14 MY MYPI2017000321A patent/MY198587A/en unknown
- 2015-09-14 CN CN201580049454.0A patent/CN107072990A/zh active Pending
- 2015-09-14 CA CA2960031A patent/CA2960031A1/en active Pending
- 2015-09-14 RU RU2017112747A patent/RU2017112747A/ru not_active Application Discontinuation
- 2015-09-14 EP EP20159783.8A patent/EP3708168A3/en not_active Withdrawn
- 2015-09-14 CN CN201910903770.XA patent/CN110664801A/zh active Pending
-
2017
- 2017-02-26 IL IL250786A patent/IL250786A0/en unknown
- 2017-03-08 MX MX2021010696A patent/MX2021010696A/es unknown
- 2017-03-08 MX MX2022008181A patent/MX2022008181A/es unknown
- 2017-03-09 PH PH12017500444A patent/PH12017500444A1/en unknown
-
2019
- 2019-10-08 US US16/596,236 patent/US20200289499A1/en not_active Abandoned
- 2019-11-06 JP JP2019201410A patent/JP2020019818A/ja not_active Withdrawn
-
2020
- 2020-05-18 IL IL274742A patent/IL274742A/en unknown
- 2020-12-15 AU AU2020289733A patent/AU2020289733A1/en not_active Abandoned
-
2021
- 2021-03-08 JP JP2021036318A patent/JP7360409B2/ja active Active
-
2022
- 2022-12-06 AU AU2022283671A patent/AU2022283671B2/en not_active Expired - Fee Related
-
2023
- 2023-04-24 US US18/305,589 patent/US20240082237A1/en not_active Abandoned
- 2023-06-12 JP JP2023096152A patent/JP2023105265A/ja active Pending
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