CN117379521A - Preparation method and application of plant cell enzymolysis extract for treating helicobacter pylori - Google Patents

Preparation method and application of plant cell enzymolysis extract for treating helicobacter pylori Download PDF

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Publication number
CN117379521A
CN117379521A CN202311309615.8A CN202311309615A CN117379521A CN 117379521 A CN117379521 A CN 117379521A CN 202311309615 A CN202311309615 A CN 202311309615A CN 117379521 A CN117379521 A CN 117379521A
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Prior art keywords
enzymolysis
helicobacter pylori
preparation
extract
stirring
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CN202311309615.8A
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Chinese (zh)
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任辛
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Individual
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment

Abstract

The invention belongs to the technical field of biological pharmacy, and particularly relates to a preparation method and application of a plant cell enzymolysis extract for treating helicobacter pylori. The fresh ginger and garlic are cleaned, peeled, mixed, crushed and sieved by a 10-20-mesh sieve to obtain a mixture for standby; according to the following steps of 1:1, adding edible grain wine into the prepared mixture, placing the mixture in an enzymolysis container, adding amylase, stirring at high speed for 20-30 minutes, stirring for 1 time every day, and continuously stirring for 5-6 days; adding cell fusion enzyme, and standing for 30-40 days; separating and purifying at normal temperature, precipitating and filtering the extract with 200 meshes according to the following ratio of 1: and (3) adding sodium carboxymethylcellulose in a mass ratio of 0.25, and mixing. The extract obtained by the invention can effectively treat and kill helicobacter pylori, has no toxic or side effect, blocks the occurrence of gastric cancer and treats gastrointestinal digestive system diseases.

Description

Preparation method and application of plant cell enzymolysis extract for treating helicobacter pylori
The application is a divisional application of a plant cell enzymolysis extract preparation method for treating helicobacter pylori, wherein the application date is 2019, 07, 05 and 201910605605.6.
Technical Field
The invention relates to the technical field of biological pharmacy, in particular to a preparation method and application of a plant cell enzymolysis extract for treating helicobacter pylori.
Background
Helicobacter pylori gram-negative bacteria, microaerophilic, are extremely tolerant to survival under extremely acidic conditions. Parasitic under the gastric mucosa of human body is a bacterial pathogen which takes gastric mucosa tissue as a nutrition source and seriously damages the gastric mucosa tissue. According to the world health organization, the authoritative organization of the digestive system department and epidemiological investigation find that: most of the world population is infected by helicobacter pylori, more than 90% of the population in some countries is infected by the helicobacter pylori, and the infection rate under 5 years old can reach 50%, the average infection rate of helicobacter pylori issued by Chinese authoritative organizations of helicobacter pylori in China reaches more than 59%, the average infection rate of helicobacter pylori under 20-40 years old reaches 63.6%, the average infection rate of helicobacter pylori under 70% can reach more than 70%, and the infection rate is also rising year by year and is maintained at a higher level. Helicobacter pylori is not only the leading cause of various stomach diseases, 67% -80% of gastric ulcers, 95% of duodenal ulcers, and 100% of chronic gastritis are caused by helicobacter pylori. At the same time, the medicine is a true source of most chronic pharyngitis (77.6%), canker sore, periodontal (84.2%), peptic ulcer, intestinal ulcer and dysbacteriosis (86%).
The poor prognosis of helicobacter pylori is gastric cancer. The poor prognosis of H.pylori accounts for 2% of H.pylori infections, in other words 2 of every 100 H.pylori infected persons will be transformed into gastric cancer, the proportion of such transformation also increases year by year and is younger, with gastric cancer patients under 35 accounting for 6% -11% of the total number of diseases. China is the country with the largest number of gastric cancer patients in the world, more than 68 tens of thousands of gastric cancer patients are added each year, the total incidence rate of gastric cancer is more than half of the global incidence rate, the death rate is very high, and 1 person dies of gastric cancer every 2 minutes (the survival rate of gastric cancer patients is less than 22% in 5 years). Most of these are in a dense and inseparable relationship with helicobacter pylori infection. Helicobacter pylori is an absolute means of transmitting infections among each other through various lifestyles. Helicobacter pylori has been listed by the world health organization as a first-order carcinogen, an absolute red light for gastric cancer, and early discovery of early treatment of helicobacter pylori is a key to preventing gastric cancer. For digestive diseases of the gastrointestinal system, the conventional treatment method at present uses a large amount of antibiotics, but the antibiotics can have side effects on human bodies, can cause the human bodies to have drug resistance and is not beneficial to the health of the human bodies.
Disclosure of Invention
The invention aims to provide a preparation method of a plant cell enzymolysis extract for treating helicobacter pylori, which is characterized in that rhizomes and fruits of edible plants are subjected to gene conversion and recombination, a cell activity enzyme conversion model is established, directional active substances in conversion enzymes are induced to release, the body surface of helicobacter pylori is targeted and combined, and the protein synthesis of the body surface of helicobacter pylori is changed. Simultaneously, the phagocytic capacity of White Blood Cells (WBC) is enhanced, the immune function of the organism is enhanced, and the serum properdin is improved, thereby having important significance for treating human infectious diseases.
In order to achieve the above purpose, the present invention provides the following technical solutions:
a preparation method of plant cell enzymolysis extract for treating helicobacter pylori comprises the following steps:
s1: cleaning fresh rhizoma Zingiberis recens and Bulbus Allii, peeling, mixing, crushing, and sieving with 10-20 mesh sieve to obtain a mixture;
s2: according to the following steps of 1:1, adding edible grain wine into the prepared mixture, placing the mixture in an enzymolysis container, adding amylase, stirring at high speed for 20-30 minutes, stirring for 1 time every day, and continuously stirring for 5-6 days;
s3: adding cell fusion enzyme into the S2, and standing for 30-40 days;
s4: separating and purifying at normal temperature, precipitating and filtering the extract with 200 meshes according to the following ratio of 1:0.25 mass percent, adding sodium carboxymethylcellulose and mixing;
in S3, the cell fusion enzyme is chitosan oligosaccharide cell fusion enzyme.
Further, in S2, the alcohol concentration of the edible grain wine for enzymolysis of ginger and garlic is 30%, and the enzymolysis temperature is not higher than 30 ℃.
In S2, the proportion of the amylase used for enzymolysis of ginger and garlic is 10% of the total amount in the enzymolysis vessel.
Further, in S3, the addition ratio of the chitosan oligosaccharide cell fusion enzyme is 1.5% of the total amount in the enzymolysis vessel.
Ginger: pungent taste, warm nature and no toxicity. Enters the lung, stomach and spleen meridians. Dispelling cold and relieving exterior syndrome; lowering the adverse flow of qi to arrest vomiting; resolving phlegm and relieving cough. The wind-cold type common cold is mainly treated; aversion to cold and fever; headache and nasal obstruction; vomiting; phlegm-fluid retention, dyspnea and cough; fullness of the body; diarrhea. Can be used for treating common cold due to wind-cold, emesis due to stomach cold, and cough due to cold phlegm. Removing odor and promoting the expression of the health.
Garlic has broad antibacterial spectrum and strong antibacterial property. The allicin has strong killing effect on gram-positive bacteria and gram-negative bacteria, can prevent atherosclerosis, protect heart from being affected, and has the functions of clearing plague, detoxication, promoting blood circulation and removing blood stasis. In addition, allicin has typical antibiotic and bactericidal properties, can treat tinea pedis (tinea pedis and dermatomycosis), has immunity function on irritant substances, and has certain curative effects on asthma, common cold, diabetes and vaginal infection. It also has antiviral, blood lipid reducing, blood pressure lowering, blood sugar reducing, platelet aggregation resisting, fibrinolytic enzyme activity improving, tumor cell inhibiting and killing effects, tumor preventing and treating effects, coronary atherosclerotic plaque reducing, blood clot resisting, health promoting, and growth promoting effects.
The ginger and the garlic are purely natural medicinal and edible plant rhizome substances, and the substances extracted after enzymolysis by the cell fusion enzyme not only keep the original functions of the ginger and the garlic (such as improving immunity, resisting oxidation, resisting aging, reducing blood fat, diminishing inflammation, sterilizing, resisting virus and the like), but also have the functions of strongly killing helicobacter pylori of a human body, blocking and reducing the incidence rate of gastric cancer, repairing gastric mucosa, gastritis, gastric ulcer and other digestive system diseases caused by the helicobacter pylori and the like. The method avoids the side effect and drug resistance of the human body brought by helicobacter pylori by using a large amount of antibiotics, can thoroughly solve the problems of digestive system diseases such as gastritis, gastric ulcer and the like which are not cured for a long time, and has important significance for improving the quality of life, happiness index and life span of human beings.
The invention provides a preparation method of a plant cell enzymolysis extract for treating helicobacter pylori, which combines the traditional Chinese medicine theory with the modern biological cell engineering technology, and fuses ginger and garlic plant cells for 30-40 days under the two actions of 10% of amylase and 1.5% of chitosan oligosaccharide cell fusion enzyme, so as to obtain a novel active small molecular peptide substance. The prepared ginger and garlic cell extract can effectively kill helicobacter pylori, has no toxic or side effect, blocks the occurrence of gastric cancer, treats gastrointestinal digestive system diseases, and greatly reduces the occurrence and recurrence probability of diseases such as gastritis, gastric ulcer, duodenal ulcer, digestive tract inflammation and the like. In addition, the preparation method is simple and convenient to operate, high in extraction rate, relatively low in production cost and suitable for industrial production or popularization.
Detailed Description
The following description of the present invention will be made clearly and fully, and it is apparent that the embodiments described are only some, but not all, of the embodiments of the present invention. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Example 1
The preparation method of the plant cell enzymolysis extract for treating helicobacter pylori comprises the following steps:
s1: cleaning fresh rhizoma Zingiberis recens and Bulbus Allii, peeling, mixing, crushing, and sieving with 20 mesh sieve to obtain a mixture;
s2: according to the following steps of 1:1, adding edible grain wine into the prepared mixture, placing the mixture into an enzymolysis container, adding amylase, stirring at high speed for 30 minutes, stirring for 1 time a day, and continuously stirring for 5 days;
wherein the alcohol concentration of the edible grain wine for enzymolysis of ginger and garlic is 30 percent, and the enzymolysis temperature is 20 ℃. The proportion of the amylase used for enzymolysis of ginger and garlic is 10% of the total amount in the enzymolysis vessel.
S3: adding cell fusion enzyme into the S2, and standing for 30 days;
wherein the cell fusion enzyme is chitosan oligosaccharide cell fusion enzyme, and the adding proportion of the chitosan oligosaccharide cell fusion enzyme is 1.5% of the total amount in the enzymolysis container.
S4: separating and purifying at normal temperature, precipitating and filtering the extract with 200 meshes according to the following ratio of 1: and (3) adding sodium carboxymethylcellulose in a mass ratio of 0.25, and mixing.
Example 2
The preparation method of the plant cell enzymolysis extract for treating helicobacter pylori comprises the following steps:
s1: cleaning fresh rhizoma Zingiberis recens and Bulbus Allii, peeling, mixing, crushing, and sieving with 20 mesh sieve to obtain a mixture;
s2: according to the following steps of 1:1, adding edible grain wine into the prepared mixture, placing the mixture into an enzymolysis container, adding amylase, stirring at high speed for 20 minutes, stirring for 1 time a day, and continuously stirring for 6 days;
wherein the alcohol concentration of the edible grain wine for enzymolysis of ginger and garlic is 30 percent, and the enzymolysis temperature is 15 ℃. The proportion of the amylase used for enzymolysis of ginger and garlic is 10% of the total amount in the enzymolysis vessel.
S3: adding cell fusion enzyme into the S2, and standing for 40 days;
wherein the cell fusion enzyme is chitosan oligosaccharide cell fusion enzyme, and the adding proportion of the chitosan oligosaccharide cell fusion enzyme is 1.5% of the total amount in the enzymolysis container.
S4: separating and purifying at normal temperature, precipitating and filtering the extract with 200 meshes according to the following ratio of 1: and (3) adding sodium carboxymethylcellulose in a mass ratio of 0.25, and mixing.
The extract of the invention can kill helicobacter pylori and treat gastrointestinal digestive system diseases, and can be prepared into pills, tablets, medicinal granules and other oral medicines, wherein the dosage is 2-3 times per day, 4-6g per time, the dosage frequency can be adjusted according to the individual infection degree, and the dosage is 10-14 days as a treatment course, and generally 2-3 treatment courses are needed.
Clinical trial:
a man is aged 49 years in diagnosis and treatment, the stomach illness is treated by the traditional Chinese medicine and the single prescription and the proved prescription for more than 40 years, but the effect is not obvious, the repeated attacks still occur, the seasonal recurrence is serious in autumn and winter, the regular pain is generated, the pain is generated when hunger is generated, the man is awakened each time, the man is in belch, tiredness and weakness are caused by belch and is pale in complexion, the hands and feet are cold, malignancy and vomit, the man is warm and loves to press, the man eats 6-8 times a day, the man eats, the man loose stool is thin, black stool frequently appears, pale tongue, deep and weak pulse, the duodenal bulb ulcer is diagnosed through the perspective of barium meal in a local hospital, the composite ulcer is weakened in constitution, the man does not participate in production for many years, the hunger pain is greatly reduced in the first course, the man is reduced to 3-4 from 6-8 meals every day, the body weight is greatly increased, the second body weight symptom is lost, the three courses are healed, the man is not cured, and the man is not cured for many years after eating for 82 days, and the man has no effect after taking for many years.
51 years old men, had complained about the stomach pain for more than twenty years, had pain after meals, acid regurgitation, heartburn, sometimes black stool, occasional hematemesis, recurrent times per year, definite diagnosis of gastric ulcer hemorrhage through local hospital barium meal perspective, loss of labor force, half a year in bed, sallow complexion, voice depression and life dangers, recovery after taking the oral medicine prepared from the cell fusion extract of the invention in three treatment courses, recheck in local hospitals, complete healing of ulcers, no scars, and no recurrence for years after follow-up.
A male is 59 years old in diagnosis and treatment, and is a compound ulcer after being checked by a plurality of hospitals after 30 years of complaints. After taking the oral medicine prepared from the cell fusion extract, three treatment courses are cured, and no recurrence is seen for years in follow-up.
After a man, 62 years old, 5 years in disease course, emaciation with yellowish complexion, bluish-purple lips, deep and thin veins and listlessness take the oral medicine prepared from the cell fusion extract disclosed by the invention, the disease is reduced by half in one course of treatment: the patient is cured after taking the medicine for two courses of treatment, and the patient does not relapse for many years after taking the medicine for follow-up.
Stomach cancer
After a male, 62 years old, symptoms of the stomach ache, bleeding, listlessness of a patient, detection by a local hospital concludes that the stomach cancer is comprehensively diagnosed at the advanced stage, and the oral medicine prepared from the cell fusion extract is taken for half a treatment course, pain stopping and blood stopping, and two half treatment courses are taken for recovery, and no recurrence is caused until the follow-up.
Some men, 62 years old, have had stomach cancer diagnosed by local hospital, have advanced stage, radiotherapy and chemotherapy are ineffective, lymphocyte is in the transfer trend, unable operation, appear as the eyeball is protruding, the body is dry like firewood, take the oral medicine that is prepared by the cell fusion extract of this invention, after taking the wolf and swallowing tiger's pharynx, the food intake is striking, follow-up two courses of treatment fully recover, follow-up visit, have not seen recrudescence for many years.
Large gastric ulcer
After a male, 53 years old, is diagnosed as a huge ulcer (ulcer surface 7cm multiplied by 8 cm) by a local hospital, and takes the oral medicine prepared from the cell fusion extract of the invention, the ulcer heals in three courses of treatment, the gastric function is recovered to be normal, and no recurrence exists in follow-up.
Pyloric obstruction
A woman, 36 years old, is diagnosed as gastric pyloric obstruction, pale complexion, bloodless lips, difficult to eat and overflow, and is cured in three treatment courses after taking the oral medicine prepared from the cell fusion extract of the invention, and no recurrence is caused in follow-up.
Gastric ulcer (gastric ulcer)
After a man, 41 years old, has undergone an operation of excision repair operation once because of gastric ulcer, needs to undergo operation again after being diagnosed by a hospital, cannot accept operation treatment because of economic difficulty, is cured in three courses of treatment after taking the oral medicine prepared by the cell fusion extract of the invention, has no recurrence after follow-up for many years, and can drink 2-5 white spirit without abnormal sensation.
The foregoing is merely illustrative of the present invention, and the present invention is not limited thereto, and any person skilled in the art will readily recognize that variations or substitutions are within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.

Claims (9)

1. A preparation method of a plant cell enzymolysis extract for treating helicobacter pylori is characterized by comprising the following steps: the preparation method comprises the following steps:
s1: cleaning fresh rhizoma Zingiberis recens and Bulbus Allii, peeling, mixing, crushing, and sieving with 10-20 mesh sieve to obtain a mixture;
s2: according to the following steps of 1:1, adding edible grain wine into the prepared mixture, placing the mixture in an enzymolysis container, adding amylase, stirring at high speed for 20-30 minutes, stirring for 1 time every day, and continuously stirring for 5-6 days;
s3: adding cell fusion enzyme into the S2, and standing for 30-40 days;
s4: separating and purifying at normal temperature, precipitating and filtering the extract with 200 meshes according to the following ratio of 1:0.25 mass percent, adding sodium carboxymethylcellulose and mixing;
in S3, the cell fusion enzyme is chitosan oligosaccharide cell fusion enzyme.
2. The method of manufacturing according to claim 1, characterized in that: in S2, the alcohol concentration of the edible grain wine for enzymolysis of ginger and garlic is 30 percent, and the enzymolysis temperature is not higher than 30 ℃.
3. The method of manufacturing according to claim 1, characterized in that: in S2, the proportion of the amylase used for enzymolysis of ginger and garlic is 10% of the total amount in the enzymolysis vessel.
4. The method of manufacturing according to claim 1, characterized in that: in S3, the adding proportion of the chitosan oligosaccharide cell fusion enzyme is 1.5% of the total amount in the enzymolysis vessel.
5. Use of the plant cell enzymolysis extract obtained by the preparation method of any one of claims 1 to 4 in the preparation of a preparation for killing helicobacter pylori.
6. Use of a plant cell enzymolysis extract obtained by the preparation method of any one of claims 1 to 4 for preparing a preparation for treating diseases caused by helicobacter pylori infection.
7. The use according to claim 6, wherein the disease caused by helicobacter pylori infection comprises one or more of gastritis, gastric ulcer, duodenal ulcer and inflammation of the digestive tract.
8. The use according to any one of claims 5 to 7, wherein the formulation comprises an oral medicament.
9. The use according to claim 8, wherein the dosage form of the orally administered medicament comprises a pill, a tablet or a granule.
CN202311309615.8A 2019-07-05 2019-07-05 Preparation method and application of plant cell enzymolysis extract for treating helicobacter pylori Pending CN117379521A (en)

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CN202311309615.8A CN117379521A (en) 2019-07-05 2019-07-05 Preparation method and application of plant cell enzymolysis extract for treating helicobacter pylori
CN201910605605.6A CN110279836A (en) 2019-07-05 2019-07-05 A kind of preparation method of plant cell enzymatic hydrolyzed extract that treating helicobacter pylori

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CN110638988A (en) * 2019-10-10 2020-01-03 湖北慎诚生命科学有限公司 Preparation method of plant cell zymolyte for killing human herpes zoster virus
CN110585327A (en) * 2019-10-10 2019-12-20 湖北慎诚生命科学有限公司 Preparation method of plant cell zymolyte for killing and inhibiting animal parvovirus
CN111437335A (en) * 2020-04-24 2020-07-24 任辛 Plant cell enzymolysis extract for killing African swine fever virus and preparation method thereof

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CN1108067A (en) * 1994-03-07 1995-09-13 张明伟 Liquid beverage (or powder) for stomachic vitality
CN104587126B (en) * 2015-01-08 2018-01-26 付永华 A kind of traditional Chinese powder medicine for treating stomach trouble
CN104651349A (en) * 2015-02-11 2015-05-27 广州赛莱拉干细胞科技股份有限公司 Method of preparing gynostemma pentaphyllum/towel gourd hybrid cell extractive and application

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