CN105250435B - A kind of compound Chinese medicinal preparation and preparation method thereof for treating influenza - Google Patents
A kind of compound Chinese medicinal preparation and preparation method thereof for treating influenza Download PDFInfo
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- CN105250435B CN105250435B CN201510739353.8A CN201510739353A CN105250435B CN 105250435 B CN105250435 B CN 105250435B CN 201510739353 A CN201510739353 A CN 201510739353A CN 105250435 B CN105250435 B CN 105250435B
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Abstract
The invention discloses a kind of compound Chinese medicinal preparation and preparation method thereof for treating influenza, raw material medicaments in part by weight number meters: 3-9 parts of honeysuckle, 3-9 parts of sarcandra, 1-5 parts of Radix Isatidis, 1-5 parts of rhizome of cyrtomium, 1-5 parts of Cordyceps militaris, Radix Glycyrrhizae 1-5 parts of mountain.The compound Chinese medicinal preparation has the function of that the symptoms such as fever, thirsty, headache, nasal congestion, pharyngalgia of coughing caused by good expelling wind to resolve the exterior, clearing heat and detoxicating, clinical studies show the composition popularity are caught a cold have significant curative effect.
Description
Technical field
The present invention relates to a kind of Chinese medicine compositions, and in particular to a kind of compound Chinese medicinal preparation for treating influenza and its
Preparation method.
Background technique
Influenza is a kind of Acute respiratory infectious disease as caused by influenza virus, and infectiousness is strong, and disease incidence is high, is
One of the important diseases of various countries' emphasis prevention and control.Currently, the best approach of anti-influenza is vaccine inoculation, influenza vaccines are for inhibition
Specific subtype influenza virus has prevention effect, and specificity is strong, has preferable control efficiency.But because influenza virus itself makes a variation
Comparatively fast, and be easy to large-scale outbreak, and Outbreak sense once occur, corresponding influenza vaccines be difficult in time research and develop and
And it is widely applied.Although and the antiviral activity of chemical drug antiviral drugs is definite, the mechanism of action is apparent, be directed to influenza kind
It is extremely limited, and as the continuous variation of virus, drug resistance phenomenon can be highlighted more, its healing is also limited to a certain extent
Effect.
Summary of the invention
The purpose of the present invention is to provide a kind of compound Chinese medicinal preparation and preparation method thereof for treating influenza, in this
Medicine compound preparation has the function of good expelling wind to resolve the exterior, clearing heat and detoxicating, clinical studies show the composition popularity flu
The symptoms such as caused fever, thirsty, headache, nasal congestion, cough pharyngalgia have significant curative effect.
To achieve the above object, the present invention adopts the following technical scheme:
A kind of compound Chinese medicinal preparation for treating influenza, raw material medicaments in part by weight number meter: 3-9 parts of honeysuckle, nine sections
3-9 parts of tea, 1-5 parts of Radix Isatidis, 1-5 parts of rhizome of cyrtomium, 1-5 parts of Cordyceps militaris, Radix Glycyrrhizae 1-5 parts of mountain.
Preparation method the following steps are included:
(1) honeysuckle, Radix Isatidis and sarcandra are weighed, 4-8 times of the sum of its weight of 50 wt.%-80wt.% ethyl alcohol are added
Solution extracts 1-2 times, 1-2 hours each, collects filtrate, is concentrated under reduced pressure into relative density 1.10-1.20 at 80 DEG C, obtains concentrate
Ⅰ；
(2) rhizome of cyrtomium and mountain Radix Glycyrrhizae are weighed, 6-10 times of the sum of its weight of purified water is added and extracts 1-3 times, each 1-3 is small
When, filtrate is collected, relative density 1.15-1.25 at 80 DEG C is concentrated under reduced pressure into, obtains concentrate II；
(3) Cordyceps militaris pulverizes, and collects the above fine powder of 80 mesh；
(4) merge concentrate I and II, Cordyceps militaris fine powder and customary adjuvant is added, be uniformly mixed, be made according to common process
Clinically acceptable dosage form.
Honeysuckle is known as clearing heat and detoxicating good medicine from ancient times.The sweet cold air fragrance of its property, clear heat with drugs of sweet flavour and cold nature is without injuring one's stomach, and fragrance is thoroughly
Up to again can eliminating evil.Honeysuckle can dispelling wind-heat, also kind removing summer-heat blood poison is used for various febrile diseases, such as body heat, dermexanthesis, macular eruption, heat
The diseases such as carbuncle carbuncle, abscess of throat, equal significant effect.
Sarcandra acrid flavour, it is mild-natured.Energy antibacterial anti-inflammatory, dispelling wind and eliminating dampness, promoting blood circulation and stopping pain.
Radix Isatidis is cold in nature, bitter after taste is first slightly sweet, has the effect of clearing heat and detoxicating, preventing cold, relieving sore-throat.It is mainly used for controlling
Treat the diseases such as the dark reddish purple dark, scarlet fever of febrile virulent maculae, tongue.
Rhizome of cyrtomium is pungent, bitter, trembles with fear.Enter lung channel, it can be clearing heat and detoxicating.For when heresy sense, partial heat person, fever weight, aversion to cold be light, headache,
Swallow red, pharynx swelling, dry and thirsty, red tongue body, thin white, the floating pulse person of tongue fur.
Cordyceps militaris not only has special nutritive value, but also has apparent medical value.Wherein especially with cordycepic acid, cordyceps sinensis
Element, Cordyceps sinensis polysaccharide.Cordycepin in Cordyceps militaris, can antiviral, antibacterial, obviously inhibition tumour growth, interference human body RNA and DNA
Synthesis.Riched Cordyceps Militaris contains cordycepic acid, cordycepic acid can effectively prophylactic treatment cerebral thrombosis, cerebral hemorrhage, renal failure, while also having
Diuresis.Adenosine in Cordyceps militaris, can antiviral, antibacterial, inhibit Platelet congregation prevent and treat thrombosis, can also eliminate face
Spot, it is anti-ageing wrinkle resistant.Cordyceps sinensis polysaccharide in Cordyceps militaris is improved immunity, delays senescence, strengthens the body resistance to consolidate the constitution, and cardioprotection, liver resist
The effect of convulsion.Ergosterol, superoxide dismutase in Cordyceps militaris, to suppressing or eliminating the superoxide radical shape for urging people's aging
At and anticancer, health care, attenuation have good action.Cordyceps militaris is also rich in selenium, and a large amount of scientific practice proves that selenium can significantly press down
The growth of cancer cell processed stimulates the generation of immunoglobulin and antibody, enhances immunity of organism and oxidation resistance.
Mountain Radix Glycyrrhizae sweet and slightly bitter taste, it is cool in nature.Major function has inducing diaphoresis, relieves summer heat, dampness removing, detoxifies, promoting blood circulation.It cures cold, heatstroke, hair
Heat, cough, abscess of throat, summer heat damp diarrhea, dysentery, sore abscess, bruise, snakebite.
Remarkable advantage of the invention is: the compound Chinese medicinal preparation has the function of good expelling wind to resolve the exterior, clearing heat and detoxicating,
The symptoms such as fever caused by clinical studies show the composition popularity is caught a cold, thirsty, headache, nasal congestion, cough pharyngalgia
There is significant curative effect.
Specific embodiment
Embodiment 1
A kind of compound Chinese medicinal preparation for treating influenza, raw material medicaments in part by weight number meter: 6 parts of honeysuckle, sarcandra 6
Part, 5 parts of Radix Isatidis, 3 parts of rhizome of cyrtomium, 3 parts of Cordyceps militaris, 1 part of mountain Radix Glycyrrhizae.
Preparation method the following steps are included:
(1) honeysuckle, Radix Isatidis and sarcandra are weighed, 4 times of the sum of its weight of 50 wt.% ethanol solutions are added and extract 1
It is secondary, 1 hour every time, filtrate is collected, relative density 1.10 at 80 DEG C is concentrated under reduced pressure into, obtains concentrate I；
(2) rhizome of cyrtomium and mountain Radix Glycyrrhizae are weighed, 6 times of the sum of its weight of purified water is added and extracts 1 time, 1 hour every time, collects filter
Liquid is concentrated under reduced pressure into relative density 1.15 at 80 DEG C, obtains concentrate II；
(3) Cordyceps militaris pulverizes, and collects the above fine powder of 80 mesh；
(4) merge concentrate I and II, Cordyceps militaris fine powder and customary adjuvant is added, be uniformly mixed, be made according to common process
Granule.
Clinical data
1, general information
Patients with influenza 97 of ZhangZhou hospital admission are selected, are grouped at random, wherein observation group 49, control group
48.Observation group male 26, women 23, average age 32.2 years old, course of disease 10-39h, average 24.3h；Control group male 25
Example, women 23, average age 33.6 years old, course of disease 10-42h, average 25.1h.Two groups of Genders, years of observation group and control group
Age, the course of disease etc. compare no difference of science of statistics (P > 0.05).
2, inclusion criteria
1. the age: 18-70 years old；2. clinical manifestation: be usually expressed as high fever (axillaty temperature >=37.5 DEG C), occur chilly,
The symptoms such as headache, dizziness, whole body ache, inability；3. diagnosing principle: in the influenza high-incidence season, there are a large amount of respiratory tract senses in this area
Dye patient or outpatient service, emergency treatment infection of the upper respiratory tract patient obviously increase, and there is corresponding clinical manifestation can be used as influenza and examine
Disconnected case.
3, exclusion criteria:
1. having diseases and pregnancy period and the breast feeding women such as severe cardiac, lung, stomach, liver；2. being inoculated with overcurrent row in 1 year
The patient of cold vaccine.
4, treatment method
Control group gives 999 Ganmaoling Granules (China Resources Sanjiu Medical & Pharmaceutical Co., Ltd.), takes orally, once a bag, one day 3
It is secondary；Compound Chinese medicinal preparation of the present invention is given by observation group, takes orally, once a bag, 3 times a day.
5, criterion of therapeutical effect
Effective: 1 day body temperature is normal after treatment, and the symptom of whole body disappears；Effective: 1-2 days body temperature is normal after treatment, whole body
Symptom disappears；Temperature changing is unobvious after treatment 2 days, and the symptom of whole body without improvement or deteriorates.
Total effective rate=obvious effective rate+effective percentage
6, result
Clinical test results are shown in Table 1, effective 32 of observation group, and effective 9, total effective rate 84%；Control group effective 8,
Effective 11, total effective rate 40%.Observation group's curative effect is apparently higher than control group, compares between two groups with statistical significance (P <
0.01).
1 observation group of table and control group efficacy result
Note: compared with the control group,**P < 0.01
Embodiment 2
A kind of compound Chinese medicinal preparation for treating influenza, raw material medicaments in part by weight number meter: 9 parts of honeysuckle, sarcandra 3
Part, 3 parts of Radix Isatidis, 1 part of rhizome of cyrtomium, 5 parts of Cordyceps militaris, 3 parts of mountain Radix Glycyrrhizae.
Preparation method the following steps are included:
(1) honeysuckle, Radix Isatidis and sarcandra are weighed, 8 times of the sum of its weight of -80wt.% ethanol solution is added and extracts 2
It is secondary, 2 hours every time, filtrate is collected, relative density 1.20 at 80 DEG C is concentrated under reduced pressure into, obtains concentrate I；
(2) rhizome of cyrtomium and mountain Radix Glycyrrhizae are weighed, 10 times of the sum of its weight of purified water is added and extracts 3 times, 3 hours every time, collects
Filtrate is concentrated under reduced pressure into relative density 1.25 at 80 DEG C, obtains concentrate II；
(3) Cordyceps militaris pulverizes, and collects the above fine powder of 80 mesh；
(4) merge concentrate I and II, Cordyceps militaris fine powder and customary adjuvant is added, be uniformly mixed, be made according to common process
Tablet.
Embodiment 3
A kind of compound Chinese medicinal preparation for treating influenza, raw material medicaments in part by weight number meter: 3 parts of honeysuckle, sarcandra 9
Part, 1 part of Radix Isatidis, 5 parts of rhizome of cyrtomium, 1 part of Cordyceps militaris, 5 parts of mountain Radix Glycyrrhizae.
Preparation method the following steps are included:
(1) honeysuckle, Radix Isatidis and sarcandra are weighed, 6 times of the sum of its weight of 65wt.% ethanol solution is added and extracts 2
It is secondary, 1.5 hours every time, filtrate is collected, relative density 1.15 at 80 DEG C is concentrated under reduced pressure into, obtains concentrate I；
(2) rhizome of cyrtomium and mountain Radix Glycyrrhizae are weighed, 8 times of the sum of its weight of purified water is added and extracts 2 times, 2 hours every time, collects filter
Liquid is concentrated under reduced pressure into relative density 1.20 at 80 DEG C, obtains concentrate II；
(3) Cordyceps militaris pulverizes, and collects the above fine powder of 80 mesh；
(4) merge concentrate I and II, Cordyceps militaris fine powder and customary adjuvant is added, be uniformly mixed, be made according to common process
Capsule.
The foregoing is merely presently preferred embodiments of the present invention, all equivalent changes done according to scope of the present invention patent with
Modification, is all covered by the present invention.
Claims (6)
1. a kind of compound Chinese medicinal preparation for treating influenza, it is characterised in that: raw material medicaments in part by weight number meter: honeysuckle
3-9 parts, 3-9 parts of sarcandra, 1-5 parts of Radix Isatidis, 1-5 parts of rhizome of cyrtomium, 1-5 parts of Cordyceps militaris, Radix Glycyrrhizae 1-5 parts of mountain.
2. the compound Chinese medicinal preparation of the treatment influenza according to claim 1, which is characterized in that bulk pharmaceutical chemicals are by weight
Measure number meter: 6 parts of honeysuckle, 6 parts of sarcandra, 5 parts of Radix Isatidis, 3 parts of rhizome of cyrtomium, 3 parts of Cordyceps militaris, 1 part of mountain Radix Glycyrrhizae.
3. the compound Chinese medicinal preparation of the treatment influenza according to claim 1, which is characterized in that bulk pharmaceutical chemicals are by weight
Measure number meter: 9 parts of honeysuckle, 3 parts of sarcandra, 3 parts of Radix Isatidis, 1 part of rhizome of cyrtomium, 5 parts of Cordyceps militaris, 3 parts of mountain Radix Glycyrrhizae.
4. the compound Chinese medicinal preparation of the treatment influenza according to claim 1, which is characterized in that bulk pharmaceutical chemicals are by weight
Measure number meter: 3 parts of honeysuckle, 9 parts of sarcandra, 1 part of Radix Isatidis, 5 parts of rhizome of cyrtomium, 1 part of Cordyceps militaris, 5 parts of mountain Radix Glycyrrhizae.
5. a kind of method of the compound Chinese medicinal preparation of the treatment influenza prepared as described in claim 1, feature exist
In:
The following steps are included:
(1) honeysuckle, Radix Isatidis and sarcandra are weighed, it is molten that 4-8 times of the sum of its weight of 50 wt.%-80wt.% ethyl alcohol are added
Liquid extracts 1-2 times, 1-2 hours each, collects filtrate, is concentrated under reduced pressure into relative density 1.10-1.20 at 80 DEG C, obtains dense
Contracting liquid I；
(2) rhizome of cyrtomium and mountain Radix Glycyrrhizae are weighed, 6-10 times of the sum of its weight of purified water is added and extracts 1-3 times, it is 1-3 hours each,
Filtrate is collected, relative density 1.15-1.25 at 80 DEG C is concentrated under reduced pressure into, obtains concentrate II；
(3) Cordyceps militaris pulverizes, and collects the above fine powder of 80 mesh；
(4) merge concentrate I and II, Cordyceps militaris fine powder and customary adjuvant is added, be uniformly mixed, be made and face according to common process
Acceptable dosage form on bed.
6. the method according to claim 5, it is characterised in that: clinically acceptable dosage form be tablet, capsule,
One of granula, pill, powder, syrup, paste, tincture, mixture.
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|---|---|---|---|---|
| CN1468629A (en) * | 2003-07-01 | 2004-01-21 | 漳州片仔癀药业股份有限公司 | Traditional Chinese medicine composition for treating wind-heat type common cold and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1468629A (en) * | 2003-07-01 | 2004-01-21 | 漳州片仔癀药业股份有限公司 | Traditional Chinese medicine composition for treating wind-heat type common cold and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 人工培养蛹虫草C19提取液的体外抗氧化活性研究;毛穗芳等;《现代食品科技》;20110131;第27卷(第1期);45-49 |
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Address after: 363000 No. 1, Amber Road, Xiangcheng District, Zhangzhou City, Fujian Province Patentee after: ZHANGZHOU PIEN TZE HUANG PHARMACEUTICAL Co.,Ltd. Address before: Xiangcheng District 363000 in Fujian province Zhangzhou City Street No. 1 Patentee before: ZHANGZHOU PIEN TZE HUANG PHARMACEUTICAL Co.,Ltd. |