CN117377455A - 包含具有优化的取代度的羧甲基纤维素（cmc）的水性个人护理组合物 - Google Patents
包含具有优化的取代度的羧甲基纤维素（cmc）的水性个人护理组合物 Download PDFInfo
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- CN117377455A CN117377455A CN202280037442.6A CN202280037442A CN117377455A CN 117377455 A CN117377455 A CN 117377455A CN 202280037442 A CN202280037442 A CN 202280037442A CN 117377455 A CN117377455 A CN 117377455A
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- personal care
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- aqueous
- carboxymethyl cellulose
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Abstract
公开了一种水性个人护理组合物，特别是水包油、油包水的护肤乳剂或悬浮剂组合物，其包含单独的0.1重量％至10重量％的低取代羧甲基纤维素(CMC)、或者0.1重量％至10重量％的低取代羧甲基纤维素与0.01重量％至10重量％的至少一种天然衍生聚合物或至少一种化石衍生聚合物，0.01重量％至60重量％的至少一种个人护理添加物和水；其中，所述低取代羧甲基纤维素具有的每葡糖酐单元的平均羧甲基取代度(DS)在约0.5至约0.7的范围中，并且其中，所述低取代羧甲基纤维素是易于生物降解的。
Description
技术领域
本公开涉及一种水性个人护理组合物，具体地，涉及包含具有优化的取代度(DS)的羧甲基纤维素(CMC)的护肤组合物及其制备方法。
背景技术
通常，个人护理产品用于改善的保湿、吸收、感觉良好的因素或增强的外观。还希望这些产品在性质上应不粘腻，耐不同温度，提供不同程度的柔润性，并保持水分。此外，护理产品应当表现出良好的流变性(即以正确的方式流动)、易于拿起或擦到皮肤上。许多天然和合成聚合物已用于改善个人护理产品的流变性。溶液中聚合物的粘度和取代度(DS)决定了它们的功能性。羧甲基纤维素(CMC)具有宽范围的分子量、粘度等级，并且是无嗅、无味且化学稳定的。CMC的物理性质，特别是粘度和溶解度，在很大程度上取决于取代度(反应性羧甲基基团的数量和取代基基团的性质)。CMC发挥了稳定剂、保护性胶体、填充剂和保水剂的功能。化妆品成分审查(CIR)专家组审查了现有的CMC毒理学数据，并得出了CMC作为化妆品成分是安全的结论。
已转让给John David Reid和George C.Daul的美国专利第2,495,767号公开了由具有0.5至1.0的DS的羧甲基纤维素纺成的连续纤维。
已转让给Diacel化学工业有限公司的美国专利第4,525,585号公开了平均取代度为0.4至1.6的羧甲基纤维素钠。
已转让给CP Kelco OY的美国专利第9,181,659号公开了具有小于约0.9的DS的羧甲基碱溶液，用于高固体纸张涂料和阻隔材料。
然而，羧甲基纤维素(CMC)的取代度越低，在水中的溶解度就越小。取代度越高，使用CMC制备的乳剂或悬浮剂就越不稳定。在这种情况下，乳剂稳定性和流变行为受到影响，使得该产品不太适合个人护理应用。因此，本领域需要一种具有优化的取代度的羧甲基纤维素的个人护理乳剂或悬浮剂，其中其在水溶液中的溶解度和稳定性不会受到影响。
发明内容
本申请的主要方面涉及一种水性个人护理组合物，其包含：(a)单独的0.1重量％至10.0重量％的低取代羧甲基纤维素(CMC)、或0.1重量％至10.0重量％的低取代羧甲基纤维素与0.01重量％至10.0重量％的至少一种天然衍生聚合物或至少一种化石衍生聚合物的组合；(b)0.01重量％至60重量％的至少一种个人护理添加物；和(c)水；其中，所述低取代羧甲基纤维素具有的每葡糖酐单元的平均羧甲基取代度(DS)在约0.5至约0.7的范围中；其中，所述低取代羧甲基纤维素是易于生物降解的。
本申请的另一方面提供了一种水性护肤悬浮剂组合物，其包含：(a)单独的0.1重量％至10.0重量％的低取代羧甲基纤维素(CMC)、或0.1重量％至10.0重量％的低取代羧甲基纤维素与0.01重量％至10.0重量％的至少一种天然衍生聚合物或至少一种化石衍生聚合物的组合；(b)0.01重量％至60重量％的至少一种护肤添加物；和(c)水；其中，所述低取代羧甲基纤维素具有的每葡糖酐单元的平均羧甲基取代度(DS)在约0.5至约0.7的范围中；其中，所述低取代羧甲基纤维素是易于生物降解的。
本申请的另一方面提供了一种水性护肤水包油或油包水乳剂组合物，其包含：(a)单独的0.1重量％至10.0重量％的低取代羧甲基纤维素(CMC)、或0.1重量％至10.0重量％的低取代羧甲基纤维素与0.01重量％至10.0重量％的至少一种天然衍生聚合物或至少一种化石衍生聚合物的组合；(b)0.01重量％至60重量％的至少一种护肤添加物；和(c)水；其中，所述低取代羧甲基纤维素具有的每葡糖酐单元的平均羧甲基取代度(DS)在约0.5至约0.7的范围中，其中，所述低取代羧甲基纤维素是易于生物降解的。
本申请的另一个方面提供了一种制备水性个人护理组合物的方法，所述方法包括：(a)考虑包含单独的低取代羧甲基纤维素(CMC)、或包含低取代羧甲基纤维素与至少一种天然衍生聚合物或化石衍生聚合物的组合的粉末颗粒；(b)在连续混合下将所述聚合物粉末分散在水中；和(c)获得均质的水性组合物。
附图说明
除了本公开所引用的优点和目的之外，可以通过参考在附图中示出的本公开的某些实施方案来添加本公开的一个或多个简单概述的描述。这些附图构成了说明书的一部分。然而，应注意的是，所附附图示出了本公开的优选实施方案，并因此不限制其范围。
图1示出了比较性的CMC与本发明的CMC样品等级的粘度数据。
图2示出了比较性的CMC与本发明的CMC样品等级的悬浮剂研究。
图3示出了比较性的CMC与本发明的CMC-鲸蜡基(cetyl)HEC组合物等级的粘度数据。
图4示出了本发明的CMC与电解质和矿物质的相容性。
具体实施方式
结合下文具体实施方案，将清楚地描述和更好地理解本公开的技术方案，但是本领域技术人员将会理解，下文描述的实施方案只是本公开的实施方案的一部分，而不是全部，并且仅用于阐明本公开，而不应视为限制本公开的范围。如果在实施例中未指明任何具体的条件或方法，应该理解，这些条件是制造商通常使用的，并且是可商购的。
如根据本公开所使用的，除非另有说明，否则以下术语应理解为具有以下含义。
除非本文另有定义，否则与所公开和/或要求保护的发明构思相关的技术术语应具有本领域普通技术人员通常理解的含义。此外，除非上下文另有要求，否则单数术语应包括复数，复数术语应包括单数。
单数形式的“a”、“an”(一)和“所述”包括复数形式，除非上下文明确指出另有规定或引用的上下文中有相反的明确暗示。术语“包含/包括(comprising/comprises of)”包括更具限制性的权利要求，例如“基本上由……组成”和“由……组成”。
出于以下详细描述的目的，除了在任何操作实例中，或在另有说明的情况下，表示例如说明书和权利要求中使用的成分的量的数字应理解为在所有情况下由术语“约”修饰。说明书和所附权利要求中列出的数值参数是近似值，可以根据在实施本发明时所要获得的期望性质而变化。
除非另有说明，本文所用的所有百分比、份数、比例和比率均以总组合物的重量计。所有这些与所列成分相关的重量都是基于活性水平，因此，除非另有规定，否则不包括可商购材料中可能包含的溶剂或副产品。
本文引用的所有出版物、文章、论文、专利、专利出版物和其他参考文献均出于所有目的在与本文公开内容一致的程度上整体并入本文。
如本文所用，术语“至少一个”将理解为包括一个以及多于一个的任何数量，包括但不限于1、2、3、4、5、10、15、20、30、40、50、100等。术语“至少一个”可以延伸到最高达100或1000或更多，这取决于其所附的术语。此外，100/1000的数量不应认为是限制性的，因为更低或更高的限制也可以产生令人满意的结果。
如本文所用，术语“烷基多苷”在整个说明书中以缩写形式“APG”指代，是指非离子型表面活性剂。少数非限制性实例包括椰油葡糖苷、癸基葡糖苷和十二烷基葡糖苷。
如本文所用，术语“包含/包括(comprising)”(及其任何形式，例如“包含/包括(comprise)”和“包含/包括(comprises)”)、“具有(having)”(及其任何形式，例如“具有(have)”和“具有(has)”)、“包含/包括(including)”(及其任何形式，例如“包含/包括(includes)”和“包含/包括(include)”)或“含有(containing)”(及其任何形式，例如“含有(contains)”和“含有(contain)”)是包含性的或开放式的，并且不排除额外的、未列出的要素或方法步骤。
如本文所用，在包括附图的整个说明书中所使用的术语“优化的羧甲基纤维素CMC”、“低取代羧甲基纤维素”、“羧甲基纤维素”、“CMC”、“纤维素胶”或“生物纤维素”或“生物凝胶”或“样品等级”或“本发明的样品”是可互换的，并且是指具有在0.5至0.7范围中的取代度的羧甲基纤维素的钠盐。
如本文所用，术语“化妆品可接受的”是指被认为是安全的、经监管机构批准的、在药典中列出的用于与组织(例如皮肤)局部接触而没有过度毒性、不相容性、不稳定性、刺激性、过敏反应等的分子实体。该术语不旨在限制其描述的仅用作化妆品的组合物(例如，该组合物可用作药物)。
如本文所用，术语“取代度(DS)”或“取代的程度(substituted degree)”或“取代程度(substitution degree)”通常是指羧甲基纤维素的每葡糖酐单元中取代的羧甲基基团的平均数。每个葡糖酐(β-吡喃葡萄糖)单元有三个反应性(羟基)基团，因此理论上DS值可以在0(纤维素本身)至3(完全取代的纤维素)的范围中。使用NMR通过鉴定葡糖酐单元和酸酐基团中甲基的质子和碳位移来测量位置和DS。
如本文所用，术语“聚合物”是指包含通过共价化学键连接的重复结构单元(单体)的化合物。聚合物可以进一步衍生、交联、接枝或封端。聚合物的非限制性实例包括共聚物、三元共聚物、四元共聚物、季聚合物和同系物。术语“共聚物”是指基本上由两种或更多种不同类型的单体组成的聚合物，该单体聚合以获得所述共聚物。
如本文所用，术语“个人护理组合物”和“化妆品”是指旨在用于人体如皮肤、头发、口腔之上或之中的组合物，包括那些改变皮肤和头发的颜色和外观的组合物。
如本文所用，术语“溶液粘度”或“平均粘度”是指其抵抗由剪切应力引起的逐渐形变的量度，所述剪切应力是由分子间内聚力引起的。这些力受一些因素如浓度、温度或取代度的影响。
如本文所用，术语“流变学”是指“针对事物如何流动的科学或研究”，是个人护理产品的必备条件。
如本文所用，在说明书和附图中所指的术语“样品等级”或“样品”涉及本发明的具有0.5至0.7的取代度的羧甲基纤维素钠。
如本文所用，术语“黄原胶”是指在工业上能够改变液体流变性的多糖胶。任何可商购的黄原胶都可以用于本发明。合适的商业黄原胶包括但不限于Xanthan(来自Kelco的/>)或/>(来自R.T.Vanderbilt)。
合成流变改性剂(如卡波姆(carbomer))传统上用于有效地增稠和稳定具有吸引人的美感的护肤乳剂。现有的天然流变改性剂通常具有非常差的美感，使得很难创造出消费者想要开发的天然的、可持续的制剂，通过我们在可持续来源的纤维素方面的市场领先的专业知识，结合我们的流变改性经验，本发明人试图引入一种可持续的替代品。
在一个非限制性实施方案中，本公开涉及一种水性个人护理组合物，其包含：(a)单独的0.1重量％至10重量％的低取代羧甲基纤维素(CMC)，或0.1重量％至10重量％的低取代羧甲基纤维素与0.01重量％至10重量％的至少一种天然衍生聚合物或至少一种化石衍生聚合物的组合；(b)0.01重量％至60重量％的至少一种个人护理添加物；和(c)水；其中，低取代羧甲基纤维素具有的每葡糖酐单元的平均羧甲基取代度(DS)在约0.5至约0.7的范围中；其中，所述低取代羧甲基纤维素是易于生物降解的。
CMC是一种可生物降解的、高度相容的阴离子聚合物，其通过用羧甲基醚基团取代纤维素分子中的至少一部分羟基而由纤维素(天然来源于棉绒、木浆或其他纤维素化合物)获得。
羧甲基纤维素是通过纤维素与单氯乙酸钠的碱化反应获得的商业(CMC)，其取代度(DS)在0.4至1.3的范围中。DS高于0.4的CMC是完全可溶解的，并且CMC的亲水性(hydroaffinity)随着DS的增加而增加，而这种聚合物在DS低于0.4时是可溶胀但不可溶解的。
在另一个非限制性实施方案中，本发明的纤维素是纤维素的聚羧基甲基醚，并且在碱性溶液中自发地转化成钠盐(CMC钠)。纤维素胶(即羧甲基纤维素钠)的取代度在0.5至0.7的范围中。根据生物降解能力标准，OECD指南，301D试验，具有相似结构和物理性质的CMC在28天后观察到的生物降解为71％。本发明的“纤维素胶”是一种被评估为易于生物降解的生物纤维素。
羧甲基纤维素以总个人护理组合物的约0.1重量％至约10.0重量％的浓度范围存在。天然衍生聚合物或化石衍生聚合物以总个人护理组合物的约0.01重量％至约10.0重量％的浓度范围存在。该护理组合物另外包含0.01重量％至10重量％的护理添加物和水。
在另一个非限制性实施方案中，低取代羧甲基纤维素以固体颗粒或粉末的形式存在，在1％水性溶液中具有平均粘度范围为约2500至约8500cps、或约8500至16000cps、或约16000至约120000cps的高粘度，如通过Brookfield，转子A，速度5所测量)。
纤维素化合物的分子量通过GPC/SEC分析来确定。凝胶渗透色谱(GPC)，也称为尺寸排阻色谱(SEC)，是表征聚合物分子量、平均分子量和分子量分布的重要工具。出于本发明的目的，所有分子量都以重均分子量(Mw)给出，且以道尔顿(Da)计。在本发明的实施方案中，羧甲基纤维素的重均分子量将在约1000,000至约2000,000道尔顿的范围中。
本发明组合物中使用的天然衍生聚合物可选自包括但不限于以下的组：黄原胶、瓜尔胶、角豆胶、魔芋胶、小核菌胶、阿拉伯胶、纤维素胶、普鲁兰多糖、微晶纤维素、羧甲基淀粉钠、羟丙基淀粉磷酸酯、疏水改性的羟乙基纤维素(HMHEC)例如鲸蜡硬脂基(cetearyl)羟乙基纤维素、刺云实胶、卡拉胶、脱氢黄原胶、改性马铃薯淀粉、葡甘露聚糖、硅酸镁铝、膨润土、改性玉米淀粉、聚酯基聚合物和结冷胶。优选地，天然衍生聚合物是黄原胶。黄原胶是一种以多聚葡萄糖作为主要的聚合物主链的多糖，其具有3-单元乙酰化侧链，包括葡萄糖、葡萄糖醛酸(通常作为混合的钾盐、钠盐和钙盐存在)和甘露糖残基。黄原胶聚合物通常获自细菌发酵，特别是野油菜黄单胞菌(Xanthomonas campestris)和相关微生物的发酵。
可用于实施本发明的化石衍生聚合物包括丙烯酸酯基聚合物、甲基丙烯酸酯基聚合物、马来酸酐基聚合物、聚酯基聚合物、聚氨酯基聚合物、或乙烯基吡咯烷酮基聚合物。合适的丙烯酸酯或丙烯酸烷基酯包括但不限于(甲基)丙烯酸、(甲基)丙烯酸甲酯、(甲基)丙烯酸乙酯、(甲基)丙烯酸丙酯、(甲基)丙烯酸异丙酯、(甲基)丙烯酸丁酯、(甲基)丙烯酸戊酯、(甲基)丙烯酸异丁酯、(甲基)丙烯酸叔丁酯、(甲基)丙烯酸戊烷酯、(甲基)丙烯酸异戊酯、(甲基)丙烯酸己酯、(甲基)丙烯酸庚酯、(甲基)丙烯酸辛酯、(甲基)丙烯酸异辛酯、(甲基)丙烯酸2-乙基己酯、(甲基)丙烯酸壬酯、(甲基)丙烯酸癸酯、(甲基)丙烯酸异癸酯、(甲基)丙烯酸十一烷基酯、(甲基)丙烯酸十二烷基酯、(甲基)丙烯酸月桂酯、(甲基)丙烯酸十八烷基酯和(甲基)丙烯酸硬脂酯；(甲基)丙烯酸烷氧基烷基酯，特别是(甲基)丙烯酸d-烷氧基d-烷基酯，例如丙烯酸丁氧基乙酯和丙烯酸乙氧基乙氧基乙酯；(甲基(eth))丙烯酸芳氧基烷基酯，特别是(甲基)丙烯酸芳氧基C4烷基酯，例如丙烯酸苯氧基乙酯、单环和多环环状芳族丙烯酸酯或非芳族丙烯酸酯例如丙烯酸环己基酯、丙烯酸苄酯、丙烯酸二环戊二烯酯、丙烯酸二环戊基酯、丙烯酸三环癸酯、丙烯酸冰片酯、丙烯酸异冰片酯，醇基(甲基)丙烯酸酯例如聚乙二醇单丙烯酸酯、聚丙二醇单丙烯酸酯、甲氧基乙二醇丙烯酸酯、甲氧基聚丙二醇丙烯酸酯、甲氧基聚乙二醇丙烯酸酯、乙氧基二甘醇丙烯酸酯，以及各种烷氧基化烷基酚丙烯酸酯例如乙氧基化(4)壬基酚丙烯酸酯，(甲基)丙烯酸的氨基化合物例如二丙酮丙烯酰胺、异丁氧基甲基丙烯酰胺、叔辛基丙烯酰胺。
此外，化石衍生聚合物包括内酰胺，但不限于N-乙烯基吡咯烷酮、N-乙烯基己内酰胺、N-甲基-吡咯烷酮、N-羟甲基吡咯烷酮、N-羟乙基吡咯烷酮和N-羟丙基吡咯烷酮。代表性的酸酐包括甲酸酐、琥珀酸酐、马来酸酐和乙酸酐。优选的化石衍生聚合物包括用癸二烯和聚丙烯酸交联的甲基乙烯基醚/马来酸酐共聚物。
本发明组合物中使用的合适的防腐剂可以是选自包括肉桂醛、有机酸、覆盆子酮、麝香草酚、丁香酚、柠檬醛、单月桂酸甘油酯、山竹醇、和凹叶厚朴(Magnolia officinalis)的超临界流体提取物(包括木兰醇和和厚朴酚)的组的天然防腐剂，或选自包括对羟基苯甲酸酯类、苯氧乙醇、甲醛、氯化鲸蜡基吡啶苄索氯铵、苯扎氯铵、聚氨基丙基双胍、2-溴-2-硝基-1,3-二醇、丁基氨基甲酸碘丙炔基酯(IPBC)、咪唑烷基脲、双咪唑烷基脲、苯甲醇中的苯甲酸和山梨酸的组的合成防腐剂。对羟基苯甲酸酯类包括对羟基苯甲酸甲酯、对羟基苯甲酸乙酯和对羟基苯甲酸丙酯。
本发明组合物中使用的合适的表面活性剂可以是本质上天然的和合成的非离子型或离子型。非离子型表面活性剂包括烷基多苷，其也称为“APG”。烷基多苷是天然来源的表面活性剂，主要包含淀粉和椰子油；并且是100％可生物降解的。
本发明组合物中使用的合适的保湿剂包括二醇类、丙三醇类(glycerols)、丙二醇、二甘醇单乙醚、山梨醇、焦谷氨酸钠盐、丙三醇(glycerol)、丙三醇衍生物、甘油(glycerin)、海藻糖、山梨醇、麦芽糖醇、二丙二醇、1,3-丁二醇、透明质酸钠等。
从天然来源或合成来源获得的香精或芳香剂可用于本发明的个人护理组合物中。芳香剂可以与合适的溶剂、稀释剂或载体一起使用。芳香剂可以以任何常规已知的方法加入，例如，与组合物混合或与用于形成组合物的其他成分混合，以被发现可用于增加或赋予消毒剂或清洁组合物所需的香味特征的量加入。用于本申请的芳香剂可以是选自以下化合物的非限制性组的一种或多种，例如精油、净油、树脂状物质(resinoids)、树脂、冷凝脂、烃类、醇类、醛类、酮类、醚类、酸类、酯类、缩醛类、缩酮类、腈类，包括饱和化合物和不饱和化合物以及脂肪族化合物、羧基化合物和杂环化合物。本申请中使用的优选香精或芳香剂包括香茅醇、己基肉桂醛、柠檬烯、素馨花(Jasminum grandiflorum flower)提取物、香叶醇和芳樟醇。
在另一个非限制性实施方案中，将本发明的个人护理组合物配制成护发品、洗发剂、发调理剂、免洗型调理剂和冲洗型调理剂、发定型组合物、烫发品、发松弛剂、直发剂、喷发胶和喷发定型剂、永久性染发体系、发定型摩丝、发胶、半永久性染发体系、临时性染发体系、漂发体系、永久性烫发体系、发定型制剂、液体皂剂、条皂剂、芳香和/或有气味的成分组成的制品、除臭和止汗制品、身体油剂、身体洗剂、身体凝胶剂、治疗霜剂、身体清洁品、皮肤保护软膏剂、剃须和须后制品、爽肤粉、唇膏、粉底、甲油、眼影、睫毛膏、干性和湿性化妆品、胭脂或腮红、粉剂、脱毛剂、免洗型皮肤洗剂和霜剂、沐浴凝胶剂、卫生间条形皂、无阳光美黑剂、防晒洗剂、防晒喷剂、防晒霜剂、发定型凝胶剂、精华、膜剂(mask)和牙膏。
在另一个非限制性实施方案中，单独的低取代CMC或低取代CMC的组合用于制备乳剂、分散剂、悬浮剂、洗剂、霜剂、泡沫剂、喷剂、凝胶剂、条皂剂、棒剂、膜剂、垫剂或贴剂形式的个人护理组合物。
在另一个非限制性实施方案中，包含低取代羧甲基纤维素的个人护理制剂的平均粘度为约20,000至约30,000cps、或约30,000至约50,000cps、或约40,000至约60,000cps、或约50,000至约70,000cps、或约110,000至130,000cps、或约150,000至约200,000cps、或约200,000至约250,000cps、或约220,000至约260,000cps。
所述乳剂是水包油乳剂或油包水乳剂。目前的水包油乳剂是稳定的，可以赋予高粘度并为消费者带来美感和感官特性。当用于个人护理应用时，采用多种添加物为最终的个人护理产品提供多种额外的益处。
在另一个非限制性实施方案中，本发明涉及一种水性护肤悬浮剂组合物，其包含：(a)单独的0.1重量％至10.0重量％的低取代羧甲基纤维素(CMC)，或0.1重量％至10.0重量％的低取代羧甲基纤维素与0.01重量％至10.0重量％的至少一种天然衍生聚合物或化石衍生聚合物的组合；(b)0.1重量％至60.0重量％的至少一种护肤添加物；和(c)水；其中，所述低取代羧甲基纤维素具有的每葡糖酐单元的平均羧甲基取代度(DS)在约0.5至约0.7的范围中。
悬浮剂用于悬浮水性溶液中的颗粒。这些颗粒可以选自封装有活性材料的珠、captivates。这些胶囊(encapsulate)是一系列包含活性成分或核心材料的小颗粒，其由外壳包裹，并使用复合凝聚工艺生产。它们在胶囊(capsule)壁厚度、颜色、胶囊尺寸和核心材料方面有所不同。这些胶囊增强视觉效果，递送香味，提供质地、感官信号，隔离并保护成分，悬浮糖、盐、硅和其他剥离(exfoliant)剂。优选的胶囊是captivates GL和captivatesHC胶囊。CaptivatesTMhc胶囊是一系列尺寸范围为250μm至3,000μm的小颗粒，其包含活性成分或核心材料，由外壳包裹，采用复合凝聚工艺生产。胶囊壁厚度、颜色、胶囊尺寸和核心材料均可定制。CaptivatesTMgl胶囊是一系列尺寸范围为5μm至2,000μm的小颗粒，其包含分散在连续基质中的材料。这些微珠采用JettCutterTM技术制成，其形成一种可以包埋(entrap)不可溶解的粉末、油类和水可溶解的活性物质的水凝胶基质。
制剂中还可包含几种其他成分，以改善其性质和功能。出于该目的，可以加入一种或多种选自包括库拉索芦荟(Aloe barbadensis)叶汁(CMC可抵抗电解质)和甘油的组的保湿剂，一种或多种选自包括树莓(Rubus idaeus)(覆盆子)籽油、温州蜜柑(citrus unshiu)皮提取物和咖啡因提取物的组的抗氧化剂，一种或多种选自甘油或乙基己基甘油的调理剂；一种或多种选自覆盆子酮、1,2-己二醇和苯氧乙醇的防腐剂的增效剂，以改善产品的整体性能。
水凝胶是一种多功能感官增强剂，可轻松创建保湿护肤制剂。本申请在制剂中包括天然成分或天然来源的成分，例如LubrajelTM-INCI名称-水(和)甘油(和)PCA钠(和)赤藓糖醇(和)角叉菜胶(和)黄原胶、源自沙漠植物库拉索芦荟(Aloe Vera)的库拉索芦荟(AloeBarbadensis)汁粉末，用于抗炎和有效的皮肤保湿效果。
在另一个非限制性实施方案中，本公开涉及一种水性护肤水包油或油包水乳剂组合物，其包含：(a)单独的0.1重量％至10.0重量％的低取代羧甲基纤维素(CMC)、或0.1重量％至10.0重量％的低取代羧甲基纤维素与0.01重量％至10.0重量％的至少一种天然衍生聚合物或至少一种化石衍生聚合物的组合；(b)0.01重量％至60.0重量％的至少一种护肤添加物；和(c)水；其中，所述低取代羧甲基纤维素具有的每葡糖酐单元的平均羧甲基取代度(DS)在约0.5至约0.7的范围中。
乳剂体系具有两个互不相容的相，其中一相分散或悬浮在另一相中。好的乳剂的关键特征是保持两相不混溶，且不会分离成两个不同的相。乳化剂(emulsifier)用于减缓分离过程。乳化剂的加入有助于将固体分散在液体中或与其他液体不可溶解的液体中。这些乳化剂或乳化剂(emulsifying agent)是表面活性剂，并且是本领域所周知的。本公开采用阴离子型乳化剂、两性乳化剂和两性离子型乳化剂。阴离子型乳化剂可选自包括乙氧基化烷基硫酸盐但不限于以下的组：烷基乙氧基羧酸盐、烷基甘油醚磺酸盐、酰基肌氨酸盐、烷基乙氧基磺基琥珀酸盐、α-磺化脂肪酸及它们的盐和/或酯、乙氧基化烷基磷酸酯、乙氧基化烷基甘油醚磺酸盐、石蜡磺酸盐和烷氧基酰胺磺酸盐、烷基硫酸盐(alkylsulphates)、烷基醚硫酸盐、烷芳基磺酸盐、烷酰基羟乙基磺酸盐、烷基琥珀酸盐、烷基磺基琥珀酸盐、N-烷基肌氨酸盐、烷基醚磷酸盐、烷基醚羧酸盐、α-烯烃磺酸盐、烷基硫酸盐(salts of alkyl sulfates)、烷基苯磺酸盐、二烷基磺基琥珀酸盐、烷基磷酸盐、聚氧乙烯烷基醚硫酸盐、单硬脂酸甘油酯、烷基胺氧化物、山梨醇酐单棕榈酸酯、聚氧乙烯鲸蜡基醚、聚氧乙烯硬脂酸酯、聚氧乙烯山梨醇酐单月桂酸酯及其混合物。烷基基团和酰基基团通常含有6至22个碳原子，并且可以是不饱和的。非离子型乳化剂可选自包括以下的组：烷基葡糖苷，烷基聚糖苷，多羟基脂肪酸酰胺，烷氧基化糖酯和烷氧基化聚酯，脂肪酸酰胺，环氧烷烃(alkylene oxide)和脂肪酸的缩合产物例如脂肪酸的环氧酯和脂肪酸的环氧二酯，环氧烷烃和脂肪醇的缩合产物例如PEG 40氢化蓖麻油、PEG硬脂酸酯、月桂醇聚醚、PEG月桂醇聚醚酯、PEG硬脂酸醚、硬脂醇聚醚2、异鲸蜡醇聚醚-20和油醇聚醚-20，环氧烷烃和脂肪酸与脂肪醇的缩合产物(其中聚环氧烷烃部分的一端用脂肪酸酯化，另一端用脂肪醇醚化)，聚氧乙烯烷基醚，聚氧乙烯烷基苯基醚，聚氧乙烯脂肪酸酯，山梨醇酐脂肪酸酯，聚氧乙烯山梨醇酐脂肪酸酯，甘油脂肪酸酯和蔗糖脂肪酸酯和聚山梨醇酯。两性乳化剂选自包括以下的组：椰油酰两性羧基丙酸盐(coco ampho carboxypropionate)、椰油酰两性羧基丙酸、椰油酰两性乙酸盐、椰油两性二乙酸盐、月桂酰两性乙酸钠、N-酰氨基丙基-N,N-二甲基铵甜菜碱和N-酰氨基丙基-N,N′-二甲基-N′-2-羟丙基铵甜菜碱。两性离子型乳化剂选自包括以下的组：烷基甜菜碱和酰氨基甜菜碱、磺基甜菜碱(sultaines)、烷基甘氨酸盐、烷基羧基甘氨酸盐、烷基两性丙酸盐、烷基两性甘氨酸盐、烷基酰氨基丙基羟基磺基甜菜碱(sulfaines)、酰基牛磺酸盐(acyl taurates)、酰基谷氨酸盐，以及阳离子表面活性剂的实例包括卤化铵化合物(包括具有亲水取代基的那些)。卤化铵化合物的实例是长链烷基三甲基氯化铵、长链烷基苄基二甲基氯化铵、烷基胺盐酸盐、烷基胺乙酸盐和二(长链烷基)二甲基溴化铵。烷基基团和酰基基团具有8至19个碳原子。优选的乳化剂包括太阳花磷脂基、不含聚乙二醇(PEG)的植物基、源自溶解在甘油中的大豆的溶血磷脂酰胆碱(LPC)、鲸蜡硬脂醇和鲸蜡硬脂基葡糖苷、以及甘油硬脂酸酯柠檬酸酯&聚甘油-3硬脂酸酯&氢化卵磷脂、聚甘油-3甲基葡萄糖二硬脂酸酯、鲸蜡硬脂醇(和)硬脂酸甘油酯(和)霍霍巴酯类(和)向日葵(helianthus annuus)(太阳花)籽蜡(和)硬脂酰谷氨酸钠(和)水(和)聚甘油-3、聚甘油-3二柠檬酸酯/硬脂酸酯、硬脂酸(和)山嵛醇(和)硬脂酸甘油酯(和)肉豆蔻醇(和)月桂醇(和)鲸蜡醇(和)棕榈酸(和)卵磷脂、甘油柠檬酸酯/乳酸酯/亚油酸酯/油酸酯、聚甘油-6硬脂酸酯(和)聚甘油-6山嵛酸酯。
所述乳剂还含有水和在化妆品和/或皮肤病学领域常用的额外的助剂，包括但不限于防腐剂、芳香剂、填充剂、遮蔽剂、络合剂、精油、染料、亲水活性剂或亲脂活性剂、脂囊泡、维生素B化合物、维生素E化合物、维生素C化合物、维生素D化合物、肽、糖胺、蛋白酶抑制剂、防晒剂、脱屑剂、螯合剂、亮肤化合物、非维生素抗氧化剂自由基清除剂、植物甾醇、植物激素、蛋白酶抑制剂、酪氨酸酶抑制剂、抗炎剂、局部麻醉剂、抗脂肪团剂、无阳光美黑剂、N-酰基氨基酸化合物、及其衍生物和混合物。本公开的乳剂可用于身体、颈部和面部、眼睛等的皮肤上，包括用于幼儿皮肤和用于包括眼部周围的卸妆。
在另一个非限制性实施方案中，本发明的制剂可以采用一种或多种个人护理添加物，所述个人护理添加物选自由以下组成的组：花生醇、花生醇葡糖苷、尿囊素、库拉索芦荟(Aloe Barbadensis)叶汁粉末、山嵛醇、双-硬脂氧基二甲基硅烷、双-乙基己氧基苯酚、芸苔属甘油酯、乳木果(牛油果)油、苯甲醇、角叉菜胶(卡拉胶)、辛酸/癸酸甘油三酯(和)大花蕙兰(兰花)、棕榈(巴西棕榈)蜡、椰油葡糖苷、曲序香茅(cymbopogon flexuosus)叶油、鲸蜡硬脂醇(和)鲸蜡硬脂基葡糖苷、硼硅酸钙钠、captivates GL或captivates HC、香茅醇、鲸蜡醇乳酸酯、癸基葡糖苷、二甲基硅氧烷、己二酸二异丙酯、乙基纤维素、对羟基苯甲酸乙酯、赤藓糖醇、水杨酸乙基己酯、小烛树(蜡大戟)蜡、乙基己基三嗪酮、棕榈酸乙基己酯、果糖、明胶、葡萄糖、丙烯酸甘油酯/丙烯酸共聚物、甘油硬脂酸酯柠檬酸酯(和)聚甘油-3硬脂酸酯(和)氢化卵磷脂、甘油、甘油柠檬酸酯乳酸酯/亚油酸酯/油酸酯、水解棉籽提取物、肌醇、向日葵(太阳花)、啤酒花(蛇麻子)提取物、1,2-己二醇、月桂酸异戊酯、对羟基苯甲酸甲酯异癸酯、异鲸蜡醇硬脂酰氧基硬脂酸酯、霍霍巴酯类、素馨花提取物、对羟基苯甲酸甲酯、马来酸化大豆油、甘油十二烷醇酯/辛基十二烷醇酯、南美牛奶藤(Marsdenia Cundurango)树皮提取物、甲氧基苯基三嗪、七水合硫酸镁、新戊酸酯、辛基十二烷醇硬脂酸酯、山梨酸钾、苯氧乙醇、对羟基苯甲酸丙酯、聚香茅醇乙酸酯、聚甘油-3蜂蜡、聚甘油-6聚羟基硬脂酸酯、聚甘油-6聚蓖麻醇酸酯、覆盆子酮、PCA钠、苯甲酸钠、蔗糖、白檀(檀香木)木材提取物、EDTA四钠、蜂花烷基PVP、三乙氧基辛酰基硅烷、生育酚乙酸酯、海藻糖和氧化锌。
在另一个非限制性实施方案中，本公开涉及一种用于制备水性个人护理组合物的方法，所述方法包括：(a)考虑包含单独的低取代羧甲基纤维素(CMC)、或包含低取代羧甲基纤维素与至少一种天然衍生聚合物或化石衍生聚合物的组合的粉末颗粒；(b)在连续混合下将所述粉末分散在水中；(c)对混合溶液进行加热，以便更快地处理；以及(c)获得均质的水性组合物。所述均质的水性组合物可以是水包油乳剂、油包水乳剂、珠悬浮剂或粉末悬浮剂。
所述水包油乳剂是凝胶剂、身体洗剂、软身体霜、天然光感精华、天然海洋保湿剂、冷冻膜剂、层状凝胶面霜、清洁型泥膜剂、半固体霜剂、矿物基防晒霜剂、日新(dailyrenewal)防晒霜剂、液体剂、面部洗剂、粉底霜剂或睫毛膏制剂。
本发明的羧甲基纤维素钠盐(在本文中称为纤维素胶)是天然衍生的、可生物降解的增稠剂，其具有保持皮肤和防晒用的霜剂、洗剂和凝胶剂的稳定性的悬浮能力，具有期望的肤感和质地，提供了卡波姆的替代品。它具有>84％的天然衍生成分含量，易于生物降解，经COSMOS-验证，非GMO，适合纯素食者，干净，简单的INCI可持续来源：来自零毁林行为的FSC和PEFC认证供应商的木质纤维素。
本发明的纤维素胶带来了多种益处，包括：(i)有效的增稠和悬浮特性：有效的增稠、悬浮能力，乳剂稳定剂，并且能够形成清澈的(clear)的配方；(ii)期望的肤感和质地：与最常见的天然增稠剂相比，令人愉快的使用后肤感，改善的美感；(iii)配方多功能性：耐电解质和矿物质，在宽的pH范围(4-8)有效，无需中和，可冷加工，与其他天然衍生聚合物相容。所有这些特征使得本发明的纤维素胶成为配方师的优选选择。已经观察到了在免洗型护肤和护发应用中的极好的结果。
此外，通过以下实施例对本申请的某些方面进行详细说明。本文给出的实施例是为了说明本申请，而不是旨在限制本申请。
实施例
实施例1：羧甲基纤维素样品等级
表1-CMC样品等级
实施例2：水性悬浮剂组合物
实施例3：悬浮稳定性研究的结果
对实施例2中描述的水性悬浮剂进行悬浮研究。结果如图2所示。据观察，1.5％的商业CMC、较少量的本发明CMC样品等级(0.5％和1.0％)要么保持在溶液的底部，要么保持在溶液的顶部，并且在室温下不会悬浮超过24小时。本发明样品等级即使在较高浓度(1.5％)下也能在45℃下保持悬浮三个月。CMC的浓度决定了悬浮剂的稳定性。
实施例4：水包油乳剂的制备
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实施例5：乳剂稳定性研究的结果
使用不同的乳化剂对使用本发明CMC等级制备的水包油乳剂进行稳定性研究，并与使用商业CMC等级制备的乳剂进行比较。结果如下表2所示。
表2-水包油乳剂稳定性的结果
据观察，使用足够量的本发明CMC等级制备的乳剂比那些使用商业CMC等级制备的乳剂更稳定，商业CMC已损坏，并因此不太稳定。
实施例6：水包油乳剂的制备
使用羧甲基纤维素和下面提供的成分来制备水包油乳剂。
实施例7：乳剂稳定性研究的结果
使用多种乳化剂对如实施例6中使用本发明CMC等级制备的水包油乳剂进行稳定性研究，并与使用商业CMC样品制备的乳剂进行比较。详情见下表3。
表3-水包油乳剂研究的结果
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使用基于鲸蜡硬脂醇和鲸蜡硬脂基葡糖苷的非离子型天然乳化剂和本发明的CMC样品制备的乳剂显示出改善的乳剂稳定性。
实施例8：水包油乳剂型凝胶霜剂
使用化石衍生聚合物、低取代CMC组合和以下成分来制备油水乳剂型凝胶霜剂。
实施例9：油包水乳剂
使用以下成分来制备油包水乳剂型凝胶霜剂。
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实施例10：纯(simply)天然身体洗剂
制备了包含单一聚合物和低乳化剂的水包油乳剂型天然身体洗剂，成分列于下表。
如通过Brookfield RVT，转子B，5RPM，1分钟@25℃所测量的，这样制备的纯天然身体洗剂具有30,000-50,000cps的粘度，并通过了2个月的加速实验室研究。
实施例11：软身体霜
制备了包含低量的combo HMHEC和高乳化剂的软身体霜，成分列于下表。
如通过Brookfield RVT，转子C，5RPM，1分钟@25℃所测量的，该乳霜具有110,000-130,000cps的粘度，并通过了3个月的加速实验室研究。
实施例12：天然光感精华
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如通过Brookfield RVT，转子B，5RPM，1分钟@25℃所测量的，这样制备的天然光感精华具有40,000-60,000cps的粘度，并通过了3个月的加速实验室研究。
实施例13：天然海洋保湿剂
使用以下成分来制备水包油天然保湿剂。
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如通过Brookfield RVT，转子B，5RPM，1分钟@25℃所测量的，这样制备的天然海洋保湿剂具有50,000-70,000cps的粘度，并还通过了2个月的加速实验室研究且通过了28天的功效挑战测试。
实施例14：冷冻膜剂
使用以下成分来制备具有乙醇相容性的珍珠悬浮液的冷冻膜剂。
如通过Brookfield RVT，转子B，5RPM，1分钟@25℃所测量的，这样制备的冷冻膜剂具有20,000-30,000cps的粘度，并还通过了1个月的加速实验室研究。
实施例15：感受爱(feel the love)面霜
使用以下成分来制备包含中等量HMHEC和中等乳化剂的水包油(O/W)层状凝胶体系。
如通过Brookfield RVT，转子C，5RPM，1分钟@25℃所测量的，这样制备的感受爱面霜具有150,000-200,000cps的粘度，并且还通过了2个月的加速实验室研究。
实施例16：清洁型泥膜剂
使用以下成分制备包含combo HMHEC的具有粘土相容性的水包油层状凝胶体系。
如通过Brookfield RVT，转子D，5RPM，1分钟@25℃所测量的，这样制备的清洁型泥膜剂具有220,000-260,000cps的粘度，并且还通过了1个月的加速实验室研究和28天的挑战功效测试。
实施例17：半固体霜剂
使用大量combo HMHEC和以下成分的水包油层状凝胶体系的半固体霜剂。
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如通过Brookfield RVT，转子C，5RPM，1分钟@25℃所测量的，这样制备的半固体霜剂具有200,000-250,000cps的粘度，并且还通过了1个月的加速实验室研究和28天的挑战功效测试。
实施例18：矿物基霜剂SPF 50
使用以下成分制备包含HMHEC，以及与矿物相容的油/水层状凝胶体系。
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实施例19：日新SPF 30霜剂
使用以下成分制备包含黄原胶和有机UV过滤剂的组合的防晒霜剂。
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实施例20：液体o/w乳剂
使用以下成分制备包含硅酸镁铝的液体o/w乳剂。
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实施例21：面部洗剂
使用以下成分制备与颜料相容的o/w乳剂型面部洗剂。
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实施例22：粉底霜剂
使用以下成分制备与颜料相容的o/w乳剂型粉底霜剂。
/>
实施例23：睫毛膏制剂
使用以下成分制备与颜料相容的o/w乳剂型睫毛膏。
实施例24：纤维素浓度研究：APG冲洗剂体系制备包含以下成分的APG冲洗剂体系的多种样品
表4
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实施例25：冲洗剂体系中的APG盐浓度研究
制备包含以下成分的APG冲洗剂盐。
使用上述冲洗剂盐制备包含以下成分的APG冲洗剂盐的多种制剂样品。
表5
实施例26：冲洗剂-CAPB单一表面活性剂
制备包含以下成分的单一表面活性剂椰油酰胺丙基甜菜碱(CAPB)的冲洗剂。
表6
据观察，纤维素胶是相容的，并且确实增稠了仅有CAPB的体系。进一步检查了它与APG的组合使用，以确定其是否能组合成更复杂的体系。更高水平的CAPB不会导致更高的粘度。
实施例27：冲洗剂-APG体系-悬浮液
使用以下组合物制备APG冲洗剂的悬浮液。
表7
GL 7606珠-50％身体洗剂在藻酸盐和琼脂基质中
尽管已就重要方面描述了所公开和/或要求保护的发明构思的组合物和方法，但对本领域普通技术人员来说显而易见的是可对本文所述的组合物和/或方法以及方法的步骤或步骤顺序进行变化，而不脱离所公开和/或要求保护的发明构思的构思、精神和范围。对本领域技术人员来说显而易见的所有这些类似的替代和修改均被认为是在所公开和/或要求保护的发明构思的精神、范围和构思内。
Claims (18)
1.一种水性个人护理组合物，其包含：
(a)单独的0.1重量％至10.0重量％的低取代羧甲基纤维素(CMC)、或0.1重量％至10.0重量％的低取代羧甲基纤维素与0.01重量％至10.0重量％的至少一种天然衍生聚合物或至少一种化石衍生聚合物的组合；和
(b)0.01重量％至60重量％的至少一种个人护理添加物；和
(c)水，
其中，所述低取代羧甲基纤维素具有的每葡糖酐单元的平均羧甲基取代度(DS)在约0.5至约0.7的范围中；以及
其中，所述低取代羧甲基纤维素是易于生物降解的。
2.根据权利要求1所述的水性个人护理组合物，其中所述天然衍生聚合物选自由以下组成的组：黄原胶、瓜尔胶、角豆胶、魔芋胶、小核菌胶、阿拉伯胶、纤维素胶、普鲁兰多糖、微晶纤维素、羧甲基淀粉钠、疏水改性的羟乙基纤维素、羟丙基淀粉磷酸酯、刺云实胶、卡拉胶、脱氢黄原胶、改性马铃薯淀粉、葡甘露聚糖、硅酸镁铝、膨润土、改性玉米淀粉、聚酯基聚合物和结冷胶。
3.根据权利要求1所述的水性个人护理组合物，其中所述天然衍生聚合物是黄原胶。
4.根据权利要求1所述的水性个人护理组合物，其中所述化石衍生聚合物是丙烯酸酯基聚合物、甲基丙烯酸酯基聚合物、马来酸酐基聚合物、聚氨酯基聚合物、聚酯基聚合物或乙烯基吡咯烷酮基聚合物。
5.根据权利要求1所述的水性个人护理组合物，其中所述低取代CMC为固体颗粒或粉末的形式。
6.根据权利要求1所述的水性个人护理组合物，其中所述低取代CMC在1％水性溶液中具有在约2500cps至约20000cps的范围中的平均粘度。
7.根据权利要求1所述的水性个人护理组合物，其中所述低取代CMC具有在约1000000道尔顿至约2000000道尔顿的范围中的分子量。
8.根据权利要求1所述的水性个人护理组合物，其中所述组合物是乳剂、分散剂、悬浮剂、洗剂、霜剂、泡沫剂、喷剂、凝胶剂、条皂剂、棒剂、膜剂、垫剂或贴剂。
9.根据权利要求8所述的水性个人护理组合物，其中
所述乳剂是水包油乳剂或油包水乳剂；以及
所述悬浮剂是珠悬浮剂或粉末悬浮剂。
10.根据权利要求9所述的水性个人护理组合物，其中所述水包油乳剂是凝胶剂、身体洗剂、软身体霜、天然光感精华、天然海洋保湿剂、冷冻膜剂、层状凝胶面霜、清洁型泥膜剂、半固体霜剂、矿物基防晒霜剂、日新防晒霜剂、液体剂、面部洗剂、粉底霜剂或睫毛膏制剂。
11.根据权利要求10所述的水性个人护理组合物，其中所述凝胶剂是稳定的，赋予高粘度并为消费者带来美感。
12.根据权利要求1所述的水性个人护理组合物，其中将所述个人护理组合物配制成护发品、洗发剂、发调理剂、免洗型调理剂、发定型组合物、烫发品、发松弛剂、直发剂、喷发胶和喷发定型剂、永久性染发体系、发定型摩丝、发胶、半永久性染发体系、临时性染发体系、漂发体系、永久性烫发体系、发定型制剂、液体皂剂、条皂剂、芳香和/或有气味的成分组成的制品、除臭和止汗制品、身体油剂、身体洗剂、身体凝胶剂、治疗霜剂、身体清洁品、皮肤保护软膏剂、剃须和须后制品、爽肤粉、唇膏、粉底、甲油、眼影、睫毛膏、干性和湿性化妆品、胭脂、粉剂、脱毛剂、免洗型皮肤洗剂和霜剂、沐浴凝胶剂、卫生间条形皂、无阳光美黑剂、防晒洗剂、防晒喷剂、防晒霜剂、发定型凝胶剂、精华、膜剂、防晒洗剂、洁齿剂和牙膏。
13.根据权利要求1所述的水性个人护理组合物，其中所述低取代羧甲基纤维素是易于生物降解的，根据OECD测试方法-301D所表征的，其在28天后生物降解71％。
14.一种制备水性个人护理组合物的方法，所述方法包括：
(a)考虑包含单独的权利要求1(a)的低取代羧甲基纤维素(CMC)或包含所述低取代羧甲基纤维素与至少一种天然衍生聚合物或至少一种化石衍生聚合物的组合的粉末颗粒；
(b)在连续混合下将所述粉末分散在水中；
(c)对混合溶液进行加热，以便更快地处理；以及
(d)获得均质的水性组合物。
15.根据权利要求14所述的方法，其中所述均质的水性组合物是水包油乳剂或油包水乳剂。
16.一种水性护肤乳剂组合物，其包含：
(a)单独的0.1重量％至10重量％的权利要求1(a)的低取代羧甲基纤维素(CMC)，或0.1重量％至10重量％的所述低取代羧甲基纤维素与0.01重量％至10重量％的至少一种天然衍生聚合物或至少一种化石衍生聚合物的组合；
(b)0.01重量％至60重量％的至少一种护肤添加物；和
(c)水；
其中，所述低取代羧甲基纤维素具有的每葡糖酐单元的平均羧甲基取代度(DS)在约0.5至约0.7的范围中；其中，所述低取代羧甲基纤维素是易于生物降解的。
17.根据权利要求16所述的水性护肤组合物，其中所述乳剂是水包油乳剂或油包水乳剂。
18.根据权利要求16所述的水性护肤乳剂，其中所述护肤添加物选自维生素B化合物、维生素E化合物、维生素C化合物、维生素D化合物、肽、糖胺、蛋白酶抑制剂、防晒剂、脱屑剂、螯合剂、亮肤化合物、非维生素抗氧化剂自由基清除剂、植物甾醇、植物激素、蛋白酶抑制剂、酪氨酸酶抑制剂、抗炎剂、局部麻醉剂、抗脂肪团剂、无阳光美黑剂、N-酰基氨基酸化合物、防腐剂、防腐促进剂、甘油、乙二醇、它们的衍生物及其混合物。
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| US4401813A (en) * | 1981-12-10 | 1983-08-30 | Nl Industries, Inc. | Process for preparing alkali metal salt of carboxymethyl cellulose |
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| CN102356093A (zh) * | 2009-03-31 | 2012-02-15 | 陶氏环球技术有限责任公司 | 具有改进性质的羧甲基纤维素 |
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