CN117356707A - Functional food composition for preventing and treating three-high symptoms and preparation method thereof - Google Patents

Functional food composition for preventing and treating three-high symptoms and preparation method thereof Download PDF

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CN117356707A
CN117356707A CN202311413503.7A CN202311413503A CN117356707A CN 117356707 A CN117356707 A CN 117356707A CN 202311413503 A CN202311413503 A CN 202311413503A CN 117356707 A CN117356707 A CN 117356707A
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parts
treating
functional food
preventing
preparation
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王峰
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Taiyi Hepu Beijing Research Institute Of Tcm Co ltd
Shanghai Daosheng Medical Tech Co Ltd
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Taiyi Hepu Beijing Research Institute Of Tcm Co ltd
Shanghai Daosheng Medical Tech Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
    • A23L19/09—Mashed or comminuted products, e.g. pulp, purée, sauce, or products made therefrom, e.g. snacks
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
    • A23L19/10—Products from fruits or vegetables; Preparation or treatment thereof of tuberous or like starch containing root crops
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/20—Agglomerating; Granulating; Tabletting
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Abstract

The invention discloses a functional food composition for preventing and treating three-high symptoms, which is prepared from the following medicinal materials in parts by weight: 3 to 750 parts of hawthorn, 3 to 600 parts of sea buckthorn, 6 to 450 parts of fragrant solomonseal rhizome, 4 to 450 parts of kudzuvine root, 8 to 525 parts of honeysuckle, 2 to 600 parts of dandelion, 3 to 450 parts of perilla, 5 to 750 parts of radish seed, 3 to 600 parts of dried ginger and 6 to 450 parts of chrysanthemum. The raw materials in the formula of the invention adopt medicinal and edible plant medicines, so that not only can the three-high symptoms be prevented and treated, but also the intravascular garbage can be removed, the cell vitality can be enhanced, the purpose of health care can be achieved, and the health care concept of 'green health' can be met. The invention also discloses a preparation method of the functional food granule and the ointment for preventing and treating the three-high disease.

Description

Functional food composition for preventing and treating three-high symptoms and preparation method thereof
Technical Field
The invention relates to a functional food composition for preventing and treating three-high symptoms. The invention also relates to a preparation method of the functional food composition for preventing and treating the three-high symptoms.
Background
The concept of "three highs" is now known by more people, and generally refers to three conditions closely related to sub-health, namely hyperlipidemia, hyperglycemia and hypertension, and the health problems caused by the changes of life type and eating habits are not only faced by the elderly, but also the problems of hypertension, diabetes, stroke and the like of more and more twenty to fifty-year old people in advance due to higher blood pressure, higher blood sugar and higher cholesterol. Hyperlipidemia can cause atherosclerosis thrombosis, and further develop into cerebral infarction; hypertension can cause cerebral hemorrhage and cerebral vascular rupture; hyperglycemia can cause renal failure and retinopathy.
The three highs are not independent, but closely related and mutually influenced, so that as long as one disease is suffered, the other two diseases are quickly brought up: patients with diabetes are prone to hypertension or hyperlipidemia; hyperlipidemia is the "root" and "accelerator" of atherosclerosis; the atherosclerosis aggravates the rise of blood pressure due to poor vascular elasticity, causing hypertension.
The three-high disease is associated with hands, so that organs such as heart, liver, brain, kidney and the like are damaged together, various complications are induced, cardiovascular and cerebrovascular diseases and renal failure can be seriously caused, even death is caused, and a plurality of people smell the three-high disease color change.
In clinic, western medicines are generally used for reducing blood pressure, blood sugar and blood lipid at present, and the medicines have large side effects, so that the aim of treating both principal and secondary aspect of disease can not be achieved, and some medicines also have drug withdrawal reaction, so that pain is increased for people.
Disclosure of Invention
The invention aims to solve the technical problem of providing a functional food composition for preventing and treating three-high symptoms, which uses Chinese herbal medicines with homology of medicine and food and can prevent and treat the three-high symptoms by regulating the function balance of a human body.
In order to solve the technical problems, the technical solution of the functional food composition for preventing and treating the three-high disease is that the functional food composition is prepared from the following medicinal materials in parts by weight:
3 to 750 parts of hawthorn, 3 to 600 parts of sea buckthorn, 6 to 450 parts of fragrant solomonseal rhizome, 4 to 450 parts of kudzuvine root, 8 to 525 parts of honeysuckle, 2 to 600 parts of dandelion, 3 to 450 parts of perilla, 5 to 750 parts of radish seed, 3 to 600 parts of dried ginger and 6 to 450 parts of chrysanthemum.
In another embodiment, the composition further comprises a pharmaceutically acceptable carrier.
The invention also provides a preparation method of the functional food granule for preventing and treating the three highs, which adopts the technical proposal that the preparation method comprises the following steps:
(1) weighing the medicinal materials according to the following weight ratio, and cleaning;
3 to 50 parts of hawthorn, 3 to 40 parts of sea buckthorn, 6 to 30 parts of fragrant solomonseal rhizome, 4 to 30 parts of kudzuvine root, 8 to 35 parts of honeysuckle, 2 to 40 parts of dandelion, 3 to 30 parts of perilla, 5 to 50 parts of radish seed, 3 to 40 parts of dried ginger and 6 to 30 parts of chrysanthemum;
(2) drying the medicinal materials, and grinding into powder;
(3) the medicinal material powder is fully mixed and then sterilized at high temperature;
(4) adding excipient, shaping and granulating to form granules;
(5) sterilizing at high temperature again.
The invention also provides a preparation method of the functional food paste for preventing and treating the three highs, which adopts the technical proposal that the preparation method comprises the following steps:
(1) weighing the medicinal materials according to the following weight ratio, cleaning, and concentrating, decocting, removing residues, and collecting concentrated juice;
45-750 parts of hawthorn, 45-600 parts of sea buckthorn, 30-450 parts of polygonatum, 50-450 parts of kudzuvine root, 20-525 parts of honeysuckle, 50-600 parts of dandelion, 30-450 parts of perilla, 20-750 parts of radish seed, 10-600 parts of dried ginger and 20-450 parts of chrysanthemum;
(2) adding 200-500 parts of isomaltooligosaccharide and 200-500 parts of maltitol, and melting to obtain the cream.
The invention also provides application of the food composition in preparing functional food for preventing and treating three-high symptoms.
The invention has the following technical effects:
the components of the invention are mutually carried, the bioavailability is high, and the invention can clear internal stagnation, such as phlegm, turbid urine, blood stasis, excessive heat and the like, open the running channel of the ventilator, increase the driving force and adjust the whole state of qi and blood running, thereby improving viscera functions.
The invention starts from two aspects of symptoms and root causes of the three-high symptoms, aims at the clinical indexes of the three-high symptoms to treat the symptoms on one hand, and comprehensively adjusts the human body by combining the forces of the medicines to achieve the aim of treating the root cause on the other hand. The raw materials in the formula adopt medicinal and edible plant medicines, so that not only can the three-high symptoms be prevented and treated, but also the intravascular garbage can be removed, the cell vitality can be enhanced, the purpose of health care can be achieved, and the health care concept of 'green health' is met.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention more clear, the technical solutions of the embodiments of the present invention are clearly and completely described below. It will be apparent that the described embodiments are some, but not all, embodiments of the invention. All other embodiments, which can be made by a person skilled in the art without creative efforts, based on the described embodiments of the present invention fall within the protection scope of the present invention. Unless otherwise defined, technical or scientific terms used herein should be given the ordinary meaning as understood by one of ordinary skill in the art to which this invention belongs.
The invention relates to a functional food composition for preventing and treating three-high symptoms, which is prepared from the following medicinal materials in parts by weight:
3 to 750 parts of hawthorn, 3 to 600 parts of sea buckthorn, 6 to 450 parts of fragrant solomonseal rhizome, 4 to 450 parts of kudzuvine root, 8 to 525 parts of honeysuckle, 2 to 600 parts of dandelion, 3 to 450 parts of perilla, 5 to 750 parts of radish seed, 3 to 600 parts of dried ginger and 6 to 450 parts of chrysanthemum.
Preferably, it further comprises a pharmaceutically acceptable carrier.
The efficacy of each component of the invention is as follows:
(1) Hawthorn (shanzha) Crataegi frames:
mature fruit of the rose family plant, mountain red Crataegus pinnatifida bge.var.major N.E.Br. or Crataegus pinnatifida bge.
The chemical components are as follows: fructus crataegi contains flavonoids, triterpene saponins (ursolic acid, oleanolic acid, crataegolic acid, etc.), saponin tannins, free acids, fatty acids, vitamin C, inorganic salts, and red pigment.
Pharmacological action: the fatty acid can promote fat digestion, increase secretion of gastric digestive enzyme to promote digestion, and has certain regulating effect on gastrointestinal function. The extract can dilate coronary artery, increase coronary flow, and protect myocardial ischemia and anoxia; and has effects in tonifying heart, lowering blood pressure, and relieving arrhythmia; also reducing blood lipid, anti-atherosclerosis, which lowers serum cholesterol and triglycerides, may be achieved by increasing the concentration of high density cholesterol and its subfractions in the serum, increasing cholesterol excretion. In addition, haw can resist platelet aggregation, resist oxidation, strengthen immunity, induce diuresis, calm, shrink uterus, inhibit bacteria, etc.
(2) Sea buckthorn (shaj i) Hippophae Fructus:
mature fruit of Hippophae rhamnoides L.
The chemical components are as follows: contains multiple physiologically active substances. Mainly comprises vitamins, isorhamnetin, proteins, carotene, amino acids, amides, flavonoids, apigenin, quercetin, kaempferol, beta-sitosterol, cryptoxanthin, saccharides, organic acids, steroic acids, fatty acids, lipids and microelements.
Pharmacological action: has effects in reducing blood lipid, relieving cough, and eliminating phlegm; can regulate digestion function and promote ulcer healing; can enhance immunity; an anti-tumor; improving cardiovascular system function; promoting hematopoiesis; reducing the viscosity of whole blood; inhibiting platelet aggregation; lowering serum total cholesterol, and increasing serum high density lipoprotein cholesterol and liver total cholesterol; inhibiting formation of experimental thrombus; protecting liver; anti-gastric ulcer; oxidation resistance; anti-inflammatory; increasing phagocytic function of reticuloendothelial system; antiallergic agent. The oleum Hippophae has certain effects of resisting tumor, depression and radiation. (Hua Xiyao journal 2020,35 (02): 211-217)
(3) Polygonatum odoratum (yuzhu) polygonatum odoratum (Polygonatum odoratum):
is rhizome of Druce. Of Polygonatum odoratum Polygonatum odoratum (Mill.) of Liliaceae.
The chemical components are as follows: the product contains steroid saponin (such as Convallaria majalis, and Convallaria majalis), flavone and its glycoside (such as elyseginoside), microelements, amino acid and other nitrogen-containing compounds, and also contains mucin, chelidonic acid, and vitamin A-like substance.
Pharmacological action: the product has effects of promoting antibody production of experimental animal, increasing phagocytic percentage and phagocytic index of macrophage, promoting interferon synthesis, inhibiting tubercle bacillus growth, reducing blood sugar, reducing blood lipid, relieving atherosclerosis plaque formation, dilating peripheral blood vessel and coronary artery, prolonging anoxia resisting time, strengthening heart, resisting oxidation, and resisting aging. Also has corticoid-like effects. The pharmacological action of Convallaria majaside in rhizome is the same as that of Convolvulus arvensis glycoside K, and has effects of tonifying heart, promoting urination, and tranquilizing.
(4) Radix Puerariae (gegen) Radix Puerariae (Radix Puerariae) ray Puerariae:
is the root of Pueraria lobata (Willd.) Ohwi of Leguminosae.
The chemical components are as follows: the product mainly contains flavonoid such as daidzin, daidzein, puerarin, etc., and also contains daidzein-4, 7-glucoside, puerarin-7-xyloside, puerarin, and isoflavone glycoside and starch.
Pharmacological action: pueraria decoction, alcoholic infusion, total flavonoids, daidzin and puerarin can be used for treating acute myocardial ischemia caused by posterior pituitrin. The radix Puerariae total flavone can dilate coronary blood vessel and cerebral blood vessel, increase coronary blood flow and cerebral blood flow, reduce myocardial oxygen consumption, and increase oxygen supply. The radix puerariae can directly dilate blood vessels, so that peripheral resistance is reduced, the blood pressure is obviously reduced, and the 'tightening' symptoms of patients with hypertension can be well relieved. Puerarin can improve microcirculation, increase local micro blood flow, and inhibit blood platelet aggregation. Pueraria has wide beta-receptor blocking effect. Has obvious spasmolytic effect on isolated intestinal canal of mice, and can resist intestinal canal spasm caused by acetylcholine. Pueraria lobata has also an obvious antipyretic effect. The oral puerarin can obviously reduce the blood sugar of the mice with the tetraoxypyrimidine hyperglycemia, reduce the content of serum cholesterol, strengthen the blood sugar reducing effect after selecting the compound formed by the puerarin with the lowest effective dose and the small (invalid) aspirin, can maintain for more than 24 hours, can obviously improve the sugar tolerance of the mice with the tetraoxypyrimidine hyperglycemia, obviously resist the blood sugar increasing effect of epinephrine, and is considered that the puerarin can be the main component of the puerarin for treating diabetes. The oral radix Puerariae decoction can be used for preventing the phenomenon of lowering of apoA-I in blood and increasing of cholesterol and triglyceride of drinking rats due to ethanol.
(5) Dandelion (pugongying) TaraxaciHerba:
the Asteraceae plant dandelion Taraxacum mongolicum hand-Mazz, taraxacum alkali T.sinicum Kitag, or dried whole herb of several plants of the same genus.
The chemical components are as follows: the product contains taraxasterol, taraxacin, inositol, lettuce alcohol, and taraxacum. Caffeic acid, resin, etc.
Pharmacological action: the decoction or infusion has strong inhibition effect on staphylococcus aureus, hemolytic streptococcus and catarrhal coccus, also has certain inhibition effect on pneumococcus, meningococcus, diphtheria bacillus, shigella flexneri, pseudomonas aeruginosa, leptospira and the like, and has synergism between TMP (sulfanilamide synergist). Has the functions of promoting the function of gallbladder, protecting liver, resisting endotoxin and promoting urination, and has more remarkable effect than the herba artemisiae capillaries decoction. The herba Taraxaci aerial part water extract can activate macrophage and has anti-tumor effect. In vitro experiments indicate that the product can excite the immune function of organisms. Clinical studies have reported that dandelions can be used for other diseases, such as: the dandelion decoction is used together with hawthorn, mistletoe, astragalus and shizandra berry for treating 37 cases of hyperlipidemia, 35 cases of which have good effects (new traditional Chinese medicine, 1988, 2:28) Zhao Xiu and the like, and the research proves that the dandelion decoction can reduce the blood sugar and blood fat level of diabetic mice, and is used together with potentilla flavone, so that the effects of reducing blood sugar and blood fat are better. (modern journal of Chinese and Western medicine combination 2021,30 (05): 563-567.)
(6) Honeysuckle (jinyinhua) LoniceraeJaponicae Flos:
is dried flower bud or flower with primary opening of lonicera japonica of Caprifoliaceae Lonicera japonica thunder, lonicera rubra L.hypoglauca Miq, lonicera japonica L.confusa DC, or lonicera macranthoides L.dasystyla red.
The chemical components are as follows: the product contains volatile oil, luteolin, inositol, flavonoids, inositol, saponin, tannin, etc. The separated chlorogenic acid and isochlorogenic acid are main components of the product for resisting bacteria.
Pharmacological action: the product has broad-spectrum antibacterial effect, and can inhibit pathogenic bacteria such as Staphylococcus aureus, bacillus dysenteriae, etc., and pathogenic microorganisms such as Leptospira, influenza virus, pathogenic mold, etc.; the flos Lonicerae decoction can promote phagocytosis of leukocyte: has obvious anti-inflammatory and antipyretic effects. The product has cholesterol reducing effect. The water and alcohol infusion has obvious cytotoxicity on sarcoma 180 and Ehrlich ascites tumor. In addition, a large amount of oral administration has a preventive effect on experimental gastric ulcer. Has certain excitation effect on central nerve. In experiments for researching the influence of honeysuckle on hyperglycemia mice, the honeysuckle extract has good effect of reducing the blood sugar of model mice with tetraoxypyrimidine and sucrose hyperglycemia. (journal of Chinese laboratory prescriptions, 2019,25 (04): 225-234)
(7) Perilla leaf (zisuye) Perillae Folium:
is leaf of Perilla Perilla frutescens (L.) Britt.
The chemical components are as follows: the product contains volatile oil, mainly perillaldehyde, L-limonene, and small amount of a-pinene.
Pharmacological action: the Perilla leaf decoction has mild antipyretic effect; has effects in promoting secretion of digestive juice and promoting gastrointestinal motility; can reduce bronchosecretion and relieve bronchospasm; the water decoction has inhibiting effect on colibacillus, dysentery bacillus and staphylococci. Perilla oil can shorten blood coagulation time, blood plasma calcium recovery time and thromboplastin time, and Perilla oil can raise blood sugar. Sun Anping the experiment proves that the perilla leaf polysaccharide can improve liver injury of rats with type II diabetes, can obviously reduce Fasting Blood Glucose (FBG), triglyceride (TG) and Total Cholesterol (TC) levels in the rats with type II diabetes, and has the effects of reducing blood glucose and blood lipid. (Chinese journal of Chinese medicine: 1-10[2023-01-12 ]) Perillae herba and its volatile oil have remarkable therapeutic effect in treating cardiovascular and cerebrovascular diseases, and high safety. Zhou Qinmei and the like systematically explore the vasodilation effect of the perilla leaf volatile oil and the active substances thereof, prove that the perilla leaf volatile oil has remarkable vasodilation effect on KCI pre-contracted isolated rat thoracic aortic annulus, and presumably the action mechanism is that the inflow of extracellular Ca2+ is reduced by influencing the opening of KCI-induced voltage-dependent calcium channels (VDCCs). The research shows that PAE has certain vasodilation effect. (journal of Chinese laboratory prescriptions, 2021,27 (13): 215-225.)
(8) Radish seed (laifuzi) Raphani segment:
is mature seed of Raphanus sativus L.
The chemical components are as follows: radish seed contains sulforaphane, sinapine, fatty oil (oil contains a large amount of erucic acid, linoleic acid and linolenic acid), beta-sitosterol, saccharides, various amino acids, vitamins and the like.
Pharmacological action: the radish seed extract has the advantages of mild and continuous antihypertensive effect, stable effect, strong repeatability and no obvious toxic or side effect; the blood pressure lowering effect of the injection is related to the drug concentration. Radish seed can enhance the rhythmic contraction of the ileum of an isolated rabbit and inhibit gastric emptying of a mouse. Has stronger antibacterial activity to various gram-positive bacteria and negative bacteria in vitro; the concentration of 1mg/ml of the sulforaphane can obviously inhibit staphylococcus and escherichia coli; the water extract (1:3) has various degrees of inhibition on 6 dermatophytes such as trichophyton concentricus in a test tube. Radish seed also has the functions of resisting bacteria, eliminating phlegm, relieving cough, relieving asthma, improving urination, reducing cholesterol, preventing arteriosclerosis, etc. Radish seeds can neutralize tetanus toxin and diphtheria toxin in vitro.
(9) Zingiber officinale (ganj iang) zingiberis rhizoma:
is dried rhizome of ginger Zingiber officinale Rosc.
The chemical components are as follows: the rhizoma Zingiberis contains about 2% of volatile oil, and contains zingiberene, phellandrene, embedded ethylene, jiang Xitong, gingerol, borneol, gingerol, citral, etc. Further comprises resin, starch, and multiple amino acids.
Pharmacological action: the stem Jiang Jinji can enhance the autonomous movement of the isolated heart. The rats were given an intravenous injection of dry Jiang Jinji 0.25.25 g/kg, which showed a transient pressure increasing and subsequent pressure decreasing effect and enhanced atrial autonomic activity. The zingiber officinale ether extract is 1.5ml/kg and 3.0ml/kg for gastric lavage, so that the oxygen consumption rate of the whole mice can be reduced, and the survival time of mice with normal-pressure closed hypoxia and KCN poisoning hypoxia models can be prolonged. The methanol extract of rhizoma Zingiberis recens has effects in reducing serum cholesterol, inhibiting increase of total cholesterol/phospholipid ratio in blood, and relieving atherosclerosis. The methanol or ether extract of rhizoma Zingiberis has tranquilizing, analgesic, antiinflammatory, and antiemetic effects; the water extract or the volatile oil can obviously prolong the experimental thrombosis time of the rats; the gingerol extract and gingerol and Jiang Laxi ketone contained therein have remarkable molluscicidal and anti-schistosome effects. The gingerol extract can obviously increase the bile secretion of rat liver and can be maintained for 3-4 hours.
(10) Chrysanthemum (juhua) Chrysanthemi Flos:
is a dry head flower of chrysanthemum Chrysanthemum morifolium Ramat.
The chemical components are as follows: the product contains volatile oil, which is borneol, camphor, chrysanthenone, etc., and also contains chrysantheside, adenine, choline, flavone, stachydrine, vitamin A, vitamin B1, vitamin E, amino acid, locust element, etc.
Pharmacological action: the chrysanthemum water soaking agent or decoction has certain antibacterial effect on staphylococcus aureus, various pathogenic bacilli and dermatophytes. The product also has inhibitory effect on influenza virus PR3 and leptospira. The flos Chrysanthemi preparation has effects of dilating coronary artery, increasing coronary blood flow, increasing myocardial oxygen consumption, lowering blood pressure, shortening clotting time, relieving fever, relieving inflammation, and tranquilizing. Experiments of chrysanthemum extract on the influence of blood fat of rats fed with high-fat feed show that the extract has obvious improvement effect on the rise of serum cholesterol of rats. The flos Chrysanthemi extract can reduce blood sugar of diabetic mice. The chrysanthemum total flavone can improve the morbidity symptoms of diabetic mice, promote the growth of the quality of the mice, and obviously reduce the blood glucose level and the glucose tolerance level. (Chinese herbal medicine, 2019,50 (19): 4785-4795.)
From a pharmacological point of view: (1) the pharmacological actions of the medicines on three highs mainly reduce and take account of bidirectional regulation. (2) All the medicines have pharmacological support for improving the functions of the cardiovascular system. (3) Some herbs in the recipe can enhance the immune system. (4) The several Chinese medicinal materials in the recipe have the functions of resisting bacteria and diminishing inflammation. (5) The whole prescription has better conditioning effect on people with easy irritability or unstable emotion.
From a traditional medical point of view: the medicine disclosed by the invention fully covers pathological factors such as blood stasis, turbid phlegm, food stagnation, accumulated heat and the like which are generated in a human body, has the effects of resolving stagnation, removing stagnation, resolving carbuncles, detoxifying, regulating urination and defecation, calming intestines and stomach, promoting blood circulation and the like, ensures that pathogenic factors have a way and five viscera are safe, can treat the existing uncomfortable symptoms, and can also play a role in treating the disease. It is particularly worth pointing out that the purple perilla and the kudzuvine root in the recipe both have the efficacy of detoxification, especially detoxification caused by food. Pueraria root can dispel various toxins, especially alcohol toxicity, and Perillae herba can dispel fish and crab toxicity and treat dog and snake bite. To cope with the dietary safety problem of the society today, it is necessary to add these two drugs. To date, perilla leaves are consumed in large quantities in northeast and japan to cover foods, especially raw foods.
The qi and blood flow of the human body is circulation, and the qi and blood flow is ascending and descending. Through lifting, the important nodes in the lifting device are communicated. The qi and blood circulation is blocked, and the circulation of qi and blood is stabilized by the promotion and actuation of the drug efficacy. The four herbs of Pueraria lobata, radish seed, perillae herba and Chrysanthemum in the present invention are all used when they act on qi and blood. The qi movement of the middle warmer is to promote the movement of the Chinese medicinal materials (radix Puerariae, perillae herba, and Raphani semen); the blood circulation promoting (chrysanthemum) and the wind removing (chrysanthemum) are open roads; the heart meridian (Perilla herb) and the striae and sweat pores (Pueraria lobata) are the passages for opening the upper energizer and guiding upward. The function of the kudzuvine root of opening striae is not negligible, and the formula of the auxiliary row is cloud: the lung bitter qi flowing upwards and being pungent and easy to eat and dissipate, the striae and sweat pores being opened to ventilate are said to come from the decoction menstruation method. "jin Kui Yao Chart: the striae and striae are the true points of the three-jiao, the points of qi and blood, and the texture of the viscera. "
The invention relates to a preparation method of functional food granules for preventing and treating three highs, which comprises the following steps:
1. weighing the medicinal materials according to the weight ratio, and cleaning;
2. drying the medicinal materials, and grinding into powder;
3. the medicinal material powder is fully mixed and then sterilized at high temperature;
4. adding excipient, shaping and granulating to form fine particles;
5. sterilizing at high temperature again.
The invention relates to a preparation method of a functional food paste for preventing and treating three highs, which comprises the following steps:
1. weighing the medicinal materials according to the weight ratio, cleaning, and concentrating, decocting, removing residues, and collecting concentrated juice;
2. adding 13-500 parts of isomaltooligosaccharide and 13-500 parts of maltitol, and melting to obtain the cream.
Example 1
A functional food granule for preventing and treating three highs is prepared from the following raw materials:
3 parts of hawthorn, 3 parts of sea buckthorn, 6 parts of fragrant solomonseal rhizome, 4 parts of kudzuvine root, 8 parts of honeysuckle, 2 parts of dandelion, 3 parts of perilla, 5 parts of radish seed, 3 parts of dried ginger and 6 parts of chrysanthemum.
The preparation method comprises the following steps:
1. weighing the medicinal materials according to the weight ratio, and cleaning;
2. drying the medicinal materials, and grinding into powder;
3. fully mixing the medicinal material powder, and sterilizing at a high temperature of above 100deg.C;
4. adding excipient, shaping and granulating to form fine particles;
5. and sterilizing at high temperature above 100deg.C.
Example 2
A functional food granule for preventing and treating three highs is prepared from the following raw materials:
5 parts of hawthorn, 5 parts of sea buckthorn, 10 parts of fragrant solomonseal rhizome, 6 parts of kudzuvine root, 13 parts of honeysuckle, 3 parts of dandelion, 5 parts of perilla, 8 parts of radish seed, 5 parts of dried ginger and 10 parts of chrysanthemum.
The preparation method comprises the following steps:
1. weighing the medicinal materials according to the weight ratio, and cleaning;
2. drying the medicinal materials, and grinding into powder;
3. fully mixing the medicinal material powder, and sterilizing at a high temperature of above 100deg.C;
4. adding excipient, shaping and granulating to form fine particles;
5. and sterilizing at high temperature above 100deg.C.
Example 3
A functional food granule for preventing and treating three highs is prepared from the following raw materials:
50 parts of hawthorn, 50 parts of sea buckthorn, 100 parts of fragrant solomonseal rhizome, 66 parts of kudzuvine root, 133 parts of honeysuckle, 33 parts of dandelion, 50 parts of perilla, 83 parts of radish seed, 50 parts of dried ginger and 100 parts of chrysanthemum.
The preparation method comprises the following steps:
1. weighing the medicinal materials according to the weight ratio, and cleaning;
2. drying the medicinal materials, and grinding into powder;
3. fully mixing the medicinal material powder, and sterilizing at a high temperature of above 100deg.C;
4. adding excipient, shaping and granulating to form fine particles;
5. and sterilizing at high temperature above 100deg.C.
Example 4
A functional food paste for preventing and treating three highs is prepared from the following raw materials:
45 parts of hawthorn, 45 parts of sea buckthorn, 30 parts of fragrant solomonseal rhizome, 50 parts of kudzuvine root, 20 parts of honeysuckle, 50 parts of dandelion, 30 parts of perilla, 20 parts of radish seed, 10 parts of dried ginger and 20 parts of chrysanthemum.
The preparation method comprises the following steps:
1. weighing the medicinal materials according to the weight ratio, cleaning, and concentrating, decocting, removing residues, and collecting concentrated juice;
2. adding 200 parts of isomaltooligosaccharide and 200 parts of maltitol, and melting and collecting paste.
Example 5
A functional food paste for preventing and treating three highs is prepared from the following raw materials:
50 parts of hawthorn, 20 parts of sea buckthorn, 30 parts of fragrant solomonseal rhizome, 50 parts of kudzuvine root, 20 parts of honeysuckle, 50 parts of dandelion, 30 parts of perilla, 20 parts of radish seed, 10 parts of dried ginger and 20 parts of chrysanthemum.
The preparation method comprises the following steps:
1. weighing the medicinal materials according to the weight ratio, adding 8 times of water after cleaning, decocting for 1 hour, removing residues, and taking thick juice;
2. adding 200 parts of isomaltooligosaccharide and 200 parts of maltitol, and melting and collecting paste.
Example 6
A functional food paste for preventing and treating three highs is prepared from the following raw materials:
750 parts of hawthorn, 600 parts of sea buckthorn, 450 parts of fragrant solomonseal rhizome, 450 parts of kudzuvine root, 525 parts of honeysuckle, 600 parts of dandelion, 450 parts of perilla, 750 parts of radish seed, 600 parts of dried ginger and 450 parts of chrysanthemum.
The preparation method comprises the following steps:
1. weighing the medicinal materials according to the weight ratio, adding 6 times of water after cleaning, decocting for 1 hour, removing residues, and taking thick juice;
2. adding 500 parts of isomaltooligosaccharide and 500 parts of maltitol, and melting to obtain the cream.
Comparative example 1
In the comparative example, on the basis of the example 1, the medicine of kudzuvine root is not used, and the preparation method is the same as that of the example 1.
Comparative example 2
In this comparative example, on the basis of example 1, the preparation method of the same as that of example 1 was carried out by using less perilla herb.
Comparative example 3
The comparative example is based on the example 1, the radish seed is used less as a medicament, and the preparation method is the same as that of the example 1.
Comparative example 4
The comparative example is based on example 4, and the preparation method of the comparative example is the same as that of example 4, except that the chrysanthemum is used as the drug.
Comparative example 5
The comparative example is based on the example 4, three medicines of kudzuvine root, purple perilla and radish seed are used less, and the preparation method is the same as that of the example 4.
Comparative example 6
The comparative example is based on the example 4, and four medicines of kudzuvine root, radish seed, purple perilla and chrysanthemum are used less, and the preparation method is the same as that of the example 4.
The effect test of the invention is as follows:
6 patients with hyperlipidemia, 6 patients with hypertension and 12 patients with hyperglycemia are divided into 12 observation groups and 12 control groups (3 patients with hyperlipidemia, 3 patients with hypertension and 6 patients with hyperglycemia respectively).
The observation group 12 persons were divided into six groups, and the granule preparation or the paste preparation of examples 1 to 6 was taken for 21 days, and the health condition of the 12 persons was examined, and the examination results are shown in table 1.
TABLE 1
Detection result: the blood lipid index, blood pressure index and blood glucose index corresponding to each disease patient are obviously reduced, wherein the average reduction rate of the patients with hyperlipidemia is 18.8%, the average reduction rate of the patients with hypertension is 6.3%, and the average reduction rate of the patients with hyperglycemia is 9.6%. During the administration period, some patients have symptoms such as tinnitus, dizziness and the like, obviously improve symptoms of gastrointestinal tract, such as constipation, abdominal distension and other uncomfortable symptoms, and have light self-sense body and good spirit after administration, and have no adverse reaction. The invention has obvious curative effect and small side effect on the three-high disease.
The control group of 12 persons was divided into six groups, and the granule preparation or the paste preparation of comparative examples 1 to 6 was taken respectively, and the health condition of the 12 persons was examined after 21 days of taking, and the examination results are shown in Table 2.
TABLE 2
Detection result: the blood pressure index, the blood fat index and the blood sugar index corresponding to patients with various diseases are not obviously reduced.
The foregoing has shown and described the basic principles and main features of the present invention and the advantages of the present invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, and that the above embodiments and descriptions are merely illustrative of the principles of the present invention, and various changes and modifications may be made without departing from the spirit and scope of the invention, which is defined in the appended claims. The scope of the invention is defined by the appended claims and equivalents thereof.

Claims (5)

1. The functional food composition for preventing and treating the three-high disease is characterized by being prepared from the following medicinal materials in parts by weight:
3 to 750 parts of hawthorn, 3 to 600 parts of sea buckthorn, 6 to 450 parts of fragrant solomonseal rhizome, 4 to 450 parts of kudzuvine root, 8 to 525 parts of honeysuckle, 2 to 600 parts of dandelion, 3 to 450 parts of perilla, 5 to 750 parts of radish seed, 3 to 600 parts of dried ginger and 6 to 450 parts of chrysanthemum.
2. The functional food composition for preventing and treating hyperlipidemia according to claim 1, wherein the composition further comprises a pharmaceutically acceptable carrier.
3. The preparation method of the functional food granule for preventing and treating the three highs is characterized by comprising the following steps of:
(1) weighing the medicinal materials according to the following weight ratio, and cleaning;
3 to 50 parts of hawthorn, 3 to 40 parts of sea buckthorn, 6 to 30 parts of fragrant solomonseal rhizome, 4 to 30 parts of kudzuvine root, 8 to 35 parts of honeysuckle, 2 to 40 parts of dandelion, 3 to 30 parts of perilla, 5 to 50 parts of radish seed, 3 to 40 parts of dried ginger and 6 to 30 parts of chrysanthemum;
(2) drying the medicinal materials, and grinding into powder;
(3) the medicinal material powder is fully mixed and then sterilized at high temperature;
(4) adding excipient, shaping and granulating to form granules;
(5) sterilizing at high temperature again.
4. The preparation method of the functional food paste for preventing and treating the three highs is characterized by comprising the following steps of:
(1) weighing the medicinal materials according to the following weight ratio, cleaning, and concentrating, decocting, removing residues, and collecting concentrated juice;
45-750 parts of hawthorn, 45-600 parts of sea buckthorn, 30-450 parts of polygonatum, 50-450 parts of kudzuvine root, 20-525 parts of honeysuckle, 50-600 parts of dandelion, 30-450 parts of perilla, 20-750 parts of radish seed, 10-600 parts of dried ginger and 20-450 parts of chrysanthemum;
(2) adding 200-500 parts of isomaltooligosaccharide and 200-500 parts of maltitol, and melting to obtain the cream.
5. Use of a food composition according to any one of claims 1-2 for the preparation of a functional food for the prevention and treatment of hyperlipidemia.
CN202311413503.7A 2023-10-30 2023-10-30 Functional food composition for preventing and treating three-high symptoms and preparation method thereof Pending CN117356707A (en)

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Application Number Priority Date Filing Date Title
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