CN117338669A - Oil control composition, preparation method and application thereof - Google Patents
Oil control composition, preparation method and application thereof Download PDFInfo
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- CN117338669A CN117338669A CN202311551603.6A CN202311551603A CN117338669A CN 117338669 A CN117338669 A CN 117338669A CN 202311551603 A CN202311551603 A CN 202311551603A CN 117338669 A CN117338669 A CN 117338669A
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- Prior art keywords
- extract
- parts
- oil
- alpine
- leontopodium
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
- A61Q1/02—Preparations containing skin colorants, e.g. pigments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Botany (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Cosmetics (AREA)
Abstract
The invention provides an oil control composition, a preparation method and application thereof. The composition comprises the composition comprising an extract from coastal cress, an extract from sunflower seeds, an extract from alpine leontopodium herb and an extract from saussurea involucrata. The cosmetic product containing the composition has excellent oil control, moisturizing and soothing and repairing effects.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to an oil control composition, a preparation method and application thereof.
Background
Oily skin is produced by the vigorous secretion of sebaceous glands in humans, and the nature of sebaceous glands in skin is determined by genetic factors. Skin can be classified roughly clinically according to the amount of lipid on the skin surface: oily skin, dry skin, neutral skin, mixed skin, and the like. The oily skin has the advantages that the secretion function of sebaceous glands is more vigorous, the face is oily, the skin is not easy to clean, and the beautiful oily light is affected; and is also prone to facial skin disorders such as acne. Seborrheic dermatitis, and the like. Controlling excessive secretion of sebaceous glands and alleviating oily symptoms is a key to maintaining skin health.
Compared with the traditional chemical oil control substances, the plant oil control substances have the advantages of being safer and milder, are popular with consumers, have the trend of gradually replacing the chemical oil control substances, are the tea tree essential oil, the hawthorn extract, the plant starch and the like, but due to the complexity of the plant raw materials, related researches are still in the continuous development and exploration stages. Besides the efficacy of a single plant, the method has wide prospect on how to select and match multiple plant raw materials to better exert the efficacy of each raw material.
In view of the above, there remains a need in the art for multi-plant oil control products having excellent oil control.
Disclosure of Invention
In order to solve the above problems, in a first aspect, the present invention aims to provide a composition comprising an extract from coastal cress, an extract from sunflower seeds, an extract from alpine lewisa and an extract from saussurea involucrata.
In a specific embodiment, the extract from coastal cress in the composition of the invention is a coastal cress extract or a coastal cress callus culture filtrate; the extract from the alpine leontopodium herb is a alpine leontopodium herb flower/leaf extract, an alpine leontopodium herb extract or an alpine leontopodium herb callus extract; the extract from saussurea involucrata is saussurea involucrata extract or saussurea involucrata cell culture; and/or the extract from sunflower seed is sunflower seed, sunflower seed oil, sunflower seed extract or sunflower seed oil unsaponifiable.
In a specific embodiment, the composition of the invention comprises the following components by weight:
3-15 parts (e.g. 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts) of extract from seashore parsley, 8-12 parts (e.g. 9 parts, 10 parts, 11 parts) of extract from sunflower seeds, 1-5 parts (e.g. 2 parts, 3 parts, 4 parts) of extract from alpine leontopodium herb and 4-9 parts (e.g. 5 parts, 6 parts, 7 parts, 8 parts) of extract from saussurea involucrata.
For example, the composition of the invention comprises by weight 10 parts of the extract from coastal cress, 9 parts of the extract from sunflower seeds, 1 part of the extract from alpine leontopodium herb and 5 parts of the extract from saussurea involucrata; 8 parts of the extract from coastal cress, 11 parts of the extract from sunflower seeds, 2 parts of the extract from alpine leontopodium herb and 6 parts of the extract from saussurea involucrata; alternatively, 5 parts of the extract from seashore parsley, 8 parts of the extract from sunflower seeds, 4 parts of the extract from alpine leontopodium herb and 8 parts of the extract from saussurea involucrata.
In a preferred embodiment, the composition of the invention comprises the following components by weight:
6-9 parts of an extract from coastal cress, 10 parts of an extract from sunflower seeds, 3 parts of an extract from alpine leontopodium herb and 6-8 parts of an extract from saussurea involucrata.
In a more preferred embodiment, the composition of the invention comprises the following components by weight:
3 parts of the extract from coastal cress, 10 parts of the extract from sunflower seeds, 3 parts of the extract from alpine leontopodium herb and 6 parts of the extract from saussurea involucrata.
In a specific embodiment, the composition of the invention further comprises caprylic/capric triglyceride and/or lecithin. In a preferred embodiment, the lecithin is soy lecithin or hydrogenated lecithin.
In particular embodiments, the compositions of the present invention may also comprise 20-45 parts by weight of the caprylic/capric triglyceride and/or 8-18 parts by weight of the lecithin. In preferred embodiments, the composition of the present invention may further comprise 25-40 parts by weight of the caprylic/capric triglyceride and/or 10-16 parts by weight of the lecithin. In a more preferred embodiment, the composition of the present invention may further comprise 30-35 parts by weight of the caprylic/capric triglyceride and/or 12-14 parts by weight of the lecithin.
In further specific embodiments, the composition of the invention comprises 3 parts of said extract from coastal cress, 10 parts of said extract from sunflower seeds, 3 parts of said extract from alpine leontopodium herb, 6 parts of said extract from saussurea involucrata, 20 parts of said caprylic/capric triglyceride and 8 parts of said lecithin.
In a second aspect, the object of the present invention is to provide a process for the preparation of a composition as described in the first aspect, comprising dissolving lecithin in caprylic/capric triglyceride to obtain a mixture; respectively dissolving the coastal cress extract, the extract from the alpine leontopodium herb and the extract from the saussurea involucrata in the mixture to obtain a coastal cress oil-soluble raw material, an alpine leontopodium herb oil-soluble raw material and a saussurea involucrata oil-soluble raw material; and adding said extract from sunflower seeds.
In a specific embodiment, the preparation method of the present invention comprises the steps of:
(1) Measuring lecithin to be dissolved in caprylic/capric triglyceride to obtain the mixture;
(2) Respectively measuring the extract from coastal cress, the extract from alpine leontopodium herb and the extract from snow lotus herb, and respectively dissolving the extracts in the mixture prepared in the step (1) to obtain the coastal cress oil-soluble raw materials, the alpine leontopodium herb oil-soluble raw materials and the snow lotus herb oil-soluble raw materials;
(3) Measuring and uniformly mixing the coastal cress oil-soluble raw material, the alpine leontopodium oil-soluble raw material and the saussurea involucrata oil-soluble raw material in the step (2) to obtain an oil-soluble raw material mixture, and then adding the extract from sunflower seeds into the oil-soluble raw material mixture to obtain the composition.
In a preferred embodiment, the weight ratio of said lecithin to said caprylic/capric triglyceride in said preparation method of the present invention is 2:5. in a more preferred embodiment, the lecithin in the preparation method of the present invention is soybean lecithin or hydrogenated lecithin.
In a third aspect, the present invention aims to provide a cosmetic product comprising a composition according to the first aspect.
In particular embodiments, the products of the present invention may further comprise emollients and fillers. In optional embodiments, the product of the present invention may further comprise a colorant.
In particular embodiments, the product of the invention may be a cleaning-type product, a care-type product or a make-up/finishing-type product.
For example, the product of the present invention may be a skin cleansing product such as a facial cleanser, cleansing oil, or the like; can be skin care products such as skin lotions, creams, essences, masks, etc.; can be cosmetic products such as foundation solution, honey powder, sun-proof liquid, etc.
The beneficial effects are that:
compared with the prior art, the composition of the invention and the cosmetic product using the same have the following advantages:
(1) The oil control composition provided by the invention is based on research and exploration of the oil control effect of the coastal cress by the inventor, four plant raw materials of the extract from the coastal cress, the extract from sunflower seeds, the extract from the alpine leontopodium herb and the extract from the saussurea involucrata are selected, and the oil control composition with the synergistic oil control effect is obtained.
(2) The composition is oil-soluble, has the effects of moisturizing, relieving and repairing skin, and particularly has more remarkable effect on oily skin.
(3) The composition can protect and strengthen skin barrier, resist oxidation, inhibit lipid synthesis, relieve, and improve oil-sensitive skin.
(4) The composition of the present invention has no acne-causing property and does not cause extra burden to the skin.
(5) The composition of the present invention can be applied to various makeup cosmetics in addition to the care cosmetics.
Drawings
FIG. 1 is a fluorescent image of an oil control assay of composition 1 of the present invention.
FIG. 2 is a fluorescence plot of a soothing zebra fish test of composition 1 of the present invention.
FIG. 3 shows the results of the measurement of the level of tryptase expression in the composition 1 of the present invention.
Fig. 4 is a graph showing the results of the moisture-retaining efficacy test of the zebra fish of the present invention composition 1.
FIG. 5 is a fluorescent image of an oil control assay of composition 2 of the present invention.
FIG. 6 is a fluorescent image of an oil control assay of composition 3 of the present invention.
FIG. 7 is a fluorescent image of comparative composition 1 oil control assay.
FIG. 8 is a fluorescent plot of comparative composition 2 oil control detection experiments.
Detailed Description
In the present invention, the inventors have unexpectedly found that a composition having remarkable oil control, moisturizing, soothing effects can be obtained by combining the active ingredients from among the coastal cress, alpine leontopodium herb, snow lotus herb and sunflower seed.
Definition of the definition
Coastal cress (Eryngium maritimum), also known as Haidongqing, is useful as an herbal medicine for the treatment of various diseases, and research on its chemical composition has recently found its secondary metabolite having various specific structures and functions, and started to be applied to the cosmetic field. The person skilled in the art will be aware of the "extract from coastal cress" in the present invention means a substance containing coastal cress active ingredient obtained from coastal cress (e.g. organs, calli etc.) as raw material, including but not limited to coastal cress extract (ERYNGIUM MARITIMUM EXTRACT) and coastal cress calli culture filtrate (ERYNGIUM MARITIMUM CALLUS CULTURE FILTRATE) already listed in the used cosmetic raw materials catalog, and raw materials containing coastal cress active ingredient which will be listed in the used cosmetic raw materials catalog in the future. Illustratively, the coastal parsley callus culture filtrate is prepared by: solid callus is induced by selecting coastal cress explants, high-quality cells are selected for carrying out virtual floating culture to obtain plant cell virtual floating culture solution, and the plant cell virtual floating culture solution is dried and crushed to obtain raw materials.
The alpine leontopodium herb (Leontopodium alpinum) contains various substances with antioxidant, anti-inflammatory and cytoprotective effects, such as tannin, flavonoid, chlorogenic acid, phytosterol and the like, and has wide application prospect in the field of cosmetics. Those skilled in the art will appreciate that "EXTRACT from alpine leontopodium" in the present invention means a material containing active ingredients of alpine leontopodium obtained from alpine leontopodium (e.g., organs, calli, etc.) as a raw material, and includes, but is not limited to, alpine leontopodium flower/LEAF EXTRACT (LEONTOPODIUM ALPINUM FLOWER/LEAF EXTRACT), alpine leontopodium EXTRACT (LEONTOPODIUM ALPINUM EXTRACT) and alpine leontopodium calli EXTRACT (LEONTOPODIUM ALPINUM CALLUS CULTURE EXTRACT) already listed in the "used cosmetics raw materials catalog", and raw materials containing active ingredients of alpine leontopodium which will be listed in the "used cosmetics raw materials catalog" in the future. Illustratively, the method for preparing the alpine leontopodium herb callus extract comprises the following steps: solid callus is induced by selecting high mountain leontopodium herb explants, high-quality cells are selected for carrying out virtual floating culture to obtain plant cell virtual floating culture solution, and the plant cell virtual floating culture solution is dried and crushed to obtain the raw material.
The snow lotus herb (Saussurea involucrata) can be used as a whole herb, and researches on chemical components of the snow lotus herb show that the snow lotus herb contains various active substances such as protein, amino acid, flavonoid compounds, alkaloids and the like, and has various skin care effects such as antioxidation, whitening and the like. Those skilled in the art will appreciate that "extract from herba Saussureae Involueratae" in the present invention refers to a material containing effective components of herba Saussureae Involueratae obtained from herba Saussureae Involueratae (e.g., organs, calli, etc.), including but not limited to cell cultures of saussurea involucrata, extracts of herba Saussureae Involueratae (saussurea involucrata extract) already listed in the catalog of cosmetic materials used, and materials containing effective components of herba Saussureae Involueratae that will be listed in the catalog of cosmetic materials used in the future. Illustratively, the preparation method of the snow lotus herb extract comprises the following steps: solid callus is induced by selecting snow lotus explant, high-quality cells are selected for carrying out virtual floating culture to obtain plant cell virtual floating culture solution, and the plant cell virtual floating culture solution is dried and crushed to obtain raw materials.
Sunflower (Helianthus annuus L) seeds, i.e. sunflower seeds, contain various antioxidant, whitening and anti-aging active substances, such as zinc element, vitamin E, phenolic acid, etc. The person skilled in the art will be aware of "EXTRACT from SUNFLOWER SEEDs" in the present invention means a substance containing SUNFLOWER SEEDs as an active ingredient obtained from SUNFLOWER SEEDs, including but not limited to SUNFLOWER SEEDs (HELIANTHUS ANNUUS (sunlower) SEED), SUNFLOWER SEED OIL (HELIANTHUS ANNUUS (sunlower) SEED OIL), SUNFLOWER SEED EXTRACT (HELIANTHUS ANNUUS (sunlower SEED EXTRACT), SUNFLOWER SEED OIL unsaponifiable matter (HELIANTHUS ANNUUS (sunlower) SEED OIL UNSAPONIFIABLES) as well as raw materials containing SUNFLOWER SEEDs as listed in the catalogue of used cosmetic raw materials in the future.
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention, and it is apparent that the described embodiments are some embodiments of the present invention, but not all embodiments of the present invention.
All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
The technical scheme of the invention is further described below by the specific embodiments with reference to the accompanying drawings.
Example 1: preparation and efficacy detection of composition 1 of the present invention
Preparation of composition 1 according to the invention
(1) Weighing 30g of herba Lespedezae Cuneatae callus extract (supplier: croda International Plc), 30g of herba Saussureae Involueratae extract (supplier: lian Purui Biotech Co., ltd.), 30g of herba Lespedezae Cuneatae callus culture filtrate (supplier: SEPPIC group flag company Biotec Marine);
(2) Weighing 20g of soybean lecithin, dissolving in 50g of caprylic/capric triglyceride, and preparing 3 parts of mixture;
(3) Dissolving the coastal cress callus culture filtrate, the alpine leontopodium herb callus extract and the saussurea involucrata extract which are measured in the step (1) in 3 parts of the mixture prepared in the step (2) respectively, and fully dissolving the raw materials to obtain the coastal cress oil-soluble raw materials, the alpine leontopodium herb oil-soluble raw materials and the saussurea involucrata oil-soluble raw materials respectively;
(4) Measuring and taking 20g of the coastal cress oil-soluble raw materials, 20g of the alpine leontopodium oil-soluble raw materials and 40g of the saussurea involucrata oil-soluble raw materials in the step (3), uniformly mixing to obtain an oil-soluble raw material mixture, and adding 20g of sunflower seed oil unsaponifiable matters into the oil-soluble raw material mixture to obtain the composition.
The extracts used in the other examples and comparative examples below were the same as those in this example.
The ratio of the amount of each raw material in the oil control composition provided in this example is shown in the following table:
oil control efficacy detection
The principle of the oil control detection method is as follows: sebaceous glands are the source and target tissues of androgens, in which dehydroepiandrosterone is produced, which are converted, catalyzed by a series of enzymes, to the most active testosterone and 5α -dihydrotestosterone, which stimulate the synthesis of lipids and the proliferation and differentiation of sebaceous gland cells. In this proliferation and differentiation process, undifferentiated naive cells first proliferate, and part of the daughter cells form lipid droplets and move toward the center of glandular cells, gradually developing and differentiating into mature sebaceous gland cells capable of accumulating and secreting lipids. The detection is provided with a model control group (the culture medium contains testosterone to stimulate the proliferation of sebaceous gland cells and the secretion of grease) and a sample group (the culture medium contains testosterone and the composition of the invention with different concentrations), and the quantity of grease secreted by the sebaceous gland cells of each group is detected by a nile red staining method, so that whether the sample has the oil control effect is judged.
The experimental steps are as follows:
(1) Sebaceous gland cell inoculation into six-well plate (3×10) 5 Personal/well), sebaceous gland cell culture medium (available from Guangdong Boxi biological Co., ltd.) at 37℃with 5% CO 2 Incubation was carried out for 24 hours.
(2) After incubation, the model control group is replaced by a culture medium containing testosterone (i.e. 100mM testosterone is added into sebaceous gland cell culture medium), the sample group is replaced by a culture medium containing sample with corresponding concentration and testosterone (i.e. corresponding concentration of sample and 100mM testosterone is added into sebaceous gland cell culture medium), 37 ℃ and 5% CO 2 Incubation was carried out for 24 hours.
(3) After incubation, the medium was removed, pre-chilled DHanks was washed 3 times, fixed with 60% isopropyl alcohol, nile red stained after D-Manks washing, photographed with a fluorescence microscope, and Image J software analyzed the fluorescence intensity of each group and calculated using the following disclosure:
wherein A is fluorescence intensity.
(3) The sample preparation method comprises the following steps: firstly, weighing a certain amount of composition samples, diluting the composition samples into stock solution with the concentration of 20% by using DMSO (dimethyl sulfoxide), and then, diluting the stock solution into the required concentration by using a cell culture medium.
The test results are shown in the following table:
the detection result shows that the fluorescence intensity of the sample in the sample group is obviously reduced compared with that in the model control group, and the sample has obvious oil control effect.
Test for soothing zebra fish
Principle of: sodium dodecyl sulfonate (SLS) may trigger a stimulating reaction in the body after acting on the body, and the irritant enters the zebra fish body to induce inflammatory reaction, neutrophil cells generate immune response, migrate to the skin epidermis and aggregate. The change of the quantity of the skin neutrophils before and after the treatment of the transgenic neutrophil green fluorescent strain zebra fish (MPX) is utilized to detect whether the sample has the relieving effect. Neutrophils from zebra fish embryos and human neutrophils are highly similar in morphology, biochemistry and physiological function. Neutrophils are the first leukocytes to appear at the site of injury or pathogen invasion and act to clear infection or harmful substances. The test is carried out by using a model of inducing the damage of the nerve hillock cells in the fish embryo side line area to cause the aggregation of the neutrophils, the quantity change of the neutrophils in the fish embryo side line area of the test object treatment group and the model control group is compared, and the neutrophil inhibition rate is calculated to evaluate the relieving efficacy of the raw materials, the formula or the products.
Test system: transgenic neutrophils green fluorescent zebra fish (MPX).
Zebra fish age: 2 days post fertilization (2 dpf).
Sample size per set of experiments: 15 tails (n=10).
The adult fish raising and breeding method comprises the following steps: the adult fish breeding and reproducing method meets the requirements of international AAALAC authentication (authentication number: 001458).
The experimental steps are as follows:
1. zebra fish were randomly selected in 6-well plates with 15 tails per well.
2. The water-soluble administration of SLS establishes a zebra fish skin inflammation model.
3. Samples were given water-soluble, with normal and model controls set at 3mL per well.
Incubate at 4.28℃for 18h in the absence of light.
5. 10 zebra fish were randomly selected from each experimental group, photographed under a fluorescence microscope (see fig. 2 for partial results), analyzed by advanced image processing software and data were collected, the number of neutrophils on the skin of zebra fish (N) was analyzed, the soothing efficacy of the sample was calculated according to the following formula, and whether it had the soothing efficacy was judged. Calculating the relief efficacy:
the detection results are as follows:
| detecting items | Concentration of detection (%) | Efficacy (%) | Pi value | Detection result |
| Relieving effect | 0.1 | 56 | <0.001 | Statistically significant |
The detection result shows that the number of the zebra fish neutrophils in the sample of the sample group is obviously reduced compared with that of the model control group, and the sample has obvious anti-inflammatory and relieving effects.
Trypsin expression level assay
Principle of: tryptase (Tryptase) is a pre-synthesized neutral protease in mast cells and is an important indicator for clinical examination of allergic reactions. Zebra fish are allergic and also induce mast cells to secrete tryptase, which complexes with BAPNA substrates with a maximum absorbance peak at 405 nm. And detecting the relative absorbance value (OD 405 value) of the whole tryptase expression level of the zebra fish by using an enzyme-labeled instrument, and evaluating whether the sample has the relieving effect according to the tryptase expression level.
Test system: wild type AB strain.
Zebra fish age: 2 days post fertilization (2 dpf).
Sample size per set of experiments: 10 tails (three biological replicates, n=3).
The adult fish raising and breeding method comprises the following steps: meets the requirements of international AAALAC authentication (authentication number: 001458).
The experimental steps are as follows:
1. zebra fish were randomly selected in 12-well plates with 10 tails per well.
2. 2, 4-Dinitrochlorobenzene (DNCB) is added in water to establish a zebra fish allergy model.
3. Samples were given water-soluble, and normal control and model control were set simultaneously with a 1mL per well capacity. Three biological replicates.
4. Each experimental group was incubated with BAPNA at 28℃for 24h under light protection.
5. The OD value (tryptase content) of each experimental group of zebra fish at 405nm is detected by an enzyme-labeled instrument, the trypsin expression level (T) of the zebra fish is calculated, and whether the sample has the relieving effect is calculated and judged according to the following formula.
The test results (see fig. 3) showed that the tryptase expression level of the sample group was significantly reduced compared to the model control group, indicating that the sample had significant antiallergic soothing efficacy.
Zebra fish moisturizing efficacy detection
Principle of: the skin surface of zebra fish treated with sodium chloride will shrink due to water loss caused by osmotic pressure, the tail area will be reduced due to shrinkage, and the moisturizing effect of cosmetics will be evaluated by the effect on the tail area.
Test system: mutant melanin alleles zebra fish (Albino).
Zebra fish age: 2 days post fertilization (2 dpf).
Sample size per set of experiments: 15 tails (n=10).
The adult fish raising and breeding method comprises the following steps: meets the requirements of international AAALAC authentication (authentication number: 001458).
The experimental steps are as follows:
1. zebra fish were randomly selected in 6-well plates with 15 tails per well.
2. Samples were given water-soluble, with normal and model controls set at 3mL per well.
3. Meanwhile, sodium chloride is given by water dissolution to establish a zebra fish skin water deficiency model.
Incubate at 4.28℃for 22h in the absence of light.
5. Each experimental group randomly selected 10 zebra fish, photographed under an dissecting microscope (see fig. 4 for partial results), analyzed and data collected by advanced image processing software, analyzed the tail area (S) of the zebra fish, calculated the moisturizing efficacy of the sample according to the following formula, and judged whether it has moisturizing efficacy.
The detection results are as follows:
| detecting items | Concentration of detection (%) | Efficacy (%) | Pi value | Detection result |
| Moisturizing efficacy | 0.05 | 62 | <0.01 | Statistically significant |
The detection result shows that the tail area of the sample group is obviously increased compared with that of the model control group, and the sample has obvious moisturizing effect.
Example 2: preparation of composition 2 of the invention and detection of oil control efficacy
Preparation of composition 2 of the invention
(1) Weighing 30g of the littoral cress callus culture filtrate, 30g of the alpine leonurus callus extract and 30g of the saussurea involucrata extract;
(2) Weighing 20g of soybean lecithin, dissolving in 50g of caprylic/capric triglyceride, and preparing 3 parts of mixture;
(3) Dissolving the coastal cress callus culture filtrate, the alpine leontopodium herb callus extract and the saussurea involucrata extract which are measured in the step (1) in 3 parts of the mixture prepared in the step (2) respectively, and fully dissolving the raw materials to obtain the coastal cress oil-soluble raw materials, the alpine leontopodium herb oil-soluble raw materials and the saussurea involucrata oil-soluble raw materials respectively;
(4) Measuring 50g of the coastal cress oil-soluble raw material, 10g of the alpine leontopodium oil-soluble raw material and 30g of the saussurea involucrata oil-soluble raw material in the step (3), uniformly mixing to obtain an oil-soluble raw material mixture, and adding 20g of sunflower seed oil unsaponifiable matter into the oil-soluble raw material mixture to obtain the composition.
The ratio of the amount of each raw material in the oil control composition provided in this example is shown in the following table:
oil control efficacy detection
The oil control detection method is the same as in example 1. The test results are shown in the following table:
the detection result shows that the fluorescence intensity of the sample in the sample group is obviously reduced compared with that in the model control group, and the sample has obvious oil control effect.
Example 3: preparation of composition 3 of the invention and detection of oil control efficacy
Preparation of composition 3 according to the invention
(1) Weighing 30g of the littoral cress callus culture filtrate, 30g of the alpine leonurus callus extract and 30g of the saussurea involucrata extract;
(2) Weighing 20g of soybean lecithin, dissolving in 50g of caprylic/capric triglyceride, and preparing 3 parts of mixture;
(3) Dissolving the coastal cress callus culture filtrate, the alpine leontopodium herb callus extract and the saussurea involucrata extract which are measured in the step (1) in 3 parts of the mixture prepared in the step (2) respectively, and fully dissolving the raw materials to obtain the coastal cress oil-soluble raw materials, the alpine leontopodium herb oil-soluble raw materials and the saussurea involucrata oil-soluble raw materials respectively;
(4) Measuring 50g of the coastal cress oil-soluble raw material, 10g of the alpine leontopodium oil-soluble raw material and 30g of the saussurea involucrata oil-soluble raw material in the step (3), uniformly mixing to obtain an oil-soluble raw material mixture, and adding 20g of sunflower seed oil unsaponifiable matter into the oil-soluble raw material mixture to obtain the composition.
The ratio of the amount of each raw material in the oil control composition provided in this example is shown in the following table:
oil control efficacy detection
The oil control detection method is the same as in example 1. The test results are shown in the following table:
the detection result shows that the fluorescence intensity of the sample in the sample group is obviously reduced compared with that in the model control group, and the sample has obvious oil control effect.
Comparative example 1: preparation of comparative composition 1 and oil control efficacy detection
Preparation of comparative composition 1
(1) Measuring 6g of coastal cress callus culture filtrate;
(2) Weighing 4g of soybean lecithin and dissolving in 90g of caprylic/capric triglyceride;
(3) Dissolving the littoral celery callus culture filtrate measured in the step (1) in the mixture prepared in the step (2), and fully dissolving the raw materials to obtain the comparative composition 1.
The proportions of the raw materials used in comparative composition 1 provided in this comparative example are shown in the following table:
oil control efficacy detection
The oil control detection method is the same as in example 1. The test results are shown in the following table:
comparative example 2: preparation of comparative composition 2 and oil control efficacy detection
Preparation of comparative composition 2
(1) Weighing 30g of the calli extract of the alpine leontopodium herb and 30g of the saussurea involucrata extract;
(2) Weighing 20g of soybean lecithin, dissolving in 50g of caprylic/capric triglyceride, and preparing 2 parts of mixture;
(3) Dissolving the alpine leontopodium herb callus extract and the saussurea involucrata extract measured in the step (1) in 3 parts of the mixture prepared in the step (2) respectively, and fully dissolving the raw materials to obtain the alpine leontopodium herb oil-soluble raw materials and the saussurea involucrata oil-soluble raw materials respectively;
(4) Measuring 20g of the alpine leontopodium oil-soluble raw materials and 40g of the saussurea involucrata oil-soluble raw materials in the step (3), uniformly mixing to obtain an oil-soluble raw material mixture, dissolving the oil-soluble raw material mixture in 20g of sunflower seed oil unsaponifiable matter, and then dissolving in 20g of caprylic acid/capric acid triglyceride oil to obtain the comparative composition 2.
The proportions of the raw materials used in comparative composition 2 provided in this comparative example are shown in the following table:
oil control efficacy detection
The oil control detection method is the same as in example 1. The test results are shown in the following table:
comparing the oil control efficacy of the compositions of examples 1-3 of the present invention with the oil control efficacy of the compositions of comparative examples 1-2, it can be seen that the oil control efficacy of the compositions of examples 1-3 of the present invention, which contain both coastal parsley and the active ingredients of snow lotus, alpine vetiver and sunflower seed, is unexpectedly improved and has a synergistic effect.
The foregoing has shown and described the basic principles and main features of the present invention and the advantages of the present invention. It will be understood by those skilled in the art that while the present invention is not limited to the foregoing embodiments, the foregoing embodiments and description are merely illustrative of the principles of this invention, and various changes and modifications may be made without departing from the spirit and scope of the invention, and these changes and modifications fall within the scope of the invention as hereinafter claimed. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (10)
1. A composition comprising an extract from coastal cress, an extract from sunflower seeds, an extract from alpine leonardite and an extract from saussurea involucrata.
2. The composition of claim 1, wherein the extract from coastal cress is a coastal cress extract or a coastal cress callus culture filtrate; the extract from the alpine leontopodium herb is a alpine leontopodium herb flower/leaf extract, an alpine leontopodium herb extract or an alpine leontopodium herb callus extract; the extract from saussurea involucrata is saussurea involucrata extract or saussurea involucrata cell culture; and/or the extract from sunflower seed is sunflower seed, sunflower seed oil, sunflower seed extract or sunflower seed oil unsaponifiable.
3. The composition according to claim 1 or 2, characterized in that it comprises the following components by weight:
3-15 parts of an extract from coastal cress, 8-12 parts of an extract from sunflower seeds, 1-5 parts of an extract from alpine leontopodium herb and 4-9 parts of an extract from saussurea involucrata; preferably 6-9 parts of the extract from coastal cress, 10 parts of the extract from sunflower seeds, 3 parts of the extract from alpine leontopodium herb and 6-8 parts of the extract from saussurea involucrata; more preferably 3 parts of said extract from coastal cress, 10 parts of said extract from sunflower seeds, 3 parts of said extract from alpine leontopodium herb and 6 parts of said extract from saussurea involucrata.
4. A composition according to any one of claims 1 to 3, wherein the composition further comprises caprylic/capric triglyceride and/or lecithin, e.g. the lecithin is soy lecithin or hydrogenated lecithin; preferably the composition further comprises 20-45 parts by weight of the caprylic/capric triglyceride and/or 8-18 parts by weight of the lecithin; more preferably the composition further comprises 25-40 parts by weight of the caprylic/capric triglyceride and/or 10-16 parts by weight of the lecithin; most preferably the composition further comprises 30-35 parts by weight of said caprylic/capric triglyceride and/or 12-14 parts by weight of said lecithin.
5. The composition of claim 4, wherein said composition comprises 3 parts of said extract from coastal cress, 10 parts of said extract from sunflower seeds, 3 parts of said extract from alpine leontopodium herb, 6 parts of said extract from saussurea involucrata, 20 parts of said caprylic/capric triglyceride and 8 parts of said lecithin.
6. A method of preparing a composition according to any one of claims 1 to 5, comprising dissolving lecithin in caprylic/capric triglyceride to obtain a mixture; respectively dissolving the extract from coastal thorny, the extract from alpine leontopodium herb and the extract from saussurea involucrata in the mixture to obtain coastal thorny oil-soluble raw materials, alpine leontopodium herb oil-soluble raw materials and saussurea involucrata oil-soluble raw materials; and adding said extract from sunflower seeds.
7. The method of manufacturing according to claim 6, wherein the method comprises the steps of:
(1) Measuring lecithin to be dissolved in caprylic/capric triglyceride to obtain the mixture;
(2) Respectively measuring the extract from coastal cress, the extract from alpine leontopodium herb and the extract from snow lotus herb, and respectively dissolving the extracts in the mixture prepared in the step (1) to obtain the coastal cress oil-soluble raw materials, the alpine leontopodium herb oil-soluble raw materials and the snow lotus herb oil-soluble raw materials; and
(3) Measuring and uniformly mixing the coastal cress oil-soluble raw material, the alpine leontopodium oil-soluble raw material and the saussurea involucrata oil-soluble raw material in the step (2) to obtain an oil-soluble raw material mixture, and then adding the extract from sunflower seeds into the oil-soluble raw material mixture to obtain the composition;
preferably the weight ratio of lecithin to caprylic/capric triglyceride is 2:5, a step of; more preferably the lecithin is soy lecithin or hydrogenated lecithin.
8. A cosmetic product, characterized in that it comprises a composition according to any one of claims 1 to 5.
9. A product as claimed in claim 7 wherein the product further comprises an emollient, an antioxidant, a surfactant, a fragrance, a preservative or a sunscreen, optionally further comprising a colorant.
10. The product according to claim 8 or 9, characterized in that it is a cleaning-type product, a care-type product or a make-up/finishing-type product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311551603.6A CN117338669A (en) | 2023-11-17 | 2023-11-17 | Oil control composition, preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311551603.6A CN117338669A (en) | 2023-11-17 | 2023-11-17 | Oil control composition, preparation method and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN117338669A true CN117338669A (en) | 2024-01-05 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202311551603.6A Pending CN117338669A (en) | 2023-11-17 | 2023-11-17 | Oil control composition, preparation method and application thereof |
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| Country | Link |
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| CN (1) | CN117338669A (en) |
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- 2023-11-17 CN CN202311551603.6A patent/CN117338669A/en active Pending
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