CN117327574B - Small peptide preparation device and small peptide preparation method - Google Patents
Small peptide preparation device and small peptide preparation method Download PDFInfo
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- CN117327574B CN117327574B CN202311633435.5A CN202311633435A CN117327574B CN 117327574 B CN117327574 B CN 117327574B CN 202311633435 A CN202311633435 A CN 202311633435A CN 117327574 B CN117327574 B CN 117327574B
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- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 69
- 238000002360 preparation method Methods 0.000 title claims abstract description 25
- 238000000746 purification Methods 0.000 claims abstract description 19
- 238000001914 filtration Methods 0.000 claims description 84
- 239000007788 liquid Substances 0.000 claims description 44
- 238000007789 sealing Methods 0.000 claims description 31
- 238000004140 cleaning Methods 0.000 claims description 17
- 238000003825 pressing Methods 0.000 claims description 13
- 230000009471 action Effects 0.000 claims description 10
- 239000000843 powder Substances 0.000 claims description 10
- 230000007246 mechanism Effects 0.000 claims description 9
- 238000001035 drying Methods 0.000 claims description 7
- 239000002994 raw material Substances 0.000 claims description 7
- 239000007921 spray Substances 0.000 claims description 4
- 102000004190 Enzymes Human genes 0.000 claims description 3
- 108090000790 Enzymes Proteins 0.000 claims description 3
- 230000000903 blocking effect Effects 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 claims description 3
- 239000003463 adsorbent Substances 0.000 abstract description 5
- 239000000463 material Substances 0.000 abstract description 5
- 239000002699 waste material Substances 0.000 abstract description 4
- 102000004196 processed proteins & peptides Human genes 0.000 description 9
- 238000009434 installation Methods 0.000 description 5
- 229920001184 polypeptide Polymers 0.000 description 5
- 239000004744 fabric Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 102000015636 Oligopeptides Human genes 0.000 description 2
- 108010038807 Oligopeptides Proteins 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000010828 elution Methods 0.000 description 2
- 210000001503 joint Anatomy 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 231100000245 skin permeability Toxicity 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M21/00—Bioreactors or fermenters specially adapted for specific uses
- C12M21/18—Apparatus specially designed for the use of free, immobilized or carrier-bound enzymes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D29/00—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor
- B01D29/96—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor in which the filtering elements are moved between filtering operations; Particular measures for removing or replacing the filtering elements; Transport systems for filters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
- C12M33/14—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus with filters, sieves or membranes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
- C12M37/04—Seals
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/12—Purification
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/14—Drying
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/10—Process efficiency
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Abstract
The invention discloses a small peptide preparation device and a small peptide preparation method, and relates to the field of small peptide preparation. According to the invention, the filter assembly can be automatically unlocked when the filter assembly is seriously blocked, so that the subsequent disassembly of the filter assembly is more convenient, and the filter assembly is outwards ejected, so that a worker can observe corresponding conditions conveniently, the filter assembly can be replaced in time at proper time, the labor intensity of manpower is reduced, the waste of materials such as an adsorbent is avoided, and the purification quality of a small peptide solution is further improved; the quick disassembly and replacement of the filter assembly can be realized through the matching of the locking assembly and the thrust assembly, so that the disassembly, assembly and replacement time of the filter assembly is greatly reduced, and the equipment can quickly recover to normal operation; through the cooperation of valve rod and filter component, not only make the switching control of feed liquor pipe more convenient, can also pop out the time with feed liquor pipe self-closing at filter component unblock to prevent that the feed liquor pipe from continuing the feed liquor.
Description
Technical Field
The invention belongs to the field of small peptide preparation, and particularly relates to a small peptide preparation device and a small peptide preparation method.
Background
Small peptides are a class of polypeptides, generally having a molecular weight of 1000 daltons or less, and are also known as oligopeptides, oligopeptides or as small molecule active peptides, wherein 2 to 10 amino acids are condensed with each other. Small peptides with small molecular weight can have higher skin permeability than polypeptides and are easier to be absorbed by human skin, and meanwhile, biological activity is greatly improved due to the fact that the molecular weight is small to a certain extent. The smaller the peptide molecular weight, the shorter the "amino acid chain" is, and the easier the peptide is absorbed and utilized by human body, so that the application of the small peptide is wider at present. The main preparation steps of the small peptide at present mainly comprise: crushing raw materials, preparing a small peptide solution by enzymolysis, filtering and purifying the small peptide solution, and drying to prepare powder. When the small peptide solution is filtered and purified, the filtering assembly can be gradually blocked by impurities intercepted by the filtering assembly along with continuous filtration of the filtering assembly, so that the filtering efficiency and the filtering effect of the filtering assembly are affected.
Chinese patent CN212882339U discloses a polypeptide purification preparation facilities, including polypeptide purification preparation facilities body and vibrator, through setting up the heating pipe, can improve reaction efficiency, atmospheric pressure tubular column and evacuating device's setting, for the barrel pressurization through the vacuum pump, atmospheric pressure tubular column sets for atmospheric pressure, can increase to suitable atmospheric pressure, make elution rate accelerate, avoid flowing out along with the liquid and the condition that the elution rate slows down that leads to with the loss of air, through setting up spring and fastener, make the screen cloth be convenient for install and dismantle, the screen cloth is conveniently taken down to clear up and pack the adsorbent, the purification efficiency of polypeptide has been improved, through adopting the rolling disc rotation, make the barrel automatic reversal, thereby reach sample and eluent abundant contact absorbing purpose. However, after the filtering effect of the screen is poor, a corresponding instruction cannot be sent out in time, the screen can be replaced according to experience, the labor intensity of workers is improved and the waste of the adsorbent in the screen is caused due to the fact that the screen is replaced too early, and the purification quality of the solution is reduced due to the fact that the screen is replaced too late; and the screen cloth dismouting change process is comparatively loaded down with trivial details, has prolonged the change time of screen cloth, influences the normal work of equipment easily.
Disclosure of Invention
Aiming at the problems in the related art, the invention provides a small peptide preparation device and a small peptide preparation method, so as to overcome the technical problems in the prior art.
In order to solve the technical problems, the invention is realized by the following technical scheme:
the invention relates to a small peptide preparation device which comprises an enzymolysis reaction kettle, a purification tank and a dryer, wherein the purification tank comprises a tank body, the bottom end of the tank body is provided with a liquid inlet pipe communicated with the enzymolysis reaction kettle, the top end of the tank body is provided with a liquid outlet pipe communicated with the dryer, and a filtering mechanism positioned between the liquid inlet pipe and the liquid outlet pipe is arranged in the tank body;
the filtering mechanism comprises a filtering component, a locking component and a thrust component, wherein the filtering component is inserted and installed in the tank body from the outer wall of one side of the tank body, the locking component pushes the inserted filtering component downwards to fix the filtering component in a locking way, and the thrust component is extruded and contracted to generate reset elastic force when the filtering component is inserted and installed;
when the filtering component is gradually blocked due to continuous filtering, the filtering speed of the filtering component is reduced, so that the hydraulic pressure at the lower end of the tank body is gradually increased, when the hydraulic pressure is larger than the locking force of the locking component on the filtering component, the filtering component is pushed upwards by the hydraulic pressure to move so that the locking component is unlocked, and meanwhile, the outer side end of the filtering component is popped up from the side wall of the tank body under the pushing of the pushing component, so that the preliminary disassembly of the filtering component is completed;
the liquid inlet pipe is provided with a push type valve for controlling the opening and closing of the liquid inlet pipe, and a valve rod extending upwards is arranged in the push type valve;
when the filter assembly moves downwards under the pushing of the locking assembly, the filter assembly synchronously pushes the valve rod downwards so as to open the push-type valve; when the filter component moves upwards under the action of hydraulic pressure, the valve rod is not subjected to pushing pressure, and the push type valve is reset and closed.
Further, the filtering component comprises a plate frame, a notch and a supporting frame, wherein the notch is formed in the side wall of the tank body, the supporting frame is fixedly installed on the inner wall of the tank body, and a clamping groove is formed in the top surface of the supporting frame;
the inner ring of the plate frame is fixedly provided with a filter plate, and the bottom surface of the plate frame is fixedly provided with a clamping strip corresponding to the clamping groove.
Further, the locking assembly comprises a plurality of fixing seats and limiting pressing blocks, the plurality of fixing seats are sequentially arranged above the notch along the inner wall of the tank body, and the bottom end of each fixing seat is provided with a slideway;
the limiting press block is slidably mounted in the slide way, a second pressure spring is mounted on the top end of the limiting press block in a butt joint mode, the lower end of the limiting press block extends to the lower portion of the fixing seat, and a guide inclined plane is arranged at the bottom end of the limiting press block in the direction towards the notch.
Further, the outer side end of the plate frame is provided with a sealing plate, a plurality of lifting sliding grooves are formed in the connecting end of the sealing plate and the plate frame, and a plurality of lifting sliding blocks which are in one-to-one sliding clamping connection with the lifting sliding grooves are fixedly installed on the outer side end of the plate frame.
Further, a sliding hole communicated with the lifting sliding groove is formed in the sealing plate, a pin hole corresponding to the sliding hole is formed in the lifting sliding block, a pin shaft is slidably arranged in the sliding hole, a first pressure spring is arranged at the inner side end of the pin shaft in an abutting mode, and the outer side end of the pin shaft extends to the outer portion of the sliding hole and is provided with an arc-shaped end head.
Further, the thrust component comprises a plurality of telescopic seats, the telescopic seats are arranged on one side wall of the tank body opposite to the notch, a pushing block is slidably arranged in the telescopic seats, one end of the pushing block is abutted to a thrust spring, and the other end of the pushing block is sealed and slidably extended into the tank body.
Further, the push type valve comprises a valve body arranged on the liquid inlet pipe, a valve cavity communicated with the liquid inlet pipe is arranged in the valve body, a valve core used for blocking the valve cavity is slidably arranged in the valve cavity, and a guide groove in sliding clamping connection with the valve core is arranged at the bottom end of the valve cavity;
the upper end of the valve body is provided with a limit chute, the bottom end of the limit chute is fixedly provided with a sealing bottom plate, the lower end of the valve rod penetrates through the sealing bottom plate in a sliding manner and is fixedly connected with the valve core, and the top end of the valve rod is inserted on the support frame in a sliding manner and extends into the clamping groove;
an end plate fixedly mounted on the valve rod is arranged in the limiting chute, and a reset spring which is abutted between the end plate and the sealing bottom plate is sleeved at the lower end of the valve rod.
Further, a cleaning pipe is arranged at the top end of the tank body, and a cleaning spray head is connected and arranged at the bottom end of the cleaning pipe.
The invention also discloses a small peptide preparation method, which uses the small peptide preparation device, and comprises the following specific steps:
s1: cleaning and drying the raw materials, and crushing the raw materials by an ultrafine grinder to obtain ultrafine powder;
s2: adding the superfine powder into an enzymolysis reaction kettle, and simultaneously adding compound enzyme to prepare a small peptide solution through enzymolysis reaction;
s3: conveying the small peptide solution into a purification tank through a liquid inlet pipe, filtering and purifying the small peptide solution by a filtering component, conveying the small peptide solution to a dryer through a liquid outlet pipe, and drying and concentrating the purified small peptide solution by the dryer to obtain small peptide powder;
s4: when the filtering component is gradually blocked due to continuous filtering, the filtering speed of the filtering component is reduced, so that the hydraulic pressure at the lower end of the tank body is gradually increased, when the hydraulic pressure is larger than the locking force of the locking component on the filtering component, the filtering component is pushed upwards by the hydraulic pressure to be moved, the locking component is unlocked, meanwhile, the valve rod is not pushed by the pushing pressure of the filtering component any more, the push-type valve is reset and closed, the liquid inlet pipe is not fed any more, and the outer end of the filtering component is pushed by the pushing component to be ejected from the side wall of the tank body, so that the preliminary disassembly of the filtering component is completed;
s5: after the filtered and purified small peptide solution above the filter assembly is discharged, the inserted filter assembly is extracted, a new filter assembly is inserted and installed in the tank body from the outer wall of one side of the tank body, and the filter assembly after insertion is pushed downwards by the locking assembly to be moved so as to lock and fix the filter assembly, thereby completing quick disassembly and replacement of the filter assembly.
The invention has the following beneficial effects:
1. when the filtering component is gradually blocked due to continuous filtering, the filtering speed of the filtering component is reduced, so that the hydraulic pressure at the lower end of the tank body is gradually increased, and when the hydraulic pressure is larger than the locking force of the locking component on the filtering component, the filtering component is pushed upwards by the hydraulic pressure to move so that the locking component is unlocked, and the outer side end of the filtering component is ejected from the side wall of the tank body under the pushing of the pushing component; the automatic unlocking device can automatically unlock the filter assembly when the filter assembly is blocked seriously, so that the subsequent disassembly of the filter assembly is more convenient, and meanwhile, the filter assembly is outwards ejected, so that corresponding conditions can be observed by workers conveniently, the filter assembly can be replaced in time at proper time, the labor intensity of workers is reduced, the waste of materials such as an adsorbent is avoided, and the purification quality of a small peptide solution is further improved.
2. According to the invention, after the filter assembly is ejected, a worker can withdraw the inserted filter assembly, then insert and install a new filter assembly in the tank body from the outer wall of one side of the tank body, and the locking assembly pushes the inserted filter assembly downwards to lock and fix the filter assembly, so that the quick disassembly and replacement of the filter assembly are completed, the disassembly and replacement time of the filter assembly can be greatly reduced, and the equipment can quickly recover to normal operation.
3. According to the invention, when the filtering component is pushed by the locking component to move downwards, the valve rod is synchronously pushed downwards by the filtering component to open the push-type valve, the liquid inlet pipe starts to feed liquid, and when the filtering component is pushed upwards under the action of hydraulic pressure, the valve rod is not pushed by pushing pressure, at the moment, the push-type valve is reset and closed, and the liquid inlet pipe stops feeding liquid; through the cooperation of valve rod and filter component, not only make the switching control of feed liquor pipe more convenient, can also pop out the feed liquor pipe self-closing when filter component unblock to prevent that the feed liquor pipe from lasting feed liquor, and make the small peptide solution ooze from filter component grafting department, thereby guarantee the normal work of equipment.
Of course, it is not necessary for any one product to practice the invention to achieve all of the advantages set forth above at the same time.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the invention, the drawings that are needed for the description of the embodiments will be briefly introduced below, it being obvious that the drawings in the following description are only some embodiments of the invention, and that it is also possible for a person skilled in the art to obtain the drawings from these drawings without inventive effort.
FIG. 1 is a schematic diagram showing the three-dimensional structure of a small peptide production apparatus of the present invention;
FIG. 2 is a schematic view showing a three-dimensional cut-away structure of the purification tank of the present invention when a filter mechanism is installed therein;
FIG. 3 is a schematic view of the structure of the present invention shown in FIG. 2 at a partially enlarged scale;
FIG. 4 is a schematic view of the structure of the present invention shown in FIG. 2 at B in a partially enlarged manner;
FIG. 5 is a schematic view of the structure of the present invention shown in FIG. 2 at C in a partially enlarged manner;
FIG. 6 is a schematic view of a partially enlarged structure of the invention at D of FIG. 2;
FIG. 7 is a schematic view showing a three-dimensional sectional structure of the purification tank of the present invention when the filtration mechanism is assembled and disassembled;
FIG. 8 is a schematic view of a partially enlarged structure of FIG. 7E according to the present invention;
FIG. 9 is a schematic perspective view of a purification tank according to the present invention.
In the figure: 1. an enzymolysis reaction kettle; 2. a purification tank; 21. a tank body; 22. a liquid inlet pipe; 23. a liquid outlet pipe; 24. cleaning the tube; 25. cleaning the spray head; 3. a dryer; 4. a filtering mechanism; 41. a plate frame; 42. a fixing seat; 43. a telescopic seat; 44. a filter plate; 45. a notch; 46. a sealing plate; 47. lifting sliding grooves; 48. a lifting slide block; 49. a slide hole; 410. a first pressure spring; 411. a pin shaft; 412. a pin hole; 413. a support frame; 414. clamping strips; 415. a clamping groove; 416. a slideway; 417. limiting pressing blocks; 418. a second pressure spring; 419. a thrust spring; 420. pushing blocks; 5. a push valve; 51. a valve stem; 52. a valve body; 53. a valve cavity; 54. a valve core; 55. a guide groove; 56. limiting sliding grooves; 57. an end plate; 58. a return spring; 59. and sealing the bottom plate.
Detailed Description
The following description of the technical solutions in the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is apparent that the described embodiments are only some embodiments of the present invention, not all embodiments. All other embodiments, based on the embodiments in the invention, which a person of ordinary skill in the art would obtain without inventive faculty, are within the scope of the invention.
In the description of the present invention, it should be understood that the terms "open," "upper," "lower," "top," "middle," "inner," and the like indicate an orientation or positional relationship, merely for convenience of description and to simplify the description, and do not indicate or imply that the components or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus should not be construed as limiting the invention.
Referring to fig. 1 and 2, the invention discloses a small peptide preparation device, which comprises an enzymolysis reaction kettle 1, a purification tank 2 and a dryer 3, wherein the purification tank 2 comprises a tank body 21, a liquid inlet pipe 22 communicated with the enzymolysis reaction kettle 1 is arranged at the bottom end of the tank body 21, a liquid outlet pipe 23 communicated with the dryer 3 is arranged at the top end of the tank body 21, and a filtering mechanism 4 positioned between the liquid inlet pipe 22 and the liquid outlet pipe 23 is arranged in the tank body 21;
the filtering mechanism 4 comprises a filtering component, a locking component and a thrust component, wherein the filtering component is inserted and installed in the tank body 21 from the outer wall of one side of the tank body 21, the locking component pushes the inserted filtering component downwards to move so as to lock and fix the filtering component, and the thrust component is extruded and contracted to generate reset elastic force when the filtering component is inserted and installed;
when the filter assembly is gradually blocked due to continuous filtration, the filtration speed of the filter assembly is reduced, so that the hydraulic pressure of the lower end of the inner part of the tank body 21 is gradually increased, and when the hydraulic pressure is larger than the locking force of the locking assembly on the filter assembly, the hydraulic pressure pushes the filter assembly upwards to move, so that the locking assembly is unlocked, and meanwhile, the outer end of the filter assembly is ejected from the side wall of the tank body 21 under the pushing of the pushing assembly, so that the preliminary disassembly of the filter assembly is completed;
the liquid inlet pipe 22 is provided with a push valve 5 for controlling the opening and closing of the liquid inlet pipe 22, and a valve rod 51 extending upwards is arranged in the push valve 5;
when the filter assembly moves downwards under the pushing of the locking assembly, the filter assembly synchronously pushes the valve rod 51 downwards so as to open the push-type valve 5; when the filter assembly moves upwards under the action of hydraulic force, the valve rod 51 is not subjected to pushing pressure any more, and at the moment, the push type valve 5 is reset and closed;
according to the invention, the filter assembly can be automatically unlocked when the filter assembly is seriously blocked, so that the subsequent disassembly of the filter assembly is more convenient, and the filter assembly is outwards ejected, so that a worker can observe corresponding conditions conveniently, the filter assembly can be replaced in time at proper time, the labor intensity of manpower is reduced, the waste of materials such as an adsorbent is avoided, and the purification quality of a small peptide solution is further improved; the quick disassembly and replacement of the filter assembly can be realized through the matching of the locking assembly and the thrust assembly, so that the disassembly, assembly and replacement time of the filter assembly is greatly reduced, and the equipment can quickly recover to normal operation; through the cooperation of valve rod 51 and filter component, not only make the switching control of feed liquor pipe 22 more convenient, can also pop out the feed liquor pipe 22 self-closing when filter component unblock to prevent that feed liquor pipe 22 from continuing the feed liquor, and make the interior liquid level of jar body 21 continuously rise and lead to the small peptide solution to ooze from filter component grafting department.
Referring to fig. 2-4, 7 and 8, in one embodiment, the filtering assembly includes a plate frame 41, a slot 45 and a supporting frame 413, the slot 45 is formed on a side wall of the tank 21, the supporting frame 413 is fixedly mounted on an inner wall of the tank 21, and a clamping groove 415 is formed on a top surface of the supporting frame 413; the inner ring of the plate frame 41 is fixedly provided with a filter plate 44, and the bottom surface of the plate frame 41 is fixedly provided with a clamping strip 414 corresponding to the clamping groove 415; the locking assembly comprises a plurality of fixing seats 42 and limiting press blocks 417, the fixing seats 42 are arranged, the plurality of fixing seats 42 are sequentially arranged above the notch 45 along the inner wall of the tank body 21, and a slide way 416 is arranged at the bottom end of the fixing seat 42; the limiting press block 417 is slidably mounted in the slideway 416, a second pressure spring 418 is mounted at the top end of the limiting press block 417 in a butt joint manner, the lower end of the limiting press block 417 extends to the lower side of the fixed seat 42, and a guide inclined plane is arranged at the bottom end of the limiting press block 417 towards the direction of the notch 45;
when the filter plate 44 is installed, the plate frame 41 and the filter plate 44 are gradually inserted inwards from the notch 45, the plate frame 41 pushes the limiting pressing block 417 upwards through a guide inclined plane at the bottom end of the limiting pressing block 417 in the inserting process, so that the limiting pressing block 417 is contracted inwards towards the slide way 416, the second pressure spring 418 is extruded and contracted, when the plate frame 41 is completely inserted into the tank body 21, the clamping strip 414 at the bottom of the plate frame 41 is just positioned above the corresponding clamping groove 415, at the moment, the limiting pressing block 417 moves downwards under the action of the reset elastic force of the second pressure spring 418, and the plate frame 41 is pushed downwards, so that the clamping strip 414 is clamped in the clamping groove 415, at the moment, the plate frame 41 is locked and fixed under the clamping limiting of the clamping strip 414 and the abutting action of the limiting pressing block 417, and therefore the installation of the plate frame 41 and the filter plate 44 is completed;
when the filter plate 44 is gradually blocked due to continuous filtration, the filtration speed of the filter plate 44 is reduced, so that the hydraulic pressure at the lower end of the inner part of the tank body 21 is gradually increased, when the hydraulic pressure is larger than the reset elastic force of the second pressure spring 418, the hydraulic pressure pushes the filter plate 44 and the plate frame 41 upwards to move, and then the clamping strip 414 is driven to move upwards, and when the clamping strip 414 moves out of the clamping groove 415, the clamping strip 414 and the plate frame 41 are not limited by the clamping groove 415 any more.
Referring to fig. 2, 3 and 7, in one embodiment, a sealing plate 46 is disposed at an outer end of the plate frame 41, a plurality of lifting sliding grooves 47 are disposed at a connection end of the sealing plate 46 and the plate frame 41, and a plurality of lifting sliding blocks 48 are fixedly mounted at an outer end of the plate frame 41 and are slidably clamped with the lifting sliding grooves 47 in a one-to-one correspondence manner;
when the plate frame 41 is completely inserted into the tank body 21, the sealing plate 46 is clamped in the notch 45, the notch 45 is sealed, the subsequent small peptide solution is prevented from leaking outwards from the notch 45, meanwhile, the plate frame 41 moves downwards under the pressure of the limiting pressing block 417 to finish installation locking, and at the moment, the plate frame 41 and the sealing plate 46 slide relatively in a matched mode through the lifting sliding groove 47 and the lifting sliding block 48, so that the sealing plate 46 is kept motionless, the clamping and sealing are continued in the notch 45, and the sealing effect on the notch 45 is guaranteed.
Referring to fig. 2 and 3, in one embodiment, a sliding hole 49 is formed in the sealing plate 46 and is communicated with the lifting sliding chute 47, a pin hole 412 corresponding to the sliding hole 49 is formed on the lifting sliding block 48, a pin shaft 411 is slidably mounted in the sliding hole 49, a first pressure spring 410 is mounted at the inner end of the pin shaft 411 in an abutting manner, and the outer end of the pin shaft 411 extends to the outside of the sliding hole 49 and is provided with an arc-shaped end;
when the plate frame 41 slides downwards relative to the sealing plate 46 to finish installation, the pin holes 412 are aligned with the sliding holes 49, and at the moment, the pin shafts 411 move towards the pin holes 412 under the drive of the elastic force of the first pressure spring 410, so that arc-shaped end heads at the outer ends of the pin shafts 411 are clamped in the pin holes 412, the plate frame 41 and the sealing plate 46 are fixed through pin shafts 411, the installation stability of the plate frame 41 is improved, and the filter plates 44 and the plate frame 41 are prevented from slowly moving upwards under the action of hydraulic force when the hydraulic force at the lower end of the inner part of the tank body 21 is gradually increased due to gradual blockage caused by continuous filtration; when the filter plate 44 is blocked seriously, the hydraulic pressure at the lower end of the inner part of the tank body 21 is increased to a certain extent, so that the hydraulic pressure borne by the filter plate 44 is larger than the locking force of the pin shaft 411, the arc-shaped end of the pin shaft 411 is retracted into the sliding hole 49 under the abutting connection of the plate frame 41, the plate frame 41 is unlocked, the plate frame 41 and the filter plate 44 move upwards under the hydraulic pressure, the clamping strip 414 is driven to move out of the clamping groove 415, and the clamping strip 414 and the plate frame 41 are not limited by the clamping of the clamping groove 415.
Referring to fig. 2, 5, 7 and 8, in one embodiment, the thrust assembly includes a plurality of telescopic seats 43, the plurality of telescopic seats 43 are mounted on a side wall of the tank 21 opposite to the notch 45, a pushing block 420 is slidably mounted in the telescopic seats 43, one end of the pushing block 420 is abutted to and mounted with a thrust spring 419, and the other end of the pushing block 420 is hermetically and slidably extended into the tank 21;
when the plate frame 41 is inserted and installed in the tank body 21, the plate frame 41 pushes the pushing block 420 to move towards the inside of the telescopic seat 43, meanwhile, the thrust spring 419 is extruded and contracted to generate reset elastic force, when the plate frame 41 is moved upwards and unlocked under the action of hydraulic force, the plate frame 41 and the pushing block 420 are pushed outwards to move under the action of the reset elastic force of the thrust spring 419, and meanwhile, the plate frame 41 pushes the sealing plate 46 outwards for a certain distance, so that a worker can observe the installation condition of the sealing plate 46 conveniently, and the plate frame 41 and the filter plate 44 can be replaced timely;
wherein the push reset distance of the push spring 419 is smaller than the thickness of the sealing plate 46, thereby preventing the sealing plate 46 from being completely pushed out of the notch 45, so that the notch 45 maintains a sealed state, and small peptide solution above the filter plate 44 is prevented from flowing out of the notch 45.
Referring to fig. 2-8, in one embodiment, the push valve 5 includes a valve body 52 mounted on the liquid inlet pipe 22, a valve cavity 53 communicated with the liquid inlet pipe 22 is disposed in the valve body 52, a valve core 54 for blocking the valve cavity 53 is slidably mounted in the valve cavity 53, and a guide groove 55 slidably clamped with the valve core 54 is disposed at the bottom end of the valve cavity 53; the upper end of the valve body 52 is provided with a limit chute 56, the bottom end of the limit chute 56 is fixedly provided with a sealing bottom plate 59, the lower end of the valve rod 51 slides through the sealing bottom plate 59 and is fixedly connected with the valve core 54, and the top end of the valve rod 51 is slidably inserted on the support frame 413 and extends into the clamping groove 415; an end plate 57 fixedly mounted on the valve rod 51 is arranged in the limit chute 56, and a return spring 58 which is abutted between the end plate 57 and a sealing bottom plate 59 is sleeved at the lower end of the valve rod 51;
when the clamping strip 414 is clamped into the clamping groove 415 in a descending manner, the clamping strip 414 enables the valve rod 51 to move in a downward abutting manner, at the moment, the valve rod 51 pushes the valve core 54 downwards, so that the valve core 54 moves from the valve cavity 53 into the guide groove 55 and does not seal the valve cavity 53, at the moment, the push type valve 5 is in a conducting state, and the valve rod 51 drives the end plate 57 to synchronously descend in a descending manner, so that the reset spring 58 is extruded and contracted to generate reset elastic force; when the clamping strip 414 moves upwards to separate from the clamping groove 415, the valve rod 51 is not limited by the extrusion of the clamping strip 414, at the moment, the end plate 57 and the valve rod 51 move upwards to reset under the action of the reset elastic force of the reset spring 58, and drive the valve core 54 to move upwards to reset, so that the valve core 54 separates the valve cavity 53, at the moment, the push type valve 5 is in a closed state, the liquid inlet pipe 22 does not convey the small peptide solution into the tank 21, and the inlet end of the liquid outlet pipe 23 extends to a position close to the upper surface of the filter plate 44, so that the liquid outlet pipe 23 can discharge the small peptide solution filtered and purified above the filter plate 44, and the new plate frame 41 and the filter plate 44 can be conveniently extracted and replaced.
Referring to fig. 2, in one embodiment, a cleaning pipe 24 is installed at the top end of the tank 21, and a cleaning nozzle 25 is installed at the bottom end of the cleaning pipe 24; after the equipment works, the cleaning pipe 24 and the cleaning nozzle 25 are matched to spray and clean the tank body 21, so that the cleaning of the tank body 21 is recovered.
Referring to fig. 1-9, in one embodiment, a method for preparing small peptides is also disclosed, comprising the following steps:
s1: cleaning and drying the raw materials, and crushing the raw materials by an ultrafine grinder to obtain ultrafine powder;
s2: adding the superfine powder into an enzymolysis reaction kettle 1, and simultaneously adding compound enzyme to prepare a small peptide solution through enzymolysis reaction;
s3: conveying the small peptide solution into the purification tank 2 through a liquid inlet pipe 22, filtering and purifying the small peptide solution by a filtering component, conveying the small peptide solution to a dryer 3 through a liquid outlet pipe 23, and drying and concentrating the purified small peptide solution by the dryer 3 to obtain small peptide powder;
s4: when the filter assembly is gradually blocked due to continuous filtration, the filtration speed of the filter assembly is reduced, so that the hydraulic pressure at the lower end of the inner part of the tank body 21 is gradually increased, when the hydraulic pressure is larger than the locking force of the locking assembly on the filter assembly, the hydraulic pressure pushes the filter assembly upwards to move, so that the locking assembly is unlocked, meanwhile, the valve rod 51 is not pushed by the pushing pressure of the filter assembly any more, the push type valve 5 is reset to be closed, the liquid inlet pipe 22 is not fed any more, and the outer end of the filter assembly is ejected out of the side wall of the tank body 21 under the pushing of the pushing assembly, so that the preliminary disassembly of the filter assembly is completed;
s5: after the filtered and purified small peptide solution above the filter component is discharged, the inserted filter component is extracted, a new filter component is inserted and installed in the tank body 21 from the outer wall of one side of the tank body 21, and the filter component after being inserted is pushed downwards by the locking component to be moved so as to lock and fix the filter component, thereby completing quick disassembly and replacement of the filter component.
In the description of the present specification, the descriptions of the terms "one embodiment," "example," "specific example," and the like, mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiments or examples. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
The above disclosed preferred embodiments of the invention are merely intended to help illustrate the invention. The preferred embodiments are not exhaustive or to limit the invention to the precise form disclosed. Obviously, many modifications and variations are possible in light of the above teaching. The embodiments were chosen and described in order to best explain the principles of the invention and the practical application, to thereby enable others skilled in the art to best understand and utilize the invention.
Claims (5)
1. The utility model provides a small peptide preparation facilities, includes enzymolysis reaction kettle (1), purification jar (2) and desiccator (3), its characterized in that: the purifying tank (2) comprises a tank body (21), a liquid inlet pipe (22) communicated with the enzymolysis reaction kettle (1) is arranged at the bottom end of the tank body (21), a liquid outlet pipe (23) communicated with the dryer (3) is arranged at the top end of the tank body (21), and a filtering mechanism (4) positioned between the liquid inlet pipe (22) and the liquid outlet pipe (23) is arranged in the tank body (21);
the filtering mechanism (4) comprises a filtering component, a locking component and a thrust component, wherein the filtering component is inserted and installed in the tank body (21) from the outer wall of one side of the tank body (21), the locking component pushes the inserted filtering component downwards to fix the filtering component in a locking way, and the thrust component is extruded and contracted to generate reset elastic force when the filtering component is inserted and installed;
when the filter assembly is gradually blocked due to continuous filtration, the filtration speed of the filter assembly is reduced, so that the hydraulic pressure at the lower end of the inside of the tank body (21) is gradually increased, and when the hydraulic pressure is larger than the locking force of the locking assembly on the filter assembly, the hydraulic pressure pushes the filter assembly upwards to move, so that the locking assembly is unlocked, and meanwhile, the outer end of the filter assembly is ejected from the side wall of the tank body (21) under the pushing of the pushing assembly, so that the preliminary disassembly of the filter assembly is completed;
a push type valve (5) for controlling the opening and closing of the liquid inlet pipe (22) is arranged on the liquid inlet pipe (22), and a valve rod (51) extending upwards is arranged in the push type valve (5);
when the filter assembly moves downwards under the pushing of the locking assembly, the filter assembly synchronously pushes the valve rod (51) downwards, so that the push type valve (5) is opened; when the filter assembly moves upwards under the action of hydraulic pressure, the valve rod (51) is not subjected to pushing pressure any more, and at the moment, the push type valve (5) is reset and closed;
the filter assembly comprises a plate frame (41), a notch (45) and a support frame (413), wherein the notch (45) is formed in the side wall of the tank body (21), the support frame (413) is fixedly arranged on the inner wall of the tank body (21), and a clamping groove (415) is formed in the top surface of the support frame (413);
the inner ring of the plate frame (41) is fixedly provided with a filter plate (44), and the bottom surface of the plate frame (41) is fixedly provided with a clamping strip (414) corresponding to the clamping groove (415);
the locking assembly comprises a plurality of fixing seats (42) and limiting pressing blocks (417), wherein the fixing seats (42) are arranged, the fixing seats (42) are sequentially arranged above the notches (45) along the inner wall of the tank body (21), and a slideway (416) is arranged at the bottom end of the fixing seat (42);
the limiting pressing block (417) is slidably mounted in the slideway (416), a second pressure spring (418) is mounted at the top end of the limiting pressing block (417) in an abutting mode, the lower end of the limiting pressing block (417) extends to the lower portion of the fixing seat (42), and a guide inclined plane is arranged at the bottom end of the limiting pressing block (417) towards the direction of the notch (45);
the thrust assembly comprises a plurality of telescopic seats (43), the telescopic seats (43) are arranged on one side wall of the tank body (21) opposite to the notch (45), a pushing block (420) is slidably arranged in the telescopic seats (43), one end of the pushing block (420) is abutted to a thrust spring (419), and the other end of the pushing block (420) is hermetically and slidably extended into the tank body (21);
the push type valve (5) comprises a valve body (52) arranged on the liquid inlet pipe (22), a valve cavity (53) communicated with the liquid inlet pipe (22) is arranged in the valve body (52), a valve core (54) used for blocking the valve cavity (53) is slidably arranged in the valve cavity (53), and a guide groove (55) which is slidably clamped with the valve core (54) is formed in the bottom end of the valve cavity (53);
the upper end of the valve body (52) is provided with a limit chute (56), the bottom end of the limit chute (56) is fixedly provided with a sealing bottom plate (59), the lower end of the valve rod (51) penetrates through the sealing bottom plate (59) in a sliding mode and is fixedly connected with the valve core (54), and the top end of the valve rod (51) is inserted on the supporting frame (413) in a sliding mode and extends into the clamping groove (415);
an end plate (57) fixedly mounted on the valve rod (51) is arranged in the limiting chute (56), and a return spring (58) abutted between the end plate (57) and the sealing bottom plate (59) is sleeved at the lower end of the valve rod (51).
2. The small peptide preparation device according to claim 1, wherein: the outer side end of the plate frame (41) is provided with a sealing plate (46), a plurality of lifting sliding grooves (47) are formed in the connecting end of the sealing plate (46) and the plate frame (41), and a plurality of lifting sliding blocks (48) which are in one-to-one corresponding sliding clamping connection with the lifting sliding grooves (47) are fixedly arranged at the outer side end of the plate frame (41).
3. The small peptide preparation device according to claim 2, wherein: the sealing plate (46) is internally provided with a sliding hole (49) communicated with the lifting sliding groove (47), the lifting sliding block (48) is provided with a pin hole (412) corresponding to the sliding hole (49), the inside of the sliding hole (49) is slidably provided with a pin shaft (411), the inner side end of the pin shaft (411) is abutted to be provided with a first pressure spring (410), and the outer side end of the pin shaft (411) extends to the outside of the sliding hole (49) and is provided with an arc-shaped end head.
4. The small peptide preparation device according to claim 1, wherein: the top of the tank body (21) is provided with a cleaning pipe (24), and the bottom of the cleaning pipe (24) is connected with a cleaning spray head (25).
5. A preparation method of small peptide is characterized in that: use of a small peptide preparation device according to any one of claims 1-4, comprising the following steps:
s1: cleaning and drying the raw materials, and crushing the raw materials by an ultrafine grinder to obtain ultrafine powder;
s2: adding the superfine powder into an enzymolysis reaction kettle (1), and simultaneously adding compound enzyme to prepare a small peptide solution through enzymolysis reaction;
s3: conveying the small peptide solution into a purification tank (2) through a liquid inlet pipe (22), filtering and purifying the small peptide solution by a filtering component, conveying the small peptide solution to a dryer (3) through a liquid outlet pipe (23), and drying and concentrating the purified small peptide solution by the dryer (3) to obtain small peptide powder;
s4: when the filter assembly is gradually blocked due to continuous filtration, the filtration speed of the filter assembly is reduced, so that the hydraulic pressure at the lower end inside the tank body (21) is gradually increased, when the hydraulic pressure is larger than the locking force of the locking assembly on the filter assembly, the hydraulic pressure pushes the filter assembly upwards to move, so that the locking assembly is unlocked, meanwhile, the valve rod (51) is not subjected to the pushing pressure of the filter assembly any more, the push type valve (5) is reset and closed, the liquid inlet pipe (22) is not fed any more, and the outer end of the filter assembly is ejected from the side wall of the tank body (21) under the pushing of the pushing assembly, so that the preliminary disassembly of the filter assembly is completed;
s5: after the filtered and purified small peptide solution above the filtering component is discharged, the inserted filtering component is extracted, a new filtering component is inserted and installed inside the tank body (21) from the outer wall of one side of the tank body (21), and the locking component pushes the inserted filtering component downwards at the moment so as to lock and fix the filtering component, thereby completing quick disassembly and replacement of the filtering component.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN209242970U (en) * | 2018-11-06 | 2019-08-13 | 希施生物科技（上海）有限公司 | A kind of peptide purification preparation facilities |
| CN212882339U (en) * | 2020-07-14 | 2021-04-06 | 湖北强耀生物科技有限公司 | Polypeptide purification preparation facilities |
| WO2021135149A1 (en) * | 2019-12-31 | 2021-07-08 | 江苏高科制药设备有限公司 | Carbon dioxide supercritical extraction method for pharmaceutical use |
| CN114100195A (en) * | 2021-11-10 | 2022-03-01 | 邵杜娟 | Polypeptide separation and purification system |
| WO2023173672A1 (en) * | 2022-03-14 | 2023-09-21 | 华能酒泉风电有限责任公司 | Wind turbine gearbox oil changing device and use method thereof |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN209242970U (en) * | 2018-11-06 | 2019-08-13 | 希施生物科技（上海）有限公司 | A kind of peptide purification preparation facilities |
| WO2021135149A1 (en) * | 2019-12-31 | 2021-07-08 | 江苏高科制药设备有限公司 | Carbon dioxide supercritical extraction method for pharmaceutical use |
| CN212882339U (en) * | 2020-07-14 | 2021-04-06 | 湖北强耀生物科技有限公司 | Polypeptide purification preparation facilities |
| CN114100195A (en) * | 2021-11-10 | 2022-03-01 | 邵杜娟 | Polypeptide separation and purification system |
| WO2023173672A1 (en) * | 2022-03-14 | 2023-09-21 | 华能酒泉风电有限责任公司 | Wind turbine gearbox oil changing device and use method thereof |
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