WO2021135149A1

WO2021135149A1 - Carbon dioxide supercritical extraction method for pharmaceutical use

Info

Publication number: WO2021135149A1
Application number: PCT/CN2020/101532
Authority: WO
Inventors: 沈立华
Original assignee: 江苏高科制药设备有限公司
Priority date: 2019-12-31
Filing date: 2020-07-13
Publication date: 2021-07-08
Also published as: CN111013192A; CN111013192B

Abstract

The present invention belongs to the field of pharmaceutical apparatuses, and disclosed is a carbon dioxide supercritical extraction method for pharmaceutical use. A carbon dioxide supercritical extraction method for pharmaceutical use, comprising an extraction tank, a carbon dioxide storage tank, a medicine storage tank, a pressurizing device, and a separation tank, and comprising the following step: S1, delivering carbon dioxide into the extraction tank from the carbon dioxide storage tank, and delivering a medical solution into the extraction tank from the medicine storage tank. The present invention can achieve the recovery of gaseous carbon dioxide under normal temperature and normal pressure, simplifying the extraction process and the apparatus constitution, reducing costs; a first shell is used to spray a medical solution to increase the speed of mixing the medical solution with supercritical carbon dioxide, increasing the extraction efficiency; moreover, wing plates are provided in the separation tank to strike the falling mixture, so that gas and liquid are completely separated, and a reciprocating mechanism is used to drive the two wing plates to flap back and forth, improving the striking effect.

Description

Method for supercritical extraction of carbon dioxide for pharmacy

Technical field

The invention relates to the field of pharmaceutical equipment, and more specifically, to a method for supercritical extraction of carbon dioxide for pharmaceuticals.

Background technique

The principle of the supercritical carbon dioxide extraction and separation process is to use supercritical carbon dioxide to have a special dissolving effect on some special natural products, and to use the relationship between the dissolution capacity of supercritical carbon dioxide and its density, that is, the influence of pressure and temperature on the dissolution capacity of supercritical carbon dioxide. ongoing. In the supercritical state, the supercritical carbon dioxide is contacted with the substance to be separated to selectively extract components with different polarity, boiling point, and molecular weight. Of course, the extraction corresponding to each pressure range is obtained. The substance can not be a single substance, but the conditions can be controlled to obtain the best ratio of the mixed components, and then the supercritical fluid can be turned into an ordinary gas by means of decompression and heating, and the extracted substance can be completely or basically precipitated, so as to achieve separation and purification. purpose.

In the pharmaceutical process, supercritical carbon dioxide is generally used to extract drugs. However, the current extraction process is to recover the carbon dioxide in a liquid state, which causes the equipment composition to be more complicated, the operation difficulty increases, the cost also increases, and the extraction in the device Most of the tanks still allow the supercritical carbon dioxide and the drug to be naturally mixed, so that the extraction time is longer, which affects the production efficiency. In addition, the separation tank used to separate the extract has a relatively simple structure, mainly using curved pipes for gas and liquid separation and separation. Not thorough enough, the process is slower.

Summary of the invention

1. Technical problems to be solved

In view of the problems in the prior art, the purpose of the present invention is to provide a method for supercritical extraction of carbon dioxide for pharmaceuticals, which can realize the recovery of gaseous carbon dioxide under normal temperature and pressure, simplify the extraction process and equipment composition, reduce costs, and use the conventional The first shell is used to sprinkle the liquid medicine to speed up the mixing speed with supercritical carbon dioxide and improve the extraction efficiency. In addition, a wing plate is also provided in the separation tank to hit the fallen mixture, so that the gas-liquid separation is completely separated, and at the same time Use the reciprocating mechanism to drive the two wings to instigate back and forth to improve the effect of hitting.

2. Technical solution

To solve the above problems, the present invention adopts the following technical solutions.

A method for supercritical extraction of carbon dioxide for pharmaceuticals, including an extraction tank, a carbon dioxide storage tank, a medicine storage tank, a pressurizer, and a separation tank, and includes the following steps:

S1, the carbon dioxide storage tank sends carbon dioxide to the extraction tank, and the chemical storage tank sends the liquid medicine to the extraction tank;

S2: The pressurizer pressurizes the extraction tank, and cooperates with the temperature control device of the extraction tank to make the carbon dioxide in the extraction tank reach a supercritical state, and the supercritical carbon dioxide extracts the liquid medicine;

S3, the extracted mixed liquid enters the separation tank at normal temperature and pressure. Under normal temperature and pressure conditions, carbon dioxide is a gas and is easily separated from the liquid medicine. The gaseous carbon dioxide is collected and returned to the carbon dioxide storage tank. Recycling.

Further, a carbon dioxide injection pump is installed between the carbon dioxide storage tank and the extraction tank, an air extractor is installed between the carbon dioxide storage tank and the separation tank, the carbon dioxide injection pump speeds up the injection speed, and the air extractor speeds up the recovery speed. .

Further, a plurality of first fixing plates are fixedly connected to the inner wall of the upper end of the extraction tank, a motor is installed on the side wall of each of the first fixing plates, and the output end of the motor is connected with a gear. The side walls of a fixed plate are provided with first sliding grooves, and a sliding plate is slidably connected to the first sliding groove, and the upper side side wall of the sliding plate is fixedly connected with a rack meshing with a gear, and each of the first sliding grooves The lower end of the fixed plate is fixedly connected with a bottom plate, and the upper end of the bottom plate is fixedly connected with two air springs. The lower end of the sliding plate is fixedly connected with a vertical suspension rod, and the suspension rod is arranged between the two air springs. The boom is arranged through the bottom plate, and the lower end of the boom is fixedly connected with a first housing, the upper end of the first housing is provided with an opening, and the side wall of the first housing is provided with a plurality of first leakage holes. When a shell moves down, the liquid medicine is scooped up, and when it moves up, the liquid medicine is spilled from the first leak to form a trickle, which speeds up the mixing with the supercritical carbon dioxide and improves the extraction efficiency.

Further, the opening includes two arc-shaped openings, and the two arc-shaped openings are respectively arranged on both sides of the boom, and the liquid medicine enters the inside of the first housing through the two arc-shaped openings.

Further, the arc length occupied by the teeth of the gear is half of its circumference. When the teeth on the gear mesh with the rack, the first housing moves upward, and when the teeth are separated from the rack, the first housing falls. As the gear continues to rotate, the first housing reciprocates up and down.

Further, a liquid inlet pipe is communicated with the separation tank, and a separation pipe is communicated with the liquid inlet pipe, a second housing is communicated with the lower end of the separation pipe, and the lower end side wall of the second housing is provided with a plurality of The second leakage hole, the inner wall of the lower end of the separation tank is fixedly connected with a second fixing plate, and the lower end of the second fixing plate is installed with a motor, and the output end of the motor is connected with a turntable, and the side wall of the second fixing plate is opened There is a second sliding groove, and a push block is slidably connected in the second sliding groove, and the side wall of the second fixed plate is rotatably connected with two symmetrically arranged wings, and the two wings are arranged in the push block, so A connecting rod is rotatably connected between the turntable and the push block. The rotation of the turntable makes the connecting rod drive the push block to reciprocate, and the push block pushes the two wing plates back and forth, so that the two wing plates are stirred like wings to achieve the effect of the mixture. Hit.

Further, the push block includes a push plate and two clamping blocks, the two clamping blocks are symmetrically arranged, and the distance between the two clamping blocks is greater than the thickness of the wing plate, and the wing plate is located between the two clamping blocks , The clamping block pushes the wing plate back and forth to stir up.

Further, the shape of the separation tube is wavy, and the inner wall of the separation tube is fixedly connected with a plurality of sets of shifting plates, and each group of two shifting plates are arranged opposite to each other, and the shifting plates cause the mixture to scatter and improve the separation effect.

Further, the inner wall of the lower end of the first housing is inclined and inclined to both sides, and the inclined bottom wall facilitates the falling of the mixture.

Further, the outer cover of the motor is provided with a protective cover, and the outer surface of the protective cover is coated with anti-corrosion material, and the protective cover protects the motor from being corroded by the chemical liquid.

3. Beneficial effects

Compared with the prior art, the advantages of the present invention are:

(1) This solution can realize the recovery of gaseous carbon dioxide under normal temperature and pressure, simplify the extraction process and equipment composition, reduce costs, and use the first shell to sprinkle liquid medicine to speed up the mixing speed of supercritical carbon dioxide and improve extraction. The separation tank is also equipped with wings to hit the fallen mixture to make the gas-liquid separation completely separate. At the same time, the reciprocating mechanism is used to drive the two wings to stir back and forth to improve the hitting effect.

(2) A carbon dioxide injection pump is installed between the carbon dioxide storage tank and the extraction tank, and an air extractor is installed between the carbon dioxide storage tank and the separation tank. The carbon dioxide injection pump speeds up the injection speed and the air extractor speeds up the recovery speed.

(3) A plurality of first fixing plates are fixedly connected to the inner wall of the upper end of the extraction tank, the side wall of each first fixing plate is equipped with a motor, and the output end of the motor is connected with a gear, and the side wall of each first fixing plate All are provided with first sliding grooves, and a sliding plate is slidably connected to the first sliding groove, a side wall of the upper end of the sliding plate is fixedly connected with a rack meshing with a gear, and the lower end of each first fixing plate is fixedly connected with a bottom plate, And the upper end of the bottom plate is fixedly connected with two air springs, the lower end of the slide plate is fixedly connected with a vertical suspension rod, and the suspension rod is arranged between the two air springs, the suspension rod is arranged through the bottom plate, and the lower end of the suspension rod is fixedly connected There is a first shell, the upper end of the first shell is provided with an opening, and the side wall of the first shell is provided with a plurality of first leakage holes. When the first shell moves down, the liquid medicine is scooped up and moved up. At this time, the liquid medicine is sprinkled from the first leak to form a trickle, so that the shell speeds up the mixing with the supercritical carbon dioxide and improves the extraction efficiency.

(4) The opening includes two arc-shaped openings, and the two arc-shaped openings are respectively arranged on both sides of the boom, and the liquid medicine enters the inside of the first housing through the two arc-shaped openings.

(5) The arc length occupied by the teeth of the gear is half of its circumference. When the teeth on the gear mesh with the rack, the first housing moves upward, and when the teeth are separated from the rack, the first housing falls. The continuous rotation of the gear causes the first housing to reciprocate up and down.

(6) The separation tank is connected with a liquid inlet pipe, and the liquid inlet pipe is connected with a separation pipe. The lower end of the separation pipe is communicated with a second casing, and the lower end side wall of the second casing is provided with a plurality of second leakage holes , The inner wall of the lower end of the separation tank is fixedly connected with a second fixing plate, and the lower end of the second fixing plate is installed with a motor, and the output end of the motor is connected with a turntable, the side wall of the second fixing plate is provided with a second chute, and A push block is slidably connected to the two sliding grooves, two symmetrically arranged wings are rotatably connected to the side wall of the second fixed plate, and the two wings are arranged in the push block, and a connecting rod is rotatably connected between the turntable and the push block. , The rotation of the turntable makes the connecting rod drive the push block to reciprocate, and the push block pushes the two wing plates back and forth, so that the two wing plates are stirred up like wings to achieve a blow to the mixture.

(7) The push block includes a push plate and two clamping blocks. The two clamping blocks are arranged symmetrically, and the distance between the two clamping blocks is greater than the thickness of the wing plate. The wing plate is between the two clamping blocks, and the clamping blocks go back and forth. Promote the wings to stir up.

(8) The shape of the separation tube is wavy, and the inner wall of the separation tube is fixedly connected with multiple sets of shifting plates, and each group of two shifting plates are arranged opposite to each other, the shifting plates allow the mixture to scatter and improve the separation effect.

(9) The inner wall of the lower end of the first shell is inclined and inclined to both sides, and the inclined bottom wall is convenient for the mixture to fall.

(10) The outer cover of the motor is provided with a protective cover, and the outer surface of the protective cover is coated with anti-corrosion material, and the protective cover protects the motor from corrosion by the chemical liquid.

Description of the drawings

Figure 1 is a schematic diagram of the three-dimensional structure of the present invention;

Figure 2 is a schematic sectional view of the structure of the extraction tank of the present invention;

Figure 3 is a schematic sectional view of the structure of the separation tank of the present invention;

4 is a schematic diagram of the three-dimensional structure of the first housing of the present invention;

Figure 5 is a schematic diagram of the structure at A in Figure 3;

Fig. 6 is a schematic diagram of the front view of the push block of the present invention.

Explanation of labels in the figure:

1 extraction tank, 2 carbon dioxide storage tank, 3 storage tank, 4 pressurizer, 5 separation tank, 6 first fixed plate, 7 gear, 8 first chute, 9 sliding plate, 10 bottom plate, 11 air spring, 12 hoist Rod, 13 first shell, 14 opening, 15 first leak, 16 inlet tube, 17 separation tube, 18 dial plate, 19 second shell, 20 second leak, 21 second fixing plate, 22 Two chutes, 23 push blocks, 2301 push plates, 2301 clamp blocks, 24 wings, 25 turntables, 26 connecting rods, 27 racks, 28 carbon dioxide injection pumps, and 29 air extraction machines.

Detailed ways

The following will combine the drawings in the embodiments of the present invention; the technical solutions in the embodiments of the present invention will be described clearly and completely; obviously; the described embodiments are only a part of the embodiments of the present invention; not all the embodiments are based on The embodiments of the present invention; all other embodiments obtained by a person of ordinary skill in the art without creative work; all belong to the protection scope of the present invention.

In the description of the present invention, it should be noted that the directions or positional relationships indicated by the terms "upper", "lower", "inner", "outer", and "top/bottom" are based on the directions shown in the drawings. The or positional relationship is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the pointed device or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation of the present invention. In addition, the terms "first" and "second" are only used for descriptive purposes, and cannot be understood as indicating or implying relative importance.

In the description of the present invention, it should be noted that the terms "installed", "provided with", "sleeved/connected", "connected", etc., should be interpreted broadly, such as " "Connection" can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium, and it can be inside two components.的连接。 Connectivity. For those of ordinary skill in the art, the specific meanings of the above-mentioned terms in the present invention can be understood in specific situations.

Example 1:

Refer to Figure 1-6, a method for supercritical extraction of carbon dioxide for pharmaceuticals, including an extraction tank 1, a carbon dioxide storage tank 2, a medicine storage tank 3, a pressurizer 4, and a separation tank 5, including the following steps:

S1, the carbon dioxide storage tank 2 sends carbon dioxide to the extraction tank 1, and the chemical storage tank 3 sends the liquid medicine to the extraction tank 1;

S2: The pressurizer 4 pressurizes the extraction tank 1, and cooperates with the temperature control device of the extraction tank 1 to make the carbon dioxide in the extraction tank 1 reach a supercritical state, and the supercritical carbon dioxide extracts the liquid medicine;

S3, the extracted mixed liquid enters the separation tank 5 at normal temperature and pressure. Under normal temperature and pressure conditions, carbon dioxide is a gas and is easily separated from the liquid medicine. The gaseous carbon dioxide is collected and returned to the carbon dioxide storage tank 2 , To achieve recycling.

A carbon dioxide injection pump 28 is installed between the carbon dioxide storage tank 2 and the extraction tank 1, and an air extractor 29 is installed between the carbon dioxide storage tank 2 and the separation tank 5. The carbon dioxide injection pump 28 speeds up the injection speed, and the air extractor 29 speeds up the recovery. speed;

A plurality of first fixing plates 6 are fixedly connected to the inner wall of the upper end of the extraction tank 1, and a motor is installed on the side wall of each first fixing plate 6 (the internal structure of the motor and its working principle are well-known to those skilled in the art, and will not be described here. Too much repetition), the outer cover of the motor is provided with a protective cover, and the outer surface of the protective cover is coated with anti-corrosion material, the protective cover protects the motor from corrosion by the chemical liquid, and the output end of the motor is connected with the gear 7 and the gear 7 The arc length occupied by the teeth is half of its circumference. When the teeth on the gear 7 mesh with the rack 27, the first housing 13 moves upward. When the teeth are separated from the rack 27, the first housing 13 falls. With the continuous rotation of the gear 7, the first housing 13 reciprocates up and down. The side wall of each first fixed plate 6 is provided with a first slide groove 8, and the first slide groove 8 is slidably connected with a sliding plate 9 The side wall of the upper end is fixedly connected with a rack 27 that meshes with the gear 7, the lower end of each first fixing plate 6 is fixedly connected with a bottom plate 10, and the upper end of the bottom plate 10 is fixedly connected with two air springs 11, the sliding plate 9 The lower end is fixedly connected with a vertically arranged boom 12, and the boom 12 is arranged between the two air springs 11, the boom 12 is arranged through the bottom plate 10, and the lower end of the boom 12 is fixedly connected with the first housing 13. The inner wall of the lower end of a shell 13 is inclined and inclined to both sides. The inclined bottom wall facilitates the falling of the mixture. The upper end of the first shell 13 is provided with an opening 14 which includes two arc-shaped openings and two arcs. Shaped openings are respectively arranged on both sides of the boom 12, the liquid medicine enters the inside of the first housing 13 through two arc-shaped openings, and the side walls of the first housing 13 are provided with a plurality of first leakage holes 15, the first Scoop up the liquid medicine when the shell 13 moves down, and when it moves up, the liquid medicine is spilled from the first leak hole 15 to form a trickle, which speeds up the mixing with the supercritical carbon dioxide and improves the extraction efficiency;

A liquid inlet pipe 16 is connected to the separation tank 5, and a separation pipe 17 is communicated on the liquid inlet pipe 16. The shape of the separation pipe 17 is wavy, and the inner wall of the separation pipe 17 is fixedly connected with a plurality of sets of dial plates 18, and each set of two The two shift plates 18 are arranged opposite to each other. The shift plates 18 spread the mixture and improve the separation effect. The lower end of the separation tube 17 is connected with a second housing 19, and the lower end side wall of the second housing 19 is provided with a plurality of second Leak hole 20, the inner wall of the lower end of the separation tank 5 is fixedly connected with a second fixing plate 21, and the lower end of the second fixing plate 21 is installed with a motor, and the output end of the motor is connected with a turntable 25, and the side wall of the second fixing plate 21 is provided There is a second chute 22, and a push block 23 is slidably connected to the second chute 22. The push block 23 includes a push plate 2301 and two clamping blocks 2302. The two clamping blocks 2302 are symmetrically arranged, and the two clamping blocks 2302 The distance between the wing plate 24 is greater than the thickness of the wing plate 24. The wing plate 24 is between the two clamping blocks 2302. The clamping block 2302 pushes the wing plate 24 back and forth to stir up. The side wall of the second fixing plate 21 is rotationally connected with two symmetrically arranged The wing plate 24 and the two wing plates 24 are arranged in the push block 23. A connecting rod 26 is rotatably connected between the turntable 25 and the push block 23. The rotation of the turntable 25 causes the connecting rod 26 to drive the push block 23 to reciprocate, and the push block 23 Push the two wing plates 24 back and forth, so that the two wing plates 24 inflame like wings to achieve a blow to the mixture.

When the extraction tank 1 of this device is working, the motor drives the gear 7 to rotate. When the teeth on the gear 7 mesh with the rack 27, the first housing 13 moves upward, and when the teeth are separated from the rack 27, the first housing 13 falls , With the continuous rotation of the gear 7, the first housing 13 reciprocates up and down. When the first housing 13 moves down, the liquid medicine is scooped up, and when it moves up, the liquid medicine is spilled from the first leak 15 to form a trickle. This speeds up the mixing with supercritical carbon dioxide and improves the extraction efficiency. The air spring 11 acts as a buffer for the mounting plate 9 to avoid too much noise. When the separation tank 5 is working, the motor drives the turntable 25 to rotate, and the disk 25 rotates. The connecting rod 26 drives the push block 23 to reciprocate, and the push block 23 pushes the two wing plates 24 back and forth, so that the two wing plates 24 are fanned like wings to achieve a blow to the mixture. It can realize the recovery of gaseous carbon dioxide under normal temperature and pressure, simplify the extraction process and equipment composition, reduce costs, and use the first shell to sprinkle liquid medicine to speed up the mixing speed of supercritical carbon dioxide and improve the extraction efficiency. A wing plate is also provided in the separation tank to strike the fallen mixture so as to separate the gas and liquid completely. At the same time, the reciprocating mechanism is used to drive the two wing plates to stir back and forth to improve the effect of striking.

The above; is only the preferred specific implementation of the present invention; but the scope of protection of the present invention is not limited to this; any person familiar with the technical field within the technical scope disclosed in the present invention; according to the technical solution of the present invention The improvement concept and the equivalent replacement or change shall be included in the protection scope of the present invention.

Claims

A method for supercritical extraction of carbon dioxide for pharmaceuticals, comprising an extraction tank (1), a carbon dioxide storage tank (2), a medicine storage tank (3), a pressurizer (4) and a separation tank (5), and is characterized in that: step:

S1, the carbon dioxide storage tank (2) sends carbon dioxide to the extraction tank (1), and the medicine storage tank (3) sends the liquid medicine to the extraction tank (1);

S2, the pressurizer (4) pressurizes the extraction tank (1), and cooperates with the temperature control device of the extraction tank (1) to make the carbon dioxide in the extraction tank (1) reach a supercritical state, and the supercritical carbon dioxide can affect the liquid medicine. Perform extraction

S3, the extracted mixed liquid enters the separation tank (5) at normal temperature and pressure. Under normal temperature and pressure conditions, carbon dioxide is a gas and is easily separated from the liquid medicine. The gaseous carbon dioxide is collected and returned to the carbon dioxide storage tank. (2) In, realize recycling.
The method for supercritical extraction of carbon dioxide for pharmaceutical use according to claim 1, characterized in that: a carbon dioxide injection pump (28) is installed between the carbon dioxide storage tank (2) and the extraction tank (1), and the carbon dioxide storage An air extractor (29) is installed between the tank (2) and the separation tank (5).
The method for supercritical carbon dioxide extraction for pharmaceutical use according to claim 1, characterized in that: the upper inner wall of the extraction tank (1) is fixedly connected with a plurality of first fixing plates (6), each of the first fixing plates (6) The side walls of the fixed plates (6) are equipped with motors, and the output ends of the motors are connected with gears (7), and the side walls of each of the first fixed plates (6) are provided with first sliding grooves (8), And a sliding plate (9) is slidably connected to the first sliding groove (8), and a rack (27) meshing with a gear (7) is fixedly connected to the side wall of the upper end of the sliding plate (9). The lower end of a fixed plate (6) is fixedly connected with a bottom plate (10), and the upper end of the bottom plate (10) is fixedly connected with two air springs (11), and the lower end of the sliding plate (9) is fixedly connected with a vertically arranged The suspension rod (12), and the suspension rod (12) is arranged between the two air springs (11), the suspension rod (12) is arranged through the bottom plate (10), and the lower end of the suspension rod (12) is fixedly connected with the first A housing (13), the upper end of the first housing (13) is provided with an opening (14), and the side wall of the first housing (13) is provided with a plurality of first leakage holes (15).
The method for supercritical extraction of carbon dioxide for pharmaceutical use according to claim 3, characterized in that the opening (14) comprises two arc-shaped openings, and the two arc-shaped openings are respectively located on both sides of the boom (12) Set up.
The method for supercritical extraction of carbon dioxide for pharmaceutical use according to claim 3, characterized in that the arc length occupied by the teeth of the gear (7) is half of its circumference.
The method for supercritical extraction of carbon dioxide for pharmaceutical use according to claim 1, wherein the separation tank (5) is connected with a liquid inlet pipe (16), and the liquid inlet pipe (16) is connected with a separating pipe (17), the lower end of the separation pipe (17) is communicated with a second housing (19), and the lower end side wall of the second housing (19) is provided with a plurality of second leakage holes (20), the separation The inner wall of the lower end of the tank (5) is fixedly connected with a second fixing plate (21), and a motor is installed at the lower end of the second fixing plate (21), and the output end of the motor is connected with a turntable (25), the second fixing plate The side wall of (21) is provided with a second slide groove (22), and the second slide groove (22) is slidably connected with a push block (23), and the side wall of the second fixed plate (21) is rotatably connected with two Two wing plates (24) are symmetrically arranged, and two wing plates (24) are arranged in the push block (23), and a connecting rod (26) is rotatably connected between the turntable (25) and the push block (23).
The method for supercritical carbon dioxide extraction for pharmaceutical use according to claim 6, characterized in that: the pushing block (23) comprises a pushing plate (2301) and two clamping blocks (2302), and the two clamping blocks ( 2302) is symmetrically arranged, and the distance between the two clamping blocks (2302) is greater than the thickness of the wing plate (24).
The method for supercritical extraction of carbon dioxide for pharmaceutical use according to claim 6, characterized in that: the shape of the separation tube (17) is wavy, and the inner wall of the separation tube (17) is fixedly connected with a plurality of sets of shift plates (18), and each group of two shift plates (18) are arranged oppositely.
The method for supercritical extraction of carbon dioxide for pharmaceutical use according to claim 3, characterized in that the inner wall of the lower end of the first shell (13) is inclined and inclined to both sides.
The method for supercritical extraction of carbon dioxide for pharmaceutical use according to claim 3, wherein the outer cover of the motor is provided with a protective cover, and the outer surface of the protective cover is coated with anti-corrosion material.