CN117323308A - Vitamin C sodium capsule and preparation method thereof - Google Patents
Vitamin C sodium capsule and preparation method thereof Download PDFInfo
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- CN117323308A CN117323308A CN202311519810.3A CN202311519810A CN117323308A CN 117323308 A CN117323308 A CN 117323308A CN 202311519810 A CN202311519810 A CN 202311519810A CN 117323308 A CN117323308 A CN 117323308A
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- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 title claims abstract description 78
- 239000002775 capsule Substances 0.000 title claims abstract description 47
- 238000002360 preparation method Methods 0.000 title claims abstract description 20
- 239000003094 microcapsule Substances 0.000 claims abstract description 48
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims abstract description 27
- 239000000787 lecithin Substances 0.000 claims abstract description 27
- 235000010445 lecithin Nutrition 0.000 claims abstract description 27
- 229940067606 lecithin Drugs 0.000 claims abstract description 27
- 229920001661 Chitosan Polymers 0.000 claims abstract description 25
- 229920002774 Maltodextrin Polymers 0.000 claims abstract description 24
- 239000005913 Maltodextrin Substances 0.000 claims abstract description 24
- 229940035034 maltodextrin Drugs 0.000 claims abstract description 24
- 239000000839 emulsion Substances 0.000 claims abstract description 23
- 238000000034 method Methods 0.000 claims abstract description 23
- 238000001694 spray drying Methods 0.000 claims abstract description 21
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims abstract description 18
- 229920000053 polysorbate 80 Polymers 0.000 claims abstract description 18
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 claims abstract description 15
- 235000010378 sodium ascorbate Nutrition 0.000 claims abstract description 15
- 229960005055 sodium ascorbate Drugs 0.000 claims abstract description 15
- 239000011162 core material Substances 0.000 claims abstract description 14
- 238000003756 stirring Methods 0.000 claims abstract description 13
- 238000010008 shearing Methods 0.000 claims abstract description 7
- 239000007921 spray Substances 0.000 claims abstract description 6
- 238000002156 mixing Methods 0.000 claims abstract description 4
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 46
- 239000000243 solution Substances 0.000 claims description 45
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 20
- 229930003268 Vitamin C Natural products 0.000 claims description 20
- 235000019154 vitamin C Nutrition 0.000 claims description 20
- 239000011718 vitamin C Substances 0.000 claims description 20
- 230000001804 emulsifying effect Effects 0.000 claims description 14
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 6
- 239000007853 buffer solution Substances 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 229910052708 sodium Inorganic materials 0.000 claims description 6
- 239000011734 sodium Substances 0.000 claims description 6
- 238000000265 homogenisation Methods 0.000 claims description 5
- BHZOKUMUHVTPBX-UHFFFAOYSA-M sodium acetic acid acetate Chemical compound [Na+].CC(O)=O.CC([O-])=O BHZOKUMUHVTPBX-UHFFFAOYSA-M 0.000 claims description 5
- 239000000872 buffer Substances 0.000 claims description 2
- 239000002131 composite material Substances 0.000 abstract description 12
- 239000003995 emulsifying agent Substances 0.000 abstract description 12
- 239000000463 material Substances 0.000 abstract description 8
- 230000014759 maintenance of location Effects 0.000 abstract description 7
- 230000002035 prolonged effect Effects 0.000 abstract description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 238000001035 drying Methods 0.000 description 6
- 239000003814 drug Substances 0.000 description 5
- 108010052164 Sodium Channels Proteins 0.000 description 4
- 102000018674 Sodium Channels Human genes 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 229920000136 polysorbate Polymers 0.000 description 4
- 206010048031 Wound dehiscence Diseases 0.000 description 3
- 235000010323 ascorbic acid Nutrition 0.000 description 3
- 239000011668 ascorbic acid Substances 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 206010039966 Senile dementia Diseases 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 229940072107 ascorbate Drugs 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 229950008882 polysorbate Drugs 0.000 description 2
- 238000004321 preservation Methods 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 150000003254 radicals Chemical class 0.000 description 2
- 230000029663 wound healing Effects 0.000 description 2
- 208000024827 Alzheimer disease Diseases 0.000 description 1
- 229920002498 Beta-glucan Polymers 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 238000006065 biodegradation reaction Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 230000006196 deacetylation Effects 0.000 description 1
- 238000003381 deacetylation reaction Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 235000003084 food emulsifier Nutrition 0.000 description 1
- 230000027119 gastric acid secretion Effects 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- -1 lipid peroxide Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000001000 micrograph Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000007348 radical reaction Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000011506 response to oxidative stress Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
Abstract
The invention provides a vitamin C sodium capsule and a preparation method thereof, and relates to the technical field of vitamin C sodium capsules. A preparation method of a vitamin C sodium capsule comprises the steps of S1, preparing lecithin solution; s2, putting the sodium ascorbate and tween-80 into lecithin solution, mixing, and carrying out high-speed shearing and stirring to obtain core material solution; s3, preparing chitosan solution; s4, preparing maltodextrin solution; s5, preparing microcapsule emulsion; s6, spray drying the microcapsule emulsion by using a spray dryer to obtain the vitamin C sodium microcapsule. According to the vitamin C sodium capsule and the preparation method thereof, chitosan and maltodextrin are used as composite wall materials of the vitamin C sodium microcapsule, lecithin and tween-80 are selected to prepare a composite emulsifier, spray drying process conditions are optimized, the prepared vitamin C sodium capsule has high embedding rate and retention rate, and meanwhile, the moisture content in the vitamin C sodium microcapsule is low, so that the vitamin C sodium capsule has stable performance, and the shelf life of a product is prolonged.
Description
Technical Field
The invention relates to the technical field of sodium vitamin C capsules, in particular to a sodium vitamin C capsule and a preparation method thereof.
Background
Sodium ascorbate (L-AscorbicAcidSodiumSalt) is a vitamin C enhancer widely used at home and abroad. Vitamin C has been replaced gradually, but besides the United states, italy and Switzerland, no sodium ascorbate preparation is available in China for people to use as a medicine. Vitamin C is a clinical basic common medicine and is widely applied to the prevention and treatment of various diseases. Because vitamin C has larger acidity (the pH value of 4% solution is 2.4), clinical symptoms such as gastric acid secretion increase are not suitable for long-term use, and the vitamin C is used with some medicines for treating ulcers at present; in addition, many drugs cannot be used together with acidic vitamin C. The existing clinical application of vitamin C has the disadvantages of increased indication, increased dosage and long service life, ensures safe administration for expanding the application range of the vitamin C, and is urgently needed to develop a vitamin C sodium capsule with a pH value close to neutral so as to replace the oral preparation of the vitamin C to be applied clinically.
Aiming at the problems, the inventor discloses an invention patent with application number 200310111592.6 and the invention name of vitamin C sodium capsule, and discloses a vitamin C sodium capsule which has stable product performance, good moisture retention, nearly neutral PH value and wide application range and can replace an oral preparation of vitamin C in clinical application. However, in the subsequent production process, the vitamin C sodium capsule and the preparation process thereof cannot ensure the stability of the performance for a long time, and the shelf life of the product cannot reach the expectancy. In order to solve the problem, the present inventors provide a sodium vitamin C capsule and a preparation method thereof.
Disclosure of Invention
Aiming at the technical problems that the existing vitamin C sodium capsule cannot guarantee the stability of the performance for a long time and the shelf life of the product cannot reach the expected, the invention provides the vitamin C sodium capsule and the preparation method thereof, wherein chitosan and maltodextrin are used as the composite wall material of the vitamin C sodium microcapsule, lecithin and tween-80 are selected to prepare a composite emulsifier, the spray drying process condition is optimized, the prepared vitamin C sodium capsule has higher embedding rate and retention rate, and meanwhile, the moisture content in the vitamin C sodium microcapsule is low, so that the vitamin C sodium capsule is favorable for preserving the product, the performance of the vitamin C sodium capsule is stable, and the shelf life of the product is prolonged.
Therefore, the technical scheme of the invention is that the preparation method of the vitamin C sodium capsule comprises the following specific steps:
s1, preparing a lecithin solution, and adding lecithin into a buffer solution to prepare the lecithin solution;
s2, preparing a core material solution, putting sodium ascorbate and tween-80 into a lecithin solution, mixing, and carrying out high-speed shearing and stirring by a high-speed emulsifying and dispersing machine to obtain the core material solution;
s3, preparing a chitosan solution, and preparing the chitosan solution in a chitosan buffer solution;
s4, preparing a maltodextrin solution, and adding maltodextrin into the buffer solution to prepare the maltodextrin solution;
s5, preparing microcapsule emulsion, namely adding chitosan solution into core material solution while stirring, adding maltodextrin solution while stirring, performing high-speed shearing and stirring by using a high-speed emulsifying and dispersing machine, and performing high-pressure homogenization by using a homogenizer to obtain microcapsule emulsion;
s6, spray drying the microcapsule emulsion by using a spray dryer to obtain the vitamin C sodium microcapsule.
Preferably, the buffer is a solution of sodium acetate-acetic acid at a concentration of 0.1mo/L and a pH of 3.0.
Preferably, the mass ratio of lecithin to tween-80 is 2:1.
Preferably, when preparing the core material solution, the high-speed emulsifying and dispersing machine is set to 10000-15000r/min, and the working time is 3-5min.
Preferably, in preparing the microcapsule emulsion, a high-speed emulsifying disperser is arranged as follows
10000-15000r/min, and the working time is 3-5min.
Preferably, when preparing microcapsule emulsion, the homogenizer is set to 35-40Mpa, and the homogenization times are 2-3 times.
Preferably, the air inlet temperature of the spray dryer is 185-190 ℃ and the air outlet temperature is 80-85 ℃.
The vitamin C sodium capsule is prepared by adopting the method and comprises the following raw materials in parts by weight: 6 parts of chitosan, 100 parts of maltodextrin, 65 parts of sodium ascorbate, 12 parts of lecithin and 6 parts of tween-80.
The vitamin C sodium capsule and the preparation method thereof have the beneficial effects that the chitosan and the maltodextrin are used as the composite wall material of the vitamin C sodium microcapsule, so that the vitamin C sodium capsule has good film forming property, good mechanical stability, good biocompatibility and increased strength and compactness of the microcapsule film, and the raw materials are easy to obtain and low in price; the lecithin and the Tween-80 are selected to prepare the composite emulsifier, spray drying process conditions are optimized, the air inlet temperature is 185-190 ℃, and the spray drying method with the air outlet temperature of 80-85 ℃ is adopted, so that the prepared vitamin C sodium capsule has higher embedding rate and retention rate, and meanwhile, the moisture content in the vitamin C sodium microcapsule is low, thereby being beneficial to the preservation of products, ensuring the stability of the performance of the vitamin C sodium capsule and prolonging the shelf life of the products.
Drawings
Fig. 1 is a flow chart of a method for preparing a sodium vitamin C capsule according to the present invention.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
As shown in fig. 1, the invention provides a preparation method of a vitamin C sodium capsule, which comprises the following specific steps:
s1, preparing a lecithin solution, and adding lecithin into 0.1mo/L acetic acid-sodium acetate solution with pH of 3.0 to prepare the lecithin solution.
S2, preparing a core material solution, putting the sodium ascorbate and the tween-80 into the lecithin solution, mixing, and carrying out high-speed shearing and stirring by a high-speed emulsifying and dispersing machine to obtain the core material solution. The high-speed emulsifying and dispersing machine is set to 10000-15000r/min, and the working time is 3-5min.
S3, preparing a chitosan solution, and adding chitosan into an acetic acid-sodium acetate solution with the concentration of 0.1mo/L and the pH of 3.0 to prepare the chitosan solution.
S4, preparing a maltodextrin solution, and adding maltodextrin into a 0.1mo/L acetic acid-sodium acetate solution with the pH of 3.0 to prepare the maltodextrin solution.
The invention creatively takes chitosan and maltodextrin as composite wall materials of vitamin C sodium microcapsules, wherein the chitosan is a linear polymer with a similar cellulose structure, is an alkaline polysaccharide existing in nature, is a product of chitosan after deacetylation by a chemical method, has the structural formula of (1, 4) -2-amino-2-deoxidization-beta-glucan, has the characteristics of no toxicity, no smell and easy biodegradation, has good film forming property, good mechanical stability, good biocompatibility, certain excellent performances of antibiosis, tumor resistance and the like, is easy to obtain raw materials, is low in price, and is an ideal microcapsule wall material, and has great application potential in the field of controlled release medicines. Maltodextrin is a product of incomplete hydrolysis of starch, is a polysaccharide which is not sweet and has nutritional value, is not easy to absorb water, has low viscosity and good water solubility, has no surface activity and no emulsifying property, can be used as a filler to increase the strength and the compactness of a microcapsule membrane, and is a microcapsule wall material with higher cost performance.
S5, preparing microcapsule emulsion, adding the chitosan solution into the core material solution while stirring, adding the maltodextrin solution while stirring, performing high-speed shearing and stirring by using a high-speed emulsifying and dispersing machine, and performing high-pressure homogenization by using a homogenizer to obtain the microcapsule emulsion. The high-speed emulsifying and dispersing machine is set to 10000-15000r/min, and the working time is 3-5min. The homogenizer is set at 35-40Mpa, and the homogenizing times are 2-3 times.
When preparing microcapsule emulsion, it is often necessary to add an emulsifier to obtain emulsion with higher stability and better dispersion of core material; the emulsion has poor stability, and is unfavorable for the emulsion to be sprayed into small liquid drops and formed into a film by an atomizer, so that the core material cannot be fully embedded. The vitamin C sodium microcapsule emulsion belongs to oil-in-water solution, and oil-in-water type emulsifier should be selected to obtain emulsion with good stability, and the emulsifier has hydrophilic-lipophilic balance (HLB) of 7-18, and is suitable for use as oil-in-water (O/W) emulsifier.
The lecithin is a natural surfactant, has surface activity, and physiological activities of deferring senility, preventing cardiovascular and cerebrovascular diseases, strengthening brain and developing intelligence, preventing senile dementia, protecting liver and the like, and is widely used in various fields; tween is a commonly used food emulsifier, and because polysorbate molecules have more hydrophilic groups-polyoxyethylene groups, the polysorbate molecules have strong hydrophilicity, and the tween-80 is often used as an oil-in-water (O/W) type emulsifier, so that the tween-80 has stronger emulsifying property in the tween series.
According to the invention, lecithin and tween-80 are selected to prepare the composite emulsifier, and the inventor researches that when the mass ratio of the lecithin to the tween-80 is 2:1, namely the HLB value is 9.7, the emulsion with chitosan and maltodextrin as wall materials has the best emulsion stability, so that a stable emulsion can be obtained, and therefore, the mass ratio of the lecithin to the tween-80 in the composite emulsifier is 2:1.
In order to ensure that the vitamin C sodium microcapsule product has higher embedding rate and retention rate, and simultaneously considers the problems of the carrying capacity, the production cost and the like of the vitamin C sodium, the invention adopts the chitosan with the content of 0.6 percent, the maltodextrin with the content of 10 percent, the adding amount of the vitamin C sodium with the content of 6.5 percent and the using amount of the composite emulsifier with the content of 1.8 percent.
S6, spray drying the microcapsule emulsion by using a spray dryer to obtain the vitamin C sodium microcapsule.
In order to obtain a microcapsule product of good quality, it is also important to control the process conditions of spray drying. The temperature of the air inlet of the spray drying directly relates to the drying rate and the final moisture content of the microcapsule, and simultaneously influences the particle structure, hygroscopicity and the stability of thermosensitive components of the microcapsule, and the temperature of the air outlet of the spray drying influences the speed-down drying time, the microstructure of the surface, the flowability of the microcapsule and the like. The invention optimizes the spray drying process parameters.
The microcapsule spray drying process comprises two stages of constant-speed drying and deceleration drying, wherein the temperature of an air inlet of a spray drying tower influences the constant-speed drying process, and the temperature of an air outlet influences the deceleration drying process. After the spray drying process is optimized by the inventor, the process conditions of spray drying adopt an air inlet temperature of 185-190 ℃ and an air outlet temperature of 80-85 ℃. The embedding rate of the sodium ascorbate microcapsule prepared by the spray drying method can reach 91.15%, and the retention rate of sodium ascorbate can reach 94.05%.
The water content of the vitamin C sodium microcapsule prepared by the spray drying method is lower than 2.30%, and the water content of the vitamin C sodium microcapsule is low, so that the vitamin C sodium microcapsule is favorable for preserving products.
The scanning electron microscope image of the internal structure of the vitamin C sodium microcapsule prepared by the spray drying method shows that the particle size and the morphology of the vitamin C sodium microcapsule are uniform, the surface structure is complete, no crack, hole and fracture phenomenon is seen, the internal structure of the microcapsule is good, and the microcapsule has good embedding effect.
The invention provides a vitamin C sodium capsule which is prepared by adopting the preparation method of the vitamin C sodium capsule, and comprises the following raw materials in parts by weight: 6 parts of chitosan, 100 parts of maltodextrin, 65 parts of sodium ascorbate, 12 parts of lecithin and 6 parts of tween-80.
According to the vitamin C sodium capsule and the preparation method thereof, chitosan and maltodextrin are used as composite wall materials of the vitamin C sodium microcapsule, so that the vitamin C sodium capsule has good film forming property, good mechanical stability, good biocompatibility and increased strength and compactness of the microcapsule film, and raw materials are easy to obtain and low in price; the lecithin and the Tween-80 are selected to prepare the composite emulsifier, spray drying process conditions are optimized, the air inlet temperature is 185-190 ℃, and the spray drying method with the air outlet temperature of 80-85 ℃ is adopted, so that the prepared vitamin C sodium capsule has higher embedding rate and retention rate, and meanwhile, the moisture content in the vitamin C sodium microcapsule is low, thereby being beneficial to the preservation of products, ensuring the stability of the performance of the vitamin C sodium capsule and prolonging the shelf life of the products.
Compared with the vitamin C oral preparation, the vitamin C sodium capsule provided by the invention has the advantages of quicker and more sufficient absorption and higher bioavailability. In addition, vitamin C is absorbed from the intestine into the blood circulation by diffusion or sodium ion channels. Vitamin C cannot directly pass through the sodium ion channel and can pass through the sodium ion channel only in the form of a vitamin C sodium compound after being combined with sodium ions, and vitamin C sodium can directly pass through the sodium ion channel, so that the absorption speed of the vitamin C sodium is nearly hundreds of times faster than that of the vitamin C, and the bioavailability is greatly improved.
Under radiation exposure, radiation can trigger oxidative stress reaction to generate active oxygen with strong oxidation effect, and the active oxygen can damage cell membranes and genes and also damage organs such as marrow, intestinal tracts and the like. The vitamin C sodium capsule is a high-efficiency antioxidant, can block free radical reaction, can eliminate active oxygen generated by radiation by reducing the generation of oxidation free radicals, and can reduce the damage of lipid peroxide to skin, organs and the like.
The vitamin C sodium capsule can accelerate the healing of wounds of patients after surgical operations. The treatment group was orally administered 1g of vitamin C sodium capsule per day by double-blind experiment, and the control group was not treated. After one month, the wound healing rate of the treatment group reached 84% and the control group was only 43%. In addition, the wound dehiscence rate is closely related to low plasma ascorbic acid levels. Of 875 post-surgical patients, the plasma ascorbate level was 13.9% for low patient wound dehiscence, whereas the plasma ascorbate level was only 1.7% for normal patient wound dehiscence. The mechanism is as follows: the vitamin C sodium capsule improves secretion and synthesis of collagen, and promotes wound healing.
However, the foregoing description is only illustrative of the present invention and is not intended to limit the scope of the invention, so that the substitution of equivalent elements or equivalent variations and modifications within the scope of the invention are intended to fall within the scope of the claims.
Claims (8)
1. The preparation method of the vitamin C sodium capsule is characterized by comprising the following specific steps:
s1, preparing a lecithin solution, and adding lecithin into a buffer solution to prepare the lecithin solution;
s2, preparing a core material solution, putting sodium ascorbate and tween-80 into a lecithin solution, mixing, and carrying out high-speed shearing and stirring by a high-speed emulsifying and dispersing machine to obtain the core material solution;
s3, preparing a chitosan solution, and preparing the chitosan solution in a chitosan buffer solution;
s4, preparing a maltodextrin solution, and adding maltodextrin into the buffer solution to prepare the maltodextrin solution;
s5, preparing microcapsule emulsion, namely adding chitosan solution into core material solution while stirring, adding maltodextrin solution while stirring, performing high-speed shearing and stirring by using a high-speed emulsifying and dispersing machine, and performing high-pressure homogenization by using a homogenizer to obtain microcapsule emulsion;
s6, spray drying the microcapsule emulsion by using a spray dryer to obtain the vitamin C sodium microcapsule.
2. The method for preparing a sodium ascorbate capsule according to claim 1, wherein the buffer is a solution of sodium acetate-acetate at a concentration of 0.1mo/L and a pH of 3.0.
3. The method for preparing a vitamin C sodium capsule according to claim 2, wherein the mass ratio of lecithin to tween-80 is 2:1.
4. The method for preparing a sodium ascorbate capsule according to claim 3, wherein the high-speed emulsifying and dispersing machine is set to 10000-15000r/min and the working time is 3-5min when preparing the core material solution.
5. The method for preparing a sodium ascorbate capsule according to claim 4, wherein the high-speed emulsifying and dispersing machine is 10000-15000r/min and the working time is 3-5min when preparing microcapsule emulsion.
6. The method of claim 5, wherein the homogenizer is set to 35-40Mpa and the number of homogenization is 2-3.
7. The method for preparing a sodium ascorbate capsule of claim 6, wherein the spray dryer has an inlet air temperature of 185-190 ℃ and an outlet air temperature of 80-85 ℃.
8. A sodium vitamin C capsule prepared by the preparation method of the sodium vitamin C capsule according to claim 7, which is characterized by comprising the following raw materials in parts by weight: 6 parts of chitosan, 100 parts of maltodextrin, 65 parts of sodium ascorbate, 12 parts of lecithin and 6 parts of tween-80.
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