CN117322523A - Sustained-release composite feed additive and preparation method thereof - Google Patents
Sustained-release composite feed additive and preparation method thereof Download PDFInfo
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- 239000003674 animal food additive Substances 0.000 title claims abstract description 39
- 239000002131 composite material Substances 0.000 title claims abstract description 28
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- 238000013268 sustained release Methods 0.000 title description 3
- 239000012730 sustained-release form Substances 0.000 title description 3
- 239000011248 coating agent Substances 0.000 claims abstract description 73
- 238000000576 coating method Methods 0.000 claims abstract description 73
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 claims abstract description 34
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 claims abstract description 34
- 239000004366 Glucose oxidase Substances 0.000 claims abstract description 31
- 108010015776 Glucose oxidase Proteins 0.000 claims abstract description 31
- 239000000654 additive Substances 0.000 claims abstract description 31
- 230000000996 additive effect Effects 0.000 claims abstract description 31
- 235000019420 glucose oxidase Nutrition 0.000 claims abstract description 31
- 229940116332 glucose oxidase Drugs 0.000 claims abstract description 31
- KJPRLNWUNMBNBZ-QPJJXVBHSA-N (E)-cinnamaldehyde Chemical compound O=C\C=C\C1=CC=CC=C1 KJPRLNWUNMBNBZ-QPJJXVBHSA-N 0.000 claims abstract description 17
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000005770 Eugenol Substances 0.000 claims abstract description 17
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000005844 Thymol Substances 0.000 claims abstract description 17
- RECUKUPTGUEGMW-UHFFFAOYSA-N carvacrol Chemical compound CC(C)C1=CC=C(C)C(O)=C1 RECUKUPTGUEGMW-UHFFFAOYSA-N 0.000 claims abstract description 17
- HHTWOMMSBMNRKP-UHFFFAOYSA-N carvacrol Natural products CC(=C)C1=CC=C(C)C(O)=C1 HHTWOMMSBMNRKP-UHFFFAOYSA-N 0.000 claims abstract description 17
- 235000007746 carvacrol Nutrition 0.000 claims abstract description 17
- 229940117916 cinnamic aldehyde Drugs 0.000 claims abstract description 17
- KJPRLNWUNMBNBZ-UHFFFAOYSA-N cinnamic aldehyde Natural products O=CC=CC1=CC=CC=C1 KJPRLNWUNMBNBZ-UHFFFAOYSA-N 0.000 claims abstract description 17
- 229960002217 eugenol Drugs 0.000 claims abstract description 17
- 239000010643 fennel seed oil Substances 0.000 claims abstract description 17
- WYXXLXHHWYNKJF-UHFFFAOYSA-N isocarvacrol Natural products CC(C)C1=CC=C(O)C(C)=C1 WYXXLXHHWYNKJF-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000001525 mentha piperita l. herb oil Substances 0.000 claims abstract description 17
- 235000019477 peppermint oil Nutrition 0.000 claims abstract description 17
- 229960000790 thymol Drugs 0.000 claims abstract description 17
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims abstract description 15
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims abstract description 15
- 239000008108 microcrystalline cellulose Substances 0.000 claims abstract description 15
- 229940016286 microcrystalline cellulose Drugs 0.000 claims abstract description 15
- 229940068918 polyethylene glycol 400 Drugs 0.000 claims abstract description 15
- 239000000463 material Substances 0.000 claims description 34
- 238000001035 drying Methods 0.000 claims description 22
- 239000004925 Acrylic resin Substances 0.000 claims description 12
- 239000004203 carnauba wax Substances 0.000 claims description 12
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 10
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 8
- 238000003756 stirring Methods 0.000 claims description 7
- 239000005913 Maltodextrin Substances 0.000 claims description 5
- 229920002774 Maltodextrin Polymers 0.000 claims description 5
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 5
- 229940035034 maltodextrin Drugs 0.000 claims description 5
- 239000000843 powder Substances 0.000 claims description 5
- 239000000377 silicon dioxide Substances 0.000 claims description 5
- 235000012239 silicon dioxide Nutrition 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 10
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract description 10
- 239000004480 active ingredient Substances 0.000 abstract description 8
- 150000001875 compounds Chemical class 0.000 abstract description 7
- 239000000341 volatile oil Substances 0.000 abstract description 7
- 210000002784 stomach Anatomy 0.000 abstract description 6
- 230000009286 beneficial effect Effects 0.000 abstract description 4
- 238000000034 method Methods 0.000 abstract description 4
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 3
- 230000003110 anti-inflammatory effect Effects 0.000 abstract description 3
- 230000002496 gastric effect Effects 0.000 abstract description 3
- 230000008569 process Effects 0.000 abstract description 3
- 230000000052 comparative effect Effects 0.000 description 11
- 241001465754 Metazoa Species 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 241000196324 Embryophyta Species 0.000 description 4
- 238000002844 melting Methods 0.000 description 4
- 230000008018 melting Effects 0.000 description 4
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 description 3
- 238000000889 atomisation Methods 0.000 description 3
- 238000009835 boiling Methods 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 230000036039 immunity Effects 0.000 description 3
- 230000000968 intestinal effect Effects 0.000 description 3
- 230000002572 peristaltic effect Effects 0.000 description 3
- 238000001694 spray drying Methods 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 230000007413 intestinal health Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000005453 pelletization Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000003871 intestinal function Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/189—Enzymes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/105—Aliphatic or alicyclic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/111—Aromatic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/158—Fatty acids; Fats; Products containing oils or fats
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/28—Silicates, e.g. perlites, zeolites or bentonites
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/10—Shaping or working-up of animal feeding-stuffs by agglomeration; by granulation, e.g. making powders
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/30—Shaping or working-up of animal feeding-stuffs by encapsulating; by coating
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Food Science & Technology (AREA)
- Animal Husbandry (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Botany (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Physiology (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention provides a slow-release composite feed additive and a preparation method thereof, wherein the slow-release composite feed additive comprises the following components: glucose oxidase, an additive core, and a coating; wherein the additive core comprises cinnamaldehyde, eugenol, carvacrol, peppermint oil, fennel oil, thymol, microcrystalline cellulose and polyethylene glycol 400; the coating comprises an inner coating and an outer coating; the inner coating is coated on the inner additive core, and the outer coating is coated on the inner coating. The slow-release compound feed additive is coated by a coating technology, so that the heat resistance of the additive in the feed granulating process is greatly improved, the high-temperature volatile characteristic of essential oil components is effectively improved, a certain slow-release effect is achieved, the active ingredients of the additive can be released in a small amount in the stomach stage and are effectively released in the intestinal tract, and the feed additive is more convenient to store, high-temperature resistant and more beneficial to the active ingredients to exert corresponding antibacterial and anti-inflammatory effects in the gastrointestinal stage.
Description
Technical Field
The invention relates to the technical field of feed additives, in particular to a slow-release composite feed additive and a preparation method thereof.
Background
The plant essential oil is a scientific anti-microbial product widely accepted by the public, and has various biological activities such as antibiosis, deinsectization, antioxidation, anti-inflammation and the like; glucose oxidase belongs to a common antioxidant, and mainly can achieve the effect of regulating intestinal functions, so that the effect of enhancing the immunity can be achieved, the glucose oxidase is generally added into food and feed, the effects of diminishing inflammation and sterilizing can be achieved, escherichia coli can be effectively improved, and the health of intestinal tracts is facilitated.
However, the plant essential oil and the glucose oxidase are not high-temperature resistant, the plant essential oil is volatile under the high-temperature condition, the glucose oxidase is easy to deactivate under the high-temperature condition, and in order to enable more of two active ingredients to play a role in intestinal release, the invention aims to provide a slow-release compound feed additive, so that the preparation is more suitable for the high-temperature condition of feed pelletization and increases the effective release in animal intestinal tracts.
Disclosure of Invention
Based on the expression, the invention provides a slow-release composite feed additive and a preparation method thereof, so that the feed additive is more suitable for high-temperature conditions of feed pelletization and increases the effective release in animal intestinal tracts.
The technical scheme for solving the technical problems is as follows:
in a first aspect, the present invention provides a slow-release composite feed additive comprising: glucose oxidase, an additive core, and a coating;
wherein the additive core comprises cinnamaldehyde, eugenol, carvacrol, peppermint oil, fennel oil, thymol, microcrystalline cellulose and polyethylene glycol 400;
the coating comprises an inner coating and an outer coating; the inner coating is coated on the additive inner core, and the outer coating is coated on the inner coating.
On the basis of the technical scheme, the invention can be improved as follows.
Further, the mass part of the glucose oxidase is 10-15 parts;
the additive comprises the following inner cores in parts by mass: 10-15 parts by mass of glucose oxidase;
the additive comprises the following inner cores in parts by mass: 0.5 to 1 part of cinnamaldehyde, 1.5 to 3 parts of eugenol, 2 to 5 parts of carvacrol, 0.1 to 0.5 part of peppermint oil, 0.1 to 0.3 part of fennel oil, 2 to 3 parts of thymol, 1.5 to 2 parts of microcrystalline cellulose and 0.2 to 0.5 part of polyethylene glycol 400.
Further, the glucose oxidase is 10 parts by mass;
the additive comprises the following inner cores in parts by mass: 1 part of cinnamaldehyde, 3 parts of eugenol, 5 parts of carvacrol, 0.5 part of peppermint oil, 0.3 part of fennel oil, 1.5 parts of microcrystalline cellulose, 2 parts of thymol and 0.2 part of polyethylene glycol 400.
Further, the inner layer coating is polyacrylic resin II.
Further, the addition amount of the inner layer coating accounts for 10-15% of the total weight of the material.
Further, the outer coating is palm wax.
Further, the addition amount of the outer coating accounts for 15-20% of the total weight of the materials.
In a second aspect, the present invention also provides a method for preparing the slow-release composite feed additive according to the first aspect, comprising:
adding maltodextrin, silicon dioxide and calcium carbonate into the glucose oxidase liquid, and sequentially stirring and drying;
mixing the dried glucose oxidase powder with cinnamaldehyde, eugenol, carvacrol, peppermint oil, fennel oil, microcrystalline cellulose and polyethylene glycol 400, adding melted thymol after mixing, granulating after mixing uniformly, and drying to obtain an additive inner core;
and (3) performing an inner coating operation on the additive inner core by using polyacrylic resin II, and performing an outer coating operation by using palm wax.
On the basis of the technical scheme, the invention can be improved as follows.
Further, the material temperature of the inner layer coating operation is set to be 45-50 ℃; the temperature of the materials for the outer coating operation is set to be 40-42 ℃.
Compared with the prior art, the technical scheme of the application has the following beneficial technical effects:
the slow-release compound feed additive provided by the invention has the advantages that glucose oxidase, cinnamaldehyde, eugenol, carvacrol, peppermint oil, fennel oil and thymol are added into the additive as effective components, so that the food attraction of the feed can be improved, the intestinal health of animals can be improved, and the immunity of the animals can be enhanced; meanwhile, polyacrylic resin II and palm wax are selected as double-layer coating materials for coating by a coating technology, so that the heat resistance of the additive in the feed granulating process is greatly improved, the high-temperature volatile characteristic of essential oil components is effectively improved, a certain slow release effect is achieved, and the effective components of the additive can be released in a small amount in the stomach stage and are effectively released in the intestinal tract. Compared with the prior art, the compound feed additive provided by the invention is more convenient to store, resistant to high temperature and more beneficial to the active ingredients to exert corresponding antibacterial and anti-inflammatory effects in the gastrointestinal stage.
Detailed Description
In order that the present application may be readily understood, embodiments of the invention will be described in further detail with reference to the following examples, which are provided to illustrate the invention but are not intended to limit the scope thereof.
In order to increase the effective release of plant essential oil and glucose oxidase in animal intestinal tracts, the invention provides a slow-release compound feed additive, which comprises the following components: glucose oxidase, an additive core, and a coating; wherein the additive core comprises cinnamaldehyde, eugenol, carvacrol, peppermint oil, fennel oil, thymol, microcrystalline cellulose and polyethylene glycol 400;
in addition, the coating includes an inner coating and an outer coating; the inner coating is coated on the inner additive core, and the outer coating is coated on the inner coating. Wherein the inner coating is polyacrylic resin II, and the addition amount of the polyacrylic resin II accounts for 10-15% of the total weight of the materials.
The outer coating is palm wax, and the addition amount of the palm wax accounts for 15-20% of the total weight of the materials.
In an alternative embodiment, the glucose oxidase is 10 to 15 parts by mass; the additive comprises the following inner cores in parts by mass: 0.5 to 1 part of cinnamaldehyde, 1.5 to 3 parts of eugenol, 2 to 5 parts of carvacrol, 0.1 to 0.5 part of peppermint oil, 0.1 to 0.3 part of fennel oil, 2 to 3 parts of thymol, 1.5 to 2 parts of microcrystalline cellulose and 0.2 to 0.5 part of polyethylene glycol 400.
Preferably, the glucose oxidase is 10 parts by mass; the additive comprises the following inner cores in parts by mass: 1 part of cinnamaldehyde, 3 parts of eugenol, 5 parts of carvacrol, 0.5 part of peppermint oil, 0.3 part of fennel oil, 1.5 parts of microcrystalline cellulose, 2 parts of thymol and 0.2 part of polyethylene glycol 400.
Example 1
The embodiment of the invention provides a preparation method of a slow-release composite feed additive and the slow-release composite feed additive correspondingly obtained.
Step S1: and (3) drying the glucose oxidase liquid, adding 20% by weight of maltodextrin, 5% by weight of silicon dioxide and 1% by weight of calcium carbonate into the glucose oxidase liquid, uniformly stirring by using a pneumatic stirrer, and drying by using a centrifugal spray drying tower.
Wherein, the basic parameters of the drying tower are 170 ℃ of air inlet temperature, 70 ℃ of air outlet temperature and 300hz of atomization frequency.
Step S2: taking 10 parts of glucose oxidase powder, 1 part of cinnamaldehyde, 3 parts of eugenol, 5 parts of carvacrol, 0.5 part of peppermint oil, 0.3 part of fennel oil, 1.5 parts of microcrystalline cellulose and 0.2 part of polyethylene glycol 400 (PEG 400) which are dried in the step S1, putting the mixture into a wet mixing granulator, uniformly mixing, and uniformly adding 3 parts of thymol (which is required to be heated and melted) by using a peristaltic pump, and stirring for 15min to uniformly mix.
Granulating the uniformly mixed materials by using a swing granulator, drying by using a boiling drying bed, wherein the temperature of the dried materials is 42 ℃ by setting basic parameters of the drying bed, and the air inlet temperature is 42 ℃.
Step S3: putting the dried material into a centrifugal coating machine, and coating the inner layer by using polyacrylic resin II (ethanol solution) accounting for 10% of the weight of the material, wherein the temperature of the coated material is set to be 50 ℃; and (3) after the inner coating is finished, carrying out outer coating by using palm wax (hot melting) accounting for 20% of the weight of the initial material, wherein the temperature of the coated material is set to 42 ℃, and obtaining the slow-release composite feed additive after the coating is finished.
It should be noted that: the polyacrylic resin II is insoluble in water and acid, can form salt solution to dissolve in the environment with pH greater than 6, can ensure that the active ingredients are released in the intestinal environment, and the palm wax is used as an outer coating material, has the characteristic of melting point of 80-88 ℃, and accords with the temperature conditions (70-85 ℃) of most feed granulators.
Example 2
The embodiment of the invention provides a preparation method of a slow-release composite feed additive and the slow-release composite feed additive correspondingly obtained.
Step S1: and (3) drying the glucose oxidase liquid, adding 20% by weight of maltodextrin, 5% by weight of silicon dioxide and 1% by weight of calcium carbonate into the glucose oxidase liquid, uniformly stirring by using a pneumatic stirrer, and drying by using a centrifugal spray drying tower.
Wherein, the basic parameters of the drying tower are 170 ℃ of air inlet temperature, 70 ℃ of air outlet temperature and 300hz of atomization frequency.
Step S2: 15 parts of glucose oxidase powder, 0.5 part of cinnamaldehyde, 1.5 parts of eugenol, 2 parts of carvacrol, 0.1 part of peppermint oil, 0.1 part of fennel oil, 1.5 parts of microcrystalline cellulose and 0.2 part of polyethylene glycol 400 (PEG 400) which are dried in the step S1 are taken and put into a wet mixing granulator to be uniformly mixed, and 2 parts of thymol (which is required to be heated and melted) is uniformly added by a peristaltic pump to be stirred for 15min to be uniformly mixed.
Granulating the uniformly mixed materials by using a swing granulator, drying by using a boiling drying bed, wherein the temperature of the dried materials is 42 ℃ by setting basic parameters of the drying bed, and the air inlet temperature is 42 ℃.
Step S3: putting the dried material into a centrifugal coating machine, and coating the inner layer by using polyacrylic resin II (ethanol solution) accounting for 10% of the weight of the material, wherein the temperature of the coated material is set to be 50 ℃; and (3) after the inner coating is finished, carrying out outer coating by using palm wax (hot melting) accounting for 20% of the weight of the initial material, wherein the temperature of the coated material is set to 42 ℃, and obtaining the slow-release composite feed additive after the coating is finished.
Example 3
The embodiment of the invention provides a preparation method of a slow-release composite feed additive and the slow-release composite feed additive correspondingly obtained.
Step S1: and (3) drying the glucose oxidase liquid, adding 20% by weight of maltodextrin, 5% by weight of silicon dioxide and 1% by weight of calcium carbonate into the glucose oxidase liquid, uniformly stirring by using a pneumatic stirrer, and drying by using a centrifugal spray drying tower.
Wherein, the basic parameters of the drying tower are 170 ℃ of air inlet temperature, 70 ℃ of air outlet temperature and 300hz of atomization frequency.
Step S2: 13 parts of glucose oxidase powder, 0.7 part of cinnamaldehyde, 2.5 parts of eugenol, 3 parts of carvacrol, 0.3 part of peppermint oil, 0.2 part of fennel oil, 1.8 parts of microcrystalline cellulose and 0.3 part of polyethylene glycol 400 (PEG 400) which are dried in the step S1 are taken and put into a wet mixing granulator to be uniformly mixed, and 2 parts of thymol (which is required to be heated and melted) is uniformly added by a peristaltic pump to be stirred for 15min to be uniformly mixed.
Granulating the uniformly mixed materials by using a swing granulator, drying by using a boiling drying bed, wherein the temperature of the dried materials is 42 ℃ by setting basic parameters of the drying bed, and the air inlet temperature is 42 ℃.
Step S3: putting the dried material into a centrifugal coating machine, and coating the inner layer by using polyacrylic resin II (ethanol solution) accounting for 10% of the weight of the material, wherein the temperature of the coated material is set to be 50 ℃; and (3) after the inner coating is finished, carrying out outer coating by using palm wax (hot melting) accounting for 20% of the weight of the initial material, wherein the temperature of the coated material is set to 42 ℃, and obtaining the slow-release composite feed additive after the coating is finished.
Comparative example 1
The difference between this comparative example and example 1 is that: without the coating treatment, the composite feed additive is remembered after the completion of step S2.
Comparative example 2
Compared to the above-described example 2, this comparative example is different in that: without the coating treatment, the composite feed additive is remembered after the completion of step S2.
Comparative example 3
Commercially available compound feed additives of the same type, such as the same type of on-sale products of the mountain organism, are selected.
The effect of the feed additives obtained in the above examples and comparative examples was verified, 1.0000.+ -. 0.005g of each of examples 1 to 3 and comparative examples 1 to 3 was added to 400ml of hydrochloric acid solution having a pH of 3.5, and the digestion environment in the stomach and intestinal tract was simulated by using a dissolution apparatus, the temperature was controlled at 37℃and the stirring speed was controlled at 50 to 75rpm, and the pH was adjusted to 10.5 after 2 hours. Sampling at 1, 2, 3, 4, 6, and 10 hr respectively, and detecting release rate of effective components.
The test results are shown in Table 1:
table 1 results of sample testing for examples and comparative examples
In combination with table 1, it can be seen that the slow-release composite feed additive prepared by the invention has remarkable slow-release effect, most of the active ingredients in comparative example 1 and comparative example 2 which are not subjected to coating operation are released in the stomach, the intestinal release rate is only 2.51% and 3.51%, and the advocated release rate of commercial comparative example 3 is also only 2.69%; the active ingredients of examples 1 to 3 after coating operation are mostly released in the intestinal tract, and the release rates of the intestinal tract can reach 58.55%, 58.29 and 59.22%, respectively, and meanwhile, a certain amount of stomach release rate is ensured, compared with the actual sustained release effect.
In conclusion, glucose oxidase, cinnamaldehyde, eugenol, carvacrol, peppermint oil, fennel oil and thymol are added into the additive as effective components, so that the food calling property of the feed can be improved, the intestinal health of animals can be improved, and the immunity of the animals can be enhanced; meanwhile, polyacrylic resin II and palm wax are selected as double-layer coating materials for coating by a coating technology, so that the heat resistance of the additive in the feed granulating process is greatly improved, the high-temperature volatile characteristic of essential oil components is effectively improved, a certain slow release effect is achieved, and the effective components of the additive can be released in a small amount in the stomach stage and are effectively released in the intestinal tract. Compared with the prior art, the compound feed additive provided by the invention is more convenient to store, resistant to high temperature and more beneficial to the active ingredients to exert corresponding antibacterial and anti-inflammatory effects in the gastrointestinal stage.
Finally, it should be noted that: the above embodiments are only for illustrating the technical solution of the present invention, and are not limiting; although the invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit and scope of the technical solutions of the embodiments of the present invention.
Claims (9)
1. A slow release type composite feed additive, characterized by comprising: glucose oxidase, an additive core, and a coating;
wherein the additive core comprises cinnamaldehyde, eugenol, carvacrol, peppermint oil, fennel oil, thymol, microcrystalline cellulose and polyethylene glycol 400;
the coating comprises an inner coating and an outer coating; the inner coating is coated on the additive inner core, and the outer coating is coated on the inner coating.
2. The slow-release composite feed additive according to claim 1, wherein the mass part of the glucose oxidase is 10-15 parts;
the additive comprises the following inner cores in parts by mass: 0.5 to 1 part of cinnamaldehyde, 1.5 to 3 parts of eugenol, 2 to 5 parts of carvacrol, 0.1 to 0.5 part of peppermint oil, 0.1 to 0.3 part of fennel oil, 2 to 3 parts of thymol, 1.5 to 2 parts of microcrystalline cellulose and 0.2 to 0.5 part of polyethylene glycol 400.
3. The slow-release composite feed additive according to claim 1, wherein the mass part of the glucose oxidase is 10 parts;
the additive comprises the following inner cores in parts by mass: 1 part of cinnamaldehyde, 3 parts of eugenol, 5 parts of carvacrol, 0.5 part of peppermint oil, 0.3 part of fennel oil, 1.5 parts of microcrystalline cellulose, 2 parts of thymol and 0.2 part of polyethylene glycol 400.
4. The slow release composite feed additive of claim 1, wherein the inner coating is polyacrylic resin No. ii.
5. The slow release composite feed additive according to claim 4, wherein the addition amount of the inner coating accounts for 10-15% of the total weight of the material.
6. The slow release composite feed additive of claim 1, wherein the outer coating is palm wax.
7. The slow release composite feed additive according to claim 6, wherein the addition amount of the outer coating accounts for 15-20% of the total weight of the material.
8. A process for preparing the slow-release composite feed additive according to any one of claims 1 to 7, characterized by comprising:
adding maltodextrin, silicon dioxide and calcium carbonate into the glucose oxidase liquid, and sequentially stirring and drying;
mixing the dried glucose oxidase powder with cinnamaldehyde, eugenol, carvacrol, peppermint oil, fennel oil, microcrystalline cellulose and polyethylene glycol 400, adding melted thymol after mixing, granulating after mixing uniformly, and drying to obtain an additive inner core;
and (3) performing an inner coating operation on the additive inner core by using polyacrylic resin II, and performing an outer coating operation by using palm wax.
9. The preparation method according to claim 8, wherein the material temperature of the inner coating operation is set to 45-50 ℃; the temperature of the materials for the outer coating operation is set to be 40-42 ℃.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311450227.1A CN117322523A (en) | 2023-11-02 | 2023-11-02 | Sustained-release composite feed additive and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202311450227.1A CN117322523A (en) | 2023-11-02 | 2023-11-02 | Sustained-release composite feed additive and preparation method thereof |
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