CN117285645A - 一种铁蛋白纳米颗粒疫苗的制备和应用 - Google Patents
一种铁蛋白纳米颗粒疫苗的制备和应用 Download PDFInfo
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Abstract
本发明提供了一种重组蛋白，其由N个拷贝的Aβ1‑m肽和铁蛋白融合而成，其中所述N个拷贝的Aβ1‑m肽与所述铁蛋白的氨基端融合，并且N为选自1‑30的整数，m为选自6‑15的整数；优选地，所述重组蛋白包含SEQ ID NO：113至SEQ ID NO：210中任一项所示的氨基酸序列。还提供了由所述重组蛋白组成的纳米颗粒，包含编码所述重组蛋白的核苷酸序列的核酸，包括所述重组蛋白或纳米颗粒和可药用的载体的疫苗组合物。还提供了所述重组蛋白或纳米颗粒用于制备在受试者中治疗或预防阿尔茨海默病的药物的用途。
Description
技术领域
本发明涉及纳米颗粒载体技术领域，涉及分子生物学和免疫学领域。具体而言，本发明是以有序和重复的A-β1-m肽段为抗原，铁蛋白纳米颗粒为载体制备的重组蛋白颗粒。
背景技术
阿尔茨海默病(Alzheimer’s disease，简写为AD)是全球影响最广、老年人中最为常见的致死性神经退行性疾病。研究者们普遍认为大脑组织中的淀粉样-β蛋白(Amyloid-βprotein，简称Aβ)是导致神经元损伤及认知功能障碍的主要致病物质。Aβ来源于其前体物质β-淀粉样前体蛋白(β-Amyloid precursor protein，简称βAPP)。βAPP是一种跨膜蛋白，在体内各种组织中广泛存在，在脑组织中的表达量最高。βAPP在淀粉样剪切途径中，能够被切割成为长度为38至43个氨基酸不等的Aβ蛋白，其中Aβ42蛋白是形成淀粉样沉积的主要类型。
由于AD病程很长，发病机理又不明确，使之成为了新药研发领域最大的黑洞之一，在过去20年AD药物的研发失败率高达99％。目前获批的AD药物均只能在一定程度上缓解病情，并不能治愈或者阻断AD病程发展。因此，临床对预防和治疗AD的新药需求极为迫切。
目前，以刺激机体产生Aβ抗体从而清除大脑内Aβ42沉积为目的的Aβ主动免疫疫苗，是治疗AD的重要方法。Aβ42多肽疫苗作为AD疫苗的先驱，在AD转基因鼠模型中表现出了良好的延缓记忆减退的治疗效果。然而，在Aβ42多肽疫苗的临床实验中，6％的AD患者出现了脑膜炎的副反应，且患者产生的Aβ42抗体水平较低。研究表明Aβ42多肽疫苗虽然可以引起抗体反应，但是由于其携带了大量T细胞表位，会使接种患者的脑神经细胞产生自身免疫性T细胞反应从而引发脑膜炎。因此，亟需一种安全性较高且具有良好免疫效果的AD疫苗。
发明内容
本申请发明人设计了一种针对Aβ42(本文中也写作Aβ1-42)的靶向疫苗。发明人发现，对于Aβ1-m肽(即完整的Aβ42蛋白从氨基端开始前m个氨基酸组成的多肽)而言，铁蛋白纳米颗粒是非常理想的抗原展示平台。将不同拷贝数(N)、不同长度的Aβ1-m肽融合至铁蛋白的氨基端，重组蛋白的Aβ1-m肽能够展示在铁蛋白纳米颗粒的表面，形成一种有序且重复的抗原阵列，从而有利于最大程度地刺激机体产生针对Aβ42蛋白的特异性免疫反应。
第一方面，本发明提供了一种重组蛋白，其由N个拷贝的Aβ1-m肽和铁蛋白融合而成，其中所述N个拷贝的Aβ1-m肽与所述铁蛋白的氨基端融合，并且N为选自1-30的整数，m为选自6-15的整数。
第二方面，本发明提供了一种纳米颗粒，其由第一方面的重组蛋白组成。
第三方面，本发明提供了一种核酸，其包含编码第一方面的重组蛋白的核苷酸序列。
第四方面，本发明提供了一种疫苗组合物，其包含第一方面的重组蛋白或第二方面的纳米颗粒以及可药用的载体。
第五方面，本发明提供了第一方面的重组蛋白或第二方面的纳米颗粒用于制备在受试者中治疗或预防阿尔茨海默病的药物的用途。
第六方面，本发明提供了一种制备第二方面的纳米颗粒的方法，包括：
(1)合成DNA片段，其编码第一方面的重组蛋白；
(2)将所述DNA片段与载体连接，获得重组表达载体；和
(3)将所述重组表达载体转入大肠杆菌细胞或HEK 293F细胞内，从而获得稳定表达的重组蛋白并自组装形成纳米颗粒。
本发明制备的重组蛋白及疫苗组合物具有以下优势：重组铁蛋白纳米颗粒制备简单，便于纯化，其插入表位数量可控，制造成本低，制备迅速，蛋白质性质稳定，粒径均一，安全性好，免疫原性高且诱导产生的抗体滴度高；以铁蛋白纳米颗粒为载体，搭载不同拷贝数的Aβ抗原，能够极大地增强抗原的免疫原性，提高疫苗的有效性、持续性和安全性，实现对Aβ沉积的高效靶向清除，进而阻断AD进程。
附图说明
图1A为N个拷贝的Aβ1-m(其中N分别为1-30的整数，m为6、9、12)肽融合至幽门螺旋杆菌铁蛋白Ferritin氨基端并连接到pET-30a(+)载体而得到的pET30a-Ncopy-Aβ1-m-Ferritin重组质粒的示意图；图1B和图1C为将N(N＝1、3、10、20)个拷贝的Aβ1-6肽分别融合至昆虫粉纹夜蛾分泌铁蛋白iFerritin H链及L链氨基端并连接到pTT5载体而得到的pTT5-Ncopy-Aβ1-6-iFerritin重组质粒的示意图；
图2A至图2P示出了本发明的重组铁蛋白电镜表征。
图3A至图3D示出了两种重组铁蛋白3CopyAβ1-6-Ferritin和20CopyAβ1-6-Ferritin在不同免疫剂量和不同免疫佐剂存在的情况下免疫C57BL/6J小鼠后的ELISA和Elispot结果。
图4A至图4E示出了两种重组铁蛋白3CopyAβ1-6-Ferritin和20CopyAβ1-6-Ferritin通过肌肉和皮下注射两种免疫途径免疫小鼠后的ELISA及Elispot结果。
具体实施方式
在本文中，Ferritin表示幽门螺旋杆菌铁蛋白，包括其单体或24聚体；iFerritin表示昆虫粉纹夜蛾分泌铁蛋白，包括其单体或24聚体，后续也简称为昆虫铁蛋白。
除了另有说明以外，本发明中所有科技术语均使用本领域普通技术人员所通常理解的含义。
本发明提供了一种重组蛋白，其由N个拷贝的Aβ1-m肽和铁蛋白融合而成，其中所述N个拷贝的Aβ1-m肽与所述铁蛋白的氨基端融合，并且N为选自1-30的整数，m为选自6-15的整数。
优选地，所述铁蛋白为幽门螺旋杆菌铁蛋白或昆虫粉纹夜蛾分泌铁蛋白，其中昆虫粉纹夜蛾分泌铁蛋白由H链和L链组成；更优选地，幽门螺旋杆菌铁蛋白具有如SEQ IDNO：1所示的氨基酸序列，昆虫粉纹夜蛾分泌铁蛋白H链具有如SEQ ID NO：2所示的氨基酸序列，且昆虫粉纹夜蛾分泌铁蛋白L链具有如SEQ ID NO：3所示的氨基酸序列。
优选地，所述Aβ1-m肽可以是人、小鼠、灵长类、兔、光滑爪蟾、大鼠、豚鼠的Aβ1-m肽；优选地，m为6、9或12，即Aβ1-6肽、Aβ1-9肽、Aβ1-12肽是完整的Aβ42蛋白1-6位、1-9位、1-12位氨基酸组成的多肽；更优选地，人、小鼠、灵长类、兔、光滑爪蟾、大鼠、豚鼠的Aβ1-12肽具有如SEQ ID NO：4-SEQ ID NO：10所示的氨基酸序列。
优选地，所述Aβ1-m肽之4可通过氨基酸接头相连；更优选地，所述氨基酸接头为(Gly)n，优选n为1-10，更优选n＝3。
在具体实施方案中，所述重组蛋白包含SEQ ID NO：113至SEQ ID NO：210中任一项所示的氨基酸序列；优选地，所述重组蛋白包含SEQ ID NO：113、SEQ ID NO：119、SEQ IDNO：120、SEQ ID NO：121、SEQ ID NO：129、SEQ ID NO：140、SEQ ID NO：141、SEQ ID NO：142、SEQ ID NO：147、SEQ ID NO：155、SEQ ID NO：164、SEQ ID NO：170、SEQ ID NO：171、SEQ IDNO：172、SEQ ID NO：182、SEQ ID NO：200中任一项所示的氨基酸序列。
本发明还提供了一种纳米颗粒，其由本发明的重组蛋白组成。优选地，所述纳米颗粒是24聚体。
本发明还提供了一种核酸，其包含编码本发明的重组蛋白的核苷酸序列。
在具体实施方案中，所述核酸包含SEQ ID NO：15至SEQ ID NO：112中任一项所示的核苷酸序列。优选地，所述核酸包含SEQ ID NO：15、SEQ ID NO：21、SEQ ID NO：22、SEQ IDNO：23、SEQ ID NO：31、SEQ ID NO：42、SEQ ID NO：43、SEQ ID NO：44、SEQ ID NO：49、SEQ IDNO：57、SEQ ID NO：66、SEQ ID NO：72、SEQ ID NO：73、SEQ ID NO：74、SEQ ID NO：84、SEQ IDNO：102中任一项所示的核苷酸序列。
本发明提供了一种疫苗组合物，其包含本发明的重组蛋白或纳米颗粒以及可药用的载体。优选地，所述可药用的载体为佐剂；更优选地，所述佐剂包括MF59、CpG、和/或氢氧化铝；最优选地，所述佐剂为MF59和CpG。
本发明还提供了所述重组蛋白或纳米颗粒用于制备在受试者中治疗或预防阿尔茨海默病的药物的用途。
优选地，所述受试者是哺乳动物；更优选地，所述受试者是人。
优选地，所述药物为疫苗组合物；更优选地，所述疫苗组合物通过皮下途径或肌肉途径给药；最优选地，所述疫苗组合物通过肌肉途径给药。
本发明还提供了一种制备所述纳米颗粒的方法，包括：
(1)合成DNA片段，其编码本发明的重组蛋白；
(2)将所述DNA片段与载体连接，获得重组表达载体；和
(3)将所述重组表达载体转入大肠杆菌细胞或HEK 293F细胞内，从而获得稳定表达的重组蛋白并自组装形成纳米颗粒；优选地，所述纳米颗粒是24聚体形式；
优选地，所述DNA片段包含SEQ ID NO：15至SEQ ID NO：112中任一项所示的核苷酸序列；
优选地，所述方法还包括蛋白纯化步骤；更优选地，所述蛋白纯化步骤包括亲和层析和滤膜除菌。
下面以具体实施例对本发明的技术方案做进一步的说明，但本发明并不限于这些实施例。除非另有说明，本文使用的制剂和设备均为普通市售品。
实施例
实施例1表达载体构建
1.N copy-Aβ1-m-Ferritin-pET30a重组质粒的构建
选取NdeI和HindIII为融合表达的酶切位点，将N个拷贝(copy)的人Aβ1-m(其中N分别为1-30的整数，m分别为6、9、12)的核苷酸序列融合至编码幽门螺旋杆菌铁蛋白Ferritin的核苷酸序列(在Ferritin的氨基端融合)。其中每个Aβ1-m拷贝的核苷酸序列之间有编码三个甘氨酸(GGG)的核苷酸序列作为Linker，Aβ1-m核苷酸序列与Ferritin的核苷酸序列之间有编码三个甘氨酸(GGG)的核苷酸序列作为Linker。将上述合成序列连接到商用载体pET-30a(+)载体上，获得重组质粒(参见图1A)。
2.N copy-Aβ1-m-iFerritin-pTT5重组质粒的构建
将编码N个拷贝的Aβ1-m肽(其中N分别为1、3、10、20，m为6)的核苷酸序列融合至编码昆虫分泌铁蛋白H链或L链的核苷酸序列(在H链或L链的氨基端融合)。其中，每个Aβ1-m拷贝的核苷酸序列之间有编码三个甘氨酸(GGG)的核苷酸序列作为Linker，Aβ1-m核苷酸序列与昆虫分泌铁蛋白H链或L链的核苷酸序列之间有编码三个甘氨酸(GGG)的核苷酸序列作为Linker。将上述合成序列连接至pTT5载体(以上序列由南京金斯瑞生物有限公司合成并连接至pTT5载体上)，获得重组质粒(参见图1B-图1C)。
以下表1示出了编码本发明的重组铁蛋白的核苷酸序列。
表1
实施例2融合有N个拷贝的Aβ1-m免疫原的铁蛋白的表达和纯化
1.融合有N个拷贝的Aβ1-m免疫原的幽门螺旋杆菌铁蛋白的表达和纯化
分别取上述实施例1中得到的重组质粒溶液1μL(100ng)，加入到50μL大肠杆菌BL21感受态细胞(购自TransGen公司)中，冰浴30min，然后在42℃水浴中，热激90s后，冰浴2min。向混合物中加入LB培养基500μL，220rpm/min，37℃培养1h。将混合物均匀涂布在含有氨苄抗性的LB固体培养基上，37℃培养12h，即可获得稳定表达重组蛋白的菌株。取阳性菌株接种在200mL LB培养基中，37℃，220rpm培养后转入大体系中继续培养，并在培养混合物的OD值达到0.6-0.8时，用异丙基硫代半乳糖苷(IPTG，终浓度0.5mM/L)进行诱导，18℃，220rpm诱导过夜。诱导完成后，将菌液以4000rpm离心30min，弃上清，用PBS重悬菌体沉淀，再次以6000rpm离心15min，弃上清，得到含有目的蛋白的菌体的沉淀。
向获得的菌体沉淀中加入蛋白缓冲液(50mM Tris-HCl)重悬，在冰上将菌体超声破碎菌体(功率43％，超声开时间4S，超声关时间5S)，超声至菌液不再粘稠。将超声后菌液以16000rpm，4℃条件下离心30min，取上清，得到蛋白的粗提液。
利用疏水层析方法纯化蛋白，取上清液，加入一定体积的高浓度硫酸铵(4M硫酸铵，50mMTris)溶液，使样品中硫酸铵的终浓度为1.3M。用0.2μm滤器除菌过滤。首先用缓冲液A(1.3M硫酸铵，50mM Tris，PH7.0±0.2)平衡，至流出液的PH值及电导率与进液一致。上样后用缓冲液A流洗平衡系统至紫外检测仪基线平稳。平衡后用缓冲液B(50mM硫酸铵，50mMTris)梯度洗脱(10％-60％)，根据紫外检测图谱分别收集洗脱峰，检测波长280nm。最后分别用水及0.5M氢氧化钠清洗1到2个柱体积。
将不同梯度洗脱的目的蛋白通过聚丙烯酰胺凝胶电泳(SDS-PAGE)验证，将纯化目的蛋白透析至PBS溶液中并使用超滤管浓缩。使用NANO仪器测量蛋白浓度，将蛋白样品通过0.22μm滤器除菌，于-20℃冷冻保存。
2.融合有N个拷贝的Aβ1-6免疫原的昆虫分泌铁蛋白的表达和纯化
取上述实施例1中得到的重组质粒，转入大肠杆菌克隆感受态DH5α细胞，筛选阳性克隆的菌种扩大培养，并提取质粒。
用293fectinTM(Invitrogen)瞬时转染HEK 293F细胞系中表达所有的重组铁蛋白。基于重组铁蛋白的H链构建体与L链构建体进行共转染。以1copyAβ1-6-iFerritin为例，编码其H链和L链的核苷酸序列分别为SEQ ID No：105及SEQ ID No：106，用包含这两种核苷酸序列的pTT5重组质粒同时转染HEK 293F细胞。5天后收集培养上清，8000g离心45min，清除细胞碎片。
方法同上，利用疏水层析纯化蛋白，取培养上清液，加入一定体积的高浓度硫酸铵(4M硫酸铵，50mMTris)溶液，使样品中硫酸铵的终浓度为1.3M。用0.2μm滤器除菌过滤。首先用缓冲液A(1.3M硫酸铵，50mM Tris，PH7.0±0.2)平衡，至流出液的PH值及电导率与进液一致。上样后用缓冲液A流洗平衡系统至紫外检测仪基线平稳。平衡后用缓冲液B(50mM硫酸铵，50mM Tris)梯度洗脱(10％-60％)，根据紫外检测图谱分别收集洗脱峰，检测波长280nm。最后分别用水及0.5M氢氧化钠清洗1到2个柱体积。
将不同梯度洗脱的目的蛋白通过聚丙烯酰胺凝胶电泳(SDS-PAGE)验证，将纯化目的蛋白透析至PBS溶液中并使用超滤管浓缩。使用NANO仪器测量蛋白浓度，将蛋白样品通过0.22μm滤器除菌，于-20℃冷冻保存。
实施例3鉴定重组铁蛋白单体和聚体的大小
通过还原性聚丙烯酰胺凝胶电泳(SDS-PAGE)鉴定本发明的94种重组铁蛋白颗粒蛋白单体的大小。通过非变性聚丙烯酰胺凝胶电泳(Native-PAGE)鉴定重组铁蛋白颗粒蛋白形成的聚体大小。
实施例4重组铁蛋白颗粒的粒径大小和形态检测
粒径利用纳米粒径仪(购自马尔文公司)依据生产商的使用说明进行检测。分析结果表明在本发明的铁蛋白纳米颗粒中存在平均直径为10-40nm左右的颗粒。如图2A至图2P所示，电镜测试结果表明，重组铁蛋白的形态为均匀的球形，蛋白为多聚体形式。因此，上述重组铁蛋白在体外均能自组装，形成铁蛋白纳米颗粒。本发明的94种重组铁蛋白颗粒蛋白单体蛋白大小和铁蛋白纳米颗粒粒径如表2所示。
表2本发明的94种不同形式的重组铁蛋白单体蛋白大小及粒径
＊组号91-94中的重组铁蛋白分别为由各自H链和L链形成的蛋白。
实施例5重组铁蛋白免疫试验
设置以下实验组和对照组：
实验组：6-8周的雌性C57BL/6小鼠，5只/组，通过肌肉注射以上实施例制备的94种重组铁蛋白，每次注射剂量为25μg/只，佐剂为MF59(60μL/只)+CpG(10μg/只)。MF59为自制，CpG购自Takara公司，其核苷酸序列如下：TGTCGTCGTCGTTTGTCGTTTGTCGTT。
对照组：6-8周的雌性C57BL/6小鼠，5只/组，肌肉注射100μL的PBS。
免疫流程为每两周免疫一次，共免疫4次。
通过ELISA测定94种重组铁蛋白免疫后血清中Aβ42抗体的浓度，结果如表3所示。实验结果证明，所有重组铁蛋白的免疫效果均较好，能够诱导产生高浓度的抗体。
表3 94种重组铁蛋白疫苗刺激小鼠产生的Aβ42抗体的浓度
*组号91-94中的重组铁蛋白分别为由各自H链和L链形成的蛋白。
进一步地，选取3copy-Aβ1-6-Ferritin、20copy-Aβ1-6-Ferritin两种重组铁蛋白，在6-8周的雌性C57BL/6小鼠中进行免疫剂量、免疫佐剂和免疫途径的摸索。具体免疫方案如下(参见表4-6)：
(1)免疫剂量摸索：重组蛋白免疫剂量分别为每只小鼠12.5μg、25μg、50μg，免疫体积为100μL/只，每组6只小鼠。
(2)免疫佐剂摸索：使用的免疫佐剂分别为氢氧化铝佐剂(购自BrenntagBiosector公司，下表中写作“Al”)、CpG佐剂、MF59佐剂。其中Al佐剂的剂量为100μg/只，CpG佐剂剂量为10μg/只，MF59佐剂剂量为60μL/只。
(3)免疫途径摸索：免疫途径分别为肌肉免疫和皮下免疫。
表4免疫剂量摸索方案
表5免疫佐剂摸索方案
表6免疫途径摸索方案
分别在第1天、第15天、第29天、第43天进行免疫，共免疫4次，第4次免疫两周后处死小鼠。通过ELISA和Elispot实验分别检测重组铁蛋白疫苗诱导小鼠的体液免疫和细胞免疫的免疫应答。
ELISA实验具体步骤如下：每次免疫前一天对小鼠脸颊取血，血样37℃放置2h后，4℃放置1h，3500rpm，离心40min，取上层血清，冻存待用。以Aβ42(购自上海吉尔生化公司)为抗原，用无菌PBS配制成1mg/ml溶液，用抗原包被液稀释至1μg/μL，包被96孔板，每孔100μL，4℃包被过夜。每孔用200μL PBST(pH7.4，0.01mol/L PBS，含有0.05％Tween-20)洗涤三次后，加入封闭液(pH7.4，0.01mol/L PBS，20％的新生牛血清)，37℃封闭1h。用PBST洗涤三次，加入不同稀释梯度(1∶200、1∶800、1∶3200、1∶12800、1∶51200)的抗血清，每孔100μL，37℃，孵育2h。用PBST洗涤三次，加入0.3μg/mL的HRP(辣根过氧化物酶)山羊抗小鼠二抗(购自北京鼎国昌盛生物技术有限责任公司)，每孔100μL，37℃，孵育1小时。PBST洗涤三次，加入底物四甲基联苯胺(TMB)(购自天根生化科技有限公司)，每孔100μL，避光显色20min，每孔加入2M硫酸50μL，终止反应，酶标仪(购自Bio-rad公司)450nm处检测吸光度。
实验结果如图3A所示，所有免疫剂量都可刺激小鼠产生具有相对较高滴度的针对Aβ42的特异性抗体。
Elispot实验用于检测免疫后小鼠针对特定抗原产生IFN-γ的水平，用于评价此抗原产生的T细胞免疫反应水平。具体实验步骤如下：
利用细胞因子IFN-γ的单克隆抗体(来自Elispot试剂盒，购自BD公司)包被96孔板，浓度5μg/mL，每孔50μL，加盖4℃包被过夜。弃去包被抗体，用10％胎牛血清的完全培养基洗涤一次后，在每孔加入该完全培养基200μL，37℃封闭1h后弃去培养基。在第4次免疫两周后，小鼠颈椎脱臼处死，取其脾细胞，制成细胞浓度为1×107个/mL细胞悬液，将细胞悬液加入包被好的96孔板中，每孔100μL。每孔加入1μg/mL的特异性抗原Aβ42 100μL，37℃，5％CO2培养箱中培养24h以刺激、活化细胞。24h后，用无菌水洗板两次，无菌PBST(pH7.4，0.01mol/L PBS，含有0.05％Tween-20)缓冲液洗涤6次，洗去细胞。每孔加入50μL IFN-γ的抗体(来自Elispot试剂盒，购自BD公司，抗体浓度为2μg/mL)，室温孵育2h。洗涤96孔板，每孔加入50μL辣根过氧化物标记的生物素二抗(来自Elispot试剂盒，购自BD公司)，室温培养2h，PBST洗涤4次，PBS洗涤2次后，每孔加50μl Elispot显色液(AEC底物)，避光室温反应5-60min，弃去染色液，用蒸馏水洗涤，过夜干燥后，利用显微镜计算出样品中被激活细胞的数目。
Elispot实验结果如图3B所示，用Aβ42刺激经两种重组铁蛋白免疫的小鼠的脾细胞产生很少的IFN-γ阳性斑点。表明两种重组铁蛋白在每个免疫剂量下，均不会刺激机体产生T细胞反应，证明了疫苗的安全性。
根据表5中的方案对免疫佐剂进行摸索。ELISA实验结果如图3C所示，当重组蛋白免疫剂量为25μg时，MF59+CpG作为佐剂和Al+CpG作为佐剂时实验组小鼠均产生具有相对较高滴度的针对Aβ42的特异性抗体。
Elispot实验结果如图3D所示，佐剂包含氢氧化铝的实验组有较多的IFN-γ斑点数出现，证明氢氧化铝佐剂会刺激机体产生一定的T细胞反应。而25μg的3copyAβ1-6-Ferritin+佐剂MF59+CpG或20copyAβ1-6-Ferritin+佐剂MF59+CpG实验组仅有较少的阳性斑点数，证明其在体内无明显的T细胞反应发生，并且如上文所述，该免疫策略能够刺激小鼠产生相对较高滴度的针对于Aβ42的特异性抗体。
根据表6中的方案对免疫途径进行摸索，结果如图4A-4E所示。重组铁蛋白剂量为25μg/只，以MF59(60μL/只)+CpG(10μg/只)为佐剂，将两种重组铁蛋白3Copy-Aβ1-6-Ferritin和20Copy-Aβ1-6-Ferritin通过肌肉注射和皮下注射两种免疫途径对6-8周的雌性C57BL/6小鼠进行免疫。如图4A-4D所示，随免疫次数的增加，两种重组铁蛋白疫苗刺激小鼠机体产生针对于Aβ42的特异性抗体的滴度逐渐升高。在第四次免疫时，抗体水平达到最高值，说明本发明疫苗具有良好的免疫原性。两种免疫方式都能够产生针对Aβ42的特异性抗体，其OD值都明显高于PBS组和CpG组，通过对比可知，肌肉免疫的效果要好于皮下免疫。
序列描述
SEQ ID NO：1为幽门螺旋杆菌铁蛋白的氨基酸序列。
SEQ ID NO：2为昆虫粉纹夜蛾分泌铁蛋白H链氨基酸序列。
SEQ ID NO：3为昆虫粉纹夜蛾分泌铁蛋白L链氨基酸序列。
SEQ ID NO：4-10分别为人、小鼠、灵长类、兔、光滑爪蟾、大鼠、豚鼠的Aβ1-12肽的氨基酸序列。
SEQ ID NO：11为编码幽门螺旋杆菌铁蛋白的核苷酸序列。
SEQ ID NO：12为编码昆虫粉纹夜蛾分泌铁蛋白H链的核苷酸序列。
SEQ ID NO：13为编码昆虫粉纹夜蛾分泌铁蛋白L链的核苷酸序列。
SEQ ID NO：14为编码人Aβ1-12肽的核苷酸序列。
SEQ ID NO：15-SEQ ID NO：112为编码本发明实施例中制备的重组铁蛋白的核苷酸序列。
SEQ ID NO：113-SEQ ID NO：210为本发明实施例中制备的重组铁蛋白的氨基酸序列。
序列表
<110> 长春百克生物科技股份公司
<120> 一种铁蛋白纳米颗粒疫苗的制备和应用
<160> 210
<170> SIPOSequenceListing 1.0
<210> 1
<211> 163
<212> PRT
<213> 幽门螺旋杆菌(Helicobacter pylori)
<400> 1
Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Asn Ser
1 5 10 15
Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu
20 25 30
Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu
35 40 45
His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val
50 55 60
Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr
65 70 75 80
Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser
85 90 95
Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr
100 105 110
Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val
115 120 125
Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn
130 135 140
His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser
145 150 155 160
Arg Lys Ser
<210> 2
<211> 191
<212> PRT
<213> 粉纹夜蛾(Trichoplusia ni)
<400> 2
Thr Gln Cys Asn Val Asn Pro Val Gln Ile Pro Lys Asp Trp Ile Thr
1 5 10 15
Met His Arg Ser Cys Arg Asn Ser Met Arg Gln Gln Ile Gln Met Glu
20 25 30
Val Gly Ala Ser Leu Gln Tyr Leu Ala Met Gly Ala His Phe Ser Lys
35 40 45
Asp Val Val Asn Arg Pro Gly Phe Ala Gln Leu Phe Phe Asp Ala Ala
50 55 60
Ser Glu Glu Arg Glu His Ala Met Lys Leu Ile Glu Tyr Leu Leu Met
65 70 75 80
Arg Gly Glu Leu Thr Asn Asp Val Ser Ser Leu Leu Gln Val Arg Pro
85 90 95
Pro Thr Arg Ser Ser Trp Lys Gly Gly Val Glu Ala Leu Glu His Ala
100 105 110
Leu Ser Met Glu Ser Asp Val Thr Lys Ser Ile Arg Asn Val Ile Lys
115 120 125
Ala Cys Glu Asp Asp Ser Glu Phe Asn Asp Tyr His Leu Val Asp Tyr
130 135 140
Leu Thr Gly Asp Phe Leu Glu Glu Gln Tyr Lys Gly Gln Arg Asp Leu
145 150 155 160
Ala Gly Lys Ala Ser Thr Leu Lys Lys Leu Met Asp Arg His Glu Ala
165 170 175
Leu Gly Glu Phe Ile Phe Asp Lys Lys Leu Leu Gly Ile Asp Val
180 185 190
<210> 3
<211> 200
<212> PRT
<213> 粉纹夜蛾(Trichoplusia ni)
<400> 3
Gly Ile Thr Ser Asn Ser Leu Ala Leu Pro Arg Cys Asn Ala Val Tyr
1 5 10 15
Gly Glu Tyr Gly Ser His Gly Asn Val Ala Thr Glu Leu Gln Ala Tyr
20 25 30
Ala Lys Leu His Leu Glu Arg Ser Tyr Asp Tyr Leu Leu Ser Ala Ala
35 40 45
Tyr Phe Asn Asn Tyr Gln Thr Asn Arg Ala Gly Phe Ser Lys Leu Phe
50 55 60
Lys Lys Leu Ser Asp Glu Ala Trp Ser Lys Thr Ile Asp Ile Ile Lys
65 70 75 80
His Val Thr Lys Arg Gly Asp Lys Met Asn Phe Asp Gln His Ser Thr
85 90 95
Met Lys Thr Glu Arg Lys Asn Tyr Thr Ala Glu Asn His Glu Leu Glu
100 105 110
Ala Leu Ala Lys Ala Leu Asp Thr Gln Lys Glu Leu Ala Glu Arg Ala
115 120 125
Phe Tyr Ile His Arg Glu Ala Thr Arg Asn Ser Gln His Leu His Asp
130 135 140
Pro Glu Ile Ala Gln Tyr Leu Glu Glu Glu Phe Ile Glu Asp His Ala
145 150 155 160
Glu Lys Ile Arg Thr Leu Ala Gly His Thr Ser Asp Leu Lys Lys Phe
165 170 175
Ile Thr Ala Asn Asn Gly His Asp Leu Ser Leu Ala Leu Tyr Val Phe
180 185 190
Asp Glu Tyr Leu Gln Lys Thr Val
195 200
<210> 4
<211> 12
<212> PRT
<213> 智人(Homo sapiens)
<400> 4
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val
1 5 10
<210> 5
<211> 12
<212> PRT
<213> 小鼠(Mus musculus)
<400> 5
Asp Ala Glu Phe Gly His Asp Ser Gly Phe Glu Val
1 5 10
<210> 6
<211> 12
<212> PRT
<213> 灵长类(Primates)
<400> 6
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val
1 5 10
<210> 7
<211> 12
<212> PRT
<213> 家兔(Oryctolagus cuniculus)
<400> 7
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val
1 5 10
<210> 8
<211> 12
<212> PRT
<213> 爪蟾(Xenopus laevis)
<400> 8
Asp Ser Glu Tyr Arg His Asp Thr Ala Tyr Glu Val
1 5 10
<210> 9
<211> 12
<212> PRT
<213> 大鼠(Rattus norvegicus)
<400> 9
Asp Ser Glu Tyr Arg His Asp Thr Ala Tyr Glu Val
1 5 10
<210> 10
<211> 12
<212> PRT
<213> 豚鼠(Cavia porcellus)
<400> 10
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val
1 5 10
<210> 11
<211> 495
<212> DNA
<213> 幽门螺旋杆菌(Helicobacter pylori)
<400> 11
atggacatca tcaagctgct gaacgagcaa gtgaataagg agatgaacag ctccaatctg 60
tacatgtcta tgtctagctg gtgctataca cacagtctgg acggagcagg cctgttcctg 120
tttgatcacg ccgccgagga gtatgagcac gccaagaagc tgatcatctt tctgaatgag 180
aacaatgtgc ctgtgcagct gacctctatc agcgccccag agcacaagtt cgagggcctg 240
acacagatct ttcagaaggc ctacgagcac gagcagcaca tctccgagtc tatcaacaat 300
atcgtggacc acgccatcaa gtccaaggat cacgccacct tcaactttct gcagtggtac 360
gtggccgagc agcacgagga ggaggtgctg tttaaggaca tcctggataa gatcgagctg 420
atcggcaatg agaaccacgg gctgtatctg gctgaccagt atgtcaaggg catcgcaaaa 480
tcacgcaaat cataa 495
<210> 12
<211> 579
<212> DNA
<213> 粉纹夜蛾(Trichoplusia ni)
<400> 12
atgacacaat gcaatgtcaa cccggtccag attcccaagg actggatcac gatgcaccgc 60
tcctgccgca actcgatgcg tcagcagata cagatggagg tcggcgcctc gctgcagtac 120
ctggccatgg gcgctcactt ctctaaagat gtggtaaacc gacctggctt cgctcagctg 180
ttcttcgacg ccgcttcgga ggaacgtgaa cacgcgatga agcttattga atacctcctc 240
atgagaggag aactcaccaa cgatgtcagc tcactgcttc aagtcaggcc cccaactcgt 300
tcttcctgga agggtggtgt agaggccctg gaacacgcgc tgagcatgga gagtgacgtc 360
accaagagca tcaggaacgt catcaaggct tgcgaggatg acagcgaatt caatgactac 420
catcttgtcg actaccttac cggcgatttc ttggaagagc aatacaaggg acaacgcgac 480
ctcgccggca aggcctccac cctcaagaaa ctcatggacc gccatgaggc cctcggagaa 540
ttcatcttcg acaagaaact ccttggcatc gatgtctaa 579
<210> 13
<211> 606
<212> DNA
<213> 粉纹夜蛾(Trichoplusia ni)
<400> 13
atgggaataa cttctaatag ccttgctctt ccccggtgta acgcggtata cggcgagtac 60
ggtagccatg gtaacgtggc aactgagctc caagcatacg ccaagctcca cctagagagg 120
tcttacgact acctcctctc ggctgcatac ttcaacaact accagacaaa cagggccgga 180
ttcagcaaac tgttcaagaa gttatccgat gaagcctgga gcaagaccat tgatattatc 240
aagcatgtta ctaagagagg tgacaaaatg aacttcgacc agcacagcac gatgaagact 300
gaacgcaaga actacaccgc tgagaaccac gagctggagg ctctcgccaa ggctctggac 360
acacagaagg agctcgctga acgcgccttt tacatccaca gggaggccac caggaacagc 420
cagcatttac atgaccctga gatcgctcaa tacctcgaag aagagttcat tgaagaccac 480
gctgagaaga tcaggaccct cgctggtcac acctctgacc tcaagaagtt catcacggcc 540
aacaacggac acgacttgtc tctggccttg tacgtcttcg acgaatacct ccagaagacc 600
gtttaa 606
<210> 14
<211> 36
<212> DNA
<213> 智人(Homo sapiens)
<400> 14
gatgcagaat tccgacatga ctcaggatat gaagtt 36
<210> 15
<211> 522
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 15
atggatgcag aattccgaca tggaggagga gacatcatca agctgctgaa cgagcaagtg 60
aataaggaga tgaacagctc caatctgtac atgtctatgt ctagctggtg ctatacacac 120
agtctggacg gagcaggcct gttcctgttt gatcacgccg ccgaggagta tgagcacgcc 180
aagaagctga tcatctttct gaatgagaac aatgtgcctg tgcagctgac ctctatcagc 240
gccccagagc acaagttcga gggcctgaca cagatctttc agaaggccta cgagcacgag 300
cagcacatct ccgagtctat caacaatatc gtggaccacg ccatcaagtc caaggatcac 360
gccaccttca actttctgca gtggtacgtg gccgagcagc acgaggagga ggtgctgttt 420
aaggacatcc tggataagat cgagctgatc ggcaatgaga accacgggct gtatctggct 480
gaccagtatg tcaagggcat cgcaaaatca cgcaaatcat aa 522
<210> 16
<211> 531
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 16
atggatgcag aattccgaca tgactcagga ggaggaggag acatcatcaa gctgctgaac 60
gagcaagtga ataaggagat gaacagctcc aatctgtaca tgtctatgtc tagctggtgc 120
tatacacaca gtctggacgg agcaggcctg ttcctgtttg atcacgccgc cgaggagtat 180
gagcacgcca agaagctgat catctttctg aatgagaaca atgtgcctgt gcagctgacc 240
tctatcagcg ccccagagca caagttcgag ggcctgacac agatctttca gaaggcctac 300
gagcacgagc agcacatctc cgagtctatc aacaatatcg tggaccacgc catcaagtcc 360
aaggatcacg ccaccttcaa ctttctgcag tggtacgtgg ccgagcagca cgaggaggag 420
gtgctgttta aggacatcct ggataagatc gagctgatcg gcaatgagaa ccacgggctg 480
tatctggctg accagtatgt caagggcatc gcaaaatcac gcaaatcata a 531
<210> 17
<211> 540
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 17
atggatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga catcatcaag 60
ctgctgaacg agcaagtgaa taaggagatg aacagctcca atctgtacat gtctatgtct 120
agctggtgct atacacacag tctggacgga gcaggcctgt tcctgtttga tcacgccgcc 180
gaggagtatg agcacgccaa gaagctgatc atctttctga atgagaacaa tgtgcctgtg 240
cagctgacct ctatcagcgc cccagagcac aagttcgagg gcctgacaca gatctttcag 300
aaggcctacg agcacgagca gcacatctcc gagtctatca acaatatcgt ggaccacgcc 360
atcaagtcca aggatcacgc caccttcaac tttctgcagt ggtacgtggc cgagcagcac 420
gaggaggagg tgctgtttaa ggacatcctg gataagatcg agctgatcgg caatgagaac 480
cacgggctgt atctggctga ccagtatgtc aagggcatcg caaaatcacg caaatcataa 540
<210> 18
<211> 548
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 18
atggatgcag aattccgaca tggaggagga gatgcagaat tccgacatgg aggaggagac 60
atcatcaagc tgctgaacga gcaagtgaat aaggagatga acagctccaa tctgtacatg 120
tctatgtcta gctggtgcta tacacacagt ctggacggag caggcctgtt cctgtttgat 180
cacgccgccg aggagtatga gcacgccaag aagctgatca tctttctgaa tgagaacaat 240
gtgcctgtgc agctgacctc tatcagcgcc ccagagcaca agttcgaggg cctgacacag 300
atctttcaga aggcctacga gcacgagcag cacatctccg agtctatcaa caatatcgtg 360
gaccacgcca tcaagtccaa ggatcacgcc accttcaact ttctgcagtg gtacgtggcc 420
gagcagcacg aggaggaggt gctgtttaag gacatcctgg ataagatcga gctgatcggc 480
aatgagaacc acgggctgta tctggctgac cagtatgtca agggcatcgc aaaatcacgc 540
aaatcaaa 548
<210> 19
<211> 567
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 19
atggatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 60
tcaggaggag gaggagacat catcaagctg ctgaacgagc aagtgaataa ggagatgaac 120
agctccaatc tgtacatgtc tatgtctagc tggtgctata cacacagtct ggacggagca 180
ggcctgttcc tgtttgatca cgccgccgag gagtatgagc acgccaagaa gctgatcatc 240
tttctgaatg agaacaatgt gcctgtgcag ctgacctcta tcagcgcccc agagcacaag 300
ttcgagggcc tgacacagat ctttcagaag gcctacgagc acgagcagca catctccgag 360
tctatcaaca atatcgtgga ccacgccatc aagtccaagg atcacgccac cttcaacttt 420
ctgcagtggt acgtggccga gcagcacgag gaggaggtgc tgtttaagga catcctggat 480
aagatcgagc tgatcggcaa tgagaaccac gggctgtatc tggctgacca gtatgtcaag 540
ggcatcgcaa aatcacgcaa atcataa 567
<210> 20
<211> 585
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 20
atggatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 60
cgacatgact caggatatga agttggagga ggagacatca tcaagctgct gaacgagcaa 120
gtgaataagg agatgaacag ctccaatctg tacatgtcta tgtctagctg gtgctataca 180
cacagtctgg acggagcagg cctgttcctg tttgatcacg ccgccgagga gtatgagcac 240
gccaagaagc tgatcatctt tctgaatgag aacaatgtgc ctgtgcagct gacctctatc 300
agcgccccag agcacaagtt cgagggcctg acacagatct ttcagaaggc ctacgagcac 360
gagcagcaca tctccgagtc tatcaacaat atcgtggacc acgccatcaa gtccaaggat 420
cacgccacct tcaactttct gcagtggtac gtggccgagc agcacgagga ggaggtgctg 480
tttaaggaca tcctggataa gatcgagctg atcggcaatg agaaccacgg gctgtatctg 540
gctgaccagt atgtcaaggg catcgcaaaa tcacgcaaat cataa 585
<210> 21
<211> 576
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 21
atggatgcag aattccgaca tggaggagga gatgcagaat tccgacatgg aggaggagat 60
gcagaattcc gacatggagg aggagacatc atcaagctgc tgaacgagca agtgaataag 120
gagatgaaca gctccaatct gtacatgtct atgtctagct ggtgctatac acacagtctg 180
gacggagcag gcctgttcct gtttgatcac gccgccgagg agtatgagca cgccaagaag 240
ctgatcatct ttctgaatga gaacaatgtg cctgtgcagc tgacctctat cagcgcccca 300
gagcacaagt tcgagggcct gacacagatc tttcagaagg cctacgagca cgagcagcac 360
atctccgagt ctatcaacaa tatcgtggac cacgccatca agtccaagga tcacgccacc 420
ttcaactttc tgcagtggta cgtggccgag cagcacgagg aggaggtgct gtttaaggac 480
atcctggata agatcgagct gatcggcaat gagaaccacg ggctgtatct ggctgaccag 540
tatgtcaagg gcatcgcaaa atcacgcaaa tcataa 576
<210> 22
<211> 603
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 22
atggatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 60
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agacatcatc 120
aagctgctga acgagcaagt gaataaggag atgaacagct ccaatctgta catgtctatg 180
tctagctggt gctatacaca cagtctggac ggagcaggcc tgttcctgtt tgatcacgcc 240
gccgaggagt atgagcacgc caagaagctg atcatctttc tgaatgagaa caatgtgcct 300
gtgcagctga cctctatcag cgccccagag cacaagttcg agggcctgac acagatcttt 360
cagaaggcct acgagcacga gcagcacatc tccgagtcta tcaacaatat cgtggaccac 420
gccatcaagt ccaaggatca cgccaccttc aactttctgc agtggtacgt ggccgagcag 480
cacgaggagg aggtgctgtt taaggacatc ctggataaga tcgagctgat cggcaatgag 540
aaccacgggc tgtatctggc tgaccagtat gtcaagggca tcgcaaaatc acgcaaatca 600
taa 603
<210> 23
<211> 630
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 23
atggatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 60
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 120
tatgaagttg gaggaggaga catcatcaag ctgctgaacg agcaagtgaa taaggagatg 180
aacagctcca atctgtacat gtctatgtct agctggtgct atacacacag tctggacgga 240
gcaggcctgt tcctgtttga tcacgccgcc gaggagtatg agcacgccaa gaagctgatc 300
atctttctga atgagaacaa tgtgcctgtg cagctgacct ctatcagcgc cccagagcac 360
aagttcgagg gcctgacaca gatctttcag aaggcctacg agcacgagca gcacatctcc 420
gagtctatca acaatatcgt ggaccacgcc atcaagtcca aggatcacgc caccttcaac 480
tttctgcagt ggtacgtggc cgagcagcac gaggaggagg tgctgtttaa ggacatcctg 540
gataagatcg agctgatcgg caatgagaac cacgggctgt atctggctga ccagtatgtc 600
aagggcatcg caaaatcacg caaatcataa 630
<210> 24
<211> 603
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 24
atggatgcag aattccgaca tggaggagga gatgcagaat tccgacatgg aggaggagat 60
gcagaattcc gacatggagg aggagatgca gaattccgac atggaggagg agacatcatc 120
aagctgctga acgagcaagt gaataaggag atgaacagct ccaatctgta catgtctatg 180
tctagctggt gctatacaca cagtctggac ggagcaggcc tgttcctgtt tgatcacgcc 240
gccgaggagt atgagcacgc caagaagctg atcatctttc tgaatgagaa caatgtgcct 300
gtgcagctga cctctatcag cgccccagag cacaagttcg agggcctgac acagatcttt 360
cagaaggcct acgagcacga gcagcacatc tccgagtcta tcaacaatat cgtggaccac 420
gccatcaagt ccaaggatca cgccaccttc aactttctgc agtggtacgt ggccgagcag 480
cacgaggagg aggtgctgtt taaggacatc ctggataaga tcgagctgat cggcaatgag 540
aaccacgggc tgtatctggc tgaccagtat gtcaagggca tcgcaaaatc acgcaaatca 600
taa 603
<210> 25
<211> 639
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 25
atggatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 60
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 120
ttccgacatg actcaggagg aggaggagac atcatcaagc tgctgaacga gcaagtgaat 180
aaggagatga acagctccaa tctgtacatg tctatgtcta gctggtgcta tacacacagt 240
ctggacggag caggcctgtt cctgtttgat cacgccgccg aggagtatga gcacgccaag 300
aagctgatca tctttctgaa tgagaacaat gtgcctgtgc agctgacctc tatcagcgcc 360
ccagagcaca agttcgaggg cctgacacag atctttcaga aggcctacga gcacgagcag 420
cacatctccg agtctatcaa caatatcgtg gaccacgcca tcaagtccaa ggatcacgcc 480
accttcaact ttctgcagtg gtacgtggcc gagcagcacg aggaggaggt gctgtttaag 540
gacatcctgg ataagatcga gctgatcggc aatgagaacc acgggctgta tctggctgac 600
cagtatgtca agggcatcgc aaaatcacgc aaatcataa 639
<210> 26
<211> 675
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 26
atggatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 60
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 120
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 180
ggagacatca tcaagctgct gaacgagcaa gtgaataagg agatgaacag ctccaatctg 240
tacatgtcta tgtctagctg gtgctataca cacagtctgg acggagcagg cctgttcctg 300
tttgatcacg ccgccgagga gtatgagcac gccaagaagc tgatcatctt tctgaatgag 360
aacaatgtgc ctgtgcagct gacctctatc agcgccccag agcacaagtt cgagggcctg 420
acacagatct ttcagaaggc ctacgagcac gagcagcaca tctccgagtc tatcaacaat 480
atcgtggacc acgccatcaa gtccaaggat cacgccacct tcaactttct gcagtggtac 540
gtggccgagc agcacgagga ggaggtgctg tttaaggaca tcctggataa gatcgagctg 600
atcggcaatg agaaccacgg gctgtatctg gctgaccagt atgtcaaggg catcgcaaaa 660
tcacgcaaat cataa 675
<210> 27
<211> 630
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 27
atggatgcag aattccgaca tggaggagga gatgcagaat tccgacatgg aggaggagat 60
gcagaattcc gacatggagg aggagatgca gaattccgac atggaggagg agatgcagaa 120
ttccgacatg gaggaggaga catcatcaag ctgctgaacg agcaagtgaa taaggagatg 180
aacagctcca atctgtacat gtctatgtct agctggtgct atacacacag tctggacgga 240
gcaggcctgt tcctgtttga tcacgccgcc gaggagtatg agcacgccaa gaagctgatc 300
atctttctga atgagaacaa tgtgcctgtg cagctgacct ctatcagcgc cccagagcac 360
aagttcgagg gcctgacaca gatctttcag aaggcctacg agcacgagca gcacatctcc 420
gagtctatca acaatatcgt ggaccacgcc atcaagtcca aggatcacgc caccttcaac 480
tttctgcagt ggtacgtggc cgagcagcac gaggaggagg tgctgtttaa ggacatcctg 540
gataagatcg agctgatcgg caatgagaac cacgggctgt atctggctga ccagtatgtc 600
aagggcatcg caaaatcacg caaatcataa 630
<210> 28
<211> 675
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 28
atggatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 60
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 120
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 180
ggagacatca tcaagctgct gaacgagcaa gtgaataagg agatgaacag ctccaatctg 240
tacatgtcta tgtctagctg gtgctataca cacagtctgg acggagcagg cctgttcctg 300
tttgatcacg ccgccgagga gtatgagcac gccaagaagc tgatcatctt tctgaatgag 360
aacaatgtgc ctgtgcagct gacctctatc agcgccccag agcacaagtt cgagggcctg 420
acacagatct ttcagaaggc ctacgagcac gagcagcaca tctccgagtc tatcaacaat 480
atcgtggacc acgccatcaa gtccaaggat cacgccacct tcaactttct gcagtggtac 540
gtggccgagc agcacgagga ggaggtgctg tttaaggaca tcctggataa gatcgagctg 600
atcggcaatg agaaccacgg gctgtatctg gctgaccagt atgtcaaggg catcgcaaaa 660
tcacgcaaat cataa 675
<210> 29
<211> 720
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 29
atggatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 60
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 120
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 180
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga catcatcaag 240
ctgctgaacg agcaagtgaa taaggagatg aacagctcca atctgtacat gtctatgtct 300
agctggtgct atacacacag tctggacgga gcaggcctgt tcctgtttga tcacgccgcc 360
gaggagtatg agcacgccaa gaagctgatc atctttctga atgagaacaa tgtgcctgtg 420
cagctgacct ctatcagcgc cccagagcac aagttcgagg gcctgacaca gatctttcag 480
aaggcctacg agcacgagca gcacatctcc gagtctatca acaatatcgt ggaccacgcc 540
atcaagtcca aggatcacgc caccttcaac tttctgcagt ggtacgtggc cgagcagcac 600
gaggaggagg tgctgtttaa ggacatcctg gataagatcg agctgatcgg caatgagaac 660
cacgggctgt atctggctga ccagtatgtc aagggcatcg caaaatcacg caaatcataa 720
<210> 30
<211> 657
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 30
atggatgcag aattccgaca tggaggagga gatgcagaat tccgacatgg aggaggagat 60
gcagaattcc gacatggagg aggagatgca gaattccgac atggaggagg agatgcagaa 120
ttccgacatg gaggaggaga tgcagaattc cgacatggag gaggagacat catcaagctg 180
ctgaacgagc aagtgaataa ggagatgaac agctccaatc tgtacatgtc tatgtctagc 240
tggtgctata cacacagtct ggacggagca ggcctgttcc tgtttgatca cgccgccgag 300
gagtatgagc acgccaagaa gctgatcatc tttctgaatg agaacaatgt gcctgtgcag 360
ctgacctcta tcagcgcccc agagcacaag ttcgagggcc tgacacagat ctttcagaag 420
gcctacgagc acgagcagca catctccgag tctatcaaca atatcgtgga ccacgccatc 480
aagtccaagg atcacgccac cttcaacttt ctgcagtggt acgtggccga gcagcacgag 540
gaggaggtgc tgtttaagga catcctggat aagatcgagc tgatcggcaa tgagaaccac 600
gggctgtatc tggctgacca gtatgtcaag ggcatcgcaa aatcacgcaa atcataa 657
<210> 31
<211> 711
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 31
atggatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 60
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 120
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 180
ggagatgcag aattccgaca tgactcagga ggaggaggag acatcatcaa gctgctgaac 240
gagcaagtga ataaggagat gaacagctcc aatctgtaca tgtctatgtc tagctggtgc 300
tatacacaca gtctggacgg agcaggcctg ttcctgtttg atcacgccgc cgaggagtat 360
gagcacgcca agaagctgat catctttctg aatgagaaca atgtgcctgt gcagctgacc 420
tctatcagcg ccccagagca caagttcgag ggcctgacac agatctttca gaaggcctac 480
gagcacgagc agcacatctc cgagtctatc aacaatatcg tggaccacgc catcaagtcc 540
aaggatcacg ccaccttcaa ctttctgcag tggtacgtgg ccgagcagca cgaggaggag 600
gtgctgttta aggacatcct ggataagatc gagctgatcg gcaatgagaa ccacgggctg 660
tatctggctg accagtatgt caagggcatc gcaaaatcac gcaaatcata a 711
<210> 32
<211> 765
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 32
atggatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 60
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 120
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 180
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 240
cgacatgact caggatatga agttggagga ggagacatca tcaagctgct gaacgagcaa 300
gtgaataagg agatgaacag ctccaatctg tacatgtcta tgtctagctg gtgctataca 360
cacagtctgg acggagcagg cctgttcctg tttgatcacg ccgccgagga gtatgagcac 420
gccaagaagc tgatcatctt tctgaatgag aacaatgtgc ctgtgcagct gacctctatc 480
agcgccccag agcacaagtt cgagggcctg acacagatct ttcagaaggc ctacgagcac 540
gagcagcaca tctccgagtc tatcaacaat atcgtggacc acgccatcaa gtccaaggat 600
cacgccacct tcaactttct gcagtggtac gtggccgagc agcacgagga ggaggtgctg 660
tttaaggaca tcctggataa gatcgagctg atcggcaatg agaaccacgg gctgtatctg 720
gctgaccagt atgtcaaggg catcgcaaaa tcacgcaaat cataa 765
<210> 33
<211> 684
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 33
atggatgcag aattccgaca tggaggagga gatgcagaat tccgacatgg aggaggagat 60
gcagaattcc gacatggagg aggagatgca gaattccgac atggaggagg agatgcagaa 120
ttccgacatg gaggaggaga tgcagaattc cgacatggag gaggagatgc agaattccga 180
catggaggag gagacatcat caagctgctg aacgagcaag tgaataagga gatgaacagc 240
tccaatctgt acatgtctat gtctagctgg tgctatacac acagtctgga cggagcaggc 300
ctgttcctgt ttgatcacgc cgccgaggag tatgagcacg ccaagaagct gatcatcttt 360
ctgaatgaga acaatgtgcc tgtgcagctg acctctatca gcgccccaga gcacaagttc 420
gagggcctga cacagatctt tcagaaggcc tacgagcacg agcagcacat ctccgagtct 480
atcaacaata tcgtggacca cgccatcaag tccaaggatc acgccacctt caactttctg 540
cagtggtacg tggccgagca gcacgaggag gaggtgctgt ttaaggacat cctggataag 600
atcgagctga tcggcaatga gaaccacggg ctgtatctgg ctgaccagta tgtcaagggc 660
atcgcaaaat cacgcaaatc ataa 684
<210> 34
<211> 747
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 34
atggatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 60
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 120
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 180
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 240
tcaggaggag gaggagacat catcaagctg ctgaacgagc aagtgaataa ggagatgaac 300
agctccaatc tgtacatgtc tatgtctagc tggtgctata cacacagtct ggacggagca 360
ggcctgttcc tgtttgatca cgccgccgag gagtatgagc acgccaagaa gctgatcatc 420
tttctgaatg agaacaatgt gcctgtgcag ctgacctcta tcagcgcccc agagcacaag 480
ttcgagggcc tgacacagat ctttcagaag gcctacgagc acgagcagca catctccgag 540
tctatcaaca atatcgtgga ccacgccatc aagtccaagg atcacgccac cttcaacttt 600
ctgcagtggt acgtggccga gcagcacgag gaggaggtgc tgtttaagga catcctggat 660
aagatcgagc tgatcggcaa tgagaaccac gggctgtatc tggctgacca gtatgtcaag 720
ggcatcgcaa aatcacgcaa atcataa 747
<210> 35
<211> 810
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 35
atggatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 60
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 120
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 180
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 240
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 300
tatgaagttg gaggaggaga catcatcaag ctgctgaacg agcaagtgaa taaggagatg 360
aacagctcca atctgtacat gtctatgtct agctggtgct atacacacag tctggacgga 420
gcaggcctgt tcctgtttga tcacgccgcc gaggagtatg agcacgccaa gaagctgatc 480
atctttctga atgagaacaa tgtgcctgtg cagctgacct ctatcagcgc cccagagcac 540
aagttcgagg gcctgacaca gatctttcag aaggcctacg agcacgagca gcacatctcc 600
gagtctatca acaatatcgt ggaccacgcc atcaagtcca aggatcacgc caccttcaac 660
tttctgcagt ggtacgtggc cgagcagcac gaggaggagg tgctgtttaa ggacatcctg 720
gataagatcg agctgatcgg caatgagaac cacgggctgt atctggctga ccagtatgtc 780
aagggcatcg caaaatcacg caaatcataa 810
<210> 36
<211> 711
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 36
atggatgcag aattccgaca tggaggagga gatgcagaat tccgacatgg aggaggagat 60
gcagaattcc gacatggagg aggagatgca gaattccgac atggaggagg agatgcagaa 120
ttccgacatg gaggaggaga tgcagaattc cgacatggag gaggagatgc agaattccga 180
catggaggag gagatgcaga attccgacat ggaggaggag acatcatcaa gctgctgaac 240
gagcaagtga ataaggagat gaacagctcc aatctgtaca tgtctatgtc tagctggtgc 300
tatacacaca gtctggacgg agcaggcctg ttcctgtttg atcacgccgc cgaggagtat 360
gagcacgcca agaagctgat catctttctg aatgagaaca atgtgcctgt gcagctgacc 420
tctatcagcg ccccagagca caagttcgag ggcctgacac agatctttca gaaggcctac 480
gagcacgagc agcacatctc cgagtctatc aacaatatcg tggaccacgc catcaagtcc 540
aaggatcacg ccaccttcaa ctttctgcag tggtacgtgg ccgagcagca cgaggaggag 600
gtgctgttta aggacatcct ggataagatc gagctgatcg gcaatgagaa ccacgggctg 660
tatctggctg accagtatgt caagggcatc gcaaaatcac gcaaatcata a 711
<210> 37
<211> 783
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 37
atggatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 60
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 120
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 180
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 240
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agacatcatc 300
aagctgctga acgagcaagt gaataaggag atgaacagct ccaatctgta catgtctatg 360
tctagctggt gctatacaca cagtctggac ggagcaggcc tgttcctgtt tgatcacgcc 420
gccgaggagt atgagcacgc caagaagctg atcatctttc tgaatgagaa caatgtgcct 480
gtgcagctga cctctatcag cgccccagag cacaagttcg agggcctgac acagatcttt 540
cagaaggcct acgagcacga gcagcacatc tccgagtcta tcaacaatat cgtggaccac 600
gccatcaagt ccaaggatca cgccaccttc aactttctgc agtggtacgt ggccgagcag 660
cacgaggagg aggtgctgtt taaggacatc ctggataaga tcgagctgat cggcaatgag 720
aaccacgggc tgtatctggc tgaccagtat gtcaagggca tcgcaaaatc acgcaaatca 780
taa 783
<210> 38
<211> 855
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 38
atggatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 60
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 120
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 180
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 240
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 300
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 360
ggagacatca tcaagctgct gaacgagcaa gtgaataagg agatgaacag ctccaatctg 420
tacatgtcta tgtctagctg gtgctataca cacagtctgg acggagcagg cctgttcctg 480
tttgatcacg ccgccgagga gtatgagcac gccaagaagc tgatcatctt tctgaatgag 540
aacaatgtgc ctgtgcagct gacctctatc agcgccccag agcacaagtt cgagggcctg 600
acacagatct ttcagaaggc ctacgagcac gagcagcaca tctccgagtc tatcaacaat 660
atcgtggacc acgccatcaa gtccaaggat cacgccacct tcaactttct gcagtggtac 720
gtggccgagc agcacgagga ggaggtgctg tttaaggaca tcctggataa gatcgagctg 780
atcggcaatg agaaccacgg gctgtatctg gctgaccagt atgtcaaggg catcgcaaaa 840
tcacgcaaat cataa 855
<210> 39
<211> 738
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 39
atggatgcag aattccgaca tggaggagga gatgcagaat tccgacatgg aggaggagat 60
gcagaattcc gacatggagg aggagatgca gaattccgac atggaggagg agatgcagaa 120
ttccgacatg gaggaggaga tgcagaattc cgacatggag gaggagatgc agaattccga 180
catggaggag gagatgcaga attccgacat ggaggaggag atgcagaatt ccgacatgga 240
ggaggagaca tcatcaagct gctgaacgag caagtgaata aggagatgaa cagctccaat 300
ctgtacatgt ctatgtctag ctggtgctat acacacagtc tggacggagc aggcctgttc 360
ctgtttgatc acgccgccga ggagtatgag cacgccaaga agctgatcat ctttctgaat 420
gagaacaatg tgcctgtgca gctgacctct atcagcgccc cagagcacaa gttcgagggc 480
ctgacacaga tctttcagaa ggcctacgag cacgagcagc acatctccga gtctatcaac 540
aatatcgtgg accacgccat caagtccaag gatcacgcca ccttcaactt tctgcagtgg 600
tacgtggccg agcagcacga ggaggaggtg ctgtttaagg acatcctgga taagatcgag 660
ctgatcggca atgagaacca cgggctgtat ctggctgacc agtatgtcaa gggcatcgca 720
aaatcacgca aatcataa 738
<210> 40
<211> 819
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 40
atggatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 60
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 120
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 180
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 240
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 300
ttccgacatg actcaggagg aggaggagac atcatcaagc tgctgaacga gcaagtgaat 360
aaggagatga acagctccaa tctgtacatg tctatgtcta gctggtgcta tacacacagt 420
ctggacggag caggcctgtt cctgtttgat cacgccgccg aggagtatga gcacgccaag 480
aagctgatca tctttctgaa tgagaacaat gtgcctgtgc agctgacctc tatcagcgcc 540
ccagagcaca agttcgaggg cctgacacag atctttcaga aggcctacga gcacgagcag 600
cacatctccg agtctatcaa caatatcgtg gaccacgcca tcaagtccaa ggatcacgcc 660
accttcaact ttctgcagtg gtacgtggcc gagcagcacg aggaggaggt gctgtttaag 720
gacatcctgg ataagatcga gctgatcggc aatgagaacc acgggctgta tctggctgac 780
cagtatgtca agggcatcgc aaaatcacgc aaatcataa 819
<210> 41
<211> 900
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 41
atggatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 60
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 120
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 180
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 240
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 300
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 360
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga catcatcaag 420
ctgctgaacg agcaagtgaa taaggagatg aacagctcca atctgtacat gtctatgtct 480
agctggtgct atacacacag tctggacgga gcaggcctgt tcctgtttga tcacgccgcc 540
gaggagtatg agcacgccaa gaagctgatc atctttctga atgagaacaa tgtgcctgtg 600
cagctgacct ctatcagcgc cccagagcac aagttcgagg gcctgacaca gatctttcag 660
aaggcctacg agcacgagca gcacatctcc gagtctatca acaatatcgt ggaccacgcc 720
atcaagtcca aggatcacgc caccttcaac tttctgcagt ggtacgtggc cgagcagcac 780
gaggaggagg tgctgtttaa ggacatcctg gataagatcg agctgatcgg caatgagaac 840
cacgggctgt atctggctga ccagtatgtc aagggcatcg caaaatcacg caaatcataa 900
<210> 42
<211> 765
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 42
atggatgcag aattccgaca tggaggagga gatgcagaat tccgacatgg aggaggagat 60
gcagaattcc gacatggagg aggagatgca gaattccgac atggaggagg agatgcagaa 120
ttccgacatg gaggaggaga tgcagaattc cgacatggag gaggagatgc agaattccga 180
catggaggag gagatgcaga attccgacat ggaggaggag atgcagaatt ccgacatgga 240
ggaggagatg cagaattccg acatggagga ggagacatca tcaagctgct gaacgagcaa 300
gtgaataagg agatgaacag ctccaatctg tacatgtcta tgtctagctg gtgctataca 360
cacagtctgg acggagcagg cctgttcctg tttgatcacg ccgccgagga gtatgagcac 420
gccaagaagc tgatcatctt tctgaatgag aacaatgtgc ctgtgcagct gacctctatc 480
agcgccccag agcacaagtt cgagggcctg acacagatct ttcagaaggc ctacgagcac 540
gagcagcaca tctccgagtc tatcaacaat atcgtggacc acgccatcaa gtccaaggat 600
cacgccacct tcaactttct gcagtggtac gtggccgagc agcacgagga ggaggtgctg 660
tttaaggaca tcctggataa gatcgagctg atcggcaatg agaaccacgg gctgtatctg 720
gctgaccagt atgtcaaggg catcgcaaaa tcacgcaaat cataa 765
<210> 43
<211> 855
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 43
atggatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 60
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 120
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 180
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 240
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 300
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 360
ggagacatca tcaagctgct gaacgagcaa gtgaataagg agatgaacag ctccaatctg 420
tacatgtcta tgtctagctg gtgctataca cacagtctgg acggagcagg cctgttcctg 480
tttgatcacg ccgccgagga gtatgagcac gccaagaagc tgatcatctt tctgaatgag 540
aacaatgtgc ctgtgcagct gacctctatc agcgccccag agcacaagtt cgagggcctg 600
acacagatct ttcagaaggc ctacgagcac gagcagcaca tctccgagtc tatcaacaat 660
atcgtggacc acgccatcaa gtccaaggat cacgccacct tcaactttct gcagtggtac 720
gtggccgagc agcacgagga ggaggtgctg tttaaggaca tcctggataa gatcgagctg 780
atcggcaatg agaaccacgg gctgtatctg gctgaccagt atgtcaaggg catcgcaaaa 840
tcacgcaaat cataa 855
<210> 44
<211> 945
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 44
atggatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 60
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 120
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 180
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 240
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 300
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 360
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 420
cgacatgact caggatatga agttggagga ggagacatca tcaagctgct gaacgagcaa 480
gtgaataagg agatgaacag ctccaatctg tacatgtcta tgtctagctg gtgctataca 540
cacagtctgg acggagcagg cctgttcctg tttgatcacg ccgccgagga gtatgagcac 600
gccaagaagc tgatcatctt tctgaatgag aacaatgtgc ctgtgcagct gacctctatc 660
agcgccccag agcacaagtt cgagggcctg acacagatct ttcagaaggc ctacgagcac 720
gagcagcaca tctccgagtc tatcaacaat atcgtggacc acgccatcaa gtccaaggat 780
cacgccacct tcaactttct gcagtggtac gtggccgagc agcacgagga ggaggtgctg 840
tttaaggaca tcctggataa gatcgagctg atcggcaatg agaaccacgg gctgtatctg 900
gctgaccagt atgtcaaggg catcgcaaaa tcacgcaaat cataa 945
<210> 45
<211> 792
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 45
atggatgcag aattccgaca tggaggagga gatgcagaat tccgacatgg aggaggagat 60
gcagaattcc gacatggagg aggagatgca gaattccgac atggaggagg agatgcagaa 120
ttccgacatg gaggaggaga tgcagaattc cgacatggag gaggagatgc agaattccga 180
catggaggag gagatgcaga attccgacat ggaggaggag atgcagaatt ccgacatgga 240
ggaggagatg cagaattccg acatggagga ggagatgcag aattccgaca tggaggagga 300
gacatcatca agctgctgaa cgagcaagtg aataaggaga tgaacagctc caatctgtac 360
atgtctatgt ctagctggtg ctatacacac agtctggacg gagcaggcct gttcctgttt 420
gatcacgccg ccgaggagta tgagcacgcc aagaagctga tcatctttct gaatgagaac 480
aatgtgcctg tgcagctgac ctctatcagc gccccagagc acaagttcga gggcctgaca 540
cagatctttc agaaggccta cgagcacgag cagcacatct ccgagtctat caacaatatc 600
gtggaccacg ccatcaagtc caaggatcac gccaccttca actttctgca gtggtacgtg 660
gccgagcagc acgaggagga ggtgctgttt aaggacatcc tggataagat cgagctgatc 720
ggcaatgaga accacgggct gtatctggct gaccagtatg tcaagggcat cgcaaaatca 780
cgcaaatcat aa 792
<210> 46
<211> 891
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 46
atggatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 60
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 120
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 180
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 240
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 300
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 360
ggagatgcag aattccgaca tgactcagga ggaggaggag acatcatcaa gctgctgaac 420
gagcaagtga ataaggagat gaacagctcc aatctgtaca tgtctatgtc tagctggtgc 480
tatacacaca gtctggacgg agcaggcctg ttcctgtttg atcacgccgc cgaggagtat 540
gagcacgcca agaagctgat catctttctg aatgagaaca atgtgcctgt gcagctgacc 600
tctatcagcg ccccagagca caagttcgag ggcctgacac agatctttca gaaggcctac 660
gagcacgagc agcacatctc cgagtctatc aacaatatcg tggaccacgc catcaagtcc 720
aaggatcacg ccaccttcaa ctttctgcag tggtacgtgg ccgagcagca cgaggaggag 780
gtgctgttta aggacatcct ggataagatc gagctgatcg gcaatgagaa ccacgggctg 840
tatctggctg accagtatgt caagggcatc gcaaaatcac gcaaatcata a 891
<210> 47
<211> 990
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 47
atggatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 60
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 120
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 180
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 240
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 300
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 360
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 420
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 480
tatgaagttg gaggaggaga catcatcaag ctgctgaacg agcaagtgaa taaggagatg 540
aacagctcca atctgtacat gtctatgtct agctggtgct atacacacag tctggacgga 600
gcaggcctgt tcctgtttga tcacgccgcc gaggagtatg agcacgccaa gaagctgatc 660
atctttctga atgagaacaa tgtgcctgtg cagctgacct ctatcagcgc cccagagcac 720
aagttcgagg gcctgacaca gatctttcag aaggcctacg agcacgagca gcacatctcc 780
gagtctatca acaatatcgt ggaccacgcc atcaagtcca aggatcacgc caccttcaac 840
tttctgcagt ggtacgtggc cgagcagcac gaggaggagg tgctgtttaa ggacatcctg 900
gataagatcg agctgatcgg caatgagaac cacgggctgt atctggctga ccagtatgtc 960
aagggcatcg caaaatcacg caaatcataa 990
<210> 48
<211> 819
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 48
atggatgcag aattccgaca tggaggagga gatgcagaat tccgacatgg aggaggagat 60
gcagaattcc gacatggagg aggagatgca gaattccgac atggaggagg agatgcagaa 120
ttccgacatg gaggaggaga tgcagaattc cgacatggag gaggagatgc agaattccga 180
catggaggag gagatgcaga attccgacat ggaggaggag atgcagaatt ccgacatgga 240
ggaggagatg cagaattccg acatggagga ggagatgcag aattccgaca tggaggagga 300
gatgcagaat tccgacatgg aggaggagac atcatcaagc tgctgaacga gcaagtgaat 360
aaggagatga acagctccaa tctgtacatg tctatgtcta gctggtgcta tacacacagt 420
ctggacggag caggcctgtt cctgtttgat cacgccgccg aggagtatga gcacgccaag 480
aagctgatca tctttctgaa tgagaacaat gtgcctgtgc agctgacctc tatcagcgcc 540
ccagagcaca agttcgaggg cctgacacag atctttcaga aggcctacga gcacgagcag 600
cacatctccg agtctatcaa caatatcgtg gaccacgcca tcaagtccaa ggatcacgcc 660
accttcaact ttctgcagtg gtacgtggcc gagcagcacg aggaggaggt gctgtttaag 720
gacatcctgg ataagatcga gctgatcggc aatgagaacc acgggctgta tctggctgac 780
cagtatgtca agggcatcgc aaaatcacgc aaatcataa 819
<210> 49
<211> 927
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 49
atggatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 60
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 120
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 180
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 240
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 300
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 360
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 420
tcaggaggag gaggagacat catcaagctg ctgaacgagc aagtgaataa ggagatgaac 480
agctccaatc tgtacatgtc tatgtctagc tggtgctata cacacagtct ggacggagca 540
ggcctgttcc tgtttgatca cgccgccgag gagtatgagc acgccaagaa gctgatcatc 600
tttctgaatg agaacaatgt gcctgtgcag ctgacctcta tcagcgcccc agagcacaag 660
ttcgagggcc tgacacagat ctttcagaag gcctacgagc acgagcagca catctccgag 720
tctatcaaca atatcgtgga ccacgccatc aagtccaagg atcacgccac cttcaacttt 780
ctgcagtggt acgtggccga gcagcacgag gaggaggtgc tgtttaagga catcctggat 840
aagatcgagc tgatcggcaa tgagaaccac gggctgtatc tggctgacca gtatgtcaag 900
ggcatcgcaa aatcacgcaa atcataa 927
<210> 50
<211> 1035
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 50
atggatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 60
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 120
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 180
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 240
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 300
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 360
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 420
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 480
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 540
ggagacatca tcaagctgct gaacgagcaa gtgaataagg agatgaacag ctccaatctg 600
tacatgtcta tgtctagctg gtgctataca cacagtctgg acggagcagg cctgttcctg 660
tttgatcacg ccgccgagga gtatgagcac gccaagaagc tgatcatctt tctgaatgag 720
aacaatgtgc ctgtgcagct gacctctatc agcgccccag agcacaagtt cgagggcctg 780
acacagatct ttcagaaggc ctacgagcac gagcagcaca tctccgagtc tatcaacaat 840
atcgtggacc acgccatcaa gtccaaggat cacgccacct tcaactttct gcagtggtac 900
gtggccgagc agcacgagga ggaggtgctg tttaaggaca tcctggataa gatcgagctg 960
atcggcaatg agaaccacgg gctgtatctg gctgaccagt atgtcaaggg catcgcaaaa 1020
tcacgcaaat cataa 1035
<210> 51
<211> 846
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 51
atggatgcag aattccgaca tggaggagga gatgcagaat tccgacatgg aggaggagat 60
gcagaattcc gacatggagg aggagatgca gaattccgac atggaggagg agatgcagaa 120
ttccgacatg gaggaggaga tgcagaattc cgacatggag gaggagatgc agaattccga 180
catggaggag gagatgcaga attccgacat ggaggaggag atgcagaatt ccgacatgga 240
ggaggagatg cagaattccg acatggagga ggagatgcag aattccgaca tggaggagga 300
gatgcagaat tccgacatgg aggaggagat gcagaattcc gacatggagg aggagacatc 360
atcaagctgc tgaacgagca agtgaataag gagatgaaca gctccaatct gtacatgtct 420
atgtctagct ggtgctatac acacagtctg gacggagcag gcctgttcct gtttgatcac 480
gccgccgagg agtatgagca cgccaagaag ctgatcatct ttctgaatga gaacaatgtg 540
cctgtgcagc tgacctctat cagcgcccca gagcacaagt tcgagggcct gacacagatc 600
tttcagaagg cctacgagca cgagcagcac atctccgagt ctatcaacaa tatcgtggac 660
cacgccatca agtccaagga tcacgccacc ttcaactttc tgcagtggta cgtggccgag 720
cagcacgagg aggaggtgct gtttaaggac atcctggata agatcgagct gatcggcaat 780
gagaaccacg ggctgtatct ggctgaccag tatgtcaagg gcatcgcaaa atcacgcaaa 840
tcataa 846
<210> 52
<211> 963
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 52
atggatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 60
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 120
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 180
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 240
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 300
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 360
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 420
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agacatcatc 480
aagctgctga acgagcaagt gaataaggag atgaacagct ccaatctgta catgtctatg 540
tctagctggt gctatacaca cagtctggac ggagcaggcc tgttcctgtt tgatcacgcc 600
gccgaggagt atgagcacgc caagaagctg atcatctttc tgaatgagaa caatgtgcct 660
gtgcagctga cctctatcag cgccccagag cacaagttcg agggcctgac acagatcttt 720
cagaaggcct acgagcacga gcagcacatc tccgagtcta tcaacaatat cgtggaccac 780
gccatcaagt ccaaggatca cgccaccttc aactttctgc agtggtacgt ggccgagcag 840
cacgaggagg aggtgctgtt taaggacatc ctggataaga tcgagctgat cggcaatgag 900
aaccacgggc tgtatctggc tgaccagtat gtcaagggca tcgcaaaatc acgcaaatca 960
taa 963
<210> 53
<211> 1080
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 53
atggatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 60
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 120
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 180
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 240
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 300
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 360
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 420
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 480
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 540
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga catcatcaag 600
ctgctgaacg agcaagtgaa taaggagatg aacagctcca atctgtacat gtctatgtct 660
agctggtgct atacacacag tctggacgga gcaggcctgt tcctgtttga tcacgccgcc 720
gaggagtatg agcacgccaa gaagctgatc atctttctga atgagaacaa tgtgcctgtg 780
cagctgacct ctatcagcgc cccagagcac aagttcgagg gcctgacaca gatctttcag 840
aaggcctacg agcacgagca gcacatctcc gagtctatca acaatatcgt ggaccacgcc 900
atcaagtcca aggatcacgc caccttcaac tttctgcagt ggtacgtggc cgagcagcac 960
gaggaggagg tgctgtttaa ggacatcctg gataagatcg agctgatcgg caatgagaac 1020
cacgggctgt atctggctga ccagtatgtc aagggcatcg caaaatcacg caaatcataa 1080
<210> 54
<211> 873
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 54
atggatgcag aattccgaca tggaggagga gatgcagaat tccgacatgg aggaggagat 60
gcagaattcc gacatggagg aggagatgca gaattccgac atggaggagg agatgcagaa 120
ttccgacatg gaggaggaga tgcagaattc cgacatggag gaggagatgc agaattccga 180
catggaggag gagatgcaga attccgacat ggaggaggag atgcagaatt ccgacatgga 240
ggaggagatg cagaattccg acatggagga ggagatgcag aattccgaca tggaggagga 300
gatgcagaat tccgacatgg aggaggagat gcagaattcc gacatggagg aggagatgca 360
gaattccgac atggaggagg agacatcatc aagctgctga acgagcaagt gaataaggag 420
atgaacagct ccaatctgta catgtctatg tctagctggt gctatacaca cagtctggac 480
ggagcaggcc tgttcctgtt tgatcacgcc gccgaggagt atgagcacgc caagaagctg 540
atcatctttc tgaatgagaa caatgtgcct gtgcagctga cctctatcag cgccccagag 600
cacaagttcg agggcctgac acagatcttt cagaaggcct acgagcacga gcagcacatc 660
tccgagtcta tcaacaatat cgtggaccac gccatcaagt ccaaggatca cgccaccttc 720
aactttctgc agtggtacgt ggccgagcag cacgaggagg aggtgctgtt taaggacatc 780
ctggataaga tcgagctgat cggcaatgag aaccacgggc tgtatctggc tgaccagtat 840
gtcaagggca tcgcaaaatc acgcaaatca taa 873
<210> 55
<211> 999
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 55
atggatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 60
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 120
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 180
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 240
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 300
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 360
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 420
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 480
ttccgacatg actcaggagg aggaggagac atcatcaagc tgctgaacga gcaagtgaat 540
aaggagatga acagctccaa tctgtacatg tctatgtcta gctggtgcta tacacacagt 600
ctggacggag caggcctgtt cctgtttgat cacgccgccg aggagtatga gcacgccaag 660
aagctgatca tctttctgaa tgagaacaat gtgcctgtgc agctgacctc tatcagcgcc 720
ccagagcaca agttcgaggg cctgacacag atctttcaga aggcctacga gcacgagcag 780
cacatctccg agtctatcaa caatatcgtg gaccacgcca tcaagtccaa ggatcacgcc 840
accttcaact ttctgcagtg gtacgtggcc gagcagcacg aggaggaggt gctgtttaag 900
gacatcctgg ataagatcga gctgatcggc aatgagaacc acgggctgta tctggctgac 960
cagtatgtca agggcatcgc aaaatcacgc aaatcataa 999
<210> 56
<211> 1125
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 56
atggatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 60
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 120
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 180
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 240
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 300
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 360
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 420
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 480
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 540
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 600
cgacatgact caggatatga agttggagga ggagacatca tcaagctgct gaacgagcaa 660
gtgaataagg agatgaacag ctccaatctg tacatgtcta tgtctagctg gtgctataca 720
cacagtctgg acggagcagg cctgttcctg tttgatcacg ccgccgagga gtatgagcac 780
gccaagaagc tgatcatctt tctgaatgag aacaatgtgc ctgtgcagct gacctctatc 840
agcgccccag agcacaagtt cgagggcctg acacagatct ttcagaaggc ctacgagcac 900
gagcagcaca tctccgagtc tatcaacaat atcgtggacc acgccatcaa gtccaaggat 960
cacgccacct tcaactttct gcagtggtac gtggccgagc agcacgagga ggaggtgctg 1020
tttaaggaca tcctggataa gatcgagctg atcggcaatg agaaccacgg gctgtatctg 1080
gctgaccagt atgtcaaggg catcgcaaaa tcacgcaaat cataa 1125
<210> 57
<211> 900
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 57
atggatgcag aattccgaca tggaggagga gatgcagaat tccgacatgg aggaggagat 60
gcagaattcc gacatggagg aggagatgca gaattccgac atggaggagg agatgcagaa 120
ttccgacatg gaggaggaga tgcagaattc cgacatggag gaggagatgc agaattccga 180
catggaggag gagatgcaga attccgacat ggaggaggag atgcagaatt ccgacatgga 240
ggaggagatg cagaattccg acatggagga ggagatgcag aattccgaca tggaggagga 300
gatgcagaat tccgacatgg aggaggagat gcagaattcc gacatggagg aggagatgca 360
gaattccgac atggaggagg agatgcagaa ttccgacatg gaggaggaga catcatcaag 420
ctgctgaacg agcaagtgaa taaggagatg aacagctcca atctgtacat gtctatgtct 480
agctggtgct atacacacag tctggacgga gcaggcctgt tcctgtttga tcacgccgcc 540
gaggagtatg agcacgccaa gaagctgatc atctttctga atgagaacaa tgtgcctgtg 600
cagctgacct ctatcagcgc cccagagcac aagttcgagg gcctgacaca gatctttcag 660
aaggcctacg agcacgagca gcacatctcc gagtctatca acaatatcgt ggaccacgcc 720
atcaagtcca aggatcacgc caccttcaac tttctgcagt ggtacgtggc cgagcagcac 780
gaggaggagg tgctgtttaa ggacatcctg gataagatcg agctgatcgg caatgagaac 840
cacgggctgt atctggctga ccagtatgtc aagggcatcg caaaatcacg caaatcataa 900
<210> 58
<211> 1035
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 58
atggatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 60
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 120
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 180
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 240
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 300
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 360
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 420
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 480
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 540
ggagacatca tcaagctgct gaacgagcaa gtgaataagg agatgaacag ctccaatctg 600
tacatgtcta tgtctagctg gtgctataca cacagtctgg acggagcagg cctgttcctg 660
tttgatcacg ccgccgagga gtatgagcac gccaagaagc tgatcatctt tctgaatgag 720
aacaatgtgc ctgtgcagct gacctctatc agcgccccag agcacaagtt cgagggcctg 780
acacagatct ttcagaaggc ctacgagcac gagcagcaca tctccgagtc tatcaacaat 840
atcgtggacc acgccatcaa gtccaaggat cacgccacct tcaactttct gcagtggtac 900
gtggccgagc agcacgagga ggaggtgctg tttaaggaca tcctggataa gatcgagctg 960
atcggcaatg agaaccacgg gctgtatctg gctgaccagt atgtcaaggg catcgcaaaa 1020
tcacgcaaat cataa 1035
<210> 59
<211> 1170
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 59
atggatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 60
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 120
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 180
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 240
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 300
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 360
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 420
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 480
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 540
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 600
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 660
tatgaagttg gaggaggaga catcatcaag ctgctgaacg agcaagtgaa taaggagatg 720
aacagctcca atctgtacat gtctatgtct agctggtgct atacacacag tctggacgga 780
gcaggcctgt tcctgtttga tcacgccgcc gaggagtatg agcacgccaa gaagctgatc 840
atctttctga atgagaacaa tgtgcctgtg cagctgacct ctatcagcgc cccagagcac 900
aagttcgagg gcctgacaca gatctttcag aaggcctacg agcacgagca gcacatctcc 960
gagtctatca acaatatcgt ggaccacgcc atcaagtcca aggatcacgc caccttcaac 1020
tttctgcagt ggtacgtggc cgagcagcac gaggaggagg tgctgtttaa ggacatcctg 1080
gataagatcg agctgatcgg caatgagaac cacgggctgt atctggctga ccagtatgtc 1140
aagggcatcg caaaatcacg caaatcataa 1170
<210> 60
<211> 927
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 60
atggatgcag aattccgaca tggaggagga gatgcagaat tccgacatgg aggaggagat 60
gcagaattcc gacatggagg aggagatgca gaattccgac atggaggagg agatgcagaa 120
ttccgacatg gaggaggaga tgcagaattc cgacatggag gaggagatgc agaattccga 180
catggaggag gagatgcaga attccgacat ggaggaggag atgcagaatt ccgacatgga 240
ggaggagatg cagaattccg acatggagga ggagatgcag aattccgaca tggaggagga 300
gatgcagaat tccgacatgg aggaggagat gcagaattcc gacatggagg aggagatgca 360
gaattccgac atggaggagg agatgcagaa ttccgacatg gaggaggaga tgcagaattc 420
cgacatggag gaggagacat catcaagctg ctgaacgagc aagtgaataa ggagatgaac 480
agctccaatc tgtacatgtc tatgtctagc tggtgctata cacacagtct ggacggagca 540
ggcctgttcc tgtttgatca cgccgccgag gagtatgagc acgccaagaa gctgatcatc 600
tttctgaatg agaacaatgt gcctgtgcag ctgacctcta tcagcgcccc agagcacaag 660
ttcgagggcc tgacacagat ctttcagaag gcctacgagc acgagcagca catctccgag 720
tctatcaaca atatcgtgga ccacgccatc aagtccaagg atcacgccac cttcaacttt 780
ctgcagtggt acgtggccga gcagcacgag gaggaggtgc tgtttaagga catcctggat 840
aagatcgagc tgatcggcaa tgagaaccac gggctgtatc tggctgacca gtatgtcaag 900
ggcatcgcaa aatcacgcaa atcataa 927
<210> 61
<211> 1071
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 61
atggatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 60
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 120
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 180
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 240
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 300
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 360
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 420
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 480
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 540
ggagatgcag aattccgaca tgactcagga ggaggaggag acatcatcaa gctgctgaac 600
gagcaagtga ataaggagat gaacagctcc aatctgtaca tgtctatgtc tagctggtgc 660
tatacacaca gtctggacgg agcaggcctg ttcctgtttg atcacgccgc cgaggagtat 720
gagcacgcca agaagctgat catctttctg aatgagaaca atgtgcctgt gcagctgacc 780
tctatcagcg ccccagagca caagttcgag ggcctgacac agatctttca gaaggcctac 840
gagcacgagc agcacatctc cgagtctatc aacaatatcg tggaccacgc catcaagtcc 900
aaggatcacg ccaccttcaa ctttctgcag tggtacgtgg ccgagcagca cgaggaggag 960
gtgctgttta aggacatcct ggataagatc gagctgatcg gcaatgagaa ccacgggctg 1020
tatctggctg accagtatgt caagggcatc gcaaaatcac gcaaatcata a 1071
<210> 62
<211> 1215
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 62
atggatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 60
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 120
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 180
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 240
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 300
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 360
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 420
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 480
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 540
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 600
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 660
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 720
ggagacatca tcaagctgct gaacgagcaa gtgaataagg agatgaacag ctccaatctg 780
tacatgtcta tgtctagctg gtgctataca cacagtctgg acggagcagg cctgttcctg 840
tttgatcacg ccgccgagga gtatgagcac gccaagaagc tgatcatctt tctgaatgag 900
aacaatgtgc ctgtgcagct gacctctatc agcgccccag agcacaagtt cgagggcctg 960
acacagatct ttcagaaggc ctacgagcac gagcagcaca tctccgagtc tatcaacaat 1020
atcgtggacc acgccatcaa gtccaaggat cacgccacct tcaactttct gcagtggtac 1080
gtggccgagc agcacgagga ggaggtgctg tttaaggaca tcctggataa gatcgagctg 1140
atcggcaatg agaaccacgg gctgtatctg gctgaccagt atgtcaaggg catcgcaaaa 1200
tcacgcaaat cataa 1215
<210> 63
<211> 954
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 63
atggatgcag aattccgaca tggaggagga gatgcagaat tccgacatgg aggaggagat 60
gcagaattcc gacatggagg aggagatgca gaattccgac atggaggagg agatgcagaa 120
ttccgacatg gaggaggaga tgcagaattc cgacatggag gaggagatgc agaattccga 180
catggaggag gagatgcaga attccgacat ggaggaggag atgcagaatt ccgacatgga 240
ggaggagatg cagaattccg acatggagga ggagatgcag aattccgaca tggaggagga 300
gatgcagaat tccgacatgg aggaggagat gcagaattcc gacatggagg aggagatgca 360
gaattccgac atggaggagg agatgcagaa ttccgacatg gaggaggaga tgcagaattc 420
cgacatggag gaggagatgc agaattccga catggaggag gagacatcat caagctgctg 480
aacgagcaag tgaataagga gatgaacagc tccaatctgt acatgtctat gtctagctgg 540
tgctatacac acagtctgga cggagcaggc ctgttcctgt ttgatcacgc cgccgaggag 600
tatgagcacg ccaagaagct gatcatcttt ctgaatgaga acaatgtgcc tgtgcagctg 660
acctctatca gcgccccaga gcacaagttc gagggcctga cacagatctt tcagaaggcc 720
tacgagcacg agcagcacat ctccgagtct atcaacaata tcgtggacca cgccatcaag 780
tccaaggatc acgccacctt caactttctg cagtggtacg tggccgagca gcacgaggag 840
gaggtgctgt ttaaggacat cctggataag atcgagctga tcggcaatga gaaccacggg 900
ctgtatctgg ctgaccagta tgtcaagggc atcgcaaaat cacgcaaatc ataa 954
<210> 64
<211> 1107
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 64
atggatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 60
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 120
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 180
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 240
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 300
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 360
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 420
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 480
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 540
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 600
tcaggaggag gaggagacat catcaagctg ctgaacgagc aagtgaataa ggagatgaac 660
agctccaatc tgtacatgtc tatgtctagc tggtgctata cacacagtct ggacggagca 720
ggcctgttcc tgtttgatca cgccgccgag gagtatgagc acgccaagaa gctgatcatc 780
tttctgaatg agaacaatgt gcctgtgcag ctgacctcta tcagcgcccc agagcacaag 840
ttcgagggcc tgacacagat ctttcagaag gcctacgagc acgagcagca catctccgag 900
tctatcaaca atatcgtgga ccacgccatc aagtccaagg atcacgccac cttcaacttt 960
ctgcagtggt acgtggccga gcagcacgag gaggaggtgc tgtttaagga catcctggat 1020
aagatcgagc tgatcggcaa tgagaaccac gggctgtatc tggctgacca gtatgtcaag 1080
ggcatcgcaa aatcacgcaa atcataa 1107
<210> 65
<211> 1260
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 65
atggatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 60
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 120
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 180
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 240
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 300
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 360
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 420
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 480
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 540
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 600
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 660
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 720
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga catcatcaag 780
ctgctgaacg agcaagtgaa taaggagatg aacagctcca atctgtacat gtctatgtct 840
agctggtgct atacacacag tctggacgga gcaggcctgt tcctgtttga tcacgccgcc 900
gaggagtatg agcacgccaa gaagctgatc atctttctga atgagaacaa tgtgcctgtg 960
cagctgacct ctatcagcgc cccagagcac aagttcgagg gcctgacaca gatctttcag 1020
aaggcctacg agcacgagca gcacatctcc gagtctatca acaatatcgt ggaccacgcc 1080
atcaagtcca aggatcacgc caccttcaac tttctgcagt ggtacgtggc cgagcagcac 1140
gaggaggagg tgctgtttaa ggacatcctg gataagatcg agctgatcgg caatgagaac 1200
cacgggctgt atctggctga ccagtatgtc aagggcatcg caaaatcacg caaatcataa 1260
<210> 66
<211> 981
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 66
atggatgcag aattccgaca tggaggagga gatgcagaat tccgacatgg aggaggagat 60
gcagaattcc gacatggagg aggagatgca gaattccgac atggaggagg agatgcagaa 120
ttccgacatg gaggaggaga tgcagaattc cgacatggag gaggagatgc agaattccga 180
catggaggag gagatgcaga attccgacat ggaggaggag atgcagaatt ccgacatgga 240
ggaggagatg cagaattccg acatggagga ggagatgcag aattccgaca tggaggagga 300
gatgcagaat tccgacatgg aggaggagat gcagaattcc gacatggagg aggagatgca 360
gaattccgac atggaggagg agatgcagaa ttccgacatg gaggaggaga tgcagaattc 420
cgacatggag gaggagatgc agaattccga catggaggag gagatgcaga attccgacat 480
ggaggaggag acatcatcaa gctgctgaac gagcaagtga ataaggagat gaacagctcc 540
aatctgtaca tgtctatgtc tagctggtgc tatacacaca gtctggacgg agcaggcctg 600
ttcctgtttg atcacgccgc cgaggagtat gagcacgcca agaagctgat catctttctg 660
aatgagaaca atgtgcctgt gcagctgacc tctatcagcg ccccagagca caagttcgag 720
ggcctgacac agatctttca gaaggcctac gagcacgagc agcacatctc cgagtctatc 780
aacaatatcg tggaccacgc catcaagtcc aaggatcacg ccaccttcaa ctttctgcag 840
tggtacgtgg ccgagcagca cgaggaggag gtgctgttta aggacatcct ggataagatc 900
gagctgatcg gcaatgagaa ccacgggctg tatctggctg accagtatgt caagggcatc 960
gcaaaatcac gcaaatcata a 981
<210> 67
<211> 1143
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 67
atggatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 60
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 120
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 180
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 240
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 300
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 360
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 420
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 480
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 540
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 600
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agacatcatc 660
aagctgctga acgagcaagt gaataaggag atgaacagct ccaatctgta catgtctatg 720
tctagctggt gctatacaca cagtctggac ggagcaggcc tgttcctgtt tgatcacgcc 780
gccgaggagt atgagcacgc caagaagctg atcatctttc tgaatgagaa caatgtgcct 840
gtgcagctga cctctatcag cgccccagag cacaagttcg agggcctgac acagatcttt 900
cagaaggcct acgagcacga gcagcacatc tccgagtcta tcaacaatat cgtggaccac 960
gccatcaagt ccaaggatca cgccaccttc aactttctgc agtggtacgt ggccgagcag 1020
cacgaggagg aggtgctgtt taaggacatc ctggataaga tcgagctgat cggcaatgag 1080
aaccacgggc tgtatctggc tgaccagtat gtcaagggca tcgcaaaatc acgcaaatca 1140
taa 1143
<210> 68
<211> 1305
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 68
atggatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 60
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 120
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 180
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 240
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 300
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 360
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 420
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 480
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 540
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 600
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 660
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 720
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 780
cgacatgact caggatatga agttggagga ggagacatca tcaagctgct gaacgagcaa 840
gtgaataagg agatgaacag ctccaatctg tacatgtcta tgtctagctg gtgctataca 900
cacagtctgg acggagcagg cctgttcctg tttgatcacg ccgccgagga gtatgagcac 960
gccaagaagc tgatcatctt tctgaatgag aacaatgtgc ctgtgcagct gacctctatc 1020
agcgccccag agcacaagtt cgagggcctg acacagatct ttcagaaggc ctacgagcac 1080
gagcagcaca tctccgagtc tatcaacaat atcgtggacc acgccatcaa gtccaaggat 1140
cacgccacct tcaactttct gcagtggtac gtggccgagc agcacgagga ggaggtgctg 1200
tttaaggaca tcctggataa gatcgagctg atcggcaatg agaaccacgg gctgtatctg 1260
gctgaccagt atgtcaaggg catcgcaaaa tcacgcaaat cataa 1305
<210> 69
<211> 1008
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 69
atggatgcag aattccgaca tggaggagga gatgcagaat tccgacatgg aggaggagat 60
gcagaattcc gacatggagg aggagatgca gaattccgac atggaggagg agatgcagaa 120
ttccgacatg gaggaggaga tgcagaattc cgacatggag gaggagatgc agaattccga 180
catggaggag gagatgcaga attccgacat ggaggaggag atgcagaatt ccgacatgga 240
ggaggagatg cagaattccg acatggagga ggagatgcag aattccgaca tggaggagga 300
gatgcagaat tccgacatgg aggaggagat gcagaattcc gacatggagg aggagatgca 360
gaattccgac atggaggagg agatgcagaa ttccgacatg gaggaggaga tgcagaattc 420
cgacatggag gaggagatgc agaattccga catggaggag gagatgcaga attccgacat 480
ggaggaggag atgcagaatt ccgacatgga ggaggagaca tcatcaagct gctgaacgag 540
caagtgaata aggagatgaa cagctccaat ctgtacatgt ctatgtctag ctggtgctat 600
acacacagtc tggacggagc aggcctgttc ctgtttgatc acgccgccga ggagtatgag 660
cacgccaaga agctgatcat ctttctgaat gagaacaatg tgcctgtgca gctgacctct 720
atcagcgccc cagagcacaa gttcgagggc ctgacacaga tctttcagaa ggcctacgag 780
cacgagcagc acatctccga gtctatcaac aatatcgtgg accacgccat caagtccaag 840
gatcacgcca ccttcaactt tctgcagtgg tacgtggccg agcagcacga ggaggaggtg 900
ctgtttaagg acatcctgga taagatcgag ctgatcggca atgagaacca cgggctgtat 960
ctggctgacc agtatgtcaa gggcatcgca aaatcacgca aatcataa 1008
<210> 70
<211> 1179
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 70
atggatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 60
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 120
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 180
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 240
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 300
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 360
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 420
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 480
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 540
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 600
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 660
ttccgacatg actcaggagg aggaggagac atcatcaagc tgctgaacga gcaagtgaat 720
aaggagatga acagctccaa tctgtacatg tctatgtcta gctggtgcta tacacacagt 780
ctggacggag caggcctgtt cctgtttgat cacgccgccg aggagtatga gcacgccaag 840
aagctgatca tctttctgaa tgagaacaat gtgcctgtgc agctgacctc tatcagcgcc 900
ccagagcaca agttcgaggg cctgacacag atctttcaga aggcctacga gcacgagcag 960
cacatctccg agtctatcaa caatatcgtg gaccacgcca tcaagtccaa ggatcacgcc 1020
accttcaact ttctgcagtg gtacgtggcc gagcagcacg aggaggaggt gctgtttaag 1080
gacatcctgg ataagatcga gctgatcggc aatgagaacc acgggctgta tctggctgac 1140
cagtatgtca agggcatcgc aaaatcacgc aaatcataa 1179
<210> 72
<211> 1350
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 72
atggatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 60
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 120
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 180
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 240
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 300
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 360
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 420
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 480
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 540
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 600
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 660
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 720
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 780
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 840
tatgaagttg gaggaggaga catcatcaag ctgctgaacg agcaagtgaa taaggagatg 900
aacagctcca atctgtacat gtctatgtct agctggtgct atacacacag tctggacgga 960
gcaggcctgt tcctgtttga tcacgccgcc gaggagtatg agcacgccaa gaagctgatc 1020
atctttctga atgagaacaa tgtgcctgtg cagctgacct ctatcagcgc cccagagcac 1080
aagttcgagg gcctgacaca gatctttcag aaggcctacg agcacgagca gcacatctcc 1140
gagtctatca acaatatcgt ggaccacgcc atcaagtcca aggatcacgc caccttcaac 1200
tttctgcagt ggtacgtggc cgagcagcac gaggaggagg tgctgtttaa ggacatcctg 1260
gataagatcg agctgatcgg caatgagaac cacgggctgt atctggctga ccagtatgtc 1320
aagggcatcg caaaatcacg caaatcataa 1350
<210> 72
<211> 1035
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 72
atggatgcag aattccgaca tggaggagga gatgcagaat tccgacatgg aggaggagat 60
gcagaattcc gacatggagg aggagatgca gaattccgac atggaggagg agatgcagaa 120
ttccgacatg gaggaggaga tgcagaattc cgacatggag gaggagatgc agaattccga 180
catggaggag gagatgcaga attccgacat ggaggaggag atgcagaatt ccgacatgga 240
ggaggagatg cagaattccg acatggagga ggagatgcag aattccgaca tggaggagga 300
gatgcagaat tccgacatgg aggaggagat gcagaattcc gacatggagg aggagatgca 360
gaattccgac atggaggagg agatgcagaa ttccgacatg gaggaggaga tgcagaattc 420
cgacatggag gaggagatgc agaattccga catggaggag gagatgcaga attccgacat 480
ggaggaggag atgcagaatt ccgacatgga ggaggagatg cagaattccg acatggagga 540
ggagacatca tcaagctgct gaacgagcaa gtgaataagg agatgaacag ctccaatctg 600
tacatgtcta tgtctagctg gtgctataca cacagtctgg acggagcagg cctgttcctg 660
tttgatcacg ccgccgagga gtatgagcac gccaagaagc tgatcatctt tctgaatgag 720
aacaatgtgc ctgtgcagct gacctctatc agcgccccag agcacaagtt cgagggcctg 780
acacagatct ttcagaaggc ctacgagcac gagcagcaca tctccgagtc tatcaacaat 840
atcgtggacc acgccatcaa gtccaaggat cacgccacct tcaactttct gcagtggtac 900
gtggccgagc agcacgagga ggaggtgctg tttaaggaca tcctggataa gatcgagctg 960
atcggcaatg agaaccacgg gctgtatctg gctgaccagt atgtcaaggg catcgcaaaa 1020
tcacgcaaat cataa 1035
<210> 73
<211> 1215
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 73
atggatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 60
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 120
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 180
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 240
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 300
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 360
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 420
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 480
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 540
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 600
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 660
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 720
ggagacatca tcaagctgct gaacgagcaa gtgaataagg agatgaacag ctccaatctg 780
tacatgtcta tgtctagctg gtgctataca cacagtctgg acggagcagg cctgttcctg 840
tttgatcacg ccgccgagga gtatgagcac gccaagaagc tgatcatctt tctgaatgag 900
aacaatgtgc ctgtgcagct gacctctatc agcgccccag agcacaagtt cgagggcctg 960
acacagatct ttcagaaggc ctacgagcac gagcagcaca tctccgagtc tatcaacaat 1020
atcgtggacc acgccatcaa gtccaaggat cacgccacct tcaactttct gcagtggtac 1080
gtggccgagc agcacgagga ggaggtgctg tttaaggaca tcctggataa gatcgagctg 1140
atcggcaatg agaaccacgg gctgtatctg gctgaccagt atgtcaaggg catcgcaaaa 1200
tcacgcaaat cataa 1215
<210> 74
<211> 1395
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 74
atggatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 60
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 120
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 180
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 240
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 300
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 360
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 420
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 480
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 540
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 600
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 660
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 720
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 780
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 840
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 900
ggagacatca tcaagctgct gaacgagcaa gtgaataagg agatgaacag ctccaatctg 960
tacatgtcta tgtctagctg gtgctataca cacagtctgg acggagcagg cctgttcctg 1020
tttgatcacg ccgccgagga gtatgagcac gccaagaagc tgatcatctt tctgaatgag 1080
aacaatgtgc ctgtgcagct gacctctatc agcgccccag agcacaagtt cgagggcctg 1140
acacagatct ttcagaaggc ctacgagcac gagcagcaca tctccgagtc tatcaacaat 1200
atcgtggacc acgccatcaa gtccaaggat cacgccacct tcaactttct gcagtggtac 1260
gtggccgagc agcacgagga ggaggtgctg tttaaggaca tcctggataa gatcgagctg 1320
atcggcaatg agaaccacgg gctgtatctg gctgaccagt atgtcaaggg catcgcaaaa 1380
tcacgcaaat cataa 1395
<210> 75
<211> 1062
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 75
atggatgcag aattccgaca tggaggagga gatgcagaat tccgacatgg aggaggagat 60
gcagaattcc gacatggagg aggagatgca gaattccgac atggaggagg agatgcagaa 120
ttccgacatg gaggaggaga tgcagaattc cgacatggag gaggagatgc agaattccga 180
catggaggag gagatgcaga attccgacat ggaggaggag atgcagaatt ccgacatgga 240
ggaggagatg cagaattccg acatggagga ggagatgcag aattccgaca tggaggagga 300
gatgcagaat tccgacatgg aggaggagat gcagaattcc gacatggagg aggagatgca 360
gaattccgac atggaggagg agatgcagaa ttccgacatg gaggaggaga tgcagaattc 420
cgacatggag gaggagatgc agaattccga catggaggag gagatgcaga attccgacat 480
ggaggaggag atgcagaatt ccgacatgga ggaggagatg cagaattccg acatggagga 540
ggagatgcag aattccgaca tggaggagga gacatcatca agctgctgaa cgagcaagtg 600
aataaggaga tgaacagctc caatctgtac atgtctatgt ctagctggtg ctatacacac 660
agtctggacg gagcaggcct gttcctgttt gatcacgccg ccgaggagta tgagcacgcc 720
aagaagctga tcatctttct gaatgagaac aatgtgcctg tgcagctgac ctctatcagc 780
gccccagagc acaagttcga gggcctgaca cagatctttc agaaggccta cgagcacgag 840
cagcacatct ccgagtctat caacaatatc gtggaccacg ccatcaagtc caaggatcac 900
gccaccttca actttctgca gtggtacgtg gccgagcagc acgaggagga ggtgctgttt 960
aaggacatcc tggataagat cgagctgatc ggcaatgaga accacgggct gtatctggct 1020
gaccagtatg tcaagggcat cgcaaaatca cgcaaatcat aa 1062
<210> 76
<211> 1251
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 76
atggatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 60
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 120
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 180
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 240
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 300
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 360
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 420
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 480
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 540
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 600
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 660
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 720
ggagatgcag aattccgaca tgactcagga ggaggaggag acatcatcaa gctgctgaac 780
gagcaagtga ataaggagat gaacagctcc aatctgtaca tgtctatgtc tagctggtgc 840
tatacacaca gtctggacgg agcaggcctg ttcctgtttg atcacgccgc cgaggagtat 900
gagcacgcca agaagctgat catctttctg aatgagaaca atgtgcctgt gcagctgacc 960
tctatcagcg ccccagagca caagttcgag ggcctgacac agatctttca gaaggcctac 1020
gagcacgagc agcacatctc cgagtctatc aacaatatcg tggaccacgc catcaagtcc 1080
aaggatcacg ccaccttcaa ctttctgcag tggtacgtgg ccgagcagca cgaggaggag 1140
gtgctgttta aggacatcct ggataagatc gagctgatcg gcaatgagaa ccacgggctg 1200
tatctggctg accagtatgt caagggcatc gcaaaatcac gcaaatcata a 1251
<210> 77
<211> 1440
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 77
atggatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 60
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 120
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 180
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 240
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 300
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 360
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 420
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 480
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 540
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 600
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 660
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 720
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 780
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 840
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 900
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga catcatcaag 960
ctgctgaacg agcaagtgaa taaggagatg aacagctcca atctgtacat gtctatgtct 1020
agctggtgct atacacacag tctggacgga gcaggcctgt tcctgtttga tcacgccgcc 1080
gaggagtatg agcacgccaa gaagctgatc atctttctga atgagaacaa tgtgcctgtg 1140
cagctgacct ctatcagcgc cccagagcac aagttcgagg gcctgacaca gatctttcag 1200
aaggcctacg agcacgagca gcacatctcc gagtctatca acaatatcgt ggaccacgcc 1260
atcaagtcca aggatcacgc caccttcaac tttctgcagt ggtacgtggc cgagcagcac 1320
gaggaggagg tgctgtttaa ggacatcctg gataagatcg agctgatcgg caatgagaac 1380
cacgggctgt atctggctga ccagtatgtc aagggcatcg caaaatcacg caaatcataa 1440
<210> 78
<211> 1089
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 78
atggatgcag aattccgaca tggaggagga gatgcagaat tccgacatgg aggaggagat 60
gcagaattcc gacatggagg aggagatgca gaattccgac atggaggagg agatgcagaa 120
ttccgacatg gaggaggaga tgcagaattc cgacatggag gaggagatgc agaattccga 180
catggaggag gagatgcaga attccgacat ggaggaggag atgcagaatt ccgacatgga 240
ggaggagatg cagaattccg acatggagga ggagatgcag aattccgaca tggaggagga 300
gatgcagaat tccgacatgg aggaggagat gcagaattcc gacatggagg aggagatgca 360
gaattccgac atggaggagg agatgcagaa ttccgacatg gaggaggaga tgcagaattc 420
cgacatggag gaggagatgc agaattccga catggaggag gagatgcaga attccgacat 480
ggaggaggag atgcagaatt ccgacatgga ggaggagatg cagaattccg acatggagga 540
ggagatgcag aattccgaca tggaggagga gatgcagaat tccgacatgg aggaggagac 600
atcatcaagc tgctgaacga gcaagtgaat aaggagatga acagctccaa tctgtacatg 660
tctatgtcta gctggtgcta tacacacagt ctggacggag caggcctgtt cctgtttgat 720
cacgccgccg aggagtatga gcacgccaag aagctgatca tctttctgaa tgagaacaat 780
gtgcctgtgc agctgacctc tatcagcgcc ccagagcaca agttcgaggg cctgacacag 840
atctttcaga aggcctacga gcacgagcag cacatctccg agtctatcaa caatatcgtg 900
gaccacgcca tcaagtccaa ggatcacgcc accttcaact ttctgcagtg gtacgtggcc 960
gagcagcacg aggaggaggt gctgtttaag gacatcctgg ataagatcga gctgatcggc 1020
aatgagaacc acgggctgta tctggctgac cagtatgtca agggcatcgc aaaatcacgc 1080
aaatcataa 1089
<210> 79
<211> 1287
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 79
atggatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 60
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 120
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 180
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 240
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 300
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 360
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 420
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 480
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 540
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 600
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 660
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 720
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 780
tcaggaggag gaggagacat catcaagctg ctgaacgagc aagtgaataa ggagatgaac 840
agctccaatc tgtacatgtc tatgtctagc tggtgctata cacacagtct ggacggagca 900
ggcctgttcc tgtttgatca cgccgccgag gagtatgagc acgccaagaa gctgatcatc 960
tttctgaatg agaacaatgt gcctgtgcag ctgacctcta tcagcgcccc agagcacaag 1020
ttcgagggcc tgacacagat ctttcagaag gcctacgagc acgagcagca catctccgag 1080
tctatcaaca atatcgtgga ccacgccatc aagtccaagg atcacgccac cttcaacttt 1140
ctgcagtggt acgtggccga gcagcacgag gaggaggtgc tgtttaagga catcctggat 1200
aagatcgagc tgatcggcaa tgagaaccac gggctgtatc tggctgacca gtatgtcaag 1260
ggcatcgcaa aatcacgcaa atcataa 1287
<210> 80
<211> 1485
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 80
atggatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 60
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 120
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 180
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 240
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 300
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 360
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 420
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 480
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 540
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 600
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 660
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 720
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 780
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 840
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 900
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 960
cgacatgact caggatatga agttggagga ggagacatca tcaagctgct gaacgagcaa 1020
gtgaataagg agatgaacag ctccaatctg tacatgtcta tgtctagctg gtgctataca 1080
cacagtctgg acggagcagg cctgttcctg tttgatcacg ccgccgagga gtatgagcac 1140
gccaagaagc tgatcatctt tctgaatgag aacaatgtgc ctgtgcagct gacctctatc 1200
agcgccccag agcacaagtt cgagggcctg acacagatct ttcagaaggc ctacgagcac 1260
gagcagcaca tctccgagtc tatcaacaat atcgtggacc acgccatcaa gtccaaggat 1320
cacgccacct tcaactttct gcagtggtac gtggccgagc agcacgagga ggaggtgctg 1380
tttaaggaca tcctggataa gatcgagctg atcggcaatg agaaccacgg gctgtatctg 1440
gctgaccagt atgtcaaggg catcgcaaaa tcacgcaaat cataa 1485
<210> 81
<211> 1116
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 81
atggatgcag aattccgaca tggaggagga gatgcagaat tccgacatgg aggaggagat 60
gcagaattcc gacatggagg aggagatgca gaattccgac atggaggagg agatgcagaa 120
ttccgacatg gaggaggaga tgcagaattc cgacatggag gaggagatgc agaattccga 180
catggaggag gagatgcaga attccgacat ggaggaggag atgcagaatt ccgacatgga 240
ggaggagatg cagaattccg acatggagga ggagatgcag aattccgaca tggaggagga 300
gatgcagaat tccgacatgg aggaggagat gcagaattcc gacatggagg aggagatgca 360
gaattccgac atggaggagg agatgcagaa ttccgacatg gaggaggaga tgcagaattc 420
cgacatggag gaggagatgc agaattccga catggaggag gagatgcaga attccgacat 480
ggaggaggag atgcagaatt ccgacatgga ggaggagatg cagaattccg acatggagga 540
ggagatgcag aattccgaca tggaggagga gatgcagaat tccgacatgg aggaggagat 600
gcagaattcc gacatggagg aggagacatc atcaagctgc tgaacgagca agtgaataag 660
gagatgaaca gctccaatct gtacatgtct atgtctagct ggtgctatac acacagtctg 720
gacggagcag gcctgttcct gtttgatcac gccgccgagg agtatgagca cgccaagaag 780
ctgatcatct ttctgaatga gaacaatgtg cctgtgcagc tgacctctat cagcgcccca 840
gagcacaagt tcgagggcct gacacagatc tttcagaagg cctacgagca cgagcagcac 900
atctccgagt ctatcaacaa tatcgtggac cacgccatca agtccaagga tcacgccacc 960
ttcaactttc tgcagtggta cgtggccgag cagcacgagg aggaggtgct gtttaaggac 1020
atcctggata agatcgagct gatcggcaat gagaaccacg ggctgtatct ggctgaccag 1080
tatgtcaagg gcatcgcaaa atcacgcaaa tcataa 1116
<210> 82
<211> 1323
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 82
atggatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 60
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 120
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 180
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 240
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 300
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 360
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 420
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 480
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 540
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 600
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 660
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 720
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 780
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agacatcatc 840
aagctgctga acgagcaagt gaataaggag atgaacagct ccaatctgta catgtctatg 900
tctagctggt gctatacaca cagtctggac ggagcaggcc tgttcctgtt tgatcacgcc 960
gccgaggagt atgagcacgc caagaagctg atcatctttc tgaatgagaa caatgtgcct 1020
gtgcagctga cctctatcag cgccccagag cacaagttcg agggcctgac acagatcttt 1080
cagaaggcct acgagcacga gcagcacatc tccgagtcta tcaacaatat cgtggaccac 1140
gccatcaagt ccaaggatca cgccaccttc aactttctgc agtggtacgt ggccgagcag 1200
cacgaggagg aggtgctgtt taaggacatc ctggataaga tcgagctgat cggcaatgag 1260
aaccacgggc tgtatctggc tgaccagtat gtcaagggca tcgcaaaatc acgcaaatca 1320
taa 1323
<210> 83
<211> 1530
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 83
atggatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 60
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 120
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 180
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 240
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 300
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 360
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 420
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 480
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 540
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 600
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 660
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 720
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 780
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 840
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 900
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 960
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 1020
tatgaagttg gaggaggaga catcatcaag ctgctgaacg agcaagtgaa taaggagatg 1080
aacagctcca atctgtacat gtctatgtct agctggtgct atacacacag tctggacgga 1140
gcaggcctgt tcctgtttga tcacgccgcc gaggagtatg agcacgccaa gaagctgatc 1200
atctttctga atgagaacaa tgtgcctgtg cagctgacct ctatcagcgc cccagagcac 1260
aagttcgagg gcctgacaca gatctttcag aaggcctacg agcacgagca gcacatctcc 1320
gagtctatca acaatatcgt ggaccacgcc atcaagtcca aggatcacgc caccttcaac 1380
tttctgcagt ggtacgtggc cgagcagcac gaggaggagg tgctgtttaa ggacatcctg 1440
gataagatcg agctgatcgg caatgagaac cacgggctgt atctggctga ccagtatgtc 1500
aagggcatcg caaaatcacg caaatcataa 1530
<210> 84
<211> 1143
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 84
atggatgcag aattccgaca tggaggagga gatgcagaat tccgacatgg aggaggagat 60
gcagaattcc gacatggagg aggagatgca gaattccgac atggaggagg agatgcagaa 120
ttccgacatg gaggaggaga tgcagaattc cgacatggag gaggagatgc agaattccga 180
catggaggag gagatgcaga attccgacat ggaggaggag atgcagaatt ccgacatgga 240
ggaggagatg cagaattccg acatggagga ggagatgcag aattccgaca tggaggagga 300
gatgcagaat tccgacatgg aggaggagat gcagaattcc gacatggagg aggagatgca 360
gaattccgac atggaggagg agatgcagaa ttccgacatg gaggaggaga tgcagaattc 420
cgacatggag gaggagatgc agaattccga catggaggag gagatgcaga attccgacat 480
ggaggaggag atgcagaatt ccgacatgga ggaggagatg cagaattccg acatggagga 540
ggagatgcag aattccgaca tggaggagga gatgcagaat tccgacatgg aggaggagat 600
gcagaattcc gacatggagg aggagatgca gaattccgac atggaggagg agacatcatc 660
aagctgctga acgagcaagt gaataaggag atgaacagct ccaatctgta catgtctatg 720
tctagctggt gctatacaca cagtctggac ggagcaggcc tgttcctgtt tgatcacgcc 780
gccgaggagt atgagcacgc caagaagctg atcatctttc tgaatgagaa caatgtgcct 840
gtgcagctga cctctatcag cgccccagag cacaagttcg agggcctgac acagatcttt 900
cagaaggcct acgagcacga gcagcacatc tccgagtcta tcaacaatat cgtggaccac 960
gccatcaagt ccaaggatca cgccaccttc aactttctgc agtggtacgt ggccgagcag 1020
cacgaggagg aggtgctgtt taaggacatc ctggataaga tcgagctgat cggcaatgag 1080
aaccacgggc tgtatctggc tgaccagtat gtcaagggca tcgcaaaatc acgcaaatca 1140
taa 1143
<210> 85
<211> 1359
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 85
atggatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 60
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 120
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 180
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 240
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 300
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 360
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 420
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 480
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 540
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 600
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 660
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 720
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 780
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 840
ttccgacatg actcaggagg aggaggagac atcatcaagc tgctgaacga gcaagtgaat 900
aaggagatga acagctccaa tctgtacatg tctatgtcta gctggtgcta tacacacagt 960
ctggacggag caggcctgtt cctgtttgat cacgccgccg aggagtatga gcacgccaag 1020
aagctgatca tctttctgaa tgagaacaat gtgcctgtgc agctgacctc tatcagcgcc 1080
ccagagcaca agttcgaggg cctgacacag atctttcaga aggcctacga gcacgagcag 1140
cacatctccg agtctatcaa caatatcgtg gaccacgcca tcaagtccaa ggatcacgcc 1200
accttcaact ttctgcagtg gtacgtggcc gagcagcacg aggaggaggt gctgtttaag 1260
gacatcctgg ataagatcga gctgatcggc aatgagaacc acgggctgta tctggctgac 1320
cagtatgtca agggcatcgc aaaatcacgc aaatcataa 1359
<210> 86
<211> 1575
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 86
atggatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 60
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 120
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 180
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 240
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 300
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 360
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 420
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 480
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 540
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 600
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 660
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 720
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 780
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 840
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 900
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 960
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 1020
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 1080
ggagacatca tcaagctgct gaacgagcaa gtgaataagg agatgaacag ctccaatctg 1140
tacatgtcta tgtctagctg gtgctataca cacagtctgg acggagcagg cctgttcctg 1200
tttgatcacg ccgccgagga gtatgagcac gccaagaagc tgatcatctt tctgaatgag 1260
aacaatgtgc ctgtgcagct gacctctatc agcgccccag agcacaagtt cgagggcctg 1320
acacagatct ttcagaaggc ctacgagcac gagcagcaca tctccgagtc tatcaacaat 1380
atcgtggacc acgccatcaa gtccaaggat cacgccacct tcaactttct gcagtggtac 1440
gtggccgagc agcacgagga ggaggtgctg tttaaggaca tcctggataa gatcgagctg 1500
atcggcaatg agaaccacgg gctgtatctg gctgaccagt atgtcaaggg catcgcaaaa 1560
tcacgcaaat cataa 1575
<210> 87
<211> 1170
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 87
atggatgcag aattccgaca tggaggagga gatgcagaat tccgacatgg aggaggagat 60
gcagaattcc gacatggagg aggagatgca gaattccgac atggaggagg agatgcagaa 120
ttccgacatg gaggaggaga tgcagaattc cgacatggag gaggagatgc agaattccga 180
catggaggag gagatgcaga attccgacat ggaggaggag atgcagaatt ccgacatgga 240
ggaggagatg cagaattccg acatggagga ggagatgcag aattccgaca tggaggagga 300
gatgcagaat tccgacatgg aggaggagat gcagaattcc gacatggagg aggagatgca 360
gaattccgac atggaggagg agatgcagaa ttccgacatg gaggaggaga tgcagaattc 420
cgacatggag gaggagatgc agaattccga catggaggag gagatgcaga attccgacat 480
ggaggaggag atgcagaatt ccgacatgga ggaggagatg cagaattccg acatggagga 540
ggagatgcag aattccgaca tggaggagga gatgcagaat tccgacatgg aggaggagat 600
gcagaattcc gacatggagg aggagatgca gaattccgac atggaggagg agatgcagaa 660
ttccgacatg gaggaggaga catcatcaag ctgctgaacg agcaagtgaa taaggagatg 720
aacagctcca atctgtacat gtctatgtct agctggtgct atacacacag tctggacgga 780
gcaggcctgt tcctgtttga tcacgccgcc gaggagtatg agcacgccaa gaagctgatc 840
atctttctga atgagaacaa tgtgcctgtg cagctgacct ctatcagcgc cccagagcac 900
aagttcgagg gcctgacaca gatctttcag aaggcctacg agcacgagca gcacatctcc 960
gagtctatca acaatatcgt ggaccacgcc atcaagtcca aggatcacgc caccttcaac 1020
tttctgcagt ggtacgtggc cgagcagcac gaggaggagg tgctgtttaa ggacatcctg 1080
gataagatcg agctgatcgg caatgagaac cacgggctgt atctggctga ccagtatgtc 1140
aagggcatcg caaaatcacg caaatcataa 1170
<210> 88
<211> 1395
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 88
atggatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 60
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 120
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 180
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 240
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 300
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 360
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 420
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 480
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 540
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 600
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 660
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 720
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 780
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 840
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 900
ggagacatca tcaagctgct gaacgagcaa gtgaataagg agatgaacag ctccaatctg 960
tacatgtcta tgtctagctg gtgctataca cacagtctgg acggagcagg cctgttcctg 1020
tttgatcacg ccgccgagga gtatgagcac gccaagaagc tgatcatctt tctgaatgag 1080
aacaatgtgc ctgtgcagct gacctctatc agcgccccag agcacaagtt cgagggcctg 1140
acacagatct ttcagaaggc ctacgagcac gagcagcaca tctccgagtc tatcaacaat 1200
atcgtggacc acgccatcaa gtccaaggat cacgccacct tcaactttct gcagtggtac 1260
gtggccgagc agcacgagga ggaggtgctg tttaaggaca tcctggataa gatcgagctg 1320
atcggcaatg agaaccacgg gctgtatctg gctgaccagt atgtcaaggg catcgcaaaa 1380
tcacgcaaat cataa 1395
<210> 89
<211> 1620
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 89
atggatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 60
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 120
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 180
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 240
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 300
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 360
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 420
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 480
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 540
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 600
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 660
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 720
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 780
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 840
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 900
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 960
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 1020
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 1080
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga catcatcaag 1140
ctgctgaacg agcaagtgaa taaggagatg aacagctcca atctgtacat gtctatgtct 1200
agctggtgct atacacacag tctggacgga gcaggcctgt tcctgtttga tcacgccgcc 1260
gaggagtatg agcacgccaa gaagctgatc atctttctga atgagaacaa tgtgcctgtg 1320
cagctgacct ctatcagcgc cccagagcac aagttcgagg gcctgacaca gatctttcag 1380
aaggcctacg agcacgagca gcacatctcc gagtctatca acaatatcgt ggaccacgcc 1440
atcaagtcca aggatcacgc caccttcaac tttctgcagt ggtacgtggc cgagcagcac 1500
gaggaggagg tgctgtttaa ggacatcctg gataagatcg agctgatcgg caatgagaac 1560
cacgggctgt atctggctga ccagtatgtc aagggcatcg caaaatcacg caaatcataa 1620
<210> 90
<211> 1197
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 90
atggatgcag aattccgaca tggaggagga gatgcagaat tccgacatgg aggaggagat 60
gcagaattcc gacatggagg aggagatgca gaattccgac atggaggagg agatgcagaa 120
ttccgacatg gaggaggaga tgcagaattc cgacatggag gaggagatgc agaattccga 180
catggaggag gagatgcaga attccgacat ggaggaggag atgcagaatt ccgacatgga 240
ggaggagatg cagaattccg acatggagga ggagatgcag aattccgaca tggaggagga 300
gatgcagaat tccgacatgg aggaggagat gcagaattcc gacatggagg aggagatgca 360
gaattccgac atggaggagg agatgcagaa ttccgacatg gaggaggaga tgcagaattc 420
cgacatggag gaggagatgc agaattccga catggaggag gagatgcaga attccgacat 480
ggaggaggag atgcagaatt ccgacatgga ggaggagatg cagaattccg acatggagga 540
ggagatgcag aattccgaca tggaggagga gatgcagaat tccgacatgg aggaggagat 600
gcagaattcc gacatggagg aggagatgca gaattccgac atggaggagg agatgcagaa 660
ttccgacatg gaggaggaga tgcagaattc cgacatggag gaggagacat catcaagctg 720
ctgaacgagc aagtgaataa ggagatgaac agctccaatc tgtacatgtc tatgtctagc 780
tggtgctata cacacagtct ggacggagca ggcctgttcc tgtttgatca cgccgccgag 840
gagtatgagc acgccaagaa gctgatcatc tttctgaatg agaacaatgt gcctgtgcag 900
ctgacctcta tcagcgcccc agagcacaag ttcgagggcc tgacacagat ctttcagaag 960
gcctacgagc acgagcagca catctccgag tctatcaaca atatcgtgga ccacgccatc 1020
aagtccaagg atcacgccac cttcaacttt ctgcagtggt acgtggccga gcagcacgag 1080
gaggaggtgc tgtttaagga catcctggat aagatcgagc tgatcggcaa tgagaaccac 1140
gggctgtatc tggctgacca gtatgtcaag ggcatcgcaa aatcacgcaa atcataa 1197
<210> 91
<211> 1431
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 91
atggatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 60
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 120
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 180
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 240
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 300
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 360
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 420
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 480
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 540
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 600
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 660
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 720
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 780
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 840
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 900
ggagatgcag aattccgaca tgactcagga ggaggaggag acatcatcaa gctgctgaac 960
gagcaagtga ataaggagat gaacagctcc aatctgtaca tgtctatgtc tagctggtgc 1020
tatacacaca gtctggacgg agcaggcctg ttcctgtttg atcacgccgc cgaggagtat 1080
gagcacgcca agaagctgat catctttctg aatgagaaca atgtgcctgt gcagctgacc 1140
tctatcagcg ccccagagca caagttcgag ggcctgacac agatctttca gaaggcctac 1200
gagcacgagc agcacatctc cgagtctatc aacaatatcg tggaccacgc catcaagtcc 1260
aaggatcacg ccaccttcaa ctttctgcag tggtacgtgg ccgagcagca cgaggaggag 1320
gtgctgttta aggacatcct ggataagatc gagctgatcg gcaatgagaa ccacgggctg 1380
tatctggctg accagtatgt caagggcatc gcaaaatcac gcaaatcata a 1431
<210> 92
<211> 1665
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 92
atggatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 60
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 120
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 180
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 240
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 300
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 360
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 420
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 480
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 540
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 600
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 660
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 720
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 780
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 840
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 900
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 960
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 1020
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 1080
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 1140
cgacatgact caggatatga agttggagga ggagacatca tcaagctgct gaacgagcaa 1200
gtgaataagg agatgaacag ctccaatctg tacatgtcta tgtctagctg gtgctataca 1260
cacagtctgg acggagcagg cctgttcctg tttgatcacg ccgccgagga gtatgagcac 1320
gccaagaagc tgatcatctt tctgaatgag aacaatgtgc ctgtgcagct gacctctatc 1380
agcgccccag agcacaagtt cgagggcctg acacagatct ttcagaaggc ctacgagcac 1440
gagcagcaca tctccgagtc tatcaacaat atcgtggacc acgccatcaa gtccaaggat 1500
cacgccacct tcaactttct gcagtggtac gtggccgagc agcacgagga ggaggtgctg 1560
tttaaggaca tcctggataa gatcgagctg atcggcaatg agaaccacgg gctgtatctg 1620
gctgaccagt atgtcaaggg catcgcaaaa tcacgcaaat cataa 1665
<210> 93
<211> 1224
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 93
atggatgcag aattccgaca tggaggagga gatgcagaat tccgacatgg aggaggagat 60
gcagaattcc gacatggagg aggagatgca gaattccgac atggaggagg agatgcagaa 120
ttccgacatg gaggaggaga tgcagaattc cgacatggag gaggagatgc agaattccga 180
catggaggag gagatgcaga attccgacat ggaggaggag atgcagaatt ccgacatgga 240
ggaggagatg cagaattccg acatggagga ggagatgcag aattccgaca tggaggagga 300
gatgcagaat tccgacatgg aggaggagat gcagaattcc gacatggagg aggagatgca 360
gaattccgac atggaggagg agatgcagaa ttccgacatg gaggaggaga tgcagaattc 420
cgacatggag gaggagatgc agaattccga catggaggag gagatgcaga attccgacat 480
ggaggaggag atgcagaatt ccgacatgga ggaggagatg cagaattccg acatggagga 540
ggagatgcag aattccgaca tggaggagga gatgcagaat tccgacatgg aggaggagat 600
gcagaattcc gacatggagg aggagatgca gaattccgac atggaggagg agatgcagaa 660
ttccgacatg gaggaggaga tgcagaattc cgacatggag gaggagatgc agaattccga 720
catggaggag gagacatcat caagctgctg aacgagcaag tgaataagga gatgaacagc 780
tccaatctgt acatgtctat gtctagctgg tgctatacac acagtctgga cggagcaggc 840
ctgttcctgt ttgatcacgc cgccgaggag tatgagcacg ccaagaagct gatcatcttt 900
ctgaatgaga acaatgtgcc tgtgcagctg acctctatca gcgccccaga gcacaagttc 960
gagggcctga cacagatctt tcagaaggcc tacgagcacg agcagcacat ctccgagtct 1020
atcaacaata tcgtggacca cgccatcaag tccaaggatc acgccacctt caactttctg 1080
cagtggtacg tggccgagca gcacgaggag gaggtgctgt ttaaggacat cctggataag 1140
atcgagctga tcggcaatga gaaccacggg ctgtatctgg ctgaccagta tgtcaagggc 1200
atcgcaaaat cacgcaaatc ataa 1224
<210> 94
<211> 1467
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 94
atggatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 60
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 120
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 180
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 240
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 300
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 360
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 420
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 480
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 540
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 600
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 660
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 720
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 780
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 840
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 900
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 960
tcaggaggag gaggagacat catcaagctg ctgaacgagc aagtgaataa ggagatgaac 1020
agctccaatc tgtacatgtc tatgtctagc tggtgctata cacacagtct ggacggagca 1080
ggcctgttcc tgtttgatca cgccgccgag gagtatgagc acgccaagaa gctgatcatc 1140
tttctgaatg agaacaatgt gcctgtgcag ctgacctcta tcagcgcccc agagcacaag 1200
ttcgagggcc tgacacagat ctttcagaag gcctacgagc acgagcagca catctccgag 1260
tctatcaaca atatcgtgga ccacgccatc aagtccaagg atcacgccac cttcaacttt 1320
ctgcagtggt acgtggccga gcagcacgag gaggaggtgc tgtttaagga catcctggat 1380
aagatcgagc tgatcggcaa tgagaaccac gggctgtatc tggctgacca gtatgtcaag 1440
ggcatcgcaa aatcacgcaa atcataa 1467
<210> 95
<211> 1710
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 95
atggatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 60
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 120
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 180
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 240
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 300
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 360
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 420
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 480
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 540
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 600
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 660
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 720
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 780
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 840
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 900
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 960
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 1020
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 1080
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 1140
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 1200
tatgaagttg gaggaggaga catcatcaag ctgctgaacg agcaagtgaa taaggagatg 1260
aacagctcca atctgtacat gtctatgtct agctggtgct atacacacag tctggacgga 1320
gcaggcctgt tcctgtttga tcacgccgcc gaggagtatg agcacgccaa gaagctgatc 1380
atctttctga atgagaacaa tgtgcctgtg cagctgacct ctatcagcgc cccagagcac 1440
aagttcgagg gcctgacaca gatctttcag aaggcctacg agcacgagca gcacatctcc 1500
gagtctatca acaatatcgt ggaccacgcc atcaagtcca aggatcacgc caccttcaac 1560
tttctgcagt ggtacgtggc cgagcagcac gaggaggagg tgctgtttaa ggacatcctg 1620
gataagatcg agctgatcgg caatgagaac cacgggctgt atctggctga ccagtatgtc 1680
aagggcatcg caaaatcacg caaatcataa 1710
<210> 96
<211> 1251
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 96
atggatgcag aattccgaca tggaggagga gatgcagaat tccgacatgg aggaggagat 60
gcagaattcc gacatggagg aggagatgca gaattccgac atggaggagg agatgcagaa 120
ttccgacatg gaggaggaga tgcagaattc cgacatggag gaggagatgc agaattccga 180
catggaggag gagatgcaga attccgacat ggaggaggag atgcagaatt ccgacatgga 240
ggaggagatg cagaattccg acatggagga ggagatgcag aattccgaca tggaggagga 300
gatgcagaat tccgacatgg aggaggagat gcagaattcc gacatggagg aggagatgca 360
gaattccgac atggaggagg agatgcagaa ttccgacatg gaggaggaga tgcagaattc 420
cgacatggag gaggagatgc agaattccga catggaggag gagatgcaga attccgacat 480
ggaggaggag atgcagaatt ccgacatgga ggaggagatg cagaattccg acatggagga 540
ggagatgcag aattccgaca tggaggagga gatgcagaat tccgacatgg aggaggagat 600
gcagaattcc gacatggagg aggagatgca gaattccgac atggaggagg agatgcagaa 660
ttccgacatg gaggaggaga tgcagaattc cgacatggag gaggagatgc agaattccga 720
catggaggag gagatgcaga attccgacat ggaggaggag acatcatcaa gctgctgaac 780
gagcaagtga ataaggagat gaacagctcc aatctgtaca tgtctatgtc tagctggtgc 840
tatacacaca gtctggacgg agcaggcctg ttcctgtttg atcacgccgc cgaggagtat 900
gagcacgcca agaagctgat catctttctg aatgagaaca atgtgcctgt gcagctgacc 960
tctatcagcg ccccagagca caagttcgag ggcctgacac agatctttca gaaggcctac 1020
gagcacgagc agcacatctc cgagtctatc aacaatatcg tggaccacgc catcaagtcc 1080
aaggatcacg ccaccttcaa ctttctgcag tggtacgtgg ccgagcagca cgaggaggag 1140
gtgctgttta aggacatcct ggataagatc gagctgatcg gcaatgagaa ccacgggctg 1200
tatctggctg accagtatgt caagggcatc gcaaaatcac gcaaatcata a 1251
<210> 97
<211> 1503
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 97
atggatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 60
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 120
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 180
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 240
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 300
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 360
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 420
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 480
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 540
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 600
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 660
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 720
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 780
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 840
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 900
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 960
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agacatcatc 1020
aagctgctga acgagcaagt gaataaggag atgaacagct ccaatctgta catgtctatg 1080
tctagctggt gctatacaca cagtctggac ggagcaggcc tgttcctgtt tgatcacgcc 1140
gccgaggagt atgagcacgc caagaagctg atcatctttc tgaatgagaa caatgtgcct 1200
gtgcagctga cctctatcag cgccccagag cacaagttcg agggcctgac acagatcttt 1260
cagaaggcct acgagcacga gcagcacatc tccgagtcta tcaacaatat cgtggaccac 1320
gccatcaagt ccaaggatca cgccaccttc aactttctgc agtggtacgt ggccgagcag 1380
cacgaggagg aggtgctgtt taaggacatc ctggataaga tcgagctgat cggcaatgag 1440
aaccacgggc tgtatctggc tgaccagtat gtcaagggca tcgcaaaatc acgcaaatca 1500
taa 1503
<210> 98
<211> 1755
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 98
atggatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 60
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 120
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 180
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 240
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 300
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 360
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 420
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 480
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 540
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 600
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 660
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 720
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 780
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 840
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 900
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 960
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 1020
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 1080
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 1140
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 1200
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 1260
ggagacatca tcaagctgct gaacgagcaa gtgaataagg agatgaacag ctccaatctg 1320
tacatgtcta tgtctagctg gtgctataca cacagtctgg acggagcagg cctgttcctg 1380
tttgatcacg ccgccgagga gtatgagcac gccaagaagc tgatcatctt tctgaatgag 1440
aacaatgtgc ctgtgcagct gacctctatc agcgccccag agcacaagtt cgagggcctg 1500
acacagatct ttcagaaggc ctacgagcac gagcagcaca tctccgagtc tatcaacaat 1560
atcgtggacc acgccatcaa gtccaaggat cacgccacct tcaactttct gcagtggtac 1620
gtggccgagc agcacgagga ggaggtgctg tttaaggaca tcctggataa gatcgagctg 1680
atcggcaatg agaaccacgg gctgtatctg gctgaccagt atgtcaaggg catcgcaaaa 1740
tcacgcaaat cataa 1755
<210> 99
<211> 1278
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 99
atggatgcag aattccgaca tggaggagga gatgcagaat tccgacatgg aggaggagat 60
gcagaattcc gacatggagg aggagatgca gaattccgac atggaggagg agatgcagaa 120
ttccgacatg gaggaggaga tgcagaattc cgacatggag gaggagatgc agaattccga 180
catggaggag gagatgcaga attccgacat ggaggaggag atgcagaatt ccgacatgga 240
ggaggagatg cagaattccg acatggagga ggagatgcag aattccgaca tggaggagga 300
gatgcagaat tccgacatgg aggaggagat gcagaattcc gacatggagg aggagatgca 360
gaattccgac atggaggagg agatgcagaa ttccgacatg gaggaggaga tgcagaattc 420
cgacatggag gaggagatgc agaattccga catggaggag gagatgcaga attccgacat 480
ggaggaggag atgcagaatt ccgacatgga ggaggagatg cagaattccg acatggagga 540
ggagatgcag aattccgaca tggaggagga gatgcagaat tccgacatgg aggaggagat 600
gcagaattcc gacatggagg aggagatgca gaattccgac atggaggagg agatgcagaa 660
ttccgacatg gaggaggaga tgcagaattc cgacatggag gaggagatgc agaattccga 720
catggaggag gagatgcaga attccgacat ggaggaggag atgcagaatt ccgacatgga 780
ggaggagaca tcatcaagct gctgaacgag caagtgaata aggagatgaa cagctccaat 840
ctgtacatgt ctatgtctag ctggtgctat acacacagtc tggacggagc aggcctgttc 900
ctgtttgatc acgccgccga ggagtatgag cacgccaaga agctgatcat ctttctgaat 960
gagaacaatg tgcctgtgca gctgacctct atcagcgccc cagagcacaa gttcgagggc 1020
ctgacacaga tctttcagaa ggcctacgag cacgagcagc acatctccga gtctatcaac 1080
aatatcgtgg accacgccat caagtccaag gatcacgcca ccttcaactt tctgcagtgg 1140
tacgtggccg agcagcacga ggaggaggtg ctgtttaagg acatcctgga taagatcgag 1200
ctgatcggca atgagaacca cgggctgtat ctggctgacc agtatgtcaa gggcatcgca 1260
aaatcacgca aatcataa 1278
<210> 100
<211> 1539
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 100
atggatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 60
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 120
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 180
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 240
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 300
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 360
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 420
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 480
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 540
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 600
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 660
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 720
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 780
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 840
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 900
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 960
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 1020
ttccgacatg actcaggagg aggaggagac atcatcaagc tgctgaacga gcaagtgaat 1080
aaggagatga acagctccaa tctgtacatg tctatgtcta gctggtgcta tacacacagt 1140
ctggacggag caggcctgtt cctgtttgat cacgccgccg aggagtatga gcacgccaag 1200
aagctgatca tctttctgaa tgagaacaat gtgcctgtgc agctgacctc tatcagcgcc 1260
ccagagcaca agttcgaggg cctgacacag atctttcaga aggcctacga gcacgagcag 1320
cacatctccg agtctatcaa caatatcgtg gaccacgcca tcaagtccaa ggatcacgcc 1380
accttcaact ttctgcagtg gtacgtggcc gagcagcacg aggaggaggt gctgtttaag 1440
gacatcctgg ataagatcga gctgatcggc aatgagaacc acgggctgta tctggctgac 1500
cagtatgtca agggcatcgc aaaatcacgc aaatcataa 1539
<210> 101
<211> 1800
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 101
atggatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 60
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 120
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 180
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 240
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 300
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 360
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 420
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 480
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 540
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 600
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 660
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 720
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 780
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 840
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 900
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 960
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 1020
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 1080
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 1140
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 1200
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 1260
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga catcatcaag 1320
ctgctgaacg agcaagtgaa taaggagatg aacagctcca atctgtacat gtctatgtct 1380
agctggtgct atacacacag tctggacgga gcaggcctgt tcctgtttga tcacgccgcc 1440
gaggagtatg agcacgccaa gaagctgatc atctttctga atgagaacaa tgtgcctgtg 1500
cagctgacct ctatcagcgc cccagagcac aagttcgagg gcctgacaca gatctttcag 1560
aaggcctacg agcacgagca gcacatctcc gagtctatca acaatatcgt ggaccacgcc 1620
atcaagtcca aggatcacgc caccttcaac tttctgcagt ggtacgtggc cgagcagcac 1680
gaggaggagg tgctgtttaa ggacatcctg gataagatcg agctgatcgg caatgagaac 1740
cacgggctgt atctggctga ccagtatgtc aagggcatcg caaaatcacg caaatcataa 1800
<210> 102
<211> 1305
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 102
atggatgcag aattccgaca tggaggagga gatgcagaat tccgacatgg aggaggagat 60
gcagaattcc gacatggagg aggagatgca gaattccgac atggaggagg agatgcagaa 120
ttccgacatg gaggaggaga tgcagaattc cgacatggag gaggagatgc agaattccga 180
catggaggag gagatgcaga attccgacat ggaggaggag atgcagaatt ccgacatgga 240
ggaggagatg cagaattccg acatggagga ggagatgcag aattccgaca tggaggagga 300
gatgcagaat tccgacatgg aggaggagat gcagaattcc gacatggagg aggagatgca 360
gaattccgac atggaggagg agatgcagaa ttccgacatg gaggaggaga tgcagaattc 420
cgacatggag gaggagatgc agaattccga catggaggag gagatgcaga attccgacat 480
ggaggaggag atgcagaatt ccgacatgga ggaggagatg cagaattccg acatggagga 540
ggagatgcag aattccgaca tggaggagga gatgcagaat tccgacatgg aggaggagat 600
gcagaattcc gacatggagg aggagatgca gaattccgac atggaggagg agatgcagaa 660
ttccgacatg gaggaggaga tgcagaattc cgacatggag gaggagatgc agaattccga 720
catggaggag gagatgcaga attccgacat ggaggaggag atgcagaatt ccgacatgga 780
ggaggagatg cagaattccg acatggagga ggagacatca tcaagctgct gaacgagcaa 840
gtgaataagg agatgaacag ctccaatctg tacatgtcta tgtctagctg gtgctataca 900
cacagtctgg acggagcagg cctgttcctg tttgatcacg ccgccgagga gtatgagcac 960
gccaagaagc tgatcatctt tctgaatgag aacaatgtgc ctgtgcagct gacctctatc 1020
agcgccccag agcacaagtt cgagggcctg acacagatct ttcagaaggc ctacgagcac 1080
gagcagcaca tctccgagtc tatcaacaat atcgtggacc acgccatcaa gtccaaggat 1140
cacgccacct tcaactttct gcagtggtac gtggccgagc agcacgagga ggaggtgctg 1200
tttaaggaca tcctggataa gatcgagctg atcggcaatg agaaccacgg gctgtatctg 1260
gctgaccagt atgtcaaggg catcgcaaaa tcacgcaaat cataa 1305
<210> 103
<211> 1608
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 103
atggatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 60
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 120
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 180
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 240
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 300
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 360
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 420
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 480
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 540
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 600
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 660
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 720
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 780
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 840
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 900
ggagatgcag aattccgaca tgactcagga ggaggaggag atgcagaatt ccgacatgac 960
tcaggaggag gaggagatgc agaattccga catgactcag gaggaggagg agatgcagaa 1020
ttccgacatg actcaggagg aggaggagat gcagaattcc gacatgactc aggaggagga 1080
ggagacatca tcaagctgct gaacgagcaa gtgaatgaca tcatcaagct gctgaacgag 1140
caagtgaata aggagatgaa cagctccaat ctgtacatgt ctatgtctag ctggtgctat 1200
acacacagtc tggacggagc aggcctgttc ctgtttgatc acgccgccga ggagtatgag 1260
cacgccaaga agctgatcat ctttctgaat gagaacaatg tgcctgtgca gctgacctct 1320
atcagcgccc cagagcacaa gttcgagggc ctgacacaga tctttcagaa ggcctacgag 1380
cacgagcagc acatctccga gtctatcaac aatatcgtgg accacgccat caagtccaag 1440
gatcacgcca ccttcaactt tctgcagtgg tacgtggccg agcagcacga ggaggaggtg 1500
ctgtttaagg acatcctgga taagatcgag ctgatcggca atgagaacca cgggctgtat 1560
ctggctgacc agtatgtcaa gggcatcgca aaatcacgca aatcataa 1608
<210> 104
<211> 1845
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 104
atggatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 60
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 120
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 180
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 240
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 300
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 360
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 420
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 480
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 540
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 600
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 660
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 720
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 780
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 840
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 900
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 960
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 1020
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 1080
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 1140
cgacatgact caggatatga agttggagga ggagatgcag aattccgaca tgactcagga 1200
tatgaagttg gaggaggaga tgcagaattc cgacatgact caggatatga agttggagga 1260
ggagatgcag aattccgaca tgactcagga tatgaagttg gaggaggaga tgcagaattc 1320
cgacatgact caggatatga agttggagga ggagacatca tcaagctgct gaacgagcaa 1380
gtgaataagg agatgaacag ctccaatctg tacatgtcta tgtctagctg gtgctataca 1440
cacagtctgg acggagcagg cctgttcctg tttgatcacg ccgccgagga gtatgagcac 1500
gccaagaagc tgatcatctt tctgaatgag aacaatgtgc ctgtgcagct gacctctatc 1560
agcgccccag agcacaagtt cgagggcctg acacagatct ttcagaaggc ctacgagcac 1620
gagcagcaca tctccgagtc tatcaacaat atcgtggacc acgccatcaa gtccaaggat 1680
cacgccacct tcaactttct gcagtggtac gtggccgagc agcacgagga ggaggtgctg 1740
tttaaggaca tcctggataa gatcgagctg atcggcaatg agaaccacgg gctgtatctg 1800
gctgaccagt atgtcaaggg catcgcaaaa tcacgcaaat cataa 1845
<210> 105
<211> 606
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 105
atggatgcag aattccgaca tggaggagga acacaatgca atgtcaaccc ggtccagatt 60
cccaaggact ggatcacgat gcaccgctcc tgccgcaact cgatgcgtca gcagatacag 120
atggaggtcg gcgcctcgct gcagtacctg gccatgggcg ctcacttctc taaagatgtg 180
gtaaaccgac ctggcttcgc tcagctgttc ttcgacgccg cttcggagga acgtgaacac 240
gcgatgaagc ttattgaata cctcctcatg agaggagaac tcaccaacga tgtcagctca 300
ctgcttcaag tcaggccccc aactcgttct tcctggaagg gtggtgtaga ggccctggaa 360
cacgcgctga gcatggagag tgacgtcacc aagagcatca ggaacgtcat caaggcttgc 420
gaggatgaca gcgaattcaa tgactaccat cttgtcgact accttaccgg cgatttcttg 480
gaagagcaat acaagggaca acgcgacctc gccggcaagg cctccaccct caagaaactc 540
atggaccgcc atgaggccct cggagaattc atcttcgaca agaaactcct tggcatcgat 600
gtctaa 606
<210> 106
<211> 633
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 106
atggatgcag aattccgaca tggaggagga ggaataactt ctaatagcct tgctcttccc 60
cggtgtaacg cggtatacgg cgagtacggt agccatggta acgtggcaac tgagctccaa 120
gcatacgcca agctccacct agagaggtct tacgactacc tcctctcggc tgcatacttc 180
aacaactacc agacaaacag ggccggattc agcaaactgt tcaagaagtt atccgatgaa 240
gcctggagca agaccattga tattatcaag catgttacta agagaggtga caaaatgaac 300
ttcgaccagc acagcacgat gaagactgaa cgcaagaact acaccgctga gaaccacgag 360
ctggaggctc tcgccaaggc tctggacaca cagaaggagc tcgctgaacg cgccttttac 420
atccacaggg aggccaccag gaacagccag catttacatg accctgagat cgctcaatac 480
ctcgaagaag agttcattga agaccacgct gagaagatca ggaccctcgc tggtcacacc 540
tctgacctca agaagttcat cacggccaac aacggacacg acttgtctct ggccttgtac 600
gtcttcgacg aatacctcca gaagaccgtt taa 633
<210> 107
<211> 660
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 107
atggatgcag aattccgaca tggaggagga gatgcagaat tccgacatgg aggaggagat 60
gcagaattcc gacatggagg aggaacacaa tgcaatgtca acccggtcca gattcccaag 120
gactggatca cgatgcaccg ctcctgccgc aactcgatgc gtcagcagat acagatggag 180
gtcggcgcct cgctgcagta cctggccatg ggcgctcact tctctaaaga tgtggtaaac 240
cgacctggct tcgctcagct gttcttcgac gccgcttcgg aggaacgtga acacgcgatg 300
aagcttattg aatacctcct catgagagga gaactcacca acgatgtcag ctcactgctt 360
caagtcaggc ccccaactcg ttcttcctgg aagggtggtg tagaggccct ggaacacgcg 420
ctgagcatgg agagtgacgt caccaagagc atcaggaacg tcatcaaggc ttgcgaggat 480
gacagcgaat tcaatgacta ccatcttgtc gactacctta ccggcgattt cttggaagag 540
caatacaagg gacaacgcga cctcgccggc aaggcctcca ccctcaagaa actcatggac 600
cgccatgagg ccctcggaga attcatcttc gacaagaaac tccttggcat cgatgtctaa 660
<210> 108
<211> 687
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 108
atggatgcag aattccgaca tggaggagga gatgcagaat tccgacatgg aggaggagat 60
gcagaattcc gacatggagg aggaggaata acttctaata gccttgctct tccccggtgt 120
aacgcggtat acggcgagta cggtagccat ggtaacgtgg caactgagct ccaagcatac 180
gccaagctcc acctagagag gtcttacgac tacctcctct cggctgcata cttcaacaac 240
taccagacaa acagggccgg attcagcaaa ctgttcaaga agttatccga tgaagcctgg 300
agcaagacca ttgatattat caagcatgtt actaagagag gtgacaaaat gaacttcgac 360
cagcacagca cgatgaagac tgaacgcaag aactacaccg ctgagaacca cgagctggag 420
gctctcgcca aggctctgga cacacagaag gagctcgctg aacgcgcctt ttacatccac 480
agggaggcca ccaggaacag ccagcattta catgaccctg agatcgctca atacctcgaa 540
gaagagttca ttgaagacca cgctgagaag atcaggaccc tcgctggtca cacctctgac 600
ctcaagaagt tcatcacggc caacaacgga cacgacttgt ctctggcctt gtacgtcttc 660
gacgaatacc tccagaagac cgtttaa 687
<210> 109
<211> 849
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 109
atggatgcag aattccgaca tggaggagga gatgcagaat tccgacatgg aggaggagat 60
gcagaattcc gacatggagg aggagatgca gaattccgac atggaggagg agatgcagaa 120
ttccgacatg gaggaggaga tgcagaattc cgacatggag gaggagatgc agaattccga 180
catggaggag gagatgcaga attccgacat ggaggaggag atgcagaatt ccgacatgga 240
ggaggagatg cagaattccg acatggagga ggaacacaat gcaatgtcaa cccggtccag 300
attcccaagg actggatcac gatgcaccgc tcctgccgca actcgatgcg tcagcagata 360
cagatggagg tcggcgcctc gctgcagtac ctggccatgg gcgctcactt ctctaaagat 420
gtggtaaacc gacctggctt cgctcagctg ttcttcgacg ccgcttcgga ggaacgtgaa 480
cacgcgatga agcttattga atacctcctc atgagaggag aactcaccaa cgatgtcagc 540
tcactgcttc aagtcaggcc cccaactcgt tcttcctgga agggtggtgt agaggccctg 600
gaacacgcgc tgagcatgga gagtgacgtc accaagagca tcaggaacgt catcaaggct 660
tgcgaggatg acagcgaatt caatgactac catcttgtcg actaccttac cggcgatttc 720
ttggaagagc aatacaaggg acaacgcgac ctcgccggca aggcctccac cctcaagaaa 780
ctcatggacc gccatgaggc cctcggagaa ttcatcttcg acaagaaact ccttggcatc 840
gatgtctaa 849
<210> 110
<211> 876
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 110
atggatgcag aattccgaca tggaggagga gatgcagaat tccgacatgg aggaggagat 60
gcagaattcc gacatggagg aggagatgca gaattccgac atggaggagg agatgcagaa 120
ttccgacatg gaggaggaga tgcagaattc cgacatggag gaggagatgc agaattccga 180
catggaggag gagatgcaga attccgacat ggaggaggag atgcagaatt ccgacatgga 240
ggaggagatg cagaattccg acatggagga ggaggaataa cttctaatag ccttgctctt 300
ccccggtgta acgcggtata cggcgagtac ggtagccatg gtaacgtggc aactgagctc 360
caagcatacg ccaagctcca cctagagagg tcttacgact acctcctctc ggctgcatac 420
ttcaacaact accagacaaa cagggccgga ttcagcaaac tgttcaagaa gttatccgat 480
gaagcctgga gcaagaccat tgatattatc aagcatgtta ctaagagagg tgacaaaatg 540
aacttcgacc agcacagcac gatgaagact gaacgcaaga actacaccgc tgagaaccac 600
gagctggagg ctctcgccaa ggctctggac acacagaagg agctcgctga acgcgccttt 660
tacatccaca gggaggccac caggaacagc cagcatttac atgaccctga gatcgctcaa 720
tacctcgaag aagagttcat tgaagaccac gctgagaaga tcaggaccct cgctggtcac 780
acctctgacc tcaagaagtt catcacggcc aacaacggac acgacttgtc tctggccttg 840
tacgtcttcg acgaatacct ccagaagacc gtttaa 876
<210> 111
<211> 1119
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 111
atggatgcag aattccgaca tggaggagga gatgcagaat tccgacatgg aggaggagat 60
gcagaattcc gacatggagg aggagatgca gaattccgac atggaggagg agatgcagaa 120
ttccgacatg gaggaggaga tgcagaattc cgacatggag gaggagatgc agaattccga 180
catggaggag gagatgcaga attccgacat ggaggaggag atgcagaatt ccgacatgga 240
ggaggagatg cagaattccg acatggagga ggagatgcag aattccgaca tggaggagga 300
gatgcagaat tccgacatgg aggaggagat gcagaattcc gacatggagg aggagatgca 360
gaattccgac atggaggagg agatgcagaa ttccgacatg gaggaggaga tgcagaattc 420
cgacatggag gaggagatgc agaattccga catggaggag gagatgcaga attccgacat 480
ggaggaggag atgcagaatt ccgacatgga ggaggagatg cagaattccg acatggagga 540
ggaacacaat gcaatgtcaa cccggtccag attcccaagg actggatcac gatgcaccgc 600
tcctgccgca actcgatgcg tcagcagata cagatggagg tcggcgcctc gctgcagtac 660
ctggccatgg gcgctcactt ctctaaagat gtggtaaacc gacctggctt cgctcagctg 720
ttcttcgacg ccgcttcgga ggaacgtgaa cacgcgatga agcttattga atacctcctc 780
atgagaggag aactcaccaa cgatgtcagc tcactgcttc aagtcaggcc cccaactcgt 840
tcttcctgga agggtggtgt agaggccctg gaacacgcgc tgagcatgga gagtgacgtc 900
accaagagca tcaggaacgt catcaaggct tgcgaggatg acagcgaatt caatgactac 960
catcttgtcg actaccttac cggcgatttc ttggaagagc aatacaaggg acaacgcgac 1020
ctcgccggca aggcctccac cctcaagaaa ctcatggacc gccatgaggc cctcggagaa 1080
ttcatcttcg acaagaaact ccttggcatc gatgtctaa 1119
<210> 112
<211> 1146
<212> DNA
<213> 合成序列(Synthetic Sequence)
<400> 112
atggatgcag aattccgaca tggaggagga gatgcagaat tccgacatgg aggaggagat 60
gcagaattcc gacatggagg aggagatgca gaattccgac atggaggagg agatgcagaa 120
ttccgacatg gaggaggaga tgcagaattc cgacatggag gaggagatgc agaattccga 180
catggaggag gagatgcaga attccgacat ggaggaggag atgcagaatt ccgacatgga 240
ggaggagatg cagaattccg acatggagga ggagatgcag aattccgaca tggaggagga 300
gatgcagaat tccgacatgg aggaggagat gcagaattcc gacatggagg aggagatgca 360
gaattccgac atggaggagg agatgcagaa ttccgacatg gaggaggaga tgcagaattc 420
cgacatggag gaggagatgc agaattccga catggaggag gagatgcaga attccgacat 480
ggaggaggag atgcagaatt ccgacatgga ggaggagatg cagaattccg acatggagga 540
ggaggaataa cttctaatag ccttgctctt ccccggtgta acgcggtata cggcgagtac 600
ggtagccatg gtaacgtggc aactgagctc caagcatacg ccaagctcca cctagagagg 660
tcttacgact acctcctctc ggctgcatac ttcaacaact accagacaaa cagggccgga 720
ttcagcaaac tgttcaagaa gttatccgat gaagcctgga gcaagaccat tgatattatc 780
aagcatgtta ctaagagagg tgacaaaatg aacttcgacc agcacagcac gatgaagact 840
gaacgcaaga actacaccgc tgagaaccac gagctggagg ctctcgccaa ggctctggac 900
acacagaagg agctcgctga acgcgccttt tacatccaca gggaggccac caggaacagc 960
cagcatttac atgaccctga gatcgctcaa tacctcgaag aagagttcat tgaagaccac 1020
gctgagaaga tcaggaccct cgctggtcac acctctgacc tcaagaagtt catcacggcc 1080
aacaacggac acgacttgtc tctggccttg tacgtcttcg acgaatacct ccagaagacc 1140
gtttaa 1146
<210> 113
<211> 173
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 113
Met Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ile Ile Lys Leu Leu
1 5 10 15
Asn Glu Gln Val Asn Lys Glu Met Asn Ser Ser Asn Leu Tyr Met Ser
20 25 30
Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe
35 40 45
Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile
50 55 60
Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser
65 70 75 80
Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala
85 90 95
Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp
100 105 110
His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp
115 120 125
Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu
130 135 140
Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala
145 150 155 160
Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser
165 170
<210> 114
<211> 176
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 114
Met Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ile Ile
1 5 10 15
Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Asn Ser Ser Asn Leu
20 25 30
Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala
35 40 45
Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys
50 55 60
Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr
65 70 75 80
Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe
85 90 95
Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn
100 105 110
Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe
115 120 125
Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys
130 135 140
Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu
145 150 155 160
Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser
165 170 175
<210> 115
<211> 179
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 115
Met Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly
1 5 10 15
Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Asn Ser
20 25 30
Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu
35 40 45
Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu
50 55 60
His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val
65 70 75 80
Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr
85 90 95
Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser
100 105 110
Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr
115 120 125
Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val
130 135 140
Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn
145 150 155 160
His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser
165 170 175
Arg Lys Ser
<210> 116
<211> 182
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 116
Met Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His
1 5 10 15
Gly Gly Gly Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu
20 25 30
Met Asn Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr
35 40 45
His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu
50 55 60
Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn
65 70 75 80
Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu
85 90 95
Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile
100 105 110
Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp
115 120 125
His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu
130 135 140
Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly
145 150 155 160
Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile
165 170 175
Ala Lys Ser Arg Lys Ser
180
<210> 117
<211> 188
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 117
Met Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
1 5 10 15
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ile Ile Lys Leu Leu Asn
20 25 30
Glu Gln Val Asn Lys Glu Met Asn Ser Ser Asn Leu Tyr Met Ser Met
35 40 45
Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu
50 55 60
Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile
65 70 75 80
Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala
85 90 95
Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr
100 105 110
Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His
115 120 125
Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr
130 135 140
Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp
145 150 155 160
Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp
165 170 175
Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser
180 185
<210> 118
<211> 194
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 118
Met Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly
1 5 10 15
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp
20 25 30
Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Asn Ser Ser
35 40 45
Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp
50 55 60
Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His
65 70 75 80
Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln
85 90 95
Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln
100 105 110
Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile
115 120 125
Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe
130 135 140
Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu
145 150 155 160
Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His
165 170 175
Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg
180 185 190
Lys Ser
<210> 119
<211> 191
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 119
Met Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His
1 5 10 15
Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ile Ile Lys
20 25 30
Leu Leu Asn Glu Gln Val Asn Lys Glu Met Asn Ser Ser Asn Leu Tyr
35 40 45
Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly
50 55 60
Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys
65 70 75 80
Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser
85 90 95
Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln
100 105 110
Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile
115 120 125
Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu
130 135 140
Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp
145 150 155 160
Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr
165 170 175
Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser
180 185 190
<210> 120
<211> 200
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 120
Met Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
1 5 10 15
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
20 25 30
Ser Gly Gly Gly Gly Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn
35 40 45
Lys Glu Met Asn Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys
50 55 60
Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala
65 70 75 80
Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu
85 90 95
Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys
100 105 110
Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln
115 120 125
His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser
130 135 140
Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln
145 150 155 160
His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu
165 170 175
Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys
180 185 190
Gly Ile Ala Lys Ser Arg Lys Ser
195 200
<210> 121
<211> 209
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 121
Met Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly
1 5 10 15
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp
20 25 30
Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ile
35 40 45
Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Asn Ser Ser Asn
50 55 60
Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly
65 70 75 80
Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala
85 90 95
Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu
100 105 110
Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile
115 120 125
Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn
130 135 140
Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn
145 150 155 160
Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe
165 170 175
Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly
180 185 190
Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys
195 200 205
Ser
<210> 122
<211> 200
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 122
Met Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His
1 5 10 15
Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe
20 25 30
Arg His Gly Gly Gly Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn
35 40 45
Lys Glu Met Asn Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys
50 55 60
Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala
65 70 75 80
Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu
85 90 95
Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys
100 105 110
Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln
115 120 125
His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser
130 135 140
Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln
145 150 155 160
His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu
165 170 175
Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys
180 185 190
Gly Ile Ala Lys Ser Arg Lys Ser
195 200
<210> 123
<211> 212
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 123
Met Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
1 5 10 15
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
20 25 30
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
35 40 45
Gly Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Asn
50 55 60
Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser
65 70 75 80
Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr
85 90 95
Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro
100 105 110
Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu
115 120 125
Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu
130 135 140
Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala
145 150 155 160
Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu
165 170 175
Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu
180 185 190
Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys
195 200 205
Ser Arg Lys Ser
210
<210> 124
<211> 224
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 124
Met Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly
1 5 10 15
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp
20 25 30
Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ile Ile
50 55 60
Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Asn Ser Ser Asn Leu
65 70 75 80
Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala
85 90 95
Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys
100 105 110
Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr
115 120 125
Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe
130 135 140
Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn
145 150 155 160
Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe
165 170 175
Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys
180 185 190
Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu
195 200 205
Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser
210 215 220
<210> 125
<211> 209
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 125
Met Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His
1 5 10 15
Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe
20 25 30
Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ile
35 40 45
Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Asn Ser Ser Asn
50 55 60
Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly
65 70 75 80
Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala
85 90 95
Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu
100 105 110
Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile
115 120 125
Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn
130 135 140
Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn
145 150 155 160
Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe
165 170 175
Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly
180 185 190
Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys
195 200 205
Ser
<210> 126
<211> 224
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 126
Met Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
1 5 10 15
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
20 25 30
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
35 40 45
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ile Ile
50 55 60
Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Asn Ser Ser Asn Leu
65 70 75 80
Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala
85 90 95
Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys
100 105 110
Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr
115 120 125
Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe
130 135 140
Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn
145 150 155 160
Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe
165 170 175
Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys
180 185 190
Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu
195 200 205
Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser
210 215 220
<210> 127
<211> 239
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 127
Met Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly
1 5 10 15
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp
20 25 30
Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu
50 55 60
Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ile Ile Lys
65 70 75 80
Leu Leu Asn Glu Gln Val Asn Lys Glu Met Asn Ser Ser Asn Leu Tyr
85 90 95
Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly
100 105 110
Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys
115 120 125
Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser
130 135 140
Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln
145 150 155 160
Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile
165 170 175
Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu
180 185 190
Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp
195 200 205
Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr
210 215 220
Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser
225 230 235
<210> 128
<211> 218
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 128
Met Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His
1 5 10 15
Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe
20 25 30
Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Gly Gly Gly Asp Ile Ile Lys Leu Leu Asn Glu Gln
50 55 60
Val Asn Lys Glu Met Asn Ser Ser Asn Leu Tyr Met Ser Met Ser Ser
65 70 75 80
Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp
85 90 95
His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu
100 105 110
Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu
115 120 125
His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His
130 135 140
Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile
145 150 155 160
Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala
165 170 175
Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile
180 185 190
Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr
195 200 205
Val Lys Gly Ile Ala Lys Ser Arg Lys Ser
210 215
<210> 129
<211> 236
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 129
Met Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
1 5 10 15
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
20 25 30
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
35 40 45
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
50 55 60
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ile Ile Lys Leu Leu Asn
65 70 75 80
Glu Gln Val Asn Lys Glu Met Asn Ser Ser Asn Leu Tyr Met Ser Met
85 90 95
Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu
100 105 110
Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile
115 120 125
Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala
130 135 140
Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr
145 150 155 160
Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His
165 170 175
Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr
180 185 190
Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp
195 200 205
Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp
210 215 220
Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser
225 230 235
<210> 130
<211> 254
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 130
Met Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly
1 5 10 15
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp
20 25 30
Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu
50 55 60
Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe
65 70 75 80
Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ile Ile Lys Leu
85 90 95
Leu Asn Glu Gln Val Asn Lys Glu Met Asn Ser Ser Asn Leu Tyr Met
100 105 110
Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu
115 120 125
Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu
130 135 140
Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile
145 150 155 160
Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys
165 170 175
Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val
180 185 190
Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln
195 200 205
Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile
210 215 220
Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu
225 230 235 240
Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser
245 250
<210> 131
<211> 227
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 131
Met Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His
1 5 10 15
Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe
20 25 30
Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly
50 55 60
Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Asn Ser
65 70 75 80
Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu
85 90 95
Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu
100 105 110
His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val
115 120 125
Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr
130 135 140
Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser
145 150 155 160
Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr
165 170 175
Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val
180 185 190
Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn
195 200 205
His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser
210 215 220
Arg Lys Ser
225
<210> 132
<211> 248
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 132
Met Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
1 5 10 15
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
20 25 30
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
35 40 45
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
50 55 60
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
65 70 75 80
Ser Gly Gly Gly Gly Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn
85 90 95
Lys Glu Met Asn Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys
100 105 110
Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala
115 120 125
Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu
130 135 140
Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys
145 150 155 160
Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln
165 170 175
His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser
180 185 190
Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln
195 200 205
His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu
210 215 220
Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys
225 230 235 240
Gly Ile Ala Lys Ser Arg Lys Ser
245
<210> 133
<211> 269
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 133
Met Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly
1 5 10 15
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp
20 25 30
Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu
50 55 60
Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe
65 70 75 80
Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg
85 90 95
His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ile Ile Lys Leu Leu
100 105 110
Asn Glu Gln Val Asn Lys Glu Met Asn Ser Ser Asn Leu Tyr Met Ser
115 120 125
Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe
130 135 140
Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile
145 150 155 160
Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser
165 170 175
Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala
180 185 190
Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp
195 200 205
His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp
210 215 220
Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu
225 230 235 240
Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala
245 250 255
Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser
260 265
<210> 134
<211> 236
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 134
Met Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His
1 5 10 15
Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe
20 25 30
Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly
50 55 60
Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ile Ile Lys Leu Leu Asn
65 70 75 80
Glu Gln Val Asn Lys Glu Met Asn Ser Ser Asn Leu Tyr Met Ser Met
85 90 95
Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu
100 105 110
Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile
115 120 125
Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala
130 135 140
Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr
145 150 155 160
Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His
165 170 175
Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr
180 185 190
Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp
195 200 205
Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp
210 215 220
Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser
225 230 235
<210> 135
<211> 260
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 135
Met Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
1 5 10 15
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
20 25 30
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
35 40 45
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
50 55 60
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
65 70 75 80
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
85 90 95
Gly Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Asn
100 105 110
Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser
115 120 125
Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr
130 135 140
Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro
145 150 155 160
Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu
165 170 175
Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu
180 185 190
Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala
195 200 205
Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu
210 215 220
Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu
225 230 235 240
Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys
245 250 255
Ser Arg Lys Ser
260
<210> 136
<211> 284
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 136
Met Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly
1 5 10 15
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp
20 25 30
Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu
50 55 60
Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe
65 70 75 80
Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg
85 90 95
His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His
100 105 110
Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ile Ile Lys Leu Leu Asn
115 120 125
Glu Gln Val Asn Lys Glu Met Asn Ser Ser Asn Leu Tyr Met Ser Met
130 135 140
Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu
145 150 155 160
Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile
165 170 175
Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala
180 185 190
Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr
195 200 205
Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His
210 215 220
Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr
225 230 235 240
Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp
245 250 255
Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp
260 265 270
Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser
275 280
<210> 137
<211> 245
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 137
Met Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His
1 5 10 15
Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe
20 25 30
Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly
50 55 60
Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly
65 70 75 80
Gly Gly Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met
85 90 95
Asn Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His
100 105 110
Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu
115 120 125
Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val
130 135 140
Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly
145 150 155 160
Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser
165 170 175
Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His
180 185 190
Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu
195 200 205
Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn
210 215 220
Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala
225 230 235 240
Lys Ser Arg Lys Ser
245
<210> 138
<211> 272
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 138
Met Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
1 5 10 15
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
20 25 30
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
35 40 45
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
50 55 60
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
65 70 75 80
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
85 90 95
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ile Ile
100 105 110
Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Asn Ser Ser Asn Leu
115 120 125
Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala
130 135 140
Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys
145 150 155 160
Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr
165 170 175
Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe
180 185 190
Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn
195 200 205
Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe
210 215 220
Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys
225 230 235 240
Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu
245 250 255
Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser
260 265 270
<210> 139
<211> 299
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 139
Met Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly
1 5 10 15
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp
20 25 30
Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu
50 55 60
Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe
65 70 75 80
Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg
85 90 95
His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His
100 105 110
Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp
115 120 125
Ser Gly Tyr Glu Val Gly Gly Gly Asp Ile Ile Lys Leu Leu Asn Glu
130 135 140
Gln Val Asn Lys Glu Met Asn Ser Ser Asn Leu Tyr Met Ser Met Ser
145 150 155 160
Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe
165 170 175
Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe
180 185 190
Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro
195 200 205
Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu
210 215 220
His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala
225 230 235 240
Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val
245 250 255
Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys
260 265 270
Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln
275 280 285
Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser
290 295
<210> 140
<211> 254
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 140
Met Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His
1 5 10 15
Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe
20 25 30
Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly
50 55 60
Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly
65 70 75 80
Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ile Ile Lys Leu
85 90 95
Leu Asn Glu Gln Val Asn Lys Glu Met Asn Ser Ser Asn Leu Tyr Met
100 105 110
Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu
115 120 125
Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu
130 135 140
Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile
145 150 155 160
Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys
165 170 175
Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val
180 185 190
Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln
195 200 205
Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile
210 215 220
Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu
225 230 235 240
Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser
245 250
<210> 141
<211> 284
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 141
Met Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
1 5 10 15
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
20 25 30
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
35 40 45
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
50 55 60
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
65 70 75 80
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
85 90 95
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
100 105 110
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ile Ile Lys Leu Leu Asn
115 120 125
Glu Gln Val Asn Lys Glu Met Asn Ser Ser Asn Leu Tyr Met Ser Met
130 135 140
Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu
145 150 155 160
Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile
165 170 175
Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala
180 185 190
Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr
195 200 205
Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His
210 215 220
Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr
225 230 235 240
Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp
245 250 255
Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp
260 265 270
Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser
275 280
<210> 142
<211> 314
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 142
Met Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly
1 5 10 15
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp
20 25 30
Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu
50 55 60
Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe
65 70 75 80
Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg
85 90 95
His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His
100 105 110
Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp
115 120 125
Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser
130 135 140
Gly Tyr Glu Val Gly Gly Gly Asp Ile Ile Lys Leu Leu Asn Glu Gln
145 150 155 160
Val Asn Lys Glu Met Asn Ser Ser Asn Leu Tyr Met Ser Met Ser Ser
165 170 175
Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp
180 185 190
His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu
195 200 205
Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu
210 215 220
His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His
225 230 235 240
Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile
245 250 255
Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala
260 265 270
Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile
275 280 285
Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr
290 295 300
Val Lys Gly Ile Ala Lys Ser Arg Lys Ser
305 310
<210> 143
<211> 263
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 143
Met Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His
1 5 10 15
Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe
20 25 30
Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly
50 55 60
Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly
65 70 75 80
Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg
85 90 95
His Gly Gly Gly Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys
100 105 110
Glu Met Asn Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr
115 120 125
Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala
130 135 140
Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn
145 150 155 160
Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe
165 170 175
Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His
180 185 190
Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys
195 200 205
Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His
210 215 220
Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile
225 230 235 240
Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly
245 250 255
Ile Ala Lys Ser Arg Lys Ser
260
<210> 144
<211> 296
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 144
Met Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
1 5 10 15
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
20 25 30
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
35 40 45
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
50 55 60
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
65 70 75 80
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
85 90 95
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
100 105 110
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
115 120 125
Ser Gly Gly Gly Gly Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn
130 135 140
Lys Glu Met Asn Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys
145 150 155 160
Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala
165 170 175
Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu
180 185 190
Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys
195 200 205
Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln
210 215 220
His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser
225 230 235 240
Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln
245 250 255
His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu
260 265 270
Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys
275 280 285
Gly Ile Ala Lys Ser Arg Lys Ser
290 295
<210> 145
<211> 329
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 145
Met Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly
1 5 10 15
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp
20 25 30
Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu
50 55 60
Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe
65 70 75 80
Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg
85 90 95
His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His
100 105 110
Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp
115 120 125
Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser
130 135 140
Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly
145 150 155 160
Tyr Glu Val Gly Gly Gly Asp Ile Ile Lys Leu Leu Asn Glu Gln Val
165 170 175
Asn Lys Glu Met Asn Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp
180 185 190
Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His
195 200 205
Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn
210 215 220
Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His
225 230 235 240
Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu
245 250 255
Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys
260 265 270
Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu
275 280 285
Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu
290 295 300
Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val
305 310 315 320
Lys Gly Ile Ala Lys Ser Arg Lys Ser
325
<210> 146
<211> 272
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 146
Met Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His
1 5 10 15
Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe
20 25 30
Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly
50 55 60
Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly
65 70 75 80
Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg
85 90 95
His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ile Ile
100 105 110
Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Asn Ser Ser Asn Leu
115 120 125
Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala
130 135 140
Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys
145 150 155 160
Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr
165 170 175
Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe
180 185 190
Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn
195 200 205
Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe
210 215 220
Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys
225 230 235 240
Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu
245 250 255
Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser
260 265 270
<210> 147
<211> 308
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 147
Met Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
1 5 10 15
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
20 25 30
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
35 40 45
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
50 55 60
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
65 70 75 80
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
85 90 95
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
100 105 110
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
115 120 125
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
130 135 140
Gly Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Asn
145 150 155 160
Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser
165 170 175
Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr
180 185 190
Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro
195 200 205
Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu
210 215 220
Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu
225 230 235 240
Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala
245 250 255
Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu
260 265 270
Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu
275 280 285
Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys
290 295 300
Ser Arg Lys Ser
305
<210> 148
<211> 344
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 148
Met Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly
1 5 10 15
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp
20 25 30
Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu
50 55 60
Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe
65 70 75 80
Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg
85 90 95
His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His
100 105 110
Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp
115 120 125
Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser
130 135 140
Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly
145 150 155 160
Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr
165 170 175
Glu Val Gly Gly Gly Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn
180 185 190
Lys Glu Met Asn Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys
195 200 205
Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala
210 215 220
Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu
225 230 235 240
Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys
245 250 255
Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln
260 265 270
His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser
275 280 285
Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln
290 295 300
His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu
305 310 315 320
Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys
325 330 335
Gly Ile Ala Lys Ser Arg Lys Ser
340
<210> 149
<211> 281
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 149
Met Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His
1 5 10 15
Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe
20 25 30
Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly
50 55 60
Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly
65 70 75 80
Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg
85 90 95
His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu
100 105 110
Phe Arg His Gly Gly Gly Asp Ile Ile Lys Leu Leu Asn Glu Gln Val
115 120 125
Asn Lys Glu Met Asn Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp
130 135 140
Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His
145 150 155 160
Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn
165 170 175
Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His
180 185 190
Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu
195 200 205
Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys
210 215 220
Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu
225 230 235 240
Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu
245 250 255
Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val
260 265 270
Lys Gly Ile Ala Lys Ser Arg Lys Ser
275 280
<210> 150
<211> 320
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 150
Met Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
1 5 10 15
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
20 25 30
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
35 40 45
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
50 55 60
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
65 70 75 80
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
85 90 95
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
100 105 110
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
115 120 125
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
130 135 140
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ile Ile
145 150 155 160
Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Asn Ser Ser Asn Leu
165 170 175
Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala
180 185 190
Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys
195 200 205
Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr
210 215 220
Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe
225 230 235 240
Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn
245 250 255
Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe
260 265 270
Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys
275 280 285
Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu
290 295 300
Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser
305 310 315 320
<210> 151
<211> 359
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 151
Met Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly
1 5 10 15
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp
20 25 30
Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu
50 55 60
Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe
65 70 75 80
Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg
85 90 95
His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His
100 105 110
Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp
115 120 125
Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser
130 135 140
Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly
145 150 155 160
Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr
165 170 175
Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu
180 185 190
Val Gly Gly Gly Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys
195 200 205
Glu Met Asn Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr
210 215 220
Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala
225 230 235 240
Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn
245 250 255
Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe
260 265 270
Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His
275 280 285
Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys
290 295 300
Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His
305 310 315 320
Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile
325 330 335
Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly
340 345 350
Ile Ala Lys Ser Arg Lys Ser
355
<210> 152
<211> 290
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 152
Met Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His
1 5 10 15
Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe
20 25 30
Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly
50 55 60
Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly
65 70 75 80
Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg
85 90 95
His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu
100 105 110
Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp
115 120 125
Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Asn Ser Ser
130 135 140
Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp
145 150 155 160
Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His
165 170 175
Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln
180 185 190
Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln
195 200 205
Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile
210 215 220
Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe
225 230 235 240
Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu
245 250 255
Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His
260 265 270
Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg
275 280 285
Lys Ser
290
<210> 153
<211> 332
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 153
Met Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
1 5 10 15
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
20 25 30
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
35 40 45
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
50 55 60
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
65 70 75 80
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
85 90 95
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
100 105 110
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
115 120 125
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
130 135 140
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
145 150 155 160
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ile Ile Lys Leu Leu Asn
165 170 175
Glu Gln Val Asn Lys Glu Met Asn Ser Ser Asn Leu Tyr Met Ser Met
180 185 190
Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu
195 200 205
Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile
210 215 220
Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala
225 230 235 240
Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr
245 250 255
Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His
260 265 270
Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr
275 280 285
Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp
290 295 300
Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp
305 310 315 320
Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser
325 330
<210> 154
<211> 374
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 154
Met Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly
1 5 10 15
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp
20 25 30
Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu
50 55 60
Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe
65 70 75 80
Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg
85 90 95
His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His
100 105 110
Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp
115 120 125
Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser
130 135 140
Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly
145 150 155 160
Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr
165 170 175
Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu
180 185 190
Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val
195 200 205
Gly Gly Gly Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu
210 215 220
Met Asn Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr
225 230 235 240
His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu
245 250 255
Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn
260 265 270
Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu
275 280 285
Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile
290 295 300
Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp
305 310 315 320
His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu
325 330 335
Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly
340 345 350
Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile
355 360 365
Ala Lys Ser Arg Lys Ser
370
<210> 155
<211> 299
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 155
Met Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His
1 5 10 15
Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe
20 25 30
Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly
50 55 60
Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly
65 70 75 80
Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg
85 90 95
His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu
100 105 110
Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp
115 120 125
Ala Glu Phe Arg His Gly Gly Gly Asp Ile Ile Lys Leu Leu Asn Glu
130 135 140
Gln Val Asn Lys Glu Met Asn Ser Ser Asn Leu Tyr Met Ser Met Ser
145 150 155 160
Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe
165 170 175
Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe
180 185 190
Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro
195 200 205
Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu
210 215 220
His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala
225 230 235 240
Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val
245 250 255
Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys
260 265 270
Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln
275 280 285
Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser
290 295
<210> 156
<211> 344
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 156
Met Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
1 5 10 15
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
20 25 30
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
35 40 45
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
50 55 60
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
65 70 75 80
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
85 90 95
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
100 105 110
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
115 120 125
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
130 135 140
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
145 150 155 160
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
165 170 175
Ser Gly Gly Gly Gly Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn
180 185 190
Lys Glu Met Asn Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys
195 200 205
Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala
210 215 220
Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu
225 230 235 240
Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys
245 250 255
Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln
260 265 270
His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser
275 280 285
Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln
290 295 300
His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu
305 310 315 320
Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys
325 330 335
Gly Ile Ala Lys Ser Arg Lys Ser
340
<210> 157
<211> 389
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 157
Met Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly
1 5 10 15
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp
20 25 30
Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu
50 55 60
Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe
65 70 75 80
Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg
85 90 95
His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His
100 105 110
Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp
115 120 125
Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser
130 135 140
Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly
145 150 155 160
Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr
165 170 175
Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu
180 185 190
Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val
195 200 205
Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly
210 215 220
Gly Gly Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met
225 230 235 240
Asn Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His
245 250 255
Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu
260 265 270
Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val
275 280 285
Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly
290 295 300
Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser
305 310 315 320
Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His
325 330 335
Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu
340 345 350
Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn
355 360 365
Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala
370 375 380
Lys Ser Arg Lys Ser
385
<210> 158
<211> 308
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 158
Met Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His
1 5 10 15
Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe
20 25 30
Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly
50 55 60
Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly
65 70 75 80
Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg
85 90 95
His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu
100 105 110
Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp
115 120 125
Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly
130 135 140
Gly Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Asn
145 150 155 160
Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser
165 170 175
Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr
180 185 190
Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro
195 200 205
Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu
210 215 220
Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu
225 230 235 240
Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala
245 250 255
Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu
260 265 270
Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu
275 280 285
Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys
290 295 300
Ser Arg Lys Ser
305
<210> 159
<211> 356
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 159
Met Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
1 5 10 15
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
20 25 30
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
35 40 45
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
50 55 60
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
65 70 75 80
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
85 90 95
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
100 105 110
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
115 120 125
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
130 135 140
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
145 150 155 160
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
165 170 175
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
180 185 190
Gly Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Asn
195 200 205
Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser
210 215 220
Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr
225 230 235 240
Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro
245 250 255
Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu
260 265 270
Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu
275 280 285
Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala
290 295 300
Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu
305 310 315 320
Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu
325 330 335
Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys
340 345 350
Ser Arg Lys Ser
355
<210> 160
<211> 404
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 160
Met Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly
1 5 10 15
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp
20 25 30
Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu
50 55 60
Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe
65 70 75 80
Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg
85 90 95
His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His
100 105 110
Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp
115 120 125
Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser
130 135 140
Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly
145 150 155 160
Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr
165 170 175
Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu
180 185 190
Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val
195 200 205
Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly
210 215 220
Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly
225 230 235 240
Gly Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Asn
245 250 255
Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser
260 265 270
Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr
275 280 285
Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro
290 295 300
Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu
305 310 315 320
Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu
325 330 335
Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala
340 345 350
Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu
355 360 365
Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu
370 375 380
Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys
385 390 395 400
Ser Arg Lys Ser
<210> 161
<211> 317
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 161
Met Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His
1 5 10 15
Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe
20 25 30
Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly
50 55 60
Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly
65 70 75 80
Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg
85 90 95
His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu
100 105 110
Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp
115 120 125
Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly
130 135 140
Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ile Ile Lys Leu Leu
145 150 155 160
Asn Glu Gln Val Asn Lys Glu Met Asn Ser Ser Asn Leu Tyr Met Ser
165 170 175
Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe
180 185 190
Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile
195 200 205
Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser
210 215 220
Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala
225 230 235 240
Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp
245 250 255
His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp
260 265 270
Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu
275 280 285
Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala
290 295 300
Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser
305 310 315
<210> 162
<211> 368
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 162
Met Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
1 5 10 15
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
20 25 30
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
35 40 45
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
50 55 60
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
65 70 75 80
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
85 90 95
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
100 105 110
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
115 120 125
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
130 135 140
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
145 150 155 160
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
165 170 175
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
180 185 190
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ile Ile
195 200 205
Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Asn Ser Ser Asn Leu
210 215 220
Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala
225 230 235 240
Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys
245 250 255
Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr
260 265 270
Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe
275 280 285
Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn
290 295 300
Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe
305 310 315 320
Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys
325 330 335
Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu
340 345 350
Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser
355 360 365
<210> 163
<211> 419
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 163
Met Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly
1 5 10 15
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp
20 25 30
Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu
50 55 60
Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe
65 70 75 80
Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg
85 90 95
His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His
100 105 110
Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp
115 120 125
Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser
130 135 140
Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly
145 150 155 160
Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr
165 170 175
Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu
180 185 190
Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val
195 200 205
Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly
210 215 220
Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly
225 230 235 240
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly
245 250 255
Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Asn Ser
260 265 270
Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu
275 280 285
Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu
290 295 300
His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val
305 310 315 320
Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr
325 330 335
Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser
340 345 350
Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr
355 360 365
Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val
370 375 380
Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn
385 390 395 400
His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser
405 410 415
Arg Lys Ser
<210> 164
<211> 326
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 164
Met Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His
1 5 10 15
Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe
20 25 30
Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly
50 55 60
Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly
65 70 75 80
Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg
85 90 95
His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu
100 105 110
Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp
115 120 125
Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly
130 135 140
Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His
145 150 155 160
Gly Gly Gly Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu
165 170 175
Met Asn Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr
180 185 190
His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu
195 200 205
Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn
210 215 220
Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu
225 230 235 240
Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile
245 250 255
Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp
260 265 270
His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu
275 280 285
Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly
290 295 300
Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile
305 310 315 320
Ala Lys Ser Arg Lys Ser
325
<210> 165
<211> 380
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 165
Met Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
1 5 10 15
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
20 25 30
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
35 40 45
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
50 55 60
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
65 70 75 80
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
85 90 95
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
100 105 110
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
115 120 125
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
130 135 140
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
145 150 155 160
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
165 170 175
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
180 185 190
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
195 200 205
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ile Ile Lys Leu Leu Asn
210 215 220
Glu Gln Val Asn Lys Glu Met Asn Ser Ser Asn Leu Tyr Met Ser Met
225 230 235 240
Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu
245 250 255
Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile
260 265 270
Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala
275 280 285
Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr
290 295 300
Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His
305 310 315 320
Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr
325 330 335
Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp
340 345 350
Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp
355 360 365
Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser
370 375 380
<210> 166
<211> 434
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 166
Met Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly
1 5 10 15
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp
20 25 30
Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu
50 55 60
Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe
65 70 75 80
Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg
85 90 95
His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His
100 105 110
Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp
115 120 125
Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser
130 135 140
Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly
145 150 155 160
Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr
165 170 175
Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu
180 185 190
Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val
195 200 205
Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly
210 215 220
Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly
225 230 235 240
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly
245 250 255
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp
260 265 270
Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Asn Ser Ser
275 280 285
Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp
290 295 300
Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His
305 310 315 320
Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln
325 330 335
Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln
340 345 350
Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile
355 360 365
Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe
370 375 380
Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu
385 390 395 400
Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His
405 410 415
Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg
420 425 430
Lys Ser
<210> 167
<211> 335
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 167
Met Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His
1 5 10 15
Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe
20 25 30
Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly
50 55 60
Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly
65 70 75 80
Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg
85 90 95
His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu
100 105 110
Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp
115 120 125
Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly
130 135 140
Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His
145 150 155 160
Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ile Ile Lys
165 170 175
Leu Leu Asn Glu Gln Val Asn Lys Glu Met Asn Ser Ser Asn Leu Tyr
180 185 190
Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly
195 200 205
Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys
210 215 220
Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser
225 230 235 240
Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln
245 250 255
Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile
260 265 270
Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu
275 280 285
Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp
290 295 300
Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr
305 310 315 320
Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser
325 330 335
<210> 168
<211> 392
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 168
Met Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
1 5 10 15
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
20 25 30
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
35 40 45
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
50 55 60
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
65 70 75 80
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
85 90 95
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
100 105 110
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
115 120 125
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
130 135 140
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
145 150 155 160
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
165 170 175
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
180 185 190
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
195 200 205
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
210 215 220
Ser Gly Gly Gly Gly Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn
225 230 235 240
Lys Glu Met Asn Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys
245 250 255
Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala
260 265 270
Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu
275 280 285
Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys
290 295 300
Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln
305 310 315 320
His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser
325 330 335
Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln
340 345 350
His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu
355 360 365
Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys
370 375 380
Gly Ile Ala Lys Ser Arg Lys Ser
385 390
<210> 169
<211> 449
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 169
Met Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly
1 5 10 15
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp
20 25 30
Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu
50 55 60
Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe
65 70 75 80
Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg
85 90 95
His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His
100 105 110
Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp
115 120 125
Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser
130 135 140
Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly
145 150 155 160
Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr
165 170 175
Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu
180 185 190
Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val
195 200 205
Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly
210 215 220
Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly
225 230 235 240
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly
245 250 255
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp
260 265 270
Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ile
275 280 285
Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Asn Ser Ser Asn
290 295 300
Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly
305 310 315 320
Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala
325 330 335
Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu
340 345 350
Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile
355 360 365
Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn
370 375 380
Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn
385 390 395 400
Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe
405 410 415
Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly
420 425 430
Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys
435 440 445
Ser
<210> 170
<211> 344
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 170
Met Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His
1 5 10 15
Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe
20 25 30
Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly
50 55 60
Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly
65 70 75 80
Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg
85 90 95
His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu
100 105 110
Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp
115 120 125
Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly
130 135 140
Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His
145 150 155 160
Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe
165 170 175
Arg His Gly Gly Gly Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn
180 185 190
Lys Glu Met Asn Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys
195 200 205
Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala
210 215 220
Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu
225 230 235 240
Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys
245 250 255
Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln
260 265 270
His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser
275 280 285
Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln
290 295 300
His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu
305 310 315 320
Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys
325 330 335
Gly Ile Ala Lys Ser Arg Lys Ser
340
<210> 171
<211> 404
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 171
Met Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
1 5 10 15
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
20 25 30
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
35 40 45
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
50 55 60
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
65 70 75 80
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
85 90 95
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
100 105 110
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
115 120 125
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
130 135 140
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
145 150 155 160
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
165 170 175
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
180 185 190
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
195 200 205
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
210 215 220
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
225 230 235 240
Gly Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Asn
245 250 255
Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser
260 265 270
Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr
275 280 285
Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro
290 295 300
Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu
305 310 315 320
Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu
325 330 335
Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala
340 345 350
Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu
355 360 365
Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu
370 375 380
Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys
385 390 395 400
Ser Arg Lys Ser
<210> 172
<211> 464
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 172
Met Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly
1 5 10 15
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp
20 25 30
Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu
50 55 60
Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe
65 70 75 80
Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg
85 90 95
His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His
100 105 110
Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp
115 120 125
Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser
130 135 140
Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly
145 150 155 160
Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr
165 170 175
Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu
180 185 190
Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val
195 200 205
Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly
210 215 220
Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly
225 230 235 240
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly
245 250 255
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp
260 265 270
Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala
275 280 285
Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ile Ile
290 295 300
Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Asn Ser Ser Asn Leu
305 310 315 320
Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala
325 330 335
Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys
340 345 350
Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr
355 360 365
Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe
370 375 380
Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn
385 390 395 400
Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe
405 410 415
Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys
420 425 430
Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu
435 440 445
Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser
450 455 460
<210> 173
<211> 353
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 173
Met Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His
1 5 10 15
Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe
20 25 30
Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly
50 55 60
Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly
65 70 75 80
Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg
85 90 95
His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu
100 105 110
Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp
115 120 125
Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly
130 135 140
Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His
145 150 155 160
Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe
165 170 175
Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ile
180 185 190
Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Asn Ser Ser Asn
195 200 205
Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly
210 215 220
Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala
225 230 235 240
Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu
245 250 255
Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile
260 265 270
Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn
275 280 285
Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn
290 295 300
Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe
305 310 315 320
Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly
325 330 335
Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys
340 345 350
Ser
<210> 174
<211> 416
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 174
Met Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
1 5 10 15
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
20 25 30
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
35 40 45
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
50 55 60
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
65 70 75 80
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
85 90 95
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
100 105 110
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
115 120 125
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
130 135 140
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
145 150 155 160
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
165 170 175
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
180 185 190
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
195 200 205
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
210 215 220
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
225 230 235 240
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ile Ile
245 250 255
Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Asn Ser Ser Asn Leu
260 265 270
Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala
275 280 285
Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys
290 295 300
Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr
305 310 315 320
Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe
325 330 335
Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn
340 345 350
Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe
355 360 365
Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys
370 375 380
Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu
385 390 395 400
Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser
405 410 415
<210> 175
<211> 479
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 175
Met Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly
1 5 10 15
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp
20 25 30
Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu
50 55 60
Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe
65 70 75 80
Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg
85 90 95
His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His
100 105 110
Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp
115 120 125
Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser
130 135 140
Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly
145 150 155 160
Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr
165 170 175
Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu
180 185 190
Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val
195 200 205
Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly
210 215 220
Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly
225 230 235 240
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly
245 250 255
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp
260 265 270
Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala
275 280 285
Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu
290 295 300
Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ile Ile Lys
305 310 315 320
Leu Leu Asn Glu Gln Val Asn Lys Glu Met Asn Ser Ser Asn Leu Tyr
325 330 335
Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly
340 345 350
Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys
355 360 365
Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser
370 375 380
Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln
385 390 395 400
Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile
405 410 415
Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu
420 425 430
Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp
435 440 445
Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr
450 455 460
Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser
465 470 475
<210> 176
<211> 362
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 176
Met Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His
1 5 10 15
Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe
20 25 30
Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly
50 55 60
Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly
65 70 75 80
Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg
85 90 95
His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu
100 105 110
Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp
115 120 125
Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly
130 135 140
Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His
145 150 155 160
Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe
165 170 175
Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala
180 185 190
Glu Phe Arg His Gly Gly Gly Asp Ile Ile Lys Leu Leu Asn Glu Gln
195 200 205
Val Asn Lys Glu Met Asn Ser Ser Asn Leu Tyr Met Ser Met Ser Ser
210 215 220
Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp
225 230 235 240
His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu
245 250 255
Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu
260 265 270
His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His
275 280 285
Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile
290 295 300
Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala
305 310 315 320
Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile
325 330 335
Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr
340 345 350
Val Lys Gly Ile Ala Lys Ser Arg Lys Ser
355 360
<210> 177
<211> 428
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 177
Met Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
1 5 10 15
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
20 25 30
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
35 40 45
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
50 55 60
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
65 70 75 80
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
85 90 95
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
100 105 110
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
115 120 125
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
130 135 140
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
145 150 155 160
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
165 170 175
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
180 185 190
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
195 200 205
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
210 215 220
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
225 230 235 240
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
245 250 255
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ile Ile Lys Leu Leu Asn
260 265 270
Glu Gln Val Asn Lys Glu Met Asn Ser Ser Asn Leu Tyr Met Ser Met
275 280 285
Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu
290 295 300
Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile
305 310 315 320
Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala
325 330 335
Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr
340 345 350
Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His
355 360 365
Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr
370 375 380
Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp
385 390 395 400
Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp
405 410 415
Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser
420 425
<210> 178
<211> 494
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 178
Met Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly
1 5 10 15
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp
20 25 30
Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu
50 55 60
Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe
65 70 75 80
Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg
85 90 95
His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His
100 105 110
Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp
115 120 125
Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser
130 135 140
Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly
145 150 155 160
Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr
165 170 175
Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu
180 185 190
Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val
195 200 205
Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly
210 215 220
Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly
225 230 235 240
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly
245 250 255
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp
260 265 270
Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala
275 280 285
Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu
290 295 300
Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe
305 310 315 320
Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ile Ile Lys Leu
325 330 335
Leu Asn Glu Gln Val Asn Lys Glu Met Asn Ser Ser Asn Leu Tyr Met
340 345 350
Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu
355 360 365
Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu
370 375 380
Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile
385 390 395 400
Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys
405 410 415
Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val
420 425 430
Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln
435 440 445
Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile
450 455 460
Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu
465 470 475 480
Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser
485 490
<210> 179
<211> 371
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 179
Met Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His
1 5 10 15
Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe
20 25 30
Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly
50 55 60
Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly
65 70 75 80
Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg
85 90 95
His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu
100 105 110
Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp
115 120 125
Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly
130 135 140
Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His
145 150 155 160
Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe
165 170 175
Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala
180 185 190
Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly
195 200 205
Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Asn Ser
210 215 220
Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu
225 230 235 240
Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu
245 250 255
His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val
260 265 270
Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr
275 280 285
Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser
290 295 300
Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr
305 310 315 320
Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val
325 330 335
Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn
340 345 350
His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser
355 360 365
Arg Lys Ser
370
<210> 180
<211> 440
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 180
Met Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
1 5 10 15
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
20 25 30
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
35 40 45
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
50 55 60
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
65 70 75 80
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
85 90 95
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
100 105 110
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
115 120 125
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
130 135 140
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
145 150 155 160
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
165 170 175
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
180 185 190
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
195 200 205
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
210 215 220
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
225 230 235 240
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
245 250 255
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
260 265 270
Ser Gly Gly Gly Gly Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn
275 280 285
Lys Glu Met Asn Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys
290 295 300
Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala
305 310 315 320
Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu
325 330 335
Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys
340 345 350
Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln
355 360 365
His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser
370 375 380
Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln
385 390 395 400
His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu
405 410 415
Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys
420 425 430
Gly Ile Ala Lys Ser Arg Lys Ser
435 440
<210> 181
<211> 509
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 181
Met Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly
1 5 10 15
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp
20 25 30
Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu
50 55 60
Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe
65 70 75 80
Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg
85 90 95
His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His
100 105 110
Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp
115 120 125
Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser
130 135 140
Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly
145 150 155 160
Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr
165 170 175
Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu
180 185 190
Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val
195 200 205
Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly
210 215 220
Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly
225 230 235 240
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly
245 250 255
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp
260 265 270
Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala
275 280 285
Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu
290 295 300
Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe
305 310 315 320
Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg
325 330 335
His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ile Ile Lys Leu Leu
340 345 350
Asn Glu Gln Val Asn Lys Glu Met Asn Ser Ser Asn Leu Tyr Met Ser
355 360 365
Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe
370 375 380
Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile
385 390 395 400
Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser
405 410 415
Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala
420 425 430
Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp
435 440 445
His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp
450 455 460
Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu
465 470 475 480
Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala
485 490 495
Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser
500 505
<210> 182
<211> 380
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 182
Met Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His
1 5 10 15
Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe
20 25 30
Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly
50 55 60
Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly
65 70 75 80
Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg
85 90 95
His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu
100 105 110
Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp
115 120 125
Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly
130 135 140
Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His
145 150 155 160
Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe
165 170 175
Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala
180 185 190
Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly
195 200 205
Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ile Ile Lys Leu Leu Asn
210 215 220
Glu Gln Val Asn Lys Glu Met Asn Ser Ser Asn Leu Tyr Met Ser Met
225 230 235 240
Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu
245 250 255
Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile
260 265 270
Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala
275 280 285
Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr
290 295 300
Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His
305 310 315 320
Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr
325 330 335
Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp
340 345 350
Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp
355 360 365
Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser
370 375 380
<210> 183
<211> 452
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 183
Met Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
1 5 10 15
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
20 25 30
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
35 40 45
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
50 55 60
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
65 70 75 80
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
85 90 95
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
100 105 110
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
115 120 125
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
130 135 140
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
145 150 155 160
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
165 170 175
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
180 185 190
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
195 200 205
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
210 215 220
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
225 230 235 240
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
245 250 255
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
260 265 270
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
275 280 285
Gly Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Asn
290 295 300
Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser
305 310 315 320
Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr
325 330 335
Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro
340 345 350
Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu
355 360 365
Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu
370 375 380
Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala
385 390 395 400
Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu
405 410 415
Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu
420 425 430
Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys
435 440 445
Ser Arg Lys Ser
450
<210> 184
<211> 524
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 184
Met Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly
1 5 10 15
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp
20 25 30
Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu
50 55 60
Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe
65 70 75 80
Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg
85 90 95
His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His
100 105 110
Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp
115 120 125
Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser
130 135 140
Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly
145 150 155 160
Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr
165 170 175
Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu
180 185 190
Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val
195 200 205
Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly
210 215 220
Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly
225 230 235 240
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly
245 250 255
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp
260 265 270
Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala
275 280 285
Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu
290 295 300
Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe
305 310 315 320
Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg
325 330 335
His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His
340 345 350
Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ile Ile Lys Leu Leu Asn
355 360 365
Glu Gln Val Asn Lys Glu Met Asn Ser Ser Asn Leu Tyr Met Ser Met
370 375 380
Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu
385 390 395 400
Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile
405 410 415
Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala
420 425 430
Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr
435 440 445
Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His
450 455 460
Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr
465 470 475 480
Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp
485 490 495
Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp
500 505 510
Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser
515 520
<210> 185
<211> 389
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 185
Met Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His
1 5 10 15
Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe
20 25 30
Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly
50 55 60
Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly
65 70 75 80
Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg
85 90 95
His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu
100 105 110
Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp
115 120 125
Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly
130 135 140
Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His
145 150 155 160
Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe
165 170 175
Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala
180 185 190
Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly
195 200 205
Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly
210 215 220
Gly Gly Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met
225 230 235 240
Asn Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His
245 250 255
Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu
260 265 270
Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val
275 280 285
Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly
290 295 300
Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser
305 310 315 320
Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His
325 330 335
Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu
340 345 350
Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn
355 360 365
Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala
370 375 380
Lys Ser Arg Lys Ser
385
<210> 186
<211> 464
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 186
Met Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
1 5 10 15
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
20 25 30
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
35 40 45
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
50 55 60
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
65 70 75 80
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
85 90 95
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
100 105 110
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
115 120 125
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
130 135 140
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
145 150 155 160
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
165 170 175
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
180 185 190
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
195 200 205
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
210 215 220
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
225 230 235 240
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
245 250 255
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
260 265 270
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
275 280 285
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ile Ile
290 295 300
Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Asn Ser Ser Asn Leu
305 310 315 320
Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala
325 330 335
Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys
340 345 350
Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr
355 360 365
Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe
370 375 380
Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn
385 390 395 400
Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe
405 410 415
Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys
420 425 430
Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu
435 440 445
Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser
450 455 460
<210> 187
<211> 539
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 187
Met Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly
1 5 10 15
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp
20 25 30
Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu
50 55 60
Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe
65 70 75 80
Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg
85 90 95
His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His
100 105 110
Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp
115 120 125
Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser
130 135 140
Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly
145 150 155 160
Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr
165 170 175
Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu
180 185 190
Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val
195 200 205
Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly
210 215 220
Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly
225 230 235 240
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly
245 250 255
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp
260 265 270
Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala
275 280 285
Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu
290 295 300
Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe
305 310 315 320
Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg
325 330 335
His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His
340 345 350
Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp
355 360 365
Ser Gly Tyr Glu Val Gly Gly Gly Asp Ile Ile Lys Leu Leu Asn Glu
370 375 380
Gln Val Asn Lys Glu Met Asn Ser Ser Asn Leu Tyr Met Ser Met Ser
385 390 395 400
Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe
405 410 415
Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe
420 425 430
Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro
435 440 445
Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu
450 455 460
His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala
465 470 475 480
Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val
485 490 495
Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys
500 505 510
Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln
515 520 525
Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser
530 535
<210> 188
<211> 398
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 188
Met Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His
1 5 10 15
Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe
20 25 30
Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly
50 55 60
Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly
65 70 75 80
Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg
85 90 95
His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu
100 105 110
Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp
115 120 125
Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly
130 135 140
Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His
145 150 155 160
Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe
165 170 175
Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala
180 185 190
Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly
195 200 205
Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly
210 215 220
Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ile Ile Lys Leu
225 230 235 240
Leu Asn Glu Gln Val Asn Lys Glu Met Asn Ser Ser Asn Leu Tyr Met
245 250 255
Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu
260 265 270
Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu
275 280 285
Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile
290 295 300
Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys
305 310 315 320
Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val
325 330 335
Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln
340 345 350
Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile
355 360 365
Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu
370 375 380
Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser
385 390 395
<210> 189
<211> 476
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 189
Met Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
1 5 10 15
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
20 25 30
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
35 40 45
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
50 55 60
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
65 70 75 80
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
85 90 95
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
100 105 110
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
115 120 125
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
130 135 140
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
145 150 155 160
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
165 170 175
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
180 185 190
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
195 200 205
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
210 215 220
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
225 230 235 240
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
245 250 255
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
260 265 270
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
275 280 285
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
290 295 300
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ile Ile Lys Leu Leu Asn
305 310 315 320
Glu Gln Val Asn Lys Glu Met Asn Ser Ser Asn Leu Tyr Met Ser Met
325 330 335
Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu
340 345 350
Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile
355 360 365
Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala
370 375 380
Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr
385 390 395 400
Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His
405 410 415
Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr
420 425 430
Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp
435 440 445
Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp
450 455 460
Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser
465 470 475
<210> 190
<211> 554
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 190
Met Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly
1 5 10 15
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp
20 25 30
Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu
50 55 60
Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe
65 70 75 80
Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg
85 90 95
His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His
100 105 110
Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp
115 120 125
Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser
130 135 140
Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly
145 150 155 160
Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr
165 170 175
Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu
180 185 190
Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val
195 200 205
Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly
210 215 220
Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly
225 230 235 240
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly
245 250 255
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp
260 265 270
Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala
275 280 285
Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu
290 295 300
Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe
305 310 315 320
Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg
325 330 335
His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His
340 345 350
Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp
355 360 365
Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser
370 375 380
Gly Tyr Glu Val Gly Gly Gly Asp Ile Ile Lys Leu Leu Asn Glu Gln
385 390 395 400
Val Asn Lys Glu Met Asn Ser Ser Asn Leu Tyr Met Ser Met Ser Ser
405 410 415
Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp
420 425 430
His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu
435 440 445
Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu
450 455 460
His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His
465 470 475 480
Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile
485 490 495
Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala
500 505 510
Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile
515 520 525
Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr
530 535 540
Val Lys Gly Ile Ala Lys Ser Arg Lys Ser
545 550
<210> 191
<211> 407
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 191
Met Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His
1 5 10 15
Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe
20 25 30
Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly
50 55 60
Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly
65 70 75 80
Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg
85 90 95
His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu
100 105 110
Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp
115 120 125
Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly
130 135 140
Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His
145 150 155 160
Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe
165 170 175
Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala
180 185 190
Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly
195 200 205
Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly
210 215 220
Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg
225 230 235 240
His Gly Gly Gly Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys
245 250 255
Glu Met Asn Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr
260 265 270
Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala
275 280 285
Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn
290 295 300
Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe
305 310 315 320
Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His
325 330 335
Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys
340 345 350
Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His
355 360 365
Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile
370 375 380
Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly
385 390 395 400
Ile Ala Lys Ser Arg Lys Ser
405
<210> 192
<211> 488
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 192
Met Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
1 5 10 15
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
20 25 30
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
35 40 45
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
50 55 60
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
65 70 75 80
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
85 90 95
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
100 105 110
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
115 120 125
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
130 135 140
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
145 150 155 160
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
165 170 175
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
180 185 190
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
195 200 205
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
210 215 220
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
225 230 235 240
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
245 250 255
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
260 265 270
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
275 280 285
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
290 295 300
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
305 310 315 320
Ser Gly Gly Gly Gly Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn
325 330 335
Lys Glu Met Asn Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys
340 345 350
Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala
355 360 365
Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu
370 375 380
Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys
385 390 395 400
Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln
405 410 415
His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser
420 425 430
Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln
435 440 445
His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu
450 455 460
Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys
465 470 475 480
Gly Ile Ala Lys Ser Arg Lys Ser
485
<210> 193
<211> 569
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 193
Met Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly
1 5 10 15
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp
20 25 30
Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu
50 55 60
Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe
65 70 75 80
Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg
85 90 95
His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His
100 105 110
Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp
115 120 125
Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser
130 135 140
Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly
145 150 155 160
Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr
165 170 175
Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu
180 185 190
Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val
195 200 205
Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly
210 215 220
Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly
225 230 235 240
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly
245 250 255
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp
260 265 270
Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala
275 280 285
Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu
290 295 300
Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe
305 310 315 320
Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg
325 330 335
His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His
340 345 350
Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp
355 360 365
Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser
370 375 380
Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly
385 390 395 400
Tyr Glu Val Gly Gly Gly Asp Ile Ile Lys Leu Leu Asn Glu Gln Val
405 410 415
Asn Lys Glu Met Asn Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp
420 425 430
Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His
435 440 445
Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn
450 455 460
Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His
465 470 475 480
Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu
485 490 495
Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys
500 505 510
Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu
515 520 525
Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu
530 535 540
Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val
545 550 555 560
Lys Gly Ile Ala Lys Ser Arg Lys Ser
565
<210> 194
<211> 416
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 194
Met Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His
1 5 10 15
Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe
20 25 30
Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly
50 55 60
Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly
65 70 75 80
Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg
85 90 95
His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu
100 105 110
Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp
115 120 125
Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly
130 135 140
Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His
145 150 155 160
Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe
165 170 175
Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala
180 185 190
Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly
195 200 205
Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly
210 215 220
Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg
225 230 235 240
His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ile Ile
245 250 255
Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Asn Ser Ser Asn Leu
260 265 270
Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala
275 280 285
Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys
290 295 300
Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr
305 310 315 320
Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe
325 330 335
Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn
340 345 350
Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe
355 360 365
Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys
370 375 380
Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu
385 390 395 400
Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser
405 410 415
<210> 195
<211> 500
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 195
Met Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
1 5 10 15
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
20 25 30
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
35 40 45
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
50 55 60
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
65 70 75 80
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
85 90 95
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
100 105 110
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
115 120 125
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
130 135 140
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
145 150 155 160
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
165 170 175
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
180 185 190
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
195 200 205
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
210 215 220
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
225 230 235 240
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
245 250 255
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
260 265 270
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
275 280 285
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
290 295 300
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
305 310 315 320
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
325 330 335
Gly Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Asn
340 345 350
Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser
355 360 365
Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr
370 375 380
Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro
385 390 395 400
Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu
405 410 415
Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu
420 425 430
Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala
435 440 445
Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu
450 455 460
Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu
465 470 475 480
Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys
485 490 495
Ser Arg Lys Ser
500
<210> 196
<211> 584
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 196
Met Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly
1 5 10 15
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp
20 25 30
Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu
50 55 60
Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe
65 70 75 80
Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg
85 90 95
His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His
100 105 110
Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp
115 120 125
Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser
130 135 140
Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly
145 150 155 160
Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr
165 170 175
Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu
180 185 190
Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val
195 200 205
Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly
210 215 220
Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly
225 230 235 240
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly
245 250 255
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp
260 265 270
Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala
275 280 285
Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu
290 295 300
Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe
305 310 315 320
Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg
325 330 335
His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His
340 345 350
Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp
355 360 365
Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser
370 375 380
Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly
385 390 395 400
Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr
405 410 415
Glu Val Gly Gly Gly Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn
420 425 430
Lys Glu Met Asn Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys
435 440 445
Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala
450 455 460
Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu
465 470 475 480
Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys
485 490 495
Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln
500 505 510
His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser
515 520 525
Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln
530 535 540
His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu
545 550 555 560
Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys
565 570 575
Gly Ile Ala Lys Ser Arg Lys Ser
580
<210> 197
<211> 425
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 197
Met Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His
1 5 10 15
Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe
20 25 30
Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly
50 55 60
Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly
65 70 75 80
Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg
85 90 95
His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu
100 105 110
Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp
115 120 125
Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly
130 135 140
Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His
145 150 155 160
Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe
165 170 175
Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala
180 185 190
Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly
195 200 205
Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly
210 215 220
Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg
225 230 235 240
His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu
245 250 255
Phe Arg His Gly Gly Gly Asp Ile Ile Lys Leu Leu Asn Glu Gln Val
260 265 270
Asn Lys Glu Met Asn Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp
275 280 285
Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His
290 295 300
Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn
305 310 315 320
Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His
325 330 335
Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu
340 345 350
Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys
355 360 365
Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu
370 375 380
Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu
385 390 395 400
Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val
405 410 415
Lys Gly Ile Ala Lys Ser Arg Lys Ser
420 425
<210> 198
<211> 512
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 198
Met Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
1 5 10 15
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
20 25 30
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
35 40 45
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
50 55 60
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
65 70 75 80
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
85 90 95
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
100 105 110
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
115 120 125
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
130 135 140
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
145 150 155 160
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
165 170 175
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
180 185 190
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
195 200 205
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
210 215 220
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
225 230 235 240
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
245 250 255
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
260 265 270
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
275 280 285
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
290 295 300
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
305 310 315 320
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
325 330 335
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ile Ile
340 345 350
Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Asn Ser Ser Asn Leu
355 360 365
Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala
370 375 380
Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys
385 390 395 400
Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr
405 410 415
Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe
420 425 430
Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn
435 440 445
Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe
450 455 460
Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys
465 470 475 480
Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu
485 490 495
Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser
500 505 510
<210> 199
<211> 599
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 199
Met Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly
1 5 10 15
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp
20 25 30
Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu
50 55 60
Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe
65 70 75 80
Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg
85 90 95
His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His
100 105 110
Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp
115 120 125
Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser
130 135 140
Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly
145 150 155 160
Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr
165 170 175
Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu
180 185 190
Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val
195 200 205
Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly
210 215 220
Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly
225 230 235 240
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly
245 250 255
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp
260 265 270
Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala
275 280 285
Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu
290 295 300
Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe
305 310 315 320
Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg
325 330 335
His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His
340 345 350
Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp
355 360 365
Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser
370 375 380
Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly
385 390 395 400
Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr
405 410 415
Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu
420 425 430
Val Gly Gly Gly Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys
435 440 445
Glu Met Asn Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr
450 455 460
Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala
465 470 475 480
Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn
485 490 495
Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe
500 505 510
Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His
515 520 525
Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys
530 535 540
Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His
545 550 555 560
Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile
565 570 575
Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly
580 585 590
Ile Ala Lys Ser Arg Lys Ser
595
<210> 200
<211> 434
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 200
Met Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His
1 5 10 15
Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe
20 25 30
Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly
50 55 60
Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly
65 70 75 80
Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg
85 90 95
His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu
100 105 110
Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp
115 120 125
Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly
130 135 140
Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His
145 150 155 160
Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe
165 170 175
Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala
180 185 190
Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly
195 200 205
Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly
210 215 220
Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg
225 230 235 240
His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu
245 250 255
Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp
260 265 270
Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Asn Ser Ser
275 280 285
Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp
290 295 300
Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His
305 310 315 320
Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln
325 330 335
Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln
340 345 350
Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile
355 360 365
Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe
370 375 380
Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu
385 390 395 400
Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His
405 410 415
Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg
420 425 430
Lys Ser
<210> 201
<211> 535
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 201
Met Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
1 5 10 15
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
20 25 30
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
35 40 45
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
50 55 60
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
65 70 75 80
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
85 90 95
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
100 105 110
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
115 120 125
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
130 135 140
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
145 150 155 160
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
165 170 175
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
180 185 190
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
195 200 205
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
210 215 220
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
225 230 235 240
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
245 250 255
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
260 265 270
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
275 280 285
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
290 295 300
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp
305 310 315 320
Ser Gly Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly
325 330 335
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ala Glu
340 345 350
Phe Arg His Asp Ser Gly Gly Gly Gly Asp Ile Ile Lys Leu Leu Asn
355 360 365
Glu Gln Val Asn Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys
370 375 380
Glu Met Asn Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr
385 390 395 400
Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala
405 410 415
Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn
420 425 430
Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe
435 440 445
Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His
450 455 460
Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys
465 470 475 480
Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His
485 490 495
Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile
500 505 510
Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly
515 520 525
Ile Ala Lys Ser Arg Lys Ser
530 535
<210> 202
<211> 614
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 202
Met Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly
1 5 10 15
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp
20 25 30
Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu
50 55 60
Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe
65 70 75 80
Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg
85 90 95
His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His
100 105 110
Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp
115 120 125
Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser
130 135 140
Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly
145 150 155 160
Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr
165 170 175
Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu
180 185 190
Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val
195 200 205
Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly
210 215 220
Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly
225 230 235 240
Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly
245 250 255
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp
260 265 270
Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala
275 280 285
Glu Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu
290 295 300
Phe Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe
305 310 315 320
Arg His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg
325 330 335
His Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His
340 345 350
Asp Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp
355 360 365
Ser Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser
370 375 380
Gly Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly
385 390 395 400
Tyr Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr
405 410 415
Glu Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu
420 425 430
Val Gly Gly Gly Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val
435 440 445
Gly Gly Gly Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu
450 455 460
Met Asn Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr
465 470 475 480
His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu
485 490 495
Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn
500 505 510
Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu
515 520 525
Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile
530 535 540
Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp
545 550 555 560
His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu
565 570 575
Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly
580 585 590
Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile
595 600 605
Ala Lys Ser Arg Lys Ser
610
<210> 203
<211> 201
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 203
Met Asp Ala Glu Phe Arg His Gly Gly Gly Thr Gln Cys Asn Val Asn
1 5 10 15
Pro Val Gln Ile Pro Lys Asp Trp Ile Thr Met His Arg Ser Cys Arg
20 25 30
Asn Ser Met Arg Gln Gln Ile Gln Met Glu Val Gly Ala Ser Leu Gln
35 40 45
Tyr Leu Ala Met Gly Ala His Phe Ser Lys Asp Val Val Asn Arg Pro
50 55 60
Gly Phe Ala Gln Leu Phe Phe Asp Ala Ala Ser Glu Glu Arg Glu His
65 70 75 80
Ala Met Lys Leu Ile Glu Tyr Leu Leu Met Arg Gly Glu Leu Thr Asn
85 90 95
Asp Val Ser Ser Leu Leu Gln Val Arg Pro Pro Thr Arg Ser Ser Trp
100 105 110
Lys Gly Gly Val Glu Ala Leu Glu His Ala Leu Ser Met Glu Ser Asp
115 120 125
Val Thr Lys Ser Ile Arg Asn Val Ile Lys Ala Cys Glu Asp Asp Ser
130 135 140
Glu Phe Asn Asp Tyr His Leu Val Asp Tyr Leu Thr Gly Asp Phe Leu
145 150 155 160
Glu Glu Gln Tyr Lys Gly Gln Arg Asp Leu Ala Gly Lys Ala Ser Thr
165 170 175
Leu Lys Lys Leu Met Asp Arg His Glu Ala Leu Gly Glu Phe Ile Phe
180 185 190
Asp Lys Lys Leu Leu Gly Ile Asp Val
195 200
<210> 204
<211> 210
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 204
Met Asp Ala Glu Phe Arg His Gly Gly Gly Gly Ile Thr Ser Asn Ser
1 5 10 15
Leu Ala Leu Pro Arg Cys Asn Ala Val Tyr Gly Glu Tyr Gly Ser His
20 25 30
Gly Asn Val Ala Thr Glu Leu Gln Ala Tyr Ala Lys Leu His Leu Glu
35 40 45
Arg Ser Tyr Asp Tyr Leu Leu Ser Ala Ala Tyr Phe Asn Asn Tyr Gln
50 55 60
Thr Asn Arg Ala Gly Phe Ser Lys Leu Phe Lys Lys Leu Ser Asp Glu
65 70 75 80
Ala Trp Ser Lys Thr Ile Asp Ile Ile Lys His Val Thr Lys Arg Gly
85 90 95
Asp Lys Met Asn Phe Asp Gln His Ser Thr Met Lys Thr Glu Arg Lys
100 105 110
Asn Tyr Thr Ala Glu Asn His Glu Leu Glu Ala Leu Ala Lys Ala Leu
115 120 125
Asp Thr Gln Lys Glu Leu Ala Glu Arg Ala Phe Tyr Ile His Arg Glu
130 135 140
Ala Thr Arg Asn Ser Gln His Leu His Asp Pro Glu Ile Ala Gln Tyr
145 150 155 160
Leu Glu Glu Glu Phe Ile Glu Asp His Ala Glu Lys Ile Arg Thr Leu
165 170 175
Ala Gly His Thr Ser Asp Leu Lys Lys Phe Ile Thr Ala Asn Asn Gly
180 185 190
His Asp Leu Ser Leu Ala Leu Tyr Val Phe Asp Glu Tyr Leu Gln Lys
195 200 205
Thr Val
210
<210> 205
<211> 219
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 205
Met Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His
1 5 10 15
Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Thr Gln Cys Asn
20 25 30
Val Asn Pro Val Gln Ile Pro Lys Asp Trp Ile Thr Met His Arg Ser
35 40 45
Cys Arg Asn Ser Met Arg Gln Gln Ile Gln Met Glu Val Gly Ala Ser
50 55 60
Leu Gln Tyr Leu Ala Met Gly Ala His Phe Ser Lys Asp Val Val Asn
65 70 75 80
Arg Pro Gly Phe Ala Gln Leu Phe Phe Asp Ala Ala Ser Glu Glu Arg
85 90 95
Glu His Ala Met Lys Leu Ile Glu Tyr Leu Leu Met Arg Gly Glu Leu
100 105 110
Thr Asn Asp Val Ser Ser Leu Leu Gln Val Arg Pro Pro Thr Arg Ser
115 120 125
Ser Trp Lys Gly Gly Val Glu Ala Leu Glu His Ala Leu Ser Met Glu
130 135 140
Ser Asp Val Thr Lys Ser Ile Arg Asn Val Ile Lys Ala Cys Glu Asp
145 150 155 160
Asp Ser Glu Phe Asn Asp Tyr His Leu Val Asp Tyr Leu Thr Gly Asp
165 170 175
Phe Leu Glu Glu Gln Tyr Lys Gly Gln Arg Asp Leu Ala Gly Lys Ala
180 185 190
Ser Thr Leu Lys Lys Leu Met Asp Arg His Glu Ala Leu Gly Glu Phe
195 200 205
Ile Phe Asp Lys Lys Leu Leu Gly Ile Asp Val
210 215
<210> 206
<211> 228
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 206
Met Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His
1 5 10 15
Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Gly Ile Thr Ser
20 25 30
Asn Ser Leu Ala Leu Pro Arg Cys Asn Ala Val Tyr Gly Glu Tyr Gly
35 40 45
Ser His Gly Asn Val Ala Thr Glu Leu Gln Ala Tyr Ala Lys Leu His
50 55 60
Leu Glu Arg Ser Tyr Asp Tyr Leu Leu Ser Ala Ala Tyr Phe Asn Asn
65 70 75 80
Tyr Gln Thr Asn Arg Ala Gly Phe Ser Lys Leu Phe Lys Lys Leu Ser
85 90 95
Asp Glu Ala Trp Ser Lys Thr Ile Asp Ile Ile Lys His Val Thr Lys
100 105 110
Arg Gly Asp Lys Met Asn Phe Asp Gln His Ser Thr Met Lys Thr Glu
115 120 125
Arg Lys Asn Tyr Thr Ala Glu Asn His Glu Leu Glu Ala Leu Ala Lys
130 135 140
Ala Leu Asp Thr Gln Lys Glu Leu Ala Glu Arg Ala Phe Tyr Ile His
145 150 155 160
Arg Glu Ala Thr Arg Asn Ser Gln His Leu His Asp Pro Glu Ile Ala
165 170 175
Gln Tyr Leu Glu Glu Glu Phe Ile Glu Asp His Ala Glu Lys Ile Arg
180 185 190
Thr Leu Ala Gly His Thr Ser Asp Leu Lys Lys Phe Ile Thr Ala Asn
195 200 205
Asn Gly His Asp Leu Ser Leu Ala Leu Tyr Val Phe Asp Glu Tyr Leu
210 215 220
Gln Lys Thr Val
225
<210> 207
<211> 282
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 207
Met Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His
1 5 10 15
Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe
20 25 30
Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly
50 55 60
Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly
65 70 75 80
Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Thr Gln Cys Asn Val
85 90 95
Asn Pro Val Gln Ile Pro Lys Asp Trp Ile Thr Met His Arg Ser Cys
100 105 110
Arg Asn Ser Met Arg Gln Gln Ile Gln Met Glu Val Gly Ala Ser Leu
115 120 125
Gln Tyr Leu Ala Met Gly Ala His Phe Ser Lys Asp Val Val Asn Arg
130 135 140
Pro Gly Phe Ala Gln Leu Phe Phe Asp Ala Ala Ser Glu Glu Arg Glu
145 150 155 160
His Ala Met Lys Leu Ile Glu Tyr Leu Leu Met Arg Gly Glu Leu Thr
165 170 175
Asn Asp Val Ser Ser Leu Leu Gln Val Arg Pro Pro Thr Arg Ser Ser
180 185 190
Trp Lys Gly Gly Val Glu Ala Leu Glu His Ala Leu Ser Met Glu Ser
195 200 205
Asp Val Thr Lys Ser Ile Arg Asn Val Ile Lys Ala Cys Glu Asp Asp
210 215 220
Ser Glu Phe Asn Asp Tyr His Leu Val Asp Tyr Leu Thr Gly Asp Phe
225 230 235 240
Leu Glu Glu Gln Tyr Lys Gly Gln Arg Asp Leu Ala Gly Lys Ala Ser
245 250 255
Thr Leu Lys Lys Leu Met Asp Arg His Glu Ala Leu Gly Glu Phe Ile
260 265 270
Phe Asp Lys Lys Leu Leu Gly Ile Asp Val
275 280
<210> 208
<211> 291
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 208
Met Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His
1 5 10 15
Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe
20 25 30
Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly
50 55 60
Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly
65 70 75 80
Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Gly Ile Thr Ser Asn
85 90 95
Ser Leu Ala Leu Pro Arg Cys Asn Ala Val Tyr Gly Glu Tyr Gly Ser
100 105 110
His Gly Asn Val Ala Thr Glu Leu Gln Ala Tyr Ala Lys Leu His Leu
115 120 125
Glu Arg Ser Tyr Asp Tyr Leu Leu Ser Ala Ala Tyr Phe Asn Asn Tyr
130 135 140
Gln Thr Asn Arg Ala Gly Phe Ser Lys Leu Phe Lys Lys Leu Ser Asp
145 150 155 160
Glu Ala Trp Ser Lys Thr Ile Asp Ile Ile Lys His Val Thr Lys Arg
165 170 175
Gly Asp Lys Met Asn Phe Asp Gln His Ser Thr Met Lys Thr Glu Arg
180 185 190
Lys Asn Tyr Thr Ala Glu Asn His Glu Leu Glu Ala Leu Ala Lys Ala
195 200 205
Leu Asp Thr Gln Lys Glu Leu Ala Glu Arg Ala Phe Tyr Ile His Arg
210 215 220
Glu Ala Thr Arg Asn Ser Gln His Leu His Asp Pro Glu Ile Ala Gln
225 230 235 240
Tyr Leu Glu Glu Glu Phe Ile Glu Asp His Ala Glu Lys Ile Arg Thr
245 250 255
Leu Ala Gly His Thr Ser Asp Leu Lys Lys Phe Ile Thr Ala Asn Asn
260 265 270
Gly His Asp Leu Ser Leu Ala Leu Tyr Val Phe Asp Glu Tyr Leu Gln
275 280 285
Lys Thr Val
290
<210> 209
<211> 372
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 209
Met Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His
1 5 10 15
Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe
20 25 30
Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly
50 55 60
Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly
65 70 75 80
Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg
85 90 95
His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu
100 105 110
Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp
115 120 125
Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly
130 135 140
Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His
145 150 155 160
Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe
165 170 175
Arg His Gly Gly Gly Thr Gln Cys Asn Val Asn Pro Val Gln Ile Pro
180 185 190
Lys Asp Trp Ile Thr Met His Arg Ser Cys Arg Asn Ser Met Arg Gln
195 200 205
Gln Ile Gln Met Glu Val Gly Ala Ser Leu Gln Tyr Leu Ala Met Gly
210 215 220
Ala His Phe Ser Lys Asp Val Val Asn Arg Pro Gly Phe Ala Gln Leu
225 230 235 240
Phe Phe Asp Ala Ala Ser Glu Glu Arg Glu His Ala Met Lys Leu Ile
245 250 255
Glu Tyr Leu Leu Met Arg Gly Glu Leu Thr Asn Asp Val Ser Ser Leu
260 265 270
Leu Gln Val Arg Pro Pro Thr Arg Ser Ser Trp Lys Gly Gly Val Glu
275 280 285
Ala Leu Glu His Ala Leu Ser Met Glu Ser Asp Val Thr Lys Ser Ile
290 295 300
Arg Asn Val Ile Lys Ala Cys Glu Asp Asp Ser Glu Phe Asn Asp Tyr
305 310 315 320
His Leu Val Asp Tyr Leu Thr Gly Asp Phe Leu Glu Glu Gln Tyr Lys
325 330 335
Gly Gln Arg Asp Leu Ala Gly Lys Ala Ser Thr Leu Lys Lys Leu Met
340 345 350
Asp Arg His Glu Ala Leu Gly Glu Phe Ile Phe Asp Lys Lys Leu Leu
355 360 365
Gly Ile Asp Val
370
<210> 210
<211> 381
<212> PRT
<213> 合成序列(Synthetic Sequence)
<400> 210
Met Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His
1 5 10 15
Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe
20 25 30
Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala
35 40 45
Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly
50 55 60
Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly
65 70 75 80
Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg
85 90 95
His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu
100 105 110
Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp
115 120 125
Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly
130 135 140
Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe Arg His
145 150 155 160
Gly Gly Gly Asp Ala Glu Phe Arg His Gly Gly Gly Asp Ala Glu Phe
165 170 175
Arg His Gly Gly Gly Gly Ile Thr Ser Asn Ser Leu Ala Leu Pro Arg
180 185 190
Cys Asn Ala Val Tyr Gly Glu Tyr Gly Ser His Gly Asn Val Ala Thr
195 200 205
Glu Leu Gln Ala Tyr Ala Lys Leu His Leu Glu Arg Ser Tyr Asp Tyr
210 215 220
Leu Leu Ser Ala Ala Tyr Phe Asn Asn Tyr Gln Thr Asn Arg Ala Gly
225 230 235 240
Phe Ser Lys Leu Phe Lys Lys Leu Ser Asp Glu Ala Trp Ser Lys Thr
245 250 255
Ile Asp Ile Ile Lys His Val Thr Lys Arg Gly Asp Lys Met Asn Phe
260 265 270
Asp Gln His Ser Thr Met Lys Thr Glu Arg Lys Asn Tyr Thr Ala Glu
275 280 285
Asn His Glu Leu Glu Ala Leu Ala Lys Ala Leu Asp Thr Gln Lys Glu
290 295 300
Leu Ala Glu Arg Ala Phe Tyr Ile His Arg Glu Ala Thr Arg Asn Ser
305 310 315 320
Gln His Leu His Asp Pro Glu Ile Ala Gln Tyr Leu Glu Glu Glu Phe
325 330 335
Ile Glu Asp His Ala Glu Lys Ile Arg Thr Leu Ala Gly His Thr Ser
340 345 350
Asp Leu Lys Lys Phe Ile Thr Ala Asn Asn Gly His Asp Leu Ser Leu
355 360 365
Ala Leu Tyr Val Phe Asp Glu Tyr Leu Gln Lys Thr Val
370 375 380
Claims (11)
1.一种重组蛋白，其由N个拷贝的Aβ1-m肽和铁蛋白融合而成，其中所述N个拷贝的Aβ1-m肽与所述铁蛋白的氨基端融合，并且N为选自1-30的整数，m为选自6-15的整数。
2.权利要求1所述的重组蛋白，其中所述铁蛋白为幽门螺旋杆菌铁蛋白或昆虫粉纹夜蛾分泌铁蛋白，其中昆虫粉纹夜蛾分泌铁蛋白由H链和L链组成；更优选地，幽门螺旋杆菌铁蛋白具有如SEQ ID NO：1所示的氨基酸序列，昆虫粉纹夜蛾分泌铁蛋白H链具有如SEQ IDNO：2所示的氨基酸序列，且昆虫粉纹夜蛾分泌铁蛋白L链具有如SEQ ID NO：3所示的氨基酸序列。
3.权利要求1或2所述的重组蛋白，其中所述Aβ1-m肽是人、小鼠、灵长类、兔、光滑爪蟾、大鼠、豚鼠的Aβ1-m肽；优选地，m为6、9或12，即Aβ1-6肽、Aβ1-9肽、Aβ1-12肽是完整的Aβ42蛋白1-6位、1-9位、1-12位氨基酸组成的多肽；更优选地，人、小鼠、灵长类、兔、光滑爪蟾、大鼠、豚鼠的Aβ1-12肽具有如SEQ ID NO：4-SEQ ID NO：10所示的氨基酸序列。
4.权利要求1或2所述的重组蛋白，其中所述Aβ1-m肽之间可通过氨基酸接头相连；更优选地，所述氨基酸接头为(Gly)n，优选n为1-10，更优选n＝3。
5.权利要求1所述的重组蛋白，所述重组蛋白包含SEQ ID NO：113至SEQ ID NO：210中任一项所示的氨基酸序列；优选地，所述重组蛋白包含SEQ ID NO：113、SEQ ID NO：119、SEQID NO：120、SEQ ID NO：121、SEQ ID NO：129、SEQ ID NO：140、SEQ ID NO：141、SEQ ID NO：142、SEQ ID NO：147、SEQ ID NO：155、SEQ ID NO：164、SEQ ID NO：170、SEQ ID NO：171、SEQID NO：172、SEQ ID NO：182、SEQ ID NO：200中任一项所示的氨基酸序列。
6.一种纳米颗粒，其由权利要求1-5中任一项所述的重组蛋白组成；优选地，所述纳米颗粒是24聚体。
7.一种核酸，其包含编码权利要求1-5中任一项所述的重组蛋白的核苷酸序列。
8.权利要求7所述的核酸，所述核酸包含SEQ ID NO：15至SEQ ID NO：112中任一项所示的核苷酸序列；优选地，所述核酸包含SEQ ID NO：15、SEQ ID NO：21、SEQ ID NO：22、SEQ IDNO：23、SEQ ID NO：31、SEQ ID NO：42、SEQ ID NO：43、SEQ ID NO：44、SEQ ID NO：49、SEQ IDNO：57、SEQ ID NO：66、SEQ ID NO：72、SEQ ID NO：73、SEQ ID NO：74、SEQ ID NO：84、SEQ IDNO：102中任一项所示的核苷酸序列。
9.一种疫苗组合物，其包含权利要求1-5中任一项所述的重组蛋白或权利要求6所述的纳米颗粒以及可药用的载体；优选地，所述可药用的载体为佐剂；更优选地，所述佐剂包括MF59、CpG、和/或氢氧化铝；最优选地，所述佐剂为MF59和CpG。
10.权利要求1-5中任一项所述的重组蛋白或权利要求6所述的纳米颗粒用于制备在受试者中治疗或预防阿尔茨海默病的药物的用途；
优选地，所述受试者是哺乳动物；更优选地，所述受试者是人；
优选地，所述药物为疫苗组合物；更优选地，所述疫苗组合物通过皮下途径或肌肉途径给药；最优选地，所述疫苗组合物通过肌肉途径给药。
11.一种制备权利要求6所述的纳米颗粒的方法，包括：
(1)合成DNA片段，其编码权利要求1-5中任一项所述的重组蛋白；
(2)将所述DNA片段与载体连接，获得重组表达载体；和
(3)将所述重组表达载体转入大肠杆菌细胞或HEK 293F细胞内，从而获得稳定表达的重组蛋白并自组装形成纳米颗粒；优选地，所述纳米颗粒是24聚体形式；
优选地，所述DNA片段包含SEQ ID NO：15至SEQ ID NO：112中任一项所示的核苷酸序列；
优选地，所述方法还包括蛋白纯化步骤；更优选地，所述蛋白纯化步骤包括亲和层析和滤膜除菌。
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