CN117241816A - 用于新生儿缺氧缺血性脑病的神经保护的组合物和方法 - Google Patents

用于新生儿缺氧缺血性脑病的神经保护的组合物和方法 Download PDF

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Publication number
CN117241816A
CN117241816A CN202180093022.5A CN202180093022A CN117241816A CN 117241816 A CN117241816 A CN 117241816A CN 202180093022 A CN202180093022 A CN 202180093022A CN 117241816 A CN117241816 A CN 117241816A
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CN
China
Prior art keywords
emulsion
delivery
hours
dha
weight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202180093022.5A
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English (en)
Chinese (zh)
Inventor
理查德·J·戴克尔鲍姆
海尔德·泽波利
索伦·韦斯·达尔
瓦迪姆·S·天恩
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Columbia University in the City of New York
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Columbia University in the City of New York
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Filing date
Publication date
Application filed by Columbia University in the City of New York filed Critical Columbia University in the City of New York
Publication of CN117241816A publication Critical patent/CN117241816A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
CN202180093022.5A 2020-12-07 2021-12-07 用于新生儿缺氧缺血性脑病的神经保护的组合物和方法 Pending CN117241816A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063122198P 2020-12-07 2020-12-07
US63/122,198 2020-12-07
PCT/US2021/062102 WO2022125484A1 (en) 2020-12-07 2021-12-07 Compositions and methods for neuroprotection in neonatal hypoxic-ischemic encephalopathy

Publications (1)

Publication Number Publication Date
CN117241816A true CN117241816A (zh) 2023-12-15

Family

ID=81973945

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180093022.5A Pending CN117241816A (zh) 2020-12-07 2021-12-07 用于新生儿缺氧缺血性脑病的神经保护的组合物和方法

Country Status (5)

Country Link
US (1) US20240050391A1 (https=)
EP (1) EP4255459A4 (https=)
JP (1) JP2023552450A (https=)
CN (1) CN117241816A (https=)
WO (1) WO2022125484A1 (https=)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050027004A1 (en) * 1993-06-09 2005-02-03 Martek Biosciences Corporation Methods of treating senile dementia and Alzheimer's diseases using docosahexaenoic acid and arachidonic acid compositions
WO2014130746A1 (en) * 2013-02-20 2014-08-28 The Trustees Of Columbia University In The City Of New York Use of an omega-3 lipid-based emulsion for protecting human organs from ischemic injury
US20070149617A1 (en) * 2005-11-14 2007-06-28 Deckelbaum Richard J Use of an omega-3 lipid-based emulsion following ischemic injury to provide protection and recovery in human organs
BR112014021390A2 (pt) * 2012-02-29 2019-09-24 Braun Melsungen Ag emulsão do tipo óleo em água contendo hormônio e composição farmacêutica
EP3068386A1 (en) * 2013-11-12 2016-09-21 Abbott Laboratories Uses of nutritional compositions including natural vitamin e, and polyunsaturated fatty acid
ES3041336T3 (en) * 2020-04-15 2025-11-11 Univ Columbia Stable diglyceride emulsions and methods for treating organ injury

Also Published As

Publication number Publication date
US20240050391A1 (en) 2024-02-15
EP4255459A4 (en) 2024-10-30
WO2022125484A1 (en) 2022-06-16
EP4255459A1 (en) 2023-10-11
JP2023552450A (ja) 2023-12-15

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