JP2023552450A - 新生児低酸素性虚血性脳症における神経保護のための組成物及び方法 - Google Patents

新生児低酸素性虚血性脳症における神経保護のための組成物及び方法 Download PDF

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JP2023552450A
JP2023552450A JP2023534312A JP2023534312A JP2023552450A JP 2023552450 A JP2023552450 A JP 2023552450A JP 2023534312 A JP2023534312 A JP 2023534312A JP 2023534312 A JP2023534312 A JP 2023534312A JP 2023552450 A JP2023552450 A JP 2023552450A
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emulsion
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JP2023552450A5 (https=
Inventor
リチャード ジェイ． デッケルバウム
ヒュルデ ジルポリ
ソーレン ヴェイス ダール
ヴァディム エス． テン
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Columbia University in the City of New York
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Columbia University in the City of New York
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Publication of JP2023552450A5 publication Critical patent/JP2023552450A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
JP2023534312A 2020-12-07 2021-12-07 新生児低酸素性虚血性脳症における神経保護のための組成物及び方法 Pending JP2023552450A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063122198P 2020-12-07 2020-12-07
US63/122,198 2020-12-07
PCT/US2021/062102 WO2022125484A1 (en) 2020-12-07 2021-12-07 Compositions and methods for neuroprotection in neonatal hypoxic-ischemic encephalopathy

Publications (2)

Publication Number Publication Date
JP2023552450A true JP2023552450A (ja) 2023-12-15
JP2023552450A5 JP2023552450A5 (https=) 2024-12-06

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JP2023534312A Pending JP2023552450A (ja) 2020-12-07 2021-12-07 新生児低酸素性虚血性脳症における神経保護のための組成物及び方法

Country Status (5)

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US (1) US20240050391A1 (https=)
EP (1) EP4255459A4 (https=)
JP (1) JP2023552450A (https=)
CN (1) CN117241816A (https=)
WO (1) WO2022125484A1 (https=)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014130746A1 (en) * 2013-02-20 2014-08-28 The Trustees Of Columbia University In The City Of New York Use of an omega-3 lipid-based emulsion for protecting human organs from ischemic injury
JP2023521917A (ja) * 2020-04-15 2023-05-25 ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク 臓器損傷を治療するための安定なジグリセリド乳剤および方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050027004A1 (en) * 1993-06-09 2005-02-03 Martek Biosciences Corporation Methods of treating senile dementia and Alzheimer's diseases using docosahexaenoic acid and arachidonic acid compositions
US20070149617A1 (en) * 2005-11-14 2007-06-28 Deckelbaum Richard J Use of an omega-3 lipid-based emulsion following ischemic injury to provide protection and recovery in human organs
BR112014021390A2 (pt) * 2012-02-29 2019-09-24 Braun Melsungen Ag emulsão do tipo óleo em água contendo hormônio e composição farmacêutica
EP3068386A1 (en) * 2013-11-12 2016-09-21 Abbott Laboratories Uses of nutritional compositions including natural vitamin e, and polyunsaturated fatty acid

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014130746A1 (en) * 2013-02-20 2014-08-28 The Trustees Of Columbia University In The City Of New York Use of an omega-3 lipid-based emulsion for protecting human organs from ischemic injury
JP2023521917A (ja) * 2020-04-15 2023-05-25 ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク 臓器損傷を治療するための安定なジグリセリド乳剤および方法

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BRAIN, vol. 141, JPN6025036441, 2018, pages 3130 - 3143, ISSN: 0005678124 *
J. NAT. PROD., vol. 77(4), JPN6025036442, 2014, pages 910 - 916, ISSN: 0005678125 *
PEDIATRICS AND NEONATOLOGY, vol. 58, JPN6025036440, 2017, pages 475 - 483, ISSN: 0005822492 *
PLOS ONE, vol. 11(8), JPN6025036437, 2016, pages 0160870 - 1, ISSN: 0005822490 *
PLOS ONE, vol. 8(2), JPN6025036439, 2013, pages 56233 - 1, ISSN: 0005822491 *
THE FASEB JOURNAL, vol. 31(S1), JPN6025036443, 2018, pages 431 - 6, ISSN: 0005678126 *

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Publication number Publication date
US20240050391A1 (en) 2024-02-15
EP4255459A4 (en) 2024-10-30
CN117241816A (zh) 2023-12-15
WO2022125484A1 (en) 2022-06-16
EP4255459A1 (en) 2023-10-11

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