CN117222743A - 向导RNA设计和用于无Tracr V型Cas系统的复合物 - Google Patents

向导RNA设计和用于无Tracr V型Cas系统的复合物 Download PDF

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Publication number
CN117222743A
CN117222743A CN202280019316.8A CN202280019316A CN117222743A CN 117222743 A CN117222743 A CN 117222743A CN 202280019316 A CN202280019316 A CN 202280019316A CN 117222743 A CN117222743 A CN 117222743A
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grna
ligand binding
complex
group
sequence
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Chinese (zh)
Inventor
K·D·马歇尔
H·B·马查多
E·安德森
A·黑尔
A·史密斯
K·亨普希尔
A·考夫曼
L·南蒂
M·D·拉什顿
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HAPLOGEN GENOMICS GmbH
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HAPLOGEN GENOMICS GmbH
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CN202280019316.8A 2021-01-05 2022-01-05 向导RNA设计和用于无Tracr V型Cas系统的复合物 Pending CN117222743A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163133942P 2021-01-05 2021-01-05
US63/133,942 2021-01-05
PCT/US2022/011289 WO2022150367A1 (en) 2021-01-05 2022-01-05 Guide rna designs and complexes for tracr-less type v cas systems

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CN117222743A true CN117222743A (zh) 2023-12-12

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US (1) US20240067983A1 (https=)
EP (1) EP4274902A4 (https=)
JP (1) JP2024502348A (https=)
CN (1) CN117222743A (https=)
CA (1) CA3207138A1 (https=)
WO (1) WO2022150367A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020051562A2 (en) 2018-09-07 2020-03-12 Beam Therapeutics Inc. Compositions and methods for improving base editing
EP3847254A4 (en) 2018-09-07 2022-08-10 Beam Therapeutics Inc. COMPOSITIONS AND METHODS FOR DELIVERING A NUCLEOBASE EDITING SYSTEM
AU2020215730A1 (en) 2019-01-31 2021-07-29 Beam Therapeutics Inc. Nucleobase editors having reduced non-target deamination and assays for characterizing nucleobase editors
CN120174005A (zh) 2019-02-13 2025-06-20 比姆医疗股份有限公司 具有用于修饰靶标序列中核碱基的腺苷脱氨酶碱基编辑器的经修饰的免疫细胞
EP4034138A4 (en) 2019-09-27 2024-07-31 Beam Therapeutics, Inc. COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIQUID CANCERS
CA3196831A1 (en) 2020-09-25 2022-03-31 Beam Therapeutics Inc. Fratricide resistant modified immune cells and methods of using the same
WO2025212120A1 (en) * 2024-04-05 2025-10-09 Arbor Biotechnologies, Inc. Chemical modifications of guide rnas for crispr nucleases

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7044373B2 (ja) * 2015-07-15 2022-03-30 ラトガース，ザ ステート ユニバーシティ オブ ニュージャージー ヌクレアーゼ非依存的な標的化遺伝子編集プラットフォームおよびその用途
EP4485466A3 (en) * 2016-08-17 2025-04-02 The Broad Institute Inc. Novel crispr enzymes and systems
AU2019265019B2 (en) * 2018-05-11 2025-11-06 Beam Therapeutics Inc. Methods of substituting pathogenic amino acids using programmable base editor systems
MX2021010559A (es) * 2019-03-07 2021-12-15 Univ California Polipéptidos efectores de crispr-cas y métodos de uso de estos.
US12286633B2 (en) * 2019-12-17 2025-04-29 University Of Maryland, College Park Compositions and methods for genome editing in plants

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Publication number Publication date
US20240067983A1 (en) 2024-02-29
WO2022150367A1 (en) 2022-07-14
EP4274902A1 (en) 2023-11-15
EP4274902A4 (en) 2025-04-16
JP2024502348A (ja) 2024-01-18
CA3207138A1 (en) 2022-07-14

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