CN117202939A - 检测宫颈癌 - Google Patents
检测宫颈癌 Download PDFInfo
- Publication number
- CN117202939A CN117202939A CN202280023043.4A CN202280023043A CN117202939A CN 117202939 A CN117202939 A CN 117202939A CN 202280023043 A CN202280023043 A CN 202280023043A CN 117202939 A CN117202939 A CN 117202939A
- Authority
- CN
- China
- Prior art keywords
- methylation
- sample
- max
- dna
- cervical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/4833—Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6851—Quantitative amplification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2521/00—Reaction characterised by the enzymatic activity
- C12Q2521/30—Phosphoric diester hydrolysing, i.e. nuclease
- C12Q2521/331—Methylation site specific nuclease
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2523/00—Reactions characterised by treatment of reaction samples
- C12Q2523/10—Characterised by chemical treatment
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Food Science & Technology (AREA)
- Optics & Photonics (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- General Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163157437P | 2021-03-05 | 2021-03-05 | |
| US63/157,437 | 2021-03-05 | ||
| PCT/US2022/019010 WO2022187695A1 (en) | 2021-03-05 | 2022-03-04 | Detecting cervical cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN117202939A true CN117202939A (zh) | 2023-12-08 |
Family
ID=83155601
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202280023043.4A Pending CN117202939A (zh) | 2021-03-05 | 2022-03-04 | 检测宫颈癌 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20240052425A1 (https=) |
| EP (1) | EP4301419A4 (https=) |
| JP (1) | JP2024509851A (https=) |
| KR (1) | KR20230154433A (https=) |
| CN (1) | CN117202939A (https=) |
| AU (1) | AU2022231036A1 (https=) |
| CA (1) | CA3211005A1 (https=) |
| WO (1) | WO2022187695A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2816122A1 (en) | 2008-02-15 | 2014-12-24 | Mayo Foundation For Medical Education And Research | Detecting neoplasm from a stool sample |
| US8361720B2 (en) | 2010-11-15 | 2013-01-29 | Exact Sciences Corporation | Real time cleavage assay |
| CA2902916C (en) | 2013-03-14 | 2018-08-28 | Mayo Foundation For Medical Education And Research | Detecting neoplasm |
| CN120700143A (zh) | 2014-03-31 | 2025-09-26 | 梅奥医学教育和研究基金会 | 检测结直肠赘生物 |
| US10184154B2 (en) | 2014-09-26 | 2019-01-22 | Mayo Foundation For Medical Education And Research | Detecting cholangiocarcinoma |
| US10435755B2 (en) | 2015-03-27 | 2019-10-08 | Exact Sciences Development Company, Llc | Detecting esophageal disorders |
| CN114574585A (zh) | 2015-08-31 | 2022-06-03 | 梅约医药教育及研究基金会 | 检测胃肿瘤 |
| CN108350485A (zh) | 2015-10-30 | 2018-07-31 | 精密科学发展有限责任公司 | 血浆dna的多重扩增检测测定以及分离和检测 |
| CN109563546B (zh) | 2016-05-05 | 2022-09-09 | 精密科学发展有限责任公司 | 通过分析甲基化dna来检测肺肿瘤 |
| KR102892245B1 (ko) | 2017-01-27 | 2025-11-27 | 이그젝트 싸이언스 디블롭먼트 컴패니, 엘엘씨 | 메틸화된 dna 분석에 의한 결장 신조직형성의 검출 |
| JP7277460B2 (ja) | 2017-11-30 | 2023-05-19 | マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチ | 乳癌の検出 |
| US10648025B2 (en) | 2017-12-13 | 2020-05-12 | Exact Sciences Development Company, Llc | Multiplex amplification detection assay II |
| CA3127329A1 (en) | 2019-01-24 | 2020-07-30 | Mayo Foundation For Medical Education And Research | Detecting endometrial cancer |
| US11702704B2 (en) | 2019-10-31 | 2023-07-18 | Mayo Foundation For Medical Education And Research | Detecting ovarian cancer |
| CN116179698B (zh) * | 2022-12-02 | 2025-08-01 | 武汉艾米森生命科技有限公司 | 检测目标区域的甲基化水平的试剂在制备子宫内膜癌诊断产品中的应用 |
| CN117947169B (zh) * | 2024-02-02 | 2024-08-20 | 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） | 早期检测子宫内膜癌的甲基化基因标志物组合、多重pcr检测试剂盒及其应用 |
| CN118638922B (zh) * | 2024-03-15 | 2025-05-23 | 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） | 用于子宫内膜癌早期检测的引物探针组合、甲基化检测试剂盒及其应用 |
| CN117904303B (zh) * | 2024-03-18 | 2024-06-18 | 湖南宏雅基因技术有限公司 | Sorcs1基因甲基化和pax1基因甲基化联合诊断的检测引物探针组在制备宫颈癌诊断产品中的应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1436408A4 (en) * | 2001-09-19 | 2006-12-13 | Univ Queensland | METHOD OF IDENTIFYING EFFECTOR MOLECULES FOR GENE NETWORK INTEGRATION |
| WO2006004597A2 (en) * | 2004-06-01 | 2006-01-12 | University Of Southern California | Association of breast cancer dna methylation profiles with hormone receptor status and response to tamoxifen |
| US8257929B2 (en) * | 2006-10-20 | 2012-09-04 | University Of Miami | Gene expression profiling of Parkinson's Disease |
| US20090075265A1 (en) * | 2007-02-02 | 2009-03-19 | Orion Genomics Llc | Gene methylation in thyroid cancer diagnosis |
| ITTO20070201A1 (it) * | 2007-03-19 | 2007-10-08 | Elena Miotto | Nuovi marcatori di metilazione del dna utili per la diagnosi di malattie neoplastiche |
| US8962247B2 (en) * | 2008-09-16 | 2015-02-24 | Sequenom, Inc. | Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses |
| WO2010062914A1 (en) * | 2008-11-26 | 2010-06-03 | The Johns Hopkins University | Methods for identifying cancer risk |
| GB201102014D0 (en) * | 2011-02-04 | 2011-03-23 | Ucl Business Plc | Method for predicting risk of developing cancer |
| PT105553B (pt) * | 2011-03-01 | 2020-04-20 | Infogene Lda | Dispositivo portátil para o armazenamento, transporte e recuperação de material biológico |
| CN120700143A (zh) * | 2014-03-31 | 2025-09-26 | 梅奥医学教育和研究基金会 | 检测结直肠赘生物 |
| CN111868260B (zh) * | 2017-08-07 | 2025-02-21 | 约翰斯霍普金斯大学 | 用于评估和治疗癌症的方法和材料 |
| WO2019160994A1 (en) * | 2018-02-14 | 2019-08-22 | Bluestar Genomics, Inc. | Methods for the epigenetic analysis of dna, particularly cell-free dna |
| BR112021010640A2 (pt) * | 2018-12-04 | 2021-09-08 | Hkg Epitherapeutics Limited | Método in-vitro para obter preditores precoces de câncer cervical, painel de biomarcadores de metilação de dna para rastreamento e detecção precoce de câncer cervical, combinação de biomarcadores de metilação de dna para rastreamento e detecção precoce de câncer cervical, kit para detecção de câncer cervical, uso de equação de regressão linear multivariável ou análise de rede neura, uso de ensaios decaracterísticas de operação do receptor (roc), e método implementado por computador para obter biomarcadores de metilação de dna candidatos para detecção precoce dediagnóstico de câncer cervical |
| JP2022530920A (ja) * | 2019-05-03 | 2022-07-04 | コーネル ユニバーシティー | 核酸配列の変異、発現、スプライスバリアント、転座、コピー数、またはメチル化変化を特定及び定量するためのマーカー |
| US11396679B2 (en) * | 2019-05-31 | 2022-07-26 | Universal Diagnostics, S.L. | Detection of colorectal cancer |
-
2022
- 2022-03-04 CA CA3211005A patent/CA3211005A1/en active Pending
- 2022-03-04 EP EP22764185.9A patent/EP4301419A4/en active Pending
- 2022-03-04 WO PCT/US2022/019010 patent/WO2022187695A1/en not_active Ceased
- 2022-03-04 CN CN202280023043.4A patent/CN117202939A/zh active Pending
- 2022-03-04 US US18/279,980 patent/US20240052425A1/en active Pending
- 2022-03-04 JP JP2023553602A patent/JP2024509851A/ja active Pending
- 2022-03-04 KR KR1020237031826A patent/KR20230154433A/ko active Pending
- 2022-03-04 AU AU2022231036A patent/AU2022231036A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP4301419A4 (en) | 2025-05-21 |
| WO2022187695A1 (en) | 2022-09-09 |
| EP4301419A1 (en) | 2024-01-10 |
| KR20230154433A (ko) | 2023-11-08 |
| CA3211005A1 (en) | 2022-09-09 |
| AU2022231036A1 (en) | 2023-09-21 |
| JP2024509851A (ja) | 2024-03-05 |
| US20240052425A1 (en) | 2024-02-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |