CN117180183A - Skin antibacterial paste containing lindane and preparation method and application thereof - Google Patents
Skin antibacterial paste containing lindane and preparation method and application thereof Download PDFInfo
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- CN117180183A CN117180183A CN202311259635.9A CN202311259635A CN117180183A CN 117180183 A CN117180183 A CN 117180183A CN 202311259635 A CN202311259635 A CN 202311259635A CN 117180183 A CN117180183 A CN 117180183A
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- lindane
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- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 61
- JLYXXMFPNIAWKQ-GNIYUCBRSA-N gamma-hexachlorocyclohexane Chemical compound Cl[C@H]1[C@H](Cl)[C@@H](Cl)[C@@H](Cl)[C@H](Cl)[C@H]1Cl JLYXXMFPNIAWKQ-GNIYUCBRSA-N 0.000 title claims abstract description 41
- JLYXXMFPNIAWKQ-UHFFFAOYSA-N gamma-hexachlorocyclohexane Natural products ClC1C(Cl)C(Cl)C(Cl)C(Cl)C1Cl JLYXXMFPNIAWKQ-UHFFFAOYSA-N 0.000 title claims abstract description 31
- 229960002809 lindane Drugs 0.000 title claims abstract description 31
- 238000002360 preparation method Methods 0.000 title claims abstract description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 95
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 54
- 229960002152 chlorhexidine acetate Drugs 0.000 claims abstract description 36
- MCSINKKTEDDPNK-UHFFFAOYSA-N propyl propionate Chemical compound CCCOC(=O)CC MCSINKKTEDDPNK-UHFFFAOYSA-N 0.000 claims abstract description 36
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims abstract description 35
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 claims abstract description 21
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 claims abstract description 21
- 235000021355 Stearic acid Nutrition 0.000 claims abstract description 20
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims abstract description 20
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims abstract description 20
- 239000008117 stearic acid Substances 0.000 claims abstract description 20
- 239000004094 surface-active agent Substances 0.000 claims abstract description 20
- 229960000490 permethrin Drugs 0.000 claims abstract description 19
- RLLPVAHGXHCWKJ-UHFFFAOYSA-N permethrin Chemical compound CC1(C)C(C=C(Cl)Cl)C1C(=O)OCC1=CC=CC(OC=2C=CC=CC=2)=C1 RLLPVAHGXHCWKJ-UHFFFAOYSA-N 0.000 claims abstract description 19
- 239000003871 white petrolatum Substances 0.000 claims abstract description 18
- 229940075507 glyceryl monostearate Drugs 0.000 claims abstract description 17
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 claims abstract description 17
- 239000006071 cream Substances 0.000 claims abstract description 14
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 claims abstract description 12
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 claims abstract description 12
- 238000002156 mixing Methods 0.000 claims description 30
- 238000003756 stirring Methods 0.000 claims description 22
- 235000011187 glycerol Nutrition 0.000 claims description 20
- 239000000463 material Substances 0.000 claims description 19
- 238000010438 heat treatment Methods 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 18
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 11
- GYCKQBWUSACYIF-UHFFFAOYSA-N o-hydroxybenzoic acid ethyl ester Natural products CCOC(=O)C1=CC=CC=C1O GYCKQBWUSACYIF-UHFFFAOYSA-N 0.000 claims description 9
- 238000004945 emulsification Methods 0.000 claims description 8
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 5
- 208000030852 Parasitic disease Diseases 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 3
- 230000001804 emulsifying effect Effects 0.000 claims description 3
- 230000001954 sterilising effect Effects 0.000 abstract description 26
- 230000007794 irritation Effects 0.000 abstract description 3
- 239000012071 phase Substances 0.000 description 91
- 238000004659 sterilization and disinfection Methods 0.000 description 22
- 238000012360 testing method Methods 0.000 description 17
- 239000000203 mixture Substances 0.000 description 10
- 238000006243 chemical reaction Methods 0.000 description 6
- 238000001816 cooling Methods 0.000 description 6
- 239000000645 desinfectant Substances 0.000 description 6
- 241000222122 Candida albicans Species 0.000 description 5
- 241000191967 Staphylococcus aureus Species 0.000 description 5
- 239000004480 active ingredient Substances 0.000 description 5
- 229940095731 candida albicans Drugs 0.000 description 5
- 238000005259 measurement Methods 0.000 description 5
- 239000008213 purified water Substances 0.000 description 5
- 241000588724 Escherichia coli Species 0.000 description 4
- 229910052785 arsenic Inorganic materials 0.000 description 3
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 3
- 229910052753 mercury Inorganic materials 0.000 description 3
- 239000013642 negative control Substances 0.000 description 3
- 239000002674 ointment Substances 0.000 description 3
- 208000017520 skin disease Diseases 0.000 description 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 206010035148 Plague Diseases 0.000 description 2
- 206010040880 Skin irritation Diseases 0.000 description 2
- 241000607479 Yersinia pestis Species 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- 230000036281 parasite infection Effects 0.000 description 2
- 238000011056 performance test Methods 0.000 description 2
- 230000036556 skin irritation Effects 0.000 description 2
- 231100000475 skin irritation Toxicity 0.000 description 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- 241000238876 Acari Species 0.000 description 1
- 206010063409 Acarodermatitis Diseases 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 208000037273 Pathologic Processes Diseases 0.000 description 1
- 241000447727 Scabies Species 0.000 description 1
- 206010052891 Skin bacterial infection Diseases 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 125000003342 alkenyl group Chemical group 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 230000001050 lubricating effect Effects 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 230000009054 pathological process Effects 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 208000005687 scabies Diseases 0.000 description 1
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
- 235000019345 sodium thiosulphate Nutrition 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 239000012137 tryptone Substances 0.000 description 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention relates to the technical field of skin antibacterial preparations, in particular to a skin antibacterial paste containing lindane and a preparation method and application thereof. The invention provides a skin antibacterial paste containing woody denier, which comprises the following components in parts by mass: 3-5 parts of chlorhexidine acetate, 40-60 parts of permethrin, 90-110 parts of stearic acid, 72-88 parts of white vaseline, 57-71 parts of glyceryl monostearate, 9-11 parts of surfactant, 72-88 parts of glycerol, 0.9-1.1 parts of ethylparaben and 550-680 parts of water. The lindane skin antibacterial cream solves the problem of intolerable smell of the sterilizing cream circulated in the market, has no irritation to skin, and is safe and efficient.
Description
Technical Field
The invention relates to the technical field of skin antibacterial preparations, in particular to a skin antibacterial paste containing lindane and a preparation method and application thereof.
Background
Skin diseases are common diseases which seriously affect the health of people, and are caused by pathological processes and corresponding clinical manifestations of the skin (including hair and nails) which are changed in morphology, structure and function after the skin (including hair and nails) is affected by internal and external factors. One cause of skin diseases is due to fungal, skin bacterial infections, etc. These skin diseases often plague people's happy lives, and plague people's mind and spirit. The sterilizing cream which is circulated in the market at present is cream containing sulfur, but has an odor which is difficult to tolerate, and the sterilizing effect is generally not accepted by consumers.
Disclosure of Invention
The invention aims to provide a lindane skin antibacterial paste, a preparation method and application thereof, and the lindane skin antibacterial paste solves the problem of intolerable smell of sterilizing cream circulated in the market, has no irritation to skin, and is safe and efficient.
In order to achieve the above object, the present invention provides the following technical solutions:
the invention provides a skin antibacterial paste containing woody denier, which comprises the following components in parts by mass: 3-5 parts of chlorhexidine acetate, 40-60 parts of permethrin, 90-110 parts of stearic acid, 72-88 parts of white vaseline, 57-71 parts of glyceryl monostearate, 9-11 parts of surfactant, 72-88 parts of glycerol, 0.9-1.1 parts of ethylparaben and 550-680 parts of water.
Preferably, the surfactant comprises sodium dodecyl sulfate and/or triethanolamine.
Preferably, the composition comprises the following components: 4 parts of chlorhexidine acetate, 50 parts of permethrin, 100 parts of stearic acid, 80 parts of white vaseline, 64 parts of glyceryl monostearate, 10 parts of a surfactant, 80 parts of glycerin, 1 part of ethylparaben and 611 parts of water.
The invention also provides a preparation method of the lindane skin antibacterial paste, which comprises the following steps:
mixing water, glycerol, surfactant, ethyl hydroxy benzoate and chlorhexidine acetate for the first time to obtain a water phase;
mixing stearic acid, glyceryl monostearate, white vaseline and permethrin to obtain oil phase;
and thirdly mixing the water phase and the oil phase, and emulsifying to obtain the lindane skin antibacterial paste.
Preferably, the first mixing comprises mixing water, glycerin, a surfactant and ethyl hydroxy benzoate, heating, and adding chlorhexidine acetate.
Preferably, the heating temperature is 75-87 ℃;
adding the chlorhexidine acetate under stirring; the stirring speed is 300-600 rpm, and the stirring time is 20-30 min.
Preferably, the second mixing is performed under heated conditions;
the heating temperature is 75-87 ℃.
Preferably, the third mixing process is as follows: and placing the oil phase in an oil phase tank, placing the water phase in a water phase tank, adding the oil phase into the water phase, backflushing the obtained material into the oil phase tank, conveying the obtained backflushed material into the water phase tank, and repeating the process of backflushing into the oil phase tank and conveying the material into the water phase tank.
Preferably, the temperature of the emulsification is 75-87 ℃ and the time is 25-35 min.
The invention also provides application of the lindane skin antibacterial paste in preparation of medicines for treating children parasite infection.
The invention provides a skin antibacterial paste containing woody denier, which comprises the following components in parts by mass: 3-5 parts of chlorhexidine acetate, 40-60 parts of permethrin, 90-110 parts of stearic acid, 72-88 parts of white vaseline, 57-71 parts of glyceryl monostearate, 9-11 parts of surfactant, 72-88 parts of glycerol, 0.9-1.1 parts of ethylparaben and 550-680 parts of water. The chlorhexidine acetate adopted in the lindane skin antibacterial paste is an external, efficient and safe antibacterial disinfectant, and can kill staphylococcus aureus, escherichia coli and candida albicans; the permethrin is safe and effective for children, has good tolerance and rapid metabolism, and can effectively reduce skin irritation. Meanwhile, the synergistic effect of other components helps to form a stable paste, so that the active ingredients are uniformly dispersed and easy to smear, the safe absorption of skin is facilitated, and the service life of the product is ensured.
Detailed Description
The invention provides a skin antibacterial paste containing woody denier, which comprises the following components in parts by mass: 3-5 parts of chlorhexidine acetate, 40-60 parts of permethrin, 90-110 parts of stearic acid, 72-88 parts of white vaseline, 57-71 parts of glyceryl monostearate, 9-11 parts of surfactant, 72-88 parts of glycerol, 0.9-1.1 parts of ethylparaben and 550-680 parts of water.
In the present invention, all the preparation materials are commercially available products well known to those skilled in the art unless specified otherwise.
The lindane skin antibacterial paste comprises 3-5 parts by weight of chlorhexidine acetate, preferably 3.8-4.2 parts by weight, and more preferably 4.0 parts by weight.
In the invention, the chlorhexidine acetate has the function of killing staphylococcus aureus, candida albicans and escherichia coli by 100 percent.
Based on the mass parts of the chlorhexidine acetate, the skin antibacterial cream comprises 40-60 parts of permethrin, preferably 48-52 parts, and more preferably 50 parts.
In the invention, the permethrin has the characteristics of broad spectrum, high efficiency, quick knockdown, long effect period and the like, and has the effect of killing parasites such as mites and scabies.
Based on the mass parts of the chlorhexidine acetate, the lindane skin antibacterial paste comprises 90-110 parts of stearic acid, preferably 95-105 parts of stearic acid, and more preferably 100 parts of stearic acid.
In the present invention, the stearic acid is a stabilizer having a combination of humidity, gloss and lubricity.
Based on the mass parts of the chlorhexidine acetate, the lindane skin antibacterial paste comprises 72-88 parts of white vaseline, preferably 76-83 parts, more preferably 78-81 parts and most preferably 80 parts.
In the present invention, the white petrolatum is used as a base and lubricant for ointments.
The lindane skin antibacterial cream comprises 57-71 parts of glycerin monostearate, preferably 60-68 parts, and more preferably 64-66 parts by weight of chlorhexidine acetate.
In the invention, the glyceryl monostearate is used as an emulsifying agent in the ointment, so that the ointment is fine and smooth.
The lindane skin antibacterial paste comprises 9-11 parts of surfactant, preferably 9.5-10.5 parts, and more preferably 10 parts, based on the mass parts of chlorhexidine acetate. In the present invention, the surfactant preferably includes sodium dodecyl sulfate and/or triethanolamine, more preferably includes sodium dodecyl sulfate; when the surfactant comprises sodium dodecyl sulfate and triethanolamine, the proportion of the sodium dodecyl sulfate and the triethanolamine is not limited in any particular way, and the mixture is mixed according to any proportion.
In the invention, the surfactant is used as an emulsifying agent, has stronger reducibility, can deactivate unstable proteins and enzymes, so that the product is kept in a more stable state, is preserved and fresh-keeping, and can emulsify lipid on the cell wall of pathogenic microorganisms, thereby playing a role in sterilization and disinfection.
Based on the mass parts of the chlorhexidine acetate, the lindane skin antibacterial paste comprises 72-88 parts of glycerin, preferably 76-82 parts, and more preferably 80 parts.
In the invention, the glycerol has the effects of moisturizing and lubricating, and can moisten skin.
Based on the mass parts of the chlorhexidine acetate, the lindane skin antibacterial paste comprises 0.9-1.1 parts of ethyl hydroxybenzoate, and preferably 1.0 parts.
In the present invention, the ethylparaben is used as a preservative and is also an antibacterial disinfectant.
Based on the mass parts of the chlorhexidine acetate, the lindane skin antibacterial paste comprises 550-680 parts of water, preferably 580-620 parts, and more preferably 611 parts. In the present invention, the water is preferably purified water.
The invention also provides a preparation method of the lindane skin antibacterial paste, which comprises the following steps:
mixing water, glycerol, surfactant, ethyl hydroxy benzoate and chlorhexidine acetate for the first time to obtain a water phase;
mixing stearic acid, glyceryl monostearate, white vaseline and permethrin to obtain oil phase;
and thirdly mixing the water phase and the oil phase, and emulsifying to obtain the lindane skin antibacterial paste.
The invention mixes water, glycerin, surfactant, ethyl hydroxy benzoate and chlorhexidine acetate to obtain water phase.
In the present invention, the first mixing preferably includes mixing water, glycerin, a surfactant, and ethyl hydroxy benzoate, and adding chlorhexidine acetate after heating. In the present invention, the heating temperature is preferably 75 to 87 ℃, more preferably 85±2 ℃. In the present invention, the addition of the chlorhexidine acetate is preferably performed under stirring; the stirring speed is preferably 300 to 600rpm, more preferably 350 to 550rpm, and most preferably 400 to 500rpm; the time is preferably 20 to 30 minutes, more preferably 22 to 28 minutes, and most preferably 24 to 26 minutes. In an embodiment of the present invention, the first mixing process specifically includes: mixing water, glycerol, sodium dodecyl sulfate and ethyl hydroxybenzoate, adding into a water phase preparation tank, heating to a target temperature, adding chlorhexidine acetate into the water phase preparation tank, stirring until all the chlorhexidine acetate is dissolved, and preserving heat to obtain the water phase.
The preparation method also comprises the step of secondarily mixing stearic acid, glyceryl monostearate, white vaseline and permethrin to obtain an oil phase.
In the present invention, the second mixing is preferably performed under heating; the heating temperature is preferably 75 to 87 ℃, more preferably 85±2 ℃. In the present invention, the second mixing is preferably performed under stirring, and the stirring process is not particularly limited, and may be performed by a process well known to those skilled in the art. In an embodiment of the present invention, the second mixing process specifically includes: adding stearic acid, glyceryl monostearate, white vaseline and permethrin into an oil phase preparation tank, heating to the second mixing temperature, stirring to dissolve completely, and maintaining the temperature to obtain the oil phase.
After the water phase and the oil phase are obtained, the water phase and the oil phase are mixed for the third time and emulsified to obtain the skin antibacterial paste.
In the present invention, the third mixing process is as follows: and placing the oil phase in an oil phase tank, placing the water phase in a water phase tank, adding the oil phase into the water phase, backflushing the obtained material into the oil phase tank, conveying the obtained backflushed material into the water phase tank, and repeating the process of backflushing into the oil phase tank and conveying the material into the water phase tank. In the present invention, the temperature of the aqueous phase during the third mixing is preferably the same as the temperature of the first mixing, and the temperature of the oil phase is preferably the same as the temperature of the second mixing. In the invention, the time for backflushing the obtained material into the oil phase tank is preferably 5min; the number of times of repeating the above-described process of back flushing to the oil phase tank and transporting to the water phase tank is preferably three times.
In the present invention, the temperature of the emulsification is preferably 75 to 87 ℃, more preferably 85±2 ℃; the time is preferably 25 to 35 minutes, more preferably 30 minutes.
After the emulsification is completed, the invention also preferably comprises cooling, wherein the cooling is preferably to 40+/-10 ℃ by adopting normal water through adding layers of a reaction tank.
The invention also provides application of the lindane skin antibacterial paste in preparation of medicines for treating children parasite infection. The method of the present invention is not particularly limited, and may be carried out by methods known to those skilled in the art.
The present invention provides a skin antibacterial paste for woody denier, a preparation method and application thereof, which are described in detail below with reference to examples, but they should not be construed as limiting the scope of the present invention.
Example 1
Adding 305.5kg of purified water, 40kg of glycerin, 5kg of sodium dodecyl sulfate and 0.5kg of ethylparaben into a water phase preparation tank, heating, and adding chlorhexidine acetate 2kg (according to C when water temperature reaches 85+ -2deg.C 26 H 38 Cl 2 N 10 O 4 Meter) adding the mixture into a water phase preparation tank, stirring for 30 minutes while adding (the stirring speed is 600 rpm) until the mixture is completely dissolved, and preserving heat for later use to obtain a water phase;
50kg of stearic acid, 32kg of glyceryl monostearate, 40kg of white vaseline and 25kg of permethrin are put into an oil phase preparation tank, heated, stirred until the temperature reaches 85+/-2 ℃, fully dissolved, and kept warm for standby to obtain an oil phase;
adding the oil phase at 85+/-2 ℃ into the water phase at 85+/-2 ℃, closing a conveying pump, opening a conveying valve of a water phase tank, backflushing materials in the water phase tank into the oil phase tank for 5 minutes, closing the conveying valve of the water phase tank, starting the conveying pump, adding backflushed materials into the water phase tank, repeating the operations for three times, starting emulsification timing, preserving heat at 85+/-2 ℃ for 30 minutes, cooling normal water to 40+/-10 ℃ through a layer adding of a reaction tank, and closing a cold water valve to obtain the Lindan skin antibacterial paste.
Example 2
Adding 611g of purified water, 40kg of glycerin, 80g of sodium dodecyl sulfate and 1g of ethylparaben into a water phase preparation tank, heating, and when the water temperature reaches 85+/-2 ℃, adding 4g of chlorhexidine acetate (according to C 26 H 38 Cl 2 N 10 O 4 Meter) adding the mixture into a water phase preparation tank, stirring for 30 minutes while adding (the stirring speed is 600 rpm) until the mixture is completely dissolved, and preserving heat for later use to obtain a water phase;
adding 100g of stearic acid, 64g of glyceryl monostearate, 80g of white vaseline and 50g of permethrin into an oil phase preparation tank, heating, stirring until the temperature reaches 85+/-2 ℃, and keeping the temperature for later use to obtain an oil phase;
adding the oil phase at 85+/-2 ℃ into the water phase at 85+/-2 ℃, closing a conveying pump, opening a conveying valve of a water phase tank, backflushing materials in the water phase tank into the oil phase tank for 5 minutes, closing the conveying valve of the water phase tank, starting the conveying pump, adding backflushed materials into the water phase tank, repeating the operations for three times, starting emulsification timing, preserving heat at 85+/-2 ℃ for 30 minutes, cooling normal water to 40+/-10 ℃ through a layer adding of a reaction tank, and closing a cold water valve to obtain the Lindan skin antibacterial paste.
Example 3
Adding 305.5kg of purified water, 40kg of glycerol, 5kg of sodium dodecyl sulfate and 0.5kg of ethylparaben into a water phase preparation tank, heating, and adding chlorhexidine acetate 2.4kg (according to C when the water temperature reaches 82+ -2deg.C 26 H 38 Cl 2 N 10 O 4 Meter) adding the mixture into a water phase preparation tank, stirring for 30 minutes while adding (the stirring speed is 600 rpm) until the mixture is completely dissolved, and preserving heat for later use to obtain a water phase;
50kg of stearic acid, 32kg of glyceryl monostearate, 40kg of white vaseline and 25kg of permethrin are put into an oil phase preparation tank, heated, stirred until the temperature reaches 82+/-2 ℃, fully dissolved, and kept warm for standby to obtain an oil phase;
adding the oil phase at 82+/-2 ℃ into the water phase at 82+/-2 ℃, closing a conveying pump, opening a conveying valve of a water phase tank, backflushing materials in the water phase tank into the oil phase tank for 5 minutes, closing the conveying valve of the water phase tank, starting the conveying pump, adding backflushed materials into the water phase tank, repeating the operations for three times, starting emulsification timing, preserving heat at 82+/-2 ℃ for 30 minutes, cooling normal water to 40+/-10 ℃ through a layer adding of a reaction tank, and closing a cold water valve to obtain the Lindan skin antibacterial paste.
Example 4
Adding 307.5kg of purified water, 40kg of glycerin, 5kg of sodium dodecyl sulfate and 0.5kg of ethylparaben into a water phase preparation tank, heating, and adding 2kg of chlorhexidine acetate (according to C when the water temperature reaches 80+ -2deg.C 26 H 38 Cl 2 N 10 O 4 Meter) adding the mixture into a water phase preparation tank, stirring for 30 minutes while adding (the stirring speed is 600 rpm) until the mixture is completely dissolved, and preserving heat for later use to obtain a water phase;
adding 50kg of stearic acid, 30kg of glyceryl monostearate, 40kg of white vaseline and 25kg of permethrin into an oil phase preparation tank, heating, stirring until the temperature reaches 80+/-2 ℃, and keeping the temperature for later use to obtain an oil phase;
adding the oil phase at 80+/-2 ℃ into the water phase at 80+/-2 ℃, closing a conveying pump, opening a conveying valve of a water phase tank, backflushing materials in the water phase tank into the oil phase tank for 5 minutes, closing the conveying valve of the water phase tank, starting the conveying pump, adding backflushed materials into the water phase tank, repeating the operations for three times, starting emulsification timing, preserving heat at 80+/-2 ℃ for 30 minutes, cooling normal water to 40+/-10 ℃ through a layer adding of a reaction tank, and closing a cold water valve to obtain the Lindan skin antibacterial paste.
Test case
Test object: the skin antibacterial cream of example 3;
test strain: coli (8099, both supplied by the academy of medical sciences) 7 th to 8 th generation; staphylococcus aureus; candida albicans;
test equipment: a graduated pipette, an electric mixer, a micropipette, a 37℃incubator;
neutralizing agent: PBS containing 1.0% sodium thiosulfate, 1.0% glycine, 1.0% lecithin and 3.0% Tween-80;
eluent: PBS 0.03 mol/L;
culture medium: tryptone soy agar medium (TSA);
the test basis is as follows: test according to the disinfection technical Specification (2002 edition) 2.1.11.3;
sterilization performance test: the sample is stock solution (chlorhexidine acetate content is 4850 mg/L), the action time is 2min, 5min, 10min and 20min, the test temperature is 20+ -1deg.C, and the test is repeated for 3 times;
the test results are shown in tables 1 to 3;
TABLE 1 sterilizing Effect of Lindan skin antibacterial paste on E.coli
Note that: negative control sterile growth
As can be seen from Table 1, the average 2-min sterilization rate of the three sterilization tests of the skin antibacterial paste of example 3 on Escherichia coli is 100%, the 5-min sterilization rate is 100%, the 10-min sterilization rate is 100%, and the 20-min sterilization rate is 100%, which meets the requirements of the "sterilization technical Specification" (2002 edition);
TABLE 2 sterilizing Effect of Lindan skin antibacterial paste on Staphylococcus aureus
Note that: negative control sterile growth
As can be seen from Table 2, the average 2-min sterilization rate of the three sterilization tests of the skin antibacterial paste of example 3 on staphylococcus aureus is 100%, the 5-min sterilization rate is 100%, the 10-min sterilization rate is 100%, and the 20-min sterilization rate is 100%, which meets the requirements of the "sterilization technical Specification" (2002 edition);
TABLE 3 sterilizing Effect of Lindan skin antibacterial paste on Candida albicans
Note that: negative control sterile growth
As shown in Table 3, the average 2-min sterilization rate of the three sterilization tests of the skin antibacterial paste of the embodiment 3 on candida albicans is 100%, the 5-min sterilization rate is 100%, the 10-min sterilization rate is 100%, and the 20-min sterilization rate is 100%, which meets the requirements of the "sterilization technical Specification" (2002 edition).
The lindane skin antibacterial cream described in example 3 was subjected to multiple complete skin irritation tests: the test result shows that the reaction score of the Lindan skin antibacterial paste in the embodiment 3 on a plurality of complete skin alkenyl tests of rabbits is 0, and the Lindan skin antibacterial paste belongs to no irritation;
the skin antibacterial paste of the lindane of the example 3 is respectively subjected to active ingredient content measurement, stability measurement, mercury content measurement, lead content measurement and arsenic content measurement;
and (3) measuring the content of active ingredients: the Lindan skin antibacterial paste in the embodiment 3 accords with the requirements of skin disinfectant health requirements GB27951-2011 through high performance liquid chromatography detection;
stability determination: after the lindane skin antibacterial paste described in example 3 is placed in a constant temperature incubator at 54 ℃ and stored for 14d, the average value of the content of the main active ingredient chlorhexidine acetate detected by a high performance liquid chromatography is 0.470wt%, and compared with the content before the storage, the drop rate of the active ingredient is 3.1%, the test result meets the requirements of the disinfection technical Specification (2002 edition), and the storage effective period of the product can be determined to be 2 years;
mercury content determination: the average value of the total mercury content of the skin antibacterial paste in the embodiment 3 is 0.003mg/kg, which meets the requirements of skin disinfectant health requirements GB 27951-2011;
and (3) lead content determination: the average value of the lead content of the lindane skin antibacterial paste in the embodiment 3 is less than 3.8mg/kg, which accords with the requirements of skin disinfectant health requirements GB 27951-2011;
and (3) arsenic content determination: as detected by a cyanide atomic fluorescence spectrophotometry, the average value of the total arsenic content of the skin antibacterial paste in the embodiment 3 is less than 0.02mg/kg, and meets the requirements of skin disinfectant health requirements GB 27951-2011.
The skin antibacterial pastes of examples 1 to 3 and 4 were subjected to the above performance test, and the test results were similar to those of example 3.
The foregoing is merely a preferred embodiment of the present invention and it should be noted that modifications and adaptations to those skilled in the art may be made without departing from the principles of the present invention, which are intended to be comprehended within the scope of the present invention.
Claims (10)
1. The skin antibacterial paste is characterized by comprising the following components in parts by mass: 3-5 parts of chlorhexidine acetate, 40-60 parts of permethrin, 90-110 parts of stearic acid, 72-88 parts of white vaseline, 57-71 parts of glyceryl monostearate, 9-11 parts of surfactant, 72-88 parts of glycerol, 0.9-1.1 parts of ethylparaben and 550-680 parts of water.
2. The lindane skin antibacterial cream of claim 1, wherein the surfactant comprises sodium dodecyl sulfate and/or triethanolamine.
3. The lindane skin antibacterial cream of claim 1 or 2, comprising the following components: 4 parts of chlorhexidine acetate, 50 parts of permethrin, 100 parts of stearic acid, 80 parts of white vaseline, 64 parts of glyceryl monostearate, 10 parts of a surfactant, 80 parts of glycerin, 1 part of ethylparaben and 611 parts of water.
4. A method for preparing the skin antibacterial cream of any one of claims 1 to 3, comprising the steps of:
mixing water, glycerol, surfactant, ethyl hydroxy benzoate and chlorhexidine acetate for the first time to obtain a water phase;
mixing stearic acid, glyceryl monostearate, white vaseline and permethrin to obtain oil phase;
and thirdly mixing the water phase and the oil phase, and emulsifying to obtain the lindane skin antibacterial paste.
5. The method of claim 4, wherein the first mixing comprises mixing water, glycerol, a surfactant, and ethyl hydroxy benzoate, heating, and adding chlorhexidine acetate.
6. The method of claim 5, wherein the heating is at a temperature of 75 to 87 ℃;
adding the chlorhexidine acetate under stirring; the stirring speed is 300-600 rpm, and the stirring time is 20-30 min.
7. The method of claim 4, wherein the second mixing is performed under heated conditions;
the heating temperature is 75-87 ℃.
8. The method of claim 4, wherein the third mixing is performed by: and placing the oil phase in an oil phase tank, placing the water phase in a water phase tank, adding the oil phase into the water phase, backflushing the obtained material into the oil phase tank, conveying the obtained backflushed material into the water phase tank, and repeating the process of backflushing into the oil phase tank and conveying the material into the water phase tank.
9. The method according to claim 4, wherein the emulsification is carried out at a temperature of 75 to 87℃for a period of 25 to 35 minutes.
10. Use of the skin antibacterial cream of lindane according to any one of claims 1 to 3 or the skin antibacterial cream of lindane according to any one of claims 4 to 9 in the preparation of a medicament for treating parasitic infection in children.
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