CN106173802A - A kind of NEW TYPE OF COMPOSITE Midew preventive for feed and its preparation method and application - Google Patents
A kind of NEW TYPE OF COMPOSITE Midew preventive for feed and its preparation method and application Download PDFInfo
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- CN106173802A CN106173802A CN201610539441.8A CN201610539441A CN106173802A CN 106173802 A CN106173802 A CN 106173802A CN 201610539441 A CN201610539441 A CN 201610539441A CN 106173802 A CN106173802 A CN 106173802A
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
- A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
- A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
- A23L3/3463—Organic compounds; Microorganisms; Enzymes
- A23L3/3481—Organic compounds containing oxygen
- A23L3/3499—Organic compounds containing oxygen with doubly-bound oxygen
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
- A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
- A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
- A23L3/3463—Organic compounds; Microorganisms; Enzymes
- A23L3/3535—Organic compounds containing sulfur
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Abstract
The invention belongs to feed additive field, be specifically related to a kind of NEW TYPE OF COMPOSITE Midew preventive for feed and its preparation method and application, this mixed feed antifungus agent active component is made up of cinnamic aldehyde, citral, allyl isosulfocyanate.NEW TYPE OF COMPOSITE Midew preventive for feed of the present invention, the most safe and nontoxic, play bacteria mildew-proof effect, and also additive capacity is little, cost-effective, and palatability can be improved, improve the production performance of animal, improve the immunity of animal, it is adaptable to the mildew-resistant of all feeds such as mixed feed, concentrate feed, premix material.
Description
Technical field
The present invention relates to a kind of feed additive, be specifically related to NEW TYPE OF COMPOSITE Midew preventive for feed and preparation method thereof and answer
With, belong to field of feed additive technology.
Background technology
China is the second in the world Feed Manufacturing state, and annual forage yield is increasing trend.Continuous increasing along with forage yield
Adding, the storage problem of feedstuff becomes one of key link of relation feed quality.In storage, owing to feedstuff is highly prone to
Mould contamination, this brings loss greatly, annual loss even as high as up to ten million tons to China's feed industry.So, how to solve
Certainly feed mold becomes one of problem demanding prompt solution.Add Midew preventive for feed and be to ensure that an important solution way of feed quality
Footpath.At present, antifungus agent on the market is mainly organic acid and its esters, although this antifungus agent is cheap and plays mildew-resistant
Effect, but there is also deficiency: (1) tradition antifungus agent large usage quantity, such as the feedstuff mildew mentioned in patent CN 102308905B
Agent, its organic acid content accounts for 40-60%, large usage quantity, the most not only can reduce the content of nutrient substance, and possible increase is right
The corrosivity of equipment；(2) tradition antifungus agent mainly includes machine acid and its esters, as anti-in mention in patent CN93118854.7
Mould dose, containing the multiple organic acid such as sodium diacetate, benzoic acid and its esters, although there is broad-spectrum antibacterial, but it has stimulation
Property abnormal smells from the patient, may affect the palatability of animal, thus affect the feed intake of animal.
Summary of the invention
The deficiency existed for above prior art, the present invention provides a kind of with cinnamic aldehyde, citral, isothiocyanic acid allyl
The safe and efficient stable NEW TYPE OF COMPOSITE that ester is that the consumption of main component is little, can improve animal palatability and good antimicrobial effect is raised
Material antifungus agent.
The present invention provides the first NEW TYPE OF COMPOSITE Midew preventive for feed, and its active component is made up of cinnamic aldehyde and citral.
Preferably, the weight ratio of its active component cinnamic aldehyde and citral is 0.5-10: 0.5-10；More preferably 1-
6∶1-6；Further it is preferably 1: 1.
The present invention studies discovery, there is therebetween significantly association as cinnamic aldehyde during mixed feed antifungus agent and citral
Same synergy.
Especially, the present invention studies discovery, as cinnamic aldehyde, citral and isothiocyanic acid allyl during mixed feed antifungus agent
Significantly more syneryistic effect is there is between ester three.Thus, the present invention also provides for the second NEW TYPE OF COMPOSITE feedstuff mildew
Agent, increases active component allyl isosulfocyanate in the first antifungus agent above-mentioned, and i.e. its active component is by cinnamic aldehyde, citral
Form with allyl isosulfocyanate.
Above-mentioned the second NEW TYPE OF COMPOSITE Midew preventive for feed, the preferably weight ratio of its active component cinnamic aldehyde and citral are
0.5-10∶0.5-10；More preferably 1-6: 1-6；Further it is preferably 1: 1；Wherein its active component cinnamic aldehyde preferred
It it is 5-40 times of active component allyl isosulfocyanate weight with the gross weight of citral；More preferably 10-20 times；More enter
Preferably, the weight ratio of its active component cinnamic aldehyde, citral and allyl isosulfocyanate is 8: 8: 1 to one step.
Further, research finds to assist when said ratio scope compounds when cinnamic aldehyde, citral, allyl isosulfocyanate
More prominent with synergy.
NEW TYPE OF COMPOSITE Midew preventive for feed of the present invention (the first and the second) also includes the carrier that field of fodder allows,
Various common dosage forms can be prepared as.
Described carrier includes any one in white carbon, porous-starch, calcium carbonate, feeding zeolite powder, Semen Maydis powder etc. or several
The compositions planted；Described carrier is preferably white carbon.Owing to this carrier white carbon surface area is big, the beneficially absorption of effective ingredient.
The present invention above-mentioned NEW TYPE OF COMPOSITE Midew preventive for feed, wherein said active component is at described NEW TYPE OF COMPOSITE Midew preventive for feed
In weight/mass percentage composition be preferably 5%-50%；More preferably 10%-30%.
Preferably, the present invention above-mentioned NEW TYPE OF COMPOSITE Midew preventive for feed is the dosage forms such as microcapsule, powder, pellet.
It is highly preferred that NEW TYPE OF COMPOSITE Midew preventive for feed of the present invention (the first and the second) is microcapsule；Experiment card
When the bright present invention above-mentioned NEW TYPE OF COMPOSITE Midew preventive for feed is microcapsule, relatively general formulation has more preferably anti-mold effect.
Carrier or the adjuvant of described microcapsule include one or more in porous-starch, alginate etc..
Specifically, the present invention the first NEW TYPE OF COMPOSITE Midew preventive for feed above-mentioned is microcapsule, includes following in parts by weight
The component of weight portion: cinnamic aldehyde 5-30 part, citral 5-30 part, or still further comprise carrier, described carrier is that porous is formed sediment
Powder or white carbon, the weight of described carrier is 0.5-2 times of described active component weight；
Preferably, including the component of lower weight portion: cinnamic aldehyde 8-20 part, citral 8-20 part, or still further comprise
Carrier, described carrier is porous-starch or white carbon, and the weight of described carrier is 1 times of described active component weight.
Specifically, the present invention above-mentioned the second NEW TYPE OF COMPOSITE Midew preventive for feed is microcapsule, includes following in parts by weight
The component of weight portion: cinnamic aldehyde 5-30 part, citral 5-30 part, allyl isosulfocyanate 0.5-3 part, or still further comprise
Carrier, described carrier is porous-starch or white carbon, and the weight of described carrier is 0.5-2 times of described active component weight；
Preferably, including the component of lower weight portion: cinnamic aldehyde 8-20 part, citral 8-20 part, allyl isosulfocyanate 1-2
Part, or still further comprising carrier, described carrier is porous-starch or white carbon, and the weight of described carrier is that described activity becomes
Divide weight 1 times.
Cinnamic aldehyde of the present invention, citral and allyl isosulfocyanate can be all to extract from plant, it would however also be possible to employ
It is chemically synthesized；Or it is obtained from commercially available.
Weight portion of the present invention or part can be the unit of weights well known in the art such as μ g, mg, g, kg, it is also possible to be it
Multiple, such as 1/10,1/100,10 times, 100 times etc..
The present invention also provides for the preparation method of above-mentioned NEW TYPE OF COMPOSITE Midew preventive for feed, can prepare by existing conventional method.
Preferably, the preparation method of above-mentioned NEW TYPE OF COMPOSITE Midew preventive for feed, weigh active component (Cortex Cinnamomi including by formula
Aldehyde, citral, allyl isosulfocyanate), after stirring and evenly mixing, or join further in carrier, fully mix, to obtain final product.
It is further preferred that the preparation method of above-mentioned NEW TYPE OF COMPOSITE Midew preventive for feed, take activity one-tenth including weighing by formula
Dividing (cinnamic aldehyde, citral, allyl isosulfocyanate), emulsifying is prepared as microcapsule, is coated, and to obtain final product.
Specifically, the preparation method of above-mentioned microcapsule NEW TYPE OF COMPOSITE Midew preventive for feed comprises the steps:
By active component (cinnamic aldehyde and citral；Or cinnamic aldehyde, citral and allyl isosulfocyanate) and Tween 80
Mixing, is prepared as emulsion, is subsequently adding in 1.5-3.5% sodium alginate aqueous solution (referring to mass concentration), dispersed with stirring, dropping
Or it is sprayed to solidification 30-120 minute in the calcium chloride water (referring to mass concentration) of 1-3%, filter, normal temperature drying, can make
Obtain microcapsule.
Preferably, the consumption of Tween 80 is described active component (cinnamic aldehyde and citral；Or cinnamic aldehyde, citral and
Allyl isosulfocyanate) 0.05-0.1% of weight.
Or the preparation method of above-mentioned microcapsule NEW TYPE OF COMPOSITE Midew preventive for feed comprises the steps:
By active component (cinnamic aldehyde and citral；Or cinnamic aldehyde, citral and allyl isosulfocyanate) (many with carrier
Hole starch or white carbon) mixing, it is subsequently adding in 1.5-3.5% sodium alginate aqueous solution (referring to mass concentration), dispersed with stirring, drips
Add or be sprayed to solidification 30-12 minute in the calcium chloride water (referring to mass concentration) of 1-3%, filter, normal temperature drying, can make
Obtain microcapsule.
Encapsulated form, compared with conventional dosage forms, has following advantage: 1, owing to the effective ingredient such as cinnamic aldehyde, citral is easy
Volatilization, general dosage form is unfavorable for that it preserves, and encapsulated form can extend its pot-life；2, encapsulated form can improve Cortex Cinnamomi
The effective ingredient such as aldehyde, citral utilization rate in animal body；3, encapsulated form can discharge effective ingredient when specifying.
Present invention additionally comprises the animal feed containing above-mentioned NEW TYPE OF COMPOSITE Midew preventive for feed.
Present invention additionally comprises the application in preparing animal feed of the above-mentioned NEW TYPE OF COMPOSITE Midew preventive for feed.
Advise that the NEW TYPE OF COMPOSITE Midew preventive for feed of the present invention addition in animal feed is 20-200mg/kg, excellent
Elect 80mg/kg as；It is particularly well-suited to the animal and fowl fodder such as complete feedstuff, premix material.
NEW TYPE OF COMPOSITE Midew preventive for feed of the present invention especially has significant anti-mold effect to Aspergillus flavus etc..
Compared to existing technology, the most progressive effect of the present invention is:
(1) present invention raw materials used to animal without any harm, do not have any residual, the minimal inhibitory concentration of product is
80ppm, consumption is little, thus reduces feed cost.
(2) antifungus agent that the present invention relates to is mainly used in adding to feedstuff, compensate for the deficiency of tradition antifungus agent, and has
Research shows, in the present invention, the composition of antifungus agent can improve the production performance of animal, improves immunity, improves the utilization of feedstuff
Rate.
(3) this product preparation process is simple, easily prepares.
(4) there is good antibacterial action, the palatability of animal can be improved.
Detailed description of the invention
Following example are used for illustrating the present invention, but are not limited to the scope of the present invention.In embodiment unreceipted specifically
Technology or condition person, according to the technology described by the document in this area or condition, or carried out according to product description.Used
Reagent or instrument unreceipted production firm person, be the conventional products can being commercially available by regular distributor.Wherein, Cortex Cinnamomi
Aldehyde, citral and allyl isosulfocyanate are respectively purchased from commercially available prod, and its content is all more than 90%.
Embodiment 1
A kind of NEW TYPE OF COMPOSITE Midew preventive for feed, contains following active component in parts by weight: cinnamic aldehyde 8 parts, citral 8
Part, possibly together with carrier white carbon 20 parts.
The present embodiment also provides for the preparation method of this NEW TYPE OF COMPOSITE Midew preventive for feed, including weighing activity one-tenth respectively by formula
Divide (cinnamic aldehyde, citral), after the two stirring and evenly mixing, join in white carbon, fully mix, to obtain final product.
Embodiment 2
A kind of NEW TYPE OF COMPOSITE Midew preventive for feed, contains following active component in parts by weight: cinnamic aldehyde 5 parts, citral 30
Part, possibly together with carrier white carbon 55 parts.
The preparation method of the present embodiment NEW TYPE OF COMPOSITE Midew preventive for feed is with embodiment 1.
Embodiment 3
A kind of NEW TYPE OF COMPOSITE Midew preventive for feed, contains following active component in parts by weight: cinnamic aldehyde 5 parts, citral 10
Part, possibly together with carrier white carbon 30 parts.
The preparation method of the present embodiment NEW TYPE OF COMPOSITE Midew preventive for feed is with embodiment 1.
Embodiment 4
A kind of NEW TYPE OF COMPOSITE Midew preventive for feed, contains following active component in parts by weight: cinnamic aldehyde 30 parts, citral 5
Part, possibly together with carrier white carbon 55 parts.
The preparation method of the present embodiment NEW TYPE OF COMPOSITE Midew preventive for feed is with embodiment 1.
Embodiment 5
A kind of NEW TYPE OF COMPOSITE Midew preventive for feed, contains following active component in parts by weight: cinnamic aldehyde 15 parts, citral 5
Part, possibly together with carrier white carbon 40 parts.
The preparation method of the present embodiment NEW TYPE OF COMPOSITE Midew preventive for feed is with embodiment 1.
Embodiment 6
A kind of NEW TYPE OF COMPOSITE Midew preventive for feed, contains following active component in parts by weight: cinnamic aldehyde 20 parts, citral 10
Part, possibly together with carrier white carbon 60 parts.
The preparation method of the present embodiment NEW TYPE OF COMPOSITE Midew preventive for feed is with embodiment 1.
Embodiment 7-12
A kind of NEW TYPE OF COMPOSITE Midew preventive for feed, for encapsulated form, its active component proportioning is identical with embodiment 1-6 respectively,
Difference is carrier white carbon is replaced with porous-starch.
The present embodiment also provides for the preparation method of this NEW TYPE OF COMPOSITE Midew preventive for feed, weighs active component including by formula
(cinnamic aldehyde, citral) and carrier (porous-starch), emulsifying is prepared as microcapsule, is coated, and to obtain final product.
Embodiment 13
A kind of NEW TYPE OF COMPOSITE Midew preventive for feed, contains following active component in parts by weight: cinnamic aldehyde 8 parts, citral 8
Part, allyl isosulfocyanate 1 part, possibly together with carrier white carbon 20 parts.
The present embodiment also provides for the preparation method of this NEW TYPE OF COMPOSITE Midew preventive for feed, including weighing activity one-tenth respectively by formula
Divide (cinnamic aldehyde, citral allyl isosulfocyanate), after three's stirring and evenly mixing, join in white carbon, fully mix, i.e.
?.
Embodiment 14
A kind of NEW TYPE OF COMPOSITE Midew preventive for feed, contains following active component in parts by weight: cinnamic aldehyde 5 parts, citral 30
Part, allyl isosulfocyanate 3.5 parts, possibly together with carrier white carbon 55 parts.
The preparation method of the present embodiment NEW TYPE OF COMPOSITE Midew preventive for feed is with embodiment 13.
Embodiment 15
A kind of NEW TYPE OF COMPOSITE Midew preventive for feed, contains following active component in parts by weight: cinnamic aldehyde 5 parts, citral 10
Part, allyl isosulfocyanate 1 part, possibly together with carrier white carbon 20 parts.
The preparation method of the present embodiment NEW TYPE OF COMPOSITE Midew preventive for feed is with embodiment 13.
Embodiment 16
A kind of NEW TYPE OF COMPOSITE Midew preventive for feed, contains following active component in parts by weight: cinnamic aldehyde 30 parts, citral 5
Part, allyl isosulfocyanate 7 parts, possibly together with carrier white carbon 55 parts.
The preparation method of the present embodiment NEW TYPE OF COMPOSITE Midew preventive for feed is with embodiment 13.
Embodiment 17
A kind of NEW TYPE OF COMPOSITE Midew preventive for feed, contains following active component in parts by weight: cinnamic aldehyde 15 parts, citral 5
Part, allyl isosulfocyanate 2.5 parts, possibly together with carrier white carbon 30 parts.
The preparation method of the present embodiment NEW TYPE OF COMPOSITE Midew preventive for feed is with embodiment 13.
Embodiment 18
A kind of NEW TYPE OF COMPOSITE Midew preventive for feed, contains following active component in parts by weight: cinnamic aldehyde 20 parts, citral 10
Part, allyl isosulfocyanate 5 parts, possibly together with carrier white carbon 60 parts.
The preparation method of the present embodiment NEW TYPE OF COMPOSITE Midew preventive for feed is with embodiment 13.
Embodiment 19
A kind of NEW TYPE OF COMPOSITE Midew preventive for feed, contains following active component in parts by weight: cinnamic aldehyde 5 parts, citral 30
Part, allyl isosulfocyanate 1.5 parts, possibly together with carrier white carbon 55 parts.
The preparation method of the present embodiment NEW TYPE OF COMPOSITE Midew preventive for feed is with embodiment 13.
Embodiment 20
A kind of NEW TYPE OF COMPOSITE Midew preventive for feed, contains following active component in parts by weight: cinnamic aldehyde 30 parts, citral 5
Part, allyl isosulfocyanate 0.5 part, possibly together with carrier white carbon 55 parts.
The preparation method of the present embodiment NEW TYPE OF COMPOSITE Midew preventive for feed is with embodiment 13.
Embodiment 21-28
A kind of NEW TYPE OF COMPOSITE Midew preventive for feed, its active component proportioning is identical with embodiment 13-20 respectively, difference be for
Encapsulated form.
The present embodiment also provides for the preparation method of this NEW TYPE OF COMPOSITE Midew preventive for feed, weighs active component including by formula
(cinnamic aldehyde, citral, allyl isosulfocyanate) and carrier (white carbon), mix homogeneously is subsequently adding mass concentration 2.5% sea
In sodium alginate aqueous solution, dispersed with stirring, it is added drop-wise in the calcium chloride water of mass concentration 1.5% solidification 60 minutes, filters, often
Temperature is dried,.
Experimental example 1
Anti-mold effect is investigated by following experimental technique.
1, experiment packet:
Laboratory sample 1-1: cinnamic aldehyde, both citrals are with the mixture of weight ratio 1:1；
Laboratory sample 1-2: cinnamic aldehyde, both citrals are with the mixture of weight ratio 1:6；
Laboratory sample 1-3: cinnamic aldehyde, both citrals are with the mixture of weight ratio 1:20；
Laboratory sample 1-4: cinnamic aldehyde, both citrals are with the mixture of weight ratio 6:1；
Laboratory sample 1-5: cinnamic aldehyde, both citrals are with the mixture of weight ratio 20:1；
Laboratory sample 2-1: cinnamic aldehyde, citral, allyl isosulfocyanate three are with the mixture of weight ratio 8:8:1；
Laboratory sample 2-2: cinnamic aldehyde, citral, allyl isosulfocyanate three are with the mixture of weight ratio 1:6:0.7；
Laboratory sample 2-3: cinnamic aldehyde, citral, allyl isosulfocyanate three are with the mixture of weight ratio 1:20:1；
Laboratory sample 2-4: cinnamic aldehyde, citral, allyl isosulfocyanate three are with the mixture of weight ratio 6:1:1.4；
Laboratory sample 2-5: cinnamic aldehyde, citral, allyl isosulfocyanate three are with the mixture of weight ratio 20:1:0.5；
Control sample 1: cinnamic aldehyde；
Control sample 2: citral；
Control sample 3: allyl isosulfocyanate；
Control sample 4: cinnamic aldehyde, both allyl isosulfocyanates are with the mixture of weight ratio 1:1；
Control sample 5: citral, both allyl isosulfocyanates are with the mixture of weight ratio 1:1；
Control sample 6: certain commercially available antifungus agent (being mainly composed of propanoic acid)；
Control sample 7: certain commercially available antifungus agent (being mainly composed of formic acid).
2, experimental technique:
Feeds utilized from commercially available laying-hen compound feed, it is crushed to 40 mesh.First by Aspergillus flavus Asp1
The spore of (Aspergillus flavus) is linked in above-mentioned laying-hen compound feed (after inoculation in feedstuff according to the ratio of 5%
The spore amount of Aspergillus flavus is 105CFU/g), then by above laboratory sample and control sample it is respectively connected to above-mentioned mixed feed
In, 28 DEG C, cultivate under the damp condition of 60%.Be added without any antifungus agent above-mentioned mixed feed as blank.Investigate
Fungicidal properties.
3, experimental result: see table 1-1.
Table 1-1 fungicidal properties result
Remarks :-represent and go mouldy, i.e. feed surface and inside are all without any mycelial growth；
± represent and slightly go mouldy, and only grow a small amount of mycelia on feedstuff top layer；
+ represent that moderate is gone mouldy, and only grow a large amount of mycelia on feedstuff top layer, but have no inside feedstuff；
++ represent that severe is gone mouldy, inside feedstuff top layer and feedstuff, grow a large amount of mycelia.
Ppm refers to the active component of each laboratory sample and control sample addition in above-mentioned mixed feed.
Table 1-1 result shows: compare with single dose, and after cinnamic aldehyde, both citrals are compounding, the fungicidal properties to Aspergillus flavus has
Significant increase, obvious synergy；(when mixed feed antifungus agent active component is made up of cinnamic aldehyde and citral
Time, the two part by weight is that 1: 1 anti-mold effect is optimal)
After cinnamic aldehyde, citral, allyl isosulfocyanate three are compounding to the fungicidal properties of Aspergillus flavus more preferably, three works in coordination with
Potentiation notable (when mixed feed antifungus agent active component is made up of cinnamic aldehyde, citral and allyl isosulfocyanate, three
Person's part by weight is that 8: 8: 1 anti-mold effects are optimal).
Result shows: the Compositional antiseptic agent that the present invention provides has synergy, and is better than prior art.
Experimental example 2
Following laboratory sample is utilized to measure its fungicidal properties.
1, experiment packet:
Laboratory sample: embodiment 13-20 NEW TYPE OF COMPOSITE Midew preventive for feed (powder) and embodiment 21-28 NEW TYPE OF COMPOSITE feedstuff
Antifungus agent (encapsulated form)；
2, experimental technique:
With experimental example 1.Often group antifungus agent active component dosage used is homogeneously same, is 80ppm, but often organizes ratio used not
With.It is specifically shown in above-described embodiment.
3, experimental result: see table 2-1.
Table 2-1 fungicidal properties result
Remarks :-represent and go mouldy, i.e. feed surface and inside are all without any mycelial growth；
± represent and slightly go mouldy, and only grow a small amount of mycelia on feedstuff top layer；
+ represent that moderate is gone mouldy, and only grow a large amount of mycelia on feedstuff top layer, but have no inside feedstuff；
++ represent that severe is gone mouldy, inside feedstuff top layer and feedstuff, grow a large amount of mycelia.
Ppm refers to each sample addition in above-mentioned mixed feed.
Experimental example 3
Antifungus agent in the present invention is carried out the contrast test of animal.Selecting 270 AA broiler of 1 age in days is experimental animal pair
As, it being randomly divided into three groups, often three repetitions of group, each repetition 30, I group is blank group, feeding basal diet (without
Antifungus agent), daily ration+0.1% antifungus agent based on II, III group of difference, basal diet+0.2% antifungus agent, antifungus agent is embodiment
The composite mildew inhibitor of 13, the test period is 42 days, and test chicken respectively repeats to use sub-cage rearing, free choice feeding and drinking-water.Light in house
Require to carry out according to conventional feeding and management according to, humidity and temperature etc..Result of the test shows (see table 3-1 and 3-2), process group II
With III average daily gain significantly improve, and feedstuff-meat ratio reduce, meanwhile, process group is compared with matched group, and index of immunity substantially carries
Height, so, use the antifungus agent in the present invention can improve the production performance of animal, improve efficiency of feed utilization, improve animal
Immune function.
The impact on meat chicken production performance of the table 3-1 antifungus agent
Table 3-2 antifungus agent is on broiler index and spleen index and the impact of bursal index
Although, the present invention is described in detail the most with a general description of the specific embodiments, but
On the basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Cause
This, these modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to the scope of protection of present invention.
Claims (10)
1. a NEW TYPE OF COMPOSITE Midew preventive for feed, it is characterised in that its active component is made up of cinnamic aldehyde and citral；Or its
Active component is made up of cinnamic aldehyde, citral and allyl isosulfocyanate.
NEW TYPE OF COMPOSITE Midew preventive for feed the most according to claim 1, it is characterised in that its active component cinnamic aldehyde and Fructus Citri Limoniae
The weight ratio of aldehyde is 0.5-10: 0.5-10；It is preferably 1-6: 1-6；More preferably 1: 1.
3. according to the NEW TYPE OF COMPOSITE Midew preventive for feed described in any one of claim 1 or 2, it is characterised in that its active component meat
The gross weight of cinnamic aldehyde and citral is 5-40 times of allyl isosulfocyanate weight；It is preferably 10-20 times；It is further preferred that
The weight ratio of its active component cinnamic aldehyde, citral and allyl isosulfocyanate is 8: 8: 1.
4. according to the NEW TYPE OF COMPOSITE Midew preventive for feed described in any one of claim 1-3, it is characterised in that also include field of fodder
The carrier allowed；Preferably, arbitrary during described carrier is white carbon, porous-starch, calcium carbonate, feeding zeolite powder, Semen Maydis powder
Kind or several compositionss.
NEW TYPE OF COMPOSITE Midew preventive for feed the most according to claim 4, it is characterised in that described active component is described novel
Weight/mass percentage composition in mixed feed antifungus agent is 5%-50%；It is preferably 10%-30%.
6. according to the arbitrary described NEW TYPE OF COMPOSITE Midew preventive for feed of claim 1-3, it is characterised in that it is microcapsule, with weight
Amount part meter includes the component of following weight portion: cinnamic aldehyde 5-30 part, citral 5-30 part, or still further comprises carrier, institute
Stating carrier is porous-starch or white carbon, and the weight of described carrier is 0.5-2 times of described active component weight；
Preferably, including the component of lower weight portion: cinnamic aldehyde 8-20 part, citral 8-20 part, or still further comprise carrier,
Described carrier is porous-starch or white carbon, and the weight of described carrier is 1 times of described active component weight.
7. according to the arbitrary described NEW TYPE OF COMPOSITE Midew preventive for feed of claim 1-3, it is characterised in that it is microcapsule, with weight
Amount part meter includes the component of following weight portion: cinnamic aldehyde 5-30 part, citral 5-30 part, allyl isosulfocyanate 0.5-3 part, or
Person still further comprises carrier, and described carrier is porous-starch or white carbon, and the weight of described carrier is described active component weight
0.5-2 times of amount；
Preferably, including the component of lower weight portion: cinnamic aldehyde 8-20 part, citral 8-20 part, allyl isosulfocyanate 1-2 part,
Or still further comprising carrier, described carrier is porous-starch or white carbon, and the weight of described carrier is described active component
1 times of weight.
8. the preparation method of novel fodder antifungus agent described in claim 6 or 7, it is characterised in that described method includes described
Active component mixes with Tween 80, is prepared as emulsion, is subsequently adding in 1.5-3.5% sodium alginate aqueous solution, dispersed with stirring,
Drip or be sprayed to the calcium chloride water of 1-3% solidifies 30-120 minute, filter, normal temperature drying,；
Or described method includes mixing described active component with described carrier, is subsequently adding 1.5-3.5% sodium alginate water
In solution, dispersed with stirring, drip or be sprayed to the calcium chloride water of 1-3% solidifies 30-120 minute, filter, air setting
It is dry,.
9. NEW TYPE OF COMPOSITE Midew preventive for feed application in preparing animal feed described in any one of claim 1-7.
Application the most according to claim 9, it is characterised in that described NEW TYPE OF COMPOSITE Midew preventive for feed is in animal feed
Addition be 20-200mg/kg, preferably 80mg/kg.
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Application publication date: 20161207 |