CN117158433A - Preparation method of synergistic diniconazole mixed composition - Google Patents
Preparation method of synergistic diniconazole mixed composition Download PDFInfo
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- CN117158433A CN117158433A CN202210585968.XA CN202210585968A CN117158433A CN 117158433 A CN117158433 A CN 117158433A CN 202210585968 A CN202210585968 A CN 202210585968A CN 117158433 A CN117158433 A CN 117158433A
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- parts
- diniconazole
- synergistic
- preparation
- mixed composition
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- FBOUIAKEJMZPQG-BLXFFLACSA-N diniconazole-M Chemical compound C1=NC=NN1/C([C@H](O)C(C)(C)C)=C/C1=CC=C(Cl)C=C1Cl FBOUIAKEJMZPQG-BLXFFLACSA-N 0.000 title claims abstract description 49
- 239000000203 mixture Substances 0.000 title claims abstract description 46
- 230000002195 synergetic effect Effects 0.000 title claims abstract description 25
- 238000002360 preparation method Methods 0.000 title abstract description 17
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims abstract description 30
- 239000012752 auxiliary agent Substances 0.000 claims abstract description 26
- 239000003381 stabilizer Substances 0.000 claims abstract description 19
- 239000002562 thickening agent Substances 0.000 claims abstract description 19
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000011593 sulfur Substances 0.000 claims abstract description 16
- 229910052717 sulfur Inorganic materials 0.000 claims abstract description 16
- 229940009868 aluminum magnesium silicate Drugs 0.000 claims abstract description 15
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 claims abstract description 15
- 229910001629 magnesium chloride Inorganic materials 0.000 claims abstract description 15
- 238000003756 stirring Methods 0.000 claims description 18
- 239000013530 defoamer Substances 0.000 claims description 16
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 12
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 12
- 238000001914 filtration Methods 0.000 claims description 12
- 229930003427 Vitamin E Natural products 0.000 claims description 6
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 6
- 239000004495 emulsifiable concentrate Substances 0.000 claims description 6
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 229910000402 monopotassium phosphate Inorganic materials 0.000 claims description 6
- 235000019796 monopotassium phosphate Nutrition 0.000 claims description 6
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 claims description 6
- LWIHDJKSTIGBAC-UHFFFAOYSA-K potassium phosphate Substances [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 claims description 6
- 229910052710 silicon Inorganic materials 0.000 claims description 6
- 239000010703 silicon Substances 0.000 claims description 6
- 229940046009 vitamin E Drugs 0.000 claims description 6
- 235000019165 vitamin E Nutrition 0.000 claims description 6
- 239000011709 vitamin E Substances 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 5
- 230000000694 effects Effects 0.000 abstract description 6
- 230000001954 sterilising effect Effects 0.000 abstract description 5
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 5
- 230000008635 plant growth Effects 0.000 abstract description 4
- 239000002518 antifoaming agent Substances 0.000 abstract description 3
- 230000002265 prevention Effects 0.000 abstract description 3
- 239000003337 fertilizer Substances 0.000 abstract description 2
- 239000002994 raw material Substances 0.000 abstract description 2
- 239000002689 soil Substances 0.000 abstract description 2
- 230000000361 pesticidal effect Effects 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 239000003899 bactericide agent Substances 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 238000007086 side reaction Methods 0.000 description 2
- 241000233866 Fungi Species 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 229910052784 alkaline earth metal Chemical class 0.000 description 1
- 150000001342 alkaline earth metals Chemical class 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010520 demethylation reaction Methods 0.000 description 1
- 230000008029 eradication Effects 0.000 description 1
- 230000008686 ergosterol biosynthesis Effects 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- -1 inorganic acid salts Chemical class 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention provides a preparation method of a synergistic diniconazole mixed composition, and relates to the technical field of diniconazole mixed composition preparation. The preparation method of the synergistic diniconazole mixed composition comprises the following components in parts by weight: 10-40 parts of diniconazole, 20-30 parts of magnesium chloride, 20-30 parts of aluminum magnesium silicate, 1-4 parts of sulfur and 1-2 parts of auxiliary agents, wherein the auxiliary agents comprise a stabilizer, a synergist, a thickener and a defoaming agent. The magnesium chloride and the aluminum magnesium silicate are added into the diniconazole raw material to play a certain synergistic effect, so that organic elements in soil can be improved, a certain trace fertilizer effect is achieved while sterilization is performed, plant growth is facilitated, and the composition formed by diniconazole is synergistic by adding sulfur, so that the sterilization rate is improved, a certain deinsectization effect is achieved, plant growth is facilitated, the whole preparation is simple, prevention and control cost can be greatly reduced, and the obtained diniconazole mixed composition is high in pesticide effect and low in toxicity.
Description
Technical Field
The invention relates to the technical field of preparation of diniconazole mixed compositions, in particular to a preparation method of a synergistic diniconazole mixed composition.
Background
Diniconazole, also known as fast-acting, is triazole bactericide, is broad-spectrum bactericide with protection, treatment and eradication effects, and can inhibit 14 alpha-demethylation in ergosterol biosynthesis of fungi, and act on fungal cell membranes, thereby playing a role in sterilization.
On the basis of maintaining the active structure of diniconazole, the researchers try to convert the diniconazole into derivatives by utilizing the chemical property of diniconazole so as to achieve the purposes of improving the activity and reducing the cost. Patent literature reports that the efficacy of diniconazole and inorganic acid is improved after salification, but the yield is not ideal due to side reaction during salification, so that the prevention cost is reduced to some extent, but the reduction is not large. The patent literature also reports a method for forming a complex of diniconazole and inorganic acid salts of alkali metals and alkaline earth metals, wherein the bactericidal and bacteriostatic activities of the complex are higher than those of the diniconazole which is the original parent compound, but the complex yield is not ideal because side reactions still exist in the complex process, so that the control cost is reduced compared with the former two, but still is higher, and the complex process is complex and long.
Disclosure of Invention
(one) solving the technical problems
Aiming at the defects of the prior art, the invention provides a preparation method of a synergistic diniconazole mixed composition, which solves the problems of high manufacturing cost and poor drug effect.
(II) technical scheme
In order to achieve the above purpose, the invention is realized by the following technical scheme: the preparation method of the synergistic diniconazole mixed composition comprises the following components in parts by weight: 10-40 parts of diniconazole, 20-30 parts of magnesium chloride, 20-30 parts of aluminum magnesium silicate, 1-4 parts of sulfur and 1-2 parts of auxiliary agent;
the auxiliary agent comprises a stabilizer, a synergist, a thickener and a defoamer.
Preferably, the auxiliary agent comprises the following components in parts by weight: 1-2 parts of stabilizer, 1-2 parts of synergist, 2-5 parts of thickener and 2-5 parts of defoamer, wherein the stabilizer is any one or two of phosphoric acid and monopotassium phosphate, the synergist is any one or two of organic silicon and vitamin E, the thickener is LD-2002, and the defoamer is GSK-702.
The preparation method of the synergistic diniconazole mixed composition comprises the following steps:
s1: mixing the diniconazole, the magnesium chloride and the aluminum magnesium silicate with water in parts by weight, uniformly stirring, adding an auxiliary agent, processing to obtain emulsifiable concentrate, and filtering to obtain a solution;
s2: adding sulfur into the solution prepared in the step S1, and uniformly stirring again;
s3: and (3) filtering the solution obtained in the step (S2) to obtain the composition solution.
Preferably, the processing temperature is controlled between 30 and 50 ℃, and the stirring speed is 1000 revolutions per minute.
(III) beneficial effects
The invention provides a preparation method of a synergistic diniconazole mixed composition. The beneficial effects are as follows:
1. by adding magnesium chloride and aluminum magnesium silicate into diniconazole raw material, a certain synergistic effect is achieved, organic elements in soil can be improved, and a certain micro-fertilizer effect is achieved while sterilization is achieved, so that plant growth is facilitated.
2. By adding sulfur, the sulfur has synergistic effect on the composition formed by diniconazole, improves the sterilization rate, has a certain deinsectization effect and is beneficial to the growth of plants.
3. The whole preparation is simple, the prevention and control cost can be greatly reduced, and the obtained diniconazole mixed composition has high drug effect and low toxicity.
Detailed Description
The technical solutions of the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention, and it is apparent that the described embodiments are only some embodiments of the present invention, not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Embodiment one:
the embodiment of the invention provides a synergistic diniconazole mixture composition which comprises the following components in parts by weight: 10 parts of diniconazole, 20 parts of magnesium chloride, 20 parts of aluminum magnesium silicate, 1 part of sulfur and 1 part of auxiliary agent, wherein the auxiliary agent comprises a stabilizer, a synergist, a thickener and a defoamer, and the auxiliary agent comprises the following components in parts by weight: 1 part of stabilizer, 1 part of synergist, 2 parts of thickener and 2 parts of defoamer, wherein the stabilizer is a mixture of phosphoric acid and monopotassium phosphate, the synergist is a mixture of organic silicon and vitamin E, the thickener is LD-2002, and the defoamer is GSK-702.
The preparation method of the synergistic diniconazole mixed composition comprises the following steps:
s1: mixing the diniconazole, the magnesium chloride and the aluminum magnesium silicate with water in parts by weight, uniformly stirring at the stirring speed of 1000 revolutions per minute, adding an auxiliary agent, processing, controlling the processing temperature at 40 ℃, forming emulsifiable concentrate, and filtering to obtain a solution;
s2: adding sulfur into the solution prepared in the step S1, and uniformly stirring again;
s3: and (3) filtering the solution obtained in the step (S2) to obtain the composition solution.
Embodiment two:
the embodiment of the invention provides a synergistic diniconazole mixture composition which comprises the following components in parts by weight: 20 parts of diniconazole, 20 parts of magnesium chloride, 20 parts of aluminum magnesium silicate, 2 parts of sulfur and 1 part of auxiliary agent, wherein the auxiliary agent comprises a stabilizer, a synergist, a thickener and a defoamer, and the auxiliary agent comprises the following components in parts by weight: 1 part of stabilizer, 1 part of synergist, 3 parts of thickener and 3 parts of defoamer, wherein the stabilizer is a mixture of phosphoric acid and monopotassium phosphate, the synergist is a mixture of organic silicon and vitamin E, the thickener is LD-2002, and the defoamer is GSK-702.
The preparation method of the synergistic diniconazole mixed composition comprises the following steps:
s1: mixing the diniconazole, the magnesium chloride and the aluminum magnesium silicate with water in parts by weight, uniformly stirring at the stirring speed of 1000 revolutions per minute, adding an auxiliary agent, processing, controlling the processing temperature at 40 ℃, forming emulsifiable concentrate, and filtering to obtain a solution;
s2: adding sulfur into the solution prepared in the step S1, and uniformly stirring again;
s3: and (3) filtering the solution obtained in the step (S2) to obtain the composition solution.
Embodiment III:
the embodiment of the invention provides a synergistic diniconazole mixture composition which comprises the following components in parts by weight: 30 parts of diniconazole, 30 parts of magnesium chloride, 30 parts of aluminum magnesium silicate, 3 parts of sulfur and 2 parts of auxiliary agents, wherein the auxiliary agents comprise a stabilizer, a synergist, a thickener and a defoaming agent, and the auxiliary agents comprise the following components in parts by weight: 2 parts of stabilizer, 2 parts of synergist, 4 parts of thickener and 4 parts of defoamer, wherein the stabilizer is a mixture of phosphoric acid and monopotassium phosphate, the synergist is a mixture of organic silicon and vitamin E, the thickener is LD-2002, and the defoamer is GSK-702.
The preparation method of the synergistic diniconazole mixed composition comprises the following steps:
s1: mixing the diniconazole, the magnesium chloride and the aluminum magnesium silicate with water in parts by weight, uniformly stirring at the stirring speed of 1000 revolutions per minute, adding an auxiliary agent, processing, controlling the processing temperature at 40 ℃, forming emulsifiable concentrate, and filtering to obtain a solution;
s2: adding sulfur into the solution prepared in the step S1, and uniformly stirring again;
s3: and (3) filtering the solution obtained in the step (S2) to obtain the composition solution.
Embodiment four:
the embodiment of the invention provides a synergistic diniconazole mixture composition which comprises the following components in parts by weight: 40 parts of diniconazole, 30 parts of magnesium chloride, 30 parts of aluminum magnesium silicate, 4 parts of sulfur and 2 parts of auxiliary agents, wherein the auxiliary agents comprise a stabilizer, a synergist, a thickener and a defoaming agent, and the auxiliary agents comprise the following components in parts by weight: 2 parts of stabilizer, 2 parts of synergist, 5 parts of thickener and 5 parts of defoamer, wherein the stabilizer is a mixture of phosphoric acid and monopotassium phosphate, the synergist is a mixture of organic silicon and vitamin E, the thickener is LD-2002, and the defoamer is GSK-702.
The preparation method of the synergistic diniconazole mixed composition comprises the following steps:
s1: mixing the diniconazole, the magnesium chloride and the aluminum magnesium silicate with water in parts by weight, uniformly stirring at the stirring speed of 1000 revolutions per minute, adding an auxiliary agent, processing, controlling the processing temperature at 40 ℃, forming emulsifiable concentrate, and filtering to obtain a solution;
s2: adding sulfur into the solution prepared in the step S1, and uniformly stirring again;
s3: and (3) filtering the solution obtained in the step (S2) to obtain the composition solution.
Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (4)
1. The synergistic diniconazole mixed composition is characterized by comprising the following components in parts by weight: 10-40 parts of diniconazole, 20-30 parts of magnesium chloride, 20-30 parts of aluminum magnesium silicate, 1-4 parts of sulfur and 1-2 parts of auxiliary agent;
the auxiliary agent comprises a stabilizer, a synergist, a thickener and a defoamer.
2. The synergistic diniconazole combination according to claim 1, wherein: the auxiliary agent comprises the following components in parts by weight: 1-2 parts of stabilizer, 1-2 parts of synergist, 2-5 parts of thickener and 2-5 parts of defoamer, wherein the stabilizer is any one or two of phosphoric acid and monopotassium phosphate, the synergist is any one or two of organic silicon and vitamin E, the thickener is LD-2002, and the defoamer is GSK-702.
3. The method for preparing the synergistic diniconazole mixture composition according to claim 1, comprising the following steps:
s1: mixing the diniconazole, the magnesium chloride and the aluminum magnesium silicate with water in parts by weight, uniformly stirring, adding an auxiliary agent, processing to obtain emulsifiable concentrate, and filtering to obtain a solution;
s2: adding sulfur into the solution prepared in the step S1, and uniformly stirring again;
s3: and (3) filtering the solution obtained in the step (S2) to obtain the composition solution.
4. The method for preparing the synergistic diniconazole mixture composition according to claim 3, wherein: the processing temperature is controlled between 30 and 50 ℃, and the stirring speed is 1000 revolutions per minute.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210585968.XA CN117158433A (en) | 2022-05-26 | 2022-05-26 | Preparation method of synergistic diniconazole mixed composition |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210585968.XA CN117158433A (en) | 2022-05-26 | 2022-05-26 | Preparation method of synergistic diniconazole mixed composition |
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| CN117158433A true CN117158433A (en) | 2023-12-05 |
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| CN202210585968.XA Pending CN117158433A (en) | 2022-05-26 | 2022-05-26 | Preparation method of synergistic diniconazole mixed composition |
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- 2022-05-26 CN CN202210585968.XA patent/CN117158433A/en active Pending
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