CN117104748A - Biological sample storage method and automatic storage equipment thereof - Google Patents
Biological sample storage method and automatic storage equipment thereof Download PDFInfo
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- CN117104748A CN117104748A CN202311171212.1A CN202311171212A CN117104748A CN 117104748 A CN117104748 A CN 117104748A CN 202311171212 A CN202311171212 A CN 202311171212A CN 117104748 A CN117104748 A CN 117104748A
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- 239000012472 biological sample Substances 0.000 title claims abstract description 135
- 238000000034 method Methods 0.000 title claims abstract description 24
- 238000007710 freezing Methods 0.000 claims abstract description 59
- 230000008014 freezing Effects 0.000 claims abstract description 59
- 239000000523 sample Substances 0.000 claims abstract description 10
- 238000005138 cryopreservation Methods 0.000 claims description 17
- 230000001965 increasing effect Effects 0.000 description 4
- 241000274582 Pycnanthus angolensis Species 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000007726 management method Methods 0.000 description 2
- 239000011087 paperboard Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65G—TRANSPORT OR STORAGE DEVICES, e.g. CONVEYORS FOR LOADING OR TIPPING, SHOP CONVEYOR SYSTEMS OR PNEUMATIC TUBE CONVEYORS
- B65G1/00—Storing articles, individually or in orderly arrangement, in warehouses or magazines
- B65G1/02—Storage devices
- B65G1/04—Storage devices mechanical
- B65G1/0485—Check-in, check-out devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65G—TRANSPORT OR STORAGE DEVICES, e.g. CONVEYORS FOR LOADING OR TIPPING, SHOP CONVEYOR SYSTEMS OR PNEUMATIC TUBE CONVEYORS
- B65G1/00—Storing articles, individually or in orderly arrangement, in warehouses or magazines
- B65G1/02—Storage devices
- B65G1/04—Storage devices mechanical
- B65G1/137—Storage devices mechanical with arrangements or automatic control means for selecting which articles are to be removed
- B65G1/1373—Storage devices mechanical with arrangements or automatic control means for selecting which articles are to be removed for fulfilling orders in warehouses
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- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The invention provides a biological sample storage method and an automatic storage device thereof, which can distinguish and store biological samples of front and rear batches, so that the biological samples of the front batch can only be taken out in the form of a freezing box, and then the biological samples of the rear batch can be taken out in the form of the freezing box or independently, and can be rapidly distinguished and establish efficient sample management when transferring the biological samples to the automatic storage device, thereby avoiding confusion of the biological samples.
Description
Technical Field
The invention relates to the field of biological sample storage, in particular to a method and equipment for storing biological samples in different batches.
Background
With the increasing wide use of low-temperature automated storage devices for biological samples, the need to transfer biological samples originally stored in old storage devices (hereinafter referred to as former batch of biological samples) to the automated devices is often met, while most of old storage devices are manual devices, and most of related information records of biological samples are recorded manually by personnel, so that for the biological samples which need to be transferred and stored to the automated devices seamlessly, and for the new biological samples which need to be stored directly to the automated devices later (hereinafter referred to as latter batch of biological samples), the coexistence of samples, information matching and non-inductive compatibility are needed.
After the biological samples of the previous batch are transferred to the new equipment, the biological samples of the previous batch cannot be distinguished from the biological samples of the next batch, and after the biological samples of the previous batch and the biological samples of the next batch are continuously accessed to the equipment for a long time, the condition that the same freezing box exists between the biological samples of the previous batch and the biological samples of the next batch can be caused, so that the management difficulty of the biological samples of the previous batch and the biological samples of the next batch is increased, and the related information matching and updating can be more complicated.
Disclosure of Invention
The invention aims to overcome the defects of the background technology, and establishes a method capable of effectively managing biological samples of different batches, and the different batches can be distinguished by setting the operation type of the samples when the samples are put in storage.
To achieve the above object, the present invention provides a biological sample storage method, comprising:
step one, placing the biological samples in a front batch and a rear batch into different freezing boxes respectively to form the biological sample freezing boxes in the front batch and the biological sample freezing boxes in the rear batch;
step two, generating a warehouse entry order, namely generating a warehouse entry order of a biological sample freezing box of a previous batch, namely generating a warehouse entry order of a biological sample freezing box of a later batch, namely generating a warehouse entry order of a biological sample freezing box of the later batch;
thirdly, storing the biological sample freezing box into low-temperature automatic storage equipment according to the previous batch warehouse entry list and the later batch warehouse entry list;
the method is characterized in that: the front batch of biological samples can only be taken out of the warehouse along with the front batch of biological sample cryopreservation boxes, and the rear batch of biological samples can be taken out of the warehouse along with the rear batch of biological sample cryopreservation boxes.
Further, the inventory includes the data type of the operation type.
Further, when a warehouse entry is generated in the second step, the operation types of the previous batch warehouse entry and the subsequent batch warehouse entry are assigned different values.
Further, the operation type value of the preceding lot entry is 1, and the operation type value of the following lot entry is 2.
Further, the warehouse entry order also includes biological sample data and cryopreservation box data.
Further, the three kinds of low-temperature automatic storage equipment in the step identify whether the biological samples are the previous batch of biological samples or the later batch of biological samples according to the numerical value of the operation type of the warehouse entry.
And step four, the method further comprises the step of displaying the ex-warehouse information, wherein when the biological samples are the biological samples of the previous batch, the display interface of the automatic storage device does not display the biological sample data list, and only displays the freezing box data list, so that the biological samples of the previous batch can only be ex-warehouse in the form of the freezing box and cannot be ex-warehouse alone.
Further, in the fourth step, when the biological sample is a later batch of biological samples, the display interface of the automated storage device displays both the biological sample data list and the cryopreservation box data list, so that the later batch of biological samples can be delivered in the form of the cryopreservation box or can be delivered separately.
Further, the display interfaces of the automated storage equipment are divided into a sample display interface and a freezing box display interface.
And step five, after the frozen storage boxes of the biological samples in the previous batch are delivered out of the warehouse, when the frozen storage boxes are required to be stored in the automatic equipment again, the warehouse entry list adds and deletes the biological sample data according to the information of the frozen storage boxes when the frozen storage boxes are delivered out of the warehouse, so that the warehouse entry list is quickly generated.
An automated storage unit employing the aforementioned biological specimen storage method.
Further, the automated storage device comprises a control system, an operation region, and a sample storage region; the control system is used for displaying the storage condition of the biological sample and performing warehouse-in control; the handling area is used for grabbing a cryopreserved box or a biological sample test tube.
Further, the sample storage region is a cryogenic storage tank, and the handling region includes a gripping mechanism and a lifting mechanism for lifting the cryopreservation cassette from the cryogenic storage tank to the handling region.
The method has the beneficial effects that by distinguishing the biological samples of the front batch and the rear batch and only allowing the biological samples of the front time to go out of the warehouse in the form of the freezing box, the biological samples of the front batch and the rear batch can be completely isolated and distinguished, the warehouse-in efficiency is greatly improved, the confusion of biological sample information is avoided, and the management effect is improved.
Drawings
In order to more clearly illustrate the embodiments of the invention or the technical solutions in the prior art, the drawings that are required in the embodiments or the description of the prior art will be briefly described, it being obvious that the drawings in the following description are only some embodiments of the invention, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 is a schematic diagram of a biological sample storage method of the present invention;
FIG. 2 is a flow chart of a method of storing a biological sample according to the present invention;
FIG. 3 is a perspective view of a cryogenic automated storage facility;
fig. 4 is a perspective cross-section of a cryogenic automation storage device.
Detailed Description
The invention is described in further detail below with reference to the accompanying drawings and specific examples.
Referring to fig. 1 and 2, the biological samples of the present invention are stored in the low-temperature automated storage device after being placed in the cryopreservation cassette, and the biological samples to be transferred to the low-temperature automated storage device are collectively referred to as a previous batch of biological samples, which are stored in the old storage device, are first collectively placed in the cryopreservation cassette, which is referred to as a previous batch of biological sample cryopreservation cassette; the new biological samples which are directly stored in the low-temperature automatic storage equipment are collectively called as a later-batch biological sample, and are uniformly placed in a freezing box, and the freezing box is called as a later-batch biological sample freezing box.
And then, generating a warehouse entry list according to the related information of the biological sample freezing box of the previous batch and the biological sample freezing box of the later batch, wherein the warehouse entry list at least comprises three data information of operation types, biological sample data and freezing box data, and the operation types of the biological sample freezing boxes of the previous batch and the biological sample freezing boxes of the later batch are different.
And secondly, storing the front and back batches of biological sample cryopreservation boxes into low-temperature automatic storage equipment, wherein the low-temperature automatic storage equipment can judge whether the cryopreservation boxes are the front batch of biological sample cryopreservation boxes or the back batch of biological sample cryopreservation boxes according to operation type data information in a warehouse entry order.
Finally, if the biological sample freezing box of the previous batch is judged, the biological sample data of the biological sample of the previous batch is not displayed on the low-temperature automatic storage equipment, and only the freezing box data of the biological sample of the previous batch can be displayed, so that the biological sample freezing box can only be operated in the form of the freezing box for delivery, and can not be independently delivered; if the judgment is that the biological sample freezing box of the later batch is adopted, the low-temperature automatic storage equipment can display the biological sample data of the biological sample of the later batch and also can display the freezing box data of the biological sample of the later batch, so that the biological sample freezing box can be taken out of the warehouse in the form of the freezing box or taken out of the warehouse independently.
After the current batch of biological sample freezing box is taken out of the warehouse, the biological samples of the previous batch are added or part of the biological samples of the previous batch are removed from the freezing box, so that the corresponding biological sample data are subjected to increasing and decreasing changes, and when the freezing box is put in warehouse again, a new warehouse entry bill is not required to be generated, and the biological sample data are only increased and decreased on the original warehouse entry bill, so that the effect of quick warehouse entry is achieved.
Specifically, when a warehouse entry list is created, the variable name of the operation type in the warehouse entry list is defined as an operation type, the warehouse entry list of the biological sample freezing box of the previous batch is set as a specific value X which is agreed with the operation type in the warehouse entry list of the biological sample freezing box of the previous batch, the program of the low-temperature automatic storage equipment adds the value Y of the variable Board type representing the type of the freezing box to X, assigns the value Y to the variable Board type representing the type of the freezing box, then writes a database, wherein the front biological sample freezing box board type of the previous batch in the database is X+Y, and the status flag bit of the biological sample of the previous batch is OLDIN. Then, when a sample list is created on a sample-out-warehouse selection interface, filtering out biological samples with the status flag bit of OLDIN; when the interface of the freezing box is selected for establishing a freezing box list, the freezing box with the type of X+Y is displayed, and the whole freezing box can be taken out of the warehouse after the freezing box is checked.
For the biological samples of the later batch, a warehouse entry list of the freezing storage box is also required to be created, when a warehouse entry list database is created, a normal numerical value is written IN a column of an operation type, the freezing storage box board type=Y of the biological samples of the later batch IN the database, and the state flag bit of the biological samples of the later batch is IN; the related items of the biological samples of the subsequent batch can be displayed and checked on the list interface for selecting the biological samples and the list interface for selecting the freezing box, so that a plurality of products and the whole freezing box are supported to be discharged during the discharging.
As shown in fig. 3 and 4, a low-temperature automated storage apparatus, which includes the automated storage apparatus including a control system 1, an operation region 2, and a sample storage region 3, is capable of applying the storage methods shown in fig. 1 and 2; the control system is used for displaying the storage condition of the biological sample and performing warehouse-in control; the handling area is used for grabbing a cryopreserved box or a biological sample test tube. The sample storage area is a cryogenic storage tank 4, and the operating area includes a lifting mechanism 5 for lifting the freezing box from the cryogenic storage tank to the operating area and a gripping mechanism 6.
The above embodiments are preferred embodiments of the present invention, and besides, the present invention may be implemented in other ways, and any obvious substitution is within the scope of the present invention without departing from the concept of the present invention.
Claims (12)
1. A method of storing a biological sample, comprising:
step one, placing the biological samples in a front batch and a rear batch into different freezing boxes respectively to form the biological sample freezing boxes in the front batch and the biological sample freezing boxes in the rear batch;
step two, generating a warehouse entry order, namely generating a warehouse entry order of a biological sample freezing box of a previous batch, namely generating a warehouse entry order of a biological sample freezing box of a later batch, namely generating a warehouse entry order of a biological sample freezing box of the later batch;
thirdly, storing the biological sample freezing box into low-temperature automatic storage equipment according to the previous batch warehouse entry list and the later batch warehouse entry list;
the method is characterized in that: the front batch of biological samples can only be taken out of the warehouse along with the front batch of biological sample cryopreservation boxes, and the rear batch of biological samples can be taken out of the warehouse along with the rear batch of biological sample cryopreservation boxes.
2. A method of storing biological samples according to claim 1, characterized in that the entry list comprises a data type of operation type.
3. A biological sample storage method according to claim 2, wherein the operation types of the preceding lot entry and the following lot entry are assigned different values when the entry is generated in step two.
4. A method of storing biological samples according to claim 3, wherein the order further comprises biological sample data and cryopreservation cassette data.
5. The method according to claim 4, wherein the three kinds of the cryogenic automated storage apparatuses recognize whether the biological samples are the previous batch of biological samples or the subsequent batch of biological samples according to the numerical value of the operation type of the warehouse entry order.
6. The method according to claim 5, further comprising a step four of displaying, when the biological sample is a previous batch of biological samples, the display interface of the automated storage apparatus will not display the biological sample data list thereof, and only display the cryopreserved box data list thereof, so that the previous batch of biological samples can only be stored in the form of a cryopreserved box and cannot be separately stored.
7. The method according to claim 6, wherein in the fourth step, when the biological sample is a later batch of biological samples, the display interface of the automated storage equipment displays both the biological sample data list and the freezing box data list, so that the later batch of biological samples can be taken out in the form of freezing boxes or taken out separately.
8. The method of claim 7, wherein the display interface of the automated storage facility is divided into a sample display interface and a freezing box display interface.
9. The method for storing biological samples according to claim 8, further comprising the step of adding and deleting biological sample data according to information when the frozen boxes of the biological samples of the previous batch are out of the warehouse and need to be stored in the automation equipment again, so that the warehouse entry list can be quickly generated.
10. An automated storage unit applying the biological specimen storage method of the preceding claims 1-9.
11. An automated storage unit according to claim 10, characterized in that the automated storage unit comprises a control system (1), an operating zone (2) and a sample storage zone (3); the control system (1) is used for displaying the storage condition of the biological sample and performing warehousing control; the handling area (2) is used for grabbing a freezing box or a biological sample test tube.
12. An automated storage unit according to claim 11, wherein the sample storage area (3) is a cryogenic storage tank (4), and wherein the handling area (2) comprises a gripping mechanism (5) and a lifting mechanism (6), and wherein the lifting mechanism (6) is adapted to lift the cryopreservation cassette from the cryogenic storage tank (4) to the handling area (2).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311171212.1A CN117104748A (en) | 2023-09-11 | 2023-09-11 | Biological sample storage method and automatic storage equipment thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311171212.1A CN117104748A (en) | 2023-09-11 | 2023-09-11 | Biological sample storage method and automatic storage equipment thereof |
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| CN117104748A true CN117104748A (en) | 2023-11-24 |
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| CN202311171212.1A Pending CN117104748A (en) | 2023-09-11 | 2023-09-11 | Biological sample storage method and automatic storage equipment thereof |
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2023
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