CN117062828A - 在环或末端处与肽标签相互作用的多肽及其用途 - Google Patents

在环或末端处与肽标签相互作用的多肽及其用途 Download PDF

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Publication number
CN117062828A
CN117062828A CN202280024145.8A CN202280024145A CN117062828A CN 117062828 A CN117062828 A CN 117062828A CN 202280024145 A CN202280024145 A CN 202280024145A CN 117062828 A CN117062828 A CN 117062828A
Authority
CN
China
Prior art keywords
seq
polypeptide
amino acid
peptide
acid sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202280024145.8A
Other languages
English (en)
Chinese (zh)
Inventor
马克·豪沃思
维卡什·亚达夫
马泰奥·费拉
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oxford University Innovation Ltd
Original Assignee
Oxford University Innovation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oxford University Innovation Ltd filed Critical Oxford University Innovation Ltd
Publication of CN117062828A publication Critical patent/CN117062828A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/90—Fusion polypeptide containing a motif for post-translational modification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN202280024145.8A 2021-04-08 2022-04-01 在环或末端处与肽标签相互作用的多肽及其用途 Pending CN117062828A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB2104999.4A GB202104999D0 (en) 2021-04-08 2021-04-08 Polypeptides that interact with peptide tags at loops or termini and uses thereof
GB2104999.4 2021-04-08
PCT/GB2022/050841 WO2022214795A1 (en) 2021-04-08 2022-04-01 Polypeptides that interact with peptide tags at loops or termini and uses thereof

Publications (1)

Publication Number Publication Date
CN117062828A true CN117062828A (zh) 2023-11-14

Family

ID=75949566

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202280024145.8A Pending CN117062828A (zh) 2021-04-08 2022-04-01 在环或末端处与肽标签相互作用的多肽及其用途

Country Status (10)

Country Link
US (1) US20240182530A1 (https=)
EP (1) EP4320140A1 (https=)
JP (1) JP2024513126A (https=)
KR (1) KR20230165919A (https=)
CN (1) CN117062828A (https=)
AU (1) AU2022254857A1 (https=)
BR (1) BR112023020647A2 (https=)
CA (1) CA3214614A1 (https=)
GB (1) GB202104999D0 (https=)
WO (1) WO2022214795A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB202313175D0 (en) 2023-08-30 2023-10-11 Univ Oxford Innovation Ltd A bivalent polypeptide scaffold and uses thereof
GB202315107D0 (en) 2023-10-02 2023-11-15 Univ Oxford Innovation Ltd Polypeptides and peptide tags capable of spontaneous isopeptide bond formation at low temperature and low pH and uses thereof
GB202317925D0 (en) 2023-11-23 2024-01-10 Spybiotech Ltd Vaccines

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU530410B2 (en) 1978-02-21 1983-07-14 Sintef Preparing aqueous emulsions
GB201002362D0 (en) 2010-02-11 2010-03-31 Isis Innovation Peptide tag systems that spontaneously form an irreversible link to protein partners via isopeptide bonds
GB201509782D0 (en) * 2015-06-05 2015-07-22 Isis Innovation Methods and products for fusion protein synthesis
GB201705750D0 (en) 2017-04-10 2017-05-24 Univ Oxford Innovation Ltd Peptide ligase and use therof
GB201706430D0 (en) 2017-04-24 2017-06-07 Univ Oxford Innovation Ltd Proteins and peptide tags with enhanced rate of spontaneous isopeptide bond formation and uses thereof
GB201819850D0 (en) 2018-12-05 2019-01-23 Univ Oxford Innovation Ltd Polypeptide and its use in affinity purification
GB201903479D0 (en) 2019-03-14 2019-05-01 Univ Oxford Innovation Ltd Polypeptide with enchanced rate of spontaneous isopeptide bond formation with it's peptide tag partner and uses thereof

Also Published As

Publication number Publication date
JP2024513126A (ja) 2024-03-21
AU2022254857A1 (en) 2023-11-23
WO2022214795A1 (en) 2022-10-13
KR20230165919A (ko) 2023-12-05
US20240182530A1 (en) 2024-06-06
CA3214614A1 (en) 2022-10-13
BR112023020647A2 (pt) 2023-12-05
EP4320140A1 (en) 2024-02-14
GB202104999D0 (en) 2021-05-26

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