CN116925234B - 一种编码抗vegf-a和ang-2双特异性抗体的aav载体 - Google Patents
一种编码抗vegf-a和ang-2双特异性抗体的aav载体 Download PDFInfo
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Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210356939.6A CN116925234B (zh) | 2022-04-02 | 2022-04-02 | 一种编码抗vegf-a和ang-2双特异性抗体的aav载体 |
| EP23778495.4A EP4506367A4 (en) | 2022-04-02 | 2023-03-31 | VAA VECTOR ENCODING A BISPECIFIC ANTI-VEGF-A AND ANG-2 ANTIBODY |
| PCT/CN2023/085610 WO2023186131A1 (zh) | 2022-04-02 | 2023-03-31 | 一种编码抗vegf-a和ang-2双特异性抗体的aav载体 |
| CN202380017956.XA CN118574856A (zh) | 2022-04-02 | 2023-03-31 | 一种编码抗vegf-a和ang-2双特异性抗体的aav载体 |
| US18/853,409 US20250223345A1 (en) | 2022-04-02 | 2023-03-31 | Aav vector encoding anti-vegf-a and ang-2 bispecific antibody |
| JP2025503026A JP2025512121A (ja) | 2022-04-02 | 2023-03-31 | 抗VEGF-Aおよび抗Ang-2二重特異性抗体をコードするAAVベクター |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210356939.6A CN116925234B (zh) | 2022-04-02 | 2022-04-02 | 一种编码抗vegf-a和ang-2双特异性抗体的aav载体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN116925234A CN116925234A (zh) | 2023-10-24 |
| CN116925234B true CN116925234B (zh) | 2024-05-31 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210356939.6A Active CN116925234B (zh) | 2022-04-02 | 2022-04-02 | 一种编码抗vegf-a和ang-2双特异性抗体的aav载体 |
| CN202380017956.XA Pending CN118574856A (zh) | 2022-04-02 | 2023-03-31 | 一种编码抗vegf-a和ang-2双特异性抗体的aav载体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202380017956.XA Pending CN118574856A (zh) | 2022-04-02 | 2023-03-31 | 一种编码抗vegf-a和ang-2双特异性抗体的aav载体 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20250223345A1 (https=) |
| EP (1) | EP4506367A4 (https=) |
| JP (1) | JP2025512121A (https=) |
| CN (2) | CN116925234B (https=) |
| WO (1) | WO2023186131A1 (https=) |
Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5877291A (en) * | 1992-12-11 | 1999-03-02 | The Dow Chemical Company | Multivalent single chain antibodies |
| CN101370519A (zh) * | 2005-12-15 | 2009-02-18 | 阿斯利康(瑞典)有限公司 | 治疗癌症的促血管生成素-2拮抗剂和VEGF-A、KDR和/或FIt1的拮抗剂的组合 |
| CN103936860A (zh) * | 2008-10-08 | 2014-07-23 | 霍夫曼-拉罗奇有限公司 | 双特异性抗-vegf/抗-ang-2抗体 |
| CN104761643A (zh) * | 2003-08-01 | 2015-07-08 | 健泰科生物技术公司 | 抗-vegf抗体 |
| CN105085678A (zh) * | 2004-12-21 | 2015-11-25 | 阿斯利康公司 | 血管生成素-2的抗体及其应用 |
| CN107074941A (zh) * | 2014-11-10 | 2017-08-18 | 豪夫迈·罗氏有限公司 | 双特异性抗体和用于眼科学的方法 |
| CN109863171A (zh) * | 2016-08-23 | 2019-06-07 | 免疫医疗有限公司 | 抗vegf-a和抗ang2抗体及其用途 |
| CN111727201A (zh) * | 2017-10-18 | 2020-09-29 | 再生生物股份有限公司 | 完全人源翻译后修饰的抗体治疗剂 |
| CN113185613A (zh) * | 2021-04-13 | 2021-07-30 | 武汉大学 | 新型冠状病毒s蛋白及其亚单位疫苗 |
| WO2021255590A1 (en) * | 2020-06-16 | 2021-12-23 | Intas Pharmaceuticals Ltd. | An anti-vegf scfv adeno-associated virus (aav) vector and uses thereof |
| WO2021255589A1 (en) * | 2020-06-16 | 2021-12-23 | Intas Pharmaceuticals Ltd. | An anti-vegf scfab adeno-associated virus (aav) vector and uses thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008501621A (ja) * | 2003-05-31 | 2008-01-24 | マイクロメット アクツィエン ゲゼルシャフト | B細胞関連疾患を処置するための二重特異性抗cd3、抗cd19抗体構築物を含む薬学的組成物 |
| SG11201408538PA (en) * | 2012-07-13 | 2015-02-27 | Roche Glycart Ag | Bispecific anti-vegf/anti-ang-2 antibodies and their use in the treatment of ocular vascular diseases |
| KR20150063847A (ko) * | 2013-12-02 | 2015-06-10 | 삼성전자주식회사 | 항 VEGF-A/항 Ang2 이중 특이 항체 |
| JP2017534644A (ja) * | 2014-11-10 | 2017-11-24 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 抗ang2抗体及び使用方法 |
| WO2018007314A1 (en) * | 2016-07-04 | 2018-01-11 | F. Hoffmann-La Roche Ag | Novel antibody format |
| EP3687464A4 (en) * | 2017-09-27 | 2021-09-29 | REGENXBIO Inc. | TREATMENT OF EYE DISEASES WITH A TOTALLY HUMAN POST-TRANSLATION MODIFIED ANTI-VEGF FAB |
| EP4208201A1 (en) * | 2020-09-04 | 2023-07-12 | F. Hoffmann-La Roche AG | Antibody that binds to vegf-a and ang2 and methods of use |
| TW202227509A (zh) * | 2020-09-15 | 2022-07-16 | 日商參天製藥股份有限公司 | 針對vegf及ang2之雙特異性結合分子 |
| CN115772544B (zh) * | 2021-09-06 | 2024-04-26 | 合肥星眸生物科技有限公司 | 抗vegf-a和ang-2的aav载体 |
-
2022
- 2022-04-02 CN CN202210356939.6A patent/CN116925234B/zh active Active
-
2023
- 2023-03-31 CN CN202380017956.XA patent/CN118574856A/zh active Pending
- 2023-03-31 JP JP2025503026A patent/JP2025512121A/ja active Pending
- 2023-03-31 WO PCT/CN2023/085610 patent/WO2023186131A1/zh not_active Ceased
- 2023-03-31 US US18/853,409 patent/US20250223345A1/en active Pending
- 2023-03-31 EP EP23778495.4A patent/EP4506367A4/en active Pending
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5877291A (en) * | 1992-12-11 | 1999-03-02 | The Dow Chemical Company | Multivalent single chain antibodies |
| CN104761643A (zh) * | 2003-08-01 | 2015-07-08 | 健泰科生物技术公司 | 抗-vegf抗体 |
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| CN111727201A (zh) * | 2017-10-18 | 2020-09-29 | 再生生物股份有限公司 | 完全人源翻译后修饰的抗体治疗剂 |
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| CN118574856A (zh) | 2024-08-30 |
| EP4506367A4 (en) | 2025-09-24 |
| EP4506367A1 (en) | 2025-02-12 |
| JP2025512121A (ja) | 2025-04-16 |
| US20250223345A1 (en) | 2025-07-10 |
| CN116925234A (zh) | 2023-10-24 |
| WO2023186131A1 (zh) | 2023-10-05 |
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